Detailed information for compound 1365115

Basic information

Technical information
  • TDR Targets ID: 1365115
  • Name: 6-[(2-chlorophenyl)methyl]-5,7-dimethyl-[1,2, 4]triazolo[1,5-a]pyrimidine
  • MW: 272.733 | Formula: C14H13ClN4
  • H donors: 0 H acceptors: 3 LogP: 3.45 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nc2ncnn2c(c1Cc1ccccc1Cl)C
  • InChi: 1S/C14H13ClN4/c1-9-12(7-11-5-3-4-6-13(11)15)10(2)19-14(18-9)16-8-17-19/h3-6,8H,7H2,1-2H3
  • InChiKey: GEPHJXXBTDNCKA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(2-chlorobenzyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine
  • EU-0063306
  • MLS000522796
  • SMR000128062

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0181 0.1119 0.2773
Brugia malayi Pleckstrin Homology Domain 0.0043 0.0064 0.0064
Toxoplasma gondii casein kinase I 0.01 0.0495 0.3782
Plasmodium falciparum serine/threonine protein kinase 0.0075 0.0306 0.203
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.0903 0.2814
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0109 0.057 0.0566
Brugia malayi Immunoglobulin I-set domain containing protein 0.0232 0.1507 0.1507
Trichomonas vaginalis CMGC family protein kinase 0.0076 0.0311 0.1715
Brugia malayi Protein kinase domain containing protein 0.0045 0.0079 0.0079
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0204 0.1298 0.1294
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0079 0.0075
Loa Loa (eye worm) hypothetical protein 0.0137 0.0784 0.078
Echinococcus multilocularis tyrosine protein kinase HCK 0.0056 0.0158 0.0475
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0039 0.0027 0.008
Schistosoma mansoni protein kinase 0.0412 0.2892 0.9011
Schistosoma mansoni serine/threonine protein kinase 0.0164 0.0985 0.307
Trichomonas vaginalis CMGC family protein kinase 0.0165 0.0996 0.6544
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0142 0.0819 0.6473
Schistosoma mansoni rac gtpase activating protein 0.004 0.0039 0.0121
Toxoplasma gondii CMGC kinase, CK2 family 0.0091 0.0432 0.3259
Toxoplasma gondii AGC kinase 0.0065 0.0233 0.1608
Echinococcus multilocularis cyclin dependent kinase 0.0197 0.1243 0.3725
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0181 0.1119 0.3351
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.032 0.2186 0.2183
Trichomonas vaginalis AGC family protein kinase 0.0165 0.1 0.6574
Loa Loa (eye worm) SRC-1 0.009 0.0419 0.0416
Brugia malayi SRC-1 0.009 0.0419 0.0419
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0165 0.0996 0.7946
Loa Loa (eye worm) hypothetical protein 0.02 0.1265 0.1262
Brugia malayi probable protein kinase 0.0332 0.2278 0.2278
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0718 0.2237
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0058 0.0176 0.0436
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0063 0.0216 0.0646
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0209 0.1332 0.33
Loa Loa (eye worm) hypothetical protein 0.0133 0.0754 0.075
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0129 0.0718 0.0714
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0148 0.0867 0.0863
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0159 0.0947 0.2347
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0076 0.0311 0.2069
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0164 0.0985 0.2952
Trichomonas vaginalis CK1 family protein kinase 0.01 0.0495 0.301
Entamoeba histolytica protein kinase domain containing protein 0.019 0.1192 0.957
Echinococcus granulosus Glutaredoxin protein 5 0.0053 0.0136 0.0337
Schistosoma mansoni cell adhesion molecule 0.0045 0.0075 0.0232
Echinococcus granulosus expressed protein 0.0075 0.0306 0.0759
Trichomonas vaginalis CMGC family protein kinase 0.0197 0.1243 0.8287
Loa Loa (eye worm) hypothetical protein 0.004 0.0039 0.0035
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0165 0.0996 0.7897
Echinococcus granulosus dual specificity 0.0129 0.0718 0.178
Trichomonas vaginalis AGC family protein kinase 0.0142 0.0819 0.5294
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0432 0.2566
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0092 0.0437 0.3304
Echinococcus granulosus serine:threonine protein kinase 3 0.0242 0.1587 0.3933
Trichomonas vaginalis STE family protein kinase 0.0078 0.0328 0.1833
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0165 0.0996 0.0993
Loa Loa (eye worm) hypothetical protein 0.0114 0.0608 0.0604
Echinococcus multilocularis tyrosine protein kinase Fyn 0.009 0.0419 0.1257
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0065 0.0233 0.1405
Schistosoma mansoni tyrosine kinase 0.0244 0.1599 0.4982
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0056 0.0056
Loa Loa (eye worm) variant SH3 domain-containing protein 0.004 0.0039 0.0035
Schistosoma mansoni serine/threonine-protein kinase 0.0083 0.0367 0.1143
Echinococcus granulosus dual specificity 0.0129 0.0718 0.178
Echinococcus granulosus STE20 serine:threonine protein kinase 0.047 0.3338 0.8273
Entamoeba histolytica protein kinase, putative 0.0057 0.0168 0.1069
Echinococcus granulosus serine/threonine protein kinase 0.0083 0.0367 0.091
Echinococcus multilocularis epidermal growth factor receptor 0.0237 0.1552 0.4648
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0048 0.0096 0.0204
Schistosoma mansoni tyrosine kinase 0.0252 0.1666 0.5189
Schistosoma mansoni serine/threonine protein kinase 0.0234 0.1526 0.4753
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0154 0.0481
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0181 0.1117 0.1114
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0048 0.0096 0.0246
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0143 0.0828 0.6465
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.004 0.0039 0.0035
Echinococcus multilocularis c src tyrosine kinase 0.0062 0.0203 0.0609
Trichomonas vaginalis CMGC family protein kinase 0.0129 0.0718 0.4584
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0143 0.0828 0.6465
Brugia malayi Kinase associated domain 1 family protein 0.0059 0.0181 0.0181
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.01 0.0495 0.0491
Echinococcus multilocularis tyrosine protein kinase Abl 0.0147 0.0862 0.2583
Trichomonas vaginalis AGC family protein kinase 0.0165 0.1 0.6574
Echinococcus multilocularis serine:threonine protein kinase 3 0.0242 0.1587 0.4754
Schistosoma mansoni protein kinase 0.0204 0.1294 0.4032
Plasmodium falciparum calcium-dependent protein kinase 1 0.0092 0.0437 0.3142
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0159 0.0947 0.2837
Loa Loa (eye worm) hypothetical protein 0.0081 0.0353 0.0349
Brugia malayi Protein kinase domain containing protein 0.02 0.1265 0.1265
Giardia lamblia Kinase, CMGC MAPK 0.0076 0.0311 0.2069
Leishmania major protein kinase, putative 0.0142 0.0819 0.6388
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0126 0.0697 0.5409
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0293 0.5
Echinococcus granulosus epidermal growth factor receptor 0.0237 0.1552 0.3845
Plasmodium falciparum protein serine/threonine kinase-1 0.0143 0.0828 0.6465
Loa Loa (eye worm) raf kinase 0.004 0.0039 0.0035
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0143 0.0828 0.6465
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0129 0.0718 0.5638
Echinococcus granulosus dual specificity protein kinase clk2 0.0143 0.0828 0.2051
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.0616 0.0612
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0197 0.1243 0.124
Echinococcus multilocularis casein kinase I alpha 0.01 0.0495 0.1481
Trypanosoma brucei Casein kinase II 0.0091 0.0432 0.3096
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0092 0.0437 0.1083
Schistosoma mansoni protein kinase 0.0412 0.2892 0.9011
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0353 0.2009
Trypanosoma cruzi cdc2-related kinase 1 0.0197 0.1243 1
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0132 0.0741 0.2309
Echinococcus granulosus protein kinase shaggy 0.0165 0.0996 0.2469
Loa Loa (eye worm) TK protein kinase 0.0074 0.0295 0.0291
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0092 0.0437 0.3222
Loa Loa (eye worm) AGC/PKA protein kinase 0.0065 0.0233 0.0229
Brugia malayi Homeodomain interacting protein kinase protein 1 0.019 0.1192 0.1192
Echinococcus granulosus nervana 2 0.0053 0.0136 0.0337
Onchocerca volvulus 0.0073 0.0289 0.0895
Echinococcus multilocularis 0.02 0.1267 0.3796
Trypanosoma cruzi aurora B kinase, putative 0.0142 0.0819 0.6388
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0076 0.0318 0.2313
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0189 0.118 0.3534
Loa Loa (eye worm) hypothetical protein 0.0045 0.0078 0.0075
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0293 0.0914
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0076 0.0318 0.2313
Schistosoma mansoni tyrosine kinase 0.0237 0.1552 0.4834
Brugia malayi Protein kinase domain containing protein 0.0372 0.2584 0.2584
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0204 0.1294 0.3877
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0305 0.2072 0.5135
Brugia malayi RhoGAP domain containing protein 0.004 0.0039 0.0039
Echinococcus multilocularis neuroglian 0.0038 0.0022 0.0067
Loa Loa (eye worm) hypothetical protein 0.0037 0.0011 0.0007
Entamoeba histolytica protein kinase, putative 0.006 0.0193 0.1279
Plasmodium vivax serine/threonine-protein kinase Nek1, putative 0.0044 0.0067 0.0117
Onchocerca volvulus 0.0045 0.0079 0.0232
Entamoeba histolytica protein kinase domain containing protein 0.0165 0.0996 0.7946
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0374 0.26 0.7788
Echinococcus granulosus cyclin dependent kinase 5 0.0197 0.1243 0.3082
Trichomonas vaginalis CMGC family protein kinase 0.0129 0.0718 0.4584
Loa Loa (eye worm) hypothetical protein 0.004 0.0039 0.0035
Brugia malayi Temporarily assigned gene name protein 59 0.0124 0.0682 0.0682
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0143 0.0828 0.0824
Schistosoma mansoni protein kinase C 0.0041 0.0048 0.015
Trypanosoma brucei SNF1-related protein kinases, putative 0.0081 0.0353 0.2425
Brugia malayi intracellular kinase 0.0165 0.0996 0.0996
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0063 0.0216 0.0535
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0353 0.2009
Schistosoma mansoni rap gtpase-activating protein 0.0132 0.0741 0.2309
Loa Loa (eye worm) casein kinase 0.0173 0.106 0.1056
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0142 0.0819 0.6431
Entamoeba histolytica protein kinase, putative 0.0165 0.1 0.7982
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0353 0.2009
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0092 0.0437 0.3142
Loa Loa (eye worm) hypothetical protein 0.0069 0.026 0.0256
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0065 0.0233 0.1405
Echinococcus multilocularis tyrosine protein kinase Fyn 0.009 0.0419 0.1257
Echinococcus multilocularis Diacylglycerol kinase theta 0.004 0.0039 0.0117
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0105 0.0535 0.0531
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.0819 0.2551
Loa Loa (eye worm) hypothetical protein 0.0065 0.0233 0.0229
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0076 0.0311 0.0307
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0123 0.0673 0.1668
Plasmodium falciparum calcium-dependent protein kinase 5 0.0092 0.0437 0.3142
Entamoeba histolytica PH domain containing protein kinase, putative 0.0069 0.0258 0.1818
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0058 0.0176 0.0526
Echinococcus multilocularis casein kinase I delta 0.01 0.0495 0.1481
Echinococcus granulosus rho-associated protein kinase 1 0.0448 0.3171 0.786
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.019 0.119 0.2949
Brugia malayi Protein kinase domain containing protein 0.0143 0.0828 0.0828
Echinococcus granulosus tyrosine protein kinase Fyn 0.009 0.0419 0.104
Echinococcus multilocularis 0.0116 0.0622 0.1863
Brugia malayi Immunoglobulin I-set domain containing protein 0.0131 0.0735 0.0735
Onchocerca volvulus 0.0137 0.0784 0.2458
Loa Loa (eye worm) TK/ABL protein kinase 0.027 0.1802 0.1799
Entamoeba histolytica protein kinase, putative 0.006 0.0193 0.1279
Echinococcus multilocularis protein kinase c epsilon type 0.0151 0.0887 0.2659
Brugia malayi Protein kinase domain containing protein 0.0197 0.1243 0.1243
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0074 0.0295 0.0732
Brugia malayi Protein kinase domain containing protein 0.0105 0.0535 0.0535
Brugia malayi SH2 domain containing protein 0.0045 0.0079 0.0079
Entamoeba histolytica casein kinase 1, putative 0.01 0.0495 0.3782
Trypanosoma brucei protein kinase, putative 0.0076 0.0311 0.2069
Giardia lamblia Kinase, AGC PKA 0.0065 0.0233 0.1405
Echinococcus multilocularis tyrosine protein kinase shark 0.0045 0.0079 0.0237
Loa Loa (eye worm) hypothetical protein 0.0045 0.0079 0.0075
Brugia malayi Serine/threonine-protein kinase SULU 0.0209 0.1332 0.1332
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0079 0.0075
Brugia malayi Protein kinase domain containing protein 0.0426 0.3 0.3
Echinococcus granulosus insulin receptor 0.0244 0.1599 0.3964
Giardia lamblia Kinase, CDC7 0.0082 0.0357 0.246
Brugia malayi cell division control protein 2 homolog 0.0197 0.1243 0.1243
Trichomonas vaginalis CMGC family protein kinase 0.0129 0.0718 0.4584
Brugia malayi Doublecortin family protein 0.014 0.0805 0.0805
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0037 0.0017 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.0353 0.1098
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0109 0.057 0.1412
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0306 0.0954
Leishmania major protein kinase, putative 0.0092 0.0437 0.3142
Brugia malayi Protein kinase domain containing protein 0.0352 0.2433 0.2433
Schistosoma mansoni tyrosine kinase 0.009 0.0419 0.1307
Trichomonas vaginalis CMGC family protein kinase 0.0076 0.0311 0.1715
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.028 0.1878 0.1875
Brugia malayi Ras association domain family 1 isoform A 0.004 0.0039 0.0039
Echinococcus multilocularis PAK box P21 Rho binding 0.0057 0.0168 0.0502
Toxoplasma gondii aurora kinase 0.0142 0.0819 0.6473
Echinococcus granulosus ephrin type A receptor 4 A 0.0089 0.0414 0.1027
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0054 0.0148 0.0686
Echinococcus multilocularis expressed protein 0.0075 0.0306 0.0917
Trypanosoma cruzi casein kinase, putative 0.01 0.0495 0.3632
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0062 0.0203 0.0633
Brugia malayi hypothetical protein 0.0037 0.0018 0.0018
Echinococcus granulosus tyrosine protein kinase ABL1 0.027 0.1802 0.4467
Trypanosoma brucei cdc2-related kinase 1 0.0197 0.1243 1
Trichomonas vaginalis STE family protein kinase 0.0076 0.0318 0.1763
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0081 0.0353 0.2425
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0432 0.2566
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0237 0.1552 0.3845
Schistosoma mansoni serine/threonine protein kinase 0.0209 0.1332 0.4149
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0132 0.0741 0.5729
Trypanosoma cruzi casein kinase, putative 0.01 0.0495 0.3632
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0039 0.0027 0.0066
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0216 0.0672
Schistosoma mansoni vav2 0.0061 0.0201 0.0626
Brugia malayi hypothetical protein 0.0045 0.0079 0.0079
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0045 0.0079 0.0333
Onchocerca volvulus 0.0041 0.0048 0.0135
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0164 0.0985 0.2952
Giardia lamblia Aurora kinase 0.0142 0.0819 0.6388
Echinococcus multilocularis Rac GTPase activating protein 1 0.004 0.0039 0.0117
Echinococcus granulosus tyrosine protein kinase Lyn 0.0117 0.0625 0.155
Brugia malayi RhoGEF domain containing protein 0.004 0.0039 0.0039
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0437 0.2604
Echinococcus granulosus Vam6:Vps39 protein 0.0132 0.0741 0.1837
Trichomonas vaginalis CMGC family protein kinase 0.0129 0.0718 0.4584
Loa Loa (eye worm) AGC/AKT protein kinase 0.0165 0.1 0.0997
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0293 0.5
Echinococcus granulosus calcium dependent protein kinase 0.0065 0.0231 0.0573
Echinococcus granulosus aurora kinase A 0.0142 0.0819 0.2029
Echinococcus multilocularis dual specificity 0.0129 0.0718 0.2151
Brugia malayi casein kinase I 0.01 0.0495 0.0495
Echinococcus granulosus myotubularin protein 13 0.0043 0.0064 0.0159
Loa Loa (eye worm) hypothetical protein 0.0092 0.0437 0.0433
Loa Loa (eye worm) TK protein kinase 0.0152 0.0901 0.0897
Trypanosoma brucei casein kinase I, isoform 2 0.01 0.0495 0.3632
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0495 0.1541
Echinococcus granulosus casein kinase I alpha 0.01 0.0495 0.1226
Echinococcus granulosus c src tyrosine kinase 0.0062 0.0203 0.0504
Onchocerca volvulus 0.0422 0.2965 0.935
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0092 0.0437 0.3304
Echinococcus granulosus roundabout 2 0.0053 0.0136 0.0338
Loa Loa (eye worm) hypothetical protein 0.004 0.0039 0.0035
Loa Loa (eye worm) AGC/NDR protein kinase 0.0109 0.057 0.0566
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0078 0.0328 0.0981
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0372 0.2584 0.7741
Plasmodium vivax calcium-dependent protein kinase, putative 0.0092 0.0437 0.3222
Giardia lamblia Kinase, CAMK CAMKL 0.0081 0.0353 0.2425
Entamoeba histolytica serine/threonine protein kinase, putative 0.0044 0.0067 0.0236
Onchocerca volvulus 0.0045 0.0079 0.0232
Onchocerca volvulus 0.0045 0.0079 0.0232
Leishmania major protein kinase, putative 0.0076 0.0318 0.2127
Loa Loa (eye worm) hypothetical protein 0.0177 0.1092 0.1088
Brugia malayi Protein kinase domain containing protein 0.0086 0.0387 0.0387
Brugia malayi protein kinase C II. 0.0151 0.0887 0.0887
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.0887 0.2765
Trypanosoma brucei protein kinase, putative 0.0054 0.0148 0.0686
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0181 0.1119 0.3517
Onchocerca volvulus 0.0181 0.1117 0.3512
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0374 0.26 0.2597
Onchocerca volvulus 0.0082 0.0357 0.111
Schistosoma mansoni serine/threonine kinase 0.0086 0.0387 0.1206
Loa Loa (eye worm) hypothetical protein 0.004 0.0039 0.0035
Echinococcus granulosus tyrosine protein kinase Fyn 0.009 0.0419 0.104
Schistosoma mansoni serine/threonine protein kinase 0.02 0.1265 0.3943
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0054 0.0148 0.0906
Echinococcus multilocularis roundabout 2 0.0053 0.0136 0.0408
Giardia lamblia Kinase, CMGC GSK 0.0165 0.0996 0.7897
Echinococcus multilocularis Glutaredoxin protein 5 0.0053 0.0136 0.0407
Loa Loa (eye worm) TK/EPH protein kinase 0.0106 0.0544 0.054
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0091 0.0432 0.3177
Loa Loa (eye worm) AUR protein kinase 0.0142 0.0819 0.0815
Echinococcus granulosus protein kinase c epsilon type 0.0151 0.0887 0.2199
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0079 0.0075
Loa Loa (eye worm) camk/dcamkl protein kinase 0.014 0.0805 0.0802
Schistosoma mansoni protein kinase 0.02 0.1267 0.3947
Trypanosoma cruzi rac serine-threonine kinase, putative 0.008 0.0342 0.2332
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0041 0.0048 0.0145
Schistosoma mansoni serine/threonine protein kinase 0.0143 0.0828 0.2579
Entamoeba histolytica protein kinase, putative 0.0129 0.0718 0.5638
Echinococcus multilocularis mitogen activated protein kinase 0.0076 0.0311 0.0931
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0065 0.0233 0.0697
Echinococcus multilocularis 0.0106 0.0542 0.1623
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1338 1 1
Entamoeba histolytica protein kinase, putative 0.0165 0.0996 0.7946
Giardia lamblia Kinase, CMGC CLK 0.0143 0.0828 0.6465
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0076 0.0311 0.2256
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0164 0.0985 0.2442
Giardia lamblia Kinase, CMGC CK2 0.0091 0.0432 0.3096
Echinococcus multilocularis mitogen activated protein kinase 3 0.0076 0.0311 0.0931
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0036 0.0004 0.001
Schistosoma mansoni protein kinase C mu 0.004 0.0039 0.0121
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0076 0.0318 0.2127
Schistosoma mansoni protein kinase 0.0332 0.2278 0.7096
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0092 0.0437 0.1309
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0054 0.0148 0.0686
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.0353 0.1098
Schistosoma mansoni protein kinase 0.0412 0.2892 0.9011
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0432 0.2566
Loa Loa (eye worm) hypothetical protein 0.0132 0.0741 0.0738
Schistosoma mansoni serine/threonine kinase 0.0109 0.057 0.1775
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0065 0.0233 0.0697
Loa Loa (eye worm) hypothetical protein 0.0078 0.0331 0.0328
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.019 0.1192 0.1188
Leishmania major protein kinase A catalytic subunit isoform 2 0.0065 0.0233 0.1405
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0353 0.2009
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0053 0.0136 0.0337
Schistosoma mansoni serine/threonine protein kinase 0.0164 0.0985 0.307
Schistosoma mansoni diacylglycerol kinase theta 0.004 0.0039 0.0121
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0152 0.0901 0.0897
Brugia malayi MH2 domain containing protein 0.0115 0.0616 0.0616
Loa Loa (eye worm) hypothetical protein 0.004 0.0039 0.0035
Echinococcus multilocularis mitogen activated protein kinase 11 0.0148 0.0867 0.2596
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0432 0.2566
Brugia malayi Protein kinase domain containing protein 0.0045 0.0079 0.0079
Plasmodium falciparum protein kinase 5 0.0197 0.1243 1
Trichomonas vaginalis AGC family protein kinase 0.0126 0.0697 0.4437
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0056 0.0174
Brugia malayi SH2 domain containing protein 0.017 0.1038 0.1038
Giardia lamblia Kinase, STE STE20 0.0078 0.0328 0.2212
Loa Loa (eye worm) hypothetical protein 0.0143 0.0826 0.0822
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0353 0.2009
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0164 0.0989 0.0986
Echinococcus multilocularis tyrosine protein kinase Src64B 0.009 0.0419 0.1257
Giardia lamblia Kinase, CMGC GSK 0.0165 0.0996 0.7897
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0197 0.1243 0.3082
Echinococcus granulosus casein kinase I delta 0.01 0.0495 0.1226
Plasmodium falciparum serine/threonine protein kinase KIN 0.0081 0.0353 0.2425
Echinococcus granulosus casein kinase i 0.01 0.0495 0.1226
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0065 0.0233 0.1405
Echinococcus multilocularis aurora kinase A 0.0142 0.0819 0.2453
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0197 0.1243 0.124
Onchocerca volvulus 0.01 0.0495 0.1545
Schistosoma mansoni serine/threonine protein kinase 0.0448 0.3171 0.988
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0079 0.0075
Entamoeba histolytica protein kinase, putative 0.0075 0.0306 0.2218
Loa Loa (eye worm) hypothetical protein 0.0116 0.0622 0.0618
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.0353 0.1098
Brugia malayi Protein kinase domain containing protein 0.0153 0.0903 0.0903
Brugia malayi Protein kinase domain containing protein 0.0109 0.057 0.057
Trypanosoma cruzi casein kinase, putative 0.01 0.0495 0.3632
Onchocerca volvulus 0.0045 0.0079 0.0232
Entamoeba histolytica protein kinase, putative 0.0093 0.0446 0.3381
Schistosoma mansoni protein kinase 0.0078 0.0328 0.1021
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0042 0.0056 0.0052
Entamoeba histolytica protein kinase domain containing protein 0.0129 0.0718 0.5638
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0065 0.0233 0.1405
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.01 0.0495 0.0491
Echinococcus granulosus mitogen activated protein kinase 3 0.0076 0.0311 0.077
Toxoplasma gondii NEK kinase 0.0044 0.0067 0.0236
Entamoeba histolytica serine/threonine protein kinase, putative 0.0081 0.0353 0.2603
Schistosoma mansoni unc-13 (munc13) 0.0041 0.0048 0.015
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0045 0.0073 0.0284
Brugia malayi hypothetical protein 0.0054 0.0147 0.0147
Echinococcus multilocularis cyclin dependent kinase 1 0.0197 0.1243 0.3725
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0092 0.0437 0.1083
Loa Loa (eye worm) hypothetical protein 0.0113 0.0601 0.0598
Brugia malayi map kinase activated protein kinase protein 2 0.0374 0.26 0.26
Echinococcus multilocularis casein kinase I gamma 0.02 0.1265 0.3791
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0058 0.0176 0.0547
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0153 0.0903 0.09
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0188 0.1173 0.3515
Echinococcus multilocularis tyrosine protein kinase Fyn 0.009 0.0419 0.1257
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0018 0.0018
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0109 0.057 0.1412
Schistosoma mansoni serine/threonine protein kinase 0.0453 0.321 1
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0079 0.0075
Schistosoma mansoni serine/threonine protein kinase 0.0245 0.1613 0.5024
Schistosoma mansoni protein kinase 0.0091 0.0432 0.1344
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0828 0.5357
Echinococcus multilocularis myotubularin protein 13 0.0043 0.0064 0.0193
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0038 0.0023 0.0069
Trichomonas vaginalis STE family protein kinase 0.0057 0.0168 0.0707
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0197 0.1243 0.124
Loa Loa (eye worm) hypothetical protein 0.0051 0.0122 0.0118
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0109 0.057 0.1707
Echinococcus multilocularis dual specificity 0.0129 0.0718 0.2151
Echinococcus granulosus casein kinase I alpha 0.01 0.0495 0.1226
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0065 0.0233 0.1506
Echinococcus granulosus epidermal growth factor receptor 0.0371 0.2575 0.6381
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0065 0.0233 0.0577
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0357 0.1111
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0204 0.1298 0.1298
Schistosoma mansoni protein kinase 0.0142 0.0819 0.2551
Entamoeba histolytica PH domain containing protein kinase, putative 0.0083 0.0367 0.2723
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0245 0.1613 0.3997
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0232 0.1507 0.1504
Loa Loa (eye worm) TK protein kinase 0.0287 0.1934 0.1931
Schistosoma mansoni tyrosine kinase 0.0062 0.0203 0.0633
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.018 0.1115 0.1111
Brugia malayi Protein kinase domain containing protein 0.0287 0.1934 0.1934
Entamoeba histolytica protein kinase domain containing protein 0.0142 0.0819 0.6473
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0293 0.5
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0165 0.0996 0.2984
Echinococcus granulosus activin receptor type 0.0054 0.0148 0.0367
Trypanosoma brucei protein kinase, putative 0.0165 0.0996 0.7897
Plasmodium vivax serine/threonine-protein kinase NEK4, putative 0.0044 0.0067 0.0117
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0129 0.0718 0.5532
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0054 0.0148 0.0686
Brugia malayi protein unc-22 0.0042 0.0056 0.0056
Brugia malayi Protein kinase domain containing protein 0.0109 0.057 0.057
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0242 0.1587 0.1584
Giardia lamblia Kinase, CAMK CAMKL 0.0081 0.0353 0.2425
Loa Loa (eye worm) TK protein kinase 0.0056 0.0158 0.0155
Schistosoma mansoni protein kinase 0.0078 0.0328 0.1021
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.019 0.119 0.1186
Echinococcus multilocularis titin 0.0042 0.0056 0.0167
Echinococcus granulosus raf serine:threonine protein kinase 0.0068 0.0251 0.0621
Trypanosoma cruzi casein kinase, putative 0.01 0.0495 0.3632
Loa Loa (eye worm) hypothetical protein 0.0059 0.0181 0.0177
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0353 0.2009
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0293 0.0727
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0387 0.2253
Entamoeba histolytica protein kinase, putative 0.0063 0.0216 0.1468
Entamoeba histolytica protein kinase, putative 0.0162 0.0975 0.7771
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0353 0.2009
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0148 0.0867 0.6795
Plasmodium falciparum casein kinase 1 0.01 0.0495 0.3632
Echinococcus multilocularis dual specificity protein kinase clk2 0.0143 0.0828 0.248
Trichomonas vaginalis AGC family protein kinase 0.0165 0.1 0.6574
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0081 0.0353 0.2425
Schistosoma mansoni nephrin 0.0046 0.008 0.0249
Brugia malayi Tyrosine-protein kinase abl-1 0.0139 0.0795 0.0795
Leishmania major casein kinase, putative 0.01 0.0495 0.3632
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0353 0.2009
Echinococcus granulosus unc 13 munc13 0.0041 0.0048 0.012
Plasmodium vivax unspecified product 0.0091 0.0432 0.3177
Brugia malayi Furin-like cysteine rich region family protein 0.0371 0.2575 0.2575
Leishmania major protein kinase A catalytic subunit 0.0065 0.0233 0.1405
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0143 0.0828 0.6465
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0174 0.1063 0.106
Trypanosoma cruzi casein kinase II, putative 0.0091 0.0432 0.3096
Loa Loa (eye worm) hypothetical protein 0.0133 0.0754 0.075
Plasmodium falciparum calcium-dependent protein kinase 2 0.0092 0.0437 0.3142
Echinococcus multilocularis tyrosine protein kinase Fgr 0.009 0.0419 0.1257
Schistosoma mansoni protein kinase C mu 0.0204 0.1298 0.4043
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0535 0.3293
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.1273 0.127
Echinococcus multilocularis tyrosine protein kinase Blk 0.0074 0.0295 0.0884
Entamoeba histolytica protein kinase, putative 0.0078 0.0328 0.2396
Trichomonas vaginalis AGC family protein kinase 0.0165 0.1 0.6574
Echinococcus granulosus N chimaerin 0.0058 0.0176 0.0436
Echinococcus multilocularis tyrosine protein kinase Srms 0.0074 0.0295 0.0884
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0129 0.0718 0.5532
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0426 0.3 0.2997
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0076 0.0311 0.2069
Toxoplasma gondii NEK kinase 0.0044 0.0067 0.0236
Trichomonas vaginalis STE family protein kinase 0.0078 0.0328 0.1833
Brugia malayi casein kinase 1, delta 0.01 0.0495 0.0495
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0174 0.1063 0.1063
Schistosoma mansoni serine/threonine protein kinase 0.0189 0.118 0.3676
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0065 0.0233 0.1405
Trichomonas vaginalis CMGC family protein kinase 0.0076 0.0311 0.1715
Echinococcus multilocularis ephrin type A receptor 4 A 0.0089 0.0414 0.1241
Loa Loa (eye worm) hypothetical protein 0.0133 0.0754 0.075
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0432 0.2566
Schistosoma mansoni tyrosine kinase 0.0043 0.006 0.0187
Brugia malayi Temporarily assigned gene name protein 59 0.0132 0.0741 0.0741
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0165 0.0996 0.0993
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0065 0.0233 0.1405
Onchocerca volvulus 0.0045 0.0079 0.0232
Echinococcus granulosus tyrosine protein kinase Srms 0.0045 0.0079 0.0196
Trichomonas vaginalis CMGC family protein kinase 0.0129 0.0718 0.4584
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0129 0.0718 0.0718
Loa Loa (eye worm) hypothetical protein 0.0045 0.0078 0.0075
Echinococcus granulosus tyrosine protein kinase Src42A 0.009 0.0419 0.104
Echinococcus multilocularis casein kinase I alpha 0.01 0.0495 0.1481
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0048 0.0096 0.0096
Schistosoma mansoni serine/threonine protein kinase 0.0174 0.1063 0.3312
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0092 0.0437 0.0433
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0092 0.0437 0.1309
Entamoeba histolytica p21-activated kinase 0.0081 0.0353 0.2606
Schistosoma mansoni tyrosine kinase 0.021 0.134 0.4174
Plasmodium falciparum NIMA related kinase 1 0.0126 0.0697 0.5355
Entamoeba histolytica protein kinase, putative 0.0056 0.0158 0.0992
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0076 0.0311 0.2069
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0048 0.0096 0.0092
Loa Loa (eye worm) hypothetical protein 0.0132 0.0741 0.0738
Echinococcus granulosus RNA directed DNA polymerase 0.0038 0.0023 0.0057
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0076 0.0311 0.2069
Entamoeba histolytica protein kinase, putative 0.0092 0.0437 0.3304
Schistosoma mansoni protein kinase 0.0204 0.1294 0.4032
Giardia lamblia Kinase, CMGC CDK 0.0197 0.1243 1
Trichomonas vaginalis CMGC family protein kinase 0.0165 0.0996 0.6544
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0014
Echinococcus granulosus tyrosine protein kinase Fps85D 0.017 0.1038 0.2572
Echinococcus multilocularis serine threonine protein kinase 0.0149 0.0871 0.2611
Brugia malayi Protein kinase c protein 2 0.0106 0.0546 0.0546
Schistosoma mansoni hypothetical protein 0.0059 0.0181 0.0565
Brugia malayi protein-tyrosine kinase 0.0074 0.0295 0.0295
Echinococcus multilocularis protein kinase c eta type 0.004 0.0039 0.0117
Loa Loa (eye worm) hypothetical protein 0.0305 0.2072 0.2069
Loa Loa (eye worm) TK/EGFR protein kinase 0.0371 0.2575 0.2572
Entamoeba histolytica protein kinase domain containing protein 0.0091 0.0432 0.3259
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0165 0.0996 0.3103
Echinococcus multilocularis tyrosine protein kinase 0.0287 0.1934 0.5795
Echinococcus granulosus neuroglian 0.0038 0.0022 0.0055
Brugia malayi C1-like domain containing protein 0.0204 0.1298 0.1298
Brugia malayi Protein kinase domain containing protein 0.0045 0.0079 0.0079
Schistosoma mansoni tyrosine kinase 0.021 0.134 0.4174
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0293 0.0914
Giardia lamblia Kinase, NEK 0.0126 0.0697 0.5355
Schistosoma mansoni ste20-related kinase 0.0192 0.1206 0.3756
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0122 0.0383
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0143 0.0828 0.6465
Loa Loa (eye worm) hypothetical protein 0.0043 0.0064 0.006
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0078 0.0328 0.0812
Brugia malayi Pre-SET motif family protein 0.0201 0.1273 0.1273
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0233 0.0725
Schistosoma mansoni unc-13 (munc13) 0.0041 0.0048 0.015
Echinococcus multilocularis rac serine:threonine kinase 0.0083 0.0367 0.1099
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0067 0.021
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0148 0.0867 0.6795
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0353 0.2009
Loa Loa (eye worm) TK protein kinase 0.0131 0.0735 0.0731
Schistosoma mansoni tyrosine kinase 0.0062 0.0203 0.0633
Entamoeba histolytica protein kinase, putative 0.0063 0.0216 0.1468
Loa Loa (eye worm) hypothetical protein 0.026 0.1723 0.172
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0298 0.0928
Loa Loa (eye worm) AGC/PKA protein kinase 0.0065 0.0233 0.0229
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0086 0.0387 0.0383
Loa Loa (eye worm) AGC/PKN protein kinase 0.0234 0.1526 0.1522
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0153 0.0903 0.2238
Brugia malayi diacylglycerol kinase 0.004 0.0039 0.0039
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0079 0.0075
Loa Loa (eye worm) hypothetical protein 0.0041 0.0048 0.0044
Trichomonas vaginalis CK1 family protein kinase 0.01 0.0495 0.301
Onchocerca volvulus 0.0062 0.0203 0.0623
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0078 0.0328 0.0981
Trichomonas vaginalis AGC family protein kinase 0.0165 0.1 0.6574
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0076 0.0318 0.2127
Schistosoma mansoni protein kinase 0.018 0.1115 0.3473
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0437 0.1361
Onchocerca volvulus 0.0082 0.0357 0.111
Echinococcus granulosus tyrosine kinase 0.0074 0.0295 0.0732
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0142 0.0819 0.2453
Echinococcus granulosus tyrosine protein kinase Src42A 0.0046 0.0084 0.0207
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0076 0.0311 0.2069
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0432 0.2566
Brugia malayi hypothetical protein 0.0209 0.1332 0.1332
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0154 0.0383
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0081 0.0353 0.0349
Giardia lamblia Kinase, NEK 0.0126 0.0697 0.5355
Giardia lamblia Kinase, AGC PKA 0.008 0.0342 0.2332
Leishmania major casein kinase II, putative 0.0091 0.0432 0.3096
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0129 0.0718 0.5532
Leishmania major protein kinase, putative 0.0143 0.0828 0.6465
Schistosoma mansoni tyrosine kinase 0.0244 0.1599 0.4982
Giardia lamblia Kinase, STE STE20 0.0076 0.0318 0.2127
Trichomonas vaginalis AGC family protein kinase 0.0113 0.0595 0.3719
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.032 0.2186 0.2186
Schistosoma mansoni serine/threonine-protein kinase 0.0083 0.0367 0.1143
Loa Loa (eye worm) AUR protein kinase 0.0142 0.0819 0.0815
Schistosoma mansoni tyrosine kinase 0.0058 0.0173 0.054
Schistosoma mansoni diacylglycerol kinase theta 0.004 0.0039 0.0121
Plasmodium falciparum protein kinase, putative 0.0054 0.0148 0.0686
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0096 0.03
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0209 0.1332 0.1328
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0081 0.0353 0.2425
Schistosoma mansoni serine/threonine protein kinase 0.0143 0.0828 0.2579
Echinococcus multilocularis protein kinase shaggy 0.0165 0.0996 0.2984
Trichomonas vaginalis AGC family protein kinase 0.0109 0.057 0.354
Trichomonas vaginalis STE family protein kinase 0.0078 0.0328 0.1833
Echinococcus multilocularis activin receptor type 0.0054 0.0148 0.0444
Giardia lamblia Kinase, CK1 Casein kinase 0.01 0.0495 0.3632
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0092 0.0437 0.3304
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0058 0.0176 0.0547
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0065 0.0233 0.0577
Schistosoma mansoni hypothetical protein 0.0132 0.0741 0.2309
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0081 0.0353 0.2425
Trypanosoma brucei cdc2-related kinase 3 0.0197 0.1243 1
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.057 0.1775
Echinococcus multilocularis serine:threonine protein kinase N2 0.0125 0.0686 0.2057
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.005 0.0112 0.0108
Echinococcus multilocularis rho associated protein kinase 0.0448 0.3171 0.95
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0078 0.0328 0.0812
Plasmodium vivax protein kinase Crk2 0.0197 0.1243 1
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0245 0.1613 0.4831
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0014
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.0616 0.0612
Entamoeba histolytica protein kinase 2, putative 0.008 0.0342 0.2513
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.008 0.0342 0.0847
Trypanosoma cruzi cdc2-related kinase 3 0.0197 0.1243 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0068 0.0251 0.0751
Onchocerca volvulus 0.0177 0.1092 0.3432
Giardia lamblia Kinase, CMGC SRPK 0.0075 0.0306 0.203
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.057 0.1775
Echinococcus granulosus twitchin 0.0065 0.0228 0.0565
Echinococcus granulosus tyrosine protein kinase Fyn 0.009 0.0419 0.104
Echinococcus granulosus hypothetical protein 0.0116 0.0622 0.1541
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0065 0.0233 0.0697
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0353 0.2009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0154 0.0463
Trichomonas vaginalis AGC family protein kinase 0.0142 0.0819 0.5294
Echinococcus multilocularis tyrosine kinase 0.0045 0.0079 0.0237
Brugia malayi MAP kinase sur-1 0.0076 0.0311 0.0311
Echinococcus multilocularis serine:threonine protein kinase 0.0105 0.0535 0.1602
Trypanosoma cruzi p21-activated kinase 3, putative 0.0048 0.0096 0.0246
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0081 0.0353 0.1056
Brugia malayi Protein kinase domain 0.0078 0.0328 0.0328
Onchocerca volvulus 0.0132 0.0741 0.2324
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0075 0.0306 0.203
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0432 0.2566
Echinococcus granulosus titin 0.0042 0.0056 0.0139
Brugia malayi hypothetical protein 0.0132 0.0741 0.0741
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0218 0.1404 0.1401
Echinococcus granulosus tyrosine protein kinase HCK 0.0056 0.0158 0.0393
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0126 0.0697 0.5464
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0233 0.1164
Schistosoma mansoni hypothetical protein 0.0059 0.0181 0.0565
Trichomonas vaginalis AGC family protein kinase 0.0109 0.057 0.354
Brugia malayi Protein kinase domain containing protein 0.0075 0.0306 0.0306
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0165 0.0996 0.7897
Trichomonas vaginalis CK1 family protein kinase 0.01 0.0495 0.301
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0204 0.1294 0.3208
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0046 0.0084 0.025
Entamoeba histolytica cell division protein kinase 2, putative 0.0197 0.1243 1
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0143 0.0828 0.6465
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0078 0.0328 0.0981
Trypanosoma cruzi casein kinase, delta isoform, putative 0.01 0.0495 0.3632
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0053 0.0136 0.0407
Brugia malayi serine/threonine-protein kinase 6 0.0142 0.0819 0.0819
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.009 0.0419 0.104
Echinococcus granulosus nervana 2 0.0053 0.0136 0.0337
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0353 0.2009
Loa Loa (eye worm) TK/INSR protein kinase 0.0244 0.1599 0.1596
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0181 0.1119 0.1119
Loa Loa (eye worm) hypothetical protein 0.0105 0.0535 0.0531
Schistosoma mansoni tyrosine kinase 0.0174 0.1062 0.331
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0293 0.2111
Echinococcus multilocularis serine:threonine protein kinase N2 0.0234 0.1526 0.4571
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0174 0.1063 0.3185
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0357 0.2039
Schistosoma mansoni titin 0.0042 0.0056 0.0174
Onchocerca volvulus 0.0045 0.0076 0.0222
Echinococcus granulosus calcium activated potassium channel 0.0086 0.0387 0.0959
Brugia malayi Tyrosine-protein kinase abl-1 0.0147 0.0862 0.0862
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0209 0.1332 0.3989
Brugia malayi Protein kinase domain containing protein 0.0045 0.0079 0.0079
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0233 0.0725
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0081 0.0353 0.2425
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0188 0.1173 0.2908
Entamoeba histolytica cell division protein kinase 2, putative 0.0197 0.1243 1
Brugia malayi Protein kinase domain containing protein 0.0244 0.1599 0.1599
Brugia malayi Cam kinase protein 1 0.0092 0.0437 0.0437
Brugia malayi ephrin receptor 1 precursor 0.0057 0.0165 0.0165
Trichomonas vaginalis STE family protein kinase 0.0126 0.0697 0.4437
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0387 0.1206
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0143 0.0828 0.6548
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0561 0.4035 1
Echinococcus multilocularis mitogen activated protein kinase 14 0.0148 0.0867 0.2596
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0353 0.2009
Echinococcus multilocularis cyclin dependent kinase 5 0.0197 0.1243 0.3725
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0075 0.0306 0.203
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0111 0.0582 0.4375
Brugia malayi serine/threonine kinase 12 0.0142 0.0819 0.0819
Brugia malayi Fibronectin type III domain containing protein 0.0037 0.0018 0.0018
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0164 0.0985 0.2442
Plasmodium vivax serine/threonine kinase-1, putative 0.0143 0.0828 0.6506
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0014
Brugia malayi RhoGAP domain containing protein 0.0058 0.0176 0.0176
Entamoeba histolytica protein kinase, putative 0.0142 0.0819 0.6473
Echinococcus multilocularis casein kinase I delta 0.01 0.0495 0.1481
Leishmania major protein kinase, putative 0.0143 0.0828 0.6465
Onchocerca volvulus 0.0165 0.0996 0.3129
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0109 0.057 0.1707
Brugia malayi serine/threonine protein kinase 6 0.0142 0.0819 0.0819
Schistosoma mansoni serine/threonine protein kinase 0.0189 0.118 0.3676
Plasmodium falciparum calcium-dependent protein kinase 4 0.0092 0.0437 0.3142
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.019 0.1192 0.357
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0233 0.0725
Giardia lamblia Kinase, CMGC DYRK 0.0129 0.0718 0.5532
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0073 0.0289 0.1882
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0142 0.0819 0.6473
Entamoeba histolytica protein kinase , putative 0.0142 0.0819 0.6473
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0412 0.2892 0.7169
Echinococcus multilocularis casein kinase ii subunit alpha 0.0091 0.0432 0.1293
Echinococcus granulosus Protein kinase C brain isozyme 0.0189 0.118 0.2924
Trichomonas vaginalis CMGC family protein kinase 0.0197 0.1243 0.8287
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0387 0.1206
Schistosoma mansoni hypothetical protein 0.004 0.0039 0.0121
Echinococcus granulosus protein kinase c iota type 0.0229 0.1489 0.3691
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0181 0.1119 0.1115
Plasmodium vivax casein kinase 1, putative 0.01 0.0495 0.3706
Onchocerca volvulus 0.0042 0.0056 0.0159
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0132 0.0741 0.5729
Loa Loa (eye worm) CAMK protein kinase 0.0042 0.0056 0.0052
Entamoeba histolytica protein kinase, putative 0.0109 0.057 0.4407
Echinococcus granulosus mitogen activated protein kinase 0.0076 0.0311 0.077
Echinococcus granulosus serine:threonine kinase SAD 1 0.0081 0.0353 0.0874
Brugia malayi Fes/CIP4 homology domain containing protein 0.0089 0.0414 0.0414
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0165 0.0996 0.2469
Echinococcus multilocularis nervana 2 0.0053 0.0136 0.0407
Schistosoma mansoni serine/threonine protein kinase 0.0374 0.26 0.8099
Onchocerca volvulus 0.0448 0.3171 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0154 0.0151
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0353 0.2009
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0142 0.0819 0.6473
Echinococcus multilocularis calcium activated potassium channel 0.0086 0.0387 0.116
Echinococcus multilocularis hypothetical protein 0.0059 0.0181 0.0543
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0092 0.0437 0.0433
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0293 0.5
Brugia malayi Protein kinase domain containing protein 0.0045 0.0079 0.0079
Schistosoma mansoni serine/threonine protein kinase 0.0181 0.1119 0.3485
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0132 0.0741 0.222
Echinococcus granulosus protein kinase 0.02 0.1267 0.314
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0197 0.1243 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0074 0.0295 0.0732
Schistosoma mansoni serine/threonine protein kinase 0.019 0.1192 0.3713
Entamoeba histolytica protein kinase, putative 0.0045 0.0073 0.0284
Loa Loa (eye worm) hypothetical protein 0.0143 0.0826 0.0822
Echinococcus granulosus fibroblast growth factor receptor 4 0.0123 0.0673 0.1668
Schistosoma mansoni tyrosine kinase 0.0045 0.0079 0.0246
Schistosoma mansoni vam6/vps39 related 0.0132 0.0741 0.2309
Entamoeba histolytica protein kinase domain containing protein 0.0165 0.0996 0.7946
Echinococcus multilocularis calcium dependent protein kinase 0.0065 0.0231 0.0692
Echinococcus granulosus tyrosine protein kinase shark 0.0045 0.0079 0.0196
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0412 0.2892 0.8665
Brugia malayi Protein kinase domain containing protein 0.0165 0.1 0.1
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.008 0.0342 0.2332
Trichomonas vaginalis set domain proteins, putative 0.0229 0.1487 1
Echinococcus granulosus NDR protein kinase 0.0109 0.057 0.1412
Loa Loa (eye worm) hypothetical protein 0.0137 0.0784 0.078
Entamoeba histolytica protein kinase domain containing protein 0.0054 0.0148 0.0906
Echinococcus multilocularis serine:threonine protein kinase 38 0.0109 0.057 0.1707
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0387 0.1206
Echinococcus granulosus serine:threonine protein kinase N2 0.0234 0.1526 0.3781
Echinococcus multilocularis protein kinase c iota type 0.0229 0.1489 0.4462
Echinococcus multilocularis unc 13 (munc13) 0.0041 0.0048 0.0145
Echinococcus granulosus mitogen activated protein kinase 11 0.0148 0.0867 0.2148
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0311 0.0968
Loa Loa (eye worm) hypothetical protein 0.017 0.1038 0.1034
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.009 0.0419 0.104
Echinococcus granulosus titin 0.0042 0.0056 0.0139
Echinococcus granulosus cyclin dependent kinase 1 0.0197 0.1243 0.3082
Schistosoma mansoni protein kinase 0.0054 0.0148 0.0461
Entamoeba histolytica protein kinase, putative 0.0075 0.0306 0.2218
Trichomonas vaginalis AGC family protein kinase 0.0165 0.1 0.6574
Loa Loa (eye worm) thyroid receptor interactor 0.0089 0.0414 0.0411
Echinococcus multilocularis mitogen activated protein kinase 14 0.0148 0.0867 0.2596
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0174 0.1063 0.2635
Echinococcus granulosus cyclin dependent kinase 0.0197 0.1243 0.3082
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0132 0.0741 0.2309
Loa Loa (eye worm) hypothetical protein 0.0054 0.0147 0.0143
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0091 0.0432 0.0428
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0374 0.26 0.6443
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0078 0.0328 0.0812
Entamoeba histolytica PH domain containing protein kinase, putative 0.0069 0.0258 0.1818
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0075 0.0306 0.203
Echinococcus multilocularis serine:threonine protein kinase N2 0.0109 0.057 0.1707
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0148 0.0867 0.6795
Entamoeba histolytica protein kinase, putative 0.0165 0.1 0.7982
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0357 0.2039
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0251 0.1657 0.4964
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0132 0.0741 0.1837
Echinococcus granulosus casein kinase ii subunit alpha 0.0091 0.0432 0.1069
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0197 0.1243 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0147 0.0143
Trichomonas vaginalis CMGC family protein kinase 0.0197 0.1243 0.8287
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0353 0.2009
Echinococcus multilocularis casein kinase I alpha 0.01 0.0495 0.1481
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0076 0.0318 0.2127
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0123 0.0673 0.2016
Echinococcus multilocularis insulin receptor 0.0244 0.1599 0.4791
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0092 0.0437 0.0437
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0251 0.0781
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.008 0.0342 0.2422
Schistosoma mansoni protein kinase 0.0372 0.2584 0.805
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0083 0.0364 0.209
Plasmodium falciparum calcium-dependent protein kinase 3 0.0092 0.0437 0.3142
Entamoeba histolytica PH domain containing protein kinase, putative 0.0083 0.0367 0.2723
Brugia malayi Casein kinase II, alpha chain 0.0091 0.0432 0.0432
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.02 0.1267 0.1264
Loa Loa (eye worm) TK/ALK protein kinase 0.0255 0.1686 0.1683
Trypanosoma cruzi cdc2-related kinase 3 0.0197 0.1243 1
Brugia malayi Protein kinase domain containing protein 0.0255 0.1686 0.1686
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.0353 0.1098
Leishmania major protein kinase A catalytic subunit isoform 1 0.0065 0.0233 0.1405
Echinococcus granulosus casein kinase I delta 0.01 0.0495 0.1226
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0154 0.0463
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0092 0.0437 0.1309
Echinococcus multilocularis nervana 2 0.0053 0.0136 0.0407
Schistosoma mansoni serine/threonine protein kinase 0.0352 0.2433 0.7579
Schistosoma mansoni serine/threonine protein kinase 0.019 0.119 0.3707
Schistosoma mansoni serine/threonine protein kinase 0.0245 0.1613 0.5024
Brugia malayi P38 map kinase family protein 2 0.0148 0.0867 0.0867
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0092 0.0437 0.3222
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0251 0.1657 0.4107
Echinococcus granulosus casein kinase I alpha 0.01 0.0495 0.1226
Trichomonas vaginalis STE family protein kinase 0.0078 0.0328 0.1833
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0065 0.0233 0.1405
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0162 0.0975 0.0971
Echinococcus multilocularis mitogen activated protein kinase 11 0.0148 0.0867 0.2596
Echinococcus granulosus protein kinase c eta type 0.004 0.0039 0.0097
Brugia malayi Protein kinase domain containing protein 0.0082 0.0357 0.0357
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0154 0.0481
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0065 0.0233 0.1405
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0132 0.0741 0.5729
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.047 0.3338 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0154 0.0383
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0065 0.0233 0.1608
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0353 0.2009
Toxoplasma gondii NEK kinase 0.0044 0.0067 0.0236
Trichomonas vaginalis AGC family protein kinase 0.0109 0.057 0.354
Echinococcus granulosus dual specificity 0.0129 0.0718 0.178
Schistosoma mansoni protein kinase 0.0057 0.0168 0.0522
Echinococcus granulosus tyrosine kinase 0.0045 0.0079 0.0196
Giardia lamblia Kinase, AGC AKT 0.0108 0.0557 0.4159
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0081 0.0353 0.2513
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0148 0.0867 0.6795
Echinococcus multilocularis tyrosine protein kinase ABL1 0.027 0.1802 0.5399
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0058 0.0176 0.0172
Loa Loa (eye worm) RasGEF domain-containing protein 0.004 0.0039 0.0035
Trichomonas vaginalis CMGC family protein kinase 0.0076 0.0311 0.1715
Brugia malayi p70 ribosomal S6 kinase beta 0.0162 0.0975 0.0975
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0065 0.0233 0.0233
Schistosoma mansoni tyrosine kinase 0.0237 0.1552 0.4834
Echinococcus granulosus homeodomain interacting protein kinase 3 0.019 0.1192 0.2953
Echinococcus granulosus tyrosine protein kinase Src64B 0.009 0.0419 0.104
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0079 0.0075
Loa Loa (eye worm) hypothetical protein 0.0132 0.0741 0.0738
Echinococcus granulosus tyrosine protein kinase Btk29A 0.019 0.1187 0.2941
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.1243 0.3874
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0197 0.1243 1
Echinococcus granulosus mitogen activated protein kinase 14 0.0148 0.0867 0.2148
Loa Loa (eye worm) hypothetical protein 0.0174 0.1062 0.1059
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0065 0.0233 0.0697
Echinococcus granulosus Diacylglycerol kinase theta 0.004 0.0039 0.0097
Brugia malayi Hr1 repeat family protein 0.0234 0.1526 0.1526
Echinococcus granulosus tyrosine protein kinase 0.0287 0.1934 0.4794
Schistosoma mansoni atypical protein kinase C 0.0235 0.1534 0.478
Plasmodium falciparum glycogen synthase kinase 3 0.0165 0.0996 0.7897
Loa Loa (eye worm) protein kinase domain-containing protein 0.02 0.1265 0.1262
Toxoplasma gondii AGC kinase 0.0162 0.0975 0.7771
Echinococcus granulosus CDC7 cell division cycle 7 0.0082 0.0357 0.0884
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.1243 0.3874
Onchocerca volvulus 0.0229 0.1487 0.4679
Onchocerca volvulus 0.0133 0.0754 0.2364
Loa Loa (eye worm) AUR protein kinase 0.0142 0.0819 0.0815
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.008 0.0342 0.1023
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0073 0.0291 0.1899
Giardia lamblia Kinase, CMGC CDK 0.0197 0.1243 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0203 0.0199
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0142 0.0819 0.2029
Trichomonas vaginalis AGC family protein kinase 0.0142 0.0819 0.5294
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0108 0.0557 0.0557
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0181 0.1119 0.1115
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0066 0.0238 0.0234
Brugia malayi Protein kinase domain containing protein 0.0097 0.0471 0.0471
Echinococcus granulosus Rac GTPase activating protein 1 0.004 0.0039 0.0097
Brugia malayi Protein kinase domain containing protein 0.018 0.1115 0.1115
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0076 0.0311 0.2069
Loa Loa (eye worm) CDC7 protein kinase 0.0082 0.0357 0.0353
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0041 0.0048 0.012
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0372 0.2584 0.2581
Brugia malayi Variant SH3 domain containing protein 0.0058 0.0176 0.0176
Giardia lamblia Kinase, NEK 0.0126 0.0697 0.5355
Echinococcus granulosus casein kinase I gamma 0.02 0.1265 0.3136
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0074 0.0295 0.0884
Echinococcus granulosus serine:threonine protein kinase 0.0105 0.0535 0.1325
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0079 0.0075
Schistosoma mansoni tyrosine kinase 0.021 0.134 0.4174
Echinococcus multilocularis dual specificity 0.0129 0.0718 0.2151
Onchocerca volvulus 0.0045 0.0079 0.0232
Leishmania major protein kinase, putative 0.0054 0.0148 0.0686
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0123 0.0673 0.2016
Echinococcus multilocularis CDC7 cell division cycle 7 0.0082 0.0357 0.1069
Brugia malayi putative serine/threonine kinase SADA gamma 0.0081 0.0353 0.0353
Trypanosoma brucei aurora B kinase 0.0142 0.0819 0.6388
Trypanosoma cruzi Protein kinase B 0.0083 0.0367 0.2548
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.009 0.0419 0.1257
Entamoeba histolytica protein kinase, putative 0.0142 0.0819 0.6473
Loa Loa (eye worm) hypothetical protein 0.004 0.0039 0.0035
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0353 0.2009
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0353 0.2009
Onchocerca volvulus Serine\/threonine kinase homolog 0.0153 0.0903 0.2836
Echinococcus multilocularis tyrosine protein kinase Src42A 0.009 0.0419 0.1257
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0293 0.1921
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0293 0.0879
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.019 0.1187 0.3555
Echinococcus multilocularis myosin iiia 0.0076 0.0318 0.0951
Echinococcus granulosus serine:threonine protein kinase 0.0105 0.0535 0.1325
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.009 0.0419 0.1257
Schistosoma mansoni ephrin receptor 0.0089 0.0414 0.129
Entamoeba histolytica casein kinase, putative 0.01 0.0495 0.3782
Echinococcus multilocularis epidermal growth factor receptor 0.0371 0.2575 0.7713
Toxoplasma gondii AGC kinase 0.0065 0.0233 0.1608
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0073 0.0291 0.209
Echinococcus granulosus protein kinase C gamma type 0.0149 0.0871 0.216
Loa Loa (eye worm) TK/FER protein kinase 0.017 0.1038 0.1034
Brugia malayi Protein kinase domain containing protein 0.0181 0.1119 0.1119
Schistosoma mansoni tyrosine kinase 0.009 0.0419 0.1307
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0079 0.0075
Trypanosoma cruzi casein kinase, putative 0.01 0.0495 0.3632
Echinococcus multilocularis cyclin dependent kinase 1 0.0197 0.1243 0.3725
Trypanosoma cruzi cdc2-related kinase 1 0.0197 0.1243 1
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0092 0.0437 0.3222
Trichomonas vaginalis CMGC family protein kinase 0.0129 0.0718 0.4584
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.01 0.0495 0.0491
Toxoplasma gondii histone kinase SNF1, putative 0.0081 0.0353 0.2603
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0372 0.2584 0.6404
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.019 0.119 0.3565
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0151 0.0887 0.0884
Schistosoma mansoni protein kinase 0.01 0.0495 0.1541
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.017 0.1038 0.3108
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0048 0.0096 0.0092
Plasmodium falciparum serine/threonine protein kinase, putative 0.0142 0.0819 0.6388
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0153 0.0903 0.2706
Trichomonas vaginalis AGC family protein kinase 0.0165 0.1 0.6574
Loa Loa (eye worm) hypothetical protein 0.0038 0.0023 0.0019
Echinococcus granulosus serine:threonine protein kinase N2 0.0125 0.0686 0.1701
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0076 0.0311 0.2069
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0075 0.0306 0.2218
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0065 0.0233 0.0577
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0075 0.0306 0.0302
Trypanosoma brucei rac serine-threonine kinase, putative 0.0165 0.1 0.7933
Brugia malayi Protein kinase domain containing protein 0.0055 0.015 0.015
Schistosoma mansoni tyrosine kinase 0.0123 0.0673 0.2097
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0357 0.2039
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0063 0.0216 0.0534
Loa Loa (eye worm) hypothetical protein 0.0243 0.1593 0.159
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0092 0.0437 0.1083
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.009 0.0419 0.1257
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0063 0.0216 0.0646
Echinococcus multilocularis N chimaerin 0.0058 0.0176 0.0526
Brugia malayi protein kinase C3,putative 0.0147 0.0856 0.0856
Brugia malayi STE20-like kinase MST 0.0242 0.1587 0.1587
Trichomonas vaginalis AGC family protein kinase 0.0142 0.0819 0.5294
Brugia malayi serine/threonine-protein kinase PAK 7 0.0218 0.1404 0.1404
Plasmodium falciparum casein kinase 2, alpha subunit 0.0091 0.0432 0.3096
Brugia malayi Protein kinase domain containing protein 0.0181 0.1122 0.1122
Entamoeba histolytica casein kinase, putative 0.0091 0.0432 0.3259
Onchocerca volvulus Tyrosine kinase homolog 0.0202 0.1283 0.4035
Plasmodium vivax serine/threonine protein kinase, putative 0.0075 0.0306 0.2123
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0036 0.0004 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.024 0.1573 0.4902
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0083 0.0367 0.2548
Echinococcus multilocularis casein kinase i 0.01 0.0495 0.1481
Echinococcus granulosus serine threonine protein kinase nrc 0.008 0.0342 0.0847
Loa Loa (eye worm) hypothetical protein 0.0443 0.3132 0.313
Plasmodium vivax tyrosine kinase-like protein, putative 0.0073 0.0291 0.1994
Echinococcus multilocularis RNA directed DNA polymerase 0.0038 0.0023 0.0069
Brugia malayi diacylglycerol kinase 0.004 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0037 0.0017 0.0013
Echinococcus multilocularis serine:threonine protein kinase 0.0105 0.0535 0.1602
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0096 0.03
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0154 0.0481
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0352 0.2433 0.243
Onchocerca volvulus 0.0167 0.101 0.3172
Schistosoma mansoni tyrosine kinase 0.0371 0.2575 0.8021
Plasmodium vivax glycogen synthase kinase 3, putative 0.0165 0.0996 0.7921

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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