Detailed information for compound 1296883

Basic information

Technical information
  • TDR Targets ID: 1296883
  • Name: 2-(3-methyl-2-oxobenzimidazol-1-yl)-N-(3-meth ylphenyl)acetamide
  • MW: 295.336 | Formula: C17H17N3O2
  • H donors: 1 H acceptors: 2 LogP: 2.2 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)NC(=O)Cn1c2ccccc2n(c1=O)C
  • InChi: 1S/C17H17N3O2/c1-12-6-5-7-13(10-12)18-16(21)11-20-15-9-4-3-8-14(15)19(2)17(20)22/h3-10H,11H2,1-2H3,(H,18,21)
  • InChiKey: MLKDDINCKWQUSO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3-methyl-2-oxo-benzimidazol-1-yl)-N-(3-methylphenyl)acetamide
  • 2-(3-methyl-2-oxo-1-benzimidazolyl)-N-(3-methylphenyl)acetamide
  • 2-(2-keto-3-methyl-benzimidazol-1-yl)-N-(3-methylphenyl)acetamide
  • 2-(3-methyl-2-oxo-benzimidazol-1-yl)-N-(3-methylphenyl)ethanamide
  • SMR000074421
  • STK238623
  • ZINC00538826
  • 2-(3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-N-(3-methylphenyl)acetamide
  • MLS000099627

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0007 0.0055 0.0104
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0127 0.0788
Schistosoma mansoni serine/threonine protein kinase 0.0005 0.0012 0.0028
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0017 0.0232 0.0721
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0709 0.1345
Echinococcus granulosus tensin 0.0008 0.0059 0.0174
Loa Loa (eye worm) hypothetical protein 0.0038 0.0603 0.1144
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0557 0.175
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.064 0.0635
Loa Loa (eye worm) hypothetical protein 0.0008 0.0059 0.011
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0008 0.0059 0.0174
Echinococcus granulosus kelch ECH associated protein 1 0.0093 0.1592 0.5017
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0765 0.4742
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0453 0.0859
Brugia malayi nuclear receptor NHR-88 0.0014 0.0172 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0453 0.0859
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0068 0.1151 0.3625
Trichomonas vaginalis inositol monophosphatase, putative 0.0005 0.0005 0.001
Plasmodium falciparum cGMP-dependent protein kinase 0.0005 0.0012 0.0108
Onchocerca volvulus 0.0008 0.0059 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0453 0.0859
Entamoeba histolytica tyrosine kinase, putative 0.0006 0.0025 0.0133
Loa Loa (eye worm) hypothetical protein 0.0013 0.0158 0.0298
Loa Loa (eye worm) hypothetical protein 0.0014 0.0172 0.0325
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0498 0.3081
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0008 0.0028
Loa Loa (eye worm) hypothetical protein 0.003 0.0453 0.0859
Loa Loa (eye worm) hypothetical protein 0.0016 0.0202 0.0383
Echinococcus granulosus tyrosine protein kinase Src42A 0.0076 0.1299 0.4091
Echinococcus multilocularis NCK adaptor protein 0.0015 0.0193 0.0598
Schistosoma mansoni hypothetical protein 0.0166 0.2919 1
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0127 0.0788
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0013 0.0158 0.096
Loa Loa (eye worm) thyroid receptor interactor 0.0007 0.0055 0.0104
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0172 0.0532
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0078 0.0147
Echinococcus multilocularis Smad4 0.0008 0.0065 0.0194
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0603 0.7865
Schistosoma mansoni rotamase 0.0033 0.0512 0.1744
Loa Loa (eye worm) hypothetical protein 0.003 0.0453 0.0859
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0158 0.2761 0.2757
Brugia malayi SRC-1 0.0076 0.1299 0.2464
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0453 0.142
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0453 0.1542
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.033 0.1031
Entamoeba histolytica protein kinase domain containing protein 0.0005 0.0008 0.0028
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0013 0.0158 0.096
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0453 0.0859
Trypanosoma brucei beta lactamase 0.0063 0.1048 0.6507
Brugia malayi Spectrin alpha chain 0.0007 0.0055 0.0104
Echinococcus granulosus epidermal growth factor receptor kinase 0.0007 0.0055 0.0163
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.1609 0.507
Loa Loa (eye worm) steroid hormone receptor 0.0169 0.2967 0.5631
Mycobacterium ulcerans beta-lactamase 0.0038 0.0603 0.0598
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.033 0.0325
Echinococcus multilocularis signal transduction protein lnk realted 0.0008 0.0059 0.0174
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0709 0.2228
Trypanosoma cruzi hypothetical protein 0.0006 0.0033 0.0205
Echinococcus multilocularis tyrosine protein kinase HCK 0.0061 0.1027 0.3231
Echinococcus multilocularis kelch ECH associated protein 1 0.0093 0.1592 0.5017
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0033 0.0184
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0005 0.0005 0.001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0453 0.1542
Trichomonas vaginalis rotamase, putative 0.0032 0.0498 0.3081
Echinococcus multilocularis Protein son of sevenless 0.0006 0.0033 0.0093
Echinococcus multilocularis tyrosine protein kinase Blk 0.0069 0.1164 0.3666
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0202 0.0383
Loa Loa (eye worm) hypothetical protein 0.0014 0.0172 0.0325
Brugia malayi hypothetical protein 0.0036 0.0569 0.1078
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0055 0.0104
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0008 0.0059 0.0189
Echinococcus granulosus tyrosine protein kinase Src42A 0.0067 0.1126 0.3544
Onchocerca volvulus 0.0008 0.0059 0.0105
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.013 0.2269 0.2265
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0008 0.0059 0.0189
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0638 0.121
Onchocerca volvulus 0.003 0.0453 0.0854
Schistosoma mansoni Smad4 0.0008 0.0065 0.021
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0005 0.0012 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0005 0.0012 0.0028
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0007 0.0055 0.0163
Onchocerca volvulus Inositol monophosphatase 3 homolog 0.0005 0.0005 0.0003
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0076 0.1299 0.4091
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0008 0.0028
Mycobacterium ulcerans lipase LipD 0.0038 0.0603 0.0598
Trypanosoma cruzi mitochondrial protein 99, putative 0.0005 0.0003 0.0021
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.0005 0.0005 0.0031
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0005 0.0003 0.0021
Onchocerca volvulus 0.0038 0.0603 0.1139
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0005 0.0003 0.0006
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0008 0.0028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0172 0.0532
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0005 0.0003 0.0021
Brugia malayi ecdysteroid receptor 0.003 0.0453 0.0859
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0127 0.0768
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0006 0.0033 0.0184
Brugia malayi hypothetical protein 0.0014 0.0172 0.0325
Entamoeba histolytica SH2-protein kinase domain containing protein 0.001 0.0097 0.0585
Loa Loa (eye worm) hypothetical protein 0.0038 0.0603 0.1144
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0008 0.0059 0.0174
Brugia malayi Protein kinase domain containing protein 0.0006 0.0025 0.0046
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0006
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0172 0.032
Loa Loa (eye worm) hypothetical protein 0.0013 0.0158 0.0298
Entamoeba histolytica protein kinase, putative 0.0005 0.0008 0.0028
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0453 0.1542
Entamoeba histolytica protein kinase, putative 0.0005 0.0008 0.0028
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0008 0.0059 0.0189
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0055 0.0104
Brugia malayi Protein kinase domain containing protein 0.001 0.0097 0.0184
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0067 0.1126 0.3544
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0453 0.142
Brugia malayi conserved hypotetical protein 0.0014 0.0172 0.0325
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0005 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0055 0.0322
Leishmania major hypothetical protein, conserved 0.0022 0.0314 0.1937
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0076 0.1299 0.4091
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.033 0.2051
Brugia malayi Egg laying defective protein 4 0.0005 0.0012 0.0021
Leishmania major hypothetical protein, conserved 0.0013 0.0158 0.096
Echinococcus multilocularis tyrosine protein kinase shark 0.001 0.0097 0.0296
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0003 0.0006
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0005 0.0003 0.0021
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0172 0.0532
Brugia malayi MH2 domain containing protein 0.0008 0.0065 0.0122
Schistosoma mansoni adapter molecule crk 0.0015 0.0193 0.065
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0603 0.3748
Loa Loa (eye worm) protein-tyrosine kinase 0.0007 0.0055 0.0104
Schistosoma mansoni inositol monophosphatase 0.0045 0.0724 0.2472
Echinococcus granulosus geminin 0.0166 0.2919 0.9209
Brugia malayi ecdysone receptor 0.0014 0.0172 0.0325
Brugia malayi cell division control protein 2 homolog 0.0044 0.0709 0.1345
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0013 0.0158 0.0487
Brugia malayi Src substrate cortactin 0.0007 0.0055 0.0104
Schistosoma mansoni hypothetical protein 0.0166 0.2919 1
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0008 0.0028
Entamoeba histolytica hypothetical protein, conserved 0.0007 0.0055 0.0322
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0033 0.0184
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0127 0.0788
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0078 0.0256
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0008 0.0059 0.011
Onchocerca volvulus 0.0297 0.5268 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0453 0.1542
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0008 0.0059 0.011
Brugia malayi hypothetical protein 0.0008 0.0059 0.011
Leishmania major hypothetical protein, conserved 0.0038 0.0603 0.3734
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1609 1
Brugia malayi RasGEF domain containing protein 0.0006 0.0033 0.0062
Onchocerca volvulus 0.0038 0.0603 0.1139
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0202 0.0681
Trypanosoma cruzi mitochondrial protein 99, putative 0.0005 0.0003 0.0021
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0172 0.0325
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0013 0.0158 0.0487
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0603 0.3734
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0005 0.0005 0.0005
Toxoplasma gondii TIM10 family protein, putative 0.0047 0.0766 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0076 0.1299 0.4091
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0076 0.1299 0.4091
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0008 0.0059 0.0174
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0078 0.0147
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0013 0.0158 0.096
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0172 0.0532
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0007 0.0055 0.0163
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0044 0.0709 0.4395
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0638 0.8326
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0009 0.008 0.048
Brugia malayi SH3 domain containing protein 0.0007 0.0055 0.0104
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0033 0.0184
Giardia lamblia Kinase, PLK 0.0094 0.1609 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0172 0.0325
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.033 0.2034
Mycobacterium tuberculosis Probable monophosphatase 0.0005 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0009 0.0078 0.0147
Trichomonas vaginalis rotamase, putative 0.0033 0.0512 0.3167
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0006 0.0033 0.0093
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0065 0.0194
Mycobacterium ulcerans hypothetical protein 0.0038 0.0603 0.0598
Echinococcus granulosus tyrosine protein kinase Fyn 0.0076 0.1299 0.4091
Loa Loa (eye worm) TK protein kinase 0.0069 0.1164 0.2209
Loa Loa (eye worm) hypothetical protein 0.0014 0.0172 0.0325
Echinococcus granulosus NCK adaptor protein 0.0015 0.0193 0.0598
Echinococcus multilocularis Kelch repeat type 1 0.0093 0.1597 0.5032
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0193 0.0365
Echinococcus granulosus fch and double sh3 domains protein 2 0.0007 0.0055 0.0163
Schistosoma mansoni hypothetical protein 0.0008 0.0059 0.0189
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0078 0.0236
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0006 0.0033 0.0056
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0069 0.1164 0.3666
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0498 0.3081
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.013 0.2269 0.2266
Schistosoma mansoni hypothetical protein 0.0005 0.0005 0.0006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0453 0.0859
Entamoeba histolytica hypothetical protein 0.0007 0.0055 0.0322
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0044 0.0709 0.9256
Loa Loa (eye worm) hypothetical protein 0.0038 0.0603 0.1144
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.033 0.1031
Brugia malayi nuclear receptor NHR-88 0.003 0.0453 0.0859
Schistosoma mansoni tyrosine kinase 0.001 0.0097 0.0322
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0078 0.0147
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0008 0.0028
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0603 0.3734
Entamoeba histolytica hypothetical protein 0.0035 0.0557 0.3451
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0008 0.0059 0.0105
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0078 0.0236
Echinococcus multilocularis SH2 domain containing protein 7 0.0008 0.0059 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0453 0.0859
Schistosoma mansoni hypothetical protein 0.0093 0.1597 0.5464
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0498 0.3081
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0005 0.0003 0.0021
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0008 0.0028
Brugia malayi hypothetical protein 0.001 0.0097 0.0184
Plasmodium vivax protein kinase Crk2 0.0044 0.0709 0.9256
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0603 0.3734
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0008 0.0028
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0172 0.0325
Schistosoma mansoni dreadlocks/dock 0.0007 0.0055 0.0177
Mycobacterium tuberculosis Monophosphatase CysQ 0.0005 0.0005 0.0002
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0172 0.0325
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0603 0.06
Loa Loa (eye worm) hypothetical protein 0.0009 0.0078 0.0147
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0005 0.0003 0.0021
Echinococcus granulosus smad 0.0008 0.0065 0.0194
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0603 0.06
Entamoeba histolytica protein kinase, putative 0.0005 0.0008 0.0028
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0013 0.0158 0.096
Mycobacterium leprae Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase) 0.0013 0.0158 0.0153
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0724 0.4502
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0033 0.0062
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1609 1
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1609 1
Entamoeba histolytica protein kinase, putative 0.0007 0.0055 0.0322
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0013 0.0158 0.098
Entamoeba histolytica tyrosine kinase, putative 0.0006 0.0025 0.0133
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0013 0.0158 0.098
Schistosoma mansoni tensin 0.0008 0.0059 0.0189
Schistosoma mansoni myo inositol monophosphatase 0.0005 0.0005 0.0006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0453 0.142
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0709 0.1345
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0127 0.0768
Echinococcus multilocularis c src tyrosine kinase 0.0017 0.0232 0.0721
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0097 0.0184
Entamoeba histolytica hypothetical protein 0.0035 0.0557 0.3451
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0033 0.0101
Brugia malayi cytokine inducible SH2-containing protein 5 0.0008 0.0059 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0055 0.0322
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0076 0.1299 0.4091
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0097 0.0184
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0005 0.0012 0.0026
Brugia malayi RasGEF domain containing protein 0.0006 0.0033 0.0062
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0162 0.0308
Schistosoma mansoni tsg101-related 0.0046 0.0758 0.2587
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0709 0.2228
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0603 0.3734
Plasmodium falciparum protein kinase 5 0.0044 0.0709 0.9256
Loa Loa (eye worm) Smad1 0.0008 0.0065 0.0122
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0127 0.0788
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0097 0.0184
Echinococcus granulosus kelch ECH associated protein 1 like 0.0093 0.1592 0.5017
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0127 0.0788
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0033 0.0184
Brugia malayi Tyrosine-protein kinase abl-1 0.0017 0.0232 0.0439
Mycobacterium tuberculosis Conserved protein 0.0038 0.0603 0.06
Echinococcus multilocularis SH2 motif 0.0008 0.0059 0.0174
Echinococcus multilocularis muscleblind protein 1 0.018 0.317 1
Trypanosoma brucei cdc2-related kinase 1 0.0044 0.0709 0.4395
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0172 0.0532
Loa Loa (eye worm) hypothetical protein 0.0013 0.0158 0.0298
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0172 0.0325
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0008 0.0028
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1609 1
Entamoeba histolytica hypothetical protein 0.0005 0.0008 0.0028
Trypanosoma cruzi Wee1-like protein kinase, putative 0.0056 0.0937 0.5827
Echinococcus multilocularis geminin 0.0166 0.2919 0.9209
Schistosoma mansoni eps8-related protein 0.0007 0.0055 0.0177
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0172 0.0325
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0008 0.0028
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0724 0.449
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0013 0.0158 0.2023
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0638 0.8326
Giardia lamblia Hypothetical protein 0.0005 0.0005 0.001
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0013 0.0158 0.096
Loa Loa (eye worm) DR-78 0.0014 0.0172 0.0325
Onchocerca volvulus 0.0008 0.0059 0.0105
Schistosoma mansoni nuclear hormone receptor 0.003 0.0453 0.1542
Entamoeba histolytica protein kinase, putative 0.0005 0.0008 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0453 0.0859
Echinococcus granulosus expressed protein 0.0007 0.0055 0.0163
Loa Loa (eye worm) hypothetical protein 0.0297 0.5268 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0453 0.142
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0008 0.0028
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0127 0.0788
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0709 0.4395
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative 0.0005 0.0005 0.001
Onchocerca volvulus 0.0007 0.0055 0.0098
Echinococcus granulosus Protein son of sevenless 0.0006 0.0033 0.0093
Schistosoma mansoni growth factor receptor-bound protein 0.0015 0.0193 0.065
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0027 0.0082
Mycobacterium tuberculosis Conserved protein 0.0038 0.0603 0.06
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0097 0.0184
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0055 0.0343
Entamoeba histolytica BAR/SH3 domain containing protein 0.0007 0.0055 0.0322
Echinococcus multilocularis growth factor receptor bound protein 2 0.0015 0.0193 0.0598
Loa Loa (eye worm) hypothetical protein 0.003 0.0453 0.0859
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0094 0.031
Brugia malayi hypothetical protein 0.0035 0.0557 0.1057
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.1609 0.507
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.064 0.0637
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0005 0.0003 0.0006
Echinococcus granulosus SH2 motif 0.0008 0.0059 0.0174
Brugia malayi beta-lactamase family protein 0.0038 0.0603 0.1144
Brugia malayi nuclear receptor RXR 0.0014 0.0172 0.0325
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0005 0.0003 0.0006
Brugia malayi N-terminal motif family protein 0.0177 0.3115 0.5913
Onchocerca volvulus 0.0007 0.0055 0.0098
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0453 0.142
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0557 0.175
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0172 0.0532
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0007 0.0055 0.0104
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0007 0.0055 0.0163
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0766 1
Schistosoma mansoni tyrosine kinase 0.001 0.0097 0.0322
Schistosoma mansoni nuclear receptor 0.0014 0.0172 0.0578
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0005 0.0003 0.0021
Entamoeba histolytica hypothetical protein 0.0007 0.0055 0.0322
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0013 0.0158 0.2023
Echinococcus granulosus hypothetical protein 0.0008 0.0059 0.0174
Loa Loa (eye worm) hypothetical protein 0.0008 0.0059 0.011
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.0101 0.0625
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0013 0.0158 0.0293
Entamoeba histolytica hypothetical protein 0.0005 0.0008 0.0028
Onchocerca volvulus 0.0014 0.0172 0.032
Loa Loa (eye worm) hypothetical protein 0.0016 0.0202 0.0383
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0097 0.0184
Echinococcus multilocularis SH2 motif 0.0008 0.0059 0.0174
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0008 0.0059 0.011
Brugia malayi STAT protein, DNA binding domain containing protein 0.0008 0.0059 0.011
Onchocerca volvulus 0.0013 0.0162 0.0302
Schistosoma mansoni vav2 0.0008 0.0059 0.0189
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.033 0.0625
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0008 0.0059 0.0174
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0007 0.0055 0.0177
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0078 0.0256
Loa Loa (eye worm) AGC/PKG protein kinase 0.0005 0.0012 0.0021
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0006 0.0033 0.0093
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0007 0.0055 0.0163
Entamoeba histolytica hypothetical protein, conserved 0.0007 0.0055 0.0322
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0603 0.3734
Schistosoma mansoni hypothetical protein 0.0008 0.0059 0.0189
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0013 0.0158 0.0487
Brugia malayi Fes/CIP4 homology domain containing protein 0.0007 0.0055 0.0104
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0008 0.0059 0.011
Entamoeba histolytica hypothetical protein 0.0007 0.0055 0.0322
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0453 0.142
Schistosoma mansoni dynamin-associated protein 0.0007 0.0055 0.0177
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase GlpD2 0.0013 0.0158 0.0153
Onchocerca volvulus 0.001 0.0102 0.0187
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0008 0.0028
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0006
Echinococcus multilocularis Spectrin alpha actinin 0.0007 0.0055 0.0163
Trichomonas vaginalis hypothetical protein 0.0033 0.052 0.3219
Loa Loa (eye worm) hypothetical protein 0.0008 0.0059 0.011
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1609 1
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0172 0.0578
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0453 0.0859
Mycobacterium ulcerans thiamine biosynthesis oxidoreductase ThiO 0.0013 0.0158 0.0153
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0008 0.0059 0.0174
Brugia malayi Protein kinase domain containing protein 0.001 0.0097 0.0184
Echinococcus granulosus FTZ F1 alpha 0.003 0.0453 0.142
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0006 0.0033 0.0093
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0202 0.0383
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0453 0.0854
Entamoeba histolytica protein kinase, putative 0.0005 0.0008 0.0028
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase 0.0013 0.0158 0.0153
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0638 0.121
Chlamydia trachomatis D-amino acid dehydrogenase 0.0013 0.0158 1
Trypanosoma cruzi hypothetical protein 0.0006 0.0033 0.0205
Echinococcus granulosus cGMP dependent protein kinase 1 0.0005 0.0012 0.0026
Onchocerca volvulus 0.001 0.0097 0.0178
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0013 0.0158 0.098
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0033 0.0184
Brugia malayi hypothetical protein 0.0016 0.0202 0.0383
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.033 0.2034
Echinococcus granulosus intersectin 2 0.0007 0.0055 0.0163
Trypanosoma brucei cdc2-related kinase 3 0.0044 0.0709 0.4395
Echinococcus granulosus endophilin A3 0.0007 0.0055 0.0163
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0003 0.0006
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0013 0.0158 0.098
Toxoplasma gondii hypothetical protein 0.0005 0.0005 0.0021
Brugia malayi steroid hormone receptor 0.0169 0.2967 0.5631
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0015 0.0193 0.065
Brugia malayi SH2 domain containing protein 0.0008 0.0059 0.011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0078 0.0147
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0709 0.242
Schistosoma mansoni Dab2-interacting protein-like 0.0007 0.0055 0.0177
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0145 0.2524 0.2522
Echinococcus granulosus expressed conserved protein 0.0008 0.0059 0.0174
Brugia malayi DIX domain containing protein 0.0009 0.0078 0.0147
Echinococcus multilocularis SHC transforming protein 3 0.0008 0.0059 0.0174
Schistosoma mansoni GTPase activating protein 0.0008 0.0059 0.0189
Brugia malayi SH2 domain containing protein 0.001 0.0097 0.0184
Entamoeba histolytica tyrosine kinase, putative 0.0006 0.0025 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0055 0.0322
Echinococcus multilocularis smad 0.0008 0.0065 0.0194
Onchocerca volvulus 0.0006 0.0033 0.0056
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0005 0.0006 0.001
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.033 0.2034
Mycobacterium leprae Possible thiamine biosynthesis oxidoreductase ThiO 0.0013 0.0158 0.0153
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0033 0.0184
Brugia malayi hypothetical protein 0.0016 0.0202 0.0383
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0076 0.1299 0.4091
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0033 0.0184
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0127 0.0788
Loa Loa (eye worm) hypothetical protein 0.0008 0.0059 0.011
Onchocerca volvulus 0.0009 0.0077 0.014
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0013 0.0158 0.096
Brugia malayi SH2 domain containing protein 0.0008 0.0059 0.011
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.0314 0.1954
Brugia malayi CCR4 0.0005 0.0006 0.001
Schistosoma mansoni SH2A 0.0008 0.0059 0.0189
Echinococcus granulosus Spectrin alpha actinin 0.0007 0.0055 0.0163
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0172 0.0532
Echinococcus multilocularis expressed protein 0.0007 0.0055 0.0163
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0017 0.0232 0.0783
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0453 0.1542
Schistosoma mansoni dishevelled 0.0009 0.0078 0.0256
Brugia malayi MH2 domain containing protein 0.0117 0.2033 0.3859
Schistosoma mansoni dishevelled 0.0009 0.0078 0.0256
Toxoplasma gondii exonuclease III APE 0.0023 0.033 0.4283
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0127 0.0788
Loa Loa (eye worm) hypothetical protein 0.0014 0.0172 0.0325
Echinococcus granulosus suppressor of cytokine signaling 7 0.0008 0.0059 0.0174
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.1609 1
Schistosoma mansoni formin binding protein and related proteins 0.0007 0.0055 0.0177
Entamoeba histolytica cysteine surface protein, putative 0.0006 0.0025 0.0133
Leishmania major hypothetical protein, conserved 0.0007 0.0055 0.0322
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0008 0.0028
Loa Loa (eye worm) hypothetical protein 0.003 0.0453 0.0859
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0638 0.8326
Echinococcus granulosus tyrosine protein kinase Blk 0.0069 0.1164 0.3666
Brugia malayi hypothetical protein 0.0068 0.1151 0.2185
Echinococcus granulosus tyrosine protein kinase Fps85D 0.001 0.0097 0.0296
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0078 0.0142
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0453 0.142
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0008 0.0028
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0512 0.0971
Entamoeba histolytica SH2 domain containing protein 0.0008 0.0059 0.0344
Schistosoma mansoni tyrosine kinase 0.0017 0.0232 0.0783
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.0709 0.4407
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0603 0.1893
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0078 0.0147
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1609 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0003 0.0006
Loa Loa (eye worm) STAT protein 0.0008 0.0059 0.011
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0055 0.0104
Entamoeba histolytica protein kinase domain containing protein 0.0005 0.0008 0.0028
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0007 0.0055 0.0177
Entamoeba histolytica protein kinase domain containing protein 0.0005 0.0008 0.0028
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0453 0.0854
Leishmania major hypothetical protein, conserved 0.0013 0.0158 0.096
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0007 0.0055 0.0163
Loa Loa (eye worm) hypothetical protein 0.0014 0.0172 0.0325
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0101 0.1274
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0008 0.0059 0.0174
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0638 0.121
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0013 0.0158 0.098
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0009
Schistosoma mansoni signal transduction protein lnk-related 0.0008 0.0059 0.0189
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0724 0.449
Entamoeba histolytica tyrosine kinase, putative 0.0006 0.0025 0.0133
Echinococcus multilocularis transfer RNA-Ala 0.0007 0.0055 0.0163
Entamoeba histolytica protein kinase, putative 0.0005 0.0008 0.0028
Brugia malayi SH2 domain containing protein 0.0008 0.0059 0.011
Trichomonas vaginalis esterase, putative 0.0038 0.0603 0.3734
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0005 0.0003 0.0006
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.0013 0.0158 0.0154
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0005 0.0003 0.0021
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0007 0.0055 0.0104
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0603 0.0598
Echinococcus granulosus son of sevenless 1 0.0006 0.0033 0.0093
Brugia malayi Smad1 0.0008 0.0065 0.0122
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0724 0.449
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0005 0.0003 0.0021
Loa Loa (eye worm) hypothetical protein 0.0008 0.0059 0.011
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0008 0.0059 0.011
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0172 0.0325
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0498 0.3095
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0033 0.0184
Brugia malayi nuclear receptor NHR-67 0.0014 0.0172 0.0325
Entamoeba histolytica hypothetical protein 0.0007 0.0055 0.0322
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0047 0.0766 0.1453
Echinococcus granulosus tyrosine kinase 0.001 0.0097 0.0296
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1609 1
Brugia malayi hypothetical protein 0.0297 0.5268 1
Schistosoma mansoni suppressor of cytokine signaling 0.0008 0.0059 0.0189
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0453 0.1542
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0005 0.0003 0.0021
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0172 0.0578
Schistosoma mansoni suppressor of cytokine signaling 0.0008 0.0059 0.0189
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0453 0.142
Brugia malayi Variant SH3 domain containing protein 0.0008 0.0059 0.011
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0008 0.0059 0.0189
Loa Loa (eye worm) hypothetical protein 0.018 0.317 0.6016
Entamoeba histolytica hypothetical protein 0.0007 0.0055 0.0322
Echinococcus granulosus tyrosine protein kinase HCK 0.0061 0.1027 0.3231
Echinococcus granulosus SH2 motif 0.0008 0.0059 0.0174
Trypanosoma brucei inositol polyphosphate 1-phosphatase, putative 0.0005 0.0005 0.001
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0033 0.0101
Brugia malayi Peripheral plasma membrane protein CASK 0.0007 0.0055 0.0104
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0063 0.1048 0.1043
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0453 0.1542
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0078 0.0236
Entamoeba histolytica tyrosine kinase, putative 0.0006 0.0025 0.0133
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0724 0.449
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0127 0.0768
Echinococcus granulosus muscleblind protein 0.018 0.317 1
Onchocerca volvulus 0.001 0.0097 0.0178
Toxoplasma gondii hypothetical protein 0.0013 0.0158 0.2023
Echinococcus multilocularis expressed protein 0.0033 0.0512 0.1606
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0453 0.142
Schistosoma mansoni tyrosine kinase 0.0076 0.1299 0.4442
Trichomonas vaginalis inositol monophosphatase, putative 0.0005 0.0005 0.001
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0056 0.0937 0.5818
Echinococcus granulosus expressed protein 0.0047 0.0766 0.2407
Schistosoma mansoni hypothetical protein 0.0005 0.0005 0.0006
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0453 0.142
Schistosoma mansoni tsg101-related 0.0057 0.0946 0.3231
Brugia malayi protein-tyrosine kinase 0.0069 0.1164 0.2209
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0453 0.0859
Loa Loa (eye worm) hypothetical protein 0.0014 0.0172 0.0325
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0078 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0512 0.3167
Loa Loa (eye worm) hypothetical protein 0.0007 0.0055 0.0104
Loa Loa (eye worm) hypothetical protein 0.0014 0.0172 0.0325
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0013 0.0158 0.096
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0005 0.0005 0.001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0005 0.0003 0.0021
Schistosoma mansoni tensin 0.0008 0.0059 0.0189
Loa Loa (eye worm) hypothetical protein 0.003 0.0453 0.0859
Schistosoma mansoni tensin-related 0.0008 0.0059 0.0189
Echinococcus granulosus tyrosine protein kinase Fyn 0.0076 0.1299 0.4091
Echinococcus granulosus growth factor receptor bound protein 2 0.0015 0.0193 0.0598
Echinococcus granulosus N chimaerin 0.0008 0.0059 0.0174
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0008 0.0028
Entamoeba histolytica hypothetical protein 0.0035 0.0557 0.3451
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0172 0.0325
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0069 0.1164 0.3666
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.033 0.2034
Schistosoma mansoni growth factor receptor-bound protein 0.0015 0.0193 0.065
Brugia malayi Inositol monophosphatase family protein 0.0005 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0202 0.0383
Brugia malayi Inositol-1 0.0045 0.0724 0.1374
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0172 0.0578
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0006 0.0033 0.0205
Echinococcus multilocularis expressed protein 0.0047 0.0766 0.2407
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0453 0.142
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0007 0.0055 0.0163
Echinococcus granulosus src region 0.0007 0.0055 0.0163
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0709 0.4395
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0127 0.0788
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0557 0.19
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0007 0.0055 0.0163
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0003 0.0006
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0603 0.06
Echinococcus granulosus cGMP dependent protein kinase 0.0005 0.0012 0.0026
Schistosoma mansoni smad1 5 8 and 0.0008 0.0065 0.021
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0242 0.4278 0.4276
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0007 0.0055 0.0163
Brugia malayi N-terminal motif family protein 0.0006 0.0033 0.0062
Mycobacterium ulcerans lipoprotein LpqF 0.0063 0.1048 0.1043
Onchocerca volvulus 0.0038 0.0603 0.1139
Brugia malayi Protein kinase domain containing protein 0.001 0.0097 0.0184
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0078 0.0236
Schistosoma mansoni serine/threonine protein kinase 0.0005 0.0012 0.0028
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0172 0.032
Loa Loa (eye worm) hypothetical protein 0.0006 0.0033 0.0062
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0202 0.0627
Echinococcus multilocularis muscleblind protein 0.018 0.317 1
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0078 0.0236
Echinococcus multilocularis cyclin dependent kinase 5 0.0044 0.0709 0.2228
Schistosoma mansoni cell polarity protein 0.0007 0.0055 0.0177
Brugia malayi hypothetical protein 0.0009 0.0078 0.0147
Entamoeba histolytica protein kinase, putative 0.0009 0.008 0.048
Onchocerca volvulus 0.0007 0.0055 0.0098
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0158 0.2761 0.2757
Trypanosoma cruzi Wee1-like protein kinase, putative 0.0056 0.0937 0.5827
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.001 0.0097 0.0296
Echinococcus granulosus tyrosine protein kinase shark 0.001 0.0097 0.0296
Brugia malayi Myosin tail family protein 0.0007 0.0055 0.0104
Schistosoma mansoni hypothetical protein 0.0007 0.0055 0.0177
Entamoeba histolytica tyrosine kinase, putative 0.0006 0.0025 0.0133
Loa Loa (eye worm) hypothetical protein 0.0007 0.0055 0.0104
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.0033 0.0101
Onchocerca volvulus 0.0007 0.0055 0.0098
Toxoplasma gondii ABC1 family protein 0.0038 0.0603 0.7865
Brugia malayi Protein kinase domain containing protein 0.001 0.0097 0.0184
Echinococcus multilocularis cyclin dependent kinase 0.0044 0.0709 0.2228
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0453 0.0859
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0065 0.0122
Loa Loa (eye worm) hypothetical protein 0.0016 0.0202 0.0383
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0453 0.0859
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0709 0.242
Schistosoma mansoni tensin 0.0008 0.0059 0.0189
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.033 0.2051
Loa Loa (eye worm) hypothetical protein 0.0038 0.0603 0.1144
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.033 0.0625
Brugia malayi tRNA modification GTPase TrmE family protein 0.0008 0.0059 0.011
Trichomonas vaginalis ras GTP exchange factor, putative 0.0006 0.0033 0.0184
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0008 0.0059 0.0174
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0453 0.0859
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0076 0.1299 0.4091
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1609 0.5505
Echinococcus granulosus expressed protein 0.0033 0.0512 0.1606
Trypanosoma brucei wee1-like protein kinase 0.0056 0.0937 0.5818
Entamoeba histolytica tyrosine kinase, putative 0.0006 0.0025 0.0133
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0008 0.0059 0.0174
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.1609 0.3053
Leishmania major inositol polyphosphate 1-phosphatase, putative 0.0005 0.0005 0.001
Brugia malayi MH1 domain containing protein 0.0008 0.0065 0.0122
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0008 0.0059 0.0174
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0063 0.1048 0.1045
Echinococcus granulosus c src tyrosine kinase 0.0017 0.0232 0.0721
Loa Loa (eye worm) hypothetical protein 0.0038 0.0603 0.1144
Trichomonas vaginalis p67phox protein, putative 0.0007 0.0055 0.0322
Loa Loa (eye worm) guanylate kinase 0.0007 0.0055 0.0104
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0033 0.0184
Loa Loa (eye worm) hypothetical protein 0.018 0.317 0.6016
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.0314 0.1937
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0007 0.0055 0.0177
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.0709 0.4407
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0013 0.0158 0.0293
Echinococcus granulosus SH2 domain containing protein 7 0.0008 0.0059 0.0174
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0603 0.3734
Loa Loa (eye worm) TK/ABL protein kinase 0.001 0.0097 0.0184
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.0709 0.4407
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0172 0.0532
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0101 0.0605
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0172 0.0532
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0013 0.0158 0.0487
Schistosoma mansoni sorbin 0.0007 0.0055 0.0177
Loa Loa (eye worm) hypothetical protein 0.0014 0.0172 0.0325
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.1609 0.3049
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0005 0.0005 0.001
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.033 1
Brugia malayi RE18450p 0.0013 0.0158 0.0298
Schistosoma mansoni thyroid hormone receptor 0.003 0.0453 0.1542
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0603 0.1144
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0603 0.1144
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0008 0.0059 0.0174
Entamoeba histolytica unconventional myosin IB 0.0007 0.0055 0.0322
Trypanosoma brucei conserved protein 0.0007 0.0055 0.0322
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0005 0.0003 0.0006
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0453 0.142
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0453 0.0859
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0007 0.0055 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0453 0.0859
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0055 0.0322
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0603 0.0598
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0603 0.06
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0453 0.0859
Echinococcus multilocularis inositol monophosphatase 0.0005 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0172 0.0325
Echinococcus granulosus signal transduction protein lnk realted 0.0008 0.0059 0.0174
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0013 0.0158 0.0153
Leishmania major protein kinase, putative 0.0005 0.0012 0.0051
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0003 0.0006
Loa Loa (eye worm) SH2 domain-containing protein 0.0008 0.0059 0.011
Schistosoma mansoni tensin-related 0.0008 0.0059 0.0189
Schistosoma mansoni hypothetical protein 0.0035 0.0557 0.19
Brugia malayi Sex muscle abnormal protein 5 0.0015 0.0193 0.0365
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0172 0.0532
Loa Loa (eye worm) hypothetical protein 0.0008 0.0059 0.011
Entamoeba histolytica hypothetical protein 0.0011 0.0127 0.0768
Brugia malayi Inositol monophosphatase family protein 0.0005 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0007 0.0055 0.0104
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0005 0.0003 0.0021
Onchocerca volvulus Putative fad oxidoreductase 0.0013 0.0158 0.0293
Entamoeba histolytica hypothetical protein 0.0005 0.0008 0.0028
Echinococcus granulosus Smad4 0.0008 0.0065 0.0194
Schistosoma mansoni run and tbc1 domain containing 0.0007 0.0055 0.0177
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0453 0.1542
Loa Loa (eye worm) hypothetical protein 0.0007 0.0055 0.0104
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0097 0.0184
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0007 0.0055 0.0177
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0202 0.0681
Loa Loa (eye worm) hypothetical protein 0.001 0.0097 0.0184
Echinococcus multilocularis kelch ECH associated protein 1 0.0093 0.1592 0.5017
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0055 0.0104
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0127 0.0788
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0097 0.0184
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0766 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0033 0.0184
Loa Loa (eye worm) hypothetical protein 0.003 0.0453 0.0859
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0044 0.0709 0.1345
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0172 0.0325
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0065 0.021
Loa Loa (eye worm) hypothetical protein 0.003 0.0453 0.0859
Echinococcus multilocularis tensin 0.0008 0.0059 0.0174
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0709 0.4395
Echinococcus multilocularis endophilin A3 0.0007 0.0055 0.0163
Echinococcus multilocularis N chimaerin 0.0008 0.0059 0.0174
Brugia malayi hypothetical protein 0.0036 0.0569 0.1078
Onchocerca volvulus 0.0009 0.0078 0.0142
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.0709 0.4395
Loa Loa (eye worm) hypothetical protein 0.0008 0.0059 0.011
Entamoeba histolytica protein kinase, putative 0.0005 0.0008 0.0028
Schistosoma mansoni NAD dehydrogenase 0.0013 0.0158 0.0529
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0065 0.0194
Loa Loa (eye worm) hypothetical protein 0.0008 0.0059 0.011
Schistosoma mansoni coup transcription factor 0.003 0.0453 0.1542
Entamoeba histolytica BAR/SH3 domain containing protein 0.0007 0.0055 0.0322
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0078 0.0147
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0033 0.0062
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0013 0.0158 0.096
Toxoplasma gondii hypothetical protein 0.0009 0.0078 0.0979
Schistosoma mansoni inositol monophosphatase 0.0045 0.0724 0.2472
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0172 0.0578
Echinococcus multilocularis 0.0008 0.0059 0.0174
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1609 1
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0013 0.0158 0.098
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0724 0.449
Echinococcus granulosus cyclin dependent kinase 1 0.0044 0.0709 0.2228
Loa Loa (eye worm) hypothetical protein 0.0068 0.1151 0.2185
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0033 0.0184
Schistosoma mansoni zinc finger protein 0.0014 0.0172 0.0578
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0065 0.0194
Onchocerca volvulus 0.0008 0.0059 0.0105
Loa Loa (eye worm) hypothetical protein 0.0008 0.0059 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0172 0.0325
Entamoeba histolytica tyrosine kinase, putative 0.0006 0.0025 0.0133
Entamoeba histolytica protein kinase, putative 0.0061 0.1027 0.6377
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0005 0.0005 0.001
Onchocerca volvulus 0.0008 0.0059 0.0105
Schistosoma mansoni tyrosine kinase 0.0076 0.1299 0.4442
Echinococcus multilocularis tyrosine kinase 0.001 0.0097 0.0296
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0724 0.0719
Entamoeba histolytica protein kinase, putative 0.0006 0.0025 0.0133
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0068 0.1151 0.3625
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0033 0.0101
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0177 0.3115 0.591
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0638 0.2004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0453 0.142
Echinococcus multilocularis ras GTP exchange factor 0.0006 0.0033 0.0093
Entamoeba histolytica protein kinase domain containing protein 0.0005 0.0008 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0453 0.0859
Mycobacterium leprae Probable lipase LipE 0.0038 0.0603 0.0598
Loa Loa (eye worm) hypothetical protein 0.004 0.0638 0.121
Schistosoma mansoni ap endonuclease 0.0023 0.033 0.112
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0453 0.1542
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0097 0.0184
Brugia malayi SH2 domain containing protein 0.0008 0.0059 0.011
Brugia malayi N-terminal motif family protein 0.0006 0.0033 0.0062
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.033 0.2034
Brugia malayi Variant SH3 domain containing protein 0.0008 0.0059 0.011
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0172 0.0325
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0453 0.0859
Brugia malayi Protein kinase domain containing protein 0.001 0.0097 0.0184
Brugia malayi RasGEF domain containing protein 0.0006 0.0033 0.0062
Entamoeba histolytica tyrosine kinase, putative 0.0006 0.0025 0.0133
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0013 0.0158 0.098
Schistosoma mansoni nck2/grb4 0.0015 0.0193 0.065
Schistosoma mansoni nuclear receptor 0.0014 0.0172 0.0578
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0008 0.0028
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0005 0.0003 0.0021
Brugia malayi Protein kinase domain containing protein 0.0044 0.0709 0.1345
Echinococcus granulosus kelch ECH associated protein 1 like 0.0093 0.1592 0.5017
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0101 0.0625
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0078 0.0236
Echinococcus multilocularis SH2 motif 0.0008 0.0059 0.0174
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0006 0.0033 0.0184
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0724 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0453 0.0859
Schistosoma mansoni ap endonuclease 0.0023 0.033 0.112
Echinococcus multilocularis son of sevenless 1 0.0006 0.0033 0.0093
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0193 0.0365
Onchocerca volvulus Putative cortactin 0.0007 0.0055 0.0098
Brugia malayi beta-lactamase family protein 0.0038 0.0603 0.1144
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0008 0.0059 0.0174
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.0365
Entamoeba histolytica hypothetical protein 0.0011 0.0127 0.0768
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0078 0.0236
Entamoeba histolytica hypothetical protein 0.0006 0.0033 0.0184
Entamoeba histolytica hypothetical protein 0.0007 0.0055 0.0322
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0047 0.0766 0.2614
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0005 0.0012 0.0108
Schistosoma mansoni ras GTP exchange factor 0.0006 0.0033 0.0101
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0005 0.0006 0.0013
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0007 0.0055 0.0163
Brugia malayi nuclear hormone receptor 0.003 0.0453 0.0859
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0055 0.0322
Entamoeba histolytica tyrosine kinase, putative 0.0006 0.0025 0.0133
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.1609 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0127 0.0788
Loa Loa (eye worm) p53BP2 0.0007 0.0055 0.0104
Entamoeba histolytica protein kinase domain containing protein 0.0005 0.0008 0.0028
Schistosoma mansoni thyroid hormone receptor 0.003 0.0453 0.1542
Brugia malayi Muscleblind-like protein 0.018 0.317 0.6016
Schistosoma mansoni hypothetical protein 0.004 0.0638 0.2177
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0078 0.0236
Echinococcus granulosus cyclin dependent kinase 0.0044 0.0709 0.2228
Brugia malayi SH2 domain containing protein 0.0008 0.0059 0.011
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.2033 0.3859
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0076 0.1299 0.4091
Echinococcus granulosus cyclin dependent kinase 5 0.0044 0.0709 0.2228
Echinococcus granulosus tyrosine protein kinase Srms 0.001 0.0097 0.0296
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0008 0.0028
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0709 0.4395
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0724 0.4502
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0724 0.2276
Brugia malayi cDNA sequence BC016226 0.0013 0.0158 0.0298
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0101 0.0605
Schistosoma mansoni smad 0.0008 0.0065 0.021
Brugia malayi MH1 domain containing protein 0.0008 0.0065 0.0122
Echinococcus granulosus cGMP dependent protein kinase 1 0.0005 0.0012 0.0026
Schistosoma mansoni sorting nexin 0.0007 0.0055 0.0177
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0013 0.0158 0.2023
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0065 0.0122
Entamoeba histolytica protein kinase domain containing protein 0.0005 0.0008 0.0028
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0127 0.0788
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0065 0.0194
Echinococcus granulosus SHC transforming protein 3 0.0008 0.0059 0.0174
Schistosoma mansoni dep domain containing protein 0.0009 0.0078 0.0256
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.0005 0.0005 0.0031
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0007 0.0055 0.0343
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0033 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0453 0.0859
Brugia malayi protein-tyrosine kinase 0.0007 0.0055 0.0104
Brugia malayi hypothetical protein 0.0014 0.0172 0.0325
Entamoeba histolytica hypothetical protein 0.0035 0.0557 0.3451
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0453 0.142
Echinococcus granulosus inositol monophosphatase 0.0005 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0043 0.0687 0.1304
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.033 0.4283
Echinococcus multilocularis nostrin 0.0007 0.0055 0.0163
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0078 0.0236
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0603 0.2056
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0172 0.0532
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0724 0.9456
Schistosoma mansoni fad oxidoreductase 0.0013 0.0158 0.0529
Brugia malayi MH2 domain containing protein 0.0008 0.0065 0.0122
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0007 0.0055 0.0163
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0453 0.142
Schistosoma mansoni d-amino acid oxidase 0.0158 0.2761 0.9458
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0453 0.142
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0055 0.0343
Loa Loa (eye worm) SH2 domain-containing protein 0.0008 0.0059 0.011
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0013 0.0158 0.0298
Loa Loa (eye worm) SH2 domain-containing protein 0.0008 0.0059 0.011
Loa Loa (eye worm) hypothetical protein 0.0007 0.0055 0.0104
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0202 0.0627
Entamoeba histolytica hypothetical protein 0.0011 0.0127 0.0768
Brugia malayi Tensin 0.0008 0.0059 0.011
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0097 0.0184
Entamoeba histolytica hypothetical protein 0.0007 0.0055 0.0322
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0603 0.1893
Loa Loa (eye worm) beta-lactamase 0.0038 0.0603 0.1144
Schistosoma mansoni C-fyn 0.0007 0.0055 0.0177
Echinococcus multilocularis tyrosine protein kinase Abl 0.0017 0.0232 0.0721
Schistosoma mansoni fad oxidoreductase 0.0013 0.0158 0.0529
Entamoeba histolytica hypothetical protein, conserved 0.0006 0.0025 0.0133
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.0709 0.4407
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0006
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0603 0.06
Brugia malayi tailless protein 0.0014 0.0172 0.0325
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0603 0.06
Leishmania major myo-inositol-1 phosphatase, putative 0.0005 0.0005 0.001
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0013 0.0158 0.0298
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0013 0.0158 0.096
Brugia malayi SH2 domain containing protein 0.0008 0.0059 0.011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0453 0.142
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0033 0.0062
Brugia malayi Guanylate kinase family protein 0.0007 0.0055 0.0104
Schistosoma mansoni smad1 5 8 and 0.0008 0.0065 0.021
Loa Loa (eye worm) inositol-1 0.0045 0.0724 0.1374
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0055 0.0104
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0007 0.0055 0.0163
Echinococcus multilocularis tensin 0.0008 0.0059 0.0174
Echinococcus granulosus ras GTP exchange factor 0.0006 0.0033 0.0093
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0007 0.0055 0.0098
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0055 0.0343
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0603 0.06
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0008 0.0059 0.011
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0076 0.1299 0.4091
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.033 0.2034
Echinococcus granulosus tyrosine protein kinase Src64B 0.0076 0.1299 0.4091
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0044 0.0709 0.2228
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0015 0.0193 0.0365
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0603 0.0598
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0003 0.0006
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0076 0.1299 0.4091
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0453 0.0859
Echinococcus granulosus tyrosine protein kinase Lyn 0.0078 0.132 0.4159
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0127 0.0788
Loa Loa (eye worm) hypothetical protein 0.0008 0.0059 0.011
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0498 0.6488
Loa Loa (eye worm) hypothetical protein 0.003 0.0453 0.0859
Entamoeba histolytica hypothetical protein 0.0007 0.0055 0.0322
Loa Loa (eye worm) hypothetical protein 0.0016 0.0202 0.0383
Entamoeba histolytica protein kinase, putative 0.0005 0.0008 0.0028
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0009
Schistosoma mansoni tsg101-related 0.0057 0.0946 0.3231
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0008 0.0028
Brugia malayi hypothetical protein 0.0009 0.0078 0.0147
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0055 0.0104
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0033 0.0184
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0078 0.0236
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0512 0.0971
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0015 0.0193 0.0365
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0013 0.0158 0.0529
Echinococcus multilocularis tyrosine protein kinase ABL1 0.001 0.0097 0.0296
Schistosoma mansoni tyrosine kinase 0.0017 0.0232 0.0783
Echinococcus multilocularis intersectin 2 0.0007 0.0055 0.0163
Loa Loa (eye worm) hypothetical protein 0.0014 0.0172 0.0325
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.2033 0.3859
Schistosoma mansoni apoptosis stimulating of P53 0.0007 0.0055 0.0177
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0076 0.1299 0.4091
Echinococcus granulosus thyroid hormone receptor alpha 0.0154 0.2686 0.8471
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0055 0.0322
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0724 0.449
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0603 0.3748
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0765 0.4742
Loa Loa (eye worm) hypothetical protein 0.0177 0.3115 0.5913
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.033 0.3677
Loa Loa (eye worm) hypothetical protein 0.0006 0.0033 0.0062
Loa Loa (eye worm) hypothetical protein 0.0008 0.0059 0.011
Loa Loa (eye worm) hypothetical protein 0.0038 0.0603 0.1144
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0003 0.0006
Loa Loa (eye worm) TK protein kinase 0.0061 0.1027 0.1948
Brugia malayi nuclear hormone receptor 0.0014 0.0172 0.0325
Echinococcus granulosus SH2 domain containing adapter protein F 0.0008 0.0059 0.0174
Loa Loa (eye worm) hypothetical protein 0.0007 0.0055 0.0104
Loa Loa (eye worm) hypothetical protein 0.0158 0.2761 0.5241
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0453 0.0859
Mycobacterium tuberculosis Conserved protein 0.0038 0.0603 0.06
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0008 0.0059 0.0174
Schistosoma mansoni shc transforming protein 0.0008 0.0059 0.0189
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0047 0.0766 0.1453
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0013 0.0158 0.0529
Trypanosoma brucei polo-like protein kinase 0.0094 0.1609 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.001 0.0097 0.0296
Brugia malayi nuclear receptor RXR 0.0016 0.0202 0.0383
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0453 0.0854
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0046 0.0758 0.47
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0044 0.0709 0.4395
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0017 0.0232 0.0721
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0453 0.0859
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0008 0.0059 0.0105
Loa Loa (eye worm) hypothetical protein 0.0014 0.0172 0.0325
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0766 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.033 0.0327
Onchocerca volvulus 0.001 0.0097 0.0178
Leishmania major protein kinase, putative 0.0005 0.0012 0.0051
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0013 0.0158 0.0298
Entamoeba histolytica hypothetical protein 0.0011 0.0127 0.0768
Onchocerca volvulus 0.0006 0.0025 0.004
Schistosoma mansoni kinase 0.0048 0.0787 0.2686
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0006 0.0033 0.0093
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0076 0.1299 0.4091
Loa Loa (eye worm) hypothetical protein 0.0007 0.0055 0.0104
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0003 0.0006
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0709 0.4395
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1609 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0172 0.0578
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.033 0.4283
Schistosoma mansoni smad1 5 8 and 0.0008 0.0065 0.021
Onchocerca volvulus 0.001 0.0097 0.0178
Brugia malayi RhoGAP domain containing protein 0.0008 0.0059 0.011
Loa Loa (eye worm) hypothetical protein 0.0008 0.0059 0.011
Echinococcus granulosus suppressor of cytokine signaling 6 0.0008 0.0059 0.0174
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.0709 0.4395
Loa Loa (eye worm) hypothetical protein 0.0007 0.0055 0.0104
Echinococcus multilocularis expressed conserved protein 0.0005 0.0012 0.0026
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0724 0.2276
Echinococcus granulosus nostrin 0.0007 0.0055 0.0163
Trichomonas vaginalis ras GTP exchange factor, putative 0.0006 0.0033 0.0184
Loa Loa (eye worm) hypothetical protein 0.0008 0.0059 0.011
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0008 0.0059 0.0174
Schistosoma mansoni hypothetical protein 0.0007 0.0055 0.0177
Schistosoma mansoni pap-inositol-14-phosphatase 0.0005 0.0005 0.0006
Brugia malayi SH2 domain containing protein 0.0008 0.0059 0.011
Onchocerca volvulus 0.0008 0.0059 0.0105
Brugia malayi beta-lactamase 0.0038 0.0603 0.1144
Onchocerca volvulus 0.0014 0.0172 0.032
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.1609 0.3053
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0498 0.3095
Echinococcus multilocularis tyrosine protein kinase Srms 0.0069 0.1164 0.3666
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0007 0.0055 0.0322
Loa Loa (eye worm) SRC-1 0.0076 0.1299 0.2464
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0202 0.0383
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0055 0.0322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0453 0.0859
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0603 0.2056
Entamoeba histolytica protein kinase domain containing protein 0.0005 0.0008 0.0028
Onchocerca volvulus 0.001 0.0097 0.0178
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0056 0.0937 0.5818
Brugia malayi SH2 domain containing protein 0.001 0.0097 0.0184
Echinococcus granulosus tyrosine kinase 0.0069 0.1164 0.3666
Trypanosoma cruzi Wee1-like protein kinase, putative 0.0056 0.0937 0.5827

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) 3.1623 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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