Detailed information for compound 1437840

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 389.833 | Formula: C19H20ClN3O4
  • H donors: 2 H acceptors: 4 LogP: 2.09 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CC(c1ccccc1)NC(=O)C)OC(C(=O)Nc1ccc(cn1)Cl)C
  • InChi: 1S/C19H20ClN3O4/c1-12(19(26)23-17-9-8-15(20)11-21-17)27-18(25)10-16(22-13(2)24)14-6-4-3-5-7-14/h3-9,11-12,16H,10H2,1-2H3,(H,22,24)(H,21,23,26)
  • InChiKey: CGDRYAJGVJVNBF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0368 0.0295 0.0295
Echinococcus multilocularis dual specificity 0.0223 0.0113 0.0186
Brugia malayi Protein kinase domain containing protein 0.0863 0.0917 0.0909
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0176 0.0054 0.0544
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0782 0.0815 0.0815
Onchocerca volvulus 0.0351 0.0274 0.0698
Trichomonas vaginalis CAMK family protein kinase 0.0352 0.0275 0.2908
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0169 0.0045 0.0442
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.1349 0.1529 0.4749
Loa Loa (eye worm) hypothetical protein 0.0821 0.0864 0.0864
Echinococcus granulosus dual specificity 0.0223 0.0113 0.0306
Giardia lamblia Kinase, CMGC CDK 0.0871 0.0928 0.9891
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0327 0.0244 0.2597
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0248 0.0144 0.0245
Trichomonas vaginalis STE family protein kinase 0.0215 0.0103 0.1059
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0032 0.0308
Brugia malayi Protein kinase domain containing protein 0.0276 0.018 0.0171
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0765 0.0794 0.8552
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0347 0.0269 0.2867
Loa Loa (eye worm) TK/FAK protein kinase 0.065 0.065 0.065
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0168 0.0044 0.0434
Echinococcus granulosus Protein kinase C brain isozyme 0.0477 0.0432 0.1307
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0274 0.0176 0.0539
Loa Loa (eye worm) TK/FER protein kinase 0.0344 0.0265 0.0265
Echinococcus multilocularis 0.0207 0.0092 0.0147
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0352 0.0275 0.0275
Echinococcus multilocularis mitogen activated protein kinase 0.0169 0.0045 0.0056
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0421 0.0362 0.0661
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0344 0.0265 0.0476
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Loa Loa (eye worm) TK protein kinase 0.0577 0.0558 0.0558
Echinococcus multilocularis death associated protein kinase 1 0.4317 0.5261 1
Loa Loa (eye worm) hypothetical protein 0.0352 0.0275 0.0275
Brugia malayi Protein kinase domain containing protein 0.0348 0.027 0.0261
Echinococcus multilocularis 0.0744 0.0768 0.1434
Echinococcus granulosus tyrosine protein kinase Fyn 0.0421 0.0362 0.1088
Schistosoma mansoni tyrosine kinase 0.0274 0.0176 0.0539
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0821 0.0864 0.9311
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.036 0.0285 0.0285
Brugia malayi protein kinase C3,putative 0.0289 0.0196 0.0187
Giardia lamblia Kinase, CMGC GSK 0.0862 0.0917 0.9772
Brugia malayi SH2 domain containing protein 0.0216 0.0104 0.0096
Schistosoma mansoni nck2/grb4 0.0158 0.0031 0.0085
Brugia malayi Protein kinase domain containing protein 0.0168 0.0044 0.0035
Trichomonas vaginalis AGC family protein kinase 0.022 0.0109 0.1132
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0506 0.0469 0.5035
Entamoeba histolytica protein kinase , putative 0.0347 0.0269 0.1024
Schistosoma mansoni serine/threonine protein kinase 0.0269 0.017 0.0521
Echinococcus granulosus homeodomain interacting protein kinase 3 0.2219 0.2623 0.8184
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0222 0.0111 0.1159
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Schistosoma mansoni serine/threonine protein kinase 0.0863 0.0917 0.2856
Giardia lamblia Kinase, CAMK CAMKL 0.0279 0.0183 0.192
Trichomonas vaginalis CAMK family protein kinase 0.0222 0.0111 0.1147
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0189 0.007 0.0208
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0506 0.0469 0.5035
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.036 0.0285 0.0285
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0168 0.0044 0.0434
Loa Loa (eye worm) hypothetical protein 0.0158 0.0031 0.0031
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0222 0.0111 0.1159
Trichomonas vaginalis CAMK family protein kinase 0.0222 0.0111 0.1147
Schistosoma mansoni tyrosine kinase 0.0589 0.0574 0.1782
Brugia malayi Immunoglobulin I-set domain containing protein 0.0192 0.0074 0.0065
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.2219 0.2623 0.2623
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0821 0.0864 0.9311
Trypanosoma cruzi NIMA-related kinase, putative 0.0139 0.0007 0.0038
Trichomonas vaginalis STE family protein kinase 0.0236 0.0129 0.1346
Trypanosoma brucei Mitogen-activated protein kinase 10, putative 0.0176 0.0054 0.0544
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0613 0.0604 0.0604
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0871 0.0928 0.0928
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0421 0.0362 0.0661
Echinococcus granulosus insulin receptor 0.0784 0.0818 0.252
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0156 0.0029 0.0025
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0871 0.0928 0.0928
Plasmodium falciparum casein kinase 2, alpha subunit 0.0185 0.0065 0.0662
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0032 0.0308
Trichomonas vaginalis CAMK family protein kinase 0.0222 0.0111 0.1147
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0139 0.0007 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.0359 0.0283 0.0875
Entamoeba histolytica p21-activated kinase 0.0257 0.0155 0.059
Schistosoma mansoni protein kinase 0.0269 0.017 0.052
Echinococcus granulosus cyclin dependent kinase 7 0.0678 0.0684 0.21
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0139 0.0007 0.0038
Trypanosoma brucei aurora B kinase 0.0347 0.0269 0.2867
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0506 0.0469 0.0469
Echinococcus multilocularis N chimaerin 0.0189 0.007 0.0105
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0236 0.0129 0.0217
Loa Loa (eye worm) TK/ROR protein kinase 0.0175 0.0052 0.0052
Plasmodium vivax serine/threonine protein kinase, putative 0.0168 0.0044 0.0434
Schistosoma mansoni tyrosine kinase 0.0644 0.0642 0.1995
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0167 0.0042 0.005
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0223 0.0113 0.1182
Plasmodium falciparum glycogen synthase kinase 3 0.0862 0.0917 0.988
Onchocerca volvulus 0.2561 0.3052 0.9525
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0765 0.0794 0.0794
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0327 0.0244 0.0244
Schistosoma mansoni serine/threonine protein kinase 0.0222 0.0111 0.0335
Leishmania major protein kinase, putative 0.0863 0.0917 0.9883
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0542 0.0513 0.1563
Entamoeba histolytica protein kinase, putative 0.0328 0.0245 0.0935
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0036
Echinococcus multilocularis serine:threonine protein kinase N2 0.1015 0.1109 0.2085
Toxoplasma gondii AGC kinase 0.047 0.0423 0.4535
Echinococcus granulosus protein kinase shaggy 0.0862 0.0917 0.2829
Entamoeba histolytica protein kinase, putative 0.0139 0.0007 0.0027
Plasmodium falciparum calcium-dependent protein kinase 1 0.0327 0.0244 0.2597
Loa Loa (eye worm) AGC/PKA protein kinase 0.0821 0.0864 0.0864
Leishmania major protein kinase A catalytic subunit isoform 2 0.0821 0.0864 0.9311
Echinococcus granulosus Vam6:Vps39 protein 0.0508 0.0471 0.1431
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0254 0.0151 0.0259
Toxoplasma gondii AGC kinase 0.0821 0.0864 0.9311
Entamoeba histolytica protein kinase, putative 0.0236 0.0129 0.0493
Echinococcus granulosus casein kinase I delta 0.0351 0.0274 0.081
Trichomonas vaginalis AGC family protein kinase 0.0347 0.0269 0.2836
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0242 0.0136 0.0378
Echinococcus granulosus calcium dependent protein kinase 0.0208 0.0094 0.0247
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0518 0.0483 0.0475
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0508 0.0471 0.1431
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0139 0.0007 0.0038
Echinococcus granulosus raf serine:threonine protein kinase 0.0204 0.0089 0.023
Echinococcus multilocularis Immunoglobulin 0.0256 0.0154 0.0265
Brugia malayi hypothetical protein 0.07 0.0713 0.0705
Brugia malayi protein kinase C II. 0.0438 0.0383 0.0375
Brugia malayi serine/threonine-protein kinase PAK 7 0.1079 0.1189 0.1181
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0474 0.0429 0.1297
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0399 0.0334 0.0607
Echinococcus granulosus tyrosine protein kinase HCK 0.0263 0.0163 0.0464
Entamoeba histolytica protein kinase domain containing protein 0.0185 0.0065 0.0247
Echinococcus multilocularis expressed conserved protein 0.0219 0.0108 0.0176
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0036
Brugia malayi Protein kinase domain containing protein 0.0677 0.0684 0.0676
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0477 0.0432 0.0794
Schistosoma mansoni tyrosine kinase 0.0762 0.0791 0.2462
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Plasmodium falciparum calcium-dependent protein kinase 4 0.0327 0.0244 0.2597
Entamoeba histolytica protein kinase, putative 0.0223 0.0113 0.043
Schistosoma mansoni nephrin 0.0329 0.0246 0.0758
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0508 0.0471 0.5062
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0327 0.0244 0.0435
Loa Loa (eye worm) hypothetical protein 0.0454 0.0403 0.0403
Onchocerca volvulus 0.268 0.3202 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0241 0.0135 0.0374
Trichomonas vaginalis CMGC family protein kinase 0.0862 0.0917 0.9772
Schistosoma mansoni hypothetical protein 0.0508 0.0471 0.1463
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0702 0.0715 0.1333
Schistosoma mansoni protein kinase 0.0234 0.0127 0.0385
Echinococcus granulosus protein kinase c epsilon type 0.0438 0.0383 0.1153
Entamoeba histolytica protein kinase domain containing protein 0.0347 0.0269 0.1024
Trichomonas vaginalis CMGC family protein kinase 0.0185 0.0065 0.0654
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0603 0.0591 0.0591
Echinococcus multilocularis cyclin dependent kinase 9 0.0504 0.0466 0.0859
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.0029 0.0078
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0347 0.0269 0.0483
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0347 0.0269 0.1024
Loa Loa (eye worm) hypothetical protein 0.0484 0.0441 0.0441
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0139 0.0007 0.0038
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0518 0.0483 0.1468
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0166 0.0041 0.0406
Trypanosoma brucei polo-like protein kinase 0.0352 0.0275 0.294
Giardia lamblia Kinase, CMGC MAPK 0.0169 0.0045 0.0437
Loa Loa (eye worm) hypothetical protein 0.0395 0.033 0.033
Brugia malayi Immunoglobulin I-set domain containing protein 0.0148 0.0018 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0327 0.0244 0.2569
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Entamoeba histolytica casein kinase, putative 0.0185 0.0065 0.0247
Schistosoma mansoni serine/threonine protein kinase 0.0829 0.0875 0.2725
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0223 0.0113 0.0104
Loa Loa (eye worm) AGC/PKA protein kinase 0.0821 0.0864 0.0864
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0036
Brugia malayi Protein kinase domain containing protein 0.0284 0.0189 0.0181
Leishmania major protein kinase, putative 0.0334 0.0252 0.2691
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0139 0.0007 0.0038
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0032 0.0308
Echinococcus granulosus fibroblast growth factor receptor 4 0.0517 0.0483 0.1467
Schistosoma mansoni serine/threonine-protein kinase 0.0261 0.016 0.049
Echinococcus granulosus serine threonine protein kinase nrc 0.0241 0.0135 0.0374
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Trypanosoma cruzi Protein kinase B 0.0261 0.016 0.1694
Echinococcus granulosus defective proboscis extension response 0.0256 0.0154 0.0436
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.0176 0.0054 0.0054
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.014 0.0009 0.0053
Echinococcus multilocularis casein kinase i 0.0351 0.0274 0.0492
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0168 0.0044 0.0434
Brugia malayi Protein kinase domain containing protein 0.0665 0.0668 0.066
Entamoeba histolytica protein kinase, putative 0.0347 0.0269 0.1024
Schistosoma mansoni vam6/vps39 related 0.0508 0.0471 0.1463
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0613 0.0604 0.1121
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0351 0.0274 0.0274
Brugia malayi Cam kinase protein 1 0.0327 0.0244 0.0235
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0158 0.0031 0.0031
Schistosoma mansoni protein kinase 0.0234 0.0127 0.0385
Trypanosoma brucei rac serine-threonine kinase, putative 0.049 0.0448 0.4811
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0032 0.0308
Entamoeba histolytica protein kinase, putative 0.0168 0.0044 0.0166
Toxoplasma gondii aurora kinase 0.0347 0.0269 0.2867
Loa Loa (eye worm) hypothetical protein 0.1193 0.1333 0.1333
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1941 0.2273 0.7084
Schistosoma mansoni serine/threonine protein kinase 0.0871 0.0928 0.289
Brugia malayi Protein kinase domain containing protein 0.0147 0.0017 0.0009
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0293 0.02 0.058
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0223 0.0113 0.0113
Entamoeba histolytica protein kinase domain containing protein 0.0176 0.0054 0.0205
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0169 0.0045 0.0442
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0421 0.0362 0.0661
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.0044 0.0125
Giardia lamblia Kinase, PLK 0.0352 0.0275 0.2908
Echinococcus granulosus protein tyrosine kinase 0.0644 0.0642 0.1965
Brugia malayi Protein kinase domain containing protein 0.049 0.0448 0.044
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0236 0.0129 0.0358
Echinococcus multilocularis cyclin dependent kinase 0.0871 0.0928 0.174
Entamoeba histolytica PH domain containing protein kinase, putative 0.0261 0.016 0.0611
Onchocerca volvulus 0.0216 0.0104 0.016
Trichomonas vaginalis AGC family protein kinase 0.0405 0.0342 0.362
Loa Loa (eye worm) gastrulation defective protein 1 0.0546 0.0519 0.0519
Schistosoma mansoni serine/threonine protein kinase 0.0821 0.0864 0.269
Brugia malayi Protein kinase domain containing protein 0.0216 0.0104 0.0096
Schistosoma mansoni serine/threonine protein kinase 0.0351 0.0274 0.0844
Brugia malayi Kinase associated domain 1 family protein 0.024 0.0134 0.0125
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0036
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0508 0.0471 0.5062
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0821 0.0864 0.9311
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0159 0.0032 0.0032
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0032 0.0308
Loa Loa (eye worm) hypothetical protein 0.0256 0.0154 0.0154
Entamoeba histolytica protein kinase domain containing protein 0.0765 0.0794 0.3027
Onchocerca volvulus 0.0395 0.033 0.0876
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0517 0.0483 0.0891
Brugia malayi Temporarily assigned gene name protein 59 0.0508 0.0471 0.0463
Brugia malayi Protein kinase domain containing protein 0.205 0.241 0.2404
Schistosoma mansoni protein kinase 0.0185 0.0065 0.0191
Trichomonas vaginalis CAMK family protein kinase 0.0782 0.0815 0.8684
Loa Loa (eye worm) hypothetical protein 0.0646 0.0645 0.0645
Echinococcus granulosus serine:threonine protein kinase 0.0159 0.0032 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.2255 0.2667 0.8329
Echinococcus multilocularis calcium dependent protein kinase 0.0208 0.0094 0.015
Trichomonas vaginalis CAMK family protein kinase 0.0222 0.0111 0.1147
Brugia malayi Protein kinase domain containing protein 0.0242 0.0136 0.0128
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0327 0.0244 0.0235
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0347 0.0269 0.1024
Trichomonas vaginalis AGC family protein kinase 0.049 0.0448 0.4758
Echinococcus multilocularis casein kinase I alpha 0.0351 0.0274 0.0492
Echinococcus multilocularis activin receptor type 0.1 0.1089 0.2047
Brugia malayi serine/threonine-protein kinase 6 0.0347 0.0269 0.026
Echinococcus granulosus TGF beta receptor type 1 0.0269 0.017 0.0485
Loa Loa (eye worm) hypothetical protein 0.0249 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0462 0.0413 0.0413
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0474 0.0429 0.0788
Echinococcus granulosus casein kinase i 0.0351 0.0274 0.081
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0862 0.0917 0.2855
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0169 0.0045 0.0442
Brugia malayi Protein kinase domain containing protein 0.0247 0.0142 0.0134
Loa Loa (eye worm) AUR protein kinase 0.0347 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0229 0.012 0.012
Trypanosoma cruzi NIMA-related kinase, putative 0.0139 0.0007 0.0038
Brugia malayi Immunoglobulin I-set domain containing protein 0.1367 0.1552 0.1544
Plasmodium falciparum calcium-dependent protein kinase 3 0.0327 0.0244 0.2597
Loa Loa (eye worm) hypothetical protein 0.0508 0.0471 0.0471
Entamoeba histolytica protein kinase, putative 0.0327 0.0244 0.0929
Echinococcus multilocularis NCK adaptor protein 0.0163 0.0038 0.0042
Plasmodium vivax tyrosine kinase-like protein, putative 0.0166 0.0041 0.0406
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0421 0.0362 0.1088
Echinococcus multilocularis serine:threonine protein kinase 38 0.0348 0.027 0.0485
Brugia malayi P38 map kinase family protein 2 0.0506 0.0469 0.0461
Schistosoma mansoni protein kinase 0.0215 0.0103 0.0309
Echinococcus multilocularis mitogen activated protein kinase 11 0.0506 0.0469 0.0865
Loa Loa (eye worm) hypothetical protein 0.0426 0.0368 0.0368
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0573 0.0553 0.1686
Trichomonas vaginalis AGC family protein kinase 0.0176 0.0054 0.0538
Echinococcus granulosus twitchin 0.0435 0.0379 0.114
Trichomonas vaginalis AGC family protein kinase 0.0176 0.0054 0.0538
Echinococcus granulosus tyrosine protein kinase Srms 0.0617 0.0609 0.1862
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0234 0.0127 0.1333
Schistosoma mansoni tyrosine kinase 0.1105 0.1222 0.381
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0678 0.0684 0.0684
Echinococcus granulosus roundabout 2 0.0366 0.0292 0.0868
Entamoeba histolytica PH domain containing protein kinase, putative 0.0261 0.016 0.0611
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0327 0.0244 0.0244
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.0108 0.0325
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0185 0.0065 0.0065
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0156 0.0029 0.0041
Echinococcus multilocularis cyclin dependent kinase 5 0.0871 0.0928 0.174
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0223 0.0113 0.1182
Trichomonas vaginalis CMGC family protein kinase 0.0169 0.0045 0.0437
Entamoeba histolytica protein kinase, putative 0.0348 0.027 0.1028
Brugia malayi Protein kinase domain containing protein 0.0248 0.0144 0.0136
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0798 0.0835 0.2573
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0232 0.0124 0.1303
Echinococcus granulosus dual specificity mitogen activated protein 0.0429 0.0371 0.1116
Schistosoma mansoni serine/threonine protein kinase 0.0678 0.0684 0.2129
Echinococcus multilocularis expressed protein 0.0168 0.0044 0.0054
Schistosoma mansoni hypothetical protein 0.024 0.0134 0.0407
Brugia malayi Fibronectin type III domain containing protein 0.027 0.0171 0.0163
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0159 0.0032 0.0032
Loa Loa (eye worm) CDC7 protein kinase 0.0879 0.0938 0.0938
Trichomonas vaginalis AGC family protein kinase 0.049 0.0448 0.4758
Brugia malayi cyclin-dependent kinase 7 homolog 0.0735 0.0757 0.0749
Brugia malayi serine/threonine kinase 12 0.0347 0.0269 0.026
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0863 0.0917 0.9883
Brugia malayi Immunoglobulin I-set domain containing protein 0.0577 0.0558 0.055
Onchocerca volvulus 0.0426 0.0368 0.0999
Trichomonas vaginalis AGC family protein kinase 0.0167 0.0042 0.0407
Trichomonas vaginalis CK1 family protein kinase 0.0351 0.0274 0.2889
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.1349 0.1529 0.2885
Giardia lamblia Kinase, CAMK CAMKL 0.0176 0.0054 0.0538
Giardia lamblia Kinase, AGC PKA 0.0241 0.0135 0.1403
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0036
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.0054 0.0538
Brugia malayi Casein kinase II, alpha chain 0.0185 0.0065 0.0056
Echinococcus multilocularis TGF beta receptor type 1 0.0269 0.017 0.0295
Trichomonas vaginalis CMGC family protein kinase 0.0879 0.0938 1
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0036
Echinococcus granulosus serine/threonine protein kinase 0.0261 0.016 0.0454
Trypanosoma brucei protein kinase, putative 0.0139 0.0007 0.0038
Trichomonas vaginalis CMGC family protein kinase 0.0223 0.0113 0.1169
Trichomonas vaginalis AGC family protein kinase 0.049 0.0448 0.4758
Echinococcus granulosus Immunoglobulin 0.0256 0.0154 0.0436
Leishmania major serine/threonine kinase-like protein, putative 0.0176 0.0054 0.0544
Leishmania major protein kinase A catalytic subunit isoform 1 0.0821 0.0864 0.9311
Loa Loa (eye worm) hypothetical protein 0.0347 0.0268 0.0268
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0387 0.0319 0.0311
Brugia malayi probable protein kinase 0.1312 0.1482 0.1475
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Echinococcus multilocularis cyclin dependent kinase 1 0.0871 0.0928 0.174
Schistosoma mansoni adapter molecule crk 0.0158 0.0031 0.0085
Brugia malayi casein kinase 1, delta 0.0351 0.0274 0.0265
Trichomonas vaginalis CAMK family protein kinase 0.0352 0.0275 0.2908
Loa Loa (eye worm) TK/FER protein kinase 0.0216 0.0104 0.0104
Trichomonas vaginalis CMGC family protein kinase 0.0223 0.0113 0.1169
Loa Loa (eye worm) TK/FER protein kinase 0.0216 0.0104 0.0104
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.1051 0.1154 0.1154
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0347 0.0269 0.0795
Brugia malayi bone morphogenetic protein type 1 receptor 0.0265 0.0166 0.0157
Trichomonas vaginalis CAMK family protein kinase 0.0352 0.0275 0.2908
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0983 0.1068 0.3303
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0384 0.0316 0.0307
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.014 0.0009 0.0009
Loa Loa (eye worm) AUR protein kinase 0.0347 0.0269 0.0269
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0139 0.0007 0.0038
Toxoplasma gondii protein kinase domain-containing protein 0.0139 0.0007 0.0038
Plasmodium falciparum calcium-dependent protein kinase 5 0.0327 0.0244 0.2597
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0327 0.0244 0.2597
Brugia malayi Protein kinase domain containing protein 0.0368 0.0295 0.0287
Brugia malayi serine/threonine protein kinase 6 0.0347 0.0269 0.026
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0603 0.0591 0.0582
Trichomonas vaginalis CMGC family protein kinase 0.0863 0.0917 0.9775
Entamoeba histolytica protein kinase, putative 0.0156 0.0029 0.0109
Entamoeba histolytica protein kinase 2, putative 0.0241 0.0135 0.0513
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0821 0.0864 0.9311
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0234 0.0127 0.1333
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.014 0.0009 0.0052
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0613 0.0604 0.1846
Echinococcus granulosus dual specificity 0.0223 0.0113 0.0306
Schistosoma mansoni tyrosine kinase 0.0212 0.0098 0.0296
Schistosoma mansoni serine/threonine protein kinase 0.0399 0.0334 0.1032
Brugia malayi Variant SH3 domain containing protein 0.0158 0.0031 0.0022
Plasmodium falciparum serine/threonine protein kinase KIN 0.0222 0.0111 0.1159
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0821 0.0864 0.1618
Giardia lamblia Kinase, CMGC GSK 0.0862 0.0917 0.9772
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0032 0.0308
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0032 0.0308
Schistosoma mansoni kinase 0.0371 0.0298 0.0921
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0168 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0193 0.0076 0.0076
Schistosoma mansoni protein kinase 0.0351 0.0274 0.0844
Giardia lamblia Kinase, CK1 Casein kinase 0.0351 0.0274 0.2889
Echinococcus granulosus tyrosine protein kinase Src64B 0.0421 0.0362 0.1088
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0159 0.0032 0.0308
Onchocerca volvulus 0.0216 0.0104 0.016
Echinococcus multilocularis transfer RNA-Thr 0.0462 0.0413 0.0758
Trypanosoma cruzi cdc2-related kinase 1 0.0871 0.0928 1
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.2255 0.2667 0.8323
Loa Loa (eye worm) TK/INSR protein kinase 0.0784 0.0818 0.0818
Echinococcus multilocularis tyrosine protein kinase shark 0.1105 0.1222 0.23
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0166 0.0041 0.0406
Schistosoma mansoni serine/threonine protein kinase 0.0223 0.0113 0.0342
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0249 0.0145 0.0407
Giardia lamblia Kinase, NEK 0.022 0.0109 0.1132
Schistosoma mansoni serine/threonine protein kinase 0.0446 0.0394 0.1219
Loa Loa (eye worm) hypothetical protein 0.0257 0.0156 0.0156
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0399 0.0334 0.0998
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0168 0.0044 0.0434
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0222 0.0111 0.1147
Giardia lamblia Kinase, CDC7 0.0879 0.0938 1
Entamoeba histolytica protein kinase, putative 0.0156 0.0029 0.0109
Echinococcus granulosus dual specificity 0.0765 0.0794 0.2444
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Brugia malayi Immunoglobulin I-set domain containing protein 0.027 0.0171 0.0163
Brugia malayi Doublecortin family protein 0.0235 0.0128 0.0119
Echinococcus granulosus dual specificity protein kinase clk2 0.0863 0.0917 0.283
Brugia malayi p70 ribosomal S6 kinase beta 0.047 0.0423 0.0415
Trichomonas vaginalis STE family protein kinase 0.0236 0.0129 0.1346
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.2255 0.2667 0.8302
Brugia malayi MAP kinase sur-1 0.0169 0.0045 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0222 0.0111 0.1147
Entamoeba histolytica protein kinase domain containing protein 0.0234 0.0127 0.0483
Echinococcus multilocularis tyrosine protein kinase Abl 0.0352 0.0274 0.0494
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0421 0.0362 0.0661
Schistosoma mansoni serine/threonine protein kinase 0.0665 0.0668 0.2078
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0032 0.0308
Giardia lamblia Kinase, CMGC CDK 0.0871 0.0928 0.9891
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0352 0.0275 0.294
Trichomonas vaginalis CMGC family protein kinase 0.0862 0.0917 0.9772
Brugia malayi Hr1 repeat family protein 0.1015 0.1109 0.1102
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0242 0.0136 0.0136
Brugia malayi casein kinase I 0.0351 0.0274 0.0265
Leishmania major casein kinase, putative 0.0351 0.0274 0.2921
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0241 0.0135 0.1418
Trichomonas vaginalis AGC family protein kinase 0.0167 0.0042 0.0407
Giardia lamblia Kinase, STE STE20 0.0334 0.0252 0.2662
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.022 0.0109 0.1144
Plasmodium falciparum NIMA related kinase 1 0.022 0.0109 0.1144
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0702 0.0715 0.2194
Schistosoma mansoni tyrosine kinase 0.0474 0.0428 0.1328
Echinococcus granulosus casein kinase I alpha 0.0351 0.0274 0.081
Brugia malayi serine/threonine-protein kinase plk-2 0.0352 0.0275 0.0267
Brugia malayi Serine/threonine-protein kinase Pim-3 0.2255 0.2667 0.2661
Echinococcus granulosus cyclin dependent kinase 5 0.0871 0.0928 0.2863
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0032 0.0308
Echinococcus granulosus protein kinase c iota type 0.0518 0.0484 0.147
Brugia malayi Egg laying defective protein 4 0.0219 0.0108 0.0099
Echinococcus granulosus CDC7 cell division cycle 7 0.0879 0.0938 0.2895
Trichomonas vaginalis CK1 family protein kinase 0.0351 0.0274 0.2889
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0248 0.0144 0.0403
Loa Loa (eye worm) TK protein kinase 0.0243 0.0138 0.0138
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0862 0.0917 0.2829
Plasmodium falciparum protein kinase, putative 0.0234 0.0127 0.1333
Entamoeba histolytica hypothetical protein 0.0765 0.0794 0.3027
Brugia malayi Homeodomain interacting protein kinase protein 1 0.2219 0.2623 0.2617
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0189 0.007 0.0105
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0158 0.0031 0.0031
Echinococcus multilocularis serine:threonine protein kinase 3 0.1051 0.1154 0.2171
Schistosoma mansoni protein kinase 0.0347 0.0269 0.0829
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0508 0.0471 0.1463
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0139 0.0007 0.0038
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0387 0.0319 0.0319
Trichomonas vaginalis CAMK family protein kinase 0.0211 0.0097 0.1002
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0295 0.0203 0.0203
Trichomonas vaginalis CMGC family protein kinase 0.0185 0.0065 0.0654
Schistosoma mansoni serine/threonine protein kinase 0.0871 0.0928 0.289
Echinococcus multilocularis insulin receptor 0.0784 0.0818 0.1531
Echinococcus multilocularis activated cdc42 kinase 1 0.0462 0.0413 0.0758
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Brugia malayi Protein kinase domain containing protein 0.1422 0.162 0.1613
Onchocerca volvulus 0.0216 0.0104 0.016
Echinococcus multilocularis casein kinase I gamma 0.0296 0.0205 0.0361
Brugia malayi Protein kinase domain containing protein 0.0216 0.0104 0.0096
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0189 0.007 0.0172
Brugia malayi Furin-like cysteine rich region family protein 0.0794 0.0831 0.0823
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0863 0.0917 0.9883
Schistosoma mansoni tyrosine kinase 0.0212 0.0098 0.0296
Echinococcus multilocularis rac serine:threonine kinase 0.0261 0.016 0.0276
Loa Loa (eye worm) TK/FER protein kinase 0.0216 0.0104 0.0104
Entamoeba histolytica protein kinase domain containing protein 0.0446 0.0394 0.15
Giardia lamblia Kinase, CMGC CLK 0.0863 0.0917 0.9775
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0037
Echinococcus granulosus cGMP dependent protein kinase 1 0.0219 0.0108 0.0289
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0798 0.0835 0.1563
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0159 0.0032 0.0308
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0222 0.0111 0.1159
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0352 0.0275 0.0816
Echinococcus multilocularis mitogen activated protein kinase 11 0.0506 0.0469 0.0865
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0474 0.0429 0.0429
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Trichomonas vaginalis serine/threonine-protein kinase ypk, putative 0.0139 0.0007 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0477 0.0432 0.1339
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Echinococcus multilocularis tyrosine protein kinase HCK 0.0263 0.0163 0.0282
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0821 0.0864 0.1618
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0765 0.0794 0.8552
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0863 0.0917 0.9883
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0032 0.0308
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.1022 0.1117 0.111
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0219 0.0108 0.1123
Schistosoma mansoni vav2 0.021 0.0096 0.0288
Trichomonas vaginalis CAMK family protein kinase 0.0542 0.0513 0.5455
Leishmania major protein kinase, putative 0.0139 0.0007 0.0038
Echinococcus granulosus tyrosine protein kinase Fyn 0.0421 0.0362 0.1088
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Echinococcus multilocularis serine:threonine protein kinase 0.0159 0.0032 0.0031
Loa Loa (eye worm) TK protein kinase 0.0263 0.0163 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0036
Loa Loa (eye worm) hypothetical protein 0.027 0.0171 0.0171
Loa Loa (eye worm) TK/EGFR protein kinase 0.0794 0.0831 0.0831
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0032 0.0308
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0219 0.0108 0.0176
Entamoeba histolytica hypothetical protein 0.0139 0.0007 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.014 0.0009 0.0015
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0863 0.0917 0.9883
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0821 0.0864 0.2664
Echinococcus multilocularis protein tyrosine kinase 0.0644 0.0642 0.1194
Loa Loa (eye worm) hypothetical protein 0.0293 0.02 0.02
Schistosoma mansoni protein kinase 0.1349 0.1529 0.4768
Schistosoma mansoni serine/threonine protein kinase 0.0399 0.0334 0.1032
Entamoeba histolytica protein kinase domain containing protein 0.2219 0.2623 1
Loa Loa (eye worm) hypothetical protein 0.0426 0.0368 0.0368
Leishmania major protein kinase, putative 0.0347 0.0269 0.2867
Echinococcus multilocularis rho associated protein kinase 0.268 0.3202 0.6075
Trichomonas vaginalis CK1 family protein kinase 0.0351 0.0274 0.2889
Trichomonas vaginalis CAMK family protein kinase 0.0159 0.0032 0.0302
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0265 0.0166 0.0166
Entamoeba histolytica protein kinase, putative 0.0139 0.0007 0.0027
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0256 0.0154 0.0471
Trichomonas vaginalis CAMK family protein kinase 0.0222 0.0111 0.1147
Echinococcus granulosus c src tyrosine kinase 0.0274 0.0176 0.0504
Trypanosoma cruzi cdc2-related kinase 1 0.0871 0.0928 1
Brugia malayi Protein kinase domain containing protein 0.0325 0.024 0.0232
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0517 0.0483 0.1467
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0508 0.0471 0.5062
Trichomonas vaginalis CAMK family protein kinase 0.0222 0.0111 0.1147
Echinococcus granulosus serine:threonine protein kinase N2 0.1015 0.1109 0.3432
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0821 0.0864 0.2664
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0821 0.0864 0.9311
Brugia malayi ephrin receptor 1 precursor 0.0145 0.0015 0.0006
Loa Loa (eye worm) SRC-1 0.0421 0.0362 0.0362
Brugia malayi Protein kinase domain containing protein 0.0167 0.0042 0.0033
Trichomonas vaginalis STE family protein kinase 0.0236 0.0129 0.1346
Echinococcus multilocularis protein kinase c iota type 0.0518 0.0484 0.0893
Plasmodium vivax calcium-dependent protein kinase, putative 0.0327 0.0244 0.2597
Loa Loa (eye worm) TK/EPH protein kinase 0.0196 0.0078 0.0078
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0229 0.012 0.0329
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0871 0.0928 1
Onchocerca volvulus 0.0216 0.0104 0.016
Schistosoma mansoni protein kinase 0.0236 0.0129 0.0393
Brugia malayi Protein kinase domain containing protein 0.0296 0.0205 0.0196
Trichomonas vaginalis AGC family protein kinase 0.0821 0.0864 0.9209
Echinococcus multilocularis tyrosine protein kinase Blk 0.0364 0.029 0.0523
Schistosoma mansoni growth factor receptor-bound protein 0.0158 0.0031 0.0085
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Schistosoma mansoni protein kinase C mu 0.0603 0.0591 0.1835
Echinococcus granulosus cyclin dependent kinase 9 0.0504 0.0466 0.1414
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0139 0.0007 0.0038
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0176 0.0054 0.0544
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0185 0.0065 0.0662
Echinococcus multilocularis hypothetical protein 0.024 0.0134 0.0226
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0863 0.0917 0.9883
Echinococcus multilocularis dual specificity 0.0223 0.0113 0.0186
Schistosoma mansoni serine/threonine kinase 0.0348 0.027 0.0832
Schistosoma mansoni serine/threonine protein kinase 0.0359 0.0283 0.0875
Echinococcus granulosus tyrosine protein kinase Fyn 0.0421 0.0362 0.1088
Schistosoma mansoni tyrosine kinase 0.0421 0.0362 0.112
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0241 0.0135 0.0228
Loa Loa (eye worm) AGC/AKT protein kinase 0.049 0.0448 0.0448
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0421 0.0362 0.0661
Echinococcus granulosus serine:threonine protein kinase N2 0.0667 0.0672 0.2059
Entamoeba histolytica protein kinase, putative 0.049 0.0448 0.1709
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0862 0.0917 0.0917
Loa Loa (eye worm) hypothetical protein 0.0159 0.0032 0.0032
Onchocerca volvulus 0.205 0.241 0.7486
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0139 0.0007 0.0038
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.1079 0.1189 0.1189
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0347 0.0269 0.1024
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0139 0.0007 0.0038
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.0176 0.0054 0.0073
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0167 0.0042 0.0042
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0862 0.0917 0.0917
Brugia malayi Variant SH3 domain containing protein 0.0189 0.007 0.0062
Entamoeba histolytica protein kinase, putative 0.022 0.0108 0.0413
Brugia malayi Protein kinase domain containing protein 0.0462 0.0413 0.0405
Entamoeba histolytica protein kinase, putative 0.0168 0.0044 0.0166
Leishmania major serine/threonine-protein kinase a, putative 0.0139 0.0007 0.0038
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0514 0.0479 0.0479
Trypanosoma cruzi casein kinase, putative 0.0351 0.0274 0.2921
Schistosoma mansoni hypothetical protein 0.024 0.0134 0.0407
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0036
Trichomonas vaginalis serine/threonine-protein kinase, putative 0.0139 0.0007 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0037
Trichomonas vaginalis AGC family protein kinase 0.049 0.0448 0.4758
Brugia malayi Protein kinase domain 0.0236 0.0129 0.0121
Echinococcus granulosus rho-associated protein kinase 1 0.268 0.3202 1
Echinococcus granulosus neuroglian 0.0316 0.0229 0.0671
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0327 0.0244 0.0716
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0169 0.0045 0.0442
Giardia lamblia Kinase, STE STE20 0.0236 0.0129 0.1346
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0036
Echinococcus multilocularis casein kinase I alpha 0.0351 0.0274 0.0492
Trichomonas vaginalis CAMK family protein kinase 0.0222 0.0111 0.1147
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0528 0.0496 0.0496
Trichomonas vaginalis AGC family protein kinase 0.0368 0.0295 0.3118
Schistosoma mansoni serine/threonine protein kinase 0.0613 0.0604 0.1876
Trichomonas vaginalis AGC family protein kinase 0.0224 0.0114 0.118
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.0054 0.0538
Schistosoma mansoni atypical protein kinase C 0.0524 0.0491 0.1525
Schistosoma mansoni tyrosine kinase 0.0274 0.0176 0.0539
Echinococcus granulosus casein kinase I gamma 0.0296 0.0205 0.0594
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0036
Onchocerca volvulus 0.0216 0.0104 0.016
Loa Loa (eye worm) TK/FER protein kinase 0.0216 0.0104 0.0104
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0175 0.0052 0.007
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0327 0.0244 0.2597
Trichomonas vaginalis CAMK family protein kinase 0.0211 0.0097 0.1002
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0348 0.027 0.0485
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0037
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0446 0.0394 0.0394
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0223 0.0113 0.1182
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0627 0.0621 0.19
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.0057 0.0165
Brugia malayi Protein kinase domain containing protein 0.065 0.065 0.0642
Echinococcus multilocularis casein kinase I alpha 0.0351 0.0274 0.0492
Entamoeba histolytica protein kinase, putative 0.049 0.0448 0.1709
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0236 0.0129 0.0217
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0983 0.1068 0.2006
Trichomonas vaginalis CAMK family protein kinase 0.0542 0.0513 0.5455
Loa Loa (eye worm) hypothetical protein 0.0504 0.0466 0.0466
Echinococcus multilocularis serine:threonine protein kinase N2 0.0667 0.0672 0.1251
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.022 0.0109 0.1144
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.0054 0.0538
Schistosoma mansoni vesicular amine transporter 0.0256 0.0154 0.0471
Schistosoma mansoni tyrosine kinase 0.1004 0.1095 0.3413
Giardia lamblia Kinase, CMGC SRPK 0.0168 0.0044 0.0429
Echinococcus granulosus cyclin dependent kinase 0.0871 0.0928 0.2863
Echinococcus granulosus serine:threonine protein kinase mig 15 0.1193 0.1333 0.4134
Loa Loa (eye worm) hypothetical protein 0.027 0.0171 0.0171
Schistosoma mansoni serine/threonine protein kinase 0.0879 0.0938 0.2922
Echinococcus granulosus c-Jun N-terminal kinases 0.0829 0.0875 0.2698
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0871 0.0928 1
Schistosoma mansoni serine/threonine protein kinase 0.0765 0.0794 0.2471
Echinococcus granulosus ephrin type A receptor 4 A 0.0178 0.0057 0.0129
Schistosoma mansoni serine/threonine-protein kinase 0.0261 0.016 0.049
Echinococcus granulosus cyclin dependent kinase 19 0.0665 0.0668 0.2049
Brugia malayi Protein kinase domain containing protein 0.0176 0.0054 0.0045
Plasmodium vivax serine/threonine kinase-1, putative 0.0863 0.0917 0.9883
Echinococcus multilocularis dual specificity protein kinase clk2 0.0863 0.0917 0.1719
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0261 0.016 0.1694
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0429 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0774 0.0806 0.0806
Loa Loa (eye worm) TK/ALK protein kinase 0.1421 0.1619 0.1619
Loa Loa (eye worm) CAMK/PIM protein kinase 0.2255 0.2667 0.2667
Echinococcus granulosus tyrosine kinase 0.0364 0.029 0.0861
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Trichomonas vaginalis CAMK family protein kinase 0.0222 0.0111 0.1147
Trichomonas vaginalis CMGC family protein kinase 0.0871 0.0928 0.9891
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.8085 1 1
Onchocerca volvulus 0.0216 0.0104 0.016
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0765 0.0794 0.8552
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0156 0.0029 0.0025
Echinococcus granulosus titin 0.0192 0.0074 0.0182
Trichomonas vaginalis AGC family protein kinase 0.0347 0.0269 0.2836
Onchocerca volvulus 0.0508 0.0471 0.1327
Schistosoma mansoni tyrosine kinase 0.032 0.0234 0.072
Echinococcus granulosus cGMP dependent protein kinase 0.0219 0.0108 0.0289
Schistosoma mansoni protein kinase 0.0265 0.0166 0.0507
Loa Loa (eye worm) TK/FER protein kinase 0.0216 0.0104 0.0104
Schistosoma mansoni serine/threonine protein kinase 0.0438 0.0383 0.1185
Brugia malayi Serine/threonine-protein kinase SULU 0.07 0.0713 0.0705
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0677 0.0684 0.0684
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0248 0.0144 0.0144
Plasmodium vivax glycogen synthase kinase 3, putative 0.0862 0.0917 0.988
Brugia malayi Sex muscle abnormal protein 5 0.0158 0.0031 0.0022
Entamoeba histolytica protein kinase domain containing protein 0.0862 0.0917 0.3495
Schistosoma mansoni cell adhesion molecule 0.0306 0.0217 0.0667
Plasmodium falciparum calcium-dependent protein kinase 7 0.0139 0.0007 0.0038
Entamoeba histolytica protein kinase, putative 0.0263 0.0163 0.0622
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0344 0.0265 0.0783
Trichomonas vaginalis CAMK family protein kinase 0.0352 0.0275 0.2908
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0032 0.0308
Schistosoma mansoni protein kinase 0.1552 0.1784 0.5566
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0189 0.007 0.007
Entamoeba histolytica protein kinase domain containing protein 0.0223 0.0113 0.043
Brugia malayi Protein kinase domain containing protein 0.0765 0.0794 0.0786
Echinococcus granulosus N chimaerin 0.0189 0.007 0.0172
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0167 0.0042 0.0083
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.0074 0.0218
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0821 0.0864 0.9311
Echinococcus granulosus protein kinase C gamma type 0.0388 0.032 0.0957
Schistosoma mansoni titin 0.0192 0.0074 0.0218
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0351 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0677 0.0684 0.0684
Loa Loa (eye worm) hypothetical protein 0.0216 0.0104 0.0104
Onchocerca volvulus Serine\/threonine kinase homolog 0.0352 0.0275 0.0704
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0573 0.0553 0.1024
Brugia malayi map kinase activated protein kinase protein 2 0.0474 0.0429 0.0421
Loa Loa (eye worm) haspin protein kinase 0.0176 0.0054 0.0054
Schistosoma mansoni serine/threonine protein kinase 0.0474 0.0429 0.1329
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0821 0.0864 0.0856
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0764 0.0792 0.2438
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0222 0.0111 0.0111
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0862 0.0917 0.1718
Entamoeba histolytica PH domain containing protein kinase, putative 0.0139 0.0007 0.0027
Echinococcus multilocularis casein kinase I delta 0.0351 0.0274 0.0492
Plasmodium falciparum protein serine/threonine kinase-1 0.0863 0.0917 0.9883
Plasmodium vivax unspecified product 0.0185 0.0065 0.0662
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.036 0.0285 0.0277
Echinococcus granulosus NCK adaptor protein 0.0158 0.0031 0.0049
Echinococcus granulosus epidermal growth factor receptor 0.0589 0.0574 0.1751
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0764 0.0792 0.1481
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0364 0.029 0.0861
Loa Loa (eye worm) TK/FER protein kinase 0.0216 0.0104 0.0104
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0222 0.0111 0.1159
Schistosoma mansoni protein kinase 0.1349 0.1529 0.4768
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0241 0.0135 0.1418
Trypanosoma cruzi casein kinase, putative 0.0351 0.0274 0.2921
Loa Loa (eye worm) hypothetical protein 0.0508 0.0471 0.0471
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0216 0.0104 0.0396
Echinococcus multilocularis dual specificity 0.0223 0.0113 0.0186
Loa Loa (eye worm) hypothetical protein 0.0291 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0752 0.0778 0.0778
Echinococcus granulosus mitogen activated protein kinase 14 0.0506 0.0469 0.1424
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0139 0.0007 0.0038
Entamoeba histolytica protein kinase, putative 0.0765 0.0794 0.3027
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0429 0.0371 0.3976
Schistosoma mansoni serine/threonine protein kinase 0.2405 0.2856 0.8919
Echinococcus multilocularis neuroglian 0.0316 0.0229 0.0407
Echinococcus multilocularis twitchin 0.0178 0.0057 0.0079
Brugia malayi Stress-activated protein kinase jnk-1 0.0829 0.0875 0.0867
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0334 0.0252 0.2691
Schistosoma mansoni serine/threonine protein kinase 0.0167 0.0042 0.0119
Echinococcus multilocularis growth factor receptor bound protein 2 0.0158 0.0031 0.003
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0256 0.0154 0.0265
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.0015 0.0037
Echinococcus granulosus activin receptor type 0.1 0.1089 0.337
Brugia malayi Tyrosine-protein kinase abl-1 0.0352 0.0274 0.0266
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0334 0.0252 0.0962
Trichomonas vaginalis CMGC family protein kinase 0.0879 0.0938 1
Trichomonas vaginalis AGC family protein kinase 0.049 0.0448 0.4758
Echinococcus multilocularis epidermal growth factor receptor 0.0589 0.0574 0.1064
Giardia lamblia Kinase, STE STE20 0.0429 0.0371 0.3933
Schistosoma mansoni serine/threonine protein kinase 0.0348 0.027 0.0832
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.1552 0.1784 0.5549
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0327 0.0244 0.0716
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0421 0.0362 0.0661
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0348 0.027 0.0485
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0327 0.0244 0.2597
Entamoeba histolytica protein kinase, putative 0.0347 0.0269 0.1024
Loa Loa (eye worm) hypothetical protein 0.0508 0.0471 0.0471
Echinococcus granulosus aurora kinase A 0.0347 0.0269 0.0795
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0518 0.0483 0.0892
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0269 0.017 0.0295
Loa Loa (eye worm) AGC/PKG protein kinase 0.0219 0.0108 0.0108
Echinococcus granulosus tyrosine protein kinase Blk 0.0364 0.029 0.0861
Echinococcus multilocularis calcium activated potassium channel 0.0359 0.0283 0.0511
Loa Loa (eye worm) TK/ABL protein kinase 0.042 0.0361 0.0361
Brugia malayi protein-tyrosine kinase 0.0364 0.029 0.0282
Echinococcus granulosus tyrosine protein kinase Src42A 0.0421 0.0362 0.1088
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0219 0.0108 0.0176
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0235 0.0128 0.0128
Echinococcus multilocularis mitogen activated protein kinase 14 0.0506 0.0469 0.0865
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0148 0.0018 0.0018
Trichomonas vaginalis STE family protein kinase 0.0236 0.0129 0.1346
Onchocerca volvulus 0.0484 0.0441 0.123
Echinococcus granulosus cyclin dependent kinase 1 0.0871 0.0928 0.2863
Echinococcus multilocularis serine:threonine protein kinase N2 0.0348 0.027 0.0485
Echinococcus multilocularis aurora kinase A 0.0347 0.0269 0.0483
Schistosoma mansoni serine/threonine protein kinase 0.0348 0.027 0.0832
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0821 0.0864 0.1618
Plasmodium falciparum serine/threonine protein kinase, putative 0.0347 0.0269 0.2867
Loa Loa (eye worm) hypothetical protein 0.0327 0.0244 0.0244
Trichomonas vaginalis protein kinase atmrk1, putative 0.0176 0.0054 0.0538
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0351 0.0274 0.0274
Schistosoma mansoni serine/threonine protein kinase 0.2219 0.2623 0.8191
Schistosoma mansoni serine/threonine protein kinase 0.0764 0.0792 0.2466
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0821 0.0864 0.9311
Brugia malayi Protein kinase domain containing protein 0.0216 0.0104 0.0096
Onchocerca volvulus 0.0504 0.0466 0.1311
Loa Loa (eye worm) hypothetical protein 0.027 0.0171 0.0171
Trichomonas vaginalis CAMK family protein kinase 0.0222 0.0111 0.1147
Echinococcus multilocularis titin 0.0192 0.0074 0.0111
Entamoeba histolytica protein kinase, putative 0.0235 0.0128 0.0488
Echinococcus granulosus casein kinase I alpha 0.0351 0.0274 0.081
Echinococcus multilocularis roundabout 2 0.0366 0.0292 0.0527
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0169 0.0045 0.0442
Entamoeba histolytica protein kinase domain containing protein 0.0862 0.0917 0.3495
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0821 0.0864 0.1618
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0327 0.0244 0.2597
Entamoeba histolytica protein kinase, putative 0.0765 0.0794 0.3027
Echinococcus multilocularis mitogen activated protein kinase 3 0.0169 0.0045 0.0056
Loa Loa (eye worm) TK/FER protein kinase 0.0216 0.0104 0.0104
Trichomonas vaginalis CMGC family protein kinase 0.0223 0.0113 0.1169
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0279 0.0183 0.1941
Brugia malayi Protein kinase domain containing protein 0.0407 0.0344 0.0335
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0327 0.0244 0.2597
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0139 0.0007 0.0038
Brugia malayi Protein kinase domain containing protein 0.0528 0.0496 0.0488
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Entamoeba histolytica protein kinase, putative 0.0139 0.0007 0.0027
Trichomonas vaginalis CMGC family protein kinase 0.0223 0.0113 0.1169
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Schistosoma mansoni kinase 0.0446 0.0394 0.1219
Trichomonas vaginalis CMGC family protein kinase 0.0871 0.0928 0.9891
Schistosoma mansoni serine/threonine protein kinase 0.268 0.3202 1
Trichomonas vaginalis CAMK family protein kinase 0.0222 0.0111 0.1147
Schistosoma mansoni serine/threonine protein kinase 0.0222 0.0111 0.0335
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0234 0.0127 0.1333
Giardia lamblia Kinase, CMGC DYRK 0.0223 0.0113 0.1169
Trichomonas vaginalis CAMK family protein kinase 0.0222 0.0111 0.1147
Brugia malayi SRC-1 0.0421 0.0362 0.0354
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0247 0.0142 0.0142
Onchocerca volvulus 0.0862 0.0917 0.2741
Schistosoma mansoni serine/threonine protein kinase 0.0284 0.0189 0.0581
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0863 0.0917 0.9883
Onchocerca volvulus Tyrosine kinase homolog 0.1134 0.1258 0.3827
Echinococcus granulosus calcium activated potassium channel 0.0359 0.0283 0.0841
Echinococcus granulosus casein kinase I delta 0.0351 0.0274 0.081
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0508 0.0471 0.1463
Brugia malayi Protein kinase domain containing protein 0.0871 0.0928 0.092
Leishmania major protein kinase, putative 0.0234 0.0127 0.1333
Loa Loa (eye worm) TK protein kinase 0.0364 0.029 0.029
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0821 0.0864 0.2664
Trypanosoma brucei protein kinase, putative 0.0234 0.0127 0.1333
Trichomonas vaginalis AGC family protein kinase 0.0347 0.0269 0.2836
Brugia malayi Protein kinase c protein 2 0.0248 0.0144 0.0135
Loa Loa (eye worm) AUR protein kinase 0.0347 0.0269 0.0269
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0829 0.0875 0.1639
Echinococcus granulosus mitogen activated protein kinase 15 0.0176 0.0054 0.0121
Echinococcus multilocularis c src tyrosine kinase 0.0274 0.0176 0.0306
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.036 0.0285 0.0847
Trypanosoma cruzi polo-like protein kinase, putative 0.0352 0.0275 0.294
Schistosoma mansoni tyrosine kinase 0.0474 0.0428 0.1328
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0429 0.0371 0.3976
Echinococcus multilocularis G protein coupled receptor kinase 6 0.036 0.0285 0.0514
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0665 0.0668 0.0668
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0815 0.0856 0.1603
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0421 0.0362 0.1088
Trichomonas vaginalis CMGC family protein kinase 0.0185 0.0065 0.0654
Echinococcus multilocularis protein kinase shaggy 0.0862 0.0917 0.1718
Entamoeba histolytica casein kinase 1, putative 0.0351 0.0274 0.1043
Echinococcus granulosus Cell division cycle 2 protein kinase 0.0176 0.0054 0.0121
Giardia lamblia Kinase, NEK 0.022 0.0109 0.1132
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0829 0.0875 0.0875
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0862 0.0917 0.988
Plasmodium falciparum serine/threonine protein kinase 0.0168 0.0044 0.0434
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0241 0.0135 0.1418
Trichomonas vaginalis AGC family protein kinase 0.0388 0.0321 0.3391
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0863 0.0917 0.0917
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0036
Echinococcus granulosus tyrosine protein kinase Src42A 0.0254 0.0151 0.0427
Trichomonas vaginalis CAMK family protein kinase 0.0222 0.0111 0.1147
Entamoeba histolytica hypothetical protein 0.0374 0.0303 0.1153
Trypanosoma brucei SNF1-related protein kinases, putative 0.0222 0.0111 0.1159
Echinococcus multilocularis mitogen activated protein kinase 14 0.0506 0.0469 0.0865
Trypanosoma brucei protein kinase, putative 0.0226 0.0117 0.1224
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0156 0.0029 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0863 0.0917 0.2856
Schistosoma mansoni serine/threonine protein kinase 0.07 0.0713 0.2217
Trypanosoma cruzi cdc2-related kinase 3 0.0871 0.0928 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.042 0.0361 0.1084
Echinococcus multilocularis cyclin dependent kinase 1 0.0871 0.0928 0.174
Schistosoma mansoni protein kinase 0.1312 0.1482 0.4623
Schistosoma mansoni serine/threonine protein kinase 0.0347 0.0269 0.0829
Entamoeba histolytica SH2-protein kinase domain containing protein 0.022 0.0108 0.0413
Trichomonas vaginalis AGC family protein kinase 0.049 0.0448 0.4758
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0506 0.0469 0.5035
Trypanosoma cruzi casein kinase II, putative 0.0185 0.0065 0.0662
Trichomonas vaginalis STE family protein kinase 0.0429 0.0371 0.3933
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0222 0.0111 0.1159
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0036
Brugia malayi protein unc-22 0.0192 0.0074 0.0065
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0256 0.0154 0.0471
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0352 0.0275 0.0496
Trichomonas vaginalis CAMK family protein kinase 0.0352 0.0275 0.2908
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0421 0.0362 0.0661
Echinococcus granulosus dual specificity 0.0223 0.0113 0.0306
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.0015 0.0037
Entamoeba histolytica PH domain containing protein kinase, putative 0.0841 0.089 0.3391
Loa Loa (eye worm) TK/FER protein kinase 0.0216 0.0104 0.0104
Brugia malayi hypothetical protein 0.0216 0.0104 0.0096
Echinococcus granulosus casein kinase I alpha 0.0351 0.0274 0.081
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0334 0.0252 0.2691
Schistosoma mansoni serine/threonine protein kinase 0.0296 0.0205 0.0629
Onchocerca volvulus 0.0192 0.0074 0.0063
Echinococcus granulosus tyrosine kinase 0.0216 0.0104 0.0278
Plasmodium falciparum MO15-related protein kinase 0.0176 0.0054 0.0544
Plasmodium falciparum cGMP-dependent protein kinase 0.0219 0.0108 0.1123
Schistosoma mansoni tyrosine kinase 0.0249 0.0145 0.0442
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0036
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0228 0.012 0.012
Schistosoma mansoni protein kinase 0.0276 0.018 0.055
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0176 0.0054 0.0544
Echinococcus granulosus serine:threonine protein kinase 0.0159 0.0032 0.0052
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0399 0.0334 0.0607
Schistosoma mansoni serine/threonine protein kinase 0.0477 0.0432 0.1339
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0677 0.0684 0.0684
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0518 0.0483 0.0483
Echinococcus multilocularis cyclin dependent kinase 19 0.0665 0.0668 0.1245
Schistosoma mansoni serine/threonine protein kinase 0.0764 0.0792 0.2466
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0871 0.0928 0.2863
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0765 0.0794 0.8552
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0032 0.0308
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0236 0.0129 0.0217
Trichomonas vaginalis AGC family protein kinase 0.049 0.0448 0.4758
Leishmania major mitogen-activated protein kinase, putative,map kinase-like protein 0.0176 0.0054 0.0544
Brugia malayi putative serine/threonine kinase SADA gamma 0.0222 0.0111 0.0102
Schistosoma mansoni serine/threonine protein kinase 0.0518 0.0483 0.1499
Trichomonas vaginalis STE family protein kinase 0.022 0.0109 0.1132
Schistosoma mansoni serine/threonine protein kinase 0.0821 0.0864 0.269
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.1552 0.1784 0.1784
Schistosoma mansoni ephrin receptor 0.0178 0.0057 0.0166
Echinococcus granulosus mitogen activated protein kinase 0.0169 0.0045 0.0091
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Echinococcus multilocularis serine threonine protein kinase 0.0388 0.032 0.0581
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.07 0.0713 0.0713
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0284 0.0189 0.0189
Trichomonas vaginalis G protein-coupled receptor kinase, putative 0.0176 0.0054 0.0538
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0169 0.0045 0.0442
Toxoplasma gondii CMGC kinase, CK2 family 0.0185 0.0065 0.0662
Plasmodium vivax casein kinase 1, putative 0.0351 0.0274 0.2921
Echinococcus granulosus serine:threonine protein kinase 3 0.1051 0.1154 0.3573
Brugia malayi SH2 domain containing protein 0.0344 0.0265 0.0257
Brugia malayi cell division control protein 2 homolog 0.0871 0.0928 0.092
Echinococcus multilocularis 0.0804 0.0843 0.1578
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0176 0.0054 0.0544
Schistosoma mansoni serine/threonine protein kinase 0.0169 0.0045 0.0128
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0032 0.0308
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0169 0.0045 0.0442
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0627 0.0621 0.1154
Schistosoma mansoni tyrosine kinase 0.0784 0.0818 0.2547
Schistosoma mansoni serine/threonine protein kinase 0.0248 0.0144 0.0439
Trichomonas vaginalis CMGC family protein kinase 0.0185 0.0065 0.0654
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Trichomonas vaginalis CMGC family protein kinase 0.0185 0.0065 0.0654
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0032 0.0308
Schistosoma mansoni serine/threonine protein kinase 0.0359 0.0283 0.0875
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0506 0.0469 0.5035
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.014 0.0009 0.0009
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0158 0.0031 0.0085
Echinococcus multilocularis protein KINase family member (kin 25) 0.0249 0.0145 0.0247
Leishmania major folate/biopterin transporter, putative 0.0139 0.0007 0.0038
Echinococcus multilocularis cyclin dependent kinase 9 0.0446 0.0394 0.0721
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0804 0.0843 0.0843
Schistosoma mansoni tyrosine kinase 0.0589 0.0574 0.1782
Schistosoma mansoni serine/threonine protein kinase 0.0821 0.0864 0.269
Trichomonas vaginalis CMGC family protein kinase 0.0185 0.0065 0.0654
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.0054 0.0538
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Leishmania major protein kinase, putative 0.0139 0.0007 0.0038
Echinococcus multilocularis PAK box P21 Rho binding 0.0215 0.0103 0.0166
Giardia lamblia Aurora kinase 0.0347 0.0269 0.2836
Trichomonas vaginalis CMGC family protein kinase 0.0879 0.0938 1
Trypanosoma brucei cdc2-related kinase 1 0.0871 0.0928 1
Schistosoma mansoni serine/threonine protein kinase 0.014 0.0009 0.0015
Brugia malayi Protein kinase domain containing protein 0.0216 0.0104 0.0096
Trichomonas vaginalis CMGC family protein kinase 0.0223 0.0113 0.1169
Brugia malayi cyclin-dependent kinase 9 0.0446 0.0394 0.0385
Giardia lamblia Kinase, NEK 0.022 0.0109 0.1132
Trichomonas vaginalis CAMK family protein kinase 0.0222 0.0111 0.1147
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0175 0.0052 0.0116
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0821 0.0864 0.9311
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0276 0.018 0.018
Brugia malayi Protein kinase domain containing protein 0.0216 0.0104 0.0096
Schistosoma mansoni serine/threonine protein kinase 0.0222 0.0111 0.0335
Trichomonas vaginalis CMGC family protein kinase 0.0223 0.0113 0.1169
Trichomonas vaginalis STE family protein kinase 0.0429 0.0371 0.3933
Entamoeba histolytica protein kinase, putative 0.0862 0.0917 0.3495
Echinococcus granulosus activated cdc42 kinase 1 0.0462 0.0413 0.1248
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0364 0.029 0.0523
Echinococcus granulosus expressed protein 0.0168 0.0044 0.0089
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0169 0.0045 0.0442
Entamoeba histolytica serine/threonine protein kinase, putative 0.0352 0.0275 0.105
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0192 0.0074 0.0074
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0334 0.0252 0.0962
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Echinococcus multilocularis tyrosine kinase 0.0216 0.0104 0.0169
Echinococcus multilocularis dual specificity mitogen activated protein 0.0429 0.0371 0.0678
Schistosoma mansoni tyrosine kinase 0.0517 0.0483 0.1499
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0146 0.0015 0.0015
Schistosoma mansoni tyrosine kinase 0.0794 0.0831 0.2587
Schistosoma mansoni serine/threonine protein kinase 0.1043 0.1144 0.3567
Onchocerca volvulus 0.0879 0.0938 0.2809
Echinococcus granulosus mitogen activated protein kinase 3 0.0169 0.0045 0.0091
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0327 0.0244 0.0435
Plasmodium falciparum protein kinase 5 0.0871 0.0928 1
Schistosoma mansoni protein kinase 0.0236 0.0129 0.0393
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0351 0.0274 0.2921
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0032 0.0308
Trichomonas vaginalis CAMK family protein kinase 0.0352 0.0275 0.2908
Trypanosoma brucei protein kinase, putative 0.0862 0.0917 0.988
Echinococcus granulosus TGF-beta receptor type-1 0.0269 0.017 0.0485
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0139 0.0007 0.0038
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0236 0.0129 0.0358
Trichomonas vaginalis STE family protein kinase 0.0334 0.0252 0.2662
Entamoeba histolytica PH domain containing protein kinase, putative 0.0139 0.0007 0.0027
Brugia malayi hypothetical protein 0.0508 0.0471 0.0463
Plasmodium falciparum calcium-dependent protein kinase 2 0.0327 0.0244 0.2597
Brugia malayi Variant SH3 domain containing protein 0.0158 0.0031 0.0022
Onchocerca volvulus 0.0959 0.1038 0.3127
Loa Loa (eye worm) hypothetical protein 0.0744 0.0768 0.0768
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0542 0.0513 0.0949
Loa Loa (eye worm) AGC/PKN protein kinase 0.1015 0.1109 0.1109
Loa Loa (eye worm) hypothetical protein 0.0352 0.0275 0.0275
Schistosoma mansoni tyrosine kinase 0.0784 0.0818 0.2547
Loa Loa (eye worm) TK/FER protein kinase 0.0216 0.0104 0.0104
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0036
Echinococcus granulosus cGMP dependent protein kinase 1 0.0219 0.0108 0.0289
Echinococcus multilocularis raf serine:threonine protein kinase 0.0204 0.0089 0.014
Entamoeba histolytica PH domain containing protein kinase, putative 0.0841 0.089 0.3391
Echinococcus granulosus tyrosine protein kinase shark 0.1105 0.1222 0.3787
Entamoeba histolytica hypothetical protein 0.0139 0.0007 0.0027
Plasmodium vivax protein kinase Crk2 0.0871 0.0928 1
Schistosoma mansoni serine/threonine protein kinase 0.1015 0.1109 0.3456
Leishmania major protein kinase A catalytic subunit 0.0821 0.0864 0.9311
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0169 0.0045 0.0045
Trypanosoma brucei cdc2-related kinase 3 0.0871 0.0928 1
Brugia malayi Protein kinase domain containing protein 0.0784 0.0818 0.0811
Echinococcus granulosus serine:threonine protein kinase NLK 0.0176 0.0054 0.0121
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0589 0.0574 0.1751
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1367 0.1552 0.1552
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0429 0.0371 0.0363
Trypanosoma brucei casein kinase I, isoform 2 0.0351 0.0274 0.2921
Brugia malayi Protein kinase domain containing protein 0.2255 0.2667 0.2661
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0421 0.0362 0.0661
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0036
Entamoeba histolytica protein kinase, putative 0.0235 0.0128 0.0488
Echinococcus granulosus casein kinase ii subunit alpha 0.0185 0.0065 0.0155
Entamoeba histolytica protein kinase, putative 0.0167 0.0042 0.0159
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0334 0.0252 0.2691
Brugia malayi Cell division protein kinase 2 0.0176 0.0054 0.0045
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0821 0.0864 0.9311
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0327 0.0244 0.2597
Echinococcus multilocularis dual specificity 0.0765 0.0794 0.1484
Trypanosoma cruzi casein kinase, putative 0.0351 0.0274 0.2921
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.2219 0.2623 0.4972
Echinococcus granulosus serine:threonine protein kinase TAO1 0.07 0.0713 0.2188
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.1022 0.1117 0.1117
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0348 0.027 0.0798
Entamoeba histolytica casein kinase, putative 0.0351 0.0274 0.1043
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0862 0.0917 0.988
Trichomonas vaginalis CMGC family protein kinase 0.0169 0.0045 0.0437
Entamoeba histolytica serine/threonine protein kinase, putative 0.0136 0.0004 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Brugia malayi C1-like domain containing protein 0.0603 0.0591 0.0582
Schistosoma mansoni protein kinase 0.0234 0.0127 0.0385
Trichomonas vaginalis cAMP-dependent protein kinase catalytic subunit, putative 0.0139 0.0007 0.0036
Onchocerca volvulus 0.0879 0.0938 0.2809
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0348 0.027 0.0798
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0327 0.0244 0.0435
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0821 0.0864 0.9311
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0523 0.0489 0.0489
Loa Loa (eye worm) protein kinase domain-containing protein 0.0296 0.0205 0.0205
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0036
Giardia lamblia Kinase, AGC PKA 0.0821 0.0864 0.9209
Schistosoma mansoni tyrosine kinase 0.0421 0.0362 0.112
Echinococcus multilocularis epidermal growth factor receptor 0.0794 0.0831 0.1555
Leishmania major casein kinase II, putative 0.0185 0.0065 0.0662
Trichomonas vaginalis AGC family protein kinase 0.0176 0.0054 0.0538
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0405 0.0341 0.3651
Trichomonas vaginalis AGC family protein kinase 0.0176 0.0054 0.0538
Trichomonas vaginalis CAMK family protein kinase 0.041 0.0348 0.3681
Trichomonas vaginalis CMGC family protein kinase 0.0871 0.0928 0.9891
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Loa Loa (eye worm) CAMK protein kinase 0.0192 0.0074 0.0074
Echinococcus granulosus mitogen activated protein kinase 11 0.0506 0.0469 0.1424
Loa Loa (eye worm) AGC/NDR protein kinase 0.0348 0.027 0.027
Trypanosoma cruzi aurora B kinase, putative 0.0347 0.0269 0.2867
Entamoeba histolytica protein kinase, putative 0.0215 0.0103 0.0391
Echinococcus granulosus hypothetical protein 0.0744 0.0768 0.236
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0429 0.0371 0.3976
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Giardia lamblia Kinase, AGC AKT 0.0384 0.0316 0.3339
Trichomonas vaginalis AGC family protein kinase 0.0176 0.0054 0.0538
Brugia malayi Protein kinase domain containing protein 0.1552 0.1784 0.1777
Loa Loa (eye worm) hypothetical protein 0.0256 0.0154 0.0154
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0234 0.0127 0.0212
Trichomonas vaginalis CAMK family protein kinase 0.0222 0.0111 0.1147
Trypanosoma cruzi p21-activated kinase 3, putative 0.014 0.0009 0.0053
Schistosoma mansoni protein kinase 0.0176 0.0054 0.0157
Brugia malayi RhoGAP domain containing protein 0.0189 0.007 0.0062
Schistosoma mansoni serine/threonine protein kinase 0.0222 0.0111 0.0335
Schistosoma mansoni ste20-related kinase 0.0836 0.0883 0.275
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.07 0.0713 0.1329
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0139 0.0007 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.0387 0.0319 0.0986
Trypanosoma brucei Casein kinase II 0.0185 0.0065 0.0662
Echinococcus multilocularis tyrosine protein kinase Srms 0.0364 0.029 0.0523
Leishmania major protein kinase, putative 0.0327 0.0244 0.2597
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0242 0.0136 0.023
Echinococcus multilocularis myosin iiia 0.0334 0.0252 0.0452
Brugia malayi STE20-like kinase MST 0.1051 0.1154 0.1146
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0327 0.0244 0.0716
Echinococcus granulosus serine:threonine kinase SAD 1 0.0222 0.0111 0.0299
Loa Loa (eye worm) hypothetical protein 0.0229 0.012 0.012
Schistosoma mansoni serine/threonine protein kinase 0.0327 0.0244 0.075
Toxoplasma gondii histone kinase SNF1, putative 0.0222 0.0111 0.1159
Loa Loa (eye worm) thyroid receptor interactor 0.0431 0.0374 0.0374
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0399 0.0334 0.0998
Trypanosoma cruzi cdc2-related kinase 3 0.0871 0.0928 1
Trichomonas vaginalis CMGC family protein kinase 0.0169 0.0045 0.0437
Onchocerca volvulus Serine\/threonine kinase homolog 0.0248 0.0144 0.0286
Entamoeba histolytica cell division protein kinase 2, putative 0.0929 0.1 0.3812
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.0108 0.0325
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0223 0.0113 0.1182
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1552 0.1784 0.3371
Giardia lamblia Kinase, CMGC CK2 0.0185 0.0065 0.0654
Echinococcus multilocularis tyrosine protein kinase ABL1 0.042 0.0361 0.0658
Loa Loa (eye worm) IKK protein kinase 0.205 0.241 0.241
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.2255 0.2667 0.5056
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0234 0.0127 0.1333
Brugia malayi Protein kinase domain containing protein 0.0782 0.0815 0.0807
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0863 0.0917 0.9883
Echinococcus multilocularis serine:threonine protein kinase 0.0159 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0515 0.048 0.048
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0032 0.0308
Brugia malayi Protein kinase domain containing protein 0.0677 0.0684 0.0676
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0862 0.0917 0.988
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Trichomonas vaginalis CAMK family protein kinase 0.0222 0.0111 0.1147
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0517 0.0483 0.0891
Trypanosoma cruzi polo-like protein kinase, putative 0.0352 0.0275 0.294
Loa Loa (eye worm) hypothetical protein 0.0395 0.033 0.033
Plasmodium falciparum casein kinase 1 0.0351 0.0274 0.2921
Schistosoma mansoni serine/threonine kinase 0.0839 0.0887 0.2763
Onchocerca volvulus 0.0232 0.0124 0.0223
Trichomonas vaginalis AGC family protein kinase 0.0368 0.0295 0.3118
Echinococcus granulosus NDR protein kinase 0.0348 0.027 0.0798
Schistosoma mansoni protein kinase 0.1349 0.1529 0.4768
Loa Loa (eye worm) hypothetical protein 0.0646 0.0645 0.0645
Echinococcus multilocularis cyclin dependent kinase 7 0.0678 0.0684 0.1276
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0234 0.0127 0.035
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0421 0.0362 0.0661
Echinococcus multilocularis ephrin type A receptor 4 A 0.0178 0.0057 0.0079
Echinococcus granulosus growth factor receptor bound protein 2 0.0163 0.0038 0.007
Echinococcus multilocularis casein kinase ii subunit alpha 0.0185 0.0065 0.0094
Loa Loa (eye worm) hypothetical protein 0.024 0.0134 0.0134
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0007 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Leishmania major protein kinase, putative 0.0863 0.0917 0.9883
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0229 0.012 0.02
Loa Loa (eye worm) CAMK/PIM protein kinase 0.2255 0.2667 0.2667
Brugia malayi Protein kinase domain containing protein 0.0159 0.0032 0.0023
Echinococcus multilocularis CDC7 cell division cycle 7 0.0879 0.0938 0.1759
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0236 0.0129 0.0358
Trichomonas vaginalis CMGC family protein kinase 0.0169 0.0045 0.0437
Echinococcus granulosus activated cdc42 kinase 1 0.0462 0.0413 0.1248
Schistosoma mansoni serine/threonine protein kinase 0.0176 0.0054 0.0157
Echinococcus multilocularis serine:threonine protein kinase NLK 0.0176 0.0054 0.0073
Toxoplasma gondii AGC kinase 0.0821 0.0864 0.9311
Echinococcus granulosus cyclin dependent kinase 9 0.0446 0.0394 0.1187
Echinococcus granulosus tyrosine protein kinase Lyn 0.054 0.0512 0.1557
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0438 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0222 0.0111 0.0111
Brugia malayi phosphoinositide-dependent protein kinase I 0.0167 0.0042 0.0033
Brugia malayi hypothetical protein 0.027 0.0171 0.0163
Echinococcus multilocularis Immunoglobulin 0.0256 0.0154 0.0265
Schistosoma mansoni tyrosine kinase 0.0474 0.0428 0.1328
Brugia malayi Fes/CIP4 homology domain containing protein 0.0431 0.0374 0.0366
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0222 0.0111 0.0182
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0871 0.0928 1
Echinococcus granulosus epidermal growth factor receptor 0.0794 0.0831 0.256
Schistosoma mansoni serine/threonine protein kinase 0.0204 0.0089 0.0266
Schistosoma mansoni protein kinase 0.0429 0.0371 0.1149
Echinococcus multilocularis casein kinase I delta 0.0351 0.0274 0.0492
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0247 0.0142 0.0142
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0224 0.0114 0.0114
Echinococcus granulosus titin 0.0192 0.0074 0.0182
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0139 0.0007 0.0038
Schistosoma mansoni growth factor receptor-bound protein 0.0163 0.0038 0.0106
Giardia lamblia Kinase, CAMK CAMKL 0.0279 0.0183 0.192
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0249 0.0146 0.1518
Trichomonas vaginalis AGC family protein kinase 0.0347 0.0269 0.2836
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.047 0.0423 0.0423
Loa Loa (eye worm) casein kinase 0.0177 0.0055 0.0055
Trypanosoma cruzi casein kinase, putative 0.0351 0.0274 0.2921
Schistosoma mansoni serine/threonine protein kinase 0.0678 0.0684 0.2129
Echinococcus multilocularis protein kinase c epsilon type 0.0438 0.0383 0.07
Entamoeba histolytica cell division protein kinase 2, putative 0.0871 0.0928 0.3537
Trichomonas vaginalis CMGC family protein kinase 0.0185 0.0065 0.0654
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0508 0.0471 0.0869
Trypanosoma cruzi casein kinase, putative 0.0351 0.0274 0.2921
Schistosoma mansoni protein kinase 0.0804 0.0843 0.2624
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0871 0.0928 0.0928
Entamoeba histolytica protein kinase, putative 0.047 0.0423 0.1611
Echinococcus granulosus protein kinase 0.0804 0.0843 0.2597
Trichomonas vaginalis STE family protein kinase 0.0429 0.0371 0.3933
Loa Loa (eye worm) hypothetical protein 0.0426 0.0368 0.0368
Brugia malayi Protein kinase domain containing protein 0.0879 0.0938 0.093
Loa Loa (eye worm) hypothetical protein 0.1219 0.1365 0.1365
Brugia malayi intracellular kinase 0.0862 0.0917 0.0909
Schistosoma mansoni rap gtpase-activating protein 0.0508 0.0471 0.1463
Entamoeba histolytica serine/threonine protein kinase, putative 0.0222 0.0111 0.0422
Schistosoma mansoni serine/threonine protein kinase 0.0352 0.0275 0.085
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.0054 0.0538
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0815 0.0856 0.2639
Trichomonas vaginalis serine/threonine kinase, putative 0.0176 0.0054 0.0538
Toxoplasma gondii casein kinase I 0.0351 0.0274 0.2921
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0189 0.007 0.0208

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 9.4662 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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