Detailed information for compound 353439

Basic information

Technical information
  • TDR Targets ID: 353439
  • Name: N'-propyl-N-(1,3,4-trioxoisoquinolin-6-yl)but anediamide
  • MW: 331.323 | Formula: C16H17N3O5
  • H donors: 3 H acceptors: 5 LogP: -0.15 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCNC(=O)CCC(=O)Nc1ccc2c(c1)C(=O)C(=O)NC2=O
  • InChi: 1S/C16H17N3O5/c1-2-7-17-12(20)5-6-13(21)18-9-3-4-10-11(8-9)14(22)16(24)19-15(10)23/h3-4,8H,2,5-7H2,1H3,(H,17,20)(H,18,21)(H,19,23,24)
  • InChiKey: ZHRVSZKDLXIFPF-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N'-propyl-N-(1,3,4-trioxo-6-isoquinolyl)butanediamide
  • N'-propyl-N-(1,3,4-triketo-6-isoquinolyl)succinamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens caspase 3, apoptosis-related cysteine peptidase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus caspase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma mansoni caspase-7 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum ko:K02187 caspase 3, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum ko:K04397 caspase 7, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma mansoni caspase-3 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cell death protein 3 precursor caspase 3, apoptosis-related cysteine peptidase 277 aa 253 aa 38.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cGMP dependent protein kinase 1 0.0251 0.0066 0.0162
Echinococcus granulosus tyrosine protein kinase Lyn 0.0696 0.0477 0.1451
Echinococcus granulosus activated cdc42 kinase 1 0.0727 0.0505 0.154
Brugia malayi Egg laying defective protein 4 0.0251 0.0066 0.0065
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0316 0.0126 0.0351
Trichomonas vaginalis AGC family protein kinase 0.0454 0.0253 0.2411
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0303 0.0114 0.1087
Trichomonas vaginalis AGC family protein kinase 0.0465 0.0263 0.251
Leishmania major protein kinase A catalytic subunit 0.1146 0.0892 0.8492
Plasmodium falciparum protein kinase, putative 0.0319 0.0128 0.1153
Schistosoma mansoni serine/threonine protein kinase 0.1146 0.0892 0.2784
Echinococcus granulosus hypothetical protein 0.1154 0.09 0.2778
Loa Loa (eye worm) hypothetical protein 0.0688 0.0469 0.0468
Echinococcus multilocularis neuroglian 0.0444 0.0244 0.0396
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.1217 0.0958 0.0957
Loa Loa (eye worm) hypothetical protein 0.0598 0.0387 0.0386
Schistosoma mansoni serine/threonine protein kinase 0.1451 0.1175 0.3665
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0447 0.0247 0.0401
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.0101 0.096
Plasmodium falciparum protein kinase 5 0.1217 0.0958 0.9122
Onchocerca volvulus 0.0816 0.0588 0.1719
Brugia malayi Immunoglobulin I-set domain containing protein 0.0377 0.0183 0.0182
Schistosoma mansoni serine/threonine protein kinase 0.3601 0.316 0.9867
Echinococcus granulosus protein tyrosine kinase 0.1026 0.0781 0.2406
Echinococcus granulosus cyclin dependent kinase 0.1217 0.0958 0.296
Loa Loa (eye worm) TK/FER protein kinase 0.029 0.0102 0.0101
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0704 0.0485 0.0811
Echinococcus multilocularis cyclin dependent kinase 1 0.1217 0.0958 0.1626
Trichomonas vaginalis STE family protein kinase 0.0316 0.0126 0.12
Onchocerca volvulus 0.3648 0.3203 1
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0592 0.0381 0.038
Echinococcus multilocularis serine:threonine protein kinase 38 0.0447 0.0247 0.0401
Brugia malayi Fibronectin type III domain containing protein 0.0377 0.0183 0.0182
Echinococcus multilocularis mitogen activated protein kinase 14 0.0706 0.0486 0.0813
Onchocerca volvulus 0.029 0.0102 0.0179
Trichomonas vaginalis CAMK family protein kinase 0.0445 0.0245 0.2339
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.0237 0.0053 0.0052
Schistosoma mansoni tyrosine kinase 0.0958 0.0719 0.2243
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0613 0.04 0.3764
Schistosoma mansoni tyrosine kinase 0.0989 0.0747 0.2331
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0237 0.0053 0.0432
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0264 0.0077 0.0076
Echinococcus multilocularis basement membrane specific heparan sulfate 0.036 0.0166 0.0262
Schistosoma mansoni serine/threonine protein kinase 0.0598 0.0386 0.1203
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0517 0.0311 0.2961
Echinococcus granulosus serine:threonine protein kinase 3 0.17 0.1404 0.4358
Trichomonas vaginalis AGC family protein kinase 0.0582 0.0372 0.3543
Schistosoma mansoni serine/threonine protein kinase 0.032 0.013 0.0401
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0978 0.0737 0.0736
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.028 0.0092 0.0091
Echinococcus multilocularis mitogen activated protein kinase 3 0.0206 0.0025 0.0018
Loa Loa (eye worm) TK/ROR protein kinase 0.0241 0.0057 0.0056
Giardia lamblia Kinase, CMGC GSK 0.1252 0.099 0.9423
Loa Loa (eye worm) hypothetical protein 0.0197 0.0016 0.0015
Giardia lamblia Kinase, CDC7 0.1119 0.0868 0.8229
Echinococcus granulosus tyrosine protein kinase Fyn 0.0534 0.0327 0.0982
Giardia lamblia Kinase, CMGC GSK 0.1252 0.099 0.9423
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0816 0.0588 0.5569
Trichomonas vaginalis protein kinase atmrk1, putative 0.0237 0.0053 0.0506
Schistosoma mansoni protein kinase 0.0302 0.0113 0.035
Trichomonas vaginalis AGC family protein kinase 0.0188 0.0008 0.0077
Leishmania major protein kinase A catalytic subunit isoform 1 0.1146 0.0892 0.8492
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.2992 0.2598 0.8102
Echinococcus multilocularis expressed conserved protein 0.0251 0.0066 0.0089
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0816 0.0588 0.1833
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0289 0.0101 0.0149
Trichomonas vaginalis CMGC family protein kinase 0.0206 0.0025 0.0234
Schistosoma mansoni tyrosine kinase 0.0855 0.0623 0.1944
Schistosoma mansoni serine/threonine protein kinase 0.0206 0.0024 0.0072
Echinococcus granulosus ephrin type A receptor 4 A 0.0213 0.0031 0.0052
Schistosoma mansoni serine/threonine-protein kinase 0.0297 0.0108 0.0335
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0241 0.0057 0.0133
Echinococcus granulosus fibroblast growth factor receptor 4 0.0671 0.0454 0.1379
Schistosoma mansoni serine/threonine protein kinase 0.0454 0.0253 0.0787
Entamoeba histolytica protein kinase, putative 0.0188 0.0008 0.0015
Echinococcus granulosus cyclin dependent kinase 19 0.0968 0.0728 0.2239
Schistosoma mansoni vesicular amine transporter 0.036 0.0166 0.0516
Entamoeba histolytica protein kinase, putative 0.0335 0.0143 0.0531
Echinococcus granulosus casein kinase I alpha 0.0488 0.0285 0.0849
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0671 0.0454 0.4281
Echinococcus granulosus serine threonine protein kinase nrc 0.027 0.0084 0.0218
Plasmodium vivax serine/threonine protein kinase, putative 0.0206 0.0024 0.0153
Brugia malayi Sex muscle abnormal protein 5 0.0199 0.0018 0.0017
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0255 0.0069 0.0588
Echinococcus multilocularis cyclin dependent kinase 1 0.1217 0.0958 0.1626
Schistosoma mansoni serine/threonine protein kinase 0.037 0.0176 0.0546
Schistosoma mansoni serine/threonine protein kinase 0.0488 0.0285 0.0887
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.1146 0.0892 0.8492
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.037 0.0176 0.0175
Onchocerca volvulus 0.0546 0.0338 0.0929
Brugia malayi Serine/threonine-protein kinase SULU 0.0978 0.0737 0.0736
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0454 0.0254 0.0253
Echinococcus multilocularis casein kinase i 0.0488 0.0285 0.0467
Echinococcus multilocularis death associated protein kinase 1 0.6478 0.5818 1
Loa Loa (eye worm) hypothetical protein 0.0816 0.0588 0.0587
Trypanosoma cruzi casein kinase II, putative 0.0221 0.0038 0.0352
Schistosoma mansoni serine/threonine protein kinase 0.0447 0.0247 0.0768
Entamoeba histolytica serine/threonine protein kinase, putative 0.0289 0.0101 0.0369
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0199 0.0018 0.0017
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0206 0.0025 0.0158
Plasmodium vivax casein kinase 1, putative 0.0488 0.0285 0.2658
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0671 0.0454 0.432
Loa Loa (eye worm) hypothetical protein 0.0247 0.0062 0.0061
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.0101 0.096
Trichomonas vaginalis CAMK family protein kinase 0.037 0.0176 0.1675
Brugia malayi Protein kinase domain containing protein 0.1217 0.0958 0.0957
Trichomonas vaginalis AGC family protein kinase 0.0237 0.0053 0.0506
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.0101 0.096
Brugia malayi Serine/threonine-protein kinase Pim-3 0.2992 0.2598 0.2597
Schistosoma mansoni Neurotrimin precursor (hNT) 0.036 0.0166 0.0516
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0454 0.0253 0.0951
Entamoeba histolytica protein kinase domain containing protein 0.0319 0.0128 0.0474
Echinococcus granulosus TGF beta receptor type 1 0.0408 0.0211 0.0618
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.1252 0.099 0.3089
Onchocerca volvulus 0.029 0.0102 0.0179
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1912 0.16 0.1599
Schistosoma mansoni serine/threonine protein kinase 0.1146 0.0892 0.2784
Brugia malayi protein C17H12.11 0.021 0.0028 0.0027
Echinococcus multilocularis casein kinase I delta 0.0488 0.0285 0.0467
Brugia malayi Cam kinase protein 1 0.0454 0.0254 0.0253
Echinococcus multilocularis CDC7 cell division cycle 7 0.1119 0.0868 0.1471
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Toxoplasma gondii histone kinase SNF1, putative 0.0289 0.0101 0.089
Trypanosoma cruzi cdc2-related kinase 3 0.1217 0.0958 0.9128
Loa Loa (eye worm) hypothetical protein 0.0493 0.029 0.0289
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0534 0.0327 0.054
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0206 0.0025 0.0225
Echinococcus granulosus protein kinase C gamma type 0.0483 0.028 0.0834
Schistosoma mansoni serine/threonine protein kinase 0.0251 0.0066 0.0202
Brugia malayi Protein kinase domain containing protein 0.0447 0.0247 0.0246
Onchocerca volvulus Serine\/threonine kinase homolog 0.037 0.0176 0.0414
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Trichomonas vaginalis CMGC family protein kinase 0.0237 0.0053 0.0506
Loa Loa (eye worm) thyroid receptor interactor 0.0626 0.0413 0.0412
Schistosoma mansoni serine/threonine protein kinase 0.0206 0.0024 0.0072
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0871 0.0639 0.0638
Entamoeba histolytica protein kinase , putative 0.0454 0.0253 0.0951
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.1048 0.0802 0.1358
Trichomonas vaginalis CAMK family protein kinase 0.037 0.0176 0.1675
Plasmodium vivax tyrosine kinase-like protein, putative 0.0204 0.0022 0.0137
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0252 0.0067 0.0566
Trichomonas vaginalis STE family protein kinase 0.0671 0.0454 0.4326
Toxoplasma gondii AGC kinase 0.0555 0.0347 0.3255
Plasmodium falciparum NIMA related kinase 1 0.0252 0.0067 0.0566
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0671 0.0454 0.0453
Schistosoma mansoni protein kinase 0.0454 0.0253 0.0787
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0025 0.0235
Schistosoma mansoni tyrosine kinase 0.0534 0.0327 0.1019
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0025 0.0235
Schistosoma mansoni protein kinase 0.0403 0.0206 0.0642
Onchocerca volvulus 0.0688 0.0469 0.1343
Schistosoma mansoni cell adhesion molecule 0.0427 0.0228 0.071
Brugia malayi probable protein kinase 0.2074 0.1749 0.1749
Brugia malayi ephrin receptor 1 precursor 0.0183 0.0003 0.0002
Echinococcus granulosus tyrosine kinase 0.029 0.0102 0.0274
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0454 0.0254 0.0413
Echinococcus granulosus tyrosine protein kinase Src42A 0.0318 0.0128 0.0356
Echinococcus multilocularis NCK adaptor protein 0.0207 0.0025 0.0019
Trichomonas vaginalis AGC family protein kinase 0.0204 0.0023 0.0217
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0363 0.017 0.0488
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0313 0.0123 0.0122
Entamoeba histolytica protein kinase, putative 0.0206 0.0024 0.0076
Brugia malayi Protein kinase domain containing protein 0.0968 0.0728 0.0727
Echinococcus granulosus protein kinase c epsilon type 0.0563 0.0354 0.1066
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.1146 0.0892 0.1513
Brugia malayi Protein kinase domain containing protein 0.029 0.0102 0.0101
Schistosoma mansoni protein kinase 0.0319 0.0128 0.0397
Plasmodium vivax calcium-dependent protein kinase, putative 0.0454 0.0254 0.2359
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0206 0.0025 0.0158
Loa Loa (eye worm) TK/FER protein kinase 0.029 0.0102 0.0101
Trichomonas vaginalis CMGC family protein kinase 0.1252 0.099 0.9436
Brugia malayi Protein kinase domain containing protein 0.0197 0.0016 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Brugia malayi hypothetical protein 0.0377 0.0183 0.0182
Brugia malayi protein unc-22 0.0264 0.0077 0.0076
Schistosoma mansoni tyrosine kinase 0.0339 0.0147 0.0456
Trichomonas vaginalis AGC family protein kinase 0.0492 0.0288 0.2745
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0968 0.0728 0.0727
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0295 0.0106 0.039
Echinococcus granulosus tyrosine protein kinase shark 0.1756 0.1456 0.4522
Loa Loa (eye worm) haspin protein kinase 0.0237 0.0053 0.0052
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0823 0.0594 0.0593
Trichomonas vaginalis AGC family protein kinase 0.0582 0.0372 0.3543
Loa Loa (eye worm) hypothetical protein 0.0816 0.0588 0.0587
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0706 0.0486 0.4624
Trichomonas vaginalis STE family protein kinase 0.0517 0.0311 0.2967
Brugia malayi Protein kinase domain containing protein 0.1036 0.0791 0.079
Entamoeba histolytica protein kinase, putative 0.0324 0.0133 0.0493
Entamoeba histolytica protein kinase, putative 0.0204 0.0023 0.0071
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0025 0.0235
Echinococcus multilocularis 0.1154 0.09 0.1526
Echinococcus multilocularis mitogen activated protein kinase 14 0.0706 0.0486 0.0813
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0316 0.0126 0.0193
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0468 0.0266 0.0789
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0255 0.0069 0.0652
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.1146 0.0892 0.8502
Trichomonas vaginalis CMGC family protein kinase 0.1217 0.0958 0.9128
Echinococcus granulosus Protein kinase C brain isozyme 0.0598 0.0386 0.1167
Echinococcus multilocularis tyrosine protein kinase Blk 0.0468 0.0266 0.0434
Schistosoma mansoni serine/threonine protein kinase 0.0592 0.0381 0.1186
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0319 0.0128 0.1213
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.036 0.0166 0.0516
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0454 0.0253 0.0749
Echinococcus multilocularis serine:threonine protein kinase N2 0.1451 0.1175 0.2
Trypanosoma cruzi aurora B kinase, putative 0.0454 0.0253 0.2404
Plasmodium falciparum calcium-dependent protein kinase 2 0.0454 0.0254 0.2359
Brugia malayi Protein kinase domain containing protein 0.0659 0.0443 0.0442
Giardia lamblia Kinase, CMGC CK2 0.0221 0.0038 0.0134
Schistosoma mansoni protein kinase 0.0316 0.0126 0.039
Brugia malayi Protein kinase domain containing protein 0.0277 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0409 0.0212 0.0211
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0251 0.0066 0.0554
Onchocerca volvulus 0.3338 0.2917 0.9096
Trichomonas vaginalis CMGC family protein kinase 0.0206 0.0025 0.0234
Brugia malayi Furin-like cysteine rich region family protein 0.0855 0.0623 0.0623
Loa Loa (eye worm) CDC7 protein kinase 0.1119 0.0868 0.0867
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0237 0.0053 0.0497
Echinococcus multilocularis mitogen activated protein kinase 11 0.0706 0.0486 0.0813
Loa Loa (eye worm) CAMK/PIM protein kinase 0.2992 0.2598 0.2597
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0534 0.0327 0.054
Schistosoma mansoni serine/threonine protein kinase 0.0206 0.0025 0.0074
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0208 0.0026 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Trypanosoma cruzi polo-like protein kinase, putative 0.037 0.0176 0.1667
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0289 0.0101 0.0952
Echinococcus multilocularis serine:threonine protein kinase 0.0197 0.0016 0.0004
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.1891 0.158 0.2699
Brugia malayi Protein kinase domain containing protein 0.2503 0.2146 0.2145
Plasmodium falciparum glycogen synthase kinase 3 0.1252 0.099 0.9432
Echinococcus granulosus mitogen activated protein kinase 0.0206 0.0025 0.0033
Entamoeba histolytica protein kinase, putative 0.0454 0.0254 0.0954
Echinococcus multilocularis expressed protein 0.0206 0.0024 0.0017
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0671 0.0454 0.0758
Schistosoma mansoni tyrosine kinase 0.0292 0.0104 0.0321
Echinococcus granulosus NCK adaptor protein 0.0199 0.0018 0.0013
Plasmodium falciparum calcium-dependent protein kinase 3 0.0454 0.0254 0.2359
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0409 0.0212 0.062
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0816 0.0588 0.5599
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0816 0.0588 0.0989
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0526 0.032 0.0319
Trichomonas vaginalis CMGC family protein kinase 0.0255 0.0069 0.0661
Entamoeba histolytica p21-activated kinase 0.0343 0.0151 0.056
Trichomonas vaginalis CMGC family protein kinase 0.1252 0.099 0.9436
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0309 0.0119 0.0118
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0671 0.0454 0.0758
Echinococcus granulosus epidermal growth factor receptor 0.0855 0.0623 0.1911
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0488 0.0285 0.0284
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Schistosoma mansoni kinase 0.0386 0.0191 0.0593
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0197 0.0016 0.0015
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0206 0.0024 0.0153
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0517 0.0311 0.1174
Echinococcus granulosus casein kinase I alpha 0.0488 0.0285 0.0849
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0025 0.0235
Loa Loa (eye worm) hypothetical protein 0.0727 0.0505 0.0504
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0188 0.0008 0.0068
Schistosoma mansoni atypical protein kinase C 0.064 0.0425 0.1325
Trichomonas vaginalis CAMK family protein kinase 0.0454 0.0254 0.2418
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0454 0.0254 0.0413
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0671 0.0454 0.0453
Echinococcus multilocularis growth factor receptor bound protein 2 0.0199 0.0018 0.0007
Schistosoma mansoni rap gtpase-activating protein 0.0816 0.0588 0.1833
Echinococcus granulosus serine:threonine protein kinase NLK 0.0237 0.0053 0.0122
Giardia lamblia Aurora kinase 0.0454 0.0253 0.2233
Trichomonas vaginalis AGC family protein kinase 0.0582 0.0372 0.3543
Brugia malayi Protein kinase domain containing protein 0.029 0.0102 0.0101
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0978 0.0737 0.2268
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0704 0.0485 0.1475
Schistosoma mansoni serine/threonine protein kinase 0.0896 0.0661 0.2062
Plasmodium falciparum serine/threonine protein kinase, putative 0.0454 0.0253 0.2352
Brugia malayi Protein kinase domain containing protein 0.0206 0.0024 0.0023
Brugia malayi serine/threonine kinase 12 0.0454 0.0253 0.0252
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0188 0.0008 0.0068
Echinococcus multilocularis casein kinase ii subunit alpha 0.0221 0.0038 0.0041
Onchocerca volvulus 0.0326 0.0136 0.0287
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0356 0.0163 0.0506
Trichomonas vaginalis CMGC family protein kinase 0.0221 0.0038 0.0361
Trichomonas vaginalis STE family protein kinase 0.0316 0.0126 0.12
Echinococcus multilocularis c src tyrosine kinase 0.0356 0.0163 0.0257
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0706 0.0486 0.4587
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0025 0.0235
Echinococcus granulosus serine:threonine protein kinase PLK1 0.037 0.0176 0.0507
Schistosoma mansoni serine/threonine protein kinase 0.0447 0.0247 0.0768
Schistosoma mansoni serine/threonine protein kinase 0.1146 0.0892 0.2784
Loa Loa (eye worm) TK/FER protein kinase 0.029 0.0102 0.0101
Brugia malayi Protein kinase domain containing protein 0.0237 0.0053 0.0052
Entamoeba histolytica protein kinase, putative 0.116 0.0905 0.3443
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.027 0.0084 0.012
Echinococcus multilocularis transfer RNA-Thr 0.0727 0.0505 0.0846
Brugia malayi intracellular kinase 0.1252 0.099 0.0989
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0025 0.0235
Loa Loa (eye worm) IKK protein kinase 0.3338 0.2917 0.2917
Giardia lamblia Kinase, CK1 Casein kinase 0.0488 0.0285 0.2544
Loa Loa (eye worm) TK protein kinase 0.0468 0.0266 0.0265
Schistosoma mansoni serine/threonine protein kinase 0.0603 0.0391 0.1218
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0978 0.0737 0.2267
Schistosoma mansoni serine/threonine protein kinase 0.0272 0.0085 0.0262
Echinococcus multilocularis raf serine:threonine protein kinase 0.0272 0.0085 0.0122
Loa Loa (eye worm) AGC/NDR protein kinase 0.0447 0.0247 0.0246
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0025 0.0235
Giardia lamblia Kinase, STE STE20 0.0316 0.0126 0.0993
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0479 0.0276 0.0275
Loa Loa (eye worm) TK/ABL protein kinase 0.0472 0.027 0.0269
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0316 0.0126 0.0351
Echinococcus multilocularis activin receptor type 0.1577 0.1291 0.22
Entamoeba histolytica PH domain containing protein kinase, putative 0.1173 0.0917 0.3488
Trichomonas vaginalis CMGC family protein kinase 0.1119 0.0868 0.827
Giardia lamblia Kinase, CAMK CAMKL 0.0237 0.0053 0.0283
Trypanosoma brucei protein kinase, putative 0.1252 0.099 0.9432
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.037 0.0176 0.161
Trichomonas vaginalis STE family protein kinase 0.0252 0.0067 0.0639
Echinococcus multilocularis roundabout 2 0.0511 0.0306 0.0503
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0454 0.0253 0.0951
Schistosoma mansoni serine/threonine protein kinase 0.0704 0.0485 0.151
Brugia malayi serine/threonine-protein kinase PAK 7 0.1597 0.1309 0.1308
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0199 0.0018 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0244 0.0059 0.0564
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.3018 0.2622 0.4493
Schistosoma mansoni tyrosine kinase 0.1026 0.0781 0.2437
Trichomonas vaginalis STE family protein kinase 0.0297 0.0108 0.1033
Schistosoma mansoni protein kinase 0.0316 0.0126 0.039
Trichomonas vaginalis CMGC family protein kinase 0.1217 0.0958 0.9128
Schistosoma mansoni protein kinase 0.0319 0.0128 0.0397
Plasmodium falciparum calcium-dependent protein kinase 4 0.0454 0.0254 0.2359
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.1316 0.1049 1
Echinococcus granulosus serine/threonine protein kinase 0.0297 0.0108 0.0296
Giardia lamblia Kinase, CAMK CAMKL 0.0364 0.017 0.1428
Plasmodium vivax unspecified product 0.0221 0.0038 0.0286
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.1047 0.0801 0.08
Echinococcus granulosus serine:threonine protein kinase 0.0197 0.0016 0.0007
Leishmania major protein kinase, putative 0.1316 0.1049 1
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.0101 0.096
Loa Loa (eye worm) TK protein kinase 0.0335 0.0143 0.0142
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0517 0.0311 0.2961
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0206 0.0024 0.0153
Giardia lamblia Kinase, AGC AKT 0.0586 0.0375 0.3426
Trypanosoma brucei protein kinase, putative 0.0319 0.0128 0.1153
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.027 0.0084 0.0726
Echinococcus multilocularis tyrosine kinase 0.029 0.0102 0.0151
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0025 0.0235
Brugia malayi STE20-like kinase MST 0.17 0.1404 0.1403
Trichomonas vaginalis CMGC family protein kinase 0.1119 0.0868 0.827
Entamoeba histolytica cell division protein kinase 2, putative 0.1292 0.1028 0.391
Brugia malayi Homeodomain interacting protein kinase protein 1 0.3018 0.2622 0.2621
Echinococcus granulosus casein kinase I delta 0.0488 0.0285 0.0849
Echinococcus granulosus glycogen synthase kinase 3 beta 0.1252 0.099 0.3061
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0206 0.0024 0.0023
Echinococcus granulosus cyclin dependent kinase 7 0.0896 0.0661 0.203
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0534 0.0327 0.0982
Brugia malayi Protein kinase domain containing protein 0.029 0.0102 0.0101
Brugia malayi map kinase activated protein kinase protein 2 0.0479 0.0276 0.0275
Schistosoma mansoni serine/threonine protein kinase 0.0277 0.009 0.0277
Echinococcus granulosus growth factor receptor bound protein 2 0.0207 0.0025 0.0034
Trypanosoma cruzi Protein kinase B 0.0297 0.0108 0.1024
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.3018 0.2622 0.2621
Loa Loa (eye worm) hypothetical protein 0.0598 0.0387 0.0386
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.1217 0.0958 0.9122
Brugia malayi Variant SH3 domain containing protein 0.0199 0.0018 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0289 0.0101 0.0312
Trichomonas vaginalis AGC family protein kinase 0.0522 0.0317 0.3016
Giardia lamblia Kinase, NEK 0.0252 0.0067 0.0419
Onchocerca volvulus 0.029 0.0102 0.0179
Trypanosoma cruzi NIMA-related kinase, putative 0.0188 0.0008 0.0068
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0823 0.0594 0.0593
Echinococcus granulosus calcium dependent protein kinase 0.0293 0.0104 0.0283
Brugia malayi Stress-activated protein kinase jnk-1 0.1159 0.0904 0.0904
Trichomonas vaginalis STE family protein kinase 0.0316 0.0126 0.12
Schistosoma mansoni serine/threonine protein kinase 0.1217 0.0958 0.2989
Echinococcus granulosus serine:threonine protein kinase 0.0197 0.0016 0.0007
Brugia malayi Temporarily assigned gene name protein 59 0.0816 0.0588 0.0587
Loa Loa (eye worm) hypothetical protein 0.0226 0.0043 0.0042
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0454 0.0254 0.0751
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0509 0.0304 0.0499
Echinococcus multilocularis TGF beta receptor type 1 0.0408 0.0211 0.0339
Echinococcus granulosus neuroglian 0.0444 0.0244 0.0721
Trichomonas vaginalis AGC family protein kinase 0.0188 0.0008 0.0077
Loa Loa (eye worm) AUR protein kinase 0.0454 0.0253 0.0252
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0188 0.0008 0.0068
Echinococcus granulosus cyclin dependent kinase 9 0.0592 0.0381 0.115
Trichomonas vaginalis CMGC family protein kinase 0.0255 0.0069 0.0661
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0025 0.0235
Schistosoma mansoni tyrosine kinase 0.0534 0.0327 0.1019
Echinococcus granulosus tyrosine kinase 0.0468 0.0266 0.0789
Schistosoma mansoni nephrin 0.0461 0.026 0.081
Loa Loa (eye worm) AGC/PKG protein kinase 0.0251 0.0066 0.0065
Echinococcus granulosus beta-adrenergic receptor kinase 0.0206 0.0024 0.0032
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0509 0.0304 0.0909
Echinococcus multilocularis mitogen activated protein kinase 0.0206 0.0025 0.0018
Echinococcus multilocularis cyclin dependent kinase 5 0.1217 0.0958 0.1626
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0204 0.0022 0.0137
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.1146 0.0892 0.2754
Brugia malayi protein kinase C3,putative 0.0349 0.0157 0.0156
Leishmania major protein kinase, putative 0.1316 0.1049 1
Leishmania major serine/threonine kinase-like protein, putative 0.0237 0.0053 0.0432
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Loa Loa (eye worm) hypothetical protein 0.036 0.0166 0.0165
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0316 0.0126 0.0193
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Plasmodium falciparum calcium-dependent protein kinase 5 0.0454 0.0254 0.2359
Loa Loa (eye worm) hypothetical protein 0.1912 0.16 0.1599
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0025 0.0235
Entamoeba histolytica protein kinase, putative 0.0555 0.0347 0.131
Echinococcus granulosus Vam6:Vps39 protein 0.0816 0.0588 0.18
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.1217 0.0958 0.9122
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0454 0.0254 0.0751
Loa Loa (eye worm) hypothetical protein 0.0661 0.0444 0.0443
Schistosoma mansoni serine/threonine protein kinase 0.0978 0.0737 0.2298
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.1316 0.1049 1
Schistosoma mansoni serine/threonine protein kinase 0.0509 0.0304 0.0946
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.1436 0.1161 0.116
Echinococcus multilocularis casein kinase I alpha 0.0488 0.0285 0.0467
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0454 0.0253 0.0951
Loa Loa (eye worm) hypothetical protein 0.036 0.0166 0.0165
Schistosoma mansoni tyrosine kinase 0.1623 0.1333 0.4161
Giardia lamblia Kinase, CMGC DYRK 0.0255 0.0069 0.0442
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0289 0.0101 0.089
Echinococcus granulosus dual specificity 0.0255 0.0069 0.0173
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0488 0.0285 0.0284
Echinococcus granulosus tyrosine protein kinase ABL1 0.0472 0.027 0.0801
Schistosoma mansoni growth factor receptor-bound protein 0.0199 0.0018 0.0054
Trichomonas vaginalis CMGC family protein kinase 0.0221 0.0038 0.0361
Schistosoma mansoni protein kinase 0.1891 0.158 0.4932
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1252 0.099 0.0989
Schistosoma mansoni tyrosine kinase 0.0515 0.031 0.0965
Loa Loa (eye worm) TK/EPH protein kinase 0.0228 0.0045 0.0044
Loa Loa (eye worm) AUR protein kinase 0.0454 0.0253 0.0252
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Echinococcus multilocularis c Jun NH2 terminal kinase 0.1159 0.0904 0.1534
Entamoeba histolytica protein kinase, putative 0.0324 0.0133 0.0493
Brugia malayi Protein kinase domain containing protein 0.0659 0.0443 0.0442
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0289 0.0101 0.089
Brugia malayi Protein kinase domain containing protein 0.0302 0.0113 0.0112
Echinococcus multilocularis 0.0211 0.0029 0.0026
Loa Loa (eye worm) TK/FER protein kinase 0.0404 0.0207 0.0206
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0376 0.0182 0.0525
Echinococcus granulosus rho-associated protein kinase 1 0.3648 0.3203 1
Schistosoma mansoni hypothetical protein 0.0311 0.0122 0.0377
Loa Loa (eye worm) hypothetical protein 0.0659 0.0443 0.0442
Brugia malayi Protein kinase c protein 2 0.0313 0.0123 0.0122
Echinococcus granulosus mitogen activated protein kinase 11 0.0706 0.0486 0.1479
Echinococcus multilocularis calcium activated potassium channel 0.0473 0.0271 0.0443
Entamoeba histolytica hypothetical protein 0.0188 0.0008 0.0015
Echinococcus granulosus mitogen activated protein kinase 3 0.0206 0.0025 0.0033
Loa Loa (eye worm) TK protein kinase 0.0271 0.0084 0.0083
Onchocerca volvulus 0.0598 0.0387 0.1082
Echinococcus granulosus TGF-beta receptor type-1 0.0408 0.0211 0.0618
Echinococcus multilocularis ephrin type A receptor 4 A 0.0213 0.0031 0.0029
Trichomonas vaginalis CMGC family protein kinase 0.0255 0.0069 0.0661
Echinococcus multilocularis dual specificity 0.0255 0.0069 0.0095
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0372 0.0178 0.0177
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.037 0.0176 0.0279
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0735 0.0513 0.086
Trichomonas vaginalis CMGC family protein kinase 0.0221 0.0038 0.0361
Loa Loa (eye worm) TK/FER protein kinase 0.029 0.0102 0.0101
Schistosoma mansoni protein kinase C mu 0.0823 0.0594 0.1851
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0509 0.0304 0.0499
Trichomonas vaginalis CAMK family protein kinase 0.0735 0.0513 0.489
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.0101 0.096
Leishmania major protein kinase, putative 0.0454 0.0254 0.2359
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0316 0.0126 0.0193
Loa Loa (eye worm) hypothetical protein 0.0546 0.0338 0.0337
Echinococcus granulosus casein kinase I alpha 0.0488 0.0285 0.0849
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0534 0.0327 0.0982
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0454 0.0254 0.2359
Schistosoma mansoni serine/threonine protein kinase 0.0289 0.0101 0.0312
Schistosoma mansoni hypothetical protein 0.0311 0.0122 0.0377
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.1252 0.099 0.1682
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0237 0.0053 0.0497
Trichomonas vaginalis STE family protein kinase 0.0671 0.0454 0.4326
Brugia malayi hypothetical protein 0.0816 0.0588 0.0587
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Schistosoma mansoni nck2/grb4 0.0199 0.0018 0.0054
Trypanosoma cruzi casein kinase, putative 0.0488 0.0285 0.2708
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.1146 0.0892 0.8492
Brugia malayi Protein kinase domain containing protein 0.0372 0.0178 0.0177
Loa Loa (eye worm) hypothetical protein 0.0311 0.0122 0.0121
Echinococcus multilocularis N chimaerin 0.0248 0.0063 0.0084
Entamoeba histolytica PH domain containing protein kinase, putative 0.1173 0.0917 0.3488
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0206 0.0025 0.0235
Loa Loa (eye worm) hypothetical protein 0.0219 0.0037 0.0036
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0181 0.0001 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Trichomonas vaginalis CMGC family protein kinase 0.0221 0.0038 0.0361
Entamoeba histolytica protein kinase, putative 0.0454 0.0253 0.0951
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.17 0.1404 0.1403
Trichomonas vaginalis serine/threonine kinase, putative 0.0237 0.0053 0.0506
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.2992 0.2598 0.8084
Entamoeba histolytica PH domain containing protein kinase, putative 0.0188 0.0008 0.0015
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0204 0.0023 0.0027
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.116 0.0905 0.8617
Echinococcus multilocularis insulin receptor 0.0958 0.0719 0.1215
Echinococcus multilocularis cyclin dependent kinase 9 0.0667 0.045 0.0752
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0534 0.0327 0.054
Echinococcus granulosus tyrosine protein kinase Srms 0.0647 0.0432 0.1311
Loa Loa (eye worm) hypothetical protein 0.0289 0.0101 0.01
Echinococcus multilocularis tyrosine protein kinase HCK 0.0335 0.0143 0.0222
Echinococcus multilocularis Immunoglobulin 0.036 0.0166 0.0262
Echinococcus multilocularis beta adrenergic receptor kinase 0.0206 0.0024 0.0017
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0454 0.0254 0.0751
Entamoeba histolytica protein kinase, putative 0.0456 0.0255 0.0958
Echinococcus multilocularis rho associated protein kinase 0.3648 0.3203 0.5495
Brugia malayi p70 ribosomal S6 kinase beta 0.0555 0.0347 0.0346
Schistosoma mansoni serine/threonine protein kinase 0.2992 0.2598 0.811
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0517 0.0311 0.2913
Trypanosoma cruzi polo-like protein kinase, putative 0.037 0.0176 0.1667
Echinococcus granulosus serine:threonine protein kinase mig 15 0.1912 0.16 0.4973
Loa Loa (eye worm) TK/EGFR protein kinase 0.0855 0.0623 0.0623
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.1146 0.0892 0.0891
Onchocerca volvulus 0.1252 0.099 0.2993
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0188 0.0008 0.0068
Echinococcus granulosus titin 0.0264 0.0077 0.0199
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0204 0.0022 0.0137
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.1136 0.0883 0.1497
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0363 0.017 0.0169
Giardia lamblia Kinase, CMGC CLK 0.1316 0.1049 1
Echinococcus multilocularis dual specificity 0.0255 0.0069 0.0095
Schistosoma mansoni tyrosine kinase 0.029 0.0102 0.0316
Echinococcus granulosus cGMP dependent protein kinase 0.0251 0.0066 0.0162
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0408 0.0211 0.0339
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0708 0.0488 0.0487
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0297 0.0108 0.1024
Echinococcus granulosus tyrosine protein kinase Src64B 0.0534 0.0327 0.0982
Giardia lamblia Kinase, CMGC MAPK 0.0206 0.0025 0.0005
Entamoeba histolytica protein kinase, putative 0.0195 0.0014 0.0038
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.1159 0.0904 0.0904
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.1146 0.0892 0.8492
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.1461 0.1184 0.2015
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0289 0.0101 0.01
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0706 0.0486 0.0485
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0706 0.0486 0.4624
Loa Loa (eye worm) hypothetical protein 0.0377 0.0183 0.0182
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0364 0.017 0.1559
Trichomonas vaginalis CMGC family protein kinase 0.1316 0.1049 1
Trichomonas vaginalis AGC family protein kinase 0.0237 0.0053 0.0506
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.0101 0.096
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0206 0.0025 0.0024
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.1146 0.0892 0.1513
Brugia malayi Immunoglobulin I-set domain containing protein 0.0264 0.0077 0.0076
Plasmodium vivax protein kinase Crk2 0.1217 0.0958 0.9122
Brugia malayi Protein kinase domain containing protein 0.0582 0.0372 0.0371
Echinococcus granulosus tyrosine protein kinase HCK 0.0335 0.0143 0.0404
Echinococcus granulosus dual specificity 0.0255 0.0069 0.0173
Giardia lamblia Kinase, NEK 0.0252 0.0067 0.0419
Trypanosoma cruzi cdc2-related kinase 3 0.1217 0.0958 0.9128
Schistosoma mansoni serine/threonine protein kinase 0.1136 0.0883 0.2754
Echinococcus multilocularis twitchin 0.0246 0.0061 0.0081
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0255 0.0069 0.0588
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0255 0.0069 0.0068
Trypanosoma brucei polo-like protein kinase 0.037 0.0176 0.161
Brugia malayi Protein kinase domain containing protein 0.2329 0.1985 0.1985
Trichomonas vaginalis CMGC family protein kinase 0.0221 0.0038 0.0361
Entamoeba histolytica protein kinase domain containing protein 0.0592 0.0381 0.1439
Schistosoma mansoni tyrosine kinase 0.0356 0.0163 0.0506
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0204 0.0023 0.0022
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Entamoeba histolytica PH domain containing protein kinase, putative 0.0188 0.0008 0.0015
Echinococcus granulosus tyrosine protein kinase Src42A 0.0534 0.0327 0.0982
Loa Loa (eye worm) gastrulation defective protein 1 0.0806 0.0579 0.0578
Plasmodium falciparum cGMP-dependent protein kinase 0.0251 0.0066 0.0554
Brugia malayi Doublecortin family protein 0.0265 0.0079 0.0078
Onchocerca volvulus Tyrosine kinase homolog 0.1587 0.13 0.3974
Trypanosoma brucei cdc2-related kinase 1 0.1217 0.0958 0.9122
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0025 0.0235
Loa Loa (eye worm) hypothetical protein 0.1055 0.0809 0.0808
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.1146 0.0892 0.2754
Schistosoma mansoni tyrosine kinase 0.0356 0.0163 0.0506
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Echinococcus multilocularis protein kinase c iota type 0.0635 0.042 0.07
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0221 0.0038 0.0286
Giardia lamblia Kinase, STE STE20 0.0671 0.0454 0.4192
Schistosoma mansoni serine/threonine protein kinase 0.0598 0.0386 0.1203
Trichomonas vaginalis CK1 family protein kinase 0.0488 0.0285 0.2715
Toxoplasma gondii CMGC kinase, CK2 family 0.0221 0.0038 0.0286
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0447 0.0247 0.073
Entamoeba histolytica protein kinase domain containing protein 0.116 0.0905 0.3443
Trichomonas vaginalis CMGC family protein kinase 0.0237 0.0053 0.0506
Loa Loa (eye worm) hypothetical protein 0.0376 0.0182 0.0181
Onchocerca volvulus 0.3486 0.3054 0.9527
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0567 0.0357 0.1077
Loa Loa (eye worm) hypothetical protein 0.1045 0.0799 0.0799
Entamoeba histolytica protein kinase, putative 0.0188 0.0008 0.0015
Schistosoma mansoni tyrosine kinase 0.0671 0.0454 0.1414
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0984 0.0743 0.2286
Brugia malayi putative serine/threonine kinase SADA gamma 0.0289 0.0101 0.01
Brugia malayi serine/threonine-protein kinase plk-2 0.037 0.0176 0.0175
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0255 0.0069 0.0588
Schistosoma mansoni tyrosine kinase 0.0672 0.0455 0.1417
Schistosoma mansoni protein kinase 0.0408 0.0211 0.0656
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0454 0.0254 0.2359
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0534 0.0327 0.054
Brugia malayi bone morphogenetic protein type 1 receptor 0.0403 0.0206 0.0205
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.2503 0.2146 0.2145
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0563 0.0354 0.0353
Brugia malayi serine/threonine-protein kinase 6 0.0454 0.0253 0.0252
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0816 0.0588 0.18
Onchocerca volvulus 0.0661 0.0444 0.1265
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.1316 0.1049 1
Echinococcus granulosus NDR protein kinase 0.0447 0.0247 0.073
Trichomonas vaginalis CK1 family protein kinase 0.0488 0.0285 0.2715
Loa Loa (eye worm) AGC/PKN protein kinase 0.1451 0.1175 0.1174
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0195 0.0014 0.0000038535
Loa Loa (eye worm) protein kinase domain-containing protein 0.032 0.013 0.0129
Loa Loa (eye worm) hypothetical protein 0.0199 0.0018 0.0017
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0025 0.0235
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Onchocerca volvulus Serine\/threonine kinase homolog 0.0277 0.009 0.0142
Loa Loa (eye worm) hypothetical protein 0.0998 0.0756 0.0755
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.1146 0.0892 0.8492
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0603 0.0391 0.039
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0221 0.0038 0.0037
Echinococcus granulosus twitchin 0.0606 0.0393 0.1189
Schistosoma mansoni serine/threonine protein kinase 0.0479 0.0276 0.086
Loa Loa (eye worm) hypothetical protein 0.0816 0.0588 0.0587
Entamoeba histolytica protein kinase domain containing protein 0.0255 0.0069 0.0249
Schistosoma mansoni tyrosine kinase 0.0958 0.0719 0.2243
Plasmodium falciparum calcium-dependent protein kinase 1 0.0454 0.0254 0.2359
Brugia malayi RhoGAP domain containing protein 0.0248 0.0063 0.0062
Echinococcus multilocularis myosin iiia 0.0517 0.0311 0.0512
Echinococcus granulosus c-Jun N-terminal kinases 0.1159 0.0904 0.2792
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0251 0.0066 0.0089
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0025 0.0235
Schistosoma mansoni serine/threonine protein kinase 0.0473 0.0271 0.0843
Trichomonas vaginalis STE family protein kinase 0.0316 0.0126 0.12
Loa Loa (eye worm) hypothetical protein 0.2026 0.1705 0.1704
Echinococcus granulosus serine:threonine kinase SAD 1 0.0289 0.0101 0.0272
Echinococcus granulosus dual specificity 0.0255 0.0069 0.0173
Trypanosoma cruzi casein kinase, putative 0.0488 0.0285 0.2708
Loa Loa (eye worm) hypothetical protein 0.0998 0.0756 0.0755
Schistosoma mansoni hypothetical protein 0.0816 0.0588 0.1833
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0199 0.0018 0.0054
Brugia malayi casein kinase I 0.0488 0.0285 0.0284
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0237 0.0053 0.0497
Echinococcus multilocularis protein kinase shaggy 0.1252 0.099 0.1682
Leishmania major protein kinase, putative 0.0454 0.0253 0.2352
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.116 0.0905 0.8626
Trichomonas vaginalis CMGC family protein kinase 0.1217 0.0958 0.9128
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0319 0.0128 0.0358
Echinococcus granulosus insulin receptor 0.0958 0.0719 0.2211
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0978 0.0737 0.1246
Trichomonas vaginalis AGC family protein kinase 0.0582 0.0372 0.3543
Entamoeba histolytica protein kinase, putative 0.0255 0.0069 0.0249
Echinococcus multilocularis Immunoglobulin 0.036 0.0166 0.0262
Schistosoma mansoni titin 0.0264 0.0077 0.0239
Schistosoma mansoni tyrosine kinase 0.0376 0.0182 0.0564
Echinococcus granulosus epidermal growth factor receptor 0.0672 0.0455 0.1382
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0454 0.0254 0.0253
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0248 0.0063 0.0193
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.0016 0.0155
Echinococcus multilocularis dual specificity 0.0255 0.0069 0.0095
Echinococcus granulosus tyrosine protein kinase Btk29A 0.1048 0.0802 0.2472
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 1.1006 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0246 0.0061 0.0188
Brugia malayi Protein kinase domain containing protein 0.1047 0.0801 0.08
Onchocerca volvulus 0.029 0.0102 0.0179
Trichomonas vaginalis CAMK family protein kinase 0.0244 0.0059 0.0564
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.2503 0.2146 0.6686
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0206 0.0024 0.0023
Echinococcus multilocularis casein kinase I delta 0.0488 0.0285 0.0467
Echinococcus multilocularis aurora kinase A 0.0454 0.0253 0.0412
Schistosoma mansoni serine/threonine protein kinase 0.0359 0.0165 0.0513
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0188 0.0008 0.0068
Echinococcus multilocularis protein KINase family member (kin 25) 0.0376 0.0182 0.0288
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.1217 0.0958 0.0957
Brugia malayi Variant SH3 domain containing protein 0.0199 0.0018 0.0017
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.1891 0.158 0.4911
Loa Loa (eye worm) hypothetical protein 0.0361 0.0168 0.0167
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.1252 0.099 0.9436
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.1316 0.1049 1
Echinococcus granulosus serine:threonine protein kinase N2 0.1451 0.1175 0.3639
Echinococcus granulosus expressed protein 0.0206 0.0024 0.0031
Entamoeba histolytica hypothetical protein 0.0334 0.0142 0.0527
Schistosoma mansoni protein kinase 0.0221 0.0038 0.0115
Echinococcus granulosus raf serine:threonine protein kinase 0.0272 0.0085 0.0222
Schistosoma mansoni serine/threonine protein kinase 0.0896 0.0661 0.2062
Trichomonas vaginalis STE family protein kinase 0.0671 0.0454 0.4326
Brugia malayi Immunoglobulin I-set domain containing protein 0.0755 0.0532 0.0531
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.1436 0.1161 0.116
Schistosoma mansoni protein kinase 0.0297 0.0108 0.0335
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0871 0.0639 0.1959
Echinococcus granulosus cyclin dependent kinase 9 0.0667 0.045 0.1368
Trypanosoma brucei aurora B kinase 0.0454 0.0253 0.2352
Echinococcus multilocularis epidermal growth factor receptor 0.0855 0.0623 0.105
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Entamoeba histolytica protein kinase, putative 0.0582 0.0372 0.1405
Loa Loa (eye worm) TK/FER protein kinase 0.029 0.0102 0.0101
Schistosoma mansoni serine/threonine protein kinase 0.0454 0.0254 0.0789
Trichomonas vaginalis AGC family protein kinase 0.0252 0.0067 0.0639
Entamoeba histolytica protein kinase domain containing protein 0.1252 0.099 0.3768
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.0101 0.096
Trypanosoma cruzi casein kinase, putative 0.0488 0.0285 0.2708
Echinococcus granulosus homeodomain interacting protein kinase 3 0.3018 0.2622 0.8177
Loa Loa (eye worm) TK/ALK protein kinase 0.2329 0.1985 0.1984
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0559 0.035 0.0349
Onchocerca volvulus 0.1119 0.0868 0.2606
Echinococcus granulosus c src tyrosine kinase 0.0356 0.0163 0.0467
Trypanosoma cruzi cdc2-related kinase 1 0.1217 0.0958 0.9128
Echinococcus granulosus cyclin dependent kinase 1 0.1217 0.0958 0.296
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0896 0.0661 0.066
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0355 0.0162 0.0161
Trichomonas vaginalis AGC family protein kinase 0.0237 0.0053 0.0506
Trichomonas vaginalis CAMK family protein kinase 0.1047 0.0801 0.7631
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.1258 0.0996 0.0995
Entamoeba histolytica hypothetical protein 0.116 0.0905 0.3443
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0447 0.0247 0.073
Echinococcus multilocularis tyrosine protein kinase Srms 0.0468 0.0266 0.0434
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.026 0.0074 0.0188
Trichomonas vaginalis CMGC family protein kinase 0.0255 0.0069 0.0661
Brugia malayi Protein kinase domain containing protein 0.116 0.0905 0.0904
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.0014 0.0041
Onchocerca volvulus 0.029 0.0102 0.0179
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0534 0.0327 0.054
Echinococcus granulosus casein kinase ii subunit alpha 0.0221 0.0038 0.0074
Echinococcus multilocularis serine threonine protein kinase 0.0483 0.028 0.0458
Echinococcus multilocularis casein kinase I alpha 0.0488 0.0285 0.0467
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0326 0.0136 0.1283
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0251 0.0066 0.0089
Schistosoma mansoni serine/threonine protein kinase 0.0871 0.0639 0.1992
Echinococcus multilocularis activated cdc42 kinase 1 0.0727 0.0505 0.0846
Loa Loa (eye worm) TK/INSR protein kinase 0.0958 0.0719 0.0718
Brugia malayi Fes/CIP4 homology domain containing protein 0.0626 0.0413 0.0412
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0517 0.0311 0.1174
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0025 0.0235
Trichomonas vaginalis CMGC family protein kinase 0.0221 0.0038 0.0361
Trichomonas vaginalis G protein-coupled receptor kinase, putative 0.0237 0.0053 0.0506
Trichomonas vaginalis CAMK family protein kinase 0.037 0.0176 0.1675
Loa Loa (eye worm) TK/FER protein kinase 0.029 0.0102 0.0101
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0319 0.0128 0.1153
Giardia lamblia Kinase, AGC PKA 0.027 0.0084 0.0581
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0255 0.0069 0.0068
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0248 0.0063 0.0062
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0372 0.0178 0.0177
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0509 0.0304 0.0909
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.0101 0.096
Echinococcus multilocularis casein kinase I gamma 0.032 0.013 0.0199
Schistosoma mansoni serine/threonine protein kinase 0.1217 0.0958 0.2989
Schistosoma mansoni tyrosine kinase 0.0515 0.031 0.0965
Brugia malayi MAP kinase sur-1 0.0206 0.0025 0.0024
Entamoeba histolytica protein kinase, putative 0.0316 0.0126 0.0465
Giardia lamblia Kinase, CMGC CDK 0.1217 0.0958 0.9108
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.116 0.0905 0.0904
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.027 0.0084 0.0218
Trichomonas vaginalis AGC family protein kinase 0.0465 0.0263 0.251
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.116 0.0905 0.8617
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Echinococcus granulosus tyrosine protein kinase Fyn 0.0534 0.0327 0.0982
Loa Loa (eye worm) AGC/PKA protein kinase 0.1146 0.0892 0.0891
Echinococcus multilocularis cyclin dependent kinase 7 0.0896 0.0661 0.1115
Schistosoma mansoni protein kinase 0.0488 0.0285 0.0887
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0567 0.0357 0.0592
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0603 0.0391 0.039
Schistosoma mansoni serine/threonine protein kinase 0.0289 0.0101 0.0312
Echinococcus multilocularis protein kinase c epsilon type 0.0563 0.0354 0.0586
Trypanosoma brucei Mitogen-activated protein kinase 10, putative 0.0237 0.0053 0.0432
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0659 0.0443 0.0442
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0671 0.0454 0.4281
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.027 0.0084 0.0726
Schistosoma mansoni protein kinase 0.1891 0.158 0.4932
Entamoeba histolytica protein kinase domain containing protein 0.0454 0.0253 0.0951
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1252 0.099 0.0989
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0534 0.0327 0.054
Loa Loa (eye worm) CMGC/CLK protein kinase 0.1316 0.1049 0.1049
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0978 0.0737 0.1246
Brugia malayi cell division control protein 2 homolog 0.1217 0.0958 0.0957
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0198 0.0017 0.0016
Loa Loa (eye worm) TK/FER protein kinase 0.029 0.0102 0.0101
Schistosoma mansoni serine/threonine protein kinase 0.0289 0.0101 0.0312
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0671 0.0454 0.1379
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0555 0.0347 0.0346
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0318 0.0128 0.0196
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.0101 0.096
Onchocerca volvulus 0.029 0.0102 0.0179
Echinococcus multilocularis PAK box P21 Rho binding 0.0297 0.0108 0.0162
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.0101 0.096
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.0101 0.096
Schistosoma mansoni serine/threonine protein kinase 0.3648 0.3203 1
Entamoeba histolytica protein kinase domain containing protein 0.1252 0.099 0.3768
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0586 0.0375 0.0374
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0289 0.0101 0.0952
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Echinococcus multilocularis serine:threonine protein kinase NLK 0.0237 0.0053 0.0067
Trichomonas vaginalis CAMK family protein kinase 0.0735 0.0513 0.489
Brugia malayi Protein kinase domain containing protein 0.0187 0.0007 0.0006
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Brugia malayi Protein kinase domain containing protein 0.0529 0.0323 0.0322
Brugia malayi SH2 domain containing protein 0.0404 0.0207 0.0206
Trichomonas vaginalis CAMK family protein kinase 0.037 0.0176 0.1675
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0289 0.0101 0.089
Schistosoma mansoni serine/threonine protein kinase 0.0255 0.0069 0.0213
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0206 0.0025 0.0225
Brugia malayi Tyrosine-protein kinase abl-1 0.0426 0.0227 0.0226
Loa Loa (eye worm) TK/FAK protein kinase 0.1036 0.0791 0.079
Schistosoma mansoni growth factor receptor-bound protein 0.0207 0.0025 0.0075
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.1217 0.0958 0.0957
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.1146 0.0892 0.2754
Entamoeba histolytica casein kinase 1, putative 0.0488 0.0285 0.1073
Toxoplasma gondii casein kinase I 0.0488 0.0285 0.2658
Giardia lamblia Kinase, CAMK CAMKL 0.0364 0.017 0.1428
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Echinococcus multilocularis dual specificity 0.116 0.0905 0.1536
Loa Loa (eye worm) AUR protein kinase 0.0454 0.0253 0.0252
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0319 0.0128 0.1153
Loa Loa (eye worm) hypothetical protein 0.0454 0.0254 0.0253
Toxoplasma gondii AGC kinase 0.1146 0.0892 0.8492
Echinococcus multilocularis rac serine:threonine kinase 0.0297 0.0108 0.0162
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0488 0.0285 0.2708
Entamoeba histolytica protein kinase, putative 0.0295 0.0106 0.039
Echinococcus granulosus protein kinase 0.1258 0.0996 0.3078
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0704 0.0485 0.0484
Echinococcus granulosus casein kinase i 0.0488 0.0285 0.0849
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0468 0.0266 0.0434
Schistosoma mansoni tyrosine kinase 0.1756 0.1456 0.4544
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.1217 0.0958 0.9122
Entamoeba histolytica serine/threonine protein kinase, putative 0.037 0.0176 0.0656
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.116 0.0905 0.8626
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0454 0.0254 0.2359
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.1252 0.099 0.9432
Echinococcus granulosus protein kinase c iota type 0.0635 0.042 0.1274
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0302 0.0113 0.0112
Echinococcus multilocularis serine:threonine protein kinase 0.0197 0.0016 0.0004
Echinococcus granulosus dual specificity mitogen activated protein 0.0671 0.0454 0.1379
Entamoeba histolytica protein kinase, putative 0.0297 0.0108 0.0398
Brugia malayi SRC-1 0.0534 0.0327 0.0326
Loa Loa (eye worm) CAMK protein kinase 0.0264 0.0077 0.0076
Leishmania major casein kinase, putative 0.0488 0.0285 0.2658
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0534 0.0327 0.054
Echinococcus granulosus casein kinase I delta 0.0488 0.0285 0.0849
Trypanosoma cruzi casein kinase, putative 0.0488 0.0285 0.2708
Echinococcus granulosus titin 0.0264 0.0077 0.0199
Echinococcus granulosus Immunoglobulin 0.036 0.0166 0.0477
Loa Loa (eye worm) hypothetical protein 0.0713 0.0493 0.0492
Entamoeba histolytica protein kinase, putative 0.0454 0.0253 0.0951
Schistosoma mansoni tyrosine kinase 0.0672 0.0455 0.1417
Trichomonas vaginalis AGC family protein kinase 0.0454 0.0253 0.2411
Brugia malayi Protein kinase domain containing protein 0.0465 0.0263 0.0262
Trypanosoma brucei casein kinase I, isoform 2 0.0488 0.0285 0.2658
Entamoeba histolytica PH domain containing protein kinase, putative 0.0297 0.0108 0.0398
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0248 0.0063 0.0153
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0277 0.009 0.0237
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.026 0.0074 0.0103
Echinococcus multilocularis dual specificity mitogen activated protein 0.0671 0.0454 0.0758
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0363 0.017 0.0268
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.1146 0.0892 0.8492
Echinococcus granulosus serine:threonine protein kinase N2 0.1004 0.0762 0.2344
Brugia malayi Protein kinase domain containing protein 0.2992 0.2598 0.2597
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0454 0.0254 0.2359
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Brugia malayi Protein kinase domain containing protein 0.0381 0.0186 0.0185
Trichomonas vaginalis AGC family protein kinase 0.0454 0.0253 0.2411
Giardia lamblia Kinase, AGC PKA 0.1146 0.0892 0.8468
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0454 0.0254 0.2359
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0454 0.0254 0.0413
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0816 0.0588 0.5599
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.0237 0.0053 0.0067
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0206 0.0025 0.0225
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.1217 0.0958 0.296
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0465 0.0263 0.0262
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0454 0.0254 0.2359
Echinococcus granulosus activin receptor type 0.1577 0.1291 0.4003
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0976 0.0736 0.2263
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0479 0.0276 0.0452
Loa Loa (eye worm) CAMK/PIM protein kinase 0.2992 0.2598 0.2597
Echinococcus multilocularis protein tyrosine kinase 0.1026 0.0781 0.1322
Loa Loa (eye worm) hypothetical protein 0.0405 0.0208 0.0207
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.1146 0.0892 0.8492
Schistosoma mansoni serine/threonine kinase 0.0447 0.0247 0.0768
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Trichomonas vaginalis CMGC family protein kinase 0.0206 0.0025 0.0234
Brugia malayi Cell division protein kinase 2 0.0237 0.0053 0.0052
Entamoeba histolytica PH domain containing protein kinase, putative 0.0297 0.0108 0.0398
Echinococcus granulosus aurora kinase A 0.0454 0.0253 0.0749
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0454 0.0254 0.2359
Schistosoma mansoni protein kinase 0.0671 0.0454 0.1414
Echinococcus granulosus N chimaerin 0.0248 0.0063 0.0153
Echinococcus granulosus protein kinase shaggy 0.1252 0.099 0.3061
Trichomonas vaginalis CMGC family protein kinase 0.0237 0.0053 0.0506
Brugia malayi Protein kinase domain containing protein 0.0526 0.032 0.0319
Leishmania major casein kinase II, putative 0.0221 0.0038 0.0286
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0534 0.0327 0.054
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Plasmodium falciparum MO15-related protein kinase 0.0237 0.0053 0.0432
Schistosoma mansoni serine/threonine kinase 0.1122 0.087 0.2715
Loa Loa (eye worm) hypothetical protein 0.0546 0.0338 0.0337
Toxoplasma gondii AGC kinase 0.1146 0.0892 0.8492
Brugia malayi Protein kinase domain containing protein 0.0727 0.0505 0.0504
Loa Loa (eye worm) hypothetical protein 0.0372 0.0178 0.0177
Schistosoma mansoni serine/threonine protein kinase 0.1159 0.0904 0.2821
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Loa Loa (eye worm) hypothetical protein 0.0377 0.0183 0.0182
Toxoplasma gondii aurora kinase 0.0454 0.0253 0.2352
Brugia malayi Protein kinase domain containing protein 0.1316 0.1049 0.1049
Brugia malayi Protein kinase domain containing protein 0.029 0.0102 0.0101
Loa Loa (eye worm) TK protein kinase 0.0755 0.0532 0.0531
Brugia malayi hypothetical protein 0.0978 0.0737 0.0736
Onchocerca volvulus 0.1346 0.1077 0.3269
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0204 0.0023 0.0015
Echinococcus multilocularis mitogen activated protein kinase 11 0.0706 0.0486 0.0813
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0403 0.0206 0.0205
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0447 0.0247 0.0401
Schistosoma mansoni serine/threonine protein kinase 0.0309 0.0119 0.037
Trichomonas vaginalis AGC family protein kinase 0.0188 0.0008 0.0077
Echinococcus granulosus defective proboscis extension response 0.036 0.0166 0.0477
Echinococcus granulosus cyclin dependent kinase 5 0.1217 0.0958 0.296
Echinococcus multilocularis casein kinase I alpha 0.0488 0.0285 0.0467
Schistosoma mansoni serine/threonine protein kinase 0.0473 0.0271 0.0843
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0025 0.0235
Echinococcus multilocularis hypothetical protein 0.0311 0.0122 0.0185
Plasmodium vivax serine/threonine kinase-1, putative 0.1316 0.1049 1
Loa Loa (eye worm) hypothetical protein 0.0377 0.0183 0.0182
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0206 0.0024 0.0153
Brugia malayi Protein kinase domain containing protein 0.3338 0.2917 0.2917
Echinococcus granulosus tyrosine protein kinase Fyn 0.0534 0.0327 0.0982
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0479 0.0276 0.0822
Brugia malayi protein kinase C II. 0.0563 0.0354 0.0353
Schistosoma mansoni protein kinase 0.2074 0.1749 0.546
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0816 0.0588 0.1833
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Brugia malayi Protein kinase domain containing protein 0.1119 0.0868 0.0867
Schistosoma mansoni serine/threonine protein kinase 0.1316 0.1049 0.3274
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0206 0.0024 0.022
Echinococcus multilocularis 0.1258 0.0996 0.1691
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.1461 0.1184 0.3668
Loa Loa (eye worm) hypothetical protein 0.1154 0.09 0.0899
Echinococcus multilocularis tyrosine protein kinase shark 0.1756 0.1456 0.2485
Schistosoma mansoni serine/threonine protein kinase 0.116 0.0905 0.2824
Echinococcus granulosus cGMP dependent protein kinase 1 0.0251 0.0066 0.0162
Schistosoma mansoni serine/threonine protein kinase 0.0264 0.0077 0.0239
Trichomonas vaginalis CMGC family protein kinase 0.0255 0.0069 0.0661
Echinococcus granulosus CDC7 cell division cycle 7 0.1119 0.0868 0.2677
Onchocerca volvulus 0.0488 0.0285 0.076
Brugia malayi Hr1 repeat family protein 0.1451 0.1175 0.1174
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0488 0.0285 0.0284
Loa Loa (eye worm) hypothetical protein 0.021 0.0028 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0206 0.0024 0.0072
Brugia malayi casein kinase 1, delta 0.0488 0.0285 0.0284
Brugia malayi cyclin-dependent kinase 9 0.0592 0.0381 0.038
Echinococcus multilocularis cyclin dependent kinase 0.1217 0.0958 0.1626
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0559 0.035 0.1054
Trypanosoma brucei SNF1-related protein kinases, putative 0.0289 0.0101 0.089
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.0101 0.096
Echinococcus multilocularis titin 0.0264 0.0077 0.0109
Trichomonas vaginalis CAMK family protein kinase 0.037 0.0176 0.1675
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.1146 0.0892 0.8502
Schistosoma mansoni ephrin receptor 0.0213 0.0031 0.0093
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0277 0.009 0.0089
Trypanosoma cruzi rac serine-threonine kinase, putative 0.027 0.0084 0.0789
Echinococcus multilocularis cyclin dependent kinase 9 0.0592 0.0381 0.0632
Onchocerca volvulus 0.0264 0.0077 0.0103
Plasmodium falciparum serine/threonine protein kinase KIN 0.0289 0.0101 0.089
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0188 0.0008 0.0068
Schistosoma mansoni serine/threonine protein kinase 0.1316 0.1049 0.3274
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.1316 0.1049 1
Trichomonas vaginalis AGC family protein kinase 0.0454 0.0253 0.2411
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.1316 0.1049 1
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.1597 0.1309 0.1308
Schistosoma mansoni serine/threonine protein kinase 0.1136 0.0883 0.2754
Entamoeba histolytica protein kinase, putative 0.0195 0.0014 0.0038
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0706 0.0486 0.4587
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0559 0.035 0.0349
Trichomonas vaginalis CMGC family protein kinase 0.0255 0.0069 0.0661
Trypanosoma brucei Casein kinase II 0.0221 0.0038 0.0286
Entamoeba histolytica protein kinase, putative 0.0447 0.0247 0.0927
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0248 0.0063 0.0193
Trichomonas vaginalis AGC family protein kinase 0.0237 0.0053 0.0506
Entamoeba histolytica casein kinase, putative 0.0221 0.0038 0.0129
Schistosoma mansoni protein kinase 0.0319 0.0128 0.0397
Echinococcus granulosus Cell division cycle 2 protein kinase 0.0237 0.0053 0.0122
Schistosoma mansoni serine/threonine protein kinase 0.1119 0.0868 0.2707
Brugia malayi C1-like domain containing protein 0.0823 0.0594 0.0593
Brugia malayi hypothetical protein 0.021 0.0028 0.0027
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0025 0.0235
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Plasmodium falciparum serine/threonine protein kinase 0.0206 0.0024 0.0153
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.1146 0.0892 0.1513
Schistosoma mansoni protein kinase 0.1258 0.0996 0.3106
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0454 0.0253 0.0412
Schistosoma mansoni serine/threonine protein kinase 0.1687 0.1392 0.4345
Brugia malayi protein-tyrosine kinase 0.0468 0.0266 0.0265
Brugia malayi Immunoglobulin I-set domain containing protein 0.0208 0.0026 0.0025
Leishmania major mitogen-activated protein kinase, putative,map kinase-like protein 0.0237 0.0053 0.0432
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Giardia lamblia Kinase, PLK 0.037 0.0176 0.148
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0976 0.0736 0.1243
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Schistosoma mansoni tyrosine kinase 0.0515 0.031 0.0965
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0206 0.0025 0.0158
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.1146 0.0892 0.8502
Entamoeba histolytica protein kinase 2, putative 0.027 0.0084 0.0304
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.2503 0.2146 0.3674
Echinococcus granulosus activated cdc42 kinase 1 0.0727 0.0505 0.154
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.0101 0.096
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Onchocerca volvulus 0.1119 0.0868 0.2606
Brugia malayi phosphoinositide-dependent protein kinase I 0.0204 0.0023 0.0022
Schistosoma mansoni serine/threonine-protein kinase 0.0297 0.0108 0.0335
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0659 0.0443 0.0442
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.1252 0.099 0.9432
Echinococcus multilocularis serine:threonine protein kinase N2 0.1004 0.0762 0.1288
Giardia lamblia Kinase, NEK 0.0252 0.0067 0.0419
Entamoeba histolytica protein kinase, putative 0.0188 0.0008 0.0015
Plasmodium falciparum casein kinase 2, alpha subunit 0.0221 0.0038 0.0286
Echinococcus granulosus mitogen activated protein kinase 15 0.0237 0.0053 0.0122
Entamoeba histolytica protein kinase domain containing protein 0.0221 0.0038 0.0129
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.1146 0.0892 0.8502
Schistosoma mansoni vam6/vps39 related 0.0816 0.0588 0.1833
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.1146 0.0892 0.1513
Entamoeba histolytica protein kinase, putative 0.0582 0.0372 0.1405
Entamoeba histolytica hypothetical protein 0.0188 0.0008 0.0015
Schistosoma mansoni adapter molecule crk 0.0199 0.0018 0.0054
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0319 0.0128 0.1213
Trypanosoma cruzi NIMA-related kinase, putative 0.0188 0.0008 0.0068
Echinococcus multilocularis epidermal growth factor receptor 0.0672 0.0455 0.0759
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Plasmodium falciparum casein kinase 1 0.0488 0.0285 0.2658
Entamoeba histolytica protein kinase domain containing protein 0.0237 0.0053 0.0187
Schistosoma mansoni serine/threonine protein kinase 0.0204 0.0023 0.0068
Schistosoma mansoni serine/threonine protein kinase 0.0473 0.0271 0.0843
Schistosoma mansoni protein kinase 0.0237 0.0053 0.0163
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0672 0.0455 0.1382
Plasmodium vivax glycogen synthase kinase 3, putative 0.1252 0.099 0.9432
Trichomonas vaginalis AGC family protein kinase 0.0582 0.0372 0.3543
Schistosoma mansoni serine/threonine protein kinase 0.0968 0.0728 0.2271
Echinococcus granulosus calcium activated potassium channel 0.0473 0.0271 0.0806
Trichomonas vaginalis AGC family protein kinase 0.0237 0.0053 0.0506
Loa Loa (eye worm) hypothetical protein 0.0247 0.0062 0.0061
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0472 0.027 0.044
Trichomonas vaginalis CMGC family protein kinase 0.0221 0.0038 0.0361
Trichomonas vaginalis AGC family protein kinase 0.1146 0.0892 0.8503
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Trichomonas vaginalis CK1 family protein kinase 0.0488 0.0285 0.2715
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.0101 0.096
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0704 0.0485 0.0484
Giardia lamblia Kinase, CMGC CDK 0.1217 0.0958 0.9108
Schistosoma mansoni protein kinase 0.1891 0.158 0.4932
Plasmodium falciparum protein serine/threonine kinase-1 0.1316 0.1049 1
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0559 0.035 0.0579
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0559 0.035 0.0349
Loa Loa (eye worm) AGC/PKA protein kinase 0.1146 0.0892 0.0891
Loa Loa (eye worm) hypothetical protein 0.0598 0.0387 0.0386
Entamoeba histolytica protein kinase, putative 0.1252 0.099 0.3768
Loa Loa (eye worm) hypothetical protein 0.1146 0.0892 0.0891
Leishmania major protein kinase A catalytic subunit isoform 2 0.1146 0.0892 0.8492
Loa Loa (eye worm) hypothetical protein 0.0219 0.0037 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0206 0.0025 0.0225
Schistosoma mansoni kinase 0.0592 0.0381 0.1186
Brugia malayi Protein kinase domain containing protein 0.0309 0.0119 0.0118
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.1316 0.1049 1
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0025 0.0235
Schistosoma mansoni serine/threonine protein kinase 0.3018 0.2622 0.8184
Trypanosoma brucei cdc2-related kinase 3 0.1217 0.0958 0.9122
Loa Loa (eye worm) TK/FER protein kinase 0.029 0.0102 0.0101
Brugia malayi Casein kinase II, alpha chain 0.0221 0.0038 0.0037
Brugia malayi Kinase associated domain 1 family protein 0.0311 0.0122 0.0121
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0206 0.0025 0.0235
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0598 0.0386 0.0641
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0454 0.0254 0.0253
Leishmania major protein kinase, putative 0.0319 0.0128 0.1153
Trichomonas vaginalis CAMK family protein kinase 0.037 0.0176 0.1675
Trichomonas vaginalis CMGC family protein kinase 0.0206 0.0025 0.0234
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0188 0.0008 0.0068
Brugia malayi Variant SH3 domain containing protein 0.0248 0.0063 0.0062
Loa Loa (eye worm) hypothetical protein 0.029 0.0102 0.0101
Brugia malayi Protein kinase domain 0.0316 0.0126 0.0125
Brugia malayi serine/threonine protein kinase 6 0.0454 0.0253 0.0252
Schistosoma mansoni serine/threonine protein kinase 0.0563 0.0354 0.1103
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.1136 0.0883 0.2724
Schistosoma mansoni serine/threonine protein kinase 0.0251 0.0066 0.0202
Schistosoma mansoni vav2 0.0275 0.0088 0.0271
Echinococcus granulosus dual specificity protein kinase clk2 0.1316 0.1049 0.3247
Trichomonas vaginalis AGC family protein kinase 0.0582 0.0372 0.3543
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0603 0.0391 0.039
Echinococcus granulosus casein kinase I gamma 0.032 0.013 0.0362
Brugia malayi Protein kinase domain containing protein 0.0363 0.017 0.0169
Entamoeba histolytica protein kinase, putative 0.0206 0.0024 0.0076
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0277 0.009 0.013
Trichomonas vaginalis AGC family protein kinase 0.0582 0.0372 0.3543
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0735 0.0513 0.1565
Trypanosoma brucei rac serine-threonine kinase, putative 0.0582 0.0372 0.3492
Brugia malayi P38 map kinase family protein 2 0.0706 0.0486 0.0485
Trypanosoma brucei protein kinase, putative 0.0282 0.0094 0.0827
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Brugia malayi Protein kinase domain containing protein 0.0958 0.0719 0.0718
Entamoeba histolytica cell division protein kinase 2, putative 0.1217 0.0958 0.3644
Brugia malayi Protein kinase domain containing protein 0.0204 0.0023 0.0022
Echinococcus granulosus mitogen activated protein kinase 14 0.0706 0.0486 0.1479
Trichomonas vaginalis AGC family protein kinase 0.0204 0.0023 0.0217
Trypanosoma cruzi cdc2-related kinase 1 0.1217 0.0958 0.9128
Trichomonas vaginalis CMGC family protein kinase 0.1119 0.0868 0.827
Echinococcus multilocularis calcium dependent protein kinase 0.0293 0.0104 0.0155
Entamoeba histolytica protein kinase domain containing protein 0.3018 0.2622 1
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.2992 0.2598 0.4452
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0534 0.0327 0.054
Schistosoma mansoni serine/threonine protein kinase 0.0237 0.0053 0.0163
Brugia malayi hypothetical protein 0.029 0.0102 0.0101
Loa Loa (eye worm) SRC-1 0.0534 0.0327 0.0326
Echinococcus multilocularis cyclin dependent kinase 19 0.0968 0.0728 0.123
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0871 0.0639 0.1076
Brugia malayi Immunoglobulin I-set domain containing protein 0.1912 0.16 0.1599
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0454 0.0253 0.2352
Loa Loa (eye worm) hypothetical protein 0.0493 0.029 0.0289
Brugia malayi Protein kinase domain containing protein 0.029 0.0102 0.0101
Echinococcus granulosus dual specificity 0.116 0.0905 0.2795
Echinococcus granulosus tyrosine protein kinase Blk 0.0468 0.0266 0.0789
Giardia lamblia Kinase, STE STE20 0.0517 0.0311 0.2802
Entamoeba histolytica casein kinase, putative 0.0488 0.0285 0.1073
Entamoeba histolytica protein kinase, putative 0.116 0.0905 0.3443
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0248 0.0063 0.0084
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.0101 0.096
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0195 0.0014 0.0000021174
Trichomonas vaginalis AGC family protein kinase 0.028 0.0092 0.0881
Brugia malayi SH2 domain containing protein 0.029 0.0102 0.0101
Brugia malayi Protein kinase domain containing protein 0.032 0.013 0.0129
Schistosoma mansoni protein kinase 0.2503 0.2146 0.6699
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0053 0.0506
Schistosoma mansoni serine/threonine protein kinase 0.0509 0.0304 0.0946
Trichomonas vaginalis CMGC family protein kinase 0.0237 0.0053 0.0506
Loa Loa (eye worm) hypothetical protein 0.057 0.0361 0.036
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0984 0.0743 0.1256
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0252 0.0067 0.0566
Loa Loa (eye worm) TK/FER protein kinase 0.029 0.0102 0.0101
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.2439 0.2087 0.6499
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0265 0.0079 0.0078
Schistosoma mansoni ste20-related kinase 0.1344 0.1076 0.3357
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0319 0.0128 0.0197
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0206 0.0025 0.0158
Echinococcus multilocularis dual specificity protein kinase clk2 0.1316 0.1049 0.1784
Leishmania major protein kinase, putative 0.0517 0.0311 0.2913
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0404 0.0207 0.0605
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.0101 0.096
Loa Loa (eye worm) AGC/AKT protein kinase 0.0582 0.0372 0.0371
Entamoeba histolytica SH2-protein kinase domain containing protein 0.029 0.0102 0.0372
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.0101 0.096
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0404 0.0207 0.0332
Echinococcus multilocularis serine:threonine protein kinase 3 0.17 0.1404 0.2394
Echinococcus multilocularis serine:threonine protein kinase N2 0.0447 0.0247 0.0401
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0316 0.0126 0.0351
Echinococcus multilocularis tyrosine protein kinase Abl 0.0426 0.0227 0.0367
Trypanosoma cruzi casein kinase, putative 0.0488 0.0285 0.2708
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0241 0.0057 0.0073
Echinococcus granulosus roundabout 2 0.0511 0.0306 0.0915
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0188 0.0008 0.0068
Brugia malayi cyclin-dependent kinase 7 homolog 0.0971 0.0731 0.073

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.059 uM Inhibition of caspase3 ChEMBL. 16509578
IC50 (binding) = 0.059 uM Inhibition of caspase3 ChEMBL. 16509578

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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