Detailed information for compound 1279308

Basic information

Technical information
  • TDR Targets ID: 1279308
  • Name: N-[2-(4-chlorophenyl)ethyl]-1-(cyclobutanecar bonyl)-2-methyl-2,3-dihydroindole-5-sulfonami de
  • MW: 432.964 | Formula: C22H25ClN2O3S
  • H donors: 1 H acceptors: 3 LogP: 4.3 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)CCNS(=O)(=O)c1ccc2c(c1)CC(N2C(=O)C1CCC1)C
  • InChi: 1S/C22H25ClN2O3S/c1-15-13-18-14-20(9-10-21(18)25(15)22(26)17-3-2-4-17)29(27,28)24-12-11-16-5-7-19(23)8-6-16/h5-10,14-15,17,24H,2-4,11-13H2,1H3
  • InChiKey: WCMIDJJZZSORDI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(4-chlorophenyl)ethyl]-1-(cyclobutanecarbonyl)-2-methyl-indoline-5-sulfonamide
  • N-[2-(4-chlorophenyl)ethyl]-1-(cyclobutyl-oxomethyl)-2-methyl-5-indolinesulfonamide
  • N-[2-(4-chlorophenyl)ethyl]-1-cyclobutylcarbonyl-2-methyl-2,3-dihydroindole-5-sulfonamide
  • E699-1337
  • NCGC00124517-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0204 0.2269 0.2945
Leishmania major carbonic anhydrase-like protein 0.0541 0.6192 1
Loa Loa (eye worm) norepinephrine transporter 0.0016 0.0069 0.011
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0031 0.0251 0.098
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0039 0.0054
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0779 0.0992
Entamoeba histolytica hypothetical protein 0.0023 0.0154 0.1289
Loa Loa (eye worm) hypothetical protein 0.0029 0.0223 0.0357
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0035 0.0047
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0295 0.1021
Loa Loa (eye worm) hypothetical protein 0.0046 0.0419 0.0675
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.011 0.0177
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0031 0.0251 0.138
Schistosoma mansoni protein kinase 0.0063 0.062 0.0785
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0031 0.0251 0.098
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0063 0.062 0.1002
Leishmania major glucose transporter/membrane transporter D2, putative 0.0063 0.0626 0.1003
Schistosoma mansoni cytochrome P450 0.0031 0.0251 0.0301
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0035 0.0164
Brugia malayi Sugar transporter family protein 0.0029 0.0223 0.0359
Leishmania major cytochrome p450-like protein 0.0031 0.0251 0.0397
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0542 0.0866
Loa Loa (eye worm) hypothetical protein 0.016 0.1748 0.2822
Brugia malayi RNA, U transporter 1 0.008 0.0822 0.1328
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0628
Trichomonas vaginalis conserved hypothetical protein 0.0204 0.2269 0.8009
Echinococcus granulosus calcium dependent protein kinase 0.0059 0.0572 0.0745
Plasmodium falciparum proline--tRNA ligase 0.0071 0.0721 0.07
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.058 0.0868
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0046 0.0419 0.0668
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0298 0.1166
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0016 0.0069 0.0089
Loa Loa (eye worm) hypothetical protein 0.0016 0.0069 0.011
Loa Loa (eye worm) animal heme peroxidase 0.0043 0.039 0.0628
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Trypanosoma brucei THT1 - hexose transporter, putative 0.0063 0.0626 0.1003
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.013 0.02
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0589 0.0951
Trichomonas vaginalis ran, putative 0.0021 0.013 0.0437
Echinococcus multilocularis solute carrier family 22 0.0029 0.0223 0.0289
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0035 0.0103
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0081 0.0121
Brugia malayi major facilitator superfamily protein 0.0029 0.0223 0.0359
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0313 0.0504
Trypanosoma brucei sugar transporter, putative 0.0029 0.0223 0.035
Schistosoma mansoni sodium-dependent amino acid transporter 0.0016 0.0069 0.0063
Mycobacterium leprae putative cytochrome p450 0.0031 0.0251 0.2552
Trypanosoma brucei glucose transporter, putative 0.0063 0.0626 0.1003
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0022 0.0025
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.1721 0.2247
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0298 0.0277
Schistosoma mansoni single-minded 0.0048 0.0442 0.0551
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0016 0.0069 0.0096
Loa Loa (eye worm) hypothetical protein 0.0016 0.0069 0.011
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Trypanosoma brucei cytochrome P450, putative 0.0031 0.0251 0.0397
Loa Loa (eye worm) beta-lactamase 0.0035 0.0298 0.0479
Plasmodium falciparum mitogen-activated protein kinase 2 0.0331 0.374 0.3726
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0039 0.0339 0.133
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0032 0.0091
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0069 0.0112
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2832 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0016 0.0069 0.011
Trypanosoma brucei glucosidase, putative 0.0035 0.0295 0.0466
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0063 0.062 0.0809
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2237 0.3612
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.058 0.3228
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0071 0.0721 0.1155
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0779 0.0992
Loa Loa (eye worm) animal heme peroxidase 0.0043 0.039 0.0628
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0223 0.0201
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0506 0.0634
Trypanosoma brucei THT1 - hexose transporter, putative 0.0063 0.0626 0.1003
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0031 0.0251 0.098
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0031 0.0251 0.138
Brugia malayi hypothetical protein 0.0029 0.0223 0.0359
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0039 0.0117
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0081 0.0121
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0035 0.0014
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0154 0.0524
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.058 0.0928
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2832 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0035 0.0047
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0216 0.034
Giardia lamblia Prolyl-tRNA synthetase 0.0061 0.0602 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.2832 0.4573
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0298 0.0481
Trypanosoma brucei glucose transporter, putative 0.0063 0.0626 0.1003
Leishmania major protein kinase, putative 0.0017 0.0081 0.0121
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0031 0.0251 0.138
Schistosoma mansoni sugar transporter 0.0029 0.0223 0.0263
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0498 0.0802
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0035 0.0014
Echinococcus granulosus carbonic anhydrase 0.0254 0.2849 0.3721
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0223 0.1218
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0031 0.0251 0.138
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0103 0.1088 0.1397
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.0022 0.0033
Mycobacterium tuberculosis Conserved protein 0.0035 0.0298 0.1166
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0046 0.0419 0.0668
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0628
Loa Loa (eye worm) cytochrome P450 family protein 0.0106 0.1121 0.1809
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.011 0.0141
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.013 0.02
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0035 0.0047
Schistosoma mansoni alpha-glucosidase 0.0135 0.1466 0.1892
Leishmania major protein kinase, putative 0.0017 0.0081 0.0121
Loa Loa (eye worm) sugar transporter 0.0204 0.2269 0.3664
Plasmodium vivax calcium-dependent protein kinase, putative 0.0063 0.0621 0.0601
Schistosoma mansoni carbonic anhydrase-related 0.0254 0.2849 0.3704
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0589 0.0949
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0628
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0061 0.0602 0.0761
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0331 0.374 0.3726
Echinococcus granulosus peroxidasin 0.0043 0.039 0.0508
Plasmodium vivax hexose transporter 0.0204 0.2269 0.2253
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0628
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1924 0.6785
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0223 0.0359
Loa Loa (eye worm) hypothetical protein 0.0254 0.2849 0.46
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.0022 0.0027
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0061 0.0602 0.0973
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0374 0.0353
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0298 0.3039
Onchocerca volvulus 0.0091 0.0948 0.3624
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0254 0.2849 0.4601
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.251 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0035 0.0047
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0223 0.1218
Schistosoma mansoni alpha-glucosidase 0.0135 0.1466 0.1892
Onchocerca volvulus 0.0035 0.0298 0.1053
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0628
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0298 0.0362
Echinococcus multilocularis geminin 0.0166 0.182 0.2376
Toxoplasma gondii thioredoxin reductase 0.0037 0.0313 0.0465
Schistosoma mansoni ran 0.0021 0.013 0.0141
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0211 0.0274
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0016 0.0069 0.0063
Brugia malayi hypothetical protein 0.0016 0.0069 0.0112
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0231 0.03
Echinococcus granulosus solute carrier family 22 0.0029 0.0223 0.0289
Mycobacterium ulcerans epoxide hydrolase EphA 0.0163 0.1784 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0035 0.0047
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0374 0.0556
Toxoplasma gondii sugar transporter ST3 0.0029 0.0223 0.0327
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0374 0.0556
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0031 0.0251 0.138
Schistosoma mansoni hypothetical protein 0.0254 0.2849 0.3704
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0541 0.6192 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0223 1
Echinococcus multilocularis 0.0031 0.0251 0.0327
Schistosoma mansoni ran 0.0021 0.013 0.0141
Loa Loa (eye worm) hypothetical protein 0.0061 0.0602 0.0971
Onchocerca volvulus 0.0029 0.0223 0.0754
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0216 0.0318
Onchocerca volvulus 0.0029 0.0223 0.0754
Toxoplasma gondii hypothetical protein 0.0016 0.0069 0.0096
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0032 0.0091
Loa Loa (eye worm) hypothetical protein 0.0016 0.0069 0.011
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0061 0.0602 0.0761
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0298 0.1166
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.062 0.0809
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0223 0.0766
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0542 0.3013
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0223 0.0289
Echinococcus granulosus lysyl tRNA synthetase 0.0046 0.0419 0.0546
Brugia malayi lysyl-tRNA synthetase 0.0046 0.0419 0.0677
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0016 0.0069 0.0112
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0628
Schistosoma mansoni lipoxygenase 0.0118 0.1257 0.1619
Brugia malayi RNA binding protein 0.0076 0.0779 0.1258
Echinococcus multilocularis carbonic anhydrase 0.0254 0.2849 0.3721
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0628
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0035 0.0057
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0298 0.1166
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0779 0.1256
Onchocerca volvulus 0.0016 0.0069 0.0149
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0251 0.0397
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0298 0.0388
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0251 0.0404
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0223 0.0865
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.013 0.0168
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0063 0.0621 0.0601
Loa Loa (eye worm) hypothetical protein 0.0016 0.0069 0.011
Trypanosoma brucei glucose transporter, putative 0.0063 0.0626 0.1003
Schistosoma mansoni glucose transport protein 0.0204 0.2269 0.2945
Loa Loa (eye worm) hypothetical protein 0.0103 0.1088 0.1755
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0031 0.0251 0.138
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0031 0.0251 0.138
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0039 0.0054
Entamoeba histolytica protein kinase, putative 0.0063 0.062 0.5823
Loa Loa (eye worm) cytochrome P450 0.0031 0.0251 0.0404
Brugia malayi Sugar transporter family protein 0.0204 0.2269 0.3665
Leishmania major importin beta-1 subunit, putative 0.0023 0.0154 0.024
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0594 0.0751
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0039 0.0117
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0035 0.0047
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0779 0.1256
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0204 0.2269 0.2964
Echinococcus multilocularis solute carrier family 22 0.0029 0.0223 0.0289
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0295 0.1021
Onchocerca volvulus 0.0035 0.0298 0.1053
Schistosoma mansoni peroxidasin 0.0043 0.039 0.0483
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0063 0.0621 0.0601
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0022 0.0055
Plasmodium falciparum glutathione reductase 0.0013 0.0035 0.0014
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0016 0.0069 0.0063
Plasmodium falciparum carbonic anhydrase 0.0254 0.2849 0.2834
Brugia malayi hypothetical protein 0.0033 0.0271 0.0438
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2832 1
Schistosoma mansoni carbonic anhydrase-related 0.0254 0.2849 0.3704
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0541 0.6192 0.8084
Schistosoma mansoni loxhd1 0.002 0.0117 0.0124
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.7655 1
Brugia malayi Animal haem peroxidase family protein 0.0043 0.039 0.063
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.013 0.02
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.058 0.0756
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0032 0.0091
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.058 0.0756
Loa Loa (eye worm) hypothetical protein 0.0254 0.2849 0.46
Schistosoma mansoni hypothetical protein 0.0019 0.011 0.0115
Plasmodium falciparum calcium-dependent protein kinase 5 0.0063 0.0621 0.0601
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0012 0.0032 0.0255
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0628
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0031 0.0251 0.138
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0231 0.0274
Giardia lamblia Hexose transporter 0.0029 0.0223 0.346
Loa Loa (eye worm) hypothetical protein 0.0016 0.0069 0.011
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0967 0.3838
Onchocerca volvulus 0.0029 0.0231 0.0787
Onchocerca volvulus 0.0029 0.0223 0.0754
Echinococcus granulosus importin subunit beta 1 0.0028 0.0216 0.0281
Loa Loa (eye worm) hypoxia-induced factor 1 0.0147 0.1604 0.2589
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0031 0.0251 0.098
Schistosoma mansoni rab6-interacting 0.002 0.0117 0.0124
Plasmodium falciparum hexose transporter 0.0204 0.2269 0.2253
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.154 0.2487
Schistosoma mansoni hypothetical protein 0.0166 0.182 0.2355
Onchocerca volvulus 0.0029 0.0223 0.0754
Chlamydia trachomatis lysine--tRNA ligase 0.0046 0.0419 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0479
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.062 0.0809
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0223 0.035
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0295 0.0474
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.011 0.0141
Brugia malayi Cytochrome P450 family protein 0.0031 0.0251 0.0406
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0103 0.1088 0.142
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0298 0.0481
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0298 0.1166
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0223 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0457 0.1595
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.013 0.0209
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.2577 0.4161
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2832 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0069 0.0063
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0046 0.0419 0.1462
Echinococcus multilocularis solute carrier family 22 0.0029 0.0223 0.0289
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0016 0.0069 0.0096
Leishmania major trypanothione reductase 0.0037 0.0313 0.0497
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0374 0.1301
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0298 0.1166
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0035 0.0014
Onchocerca volvulus 0.0029 0.0223 0.0754
Brugia malayi Peroxidasin 0.0043 0.039 0.063
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.1494 0.195
Brugia malayi Cam kinase protein 1 0.0063 0.062 0.1002
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.182 0.6417
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0063 0.0621 0.093
Echinococcus multilocularis GPCR, family 2 0.0019 0.011 0.0141
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.0022 0.0027
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0482 0.0461
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0223 0.1218
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0035 0.0341
Echinococcus granulosus snurportin 1 0.0301 0.3397 0.4437
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0061 0.0602 0.211
Brugia malayi Pre-SET motif family protein 0.0202 0.2237 0.3613
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0298 0.1643
Loa Loa (eye worm) doublecortin family protein 0.002 0.0117 0.0186
Echinococcus granulosus serine:threonine protein kinase:endoribonuclease 0.01 0.105 0.137
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.3397 0.5485
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0035 0.0047
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0223 0.035
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0223 0.0766
Loa Loa (eye worm) CYP4Cod1 0.0031 0.0251 0.0404
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0295 0.0476
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0223 0.035
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0223 0.035
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.0022 0.0027
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.182 0.6417
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.154 0.1989
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0061 0.0602 0.6202
Echinococcus granulosus single minded 2 0.0035 0.0298 0.0388
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2832 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0231 0.0371
Plasmodium falciparum thioredoxin reductase 0.0037 0.0313 0.0292
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0204 0.2269 0.2964
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Echinococcus multilocularis sodium and chloride dependent glycine 0.0016 0.0069 0.0089
Echinococcus granulosus sodium and chloride dependent glycine 0.0016 0.0069 0.0089
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.182 0.6417
Toxoplasma gondii lysine-tRNA ligase 0.0046 0.0419 0.0625
Leishmania major lysyl-tRNA synthetase, putative 0.0046 0.0419 0.0668
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0035 0.0047
Echinococcus granulosus tar DNA binding protein 0.0076 0.0779 0.1016
Echinococcus multilocularis sodium and chloride dependent glycine 0.0016 0.0069 0.0089
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0022 0.0024
Echinococcus granulosus cpg binding protein 0.003 0.0234 0.0304
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.013 0.0187
Brugia malayi Animal haem peroxidase family protein 0.0043 0.039 0.063
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.062 0.0809
Brugia malayi TAR-binding protein 0.0076 0.0779 0.1258
Onchocerca volvulus 0.0029 0.0223 0.0754
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0628
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.004 0.0354 0.123
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0039 0.0171
Brugia malayi beta-lactamase family protein 0.0035 0.0298 0.0481
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0175
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.0032 0.004
Plasmodium falciparum protein kinase 7 0.0578 0.662 0.6613
Trypanosoma cruzi hexose transporter, putative 0.0063 0.0626 0.1003
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0154 0.0524
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0012 0.0032 0.0091
Toxoplasma gondii cytochrome p450 superfamily protein 0.0031 0.0251 0.0371
Loa Loa (eye worm) hypothetical protein 0.0041 0.0367 0.0591
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0298 0.1643
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0542 0.3013
Leishmania major glucose transporter, lmgt3 0.0063 0.0626 0.1003
Entamoeba histolytica Ran family GTPase 0.0021 0.013 0.105
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0223 0.0766
Trypanosoma brucei carbonic anhydrase-like protein 0.0541 0.6192 1
Brugia malayi glutathione reductase 0.0037 0.0313 0.0506
Toxoplasma gondii sugar transporter ST2 0.0029 0.0223 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0223 0.0766
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0035 0.0014
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0031 0.0251 0.098
Brugia malayi Doublecortin family protein 0.002 0.0117 0.0188
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.1721 0.278
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0117 0.0095
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0031 0.0251 0.0397
Giardia lamblia Sugar-proton symporter 0.0029 0.0223 0.346
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0295 0.0466
Loa Loa (eye worm) hypothetical protein 0.0029 0.0223 0.0357
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0022 0.0162
Echinococcus multilocularis aryl hydrocarbon receptor 0.0012 0.0032 0.004
Loa Loa (eye worm) serotonin transporter b 0.0016 0.0069 0.011
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.062 0.0809
Loa Loa (eye worm) hypothetical protein 0.0254 0.2849 0.46
Leishmania major glucose transporter, lmgt1 0.0063 0.0626 0.1003
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0061 0.0602 0.5645
Loa Loa (eye worm) hypothetical protein 0.0029 0.0223 0.0357
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.0022 0.0027
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0031 0.0251 0.138
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2832 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0295 0.0383
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0154 0.024
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0031 0.0251 0.098
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0231 0.0274
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.0032 0.0049
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0016 0.0069 0.0096
Trichomonas vaginalis glucose transporter, putative 0.0063 0.0626 0.2195
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0081 0.0121
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0069 0.0063
Schistosoma mansoni hypothetical protein 0.0031 0.0251 0.0301
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0479
Onchocerca volvulus 0.0029 0.0223 0.0754
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0117 0.0095
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.182 0.6417
Brugia malayi hypothetical protein 0.0051 0.0482 0.0778
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0223 0.035
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0016 0.0069 0.0089
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0103 0.1088 0.1397
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0016 0.0069 0.0089
Echinococcus multilocularis serotonin transporter 0.0016 0.0069 0.0089
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0333 0.0312
Brugia malayi hypothetical protein 0.0043 0.039 0.063
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0012 0.0022 0.0035
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0031 0.0251 0.138
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0254 0.2849 0.4601
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0117 0.0151
Brugia malayi glycyl-tRNA synthetase 0.0012 0.0022 0.0035
Entamoeba histolytica protein kinase, putative 0.01 0.105 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0031 0.0251 0.138
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.0419 0.2324
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0032 0.0091
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0032 0.0091
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0541 0.6192 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0482 0.0769
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0083 0.0859 0.3406
Onchocerca volvulus Peroxidase homolog 0.0043 0.039 0.1417
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0251 0.0397
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0223 0.0766
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0031 0.0251 0.0397
Leishmania major glucose transporter, lmgt2 0.0063 0.0626 0.1003
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Onchocerca volvulus 0.0029 0.0223 0.0754
Loa Loa (eye worm) sugar transporter 0.0029 0.0223 0.0357
Onchocerca volvulus 0.0029 0.0223 0.0754
Onchocerca volvulus Dual oxidase homolog 0.0043 0.039 0.1417
Echinococcus granulosus carbonic anhydrase 0.0254 0.2849 0.3721
Echinococcus granulosus General substrate transporter 0.0176 0.1935 0.2526
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0231 0.0274
Onchocerca volvulus 0.0029 0.0223 0.0754
Leishmania major cytochrome p450-like protein 0.0031 0.0251 0.0397
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.014 0.0754
Schistosoma mansoni cpg binding protein 0.003 0.0234 0.0278
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0628
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0035 0.0018
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0012 0.0022 0.0035
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.013 0.0108
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.011 0.0141
Onchocerca volvulus Peroxidase homolog 0.0043 0.039 0.1417
Loa Loa (eye worm) hypothetical protein 0.0028 0.0216 0.0347
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0542 0.0875
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0071 0.0721 0.1155
Brugia malayi hypothetical protein 0.002 0.0117 0.0188
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0035 0.0044
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0031 0.0251 0.138
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0223 0.0766
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Schistosoma mansoni carbonic anhydrase 0.0254 0.2849 0.3704
Brugia malayi Cytochrome P450 family protein 0.0031 0.0251 0.0406
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0223 0.0865
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0298 0.1166
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.013 0.0108
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0063 0.0621 0.0601
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0022 0.0025
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0216 0.0281
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0061 0.0602 0.0973
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0295 0.0383
Echinococcus granulosus microtubule associated protein 2 0.0667 0.7655 1
Plasmodium falciparum importin beta, putative 0.0028 0.0216 0.0195
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0032 0.0042
Echinococcus granulosus serotonin transporter 0.0016 0.0069 0.0089
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0081 0.0121
Toxoplasma gondii hypothetical protein 0.0016 0.0069 0.0096
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0231 0.034
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0254 0.2849 0.4601
Toxoplasma gondii facilitative glucose transporter GT1 0.0204 0.2269 0.3422
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0542 0.0706
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0035 0.0044
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0035 0.0044
Schistosoma mansoni hypothetical protein 0.0301 0.3397 0.4422
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0039 0.0054
Loa Loa (eye worm) hypothetical protein 0.0029 0.0223 0.0357
Schistosoma mansoni peroxidasin 0.0043 0.039 0.0483
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0779 0.1258
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0031 0.0251 0.138
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Trypanosoma brucei glucose transporter 2A 0.0063 0.0626 0.1003
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0779 0.0992
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0031 0.0251 0.098
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0295 0.1021
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0061
Brugia malayi Cytochrome P450 family protein 0.0106 0.1121 0.181
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0117 0.0151
Loa Loa (eye worm) hypothetical protein 0.0029 0.0223 0.0357
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Echinococcus multilocularis dnaJ subfamily B 0.04 0.4551 0.5945
Onchocerca volvulus 0.002 0.0117 0.0335
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0022 0.0062
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0083 0.0859 0.3406
Leishmania major protein kinase, putative 0.0063 0.062 0.0993
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0069 0.0063
Plasmodium vivax glutathione reductase, putative 0.0037 0.0313 0.0292
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1924 0.6785
Leishmania major cytochrome p450-like protein 0.0031 0.0251 0.0397
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.014 1
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.062 0.2174
Loa Loa (eye worm) hypothetical protein 0.0029 0.0223 0.0357
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Onchocerca volvulus 0.002 0.0117 0.0335
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0231 0.03
Brugia malayi hypothetical protein 0.002 0.0117 0.0188
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.0419 0.0521
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.1721 0.2779
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0117 0.0151
Trichomonas vaginalis adenylate cyclase, putative 0.0012 0.0032 0.0091
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0069 0.0048
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0083 0.0859 0.3406
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0626 0.2195
Mycobacterium tuberculosis Probable dehydrogenase 0.0083 0.0859 0.3406
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0032 0.0091
Plasmodium falciparum calcium-dependent protein kinase 1 0.0063 0.0621 0.0601
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0295 0.0466
Onchocerca volvulus 0.0035 0.0298 0.1053
Leishmania major hypothetical protein, conserved 0.0029 0.0223 0.035
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0298 0.1034
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0031 0.0251 0.0397
Loa Loa (eye worm) hypothetical protein 0.0029 0.0223 0.0357
Brugia malayi CXXC zinc finger family protein 0.0028 0.0215 0.0347
Brugia malayi beta-lactamase family protein 0.0035 0.0298 0.0481
Brugia malayi cytochrome P450 0.0031 0.0251 0.0406
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0298 0.0472
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0031 0.0251 0.138
Plasmodium falciparum thioredoxin reductase 0.0013 0.0035 0.0014
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0016 0.0069 0.0063
Loa Loa (eye worm) blistered cuticle protein 3 0.0043 0.039 0.0628
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0479
Echinococcus multilocularis carbonic anhydrase 0.0254 0.2849 0.3721
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0022 0.0025
Brugia malayi Ribonuclease 2-5A family protein 0.01 0.105 0.1696
Schistosoma mansoni rab6-interacting 0.002 0.0117 0.0124
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.1721 0.2247
Onchocerca volvulus 0.0016 0.0069 0.0149
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0298 0.1643
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0628
Echinococcus granulosus solute carrier family 22 0.0029 0.0223 0.0289
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0295 0.1021
Mycobacterium ulcerans beta-lactamase 0.0035 0.0298 0.1643
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1249 0.2015
Echinococcus multilocularis serine:threonine protein kinase:endoribonuclease 0.01 0.105 0.137
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.0022 0.0033
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0479
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0039 0.0063
Echinococcus granulosus geminin 0.0166 0.182 0.2376
Plasmodium vivax sugar transporter, putative 0.0029 0.0223 0.0201
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0223 0.0289
Leishmania major hypothetical protein, conserved 0.0035 0.0298 0.0472
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0967 0.3838
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.154 0.2011
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.013 0.0168
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0031 0.0251 0.098
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0069 0.0063
Onchocerca volvulus 0.0029 0.0223 0.0754
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0069 0.0112
Schistosoma mansoni carbonic anhydrase-related 0.0254 0.2849 0.3704
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.2832 0.4574
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0117 0.0151
Loa Loa (eye worm) acetyltransferase 0.0142 0.154 0.2486
Plasmodium falciparum lysine--tRNA ligase 0.0046 0.0419 0.0398
Plasmodium falciparum calcium-dependent protein kinase 3 0.0063 0.0621 0.0601
Entamoeba histolytica protein kinase, putative 0.0063 0.062 0.5823
Loa Loa (eye worm) IRE protein kinase 0.01 0.105 0.1694
Schistosoma mansoni lipoxygenase 0.0082 0.0845 0.1079
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0186
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0031 0.0251 0.098
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0031 0.0251 0.098
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0103 0.1088 0.142
Loa Loa (eye worm) hypothetical protein 0.006 0.0589 0.0949
Echinococcus multilocularis calcium dependent protein kinase 0.0059 0.0572 0.0745
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Loa Loa (eye worm) hypothetical protein 0.0029 0.0223 0.0357
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Echinococcus granulosus GPCR family 2 0.0019 0.011 0.0141
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0031 0.0251 0.138
Trichomonas vaginalis serine threonine-protein kinase, putative 0.0049 0.0457 0.1595
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0626 0.2195
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.0419 0.2324
Trichomonas vaginalis esterase, putative 0.0035 0.0298 0.1034
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0031 0.0251 0.098
Mycobacterium leprae Possible regulatory protein 0.0012 0.0032 0.0268
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0223 0.0357
Loa Loa (eye worm) hypothetical protein 0.0012 0.0032 0.0049
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0251 0.0404
Plasmodium falciparum calcium-dependent protein kinase 4 0.0063 0.0621 0.0601
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0561 0.0839
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0039 0.0117
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0313 0.0292
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.0419 0.0521
Onchocerca volvulus 0.0029 0.0223 0.0754
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0542 0.0681
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0035 0.0047
Onchocerca volvulus 0.0016 0.0069 0.0149
Schistosoma mansoni protein kinase 0.0063 0.062 0.0785
Onchocerca volvulus 0.0229 0.2561 1
Schistosoma mansoni protein kinase 0.0063 0.062 0.0785
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.1257 0.1641
Brugia malayi major facilitator superfamily protein 0.0029 0.0223 0.0359
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0295 0.1021
Brugia malayi hypothetical protein 0.0029 0.0223 0.0359
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0298 0.0472
Leishmania major hypothetical protein, conserved 0.0051 0.0482 0.0769
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0154 0.02
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0031 0.0251 0.138
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0295 0.1021
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0333 0.3029
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.182 0.6417
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0479
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0223 0.0289
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0298 0.1034
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0626 0.2195
Brugia malayi Animal haem peroxidase family protein 0.0043 0.039 0.063
Treponema pallidum NADH oxidase 0.0013 0.0035 0.1144
Loa Loa (eye worm) hypothetical protein 0.005 0.0468 0.0754
Onchocerca volvulus 0.0016 0.0069 0.0149
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0022 0.0088
Trypanosoma brucei glucose transporter, putative 0.0063 0.0626 0.1003
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0031 0.0251 0.138
Brugia malayi Cytochrome P450 family protein 0.0031 0.0251 0.0406
Loa Loa (eye worm) solute carrier family 6 member 4 0.0016 0.0069 0.011
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0163 0.1784 0.71
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0204 0.2269 0.2964
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0039 0.0029
Mycobacterium leprae Conserved hypothetical protein 0.0031 0.0251 0.2552
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0022 0.0025
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.1721 0.2247
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0223 0.0766
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0022 0.0025
Brugia malayi hypothetical protein 0.016 0.1748 0.2824
Loa Loa (eye worm) hypothetical protein 0.0029 0.0223 0.0357
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0035 0.0047
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.058 0.2292
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0035 0.0233
Trypanosoma cruzi hexose transporter, putative 0.0063 0.0626 0.1003
Loa Loa (eye worm) hypothetical protein 0.0016 0.0069 0.011
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0295 0.0466
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0039 0.0117
Schistosoma mansoni sugar transporter 0.0029 0.0223 0.0263
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0035 0.0044
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0482 0.0461
Schistosoma mansoni sodium/chloride dependent transporter 0.002 0.0118 0.0127
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1249 0.2015
Brugia malayi hypoxia-induced factor 1 0.0147 0.1604 0.2591
Schistosoma mansoni glucose transporter 0.0029 0.0223 0.0263
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0319 0.0415
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0628
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0313 0.1227
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0331 0.374 0.5645
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0482 0.0719
Schistosoma mansoni hypothetical protein 0.04 0.4551 0.5934
Onchocerca volvulus 0.0029 0.0223 0.0754
Echinococcus multilocularis cpg binding protein 0.003 0.0234 0.0304
Schistosoma mansoni hypothetical protein 0.0166 0.182 0.2355
Trichomonas vaginalis set domain proteins, putative 0.0229 0.2561 0.9041
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0039 0.0117
Mycobacterium ulcerans sugar transporter 0.0029 0.0223 0.1218
Plasmodium falciparum glutathione reductase 0.0037 0.0313 0.0292
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0298 0.0472
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.058 0.0731
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0298 0.1034
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0967 0.3838
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0541 0.6192 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0039 0.0117
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0295 0.1021
Brugia malayi beta-lactamase 0.0035 0.0298 0.0481
Loa Loa (eye worm) RNA binding protein 0.0076 0.0779 0.1256
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0223 0.0263
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0022 0.0088
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0215 0.0345
Brugia malayi PAS domain containing protein 0.0048 0.0442 0.0714
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.1257 0.1641
Plasmodium falciparum calcium-dependent protein kinase 2 0.0063 0.0621 0.0601
Brugia malayi Pre-SET motif family protein 0.0029 0.0231 0.0373
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0541 0.6192 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0204 0.2269 0.2964
Brugia malayi Importin beta-1 subunit 0.0028 0.0216 0.0349
Loa Loa (eye worm) animal heme peroxidase 0.0043 0.039 0.0628
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Loa Loa (eye worm) hypothetical protein 0.0016 0.0069 0.011
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0069 0.0112
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0035 0.0164
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.062 0.0809
Brugia malayi Animal haem peroxidase family protein 0.0043 0.039 0.063
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0035 0.0047
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0298 0.0362
Mycobacterium ulcerans lipase LipD 0.0035 0.0298 0.1643
Onchocerca volvulus 0.0043 0.039 0.1417
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0031 0.0251 0.098
Brugia malayi Blistered cuticle protein 3 0.0043 0.039 0.063
Echinococcus granulosus dnaJ subfamily B 0.04 0.4551 0.5945
Echinococcus granulosus carbonic anhydrase II 0.0541 0.6192 0.8089
Echinococcus granulosus carbonic anhydrase 0.0254 0.2849 0.3721
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0046 0.0419 0.4299
Schistosoma mansoni glucose transport protein 0.0204 0.2269 0.2945
Trypanosoma brucei glucose transporter, putative 0.0063 0.0626 0.1003
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0298 0.1166
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.058 0.3228
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0031 0.0251 0.138
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0482 0.0769
Loa Loa (eye worm) hypothetical protein 0.0063 0.062 0.1
Schistosoma mansoni hypothetical protein 0.0023 0.0154 0.0173
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0254 0.2849 0.46
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.0339 0.3465
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0031 0.0251 0.098
Echinococcus granulosus solute carrier family 22 0.0029 0.0223 0.0289
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0589 0.0951
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0298 0.1034
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0541 0.6192 1
Onchocerca volvulus Chorion peroxidase homolog 0.0043 0.039 0.1417
Schistosoma mansoni hypothetical protein 0.0019 0.011 0.0115
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.011 0.0141
Echinococcus multilocularis solute carrier family 22 0.0029 0.0223 0.0289
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Plasmodium vivax proline--tRNA ligase, putative 0.0071 0.0721 0.07
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0032 0.0091
Trypanosoma brucei glucose transporter, putative 0.0063 0.0626 0.1003
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0031 0.0251 0.098
Schistosoma mansoni glucose transport protein 0.0204 0.2269 0.2945
Loa Loa (eye worm) hypothetical protein 0.0029 0.0223 0.0357
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.062 0.0809
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0063 0.0621 0.093
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0083 0.0859 0.3406
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0035 0.0047
Loa Loa (eye worm) hypothetical protein 0.0029 0.0223 0.0357
Trypanosoma brucei trypanothione reductase 0.0037 0.0313 0.0497
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0035 0.0164
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0035 0.0103
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0032 0.0042
Toxoplasma gondii hypothetical protein 0.0254 0.2849 0.4298
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0071 0.0721 0.1155
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0022 0.0024
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.014 0.2978
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0298 0.1034
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0967 1
Toxoplasma gondii ABC1 family protein 0.0035 0.0298 0.0442
Echinococcus multilocularis RUN 0.002 0.0117 0.0151
Trypanosoma cruzi hexose transporter 0.0063 0.0626 0.1003
Loa Loa (eye worm) animal heme peroxidase 0.0043 0.039 0.0628
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.0339 0.133
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0223 0.0766
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0216 0.034
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0626 0.2195
Onchocerca volvulus Putative transporter 0.0029 0.0223 0.0754
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0542 0.2139
Onchocerca volvulus 0.0029 0.0223 0.0754
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0071 0.0721 0.1155
Trypanosoma brucei glucose transporter 1E 0.0063 0.0626 0.1003
Mycobacterium ulcerans hypothetical protein 0.0035 0.0298 0.1643
Loa Loa (eye worm) hypothetical protein 0.0029 0.0223 0.0357
Mycobacterium leprae Probable lipase LipE 0.0035 0.0298 0.3039
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0039 0.0117
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0295 0.2654
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0016 0.0069 0.011
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Schistosoma mansoni polycystin 1-related 0.002 0.0117 0.0124
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0063 0.062 0.1
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0069 0.0063
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.182 0.6417
Schistosoma mansoni hypothetical protein 0.0019 0.011 0.0115
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.013 0.0207
Plasmodium falciparum amino acid transporter, putative 0.0016 0.0069 0.0048
Echinococcus multilocularis lysyl tRNA synthetase 0.0046 0.0419 0.0546
Trypanosoma brucei glucose transporter, putative 0.0063 0.0626 0.1003
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0223 0.0359
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.182 0.6417
Onchocerca volvulus Peroxidasin homolog 0.0043 0.039 0.1417
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0482 0.0769
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0204 0.2269 0.2964
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.011 0.0175
Echinococcus granulosus RUN 0.002 0.0117 0.0151
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0223 0.0327
Leishmania major GTP-binding protein, putative 0.0021 0.013 0.02
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0031 0.0251 0.0397
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0061 0.0602 0.0785
Schistosoma mansoni cpg binding protein 0.003 0.0234 0.0278
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0186
Echinococcus multilocularis peroxidasin 0.0043 0.039 0.0508
Onchocerca volvulus 0.0029 0.0223 0.0754
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0541 0.6192 0.8084
Trypanosoma brucei glucose transporter, putative 0.0063 0.0626 0.1003
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0035 0.0047
Mycobacterium tuberculosis Conserved protein 0.0035 0.0298 0.1166
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0779 0.0992
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0628
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0035 0.0047
Schistosoma mansoni hypothetical protein 0.0041 0.0367 0.0453
Trypanosoma brucei THT1 - hexose transporter, putative 0.0063 0.0626 0.1003
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0063 0.062 0.1
Toxoplasma gondii sugar transporter ST1 0.0029 0.0223 0.0327
Mycobacterium tuberculosis Probable reductase 0.0083 0.0859 0.3406
Onchocerca volvulus 0.0035 0.0298 0.1053
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0031 0.0251 0.098
Echinococcus granulosus sodium and chloride dependent glycine 0.0016 0.0069 0.0089
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0117 0.0151
Loa Loa (eye worm) hypothetical protein 0.0061 0.0602 0.0971
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0298 0.0479
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.058 0.3228
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0061 0.0602 0.0785
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0374 0.0486
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0016 0.0069 0.0089
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0628
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.0032 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0032 0.0091
Plasmodium falciparum transporter, putative 0.0016 0.0069 0.0048
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0295 0.0436
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0103 0.1088 0.1397
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0012 0.0032 0.0091
Loa Loa (eye worm) hypothetical protein 0.0029 0.0223 0.0357
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0035 0.0047
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0031 0.0251 0.138
Plasmodium vivax CDK-related protein kinase 6, putative 0.0868 1 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0063 0.062 0.0993
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0016 0.0069 0.1201
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0295 0.1021
Loa Loa (eye worm) carbonic anhydrase 3 0.0541 0.6192 1
Trypanosoma cruzi hexose transporter, putative 0.0063 0.0626 0.1003
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0295 0.2654
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0442 0.0551
Schistosoma mansoni sugar transporter 0.0029 0.0223 0.0263
Echinococcus multilocularis snurportin 1 0.0301 0.3397 0.4437
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0063 0.0621 0.093
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0032 0.0042
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.013 0.1859
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0298 0.0388
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0319 0.0415
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0071 0.0721 0.108
Treponema pallidum sodium- and chloride- dependent transporter 0.0016 0.0069 0.4034
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0779 0.0992
Loa Loa (eye worm) hypothetical protein 0.0029 0.0223 0.0357
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0374 0.1301
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0035 0.0674
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0254 0.2849 0.4601
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0542 0.0706
Echinococcus granulosus aryl hydrocarbon receptor 0.0012 0.0032 0.004
Brugia malayi MH2 domain containing protein 0.0117 0.1249 0.2017
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0295 0.1021
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0031 0.0251 0.138
Onchocerca volvulus 0.0028 0.0215 0.0725
Brugia malayi follicle stimulating hormone receptor 0.0231 0.2577 0.4162
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0254 0.2849 0.4601
Brugia malayi Sugar transporter family protein 0.0029 0.0223 0.0359
Plasmodium vivax SET domain protein, putative 0.0029 0.0231 0.021
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0154 0.02
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0223 0.0289
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0367 0.0593
Onchocerca volvulus 0.0043 0.039 0.1417
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Mycobacterium tuberculosis Conserved protein 0.0035 0.0298 0.1166
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0482 0.0461
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0031 0.0251 0.098
Loa Loa (eye worm) hypothetical protein 0.0051 0.0482 0.0776
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0204 0.2269 0.2964
Schistosoma mansoni hypothetical protein 0.0019 0.011 0.0115
Schistosoma mansoni importin beta-1 0.0028 0.0216 0.0255
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.058 0.0731
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0231 0.0274
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0035 0.0047
Entamoeba histolytica protein kinase, putative 0.01 0.105 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0031 0.0251 0.098
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0071 0.0721 0.1155
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0313 0.0497
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0204 0.2269 0.2964
Brugia malayi Latrophilin receptor protein 2 0.0019 0.011 0.0177
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.7655 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0035 0.0047
Trichomonas vaginalis glucose transporter, putative 0.0063 0.0626 0.2195
Schistosoma mansoni sugar transporter 0.0029 0.0223 0.0263
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0035 0.0116
Echinococcus multilocularis carbonic anhydrase 0.0254 0.2849 0.3721
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0231 0.03
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0031 0.0251 0.0397
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0154 0.0524
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0291 0.0461
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Loa Loa (eye worm) hypothetical protein 0.0016 0.0069 0.011
Plasmodium vivax importin-beta 2, putative 0.0028 0.0216 0.0195
Loa Loa (eye worm) hypothetical protein 0.0029 0.0223 0.0357
Schistosoma mansoni cpg binding protein 0.0028 0.0215 0.0253
Onchocerca volvulus Peroxidasin homolog 0.0043 0.039 0.1417
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0031 0.0251 0.098
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0016 0.0069 0.0089
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0204 0.2269 0.2964
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Schistosoma mansoni alpha glucosidase 0.0035 0.0295 0.0358
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0223 0.0766
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0031 0.0251 0.138
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0083 0.0859 0.8872
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0031 0.0251 0.098
Echinococcus multilocularis General substrate transporter 0.0176 0.1935 0.2526
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0025 0.0181 0.029
Brugia malayi Animal haem peroxidase family protein 0.0043 0.039 0.063
Plasmodium vivax amine transporter, putative 0.0016 0.0069 0.0048
Onchocerca volvulus 0.0043 0.039 0.1417
Onchocerca volvulus 0.0029 0.0223 0.0754
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0031 0.0251 0.098
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.182 0.7069
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0069 0.0112
Giardia lamblia Lysyl-tRNA synthetase 0.0046 0.0419 0.6849
Toxoplasma gondii protein kinase, putative 0.0578 0.662 1
Schistosoma mansoni hypothetical protein 0.002 0.0117 0.0124
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.062 0.0785
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0779 0.1016
Brugia malayi hypothetical protein 0.0029 0.0223 0.0359
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0117 0.0151
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0039 0.0054
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0039 0.0117
Echinococcus multilocularis carbonic anhydrase II 0.0541 0.6192 0.8089
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0035 0.0674
Loa Loa (eye worm) hypothetical protein 0.0103 0.1088 0.1755
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0298 0.0388
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.062 0.0809
Plasmodium vivax lysine--tRNA ligase, putative 0.0046 0.0419 0.0398
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0626 0.2195
Loa Loa (eye worm) glutathione reductase 0.0037 0.0313 0.0504
Echinococcus granulosus solute carrier family 22 0.0029 0.0223 0.0289
Echinococcus granulosus cytochrome P450 2K1 0.0031 0.0251 0.0327
Brugia malayi Thioredoxin reductase 0.0037 0.0313 0.0506
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0333 0.5365
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0479
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0223 0.0359
Entamoeba histolytica hypothetical protein 0.0046 0.0419 0.3866

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (binding) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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