Detailed information for compound 1362055

Basic information

Technical information
  • TDR Targets ID: 1362055
  • Name: 7-chloro-N-(2-dimethylamino-2-furan-2-ylethyl )-3-methyl-1-benzofuran-2-carboxamide
  • MW: 346.808 | Formula: C18H19ClN2O3
  • H donors: 1 H acceptors: 1 LogP: 3.6 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1oc2c(c1C)cccc2Cl)NCC(c1ccco1)N(C)C
  • InChi: 1S/C18H19ClN2O3/c1-11-12-6-4-7-13(19)17(12)24-16(11)18(22)20-10-14(21(2)3)15-8-5-9-23-15/h4-9,14H,10H2,1-3H3,(H,20,22)
  • InChiKey: JMOGGVIWCLTQHU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 7-chloro-N-[2-dimethylamino-2-(2-furyl)ethyl]-3-methyl-benzofuran-2-carboxamide
  • 7-chloro-N-[2-dimethylamino-2-(2-furyl)ethyl]-3-methyl-2-benzofurancarboxamide
  • 7-chloro-N-(2-dimethylamino-2-furan-2-yl-ethyl)-3-methyl-1-benzofuran-2-carboxamide
  • T5443557

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus transient receptor potential cation channel, subfamily C, member 4 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens Ras and Rab interactor 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus TRP transient receptor potential channel Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus granulosus transient receptor potential gamma protein Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma japonicum Short transient receptor potential channel 5, putative Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus multilocularis transient receptor potential ion channel A Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma japonicum ko:K05328 transient receptor potential cation channel, subfamily C,, putative Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus multilocularis transient receptor potential gamma protein Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma japonicum Short transient receptor potential channel 5, putative Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma mansoni transient receptor potential channel 4 Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma mansoni transient receptor potential channel Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma japonicum ko:K05328 transient receptor potential cation channel, subfamily C,, putative Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma japonicum Transient receptor potential-gamma protein, putative Get druggable targets OG5_128782 All targets in OG5_128782
Brugia malayi Transient-receptor-potential like protein Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus multilocularis TRP (transient receptor potential) channel Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus granulosus transient receptor potential ion channel A Get druggable targets OG5_128782 All targets in OG5_128782
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis short transient receptor potential channel 6 transient receptor potential cation channel, subfamily C, member 4 890 aa 799 aa 31.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase Srms 0.0218 0.0193 0.0483
Schistosoma mansoni serine/threonine protein kinase 0.0243 0.0231 0.0705
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Schistosoma mansoni protein kinase 0.0155 0.0099 0.0296
Echinococcus granulosus neuroglian 0.0136 0.0071 0.0179
Loa Loa (eye worm) hypothetical protein 0.0325 0.0353 0.0353
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0147 0.1238
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0139 0.0075 0.0075
Echinococcus granulosus tyrosine protein kinase Btk29A 0.044 0.0525 0.1599
Loa Loa (eye worm) hypothetical protein 0.0631 0.0811 0.0811
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0216 0.019 0.019
Echinococcus granulosus homeodomain interacting protein kinase 3 0.2061 0.2953 0.919
Echinococcus granulosus serine:threonine protein kinase 3 0.0543 0.068 0.2084
Giardia lamblia Kinase, STE STE20 0.0192 0.0155 0.125
Trichomonas vaginalis AGC family protein kinase 0.0202 0.017 0.1451
Echinococcus multilocularis tyrosine kinase 0.0128 0.0058 0.0121
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0196 0.016 0.1493
Entamoeba histolytica protein kinase 2, putative 0.0214 0.0187 0.0578
Echinococcus multilocularis cyclin dependent kinase 9 0.0323 0.035 0.0905
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0718 0.0942 0.0942
Leishmania major protein kinase, putative 0.0202 0.017 0.1706
Schistosoma mansoni tyrosine kinase 0.0102 0.002 0.0048
Trypanosoma brucei protein kinase, putative 0.0155 0.0099 0.0862
Schistosoma mansoni vam6/vps39 related 0.0325 0.0353 0.1087
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0257 0.0251 0.0637
Brugia malayi SRC-1 0.0257 0.0251 0.0251
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0137 0.0071 0.0156
Trypanosoma brucei casein kinase I, isoform 2 0.0242 0.0229 0.2216
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0155 0.0099 0.0268
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0187 0.0147 0.0359
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0071 0.0517
Trypanosoma cruzi casein kinase, putative 0.0242 0.0229 0.2216
Echinococcus granulosus casein kinase i 0.0242 0.0229 0.0673
Trichomonas vaginalis CAMK family protein kinase 0.0339 0.0374 0.3391
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0202 0.017 0.052
Trichomonas vaginalis AGC family protein kinase 0.0202 0.017 0.1451
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.033 0.0361 0.0933
Echinococcus granulosus casein kinase I delta 0.0242 0.0229 0.0673
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0187 0.0147 0.0418
Brugia malayi casein kinase I 0.0242 0.0229 0.0229
Brugia malayi Furin-like cysteine rich region family protein 0.0647 0.0836 0.0836
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Loa Loa (eye worm) AUR protein kinase 0.0202 0.017 0.017
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0202 0.0169 0.0417
Entamoeba histolytica protein kinase, putative 0.0165 0.0113 0.0327
Echinococcus multilocularis activin receptor type 0.0155 0.0099 0.0231
Trypanosoma cruzi casein kinase, putative 0.0242 0.0229 0.2216
Loa Loa (eye worm) hypothetical protein 0.0565 0.0712 0.0712
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0155 0.0099 0.0231
Schistosoma mansoni protein kinase 0.0755 0.0997 0.3094
Loa Loa (eye worm) TK protein kinase 0.0218 0.0193 0.0193
Echinococcus granulosus casein kinase I alpha 0.0242 0.0229 0.0673
Trichomonas vaginalis CAMK family protein kinase 0.033 0.0361 0.3271
Giardia lamblia Kinase, CMGC CDK 0.0718 0.0942 0.8785
Brugia malayi Protein kinase c protein 2 0.0187 0.0147 0.0147
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0675 0.0878 0.9017
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0652 0.0843 0.8647
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.0099 0.028
Trichomonas vaginalis CAMK family protein kinase 0.0145 0.0084 0.0633
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0139 0.0075 0.0606
Plasmodium falciparum casein kinase 2, alpha subunit 0.0156 0.01 0.0869
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0261 0.0258 0.0657
Schistosoma mansoni serine/threonine protein kinase 0.2234 0.3212 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0139 0.0075 0.0606
Loa Loa (eye worm) hypothetical protein 0.0142 0.0079 0.0079
Trichomonas vaginalis CAMK family protein kinase 0.0145 0.0084 0.0633
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0127 0.0056 0.0134
Entamoeba histolytica PH domain containing protein kinase, putative 0.0689 0.0898 0.3001
Trichomonas vaginalis AGC family protein kinase 0.0281 0.0287 0.2569
Echinococcus granulosus Protein kinase C brain isozyme 0.0347 0.0386 0.1164
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0126 0.0055 0.013
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0187 0.0147 0.0147
Echinococcus multilocularis nervana 2 0.0127 0.0056 0.0115
Brugia malayi Protein kinase domain containing protein 0.0251 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0193 0.0156 0.0156
Schistosoma mansoni tyrosine kinase 0.0132 0.0065 0.0188
Trichomonas vaginalis CAMK family protein kinase 0.0145 0.0084 0.0633
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.056 0.0705 0.1857
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0665 0.0862 0.0862
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0118 0.0043 0.0121
Schistosoma mansoni serine/threonine protein kinase 0.0457 0.0551 0.1704
Echinococcus multilocularis dual specificity 0.0196 0.016 0.0392
Echinococcus granulosus defective proboscis extension response 0.0117 0.0042 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0145 0.0084 0.0633
Plasmodium vivax serine/threonine protein kinase, putative 0.0138 0.0074 0.0596
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0325 0.0353 0.3519
Echinococcus granulosus cyclin dependent kinase 9 0.0323 0.035 0.1053
Trichomonas vaginalis AGC family protein kinase 0.0267 0.0267 0.2378
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Leishmania major protein kinase A catalytic subunit 0.0675 0.0878 0.903
Onchocerca volvulus 0.0803 0.1069 0.3313
Entamoeba histolytica protein kinase , putative 0.0202 0.017 0.052
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0675 0.0878 0.2703
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0412 0.0483 0.1263
Echinococcus granulosus cyclin dependent kinase 0.0718 0.0942 0.2902
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0257 0.0251 0.0637
Entamoeba histolytica serine/threonine protein kinase, putative 0.0105 0.0024 0.0025
Trypanosoma brucei SNF1-related protein kinases, putative 0.0145 0.0084 0.0697
Trichomonas vaginalis CAMK family protein kinase 0.0145 0.0084 0.0633
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0325 0.0353 0.1087
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0244 0.0231 0.0231
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0139 0.0075 0.0606
Giardia lamblia Kinase, AGC AKT 0.0172 0.0124 0.0954
Echinococcus granulosus NDR protein kinase 0.0246 0.0236 0.0695
Loa Loa (eye worm) hypothetical protein 0.0675 0.0878 0.0878
Brugia malayi Protein kinase domain containing protein 0.0668 0.0867 0.0867
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0156 0.01 0.0869
Echinococcus granulosus Immunoglobulin 0.0117 0.0042 0.0089
Loa Loa (eye worm) TK/FER protein kinase 0.0128 0.0058 0.0058
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0218 0.0193 0.0483
Echinococcus granulosus expressed protein 0.0138 0.0074 0.0189
Echinococcus multilocularis dual specificity protein kinase clk2 0.0652 0.0843 0.2227
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0652 0.0843 0.8647
Trichomonas vaginalis AGC family protein kinase 0.0386 0.0445 0.4074
Echinococcus multilocularis serine:threonine protein kinase 3 0.0543 0.068 0.1791
Echinococcus granulosus tyrosine protein kinase Fyn 0.0257 0.0251 0.0742
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Echinococcus multilocularis protein kinase c epsilon type 0.0306 0.0325 0.0837
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0271 0.0273 0.0697
Schistosoma mansoni serine/threonine protein kinase 0.0242 0.0229 0.0699
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0339 0.0374 0.1126
Trichomonas vaginalis AGC family protein kinase 0.0386 0.0445 0.4074
Entamoeba histolytica protein kinase, putative 0.0386 0.0445 0.1459
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0048 0.0298
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0028 0.0108
Brugia malayi Protein kinase domain containing protein 0.0311 0.0332 0.0332
Schistosoma mansoni serine/threonine protein kinase 0.0246 0.0236 0.0721
Plasmodium vivax calcium-dependent protein kinase, putative 0.0187 0.0147 0.1363
Schistosoma mansoni tyrosine kinase 0.0166 0.0116 0.0347
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0145 0.0084 0.0697
Echinococcus multilocularis ephrin type A receptor 4 A 0.0134 0.0067 0.0144
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Giardia lamblia Kinase, CMGC SRPK 0.0138 0.0074 0.0476
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0191 0.0153 0.0374
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Echinococcus granulosus dual specificity 0.0196 0.016 0.0457
Echinococcus granulosus tyrosine kinase 0.0218 0.0193 0.0562
Plasmodium vivax tyrosine kinase-like protein, putative 0.0136 0.0071 0.0562
Schistosoma mansoni serine/threonine protein kinase 0.0145 0.0084 0.0246
Plasmodium vivax serine/threonine kinase-1, putative 0.0652 0.0843 0.8647
Leishmania major protein kinase, putative 0.01 0.0017 0.0129
Loa Loa (eye worm) hypothetical protein 0.0129 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0122 0.0049 0.0049
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0257 0.0251 0.0637
Echinococcus multilocularis casein kinase I alpha 0.0242 0.0229 0.0578
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0237 0.0221 0.0221
Echinococcus granulosus mitogen activated protein kinase 15 0.0128 0.0059 0.0142
Trichomonas vaginalis STE family protein kinase 0.0173 0.0126 0.1039
Loa Loa (eye worm) haspin protein kinase 0.0128 0.0059 0.0059
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0139 0.0075 0.0727
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0675 0.0878 0.9017
Brugia malayi Protein kinase domain containing protein 0.0803 0.1069 0.1069
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.211 0.3026 0.8093
Trypanosoma cruzi casein kinase, putative 0.0242 0.0229 0.2216
Trichomonas vaginalis AGC family protein kinase 0.0178 0.0133 0.1107
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0675 0.0878 0.2703
Loa Loa (eye worm) AGC/PKA protein kinase 0.0675 0.0878 0.0878
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0487 0.0595 0.1819
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0267 0.0267 0.0267
Echinococcus multilocularis 0.0178 0.0133 0.0321
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Trichomonas vaginalis AGC family protein kinase 0.0386 0.0445 0.4074
Loa Loa (eye worm) TK/INSR protein kinase 0.048 0.0586 0.0586
Trichomonas vaginalis AGC family protein kinase 0.0128 0.0059 0.0399
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0652 0.0843 0.0843
Giardia lamblia Kinase, CMGC CDK 0.0718 0.0942 0.8785
Entamoeba histolytica cell division protein kinase 2, putative 0.0759 0.1004 0.336
Plasmodium falciparum protein kinase 5 0.0718 0.0942 0.9683
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0718 0.0942 0.0942
Loa Loa (eye worm) hypothetical protein 0.0187 0.0147 0.0147
Brugia malayi Immunoglobulin I-set domain containing protein 0.0112 0.0035 0.0035
Giardia lamblia Kinase, CMGC GSK 0.0738 0.0972 0.9075
Loa Loa (eye worm) hypothetical protein 0.0123 0.0051 0.0051
Giardia lamblia Kinase, STE STE20 0.0173 0.0126 0.0977
Trichomonas vaginalis AGC family protein kinase 0.0386 0.0445 0.4074
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0138 0.0074 0.0596
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0738 0.0972 0.0972
Schistosoma mansoni kinase 0.0349 0.0389 0.12
Loa Loa (eye worm) hypothetical protein 0.0325 0.0353 0.0353
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Schistosoma mansoni tyrosine kinase 0.0365 0.0414 0.1276
Loa Loa (eye worm) AGC/AKT protein kinase 0.0386 0.0445 0.0445
Echinococcus multilocularis mitogen activated protein kinase 14 0.0216 0.019 0.0475
Brugia malayi Stress-activated protein kinase jnk-1 0.0324 0.0352 0.0352
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0155 0.0098 0.085
Brugia malayi serine/threonine protein kinase 6 0.0202 0.017 0.017
Brugia malayi putative serine/threonine kinase SADA gamma 0.0145 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0273 0.0276 0.0276
Brugia malayi hypothetical protein 0.0128 0.0058 0.0058
Echinococcus granulosus insulin receptor 0.048 0.0586 0.179
Trichomonas vaginalis AGC family protein kinase 0.0128 0.0059 0.0399
Trichomonas vaginalis protein kinase atmrk1, putative 0.0128 0.0059 0.0399
Entamoeba histolytica serine/threonine protein kinase, putative 0.0145 0.0084 0.0227
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0028 0.0108
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0864 0.1161 0.3588
Echinococcus multilocularis casein kinase I alpha 0.0242 0.0229 0.0578
Trichomonas vaginalis CAMK family protein kinase 0.0183 0.014 0.1172
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0196 0.016 0.1493
Echinococcus granulosus cGMP dependent protein kinase 0.0191 0.0153 0.0436
Brugia malayi Variant SH3 domain containing protein 0.0098 0.0013 0.0013
Leishmania major protein kinase, putative 0.0105 0.0024 0.0204
Plasmodium falciparum protein serine/threonine kinase-1 0.0652 0.0843 0.8647
Entamoeba histolytica protein kinase, putative 0.0386 0.0445 0.1459
Loa Loa (eye worm) TK protein kinase 0.0158 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0668 0.0867 0.0867
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0412 0.0483 0.1469
Schistosoma mansoni serine/threonine protein kinase 0.0272 0.0273 0.0839
Entamoeba histolytica protein kinase, putative 0.0137 0.0071 0.0185
Giardia lamblia Kinase, CAMK CAMKL 0.0186 0.0145 0.1162
Brugia malayi Protein kinase domain containing protein 0.0129 0.0059 0.0059
Schistosoma mansoni serine/threonine protein kinase 0.0191 0.0153 0.0463
Loa Loa (eye worm) AUR protein kinase 0.0202 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0329 0.036 0.036
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.6765 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0024 0.0069
Schistosoma mansoni tyrosine kinase 0.048 0.0586 0.1813
Leishmania major serine/threonine kinase-like protein, putative 0.0128 0.0059 0.0563
Giardia lamblia Kinase, CAMK CAMKL 0.0128 0.0059 0.0333
Echinococcus granulosus serine/threonine protein kinase 0.0227 0.0207 0.0604
Schistosoma mansoni hypothetical protein 0.0156 0.01 0.0299
Giardia lamblia Kinase, CDC7 0.0803 0.1069 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0131 0.0063 0.0063
Leishmania major casein kinase, putative 0.0242 0.0229 0.2317
Trichomonas vaginalis CAMK family protein kinase 0.0145 0.0084 0.0633
Schistosoma mansoni tyrosine kinase 0.0434 0.0516 0.1595
Toxoplasma gondii NEK kinase 0.0105 0.0024 0.0076
Entamoeba histolytica hypothetical protein 0.036 0.0406 0.1326
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0675 0.0878 0.9017
Brugia malayi casein kinase 1, delta 0.0242 0.0229 0.0229
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Brugia malayi Protein kinase domain containing protein 0.0652 0.0843 0.0843
Echinococcus multilocularis mitogen activated protein kinase 11 0.0216 0.019 0.0475
Brugia malayi Immunoglobulin I-set domain containing protein 0.0291 0.0302 0.0302
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0601 0.0766 0.2022
Schistosoma mansoni ste20-related kinase 0.0438 0.0522 0.1615
Echinococcus granulosus raf serine:threonine protein kinase 0.0127 0.0056 0.0134
Plasmodium falciparum serine/threonine protein kinase 0.0138 0.0074 0.0596
Trypanosoma cruzi Protein kinase B 0.0227 0.0207 0.1986
Schistosoma mansoni serine/threonine protein kinase 0.0354 0.0397 0.1224
Schistosoma mansoni serine/threonine protein kinase 0.0306 0.0325 0.0999
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0048 0.0298
Schistosoma mansoni vav2 0.0131 0.0063 0.0184
Brugia malayi Protein kinase domain containing protein 0.0386 0.0445 0.0445
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0246 0.0236 0.0695
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0128 0.0058 0.0141
Echinococcus granulosus mitogen activated protein kinase 14 0.0216 0.019 0.0553
Loa Loa (eye worm) CAMK protein kinase 0.0112 0.0035 0.0035
Echinococcus granulosus tyrosine kinase 0.0128 0.0058 0.0141
Loa Loa (eye worm) TK/EGFR protein kinase 0.0647 0.0836 0.0836
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0257 0.0251 0.0637
Trypanosoma brucei aurora B kinase 0.0202 0.017 0.1598
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0193 0.0155 0.1448
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0214 0.0187 0.0541
Brugia malayi Protein kinase domain containing protein 0.0267 0.0267 0.0267
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0864 0.1161 0.1161
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0192 0.0155 0.1443
Trypanosoma cruzi cdc2-related kinase 1 0.0718 0.0942 0.9683
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0324 0.0352 0.0352
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.036 0.0406 0.0406
Entamoeba histolytica protein kinase domain containing protein 0.0196 0.016 0.0486
Trichomonas vaginalis CMGC family protein kinase 0.0738 0.0972 0.9081
Leishmania major serine/threonine-protein kinase a, putative 0.01 0.0017 0.0129
Giardia lamblia Kinase, CK1 Casein kinase 0.0242 0.0229 0.1957
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0172 0.0124 0.0124
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0112 0.0035 0.0035
Plasmodium vivax serine/threonine-protein kinase Nek1, putative 0.0105 0.0024 0.0076
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Giardia lamblia Kinase, CMGC CLK 0.0652 0.0843 0.7837
Echinococcus granulosus dual specificity 0.0196 0.016 0.0457
Loa Loa (eye worm) hypothetical protein 0.0271 0.0272 0.0272
Brugia malayi Protein kinase domain containing protein 0.211 0.3026 0.3026
Echinococcus granulosus cGMP dependent protein kinase 1 0.0191 0.0153 0.0436
Loa Loa (eye worm) hypothetical protein 0.0098 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0473 0.0574 0.0574
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0434 0.0516 0.1572
Brugia malayi hypothetical protein 0.0325 0.0353 0.0353
Plasmodium falciparum calcium-dependent protein kinase 3 0.0187 0.0147 0.1363
Trichomonas vaginalis CAMK family protein kinase 0.0145 0.0084 0.0633
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.033 0.0361 0.0361
Brugia malayi Temporarily assigned gene name protein 59 0.0132 0.0064 0.0064
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0738 0.0972 0.2575
Echinococcus granulosus roundabout 2 0.0157 0.0102 0.0278
Brugia malayi phosphoinositide-dependent protein kinase I 0.0137 0.0071 0.0071
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0145 0.0084 0.0697
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0827 0.1105 0.3414
Echinococcus granulosus cyclin dependent kinase 5 0.0718 0.0942 0.2902
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0117 0.0042 0.0117
Loa Loa (eye worm) hypothetical protein 0.0193 0.0156 0.0156
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0271 0.0273 0.0811
Schistosoma mansoni nephrin 0.0143 0.008 0.0235
Echinococcus granulosus calcium activated potassium channel 0.0247 0.0237 0.0698
Loa Loa (eye worm) hypothetical protein 0.0147 0.0087 0.0087
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0738 0.0972 1
Leishmania major protein kinase, putative 0.0192 0.0155 0.1553
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0139 0.0075 0.0606
Toxoplasma gondii CMGC kinase, CK2 family 0.0156 0.01 0.0869
Trichomonas vaginalis CMGC family protein kinase 0.0196 0.016 0.1356
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0246 0.0236 0.0597
Brugia malayi Variant SH3 domain containing protein 0.0098 0.0013 0.0013
Echinococcus multilocularis dual specificity 0.0196 0.016 0.0392
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0242 0.0229 0.2216
Echinococcus granulosus serine:threonine protein kinase N2 0.0397 0.0461 0.1399
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Onchocerca volvulus 0.0142 0.0079 0.0228
Echinococcus granulosus dual specificity protein kinase clk2 0.0652 0.0843 0.2592
Loa Loa (eye worm) hypothetical protein 0.0151 0.0093 0.0093
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0075 0.055
Schistosoma mansoni growth factor receptor-bound protein 0.01 0.0017 0.0038
Schistosoma mansoni protein kinase 0.0864 0.1161 0.3606
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0173 0.0126 0.0303
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0246 0.0236 0.0597
Echinococcus multilocularis raf serine:threonine protein kinase 0.0127 0.0056 0.0115
Echinococcus granulosus epidermal growth factor receptor 0.0434 0.0516 0.1572
Echinococcus granulosus nervana 2 0.0127 0.0056 0.0134
Loa Loa (eye worm) hypothetical protein 0.0271 0.0272 0.0272
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0128 0.0059 0.0439
Entamoeba histolytica hypothetical protein 0.0389 0.0449 0.1473
Loa Loa (eye worm) SRC-1 0.0257 0.0251 0.0251
Trichomonas vaginalis STE family protein kinase 0.0151 0.0093 0.0722
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0244 0.0231 0.0585
Trichomonas vaginalis CMGC family protein kinase 0.0803 0.1069 1
Loa Loa (eye worm) hypothetical protein 0.0213 0.0186 0.0186
Toxoplasma gondii AGC kinase 0.0373 0.0425 0.4277
Brugia malayi protein-tyrosine kinase 0.0218 0.0193 0.0193
Schistosoma mansoni serine/threonine protein kinase 0.0652 0.0843 0.2613
Loa Loa (eye worm) hypothetical protein 0.015 0.009 0.009
Schistosoma mansoni serine/threonine protein kinase 0.0246 0.0236 0.0721
Entamoeba histolytica casein kinase 1, putative 0.0242 0.0229 0.0721
Giardia lamblia Kinase, CMGC MAPK 0.0139 0.0075 0.0485
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0331 0.0363 0.0938
Loa Loa (eye worm) hypothetical protein 0.0389 0.0449 0.0449
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0675 0.0878 0.2322
Onchocerca volvulus 0.0128 0.0058 0.0163
Trypanosoma brucei polo-like protein kinase 0.033 0.0361 0.3602
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0028 0.0108
Trypanosoma brucei NIMA-related protein kinase 0.0105 0.0024 0.0076
Schistosoma mansoni serine/threonine protein kinase 0.0675 0.0878 0.2723
Echinococcus granulosus cyclin dependent kinase 7 0.049 0.06 0.1834
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.211 0.3026 0.942
Loa Loa (eye worm) TK/EPH protein kinase 0.0152 0.0094 0.0094
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0257 0.0251 0.0637
Brugia malayi probable protein kinase 0.0914 0.1236 0.1236
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0109 0.003 0.003
Schistosoma mansoni nck2/grb4 0.0098 0.0013 0.0028
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0187 0.0147 0.1363
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0166 0.0116 0.0347
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0285 0.0293 0.0874
Loa Loa (eye worm) AUR protein kinase 0.0202 0.017 0.017
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0145 0.0084 0.0817
Entamoeba histolytica protein kinase domain containing protein 0.0128 0.0059 0.0143
Brugia malayi Protein kinase domain containing protein 0.0128 0.0058 0.0058
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.052 0.0645 0.1697
Onchocerca volvulus 0.0271 0.0272 0.083
Brugia malayi Protein kinase domain containing protein 0.0215 0.0189 0.0189
Trypanosoma brucei Casein kinase II 0.0156 0.01 0.0869
Schistosoma mansoni serine/threonine protein kinase 0.0718 0.0942 0.2922
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0138 0.0074 0.0596
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0173 0.0126 0.0303
Echinococcus granulosus protein kinase c epsilon type 0.0306 0.0325 0.0974
Echinococcus granulosus fibroblast growth factor receptor 4 0.0271 0.0273 0.0811
Echinococcus multilocularis mitogen activated protein kinase 0.0139 0.0075 0.0165
Echinococcus granulosus titin 0.0112 0.0035 0.0067
Entamoeba histolytica protein kinase, putative 0.0187 0.0147 0.0443
Schistosoma mansoni serine/threonine protein kinase 0.0347 0.0386 0.1189
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0281 0.0287 0.0735
Loa Loa (eye worm) protein kinase domain-containing protein 0.0272 0.0273 0.0273
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0048 0.0298
Echinococcus granulosus protein kinase 0.0589 0.0749 0.23
Schistosoma mansoni transient receptor potential channel 0.0117 0.0042 0.0117
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0285 0.0293 0.0751
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Trypanosoma cruzi cdc2-related kinase 3 0.0718 0.0942 0.9683
Loa Loa (eye worm) hypothetical protein 0.0156 0.01 0.01
Loa Loa (eye worm) CAMK/PIM protein kinase 0.211 0.3026 0.3026
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0028 0.0108
Brugia malayi hypothetical protein 0.0123 0.0051 0.0051
Plasmodium falciparum serine/threonine protein kinase KIN 0.0145 0.0084 0.0697
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0675 0.0878 0.9017
Trichomonas vaginalis CMGC family protein kinase 0.0156 0.01 0.0789
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0109 0.003 0.003
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0543 0.068 0.068
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0121 0.0048 0.0298
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0221 0.0198 0.0577
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0127 0.0056 0.0115
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0139 0.0075 0.0727
Trichomonas vaginalis CK1 family protein kinase 0.0242 0.0229 0.2012
Brugia malayi Protein kinase domain containing protein 0.0668 0.0867 0.0867
Onchocerca volvulus 0.0803 0.1069 0.3313
Entamoeba histolytica serine/threonine protein kinase, putative 0.033 0.0361 0.1172
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0675 0.0878 0.9017
Schistosoma mansoni serine/threonine protein kinase 0.0285 0.0293 0.0899
Schistosoma mansoni serine/threonine kinase 0.0536 0.0669 0.2073
Loa Loa (eye worm) thyroid receptor interactor 0.0262 0.0259 0.0259
Trichomonas vaginalis AGC family protein kinase 0.0267 0.0267 0.2378
Onchocerca volvulus 0.0738 0.0972 0.3012
Schistosoma mansoni serine/threonine protein kinase 0.054 0.0675 0.2089
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Onchocerca volvulus Serine\/threonine kinase homolog 0.033 0.0361 0.1106
Entamoeba histolytica PH domain containing protein kinase, putative 0.0227 0.0207 0.0646
Echinococcus multilocularis cyclin dependent kinase 5 0.0718 0.0942 0.2493
Echinococcus multilocularis casein kinase I gamma 0.0272 0.0273 0.0698
Echinococcus multilocularis rac serine:threonine kinase 0.0227 0.0207 0.0519
Schistosoma mansoni atypical protein kinase C 0.0396 0.046 0.1419
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0128 0.0059 0.0439
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0098 0.0013 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0048 0.0298
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0126 0.0055 0.0112
Entamoeba histolytica protein kinase domain containing protein 0.036 0.0406 0.1326
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0588 0.0748 0.1972
Trypanosoma cruzi Serine/threonine-protein kinase NEK11, putative 0.0105 0.0024 0.0076
Echinococcus multilocularis c src tyrosine kinase 0.0166 0.0116 0.0275
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0098 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0273 0.0276 0.0276
Brugia malayi cyclin-dependent kinase 7 homolog 0.0531 0.0662 0.0662
Loa Loa (eye worm) hypothetical protein 0.0099 0.0015 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Echinococcus multilocularis twitchin 0.0106 0.0026 0.0033
Schistosoma mansoni protein kinase 0.0242 0.0229 0.0699
Onchocerca volvulus 0.0329 0.036 0.1103
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.0128 0.0059 0.0122
Echinococcus granulosus tyrosine protein kinase HCK 0.0158 0.0104 0.0282
Trichomonas vaginalis AGC family protein kinase 0.0128 0.0059 0.0399
Schistosoma mansoni vesicular amine transporter 0.0121 0.0048 0.0135
Echinococcus multilocularis serine:threonine protein kinase NLK 0.0128 0.0059 0.0122
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0028 0.0108
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0048 0.0298
Schistosoma mansoni tyrosine kinase 0.0365 0.0414 0.1276
Brugia malayi Protein kinase domain containing protein 0.0495 0.0607 0.0607
Entamoeba histolytica cell division protein kinase 2, putative 0.0718 0.0942 0.3149
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0118 0.0043 0.0043
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Brugia malayi Immunoglobulin I-set domain containing protein 0.052 0.0646 0.0646
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0738 0.0972 1
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0196 0.016 0.1603
Schistosoma mansoni tyrosine kinase 0.0403 0.0471 0.1453
Brugia malayi Cam kinase protein 1 0.0187 0.0147 0.0147
Brugia malayi Variant SH3 domain containing protein 0.0118 0.0043 0.0043
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0221 0.0198 0.0198
Onchocerca volvulus 0.0128 0.0058 0.0163
Echinococcus granulosus tyrosine protein kinase ABL1 0.0341 0.0377 0.1135
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0864 0.1161 0.3083
Entamoeba histolytica protein kinase, putative 0.0138 0.0074 0.0194
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0588 0.0748 0.2295
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Loa Loa (eye worm) hypothetical protein 0.0118 0.0042 0.0042
Echinococcus granulosus Glutaredoxin protein 5 0.0127 0.0056 0.0134
Entamoeba histolytica protein kinase, putative 0.0246 0.0236 0.0745
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0155 0.0099 0.0862
Schistosoma mansoni serine/threonine protein kinase 0.0323 0.035 0.1078
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0487 0.0595 0.1563
Trichomonas vaginalis cAMP-dependent protein kinase catalytic subunit, putative 0.0108 0.0028 0.0108
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0145 0.0084 0.0188
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.044 0.0525 0.1374
Echinococcus multilocularis cyclin dependent kinase 0.0718 0.0942 0.2493
Plasmodium vivax glycogen synthase kinase 3, putative 0.0738 0.0972 1
Brugia malayi cell division control protein 2 homolog 0.0718 0.0942 0.0942
Leishmania major folate/biopterin transporter, putative 0.01 0.0017 0.0129
Loa Loa (eye worm) TK/KIN16 protein kinase 0.052 0.0646 0.0646
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0339 0.0374 0.0967
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0129 0.006 0.006
Brugia malayi Fes/CIP4 homology domain containing protein 0.0262 0.0259 0.0259
Entamoeba histolytica protein kinase, putative 0.0196 0.016 0.0486
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0126 0.0055 0.0112
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Trichomonas vaginalis CK1 family protein kinase 0.0242 0.0229 0.2012
Brugia malayi RhoGAP domain containing protein 0.0118 0.0043 0.0043
Trypanosoma cruzi casein kinase, putative 0.0242 0.0229 0.2216
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0285 0.0293 0.0751
Echinococcus granulosus transient receptor potential ion channel A 0.0113 0.0036 0.0071
Loa Loa (eye worm) gastrulation defective protein 1 0.0267 0.0267 0.0267
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0652 0.0843 0.8647
Echinococcus multilocularis 0.0589 0.0749 0.1977
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0048 0.0298
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0187 0.0147 0.1363
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0136 0.0071 0.0562
Loa Loa (eye worm) hypothetical protein 0.0142 0.0079 0.0079
Trichomonas vaginalis CAMK family protein kinase 0.0145 0.0084 0.0633
Echinococcus multilocularis mitogen activated protein kinase 3 0.0139 0.0075 0.0165
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0281 0.0287 0.0856
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.0074 0.0216
Trichomonas vaginalis AGC family protein kinase 0.0202 0.017 0.1451
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0718 0.0942 0.9687
Plasmodium vivax protein kinase Crk2 0.0718 0.0942 0.9683
Echinococcus granulosus calcium dependent protein kinase 0.01 0.0017 0.001
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0136 0.0071 0.0562
Trichomonas vaginalis CAMK family protein kinase 0.0145 0.0084 0.0633
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0271 0.0273 0.0697
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0227 0.0207 0.1986
Brugia malayi Serine/threonine-protein kinase Pim-3 0.211 0.3026 0.3026
Echinococcus granulosus tyrosine protein kinase Fyn 0.0257 0.0251 0.0742
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Entamoeba histolytica protein kinase, putative 0.036 0.0406 0.1326
Echinococcus granulosus CDC7 cell division cycle 7 0.0803 0.1069 0.3299
Schistosoma mansoni tyrosine kinase 0.0503 0.0621 0.1921
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0755 0.0997 0.3074
Entamoeba histolytica protein kinase domain containing protein 0.0738 0.0972 0.3252
Trichomonas vaginalis CMGC family protein kinase 0.0718 0.0942 0.8793
Echinococcus granulosus serine:threonine protein kinase N2 0.0643 0.083 0.2554
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0718 0.0942 0.9683
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0117 0.0042 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.0652 0.0843 0.2613
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0137 0.0071 0.0181
Schistosoma mansoni serine/threonine protein kinase 0.0128 0.0059 0.017
Trichomonas vaginalis CAMK family protein kinase 0.0495 0.0607 0.5614
Echinococcus granulosus serine:threonine protein kinase 0.0129 0.0059 0.0143
Entamoeba histolytica protein kinase, putative 0.0738 0.0972 0.3252
Echinococcus multilocularis casein kinase i 0.0242 0.0229 0.0578
Echinococcus multilocularis epidermal growth factor receptor 0.0434 0.0516 0.135
Schistosoma mansoni serine/threonine protein kinase 0.0347 0.0386 0.1189
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0192 0.0155 0.0469
Echinococcus granulosus serine:threonine protein kinase PLK1 0.033 0.0361 0.1086
Leishmania major serine/threonine-protein kinase, putative 0.0105 0.0024 0.0204
Echinococcus multilocularis protein kinase shaggy 0.0738 0.0972 0.2575
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0006 0.0005
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0156 0.01 0.01
Trichomonas vaginalis CMGC family protein kinase 0.0196 0.016 0.1356
Echinococcus multilocularis casein kinase I delta 0.0242 0.0229 0.0578
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0675 0.0878 0.2322
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0187 0.0147 0.0359
Trichomonas vaginalis CMGC family protein kinase 0.0156 0.01 0.0789
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0028 0.0108
Entamoeba histolytica PH domain containing protein kinase, putative 0.0227 0.0207 0.0646
Brugia malayi Protein kinase domain containing protein 0.0718 0.0942 0.0942
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0191 0.0153 0.1423
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0118 0.0043 0.008
Schistosoma mansoni rap gtpase-activating protein 0.0325 0.0353 0.1087
Toxoplasma gondii aurora kinase 0.0202 0.017 0.1598
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0208 0.0178 0.0178
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0257 0.0251 0.0637
Schistosoma mansoni protein kinase 0.0251 0.0242 0.0741
Onchocerca volvulus 0.0125 0.0054 0.015
Echinococcus granulosus nervana 2 0.0127 0.0056 0.0134
Entamoeba histolytica PH domain containing protein kinase, putative 0.0689 0.0898 0.3001
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Loa Loa (eye worm) TK/FER protein kinase 0.0128 0.0058 0.0058
Brugia malayi Protein kinase domain containing protein 0.0259 0.0254 0.0254
Echinococcus multilocularis 0.0565 0.0712 0.1877
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0513 0.0634 0.0634
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Loa Loa (eye worm) hypothetical protein 0.0343 0.038 0.038
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0191 0.0153 0.0374
Brugia malayi Egg laying defective protein 4 0.0191 0.0153 0.0153
Giardia lamblia Kinase, AGC PKA 0.0214 0.0187 0.1555
Onchocerca volvulus 0.0128 0.0058 0.0163
Echinococcus granulosus epidermal growth factor receptor 0.0647 0.0836 0.257
Entamoeba histolytica protein kinase, putative 0.0151 0.0093 0.0259
Trypanosoma cruzi cdc2-related kinase 1 0.0718 0.0942 0.9683
Schistosoma mansoni transient receptor potential channel 4 0.0117 0.0042 0.0117
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0126 0.0055 0.013
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.036 0.0406 0.4078
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0675 0.0878 0.2322
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0216 0.019 0.1817
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0738 0.0972 0.2996
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0214 0.0187 0.0465
Schistosoma mansoni serine/threonine-protein kinase 0.0227 0.0207 0.063
Schistosoma mansoni serine/threonine protein kinase 0.1447 0.2033 0.6324
Onchocerca volvulus Tyrosine kinase homolog 0.0407 0.0477 0.1467
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0457 0.0551 0.1444
Echinococcus multilocularis titin 0.0112 0.0035 0.0058
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.016 0.0484
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.0059 0.0399
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0601 0.0766 0.2354
Trichomonas vaginalis STE family protein kinase 0.0193 0.0155 0.1315
Schistosoma mansoni protein kinase 0.0155 0.0099 0.0296
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Trichomonas vaginalis AGC family protein kinase 0.0386 0.0445 0.4074
Entamoeba histolytica protein kinase, putative 0.0202 0.017 0.052
Trichomonas vaginalis CAMK family protein kinase 0.033 0.0361 0.3271
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0048 0.0298
Trichomonas vaginalis STE family protein kinase 0.0173 0.0126 0.1039
Echinococcus granulosus growth factor receptor bound protein 2 0.01 0.0017 0.001
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0214 0.0187 0.1777
Loa Loa (eye worm) hypothetical protein 0.0117 0.0042 0.0042
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0178 0.0133 0.0133
Plasmodium vivax unspecified product 0.0156 0.01 0.0869
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0121 0.0048 0.0298
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.018 0.0137 0.1138
Schistosoma mansoni serine/threonine protein kinase 0.0331 0.0363 0.1116
Echinococcus granulosus dual specificity 0.0196 0.016 0.0457
Leishmania major protein kinase, putative 0.0187 0.0147 0.1474
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0028 0.0108
Toxoplasma gondii histone kinase SNF1, putative 0.0145 0.0084 0.0697
Echinococcus granulosus STE20 serine:threonine protein kinase 0.056 0.0705 0.2161
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Trichomonas vaginalis CMGC family protein kinase 0.0652 0.0843 0.7852
Schistosoma mansoni serine/threonine protein kinase 0.0127 0.0056 0.0161
Echinococcus multilocularis N chimaerin 0.0118 0.0043 0.008
Mycobacterium ulcerans hypothetical protein 0.0104 0.0022 0.5
Schistosoma mansoni serine/threonine kinase 0.0246 0.0236 0.0721
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0192 0.0155 0.0469
Loa Loa (eye worm) TK/ABL protein kinase 0.0341 0.0377 0.0377
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.003 0.008
Echinococcus granulosus casein kinase I delta 0.0242 0.0229 0.0673
Brugia malayi Sex muscle abnormal protein 5 0.0098 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.02 0.0167 0.0167
Plasmodium falciparum serine/threonine protein kinase, putative 0.0202 0.017 0.1598
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0323 0.035 0.035
Echinococcus granulosus casein kinase I gamma 0.0272 0.0273 0.0813
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0202 0.017 0.052
Trichomonas vaginalis AGC family protein kinase 0.0128 0.0059 0.0399
Echinococcus granulosus dual specificity 0.036 0.0406 0.1228
Loa Loa (eye worm) hypothetical protein 0.0325 0.0353 0.0353
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0024 0.0061
Schistosoma mansoni protein kinase C mu 0.0416 0.049 0.1514
Schistosoma mansoni protein kinase 0.0151 0.0093 0.0276
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0251 0.0242 0.0242
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0129 0.0059 0.0059
Echinococcus granulosus cyclin dependent kinase 19 0.0354 0.0397 0.12
Leishmania major protein kinase A catalytic subunit isoform 1 0.0675 0.0878 0.903
Schistosoma mansoni protein kinase 0.0173 0.0126 0.0379
Onchocerca volvulus 0.0325 0.0353 0.1082
Echinococcus multilocularis hypothetical protein 0.0156 0.01 0.0233
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0242 0.0229 0.0229
Trichomonas vaginalis CAMK family protein kinase 0.0371 0.0423 0.3861
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0257 0.0251 0.0637
Echinococcus multilocularis transient receptor potential gamma protein 0.0117 0.0042 0.0077
Trichomonas vaginalis CAMK family protein kinase 0.0145 0.0084 0.0633
Plasmodium falciparum calcium-dependent protein kinase 5 0.0187 0.0147 0.1363
Loa Loa (eye worm) TK/FER protein kinase 0.0128 0.0058 0.0058
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0118 0.0043 0.0121
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0028 0.0108
Echinococcus granulosus aurora kinase A 0.0202 0.017 0.0488
Echinococcus multilocularis transient receptor potential ion channel A 0.0113 0.0036 0.0061
Trichomonas vaginalis CMGC family protein kinase 0.0718 0.0942 0.8793
Brugia malayi Protein kinase domain containing protein 0.0864 0.1161 0.1161
Schistosoma mansoni protein kinase 0.0755 0.0997 0.3094
Leishmania major protein kinase, putative 0.01 0.0017 0.0129
Toxoplasma gondii NEK kinase 0.0105 0.0024 0.0076
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0152 0.0094 0.0217
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0325 0.0353 0.0912
Echinococcus granulosus mitogen activated protein kinase 11 0.0216 0.019 0.0553
Plasmodium falciparum NIMA related kinase 1 0.0193 0.0155 0.1448
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.036 0.0406 0.4078
Echinococcus granulosus tyrosine protein kinase Blk 0.0218 0.0193 0.0562
Trichomonas vaginalis AGC family protein kinase 0.0288 0.0298 0.267
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0668 0.0867 0.0867
Echinococcus granulosus c src tyrosine kinase 0.0166 0.0116 0.032
Brugia malayi hypothetical protein 0.0281 0.0287 0.0287
Trichomonas vaginalis CMGC family protein kinase 0.0738 0.0972 0.9081
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.017 0.0515
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0187 0.0147 0.0359
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0048 0.0298
Giardia lamblia Aurora kinase 0.0202 0.017 0.1392
Brugia malayi cyclin-dependent kinase 9 0.0323 0.035 0.035
Echinococcus multilocularis mitogen activated protein kinase 11 0.0216 0.019 0.0475
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0193 0.0155 0.1448
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0075 0.055
Trypanosoma cruzi casein kinase II, putative 0.0156 0.01 0.0869
Entamoeba histolytica protein kinase, putative 0.0373 0.0425 0.1391
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0028 0.0108
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.211 0.3026 0.9419
Brugia malayi SH2 domain containing protein 0.0128 0.0058 0.0058
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.049 0.06 0.06
Schistosoma mansoni serine/threonine protein kinase 0.033 0.0361 0.1111
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1063 0.1459 0.4519
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0331 0.0363 0.0363
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0246 0.0236 0.0695
Brugia malayi map kinase activated protein kinase protein 2 0.0457 0.0551 0.0551
Trichomonas vaginalis STE family protein kinase 0.0173 0.0126 0.1039
Trypanosoma cruzi polo-like protein kinase, putative 0.033 0.0361 0.3602
Loa Loa (eye worm) AGC/PKN protein kinase 0.0643 0.083 0.083
Plasmodium falciparum NIMA related kinase 2 0.0105 0.0024 0.0076
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0028 0.0108
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0567 0.0716 0.0716
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0221 0.0198 0.0496
Echinococcus granulosus ephrin type A receptor 4 A 0.0134 0.0067 0.0168
Giardia lamblia Kinase, CMGC CK2 0.0156 0.01 0.0725
Trichomonas vaginalis CMGC family protein kinase 0.0156 0.01 0.0789
Trypanosoma brucei Serine/threonine-protein kinase NEK11, putative 0.0105 0.0024 0.0076
Entamoeba histolytica p21-activated kinase 0.0187 0.0146 0.044
Schistosoma mansoni titin 0.0112 0.0035 0.0095
Echinococcus multilocularis serine:threonine protein kinase N2 0.0397 0.0461 0.1202
Entamoeba histolytica protein kinase, putative 0.0165 0.0113 0.0327
Schistosoma mansoni serine/threonine protein kinase 0.052 0.0645 0.1997
Echinococcus multilocularis PAK box P21 Rho binding 0.0151 0.0093 0.0213
Brugia malayi Protein kinase domain containing protein 0.0267 0.0267 0.0267
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0145 0.0084 0.0697
Brugia malayi Protein kinase domain containing protein 0.0117 0.0041 0.0041
Brugia malayi Doublecortin family protein 0.0208 0.0178 0.0178
Schistosoma mansoni protein kinase 0.0173 0.0126 0.0379
Echinococcus multilocularis myosin iiia 0.0192 0.0155 0.0379
Brugia malayi Protein kinase domain containing protein 0.0137 0.0071 0.0071
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0024 0.0069
Leishmania major protein kinase A catalytic subunit isoform 2 0.0675 0.0878 0.903
Schistosoma mansoni serine/threonine protein kinase 0.0243 0.0231 0.0705
Schistosoma mansoni tyrosine kinase 0.0271 0.0273 0.0837
Brugia malayi Protein kinase domain containing protein 0.0354 0.0397 0.0397
Loa Loa (eye worm) TK/FER protein kinase 0.0128 0.0058 0.0058
Echinococcus multilocularis nervana 2 0.0127 0.0056 0.0115
Schistosoma mansoni protein kinase 0.0755 0.0997 0.3094
Echinococcus granulosus cyclin dependent kinase 9 0.0364 0.0412 0.1247
Onchocerca volvulus 0.0155 0.0098 0.0286
Echinococcus multilocularis protein kinase c iota type 0.039 0.045 0.1173
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0261 0.0258 0.0764
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0325 0.0353 0.1062
Leishmania major mitogen-activated protein kinase, putative,map kinase-like protein 0.0128 0.0059 0.0563
Trypanosoma cruzi aurora B kinase, putative 0.0202 0.017 0.1598
Brugia malayi Temporarily assigned gene name protein 59 0.0325 0.0353 0.0353
Trichomonas vaginalis CAMK family protein kinase 0.033 0.0361 0.3271
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0028 0.0108
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0192 0.0155 0.1443
Schistosoma mansoni tyrosine kinase 0.0257 0.0251 0.0768
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0109 0.003 0.0126
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0147 0.0087 0.0237
Schistosoma mansoni serine/threonine protein kinase 0.0803 0.1069 0.3317
Echinococcus multilocularis dual specificity 0.0196 0.016 0.0392
Loa Loa (eye worm) TK protein kinase 0.0201 0.0168 0.0168
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0118 0.0043 0.0094
Echinococcus multilocularis roundabout 2 0.0157 0.0102 0.0238
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0196 0.016 0.016
Brugia malayi Protein kinase domain containing protein 0.0128 0.0058 0.0058
Onchocerca volvulus 0.0242 0.0229 0.0693
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0257 0.0251 0.0637
Echinococcus granulosus transient receptor potential gamma protein 0.0117 0.0042 0.0089
Loa Loa (eye worm) TK/FER protein kinase 0.0128 0.0058 0.0058
Onchocerca volvulus 0.0128 0.0058 0.0163
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.0147 0.0445
Echinococcus multilocularis Immunoglobulin 0.0117 0.0042 0.0077
Loa Loa (eye worm) TK/ALK protein kinase 0.0311 0.0332 0.0332
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0202 0.0169 0.0485
Brugia malayi p70 ribosomal S6 kinase beta 0.0373 0.0425 0.0425
Schistosoma mansoni tyrosine kinase 0.048 0.0586 0.1813
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0187 0.0147 0.1363
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0026 0.0066
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0128 0.0059 0.0439
Giardia lamblia Kinase, NEK 0.0193 0.0155 0.1255
Echinococcus multilocularis tyrosine protein kinase HCK 0.0158 0.0104 0.0243
Echinococcus multilocularis cyclin dependent kinase 1 0.0718 0.0942 0.2493
Echinococcus granulosus serine:threonine kinase SAD 1 0.0145 0.0084 0.0219
Trichomonas vaginalis CMGC family protein kinase 0.0803 0.1069 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0563 0.071 0.1871
Echinococcus multilocularis casein kinase I alpha 0.0242 0.0229 0.0578
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0048 0.0298
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.0059 0.0399
Echinococcus multilocularis cyclin dependent kinase 7 0.049 0.06 0.1575
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0214 0.0187 0.1777
Trichomonas vaginalis CAMK family protein kinase 0.0145 0.0084 0.0633
Schistosoma mansoni serine/threonine protein kinase 0.0675 0.0878 0.2723
Schistosoma mansoni serine/threonine protein kinase 0.0243 0.0231 0.0705
Plasmodium vivax serine/threonine-protein kinase NEK4, putative 0.0105 0.0024 0.0076
Trichomonas vaginalis CAMK family protein kinase 0.0145 0.0084 0.0633
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0325 0.0353 0.3519
Loa Loa (eye worm) hypothetical protein 0.0117 0.0042 0.0042
Toxoplasma gondii casein kinase I 0.0242 0.0229 0.2216
Brugia malayi MAP kinase sur-1 0.0139 0.0075 0.0075
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.0059 0.0399
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0675 0.0878 0.2703
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0187 0.0147 0.1363
Loa Loa (eye worm) hypothetical protein 0.0145 0.0084 0.0084
Loa Loa (eye worm) TK/FER protein kinase 0.0128 0.0058 0.0058
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0187 0.0147 0.0147
Entamoeba histolytica protein kinase domain containing protein 0.2061 0.2953 1
Entamoeba histolytica protein kinase, putative 0.0202 0.017 0.052
Echinococcus multilocularis Immunoglobulin 0.0117 0.0042 0.0077
Entamoeba histolytica protein kinase, putative 0.0138 0.0074 0.0194
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0325 0.0353 0.3519
Leishmania major protein kinase, putative 0.0652 0.0843 0.8664
Echinococcus multilocularis neuroglian 0.0136 0.0071 0.0154
Trypanosoma cruzi Serine/threonine-protein kinase NEK16, putative 0.0105 0.0024 0.0076
Plasmodium vivax casein kinase 1, putative 0.0242 0.0229 0.2216
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0187 0.0147 0.1363
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0187 0.0147 0.1363
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0259 0.0254 0.0254
Echinococcus multilocularis serine:threonine protein kinase N2 0.0643 0.083 0.2194
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0214 0.0187 0.1777
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0428 0.0508 0.0508
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0358 0.0403 0.0403
Echinococcus multilocularis death associated protein kinase 1 0.2584 0.3736 1
Echinococcus multilocularis casein kinase I delta 0.0242 0.0229 0.0578
Brugia malayi Immunoglobulin I-set domain containing protein 0.0123 0.0051 0.0051
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0196 0.016 0.1493
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0373 0.0425 0.0425
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0109 0.003 0.003
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0155 0.0099 0.0862
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0048 0.0298
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0117 0.0042 0.0077
Brugia malayi serine/threonine kinase 12 0.0202 0.017 0.017
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0325 0.0353 0.1087
Echinococcus granulosus protein kinase c iota type 0.039 0.045 0.1365
Schistosoma mansoni growth factor receptor-bound protein 0.0098 0.0013 0.0028
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0187 0.0147 0.0147
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0173 0.0126 0.0352
Echinococcus granulosus casein kinase I alpha 0.0242 0.0229 0.0673
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0075 0.055
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0675 0.0878 0.9017
Trichomonas vaginalis G protein-coupled receptor kinase, putative 0.0128 0.0059 0.0399
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0028 0.0108
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0495 0.0607 0.0607
Echinococcus granulosus tyrosine protein kinase Fyn 0.0257 0.0251 0.0742
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0024 0.0069
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.0059 0.0399
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.036 0.0406 0.4154
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0675 0.0878 0.9017
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0155 0.0099 0.0862
Schistosoma mansoni protein kinase 0.0589 0.0749 0.2322
Entamoeba histolytica protein kinase, putative 0.036 0.0406 0.1326
Echinococcus granulosus Cell division cycle 2 protein kinase 0.0128 0.0059 0.0142
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.2061 0.2953 0.7896
Echinococcus granulosus mitogen activated protein kinase 3 0.0139 0.0075 0.0192
Trichomonas vaginalis CAMK family protein kinase 0.033 0.0361 0.3271
Schistosoma mansoni protein kinase 0.0156 0.01 0.0298
Leishmania major protein kinase, putative 0.0652 0.0843 0.8664
Trichomonas vaginalis CMGC family protein kinase 0.0196 0.016 0.1356
Plasmodium falciparum cGMP-dependent protein kinase 0.0191 0.0153 0.1423
Brugia malayi serine/threonine-protein kinase plk-2 0.033 0.0361 0.0361
Schistosoma mansoni serine/threonine protein kinase 0.0281 0.0287 0.0882
Onchocerca volvulus 0.2234 0.3212 1
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.0055 0.0158
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.0128 0.0059 0.0059
Trichomonas vaginalis CMGC family protein kinase 0.0196 0.016 0.1356
Trichomonas vaginalis CAMK family protein kinase 0.0145 0.0084 0.0633
Trypanosoma brucei rac serine-threonine kinase, putative 0.0386 0.0445 0.4487
Brugia malayi protein kinase C II. 0.0306 0.0325 0.0325
Schistosoma mansoni tyrosine kinase 0.0434 0.0516 0.1595
Plasmodium falciparum glycogen synthase kinase 3 0.0738 0.0972 1
Loa Loa (eye worm) TK protein kinase 0.0291 0.0302 0.0302
Brugia malayi Protein kinase domain containing protein 0.0246 0.0236 0.0236
Loa Loa (eye worm) casein kinase 0.0185 0.0143 0.0143
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0137 0.0071 0.0071
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0173 0.0126 0.0303
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0416 0.049 0.049
Brugia malayi Protein kinase domain containing protein 0.0272 0.0273 0.0273
Trichomonas vaginalis CAMK family protein kinase 0.033 0.0361 0.3271
Onchocerca volvulus 0.0343 0.038 0.1165
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0128 0.0059 0.0439
Echinococcus multilocularis tyrosine protein kinase Blk 0.0218 0.0193 0.0483
Echinococcus multilocularis casein kinase ii subunit alpha 0.0156 0.01 0.0232
Trichomonas vaginalis AGC family protein kinase 0.0202 0.017 0.1451
Brugia malayi Kinase associated domain 1 family protein 0.0156 0.01 0.01
Brugia malayi Protein kinase domain containing protein 0.0128 0.0059 0.0059
Schistosoma mansoni serine/threonine protein kinase 0.0643 0.083 0.2575
Echinococcus granulosus tyrosine protein kinase shark 0.0563 0.071 0.2178
Trichomonas vaginalis CAMK family protein kinase 0.033 0.0361 0.3271
Schistosoma mansoni serine/threonine protein kinase 0.0171 0.0122 0.0367
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0589 0.0749 0.0749
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0196 0.016 0.016
Schistosoma mansoni serine/threonine protein kinase 0.0285 0.0293 0.0899
Giardia lamblia Kinase, CMGC GSK 0.0738 0.0972 0.9075
Brugia malayi serine/threonine-protein kinase PAK 7 0.0665 0.0862 0.0862
Trichomonas vaginalis STE family protein kinase 0.0192 0.0155 0.131
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0354 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0142 0.0079 0.0079
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0675 0.0878 0.0878
Trichomonas vaginalis CMGC family protein kinase 0.0196 0.016 0.1356
Onchocerca volvulus 0.2147 0.3082 0.9593
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0457 0.0551 0.0551
Schistosoma mansoni serine/threonine protein kinase 0.0145 0.0084 0.0246
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0675 0.0878 0.2322
Trypanosoma brucei Serine/threonine-protein kinase NEK16, putative 0.0105 0.0024 0.0076
Trichomonas vaginalis CAMK family protein kinase 0.0183 0.014 0.1172
Echinococcus granulosus tyrosine protein kinase Src42A 0.0257 0.0251 0.0742
Schistosoma mansoni adapter molecule crk 0.0098 0.0013 0.0028
Loa Loa (eye worm) hypothetical protein 0.0128 0.0058 0.0058
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0738 0.0972 0.3016
Echinococcus multilocularis expressed protein 0.0138 0.0074 0.0162
Brugia malayi Cell division protein kinase 2 0.0128 0.0059 0.0059
Echinococcus multilocularis cyclin dependent kinase 19 0.0354 0.0397 0.1031
Echinococcus granulosus tyrosine protein kinase Srms 0.0546 0.0684 0.2096
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0028 0.0108
Brugia malayi Protein kinase domain containing protein 0.048 0.0586 0.0586
Toxoplasma gondii AGC kinase 0.0675 0.0878 0.9017
Onchocerca volvulus 0.0128 0.0058 0.0163
Trypanosoma brucei protein kinase, putative 0.018 0.0137 0.1255
Loa Loa (eye worm) hypothetical protein 0.0123 0.0051 0.0051
Onchocerca volvulus 0.032 0.0345 0.1058
Brugia malayi Fibronectin type III domain containing protein 0.0123 0.0051 0.0051
Trichomonas vaginalis CK1 family protein kinase 0.0242 0.0229 0.2012
Schistosoma mansoni hypothetical protein 0.0325 0.0353 0.1087
Echinococcus granulosus protein kinase C gamma type 0.0288 0.0298 0.0891
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0028 0.0108
Loa Loa (eye worm) TK/FER protein kinase 0.0128 0.0058 0.0058
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0145 0.0084 0.0084
Trichomonas vaginalis AGC family protein kinase 0.0675 0.0878 0.8188
Schistosoma mansoni serine/threonine protein kinase 0.0137 0.0071 0.0209
Schistosoma mansoni serine/threonine protein kinase 0.052 0.0645 0.1997
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0132 0.0064 0.0159
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0173 0.0126 0.0352
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0283 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0675 0.0878 0.2723
Brugia malayi Protein kinase domain containing protein 0.0128 0.0058 0.0058
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.052 0.0645 0.1975
Echinococcus multilocularis serine:threonine protein kinase 0.0129 0.0059 0.0123
Entamoeba histolytica protein kinase, putative 0.0189 0.0149 0.045
Schistosoma mansoni ephrin receptor 0.0134 0.0067 0.0195
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Schistosoma mansoni tyrosine kinase 0.0281 0.0287 0.0881
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0048 0.0298
Loa Loa (eye worm) hypothetical protein 0.0827 0.1105 0.1105
Entamoeba histolytica protein kinase, putative 0.0147 0.0087 0.0237
Trypanosoma brucei Mitogen-activated protein kinase 10, putative 0.0128 0.0059 0.0439
Schistosoma mansoni serine/threonine protein kinase 0.0718 0.0942 0.2922
Giardia lamblia Kinase, NEK 0.0193 0.0155 0.1255
Schistosoma mansoni protein kinase 0.0128 0.0059 0.017
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0155 0.0099 0.0862
Trichomonas vaginalis CAMK family protein kinase 0.0339 0.0374 0.3391
Echinococcus multilocularis epidermal growth factor receptor 0.0647 0.0836 0.2208
Echinococcus granulosus tyrosine protein kinase Src64B 0.0257 0.0251 0.0742
Echinococcus granulosus titin 0.0112 0.0035 0.0067
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.01 0.0017 0.0129
Entamoeba histolytica protein kinase domain containing protein 0.0738 0.0972 0.3252
Echinococcus granulosus hypothetical protein 0.0565 0.0712 0.2185
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0331 0.0363 0.1091
Schistosoma mansoni serine/threonine protein kinase 0.0191 0.0153 0.0463
Trypanosoma cruzi polo-like protein kinase, putative 0.033 0.0361 0.3602
Echinococcus granulosus mitogen activated protein kinase 0.0139 0.0075 0.0192
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0187 0.0147 0.0418
Echinococcus granulosus cyclin dependent kinase 1 0.0718 0.0942 0.2902
Echinococcus multilocularis rho associated protein kinase 0.2234 0.3212 0.8592
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0216 0.019 0.1817
Brugia malayi serine/threonine-protein kinase 6 0.0202 0.017 0.017
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0028 0.0108
Entamoeba histolytica protein kinase, putative 0.0173 0.0126 0.0372
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0185 0.0144 0.144
Schistosoma mansoni serine/threonine protein kinase 0.0139 0.0075 0.0219
Brugia malayi SH2 domain containing protein 0.0261 0.0258 0.0258
Echinococcus multilocularis tyrosine protein kinase Abl 0.0248 0.0237 0.0602
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.2061 0.2953 0.2953
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0567 0.0716 0.0716
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0675 0.0878 0.9017
Schistosoma mansoni tyrosine kinase 0.0365 0.0414 0.1276
Plasmodium falciparum calcium-dependent protein kinase 1 0.0187 0.0147 0.1363
Trichomonas vaginalis CMGC family protein kinase 0.0803 0.1069 1
Echinococcus multilocularis calcium dependent protein kinase 0.01 0.0017 0.0009
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0028 0.0108
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0071 0.0517
Plasmodium falciparum calcium-dependent protein kinase 2 0.0187 0.0147 0.1363
Brugia malayi Protein kinase domain containing protein 0.0513 0.0634 0.0634
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0652 0.0843 0.8647
Trichomonas vaginalis AGC family protein kinase 0.0128 0.0059 0.0399
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0109 0.003 0.0139
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0048 0.0298
Trypanosoma brucei protein kinase, putative 0.0738 0.0972 1
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0202 0.017 0.052
Echinococcus multilocularis Glutaredoxin protein 5 0.0127 0.0056 0.0115
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0048 0.0298
Plasmodium falciparum NIMA related kinase 4 0.0105 0.0024 0.0076
Brugia malayi Protein kinase domain containing protein 0.0093 0.0006 0.0006
Schistosoma mansoni protein kinase 0.0914 0.1236 0.3839
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0127 0.0057 0.0057
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0257 0.0251 0.0637
Trichomonas vaginalis AGC family protein kinase 0.0386 0.0445 0.4074
Schistosoma mansoni serine/threonine protein kinase 0.0324 0.0352 0.1083
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0652 0.0843 0.8647
Entamoeba histolytica protein kinase domain containing protein 0.0323 0.035 0.1136
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.01 0.0283
Echinococcus granulosus serine threonine protein kinase nrc 0.0214 0.0187 0.0541
Plasmodium falciparum casein kinase 1 0.0242 0.0229 0.2216
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0257 0.0251 0.0742
Schistosoma mansoni serine/threonine protein kinase 0.0259 0.0254 0.0779
Trichomonas vaginalis serine/threonine kinase, putative 0.0128 0.0059 0.0399
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0675 0.0878 0.9017
Trichomonas vaginalis CMGC family protein kinase 0.0156 0.01 0.0789
Trichomonas vaginalis CAMK family protein kinase 0.0145 0.0084 0.0633
Echinococcus granulosus Vam6:Vps39 protein 0.0325 0.0353 0.1062
Trypanosoma cruzi Serine/threonine-protein kinase NEK11, putative 0.0105 0.0024 0.0076
Schistosoma mansoni serine/threonine protein kinase 0.036 0.0406 0.1253
Onchocerca volvulus 0.0128 0.0058 0.0163
Trypanosoma cruzi casein kinase, putative 0.0242 0.0229 0.2216
Schistosoma mansoni tyrosine kinase 0.0563 0.071 0.22
Loa Loa (eye worm) AGC/PKG protein kinase 0.0191 0.0153 0.0153
Trichomonas vaginalis CMGC family protein kinase 0.0156 0.01 0.0789
Trichomonas vaginalis CAMK family protein kinase 0.0129 0.0059 0.0402
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0048 0.0298
Giardia lamblia Kinase, NEK 0.0193 0.0155 0.1255
Plasmodium falciparum MO15-related protein kinase 0.0128 0.0059 0.0439
Echinococcus multilocularis expressed conserved protein 0.0191 0.0153 0.0374
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0145 0.0084 0.0817
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0048 0.0298
Echinococcus granulosus tyrosine protein kinase Lyn 0.0344 0.0381 0.115
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0187 0.0147 0.1363
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0244 0.0231 0.0231
Echinococcus multilocularis cyclin dependent kinase 9 0.0364 0.0412 0.1072
Echinococcus multilocularis mitogen activated protein kinase 14 0.0216 0.019 0.0475
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0347 0.0386 0.1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0139 0.0075 0.0606
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0048 0.0298
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0192 0.0155 0.1443
Plasmodium falciparum protein kinase, putative 0.0155 0.0099 0.0862
Schistosoma mansoni kinase 0.0323 0.035 0.1078
Trichomonas vaginalis CMGC family protein kinase 0.0156 0.01 0.0789
Echinococcus granulosus rho-associated protein kinase 1 0.2234 0.3212 1
Echinococcus granulosus cGMP dependent protein kinase 1 0.0191 0.0153 0.0436
Trichomonas vaginalis CMGC family protein kinase 0.0156 0.01 0.0789
Echinococcus granulosus twitchin 0.0223 0.0201 0.0587
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.033 0.0361 0.3685
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0098 0.0013 0.0013
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0138 0.0074 0.0596
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0285 0.0293 0.0874
Brugia malayi protein unc-22 0.0112 0.0035 0.0035
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0738 0.0972 0.0972
Echinococcus multilocularis serine:threonine protein kinase 38 0.0246 0.0236 0.0597
Trichomonas vaginalis CAMK family protein kinase 0.0145 0.0084 0.0633
Echinococcus granulosus serine:threonine protein kinase 0.0129 0.0059 0.0143
Entamoeba histolytica protein kinase domain containing protein 0.0202 0.017 0.052
Brugia malayi intracellular kinase 0.0738 0.0972 0.0972
Giardia lamblia Kinase, CAMK CAMKL 0.0186 0.0145 0.1162
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0242 0.0229 0.0229
Brugia malayi Protein kinase domain containing protein 0.0221 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0132 0.0064 0.0064
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0242 0.0229 0.0229
Echinococcus multilocularis CDC7 cell division cycle 7 0.0803 0.1069 0.2834
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0048 0.0298
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0675 0.0878 0.9017
Trypanosoma cruzi NIMA-related kinase, putative 0.0105 0.0024 0.0076
Echinococcus multilocularis aurora kinase A 0.0202 0.017 0.0419
Entamoeba histolytica protein kinase, putative 0.0126 0.0055 0.013
Loa Loa (eye worm) AGC/NDR protein kinase 0.0246 0.0236 0.0236
Trichomonas vaginalis STE family protein kinase 0.0173 0.0126 0.1039
Brugia malayi Hr1 repeat family protein 0.0643 0.083 0.083
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Trichomonas vaginalis CAMK family protein kinase 0.0145 0.0084 0.0633
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0324 0.0352 0.0909
Brugia malayi Protein kinase domain 0.0173 0.0126 0.0126
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0186 0.0145 0.1346
Loa Loa (eye worm) TK/FER protein kinase 0.0128 0.0058 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0718 0.0942 0.9687
Entamoeba histolytica casein kinase, putative 0.0156 0.01 0.0283
Brugia malayi P38 map kinase family protein 2 0.0216 0.019 0.019
Loa Loa (eye worm) CDC7 protein kinase 0.0803 0.1069 0.1069
Loa Loa (eye worm) TK/FER protein kinase 0.0128 0.0058 0.0058
Trypanosoma cruzi p21-activated kinase 3, putative 0.0109 0.003 0.0139
Toxoplasma gondii AGC kinase 0.0675 0.0878 0.9017
Echinococcus multilocularis dual specificity 0.036 0.0406 0.1055
Schistosoma mansoni protein kinase 0.0202 0.017 0.0515
Loa Loa (eye worm) TK/FER protein kinase 0.0261 0.0258 0.0258
Trypanosoma cruzi cdc2-related kinase 3 0.0718 0.0942 0.9683
Brugia malayi C1-like domain containing protein 0.0416 0.049 0.049
Echinococcus granulosus c-Jun N-terminal kinases 0.0324 0.0352 0.1058
Echinococcus multilocularis serine:threonine protein kinase 0.0129 0.0059 0.0123
Brugia malayi Serine/threonine-protein kinase SULU 0.0281 0.0287 0.0287
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0216 0.019 0.1923
Onchocerca volvulus Serine\/threonine kinase homolog 0.0221 0.0198 0.0598
Schistosoma mansoni tyrosine kinase 0.0257 0.0251 0.0768
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0028 0.0108
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0035 0.0095
Echinococcus granulosus serine:threonine protein kinase NLK 0.0128 0.0059 0.0142
Schistosoma mansoni serine/threonine protein kinase 0.0244 0.0231 0.0707
Trichomonas vaginalis serine/threonine-protein kinase ypk, putative 0.0108 0.0028 0.0108
Brugia malayi STE20-like kinase MST 0.0543 0.068 0.068
Trichomonas vaginalis serine/threonine-protein kinase, putative 0.0108 0.0028 0.0108
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0652 0.0843 0.8647
Brugia malayi Protein kinase domain containing protein 0.0128 0.0058 0.0058
Brugia malayi Tyrosine-protein kinase abl-1 0.0248 0.0237 0.0237
Leishmania major protein kinase, putative,serine/threonine-protein kinase Nek1, putative 0.0105 0.0024 0.0204
Trichomonas vaginalis CAMK family protein kinase 0.0145 0.0084 0.0633
Schistosoma mansoni serine/threonine protein kinase 0.0145 0.0084 0.0246
Schistosoma mansoni tyrosine kinase 0.0647 0.0836 0.2591
Echinococcus granulosus tyrosine protein kinase Src42A 0.0152 0.0094 0.0252
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.036 0.0406 0.4078
Echinococcus multilocularis NCK adaptor protein 0.01 0.0017 0.0008
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0202 0.017 0.1598
Brugia malayi Protein kinase domain containing protein 0.036 0.0406 0.0406
Entamoeba histolytica protein kinase, putative 0.0126 0.0055 0.013
Loa Loa (eye worm) AGC/PKA protein kinase 0.0675 0.0878 0.0878
Echinococcus granulosus casein kinase ii subunit alpha 0.0156 0.01 0.027
Trichomonas vaginalis STE family protein kinase 0.0105 0.0024 0.0069
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0244 0.0231 0.0681
Trichomonas vaginalis CMGC family protein kinase 0.0196 0.016 0.1356
Trichomonas vaginalis AGC family protein kinase 0.0193 0.0155 0.1315
Brugia malayi ephrin receptor 1 precursor 0.0099 0.0015 0.0015
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0202 0.017 0.0419
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.0093 0.0006 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0028 0.0108
Echinococcus multilocularis cyclin dependent kinase 1 0.0718 0.0942 0.2493
Echinococcus granulosus casein kinase I alpha 0.0242 0.0229 0.0673
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0257 0.0251 0.0742
Trichomonas vaginalis AGC family protein kinase 0.0386 0.0445 0.4074
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0075 0.055
Loa Loa (eye worm) hypothetical protein 0.0151 0.0093 0.0093
Brugia malayi protein kinase C3,putative 0.023 0.0211 0.0211
Echinococcus granulosus N chimaerin 0.0118 0.0043 0.0094
Giardia lamblia Kinase, AGC PKA 0.0675 0.0878 0.8176
Echinococcus multilocularis serine threonine protein kinase 0.0288 0.0298 0.0766
Leishmania major protein kinase, putative 0.0155 0.0099 0.098
Brugia malayi Homeodomain interacting protein kinase protein 1 0.2061 0.2953 0.2953
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0187 0.0147 0.0418
Schistosoma mansoni protein kinase 0.0155 0.0099 0.0296
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0024 0.0069
Echinococcus multilocularis insulin receptor 0.048 0.0586 0.1538
Loa Loa (eye worm) hypothetical protein 0.0123 0.0051 0.0051
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0139 0.0075 0.0606
Trypanosoma brucei cdc2-related kinase 1 0.0718 0.0942 0.9683
Schistosoma mansoni tyrosine kinase 0.0166 0.0116 0.0347
Schistosoma mansoni cell adhesion molecule 0.0138 0.0074 0.0215
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0281 0.0287 0.0287
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0173 0.0126 0.0352
Echinococcus multilocularis calcium activated potassium channel 0.0247 0.0237 0.0599
Loa Loa (eye worm) hypothetical protein 0.0117 0.0042 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.0145 0.0084 0.0246
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0755 0.0997 0.2642
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.003 0.008
Schistosoma mansoni serine/threonine protein kinase 0.049 0.06 0.1857
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0718 0.0942 0.2902
Loa Loa (eye worm) CAMK/PIM protein kinase 0.211 0.3026 0.3026
Trichomonas vaginalis CMGC family protein kinase 0.0718 0.0942 0.8793
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Schistosoma mansoni serine/threonine protein kinase 0.049 0.06 0.1857
Plasmodium falciparum calcium-dependent protein kinase 4 0.0187 0.0147 0.1363
Echinococcus multilocularis serine:threonine protein kinase N2 0.0246 0.0236 0.0597
Brugia malayi Protein kinase domain containing protein 0.0128 0.0058 0.0058
Toxoplasma gondii NEK kinase 0.0105 0.0024 0.0076
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0738 0.0972 1
Giardia lamblia Kinase, PLK 0.033 0.0361 0.3225
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0202 0.017 0.0488
Echinococcus granulosus activin receptor type 0.0155 0.0099 0.0268
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0457 0.0551 0.1681
Schistosoma mansoni serine/threonine protein kinase 0.2061 0.2953 0.9192
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0059 0.0399
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0668 0.0867 0.0867
Leishmania major casein kinase II, putative 0.0156 0.01 0.0987
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0216 0.019 0.1817
Entamoeba histolytica protein kinase, putative 0.0158 0.0104 0.0296
Trypanosoma brucei cdc2-related kinase 3 0.0718 0.0942 0.9683
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0138 0.0074 0.0074
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0718 0.0942 0.0942
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0028 0.0108
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0341 0.0377 0.0975
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0416 0.049 0.049
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0306 0.0325 0.0325
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0218 0.0193 0.0562
Entamoeba histolytica casein kinase, putative 0.0242 0.0229 0.0721
Schistosoma mansoni serine/threonine protein kinase 0.211 0.3026 0.9421
Brugia malayi Protein kinase domain containing protein 0.0138 0.0074 0.0074
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0138 0.0074 0.0717
Onchocerca volvulus 0.0112 0.0035 0.0089
Giardia lamblia Kinase, CMGC DYRK 0.0196 0.016 0.1296
Schistosoma mansoni hypothetical protein 0.0156 0.01 0.0299
Brugia malayi Casein kinase II, alpha chain 0.0156 0.01 0.01
Schistosoma mansoni serine/threonine protein kinase 0.0221 0.0198 0.0604
Schistosoma mansoni serine/threonine-protein kinase 0.0227 0.0207 0.063
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0652 0.0843 0.8647
Echinococcus granulosus protein kinase shaggy 0.0738 0.0972 0.2996

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 0.2667 uM PUBCHEM_BIOASSAY: Confirmation dose response assay for compounds that inhibit transient receptor potential cation channel C4 (TRPC4). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2247, AID2256] ChEMBL. No reference
IC50 (functional) = 5.066 uM PUBCHEM_BIOASSAY: TRFRET-based biochemical high throughput dose response assay for inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.5623 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.