Detailed information for compound 1399287

Basic information

Technical information
  • TDR Targets ID: 1399287
  • Name: N-[3-cyano-1-(2-methylphenyl)pyrrolo[5,4-b]qu inoxalin-2-yl]propanamide
  • MW: 355.393 | Formula: C21H17N5O
  • H donors: 1 H acceptors: 4 LogP: 3.98 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)Nc1c(C#N)c2c(n1c1ccccc1C)nc1c(n2)cccc1
  • InChi: 1S/C21H17N5O/c1-3-18(27)25-20-14(12-22)19-21(24-16-10-6-5-9-15(16)23-19)26(20)17-11-7-4-8-13(17)2/h4-11H,3H2,1-2H3,(H,25,27)
  • InChiKey: PYUCRCFUMZPGBF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-cyano-1-(2-methylphenyl)-2-pyrrolo[5,4-b]quinoxalinyl]propanamide
  • N-[3-cyano-1-(2-methylphenyl)pyrrolo[5,4-b]quinoxalin-2-yl]propionamide
  • Oprea1_808396
  • MLS000068757
  • SMR000039884
  • STOCK1S-79400
  • ZINC02283981

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Homo sapiens caspase 7, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens caspase 1, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens formyl peptide receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni caspase-3 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni caspase-7 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis caspase Get druggable targets OG5_130238 All targets in OG5_130238
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus caspase Get druggable targets OG5_130238 All targets in OG5_130238
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum ko:K02187 caspase 3, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K04397 caspase 7, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus caspase 8 caspase 1, apoptosis-related cysteine peptidase 383 aa 312 aa 26.6 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Brugia malayi Cell death protein 3 precursor caspase 7, apoptosis-related cysteine peptidase 303 aa 256 aa 37.1 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tyrosine kinase 0.1137 0.0941 0.2425
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0263 0.0025 0.0189
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0404 0.0173 0.0171
Schistosoma mansoni serine/threonine protein kinase 0.0371 0.0138 0.035
Echinococcus granulosus protein kinase c iota type 0.086 0.065 0.0648
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.033 0.0094 0.0092
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.3253 0.316 0.3159
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.1485 0.1306 0.1304
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0306 0.0069 0.0065
Schistosoma mansoni serine/threonine protein kinase 0.0263 0.0025 0.0058
Echinococcus granulosus serine:threonine protein kinase 0.0371 0.0137 0.0135
Plasmodium falciparum cGMP-dependent protein kinase 0.0301 0.0064 0.062
Loa Loa (eye worm) thyroid receptor interactor 0.0911 0.0704 0.0702
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.1485 0.1306 0.1304
Loa Loa (eye worm) CMGC/CLK protein kinase 0.1133 0.0937 0.0935
Trichomonas vaginalis AGC family protein kinase 0.0695 0.0478 0.4449
Echinococcus granulosus tyrosine protein kinase pr2 0.0263 0.0025 0.0023
Schistosoma mansoni protein kinase 0.0451 0.0222 0.0567
Onchocerca volvulus 0.0435 0.0205 0.0259
Echinococcus multilocularis tyrosine protein kinase 0.0263 0.0025 0.0023
Entamoeba histolytica protein kinase, putative 0.0244 0.0004 0.0016
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0965 0.0761 0.0759
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0025 0.0189
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0263 0.0025 0.0189
Trichomonas vaginalis CK1 family protein kinase 0.0654 0.0435 0.4048
Loa Loa (eye worm) hypothetical protein 0.0931 0.0725 0.0723
Brugia malayi Protein kinase domain containing protein 0.0263 0.0025 0.0023
Echinococcus multilocularis serine:threonine protein kinase N2 0.0601 0.0379 0.0377
Trypanosoma brucei rac serine-threonine kinase, putative 0.0785 0.0572 0.0568
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0306 0.0069 0.0065
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.04 0.0168 0.0429
Plasmodium falciparum casein kinase 2, alpha subunit 0.0263 0.0024 0.0221
Brugia malayi Protein kinase domain containing protein 0.0263 0.0025 0.0023
Echinococcus granulosus cyclin dependent kinase 1 0.0476 0.0248 0.0246
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0377 0.0144 0.0142
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.1383 0.1199 0.1196
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0836 0.0626 0.0624
Onchocerca volvulus 0.0498 0.0271 0.0354
Entamoeba histolytica protein kinase, putative 0.0263 0.0025 0.0189
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0263 0.0025 0.0189
Schistosoma mansoni hypothetical protein 0.0747 0.0531 0.1367
Brugia malayi Hr1 repeat family protein 0.191 0.1752 0.175
Trichomonas vaginalis STE family protein kinase 0.1264 0.1074 1
Schistosoma mansoni serine/threonine protein kinase 0.0378 0.0145 0.0368
Brugia malayi Tyrosine-protein kinase abl-1 0.1293 0.1105 0.1103
Schistosoma mansoni serine/threonine protein kinase 0.1028 0.0826 0.2128
Loa Loa (eye worm) TK/ALK protein kinase 0.4998 0.499 0.4989
Trichomonas vaginalis STE family protein kinase 0.0404 0.0173 0.1607
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0609 0.0387 0.3809
Loa Loa (eye worm) hypothetical protein 0.0515 0.0288 0.0286
Echinococcus granulosus roundabout 2 0.033 0.0094 0.0092
Schistosoma mansoni nck2/grb4 0.0417 0.0185 0.0473
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0814 0.0602 0.0598
Loa Loa (eye worm) AGC/PKA protein kinase 0.0814 0.0602 0.06
Entamoeba histolytica tyrosine kinase, putative 0.0263 0.0025 0.0189
Loa Loa (eye worm) hypothetical protein 0.033 0.0094 0.0092
Entamoeba histolytica tyrosin kinase, putative 0.0263 0.0025 0.0189
Onchocerca volvulus 0.0498 0.0271 0.0354
Echinococcus multilocularis tyrosine protein kinase Src64B 0.1137 0.0941 0.0939
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0814 0.0602 0.06
Loa Loa (eye worm) hypothetical protein 0.1196 0.1002 0.1
Giardia lamblia Kinase, CAMK CAMKL 0.0422 0.0191 0.1748
Echinococcus granulosus tyrosine protein kinase Src42A 0.1137 0.0941 0.0939
Echinococcus granulosus tyrosine protein kinase Blk 0.0955 0.075 0.0748
Schistosoma mansoni protein kinase 0.0993 0.079 0.2035
Loa Loa (eye worm) hypothetical protein 0.0752 0.0537 0.0535
Echinococcus multilocularis hemicentin 1 0.0295 0.0058 0.0055
Brugia malayi Immunoglobulin I-set domain containing protein 0.0295 0.0058 0.0055
Onchocerca volvulus 0.0498 0.0271 0.0354
Loa Loa (eye worm) hypothetical protein 0.0263 0.0025 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0378 0.0145 0.1347
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0988 0.0785 0.0783
Entamoeba histolytica hypothetical protein 0.0424 0.0193 0.1596
Loa Loa (eye worm) TK protein kinase 0.0721 0.0504 0.0502
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.233 0.2192 0.219
Schistosoma mansoni rap gtpase-activating protein 0.0747 0.0531 0.1367
Onchocerca volvulus 0.068 0.0461 0.0628
Brugia malayi cyclin-dependent kinase 9 0.044 0.021 0.0208
Trichomonas vaginalis CMGC family protein kinase 0.0306 0.0069 0.0646
Trichomonas vaginalis CAMK family protein kinase 0.0347 0.0112 0.1045
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0263 0.0025 0.0189
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0417 0.0185 0.0183
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.1206 0.1013 0.101
Loa Loa (eye worm) hypothetical protein 0.0814 0.0602 0.06
Schistosoma mansoni serine/threonine protein kinase 0.0814 0.0602 0.155
Echinococcus granulosus cyclin dependent kinase 5 0.0476 0.0248 0.0246
Onchocerca volvulus 0.0498 0.0271 0.0354
Toxoplasma gondii AGC kinase 0.0739 0.0524 0.5162
Brugia malayi Protein kinase domain containing protein 0.5 0.4992 0.4991
Schistosoma mansoni serine/threonine protein kinase 0.0301 0.0064 0.016
Loa Loa (eye worm) CAMK/PKD protein kinase 0.1131 0.0934 0.0933
Brugia malayi Protein kinase domain containing protein 0.0601 0.0379 0.0377
Trichomonas vaginalis AGC family protein kinase 0.0646 0.0426 0.3963
Entamoeba histolytica tyrosine kinase, putative 0.0263 0.0025 0.0189
Plasmodium falciparum serine/threonine protein kinase 0.0244 0.0004 0.0024
Plasmodium falciparum tyrosine kinase-like protein 0.0263 0.0025 0.0229
Trypanosoma cruzi casein kinase, putative 0.0654 0.0435 0.0431
Echinococcus granulosus dual specificity 0.1383 0.1199 0.1197
Trichomonas vaginalis CAMK family protein kinase 0.0378 0.0145 0.1347
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.1487 0.1308 0.1306
Trypanosoma brucei cdc2-related kinase 3 0.0476 0.0248 0.0244
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0418 0.0187 0.0185
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.1137 0.0941 0.0939
Schistosoma mansoni protein kinase 0.2591 0.2466 0.6362
Trichomonas vaginalis CAMK family protein kinase 0.0378 0.0145 0.1347
Echinococcus multilocularis epidermal growth factor receptor 0.1121 0.0924 0.0922
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0459 0.023 0.0228
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0591 0.0368 0.0366
Trichomonas vaginalis CMGC family protein kinase 0.0263 0.0024 0.0223
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0934 0.0728 0.0726
Entamoeba histolytica hypothetical protein 0.0263 0.0025 0.0189
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0263 0.0025 0.0023
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.033 0.0094 0.0238
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Schistosoma mansoni protein kinase 0.0263 0.0025 0.0058
Loa Loa (eye worm) TK/FER protein kinase 0.0498 0.0271 0.0269
Echinococcus granulosus neuroglian 0.033 0.0094 0.0092
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0626 0.0405 0.0403
Brugia malayi Protein kinase domain containing protein 0.0263 0.0025 0.0023
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0695 0.0478 0.0476
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0263 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0752 0.0537 0.0535
Brugia malayi Immunoglobulin I-set domain containing protein 0.0295 0.0058 0.0055
Echinococcus granulosus lachesin 0.0295 0.0058 0.0055
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0452 0.0223 0.0221
Brugia malayi Protein kinase domain containing protein 0.0601 0.0379 0.0377
Loa Loa (eye worm) hypothetical protein 0.0989 0.0786 0.0784
Entamoeba histolytica tyrosine kinase, putative 0.0263 0.0025 0.0189
Brugia malayi Protein kinase domain containing protein 0.0452 0.0223 0.0221
Entamoeba histolytica protein kinase , putative 0.0695 0.0478 0.3973
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.1154 0.0959 0.0957
Loa Loa (eye worm) hypothetical protein 0.0281 0.0043 0.0041
Loa Loa (eye worm) TK/FER protein kinase 0.0498 0.0271 0.0269
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0836 0.0625 0.0623
Brugia malayi Protein kinase domain containing protein 0.6895 0.6979 0.6979
Loa Loa (eye worm) hypothetical protein 0.064 0.042 0.0418
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0263 0.0025 0.0023
Trypanosoma cruzi polo-like protein kinase, putative 0.0347 0.0112 0.0108
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0813 0.0601 0.0599
Loa Loa (eye worm) hypothetical protein 0.0263 0.0025 0.0023
Echinococcus granulosus casein kinase I delta 0.0654 0.0435 0.0433
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0467 0.0238 0.0234
Trypanosoma brucei protein kinase, putative 0.1206 0.1013 0.101
Schistosoma mansoni hypothetical protein 0.0345 0.011 0.0279
Schistosoma mansoni tyrosine kinase 0.0263 0.0025 0.0058
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0378 0.0145 0.0143
Brugia malayi ephrin receptor 1 precursor 0.0297 0.006 0.0058
Entamoeba histolytica hypothetical protein 0.1383 0.1199 1
Loa Loa (eye worm) protein kinase domain-containing protein 0.0263 0.0025 0.0023
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0459 0.023 0.0228
Schistosoma mansoni tyrosine kinase 0.0558 0.0334 0.0856
Schistosoma mansoni protein kinase 0.0451 0.0222 0.0567
Schistosoma mansoni serine/threonine protein kinase 0.3253 0.316 0.8156
Schistosoma mansoni tyrosine kinase 0.0263 0.0025 0.0058
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0378 0.0145 0.0143
Trichomonas vaginalis CMGC family protein kinase 0.0263 0.0024 0.0223
Entamoeba histolytica PH domain containing protein kinase, putative 0.0372 0.0138 0.1139
Brugia malayi Doublecortin family protein 0.0319 0.0083 0.0081
Brugia malayi Protein kinase domain containing protein 0.0806 0.0594 0.0592
Loa Loa (eye worm) TK/FER protein kinase 0.0263 0.0025 0.0023
Brugia malayi C-terminal src kinase protein 1 0.0263 0.0025 0.0023
Echinococcus granulosus casein kinase I alpha 0.0654 0.0435 0.0433
Schistosoma mansoni serine/threonine protein kinase 0.0814 0.0602 0.155
Trichomonas vaginalis CMGC family protein kinase 0.0244 0.0005 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.1154 0.0959 0.2471
Plasmodium vivax tyrosine kinase-like protein, putative 0.0263 0.0025 0.0229
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0263 0.0025 0.0058
Echinococcus granulosus tyrosine protein kinase Fyn 0.1137 0.0941 0.0939
Loa Loa (eye worm) hypothetical protein 0.0345 0.011 0.0108
Leishmania major protein kinase, putative 0.0609 0.0387 0.0383
Loa Loa (eye worm) hypothetical protein 0.0414 0.0183 0.018
Entamoeba histolytica serine/threonine kinase, putative 0.0263 0.0025 0.0189
Echinococcus multilocularis protein kinase 0.0263 0.0025 0.0023
Echinococcus granulosus defective proboscis extension response 0.0679 0.046 0.0458
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0814 0.0602 0.5936
Entamoeba histolytica protein kinase, putative 0.0426 0.0196 0.1616
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0263 0.0025 0.0023
Brugia malayi ribosomal protein S6 kinase alpha 3 0.1035 0.0833 0.0831
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0263 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0931 0.0725 0.0723
Toxoplasma gondii protein kinase domain-containing protein 0.0263 0.0025 0.0229
Brugia malayi Protein kinase domain containing protein 0.3978 0.392 0.3919
Echinococcus granulosus roundabout 2 0.033 0.0094 0.0092
Echinococcus multilocularis cyclin dependent kinase 9 0.0484 0.0256 0.0254
Brugia malayi Sex muscle abnormal protein 5 0.0417 0.0185 0.0183
Echinococcus granulosus calcium activated potassium channel 0.0371 0.0138 0.0135
Loa Loa (eye worm) serine/threonine protein kinase 0.0263 0.0025 0.0023
Entamoeba histolytica protein kinase, putative 0.0263 0.0025 0.0189
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0814 0.0602 0.06
Onchocerca volvulus Tyrosine kinase homolog 0.3136 0.3038 0.4332
Echinococcus granulosus dual specificity 0.0306 0.0069 0.0067
Schistosoma mansoni protein kinase C mu 0.1131 0.0934 0.2408
Schistosoma mansoni kinase 0.042 0.0188 0.0481
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0747 0.0531 0.0529
Schistosoma mansoni vam6/vps39 related 0.0747 0.0531 0.1367
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0609 0.0387 0.3809
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0263 0.0025 0.0023
Giardia lamblia Kinase, STE STE20 0.1264 0.1074 1
Echinococcus granulosus slit 2 protein 0.0277 0.0039 0.0037
Onchocerca volvulus 0.0777 0.0564 0.0775
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0609 0.0387 0.0385
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0554 0.0329 0.0327
Loa Loa (eye worm) AGC/PKN protein kinase 0.191 0.1752 0.175
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0591 0.0368 0.0366
Schistosoma mansoni protein kinase 0.0451 0.0222 0.0567
Brugia malayi SH2 domain containing protein 0.0498 0.0271 0.0269
Plasmodium falciparum serine/threonine protein kinase KIN 0.0378 0.0145 0.1414
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.2677 0.2556 0.2555
Entamoeba histolytica tyrosine kinase, putative 0.0263 0.0025 0.0189
Onchocerca volvulus 0.0498 0.0271 0.0354
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Leishmania major casein kinase II, putative 0.0263 0.0024 0.002
Echinococcus multilocularis titin 0.0418 0.0187 0.0185
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0263 0.0025 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Brugia malayi Immunoglobulin I-set domain containing protein 0.033 0.0094 0.0092
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0695 0.0478 0.4707
Trichomonas vaginalis AGC family protein kinase 0.0785 0.0572 0.5328
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0814 0.0602 0.06
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0476 0.0248 0.2434
Toxoplasma gondii protein kinase 0.0263 0.0025 0.0229
Entamoeba histolytica protein kinase domain containing protein 0.0695 0.0478 0.3973
Brugia malayi Protein kinase domain containing protein 0.0263 0.0025 0.0023
Loa Loa (eye worm) AGC/NDR protein kinase 0.0601 0.0379 0.0377
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0806 0.0594 0.0592
Echinococcus multilocularis serine:threonine protein kinase 3 0.0437 0.0207 0.0205
Echinococcus granulosus cyclin dependent kinase 0.0476 0.0248 0.0246
Giardia lamblia Kinase, PLK 0.0347 0.0112 0.1012
Echinococcus multilocularis dual specificity 0.0306 0.0069 0.0067
Brugia malayi Tyrosine-protein kinase abl-1 0.1481 0.1301 0.1299
Echinococcus granulosus protein kinase 0.0263 0.0025 0.0023
Brugia malayi putative serine/threonine kinase SADA gamma 0.0378 0.0145 0.0143
Brugia malayi hypothetical protein 0.0263 0.0025 0.0023
Entamoeba histolytica protein kinase, putative 0.0601 0.0379 0.3149
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0836 0.0626 0.0624
Loa Loa (eye worm) hypothetical protein 0.0714 0.0497 0.0495
Brugia malayi Immunoglobulin I-set domain containing protein 0.0295 0.0058 0.0055
Brugia malayi Protein kinase domain containing protein 0.233 0.2192 0.219
Schistosoma mansoni serine/threonine protein kinase 0.0389 0.0156 0.0398
Echinococcus multilocularis hemicentin 1 0.0295 0.0058 0.0055
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0912 0.0705 0.0703
Brugia malayi protein-tyrosine kinase 0.0955 0.075 0.0748
Trypanosoma cruzi casein kinase, putative 0.0654 0.0435 0.0431
Trichomonas vaginalis conserved hypothetical protein 0.0263 0.0025 0.0231
Schistosoma mansoni protein kinase 0.0404 0.0173 0.044
Schistosoma mansoni tyrosine kinase 0.0263 0.0025 0.0058
Leishmania major protein kinase, putative 0.0451 0.0222 0.0218
Schistosoma mansoni serine/threonine protein kinase 0.0418 0.0187 0.0478
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.1133 0.0937 0.0933
Trichomonas vaginalis STE family protein kinase 0.038 0.0147 0.1371
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0702 0.0485 0.0483
Echinococcus granulosus epidermal growth factor receptor 0.0966 0.0761 0.0759
Brugia malayi Protein kinase domain containing protein 0.0263 0.0025 0.0023
Brugia malayi Protein kinase domain containing protein 0.0498 0.0271 0.0269
Echinococcus multilocularis protein kinase c epsilon type 0.0769 0.0555 0.0553
Loa Loa (eye worm) TK/FER protein kinase 0.0263 0.0025 0.0023
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0554 0.0329 0.0327
Entamoeba histolytica tyrosine kinase, putative 0.0263 0.0025 0.0189
Schistosoma mansoni protein kinase 0.0988 0.0785 0.2021
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0263 0.0025 0.0189
Trichomonas vaginalis CMGC family protein kinase 0.0263 0.0024 0.0223
Schistosoma mansoni serine/threonine protein kinase 0.0383 0.015 0.0383
Schistosoma mansoni serine/threonine protein kinase 0.0554 0.0329 0.0845
Brugia malayi Immunoglobulin I-set domain containing protein 0.0714 0.0497 0.0495
Trichomonas vaginalis CMGC family protein kinase 0.0306 0.0069 0.0646
Schistosoma mansoni atypical protein kinase C 0.0866 0.0657 0.1692
Trichomonas vaginalis AGC family protein kinase 0.0785 0.0572 0.5328
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0263 0.0025 0.0023
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0263 0.0025 0.0023
Brugia malayi Protein kinase domain containing protein 0.0263 0.0025 0.0023
Schistosoma mansoni vesicular amine transporter 0.0679 0.046 0.1183
Schistosoma mansoni serine/threonine protein kinase 0.0476 0.0248 0.0635
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0295 0.0058 0.0055
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0244 0.0005 0.0001
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus multilocularis mitogen activated protein kinase 0.0244 0.0005 0.0003
Leishmania major protein kinase A catalytic subunit isoform 1 0.0814 0.0602 0.0598
Echinococcus multilocularis tyrosine protein kinase csk 0.0263 0.0025 0.0023
Brugia malayi Protein kinase domain containing protein 0.0263 0.0025 0.0023
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0654 0.0435 0.0433
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0263 0.0025 0.0189
Onchocerca volvulus 0.0467 0.0238 0.0306
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0025 0.0189
Loa Loa (eye worm) TK/FER protein kinase 0.0498 0.0271 0.0269
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0263 0.0025 0.0058
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0814 0.0602 0.0598
Giardia lamblia Kinase, CMGC DYRK 0.0306 0.0069 0.0611
Echinococcus multilocularis receptor type guanylyl cyclase 0.0263 0.0025 0.0023
Giardia lamblia Kinase, CMGC GSK 0.1206 0.1013 0.9434
Schistosoma mansoni serine/threonine protein kinase 0.0378 0.0145 0.0368
Entamoeba histolytica tyrosin kinase, putative 0.0263 0.0025 0.0189
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1137 0.0941 0.0939
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0025 0.0189
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0025 0.0189
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0554 0.0329 0.0327
Echinococcus granulosus hypothetical protein 0.0946 0.074 0.0738
Trichomonas vaginalis AGC family protein kinase 0.0814 0.0602 0.5607
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Loa Loa (eye worm) hypothetical protein 0.0417 0.0185 0.0183
Echinococcus multilocularis cyclin dependent kinase 9 0.044 0.021 0.0208
Entamoeba histolytica hypothetical protein 0.0266 0.0028 0.0216
Entamoeba histolytica protein kinase domain containing protein 0.044 0.021 0.1736
Echinococcus granulosus raf serine:threonine protein kinase 0.0429 0.0199 0.0197
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0266 0.0028 0.0216
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus granulosus retinal guanylyl cyclase 2 0.0263 0.0025 0.0023
Loa Loa (eye worm) TK protein kinase 0.0602 0.038 0.0378
Brugia malayi Raf kinase 0.0263 0.0025 0.0023
Schistosoma mansoni protein kinase 0.0263 0.0025 0.0058
Echinococcus multilocularis casein kinase I gamma 0.0389 0.0156 0.0154
Trichomonas vaginalis AGC family protein kinase 0.0785 0.0572 0.5328
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Schistosoma mansoni nephrin 0.0909 0.0702 0.1807
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0244 0.0004 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0263 0.0025 0.0023
Echinococcus granulosus cyclin dependent kinase 9 0.0484 0.0256 0.0254
Trichomonas vaginalis CAMK family protein kinase 0.0609 0.0387 0.3603
Brugia malayi Protein kinase domain containing protein 0.0263 0.0025 0.0023
Trichomonas vaginalis AGC family protein kinase 0.0695 0.0478 0.4449
Schistosoma mansoni tyrosine kinase 0.0263 0.0025 0.0058
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0591 0.0368 0.0366
Brugia malayi Tyrosine-protein kinase PR2 0.0263 0.0025 0.0023
Schistosoma mansoni tyrosine kinase 0.1533 0.1356 0.3497
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.2463 0.2331 0.233
Schistosoma mansoni serine/threonine protein kinase 0.2935 0.2827 0.7295
Loa Loa (eye worm) hypothetical protein 0.0263 0.0025 0.0023
Echinococcus granulosus casein kinase ii subunit alpha 0.0263 0.0024 0.0022
Echinococcus multilocularis cyclin dependent kinase 1 0.0476 0.0248 0.0246
Trichomonas vaginalis CAMK family protein kinase 0.0378 0.0145 0.1347
Echinococcus granulosus peroxidasin 0.0298 0.0061 0.0059
Trypanosoma brucei Casein kinase II 0.0263 0.0024 0.002
Onchocerca volvulus 0.0654 0.0435 0.0589
Loa Loa (eye worm) hypothetical protein 0.0263 0.0025 0.0023
Onchocerca volvulus 0.0931 0.0725 0.1006
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Entamoeba histolytica protein kinase, putative 0.0263 0.0025 0.0189
Echinococcus multilocularis fibroblast growth factor receptor 4 0.1485 0.1306 0.1304
Trichomonas vaginalis conserved hypothetical protein 0.0263 0.0025 0.0231
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0437 0.0207 0.0205
Schistosoma mansoni serine/threonine protein kinase 0.0332 0.0097 0.0244
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.068 0.0462 0.1186
Loa Loa (eye worm) TK/FER protein kinase 0.0836 0.0626 0.0624
Trichomonas vaginalis AGC family protein kinase 0.0785 0.0572 0.5328
Trichomonas vaginalis STE family protein kinase 0.0404 0.0173 0.1607
Entamoeba histolytica tyrosine kinase, putative 0.0263 0.0025 0.0189
Schistosoma mansoni serine/threonine protein kinase 0.233 0.2192 0.5655
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0263 0.0025 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0378 0.0145 0.0368
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Loa Loa (eye worm) TK protein kinase 0.0263 0.0025 0.0023
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1568 0.1393 0.1391
Loa Loa (eye worm) TK/FAK protein kinase 0.3978 0.392 0.3919
Echinococcus multilocularis dual specificity protein kinase clk2 0.1133 0.0937 0.0935
Echinococcus granulosus retinal guanylyl cyclase 2 0.0263 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.1064 0.0864 0.0862
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0041 0.0386
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0451 0.0222 0.0218
Echinococcus granulosus N chimaerin 0.04 0.0168 0.0166
Echinococcus granulosus calcium dependent protein kinase 0.0421 0.019 0.0188
Trypanosoma brucei polo-like protein kinase 0.0347 0.0112 0.0108
Schistosoma mansoni tyrosine kinase 0.0736 0.0521 0.1339
Brugia malayi Protein kinase domain containing protein 0.0263 0.0025 0.0023
Schistosoma mansoni growth factor receptor-bound protein 0.0433 0.0203 0.0518
Echinococcus multilocularis rho associated protein kinase 0.068 0.0461 0.0459
Entamoeba histolytica protein kinase, putative 0.0263 0.0025 0.0189
Schistosoma mansoni serine/threonine-protein kinase 0.0372 0.0138 0.0352
Echinococcus granulosus activated cdc42 kinase 1 0.175 0.1583 0.1582
Leishmania major protein kinase, putative 0.0263 0.0025 0.0021
Echinococcus granulosus serine:threonine protein kinase 0.0371 0.0137 0.0135
Brugia malayi protein C17H12.11 0.0618 0.0397 0.0395
Schistosoma mansoni ste20-related kinase 0.038 0.0147 0.0374
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.1383 0.1199 0.1197
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0747 0.0531 0.1367
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0404 0.0173 0.0171
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Brugia malayi Immunoglobulin I-set domain containing protein 0.3719 0.3648 0.3647
Entamoeba histolytica serine/threonine kinase, putative 0.0263 0.0025 0.0189
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0244 0.0004 0.0024
Plasmodium falciparum serine/threonine protein kinase, putative 0.0695 0.0478 0.4707
Loa Loa (eye worm) hypothetical protein 0.0946 0.074 0.0738
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0263 0.0025 0.0058
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1487 0.1308 0.1306
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0654 0.0435 0.0433
Echinococcus granulosus NCK adaptor protein 0.0417 0.0185 0.0183
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0263 0.0025 0.0023
Loa Loa (eye worm) TK/FER protein kinase 0.0498 0.0271 0.0269
Echinococcus multilocularis tyrosine protein kinase pr2 0.0263 0.0025 0.0023
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.1206 0.1013 0.101
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.206 0.1908 0.1907
Plasmodium falciparum calcium-dependent protein kinase 1 0.0609 0.0387 0.3809
Schistosoma mansoni growth factor receptor-bound protein 0.0417 0.0185 0.0473
Schistosoma mansoni serine/threonine protein kinase 0.0618 0.0396 0.1018
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Loa Loa (eye worm) hypothetical protein 0.1532 0.1355 0.1353
Schistosoma mansoni tyrosine kinase 0.0263 0.0025 0.0058
Leishmania major protein kinase A catalytic subunit isoform 2 0.0814 0.0602 0.0598
Loa Loa (eye worm) hypothetical protein 0.0263 0.0025 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0347 0.0112 0.0284
Brugia malayi Protein kinase domain containing protein 0.0366 0.0132 0.013
Echinococcus multilocularis serine:threonine protein kinase 0.0371 0.0137 0.0135
Brugia malayi bone morphogenetic protein type 1 receptor 0.0988 0.0785 0.0783
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0747 0.0531 0.0528
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0609 0.0387 0.3809
Echinococcus multilocularis casein kinase I alpha 0.0654 0.0435 0.0433
Echinococcus multilocularis activin receptor type 0.4152 0.4103 0.4102
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0244 0.0005 0.0001
Brugia malayi Variant SH3 domain containing protein 0.0417 0.0185 0.0183
Trichomonas vaginalis STE family protein kinase 0.1264 0.1074 1
Echinococcus multilocularis N chimaerin 0.04 0.0168 0.0166
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.1028 0.0826 0.0824
Giardia lamblia Kinase, CMGC CK2 0.0263 0.0024 0.0186
Entamoeba histolytica protein kinase domain containing protein 0.0311 0.0075 0.061
Loa Loa (eye worm) TK/KIN16 protein kinase 0.3719 0.3648 0.3647
Brugia malayi Protein kinase domain containing protein 0.175 0.1583 0.1582
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0609 0.0387 0.0385
Echinococcus granulosus titin 0.0418 0.0187 0.0185
Giardia lamblia Kinase 0.0263 0.0025 0.0194
Echinococcus multilocularis cyclin dependent kinase 1 0.0476 0.0248 0.0246
Echinococcus granulosus expressed protein 0.0244 0.0004 0.0002
Echinococcus granulosus insulin receptor 0.1533 0.1356 0.1354
Echinococcus multilocularis dual specificity 0.0306 0.0069 0.0067
Brugia malayi C1-like domain containing protein 0.1131 0.0934 0.0933
Schistosoma mansoni tyrosine kinase 0.0263 0.0025 0.0058
Schistosoma mansoni tyrosine kinase 0.2298 0.2158 0.5567
Giardia lamblia Kinase, AGC PKA 0.0814 0.0602 0.5591
Loa Loa (eye worm) hypothetical protein 0.0573 0.0349 0.0347
Entamoeba histolytica protein kinase, putative 0.0263 0.0025 0.0189
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0679 0.046 0.0458
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.033 0.0094 0.0092
Echinococcus multilocularis tyrosine protein kinase csk 0.0263 0.0025 0.0023
Brugia malayi Protein kinase domain containing protein 0.0263 0.0025 0.0023
Echinococcus multilocularis activated cdc42 kinase 1 0.175 0.1583 0.1582
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Loa Loa (eye worm) hypothetical protein 0.0778 0.0564 0.0562
Onchocerca volvulus 0.0989 0.0786 0.1095
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0244 0.0005 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0591 0.0368 0.0945
Schistosoma mansoni tyrosine kinase 0.0836 0.0625 0.1608
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.1383 0.1199 0.1196
Schistosoma mansoni protein kinase 0.0695 0.0478 0.1228
Entamoeba histolytica protein kinase domain containing protein 0.0451 0.0222 0.1833
Schistosoma mansoni serine/threonine protein kinase 0.0306 0.0069 0.0174
Brugia malayi Prion-like- 0.0295 0.0058 0.0055
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus granulosus activated cdc42 kinase 1 0.175 0.1583 0.1582
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0025 0.0189
Echinococcus granulosus serine:threonine protein kinase 3 0.0437 0.0207 0.0205
Entamoeba histolytica protein kinase, putative 0.0263 0.0025 0.0189
Entamoeba histolytica serine/threonine kinase, putative 0.0263 0.0025 0.0189
Entamoeba histolytica protein kinase, putative 0.0609 0.0387 0.3215
Schistosoma mansoni protein kinase 0.2591 0.2466 0.6362
Loa Loa (eye worm) hypothetical protein 0.0298 0.0061 0.0059
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0414 0.0182 0.1698
Entamoeba histolytica hypothetical protein 0.0263 0.0025 0.0189
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0025 0.0189
Trichomonas vaginalis STE family protein kinase 0.0245 0.0006 0.0054
Brugia malayi hypothetical protein 0.0498 0.0271 0.0269
Loa Loa (eye worm) hypothetical protein 0.0288 0.0051 0.0049
Echinococcus multilocularis Immunoglobulin 0.0679 0.046 0.0458
Trichomonas vaginalis CAMK family protein kinase 0.0378 0.0145 0.1347
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Loa Loa (eye worm) hypothetical protein 0.0777 0.0564 0.0562
Echinococcus multilocularis raf serine:threonine protein kinase 0.0429 0.0199 0.0197
Brugia malayi Egg laying defective protein 4 0.0301 0.0064 0.0062
Loa Loa (eye worm) hypothetical protein 0.1196 0.1002 0.1
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Trichomonas vaginalis CAMK family protein kinase 0.0378 0.0145 0.1347
Schistosoma mansoni serine/threonine protein kinase 0.0334 0.0099 0.025
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0451 0.0222 0.022
Loa Loa (eye worm) hypothetical protein 0.0572 0.0349 0.0347
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.233 0.2192 0.3116
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0651 0.0432 0.043
Echinococcus multilocularis serine:threonine protein kinase N2 0.191 0.1752 0.175
Brugia malayi cyclin-dependent kinase 7 homolog 0.0662 0.0443 0.0441
Schistosoma mansoni protein kinase 0.2591 0.2466 0.6362
Schistosoma mansoni serine/threonine protein kinase 0.1448 0.1267 0.3267
Entamoeba histolytica hypothetical protein 0.0266 0.0028 0.0216
Schistosoma mansoni hypothetical protein 0.0263 0.0025 0.0058
Plasmodium falciparum calcium-dependent protein kinase 5 0.0609 0.0387 0.3809
Brugia malayi Protein kinase domain containing protein 0.0651 0.0432 0.043
Schistosoma mansoni ephrin receptor 0.0335 0.01 0.0252
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0244 0.0005 0.0001
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0024 0.0182
Trypanosoma cruzi casein kinase, putative 0.0654 0.0435 0.0431
Echinococcus granulosus tyrosine protein kinase csk 0.0263 0.0025 0.0023
Brugia malayi Protein kinase domain containing protein 0.0498 0.0271 0.0269
Entamoeba histolytica ankyrin repeat protein 0.0263 0.0025 0.0189
Entamoeba histolytica ankyrin repeat protein 0.0263 0.0025 0.0189
Onchocerca volvulus 0.0498 0.0271 0.0354
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0476 0.0248 0.0244
Echinococcus granulosus serine:threonine kinase SAD 1 0.0378 0.0145 0.0143
Loa Loa (eye worm) TK/ACK protein kinase 0.0263 0.0025 0.0023
Schistosoma mansoni nephrin 0.033 0.0094 0.0238
Echinococcus granulosus rho-associated protein kinase 1 0.068 0.0461 0.0459
Trichomonas vaginalis CAMK family protein kinase 0.0378 0.0145 0.1347
Schistosoma mansoni tyrosine kinase 0.0263 0.0025 0.0058
Brugia malayi map kinase activated protein kinase protein 2 0.0591 0.0368 0.0366
Echinococcus granulosus neuroglian 0.0874 0.0665 0.0663
Trichomonas vaginalis AGC family protein kinase 0.0286 0.0049 0.0452
Echinococcus multilocularis growth factor receptor bound protein 2 0.0417 0.0185 0.0183
Echinococcus granulosus tyrosine protein kinase csk 0.0263 0.0025 0.0023
Echinococcus granulosus tyrosine protein kinase Lyn 0.1325 0.1138 0.1136
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1206 0.1013 0.1011
Echinococcus granulosus casein kinase I gamma 0.0389 0.0156 0.0154
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0263 0.0025 0.0023
Brugia malayi Fes/CIP4 homology domain containing protein 0.0911 0.0704 0.0702
Loa Loa (eye worm) TK protein kinase 0.0263 0.0025 0.0023
Trypanosoma cruzi casein kinase, putative 0.0654 0.0435 0.0431
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.1137 0.0941 0.0939
Plasmodium falciparum glycogen synthase kinase 3 0.1206 0.1013 1
Schistosoma mansoni protein kinase 0.0263 0.0025 0.0058
Schistosoma mansoni tyrosine kinase 0.0263 0.0025 0.0058
Brugia malayi Cam kinase protein 1 0.0609 0.0387 0.0385
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0609 0.0387 0.0385
Entamoeba histolytica protein kinase, putative 0.0695 0.0478 0.3973
Schistosoma mansoni tyrosine kinase 0.0263 0.0025 0.0058
Schistosoma mansoni serine/threonine protein kinase 0.0332 0.0097 0.0244
Onchocerca volvulus 0.0747 0.0531 0.0728
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0263 0.0025 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Giardia lamblia Kinase, CMGC MAPK 0.0244 0.0005 0.0007
Echinococcus multilocularis contactin neuroglian septate junction protein 0.033 0.0094 0.0092
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0244 0.0005 0.0001
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0244 0.0005 0.0031
Schistosoma mansoni protein kinase 0.0263 0.0025 0.0058
Echinococcus granulosus hemicentin 1 0.0295 0.0058 0.0055
Echinococcus multilocularis neuroglian 0.0874 0.0665 0.0663
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0476 0.0248 0.0246
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0404 0.0173 0.0171
Echinococcus granulosus casein kinase I alpha 0.0654 0.0435 0.0433
Echinococcus multilocularis tyrosine protein kinase Fgr 0.1137 0.0941 0.0939
Schistosoma mansoni serine/threonine kinase 0.0601 0.0379 0.0974
Entamoeba histolytica protein kinase, putative 0.0695 0.0478 0.3973
Giardia lamblia Kinase, CK1 Casein kinase 0.0654 0.0435 0.4025
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0245 0.0006 0.0031
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0695 0.0478 0.0476
Loa Loa (eye worm) TK/DDR protein kinase 0.0414 0.0183 0.018
Entamoeba histolytica receptor protein kinase, putative 0.0263 0.0025 0.0189
Trichomonas vaginalis AGC family protein kinase 0.0785 0.0572 0.5328
Echinococcus granulosus dual specificity 0.0306 0.0069 0.0067
Loa Loa (eye worm) AGC/PKG protein kinase 0.0301 0.0064 0.0062
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0263 0.0025 0.0189
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0404 0.0173 0.0171
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.1448 0.1267 0.1265
Trichomonas vaginalis CAMK family protein kinase 0.0378 0.0145 0.1347
Schistosoma mansoni serine/threonine protein kinase 0.0263 0.0025 0.0058
Entamoeba histolytica protein kinase, putative 0.0263 0.0025 0.0189
Brugia malayi Serine/threonine-protein kinase SULU 0.2935 0.2827 0.2825
Loa Loa (eye worm) hypothetical protein 0.0295 0.0058 0.0055
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0263 0.0025 0.0231
Loa Loa (eye worm) CAMK/PIM protein kinase 0.233 0.2192 0.219
Schistosoma mansoni serine/threonine protein kinase 0.0554 0.0329 0.0845
Loa Loa (eye worm) hypothetical protein 0.0295 0.0058 0.0055
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus multilocularis slit 2 protein 0.0277 0.0039 0.0037
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0769 0.0555 0.0553
Loa Loa (eye worm) AUR protein kinase 0.0695 0.0478 0.0476
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0778 0.0564 0.0562
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0955 0.075 0.0748
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.1206 0.1013 1
Entamoeba histolytica hypothetical protein 0.0266 0.0027 0.0208
Brugia malayi Protein kinase domain containing protein 0.0263 0.0025 0.0023
Brugia malayi intracellular kinase 0.1206 0.1013 0.1011
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0326 0.009 0.0088
Entamoeba histolytica hypothetical protein 0.0263 0.0025 0.0189
Plasmodium falciparum calcium-dependent protein kinase 4 0.0609 0.0387 0.3809
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0814 0.0602 0.5936
Brugia malayi Protein kinase domain 0.0404 0.0173 0.0171
Entamoeba histolytica tyrosine kinase, putative 0.0263 0.0025 0.0189
Schistosoma mansoni protein kinase 0.0366 0.0132 0.0336
Loa Loa (eye worm) hypothetical protein 0.0747 0.0531 0.0529
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Brugia malayi Protein kinase domain containing protein 0.0263 0.0025 0.0023
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0263 0.0025 0.0189
Brugia malayi protein kinase C II. 0.0769 0.0555 0.0553
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0404 0.0173 0.0171
Onchocerca volvulus 0.6895 0.6979 1
Trichomonas vaginalis CMGC family protein kinase 0.0476 0.0248 0.2308
Trichomonas vaginalis CMGC family protein kinase 0.0244 0.0005 0.0044
Trypanosoma cruzi cdc2-related kinase 1 0.0476 0.0248 0.0244
Plasmodium falciparum protein kinase, putative 0.0263 0.0025 0.0229
Trichomonas vaginalis STE family protein kinase 0.0404 0.0173 0.1607
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0263 0.0025 0.0189
Loa Loa (eye worm) TK protein kinase 0.0263 0.0025 0.0023
Entamoeba histolytica serine/threonine kinase, putative 0.0263 0.0025 0.0189
Entamoeba histolytica protein kinase, putative 0.0263 0.0025 0.0189
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0378 0.0145 0.0141
Loa Loa (eye worm) hypothetical protein 0.0277 0.0039 0.0037
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0814 0.0602 0.5936
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0452 0.0222 0.022
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0476 0.0248 0.0246
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0609 0.0387 0.0385
Echinococcus granulosus serine/threonine protein kinase 0.0372 0.0138 0.0136
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.082 0.0609 0.0607
Trichomonas vaginalis CMGC family protein kinase 0.0244 0.0005 0.0044
Trypanosoma cruzi casein kinase, putative 0.0654 0.0435 0.0431
Echinococcus multilocularis TGF beta receptor type 1 0.0912 0.0705 0.0703
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0332 0.0097 0.0095
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0334 0.0099 0.0097
Plasmodium falciparum tyrosine kinase-like protein 0.0263 0.0025 0.0229
Trypanosoma brucei cdc2-related kinase 1 0.0476 0.0248 0.0244
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0245 0.0006 0.0002
Entamoeba histolytica protein kinase, putative 0.0263 0.0025 0.0189
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0263 0.0025 0.0023
Brugia malayi Protein kinase domain containing protein 0.1133 0.0937 0.0935
Entamoeba histolytica protein kinase, putative 0.1383 0.1199 1
Schistosoma mansoni cell adhesion molecule 0.033 0.0094 0.0238
Brugia malayi p70 ribosomal S6 kinase beta 0.0739 0.0524 0.0522
Onchocerca volvulus 0.0274 0.0036 0.0016
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.2677 0.2556 0.2555
Echinococcus multilocularis cyclin dependent kinase 5 0.0476 0.0248 0.0246
Echinococcus granulosus beta-adrenergic receptor kinase 0.0332 0.0097 0.0095
Echinococcus granulosus MAM 0.0345 0.011 0.0108
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0312 0.0076 0.0074
Echinococcus multilocularis dual specificity 0.1383 0.1199 0.1197
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0025 0.0189
Trichomonas vaginalis CAMK family protein kinase 0.0347 0.0112 0.1045
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.1133 0.0937 0.0933
Schistosoma mansoni protein kinase 0.0263 0.0025 0.0058
Brugia malayi Immunoglobulin I-set domain containing protein 0.0295 0.0058 0.0055
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0377 0.0144 0.0142
Onchocerca volvulus 0.0345 0.011 0.0123
Brugia malayi Protein kinase domain containing protein 0.0435 0.0205 0.0203
Echinococcus multilocularis tyrosine protein kinase shark 0.0736 0.0521 0.0519
Schistosoma mansoni septate junction protein 0.0295 0.0058 0.0143
Echinococcus granulosus cyclin dependent kinase 9 0.044 0.021 0.0208
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.1137 0.0941 0.0939
Trichomonas vaginalis CMGC family protein kinase 0.0263 0.0024 0.0223
Echinococcus granulosus epidermal growth factor receptor 0.1121 0.0924 0.0922
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.1383 0.1199 0.1196
Schistosoma mansoni protein tyrosine kinase 0.0263 0.0025 0.0058
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.028 0.0042 0.004
Echinococcus multilocularis casein kinase I delta 0.0654 0.0435 0.0433
Entamoeba histolytica protein kinase, putative 0.0785 0.0572 0.4762
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0747 0.0531 0.1367
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.028 0.0042 0.004
Loa Loa (eye worm) hypothetical protein 0.0752 0.0537 0.0535
Entamoeba histolytica protein kinase, putative 0.0263 0.0025 0.0189
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0025 0.0189
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0025 0.0189
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0695 0.0478 0.3973
Brugia malayi Immunoglobulin I-set domain containing protein 0.0295 0.0058 0.0055
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0263 0.0025 0.0058
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Schistosoma mansoni serine/threonine protein kinase 0.0244 0.0004 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.044 0.021 0.0537
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.2252 0.211 0.2109
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0347 0.0112 0.011
Echinococcus granulosus contactin 0.033 0.0094 0.0092
Echinococcus multilocularis protein KINase family member (kin 25) 0.0836 0.0625 0.0623
Trichomonas vaginalis AGC family protein kinase 0.0242 0.0002 0.002
Schistosoma mansoni tyrosine kinase 0.0263 0.0025 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.0347 0.0112 0.1045
Entamoeba histolytica protein kinase, putative 0.0263 0.0025 0.0189
Echinococcus multilocularis tyrosine protein kinase csk 0.0263 0.0025 0.0023
Echinococcus granulosus tyrosine kinase 0.0263 0.0025 0.0023
Entamoeba histolytica protein kinase, putative 0.0263 0.0025 0.0189
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0451 0.0222 0.0218
Schistosoma mansoni serine/threonine protein kinase 0.1133 0.0937 0.2415
Trichomonas vaginalis conserved hypothetical protein 0.0263 0.0025 0.0231
Toxoplasma gondii aurora kinase 0.0695 0.0478 0.4707
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0263 0.0025 0.0231
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0609 0.0387 0.0385
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.6157 0.6205 0.6204
Echinococcus multilocularis serine:threonine protein kinase 38 0.0601 0.0379 0.0377
Schistosoma mansoni serine/threonine RGC 0.0263 0.0025 0.0058
Echinococcus granulosus growth factor receptor bound protein 2 0.0433 0.0203 0.0201
Brugia malayi protein kinase C3,putative 0.0446 0.0216 0.0214
Entamoeba histolytica tyrosine kinase, putative 0.0263 0.0025 0.0189
Echinococcus multilocularis rac serine:threonine kinase 0.0372 0.0138 0.0136
Echinococcus granulosus tyrosine protein kinase Fyn 0.1137 0.0941 0.0939
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.1448 0.1267 0.1265
Schistosoma mansoni protein kinase 0.0912 0.0705 0.1816
Brugia malayi Immunoglobulin I-set domain containing protein 0.0472 0.0244 0.0242
Echinococcus multilocularis tyrosine protein kinase ABL1 0.2592 0.2467 0.2465
Echinococcus granulosus c src tyrosine kinase 0.068 0.0462 0.046
Echinococcus granulosus c-Jun N-terminal kinases 0.3253 0.316 0.3159
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.1982 0.1827 0.1825
Loa Loa (eye worm) SRC-1 0.1137 0.0941 0.0939
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0452 0.0223 0.0221
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1631 0.1459 0.1457
Leishmania major protein kinase, putative 0.0245 0.0006 0.0002
Giardia lamblia Kinase, CMGC CDK 0.0476 0.0248 0.2279
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0814 0.0602 0.06
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0263 0.0025 0.0023
Brugia malayi Protein kinase domain containing protein 0.0371 0.0137 0.0135
Schistosoma mansoni serine/threonine protein kinase 0.0814 0.0602 0.155
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0476 0.0248 0.0244
Echinococcus multilocularis neuroglian 0.033 0.0094 0.0092
Onchocerca volvulus 0.038 0.0147 0.0176
Echinococcus multilocularis beta adrenergic receptor kinase 0.0332 0.0097 0.0095
Schistosoma mansoni serine/threonine protein kinase 0.1631 0.1459 0.3763
Onchocerca volvulus 0.1206 0.1013 0.1421
Brugia malayi integrin-linked kinase 0.0263 0.0025 0.0023
Giardia lamblia Aurora kinase 0.0695 0.0478 0.4428
Echinococcus granulosus integrin linked protein kinase 0.0263 0.0025 0.0023
Entamoeba histolytica tyrosine kinase, putative 0.0263 0.0025 0.0189
Brugia malayi RhoGAP domain containing protein 0.04 0.0168 0.0166
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0814 0.0602 0.0598
Loa Loa (eye worm) TK protein kinase 0.0955 0.075 0.0748
Brugia malayi Guanylyl cyclase protein 23 0.0263 0.0025 0.0023
Loa Loa (eye worm) TK/Met protein kinase 0.0263 0.0025 0.0023
Echinococcus multilocularis roundabout 2 0.033 0.0094 0.0092
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.1206 0.1013 0.1011
Echinococcus granulosus Immunoglobulin 0.0679 0.046 0.0458
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.033 0.0094 0.0092
Plasmodium falciparum calcium-dependent protein kinase 2 0.0609 0.0387 0.3809
Brugia malayi hypothetical protein 0.0747 0.0531 0.0529
Schistosoma mansoni tyrosine kinase 0.1137 0.0941 0.2425
Echinococcus granulosus roundabout 2 0.1008 0.0806 0.0804
Echinococcus multilocularis serine:threonine protein kinase 0.0371 0.0137 0.0135
Loa Loa (eye worm) hypothetical protein 0.0295 0.0058 0.0055
Echinococcus multilocularis ephrin type A receptor 4 A 0.0335 0.01 0.0098
Brugia malayi hypothetical protein 0.0618 0.0397 0.0395
Loa Loa (eye worm) hypothetical protein 0.0836 0.0625 0.0623
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0747 0.0531 0.0528
Giardia lamblia Protein 21.1 0.0263 0.0025 0.0194
Entamoeba histolytica protein kinase, putative 0.0266 0.0028 0.0216
Loa Loa (eye worm) TK/RYK protein kinase 0.0263 0.0025 0.0023
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.1448 0.1267 0.1265
Echinococcus granulosus casein kinase i 0.0654 0.0435 0.0433
Entamoeba histolytica protein kinase domain containing protein 0.0306 0.0069 0.0562
Schistosoma mansoni protein kinase 0.0263 0.0024 0.0056
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0025 0.0189
Echinococcus multilocularis protein kinase c iota type 0.086 0.065 0.0648
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0025 0.0189
Entamoeba histolytica hypothetical protein 0.0263 0.0025 0.0189
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.1206 0.1013 0.2611
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0609 0.0387 0.0385
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0417 0.0185 0.0183
Echinococcus granulosus tyrosine protein kinase ABL1 0.2592 0.2467 0.2465
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Loa Loa (eye worm) hypothetical protein 0.0618 0.0397 0.0395
Echinococcus multilocularis roundabout 2 0.1008 0.0806 0.0804
Echinococcus granulosus ephrin type A receptor 4 A 0.0335 0.01 0.0098
Toxoplasma gondii casein kinase I 0.0654 0.0435 0.4281
Loa Loa (eye worm) hypothetical protein 0.0378 0.0145 0.0143
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0025 0.0189
Giardia lamblia Kinase, NEK 0.0263 0.0025 0.0194
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0814 0.0602 0.06
Loa Loa (eye worm) hypothetical protein 0.0345 0.011 0.0108
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0472 0.0244 0.0242
Trichomonas vaginalis CAMK family protein kinase 0.0378 0.0145 0.1347
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0708 0.0491 0.0489
Loa Loa (eye worm) hypothetical protein 0.439 0.4352 0.4351
Trichomonas vaginalis CMGC family protein kinase 0.0476 0.0248 0.2308
Giardia lamblia Kinase, NEK 0.0303 0.0066 0.058
Giardia lamblia Kinase, CMGC GSK 0.1206 0.1013 0.9434
Loa Loa (eye worm) hypothetical protein 0.0498 0.0271 0.0269
Echinococcus granulosus protein kinase 0.0993 0.079 0.0788
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0806 0.0594 0.0592
Echinococcus granulosus twitchin 0.1062 0.0862 0.086
Entamoeba histolytica protein kinase, putative 0.0263 0.0025 0.0189
Echinococcus granulosus serine:threonine protein kinase N2 0.191 0.1752 0.175
Echinococcus granulosus tyrosine protein kinase 0.0263 0.0025 0.0023
Echinococcus multilocularis casein kinase I delta 0.0654 0.0435 0.0433
Brugia malayi hypothetical protein 0.0263 0.0025 0.0023
Entamoeba histolytica protein kinase, putative 0.0244 0.0004 0.0016
Echinococcus multilocularis myosin iiia 0.0245 0.0006 0.0004
Plasmodium vivax unspecified product 0.0263 0.0024 0.0221
Entamoeba histolytica protein kinase, putative 0.0422 0.0191 0.1581
Schistosoma mansoni serine/threonine protein kinase 0.0601 0.0379 0.0974
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0702 0.0485 0.0483
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.2935 0.2827 0.2825
Brugia malayi Protein kinase domain containing protein 0.0476 0.0248 0.0246
Loa Loa (eye worm) AUR protein kinase 0.0695 0.0478 0.0476
Trichomonas vaginalis AGC family protein kinase 0.0601 0.0379 0.3531
Plasmodium falciparum protein kinase 5 0.0476 0.0248 0.2434
Loa Loa (eye worm) TK/FER protein kinase 0.0498 0.0271 0.0269
Echinococcus multilocularis transfer RNA-Thr 0.175 0.1583 0.1582
Trichomonas vaginalis conserved hypothetical protein 0.0263 0.0025 0.0231
Brugia malayi SH2 domain containing protein 0.0836 0.0626 0.0624
Loa Loa (eye worm) hypothetical protein 0.0777 0.0564 0.0562
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0303 0.0066 0.0638
Echinococcus granulosus TGF beta receptor type 1 0.0912 0.0705 0.0703
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0934 0.0728 0.0726
Loa Loa (eye worm) AGC/AKT protein kinase 0.0785 0.0572 0.057
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0609 0.0387 0.0385
Brugia malayi Variant SH3 domain containing protein 0.04 0.0168 0.0166
Brugia malayi Protein kinase domain containing protein 0.1803 0.1639 0.1637
Brugia malayi Protein kinase domain containing protein 0.082 0.0609 0.0607
Trichomonas vaginalis AGC family protein kinase 0.0785 0.0572 0.5328
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Schistosoma mansoni neuroglian 0.033 0.0094 0.0238
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0601 0.0379 0.0377
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0025 0.0189
Echinococcus granulosus tyrosine protein kinase HCK 0.0721 0.0504 0.0502
Schistosoma mansoni serine/threonine protein kinase 0.0378 0.0145 0.0368
Schistosoma mansoni serine/threonine protein kinase 0.191 0.1752 0.4518
Brugia malayi Protein kinase domain containing protein 0.0263 0.0025 0.0023
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0451 0.0222 0.2175
Echinococcus granulosus tyrosine protein kinase Btk29A 0.2463 0.2331 0.233
Echinococcus multilocularis insulin receptor 0.1533 0.1356 0.1354
Echinococcus multilocularis cyclin dependent kinase 19 0.1803 0.1639 0.1637
Echinococcus granulosus tyrosine protein kinase Srms 0.0953 0.0748 0.0746
Onchocerca volvulus 0.037 0.0136 0.016
Entamoeba histolytica tyrosin kinase, putative 0.0263 0.0025 0.0189
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0279 0.0041 0.0039
Echinococcus multilocularis NCK adaptor protein 0.0433 0.0203 0.0201
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.1081 0.0882 0.0878
Giardia lamblia Kinase, NEK 0.0303 0.0066 0.058
Loa Loa (eye worm) TK/FER protein kinase 0.0263 0.0025 0.0023
Trichomonas vaginalis CMGC family protein kinase 0.1206 0.1013 0.9436
Brugia malayi Protein kinase domain containing protein 0.1533 0.1356 0.1354
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.2677 0.2556 0.2555
Echinococcus granulosus protein tyrosine kinase 0.3934 0.3874 0.3873
Plasmodium vivax casein kinase 1, putative 0.0654 0.0435 0.4281
Trypanosoma cruzi Protein kinase B 0.0372 0.0138 0.0134
Echinococcus multilocularis peroxidasin 0.0298 0.0061 0.0059
Schistosoma mansoni tyrosine kinase 0.1485 0.1306 0.3368
Brugia malayi STE20-like kinase MST 0.0437 0.0207 0.0205
Echinococcus multilocularis 0.0946 0.074 0.0738
Echinococcus granulosus cGMP dependent protein kinase 0.0301 0.0064 0.0062
Echinococcus multilocularis serine:threonine protein kinase N2 0.1309 0.1121 0.1119
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.044 0.021 0.0208
Entamoeba histolytica protein kinase domain containing protein 0.1383 0.1199 1
Brugia malayi serine/threonine protein kinase 6 0.0695 0.0478 0.0476
Brugia malayi Furin-like cysteine rich region family protein 0.1121 0.0924 0.0922
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Giardia lamblia Kinase, CMGC CDK 0.0476 0.0248 0.2279
Trichomonas vaginalis CAMK family protein kinase 0.0347 0.0112 0.1045
Schistosoma mansoni vav2 0.0447 0.0217 0.0554
Brugia malayi Protein kinase domain containing protein 0.0334 0.0099 0.0097
Echinococcus multilocularis death associated protein kinase 1 0.9299 0.95 0.95
Loa Loa (eye worm) TK/EGFR protein kinase 0.1121 0.0924 0.0922
Echinococcus granulosus tyrosine protein kinase csk 0.0263 0.0025 0.0023
Brugia malayi Immunoglobulin I-set domain containing protein 0.033 0.0094 0.0092
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0326 0.009 0.0086
Echinococcus multilocularis casein kinase ii subunit alpha 0.0263 0.0024 0.0022
Schistosoma mansoni tyrosine kinase 0.0502 0.0275 0.0704
Schistosoma mansoni cell adhesion molecule 0.0813 0.0601 0.1546
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus multilocularis tyrosine protein kinase Srms 0.0955 0.075 0.0748
Echinococcus granulosus titin 0.0418 0.0187 0.0185
Echinococcus granulosus dual specificity mitogen activated protein 0.1264 0.1074 0.1072
Echinococcus multilocularis tyrosine protein kinase HCK 0.0721 0.0504 0.0502
Echinococcus granulosus mitogen activated protein kinase 3 0.0244 0.0005 0.0003
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Loa Loa (eye worm) hypothetical protein 0.0973 0.0769 0.0767
Echinococcus granulosus mitogen activated protein kinase 0.0244 0.0005 0.0003
Schistosoma mansoni kinase 0.044 0.021 0.0537
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0498 0.0271 0.2244
Trichomonas vaginalis AGC family protein kinase 0.0647 0.0427 0.3981
Trichomonas vaginalis conserved hypothetical protein 0.0263 0.0025 0.0231
Schistosoma mansoni tyrosine protein kinase 0.0263 0.0025 0.0058
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.1264 0.1074 0.1072
Trichomonas vaginalis CMGC family protein kinase 0.0476 0.0248 0.2308
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0263 0.0025 0.0189
Entamoeba histolytica tyrosin kinase, putative 0.0311 0.0075 0.061
Trichomonas vaginalis CAMK family protein kinase 0.0378 0.0145 0.1347
Loa Loa (eye worm) hypothetical protein 0.1097 0.0899 0.0897
Schistosoma mansoni serine/threonine protein kinase 0.0244 0.0005 0.0007
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0312 0.0076 0.0074
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0263 0.0024 0.0022
Schistosoma mansoni tyrosine kinase 0.0263 0.0025 0.0058
Entamoeba histolytica protein kinase, putative 0.0263 0.0025 0.0189
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.2935 0.2827 0.2825
Trichomonas vaginalis CMGC family protein kinase 0.0263 0.0024 0.0223
Plasmodium vivax glycogen synthase kinase 3, putative 0.1206 0.1013 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0609 0.0387 0.3809
Schistosoma mansoni ephrin receptor 0.0298 0.0061 0.0153
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0347 0.0112 0.0108
Loa Loa (eye worm) hypothetical protein 0.0263 0.0025 0.0023
Trichomonas vaginalis CMGC family protein kinase 0.1206 0.1013 0.9436
Schistosoma mansoni tyrosine kinase 0.0702 0.0485 0.1248
Brugia malayi Temporarily assigned gene name protein 59 0.0747 0.0531 0.0529
Entamoeba histolytica casein kinase 1, putative 0.0654 0.0435 0.3613
Loa Loa (eye worm) hypothetical protein 0.0943 0.0738 0.0736
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.1133 0.0937 0.0933
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0695 0.0478 0.3973
Echinococcus multilocularis dual specificity 0.0306 0.0069 0.0067
Entamoeba histolytica cysteine surface protein, putative 0.0263 0.0025 0.0189
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0422 0.0191 0.1581
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0263 0.0025 0.0189
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0372 0.0138 0.0134
Leishmania major casein kinase, putative 0.0654 0.0435 0.0431
Schistosoma mansoni protein kinase 0.1264 0.1074 0.2768
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0417 0.0185 0.0473
Brugia malayi Protein kinase domain containing protein 0.0263 0.0025 0.0023
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0263 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0679 0.046 0.0458
Echinococcus granulosus serine:threonine protein kinase N2 0.1309 0.1121 0.1119
Entamoeba histolytica protein kinase, putative 0.1383 0.1199 1
Loa Loa (eye worm) hypothetical protein 0.0973 0.0769 0.0767
Loa Loa (eye worm) gastrulation defective protein 1 0.1615 0.1442 0.144
Echinococcus multilocularis aurora kinase A 0.0695 0.0478 0.0476
Echinococcus multilocularis tyrosine protein kinase Abl 0.1481 0.1301 0.1299
Loa Loa (eye worm) hypothetical protein 0.0573 0.0349 0.0347
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.2591 0.2466 0.2464
Trichomonas vaginalis CAMK family protein kinase 0.0378 0.0145 0.1347
Entamoeba histolytica protein kinase, putative 0.0785 0.0572 0.4762
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0378 0.0145 0.0141
Echinococcus granulosus kinase suppressor of Ras 1 0.0263 0.0025 0.0023
Entamoeba histolytica tyrosine kinase, putative 0.0263 0.0025 0.0189
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0366 0.0132 0.013
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus granulosus Protein kinase C brain isozyme 0.0813 0.0601 0.0599
Echinococcus granulosus protein kinase c epsilon type 0.0769 0.0555 0.0553
Trypanosoma brucei aurora B kinase 0.0695 0.0478 0.0474
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0306 0.0069 0.067
Giardia lamblia Kinase, NEK 0.0263 0.0025 0.0194
Trichomonas vaginalis CAMK family protein kinase 0.0378 0.0145 0.1347
Echinococcus granulosus protein kinase C gamma type 0.0647 0.0427 0.0425
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0626 0.0405 0.0403
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0041 0.0386
Loa Loa (eye worm) AUR protein kinase 0.0695 0.0478 0.0476
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.033 0.0094 0.0092
Schistosoma mansoni serine/threonine protein kinase 0.0429 0.0199 0.0508
Brugia malayi MAP kinase sur-1 0.0244 0.0005 0.0003
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0609 0.0387 0.3809
Entamoeba histolytica tyrosine kinase, putative 0.0263 0.0025 0.0189
Loa Loa (eye worm) TK/FER protein kinase 0.0498 0.0271 0.0269
Echinococcus granulosus protein kinase shaggy 0.1206 0.1013 0.1011
Entamoeba histolytica serine/threonine protein kinase, putative 0.0378 0.0145 0.119
Echinococcus granulosus retinal guanylyl cyclase 2 0.0263 0.0025 0.0023
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0334 0.0099 0.0097
Echinococcus multilocularis FL cytokine receptor 0.0263 0.0025 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Brugia malayi hypothetical protein 0.0345 0.011 0.0108
Loa Loa (eye worm) hypothetical protein 0.0345 0.011 0.0108
Trichomonas vaginalis STE family protein kinase 0.0303 0.0066 0.0615
Brugia malayi serine/threonine-protein kinase plk-2 0.0347 0.0112 0.011
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0263 0.0025 0.0189
Giardia lamblia Kinase, CAMK CAMKL 0.0422 0.0191 0.1748
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0378 0.0145 0.0141
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0476 0.0248 0.0246
Entamoeba histolytica protein kinase 2, putative 0.0326 0.009 0.0734
Echinococcus multilocularis tyrosine protein kinase Blk 0.0955 0.075 0.0748
Trichomonas vaginalis TK family protein kinase 0.0263 0.0025 0.0231
Leishmania major protein kinase A catalytic subunit 0.0814 0.0602 0.0598
Onchocerca volvulus 0.0943 0.0738 0.1025
Schistosoma mansoni tyrosine kinase 0.0456 0.0227 0.058
Schistosoma mansoni serine/threonine protein kinase 0.0301 0.0064 0.016
Entamoeba histolytica hypothetical protein 0.0266 0.0028 0.0216
Toxoplasma gondii CMGC kinase, CK2 family 0.0263 0.0024 0.0221
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0752 0.0537 0.0535
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0679 0.046 0.1183
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0814 0.0602 0.0598
Entamoeba histolytica p21-activated kinase 0.0451 0.0221 0.1828
Trichomonas vaginalis CAMK family protein kinase 0.0347 0.0112 0.1045
Schistosoma mansoni serine/threonine protein kinase 0.0654 0.0435 0.1117
Trichomonas vaginalis CK1 family protein kinase 0.0654 0.0435 0.4048
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0554 0.0329 0.0327
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0814 0.0602 0.06
Loa Loa (eye worm) hypothetical protein 0.0572 0.0349 0.0347
Echinococcus granulosus natriuretic peptide receptor 1 0.0263 0.0025 0.0023
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0245 0.0006 0.0002
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0404 0.0173 0.0171
Toxoplasma gondii hypothetical protein 0.0752 0.0537 0.529
Loa Loa (eye worm) TK/INSR protein kinase 0.1533 0.1356 0.1354
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0601 0.0379 0.0377
Schistosoma mansoni serine/threonine protein kinase 0.0683 0.0465 0.1195
Brugia malayi casein kinase I 0.0654 0.0435 0.0433
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0347 0.0112 0.011
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0695 0.0478 0.3973
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.04 0.0168 0.0166
Loa Loa (eye worm) TK protein kinase 0.0263 0.0025 0.0023
Brugia malayi Protein kinase domain containing protein 0.0785 0.0572 0.057
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Loa Loa (eye worm) hypothetical protein 0.0609 0.0387 0.0385
Brugia malayi Stress-activated protein kinase jnk-1 0.3253 0.316 0.3159
Brugia malayi Protein kinase domain containing protein 0.0498 0.0271 0.0269
Schistosoma mansoni serine/threonine protein kinase 0.0601 0.0379 0.0974
Loa Loa (eye worm) TK protein kinase 0.0263 0.0025 0.0023
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0517 0.0291 0.0289
Plasmodium falciparum protein serine/threonine kinase-1 0.1133 0.0937 0.9247
Schistosoma mansoni serine/threonine protein kinase 0.0476 0.0248 0.0635
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0295 0.0058 0.0143
Echinococcus granulosus serine threonine protein kinase nrc 0.0326 0.009 0.0088
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Loa Loa (eye worm) RhoGAP domain-containing protein 0.04 0.0168 0.0166
Brugia malayi casein kinase 1, delta 0.0654 0.0435 0.0433
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0609 0.0387 0.3809
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.1028 0.0826 0.0824
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.1154 0.0959 0.0957
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0451 0.0222 0.0218
Trichomonas vaginalis AGC family protein kinase 0.0785 0.0572 0.5328
Schistosoma mansoni hypothetical protein 0.0345 0.011 0.0279
Trichomonas vaginalis CAMK family protein kinase 0.0371 0.0137 0.1278
Echinococcus multilocularis MAM 0.0345 0.011 0.0108
Trichomonas vaginalis CAMK family protein kinase 0.0378 0.0145 0.1347
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0463 0.0234 0.0232
Trypanosoma cruzi cdc2-related kinase 3 0.0476 0.0248 0.0244
Echinococcus multilocularis tyrosine protein kinase otk 0.0295 0.0058 0.0055
Schistosoma mansoni tyrosine kinase 0.068 0.0462 0.1186
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1137 0.0941 0.0939
Trichomonas vaginalis STE family protein kinase 0.1264 0.1074 1
Leishmania major hypothetical protein, conserved 0.0263 0.0025 0.0021
Onchocerca volvulus 0.0492 0.0265 0.0345
Giardia lamblia Kinase, AGC AKT 0.1035 0.0833 0.7752
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0263 0.0025 0.0023
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0245 0.0006 0.0031
Loa Loa (eye worm) IKK protein kinase 0.6895 0.6979 0.6979
Schistosoma mansoni serine/threonine-protein kinase 0.0372 0.0138 0.0352
Entamoeba histolytica protein kinase domain containing protein 0.0377 0.0144 0.1184
Brugia malayi Protein kinase c protein 2 0.0399 0.0167 0.0165
Trichomonas vaginalis CAMK family protein kinase 0.0378 0.0145 0.1347
Entamoeba histolytica PH domain containing protein kinase, putative 0.0372 0.0138 0.1139
Onchocerca volvulus 0.0418 0.0187 0.0233
Schistosoma mansoni serine/threonine protein kinase 0.0695 0.0478 0.1228
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0263 0.0025 0.0189
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.082 0.0609 0.0607
Loa Loa (eye worm) TK/FER protein kinase 0.0263 0.0025 0.0023
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0025 0.0189
Trypanosoma brucei protein kinase, putative 0.0289 0.0051 0.0047
Entamoeba histolytica tyrosine kinase, putative 0.0263 0.0025 0.0189
Trichomonas vaginalis CAMK family protein kinase 0.0378 0.0145 0.1347
Loa Loa (eye worm) hypothetical protein 0.0295 0.0058 0.0055
Loa Loa (eye worm) hypothetical protein 0.1486 0.1307 0.1305
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0739 0.0524 0.0522
Schistosoma mansoni tyrosine kinase 0.2358 0.2221 0.573
Trichomonas vaginalis CK1 family protein kinase 0.0654 0.0435 0.4048
Plasmodium vivax calcium-dependent protein kinase, putative 0.0609 0.0387 0.3809
Loa Loa (eye worm) AGC/PKA protein kinase 0.0814 0.0602 0.06
Loa Loa (eye worm) hypothetical protein 0.1552 0.1376 0.1374
Loa Loa (eye worm) RGC/RGC protein kinase 0.0263 0.0025 0.0023
Brugia malayi Protein kinase domain containing protein 0.0389 0.0156 0.0154
Schistosoma mansoni protein kinase 0.0654 0.0435 0.1117
Trichomonas vaginalis CAMK family protein kinase 0.0391 0.0159 0.1477
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1137 0.0941 0.0939
Echinococcus granulosus glycogen synthase kinase 3 beta 0.1206 0.1013 0.1011
Brugia malayi Protein kinase domain containing protein 0.0463 0.0234 0.0232
Brugia malayi Protein kinase domain containing protein 0.1383 0.1199 0.1197
Plasmodium falciparum protein kinase, putative 0.0451 0.0222 0.2175
Echinococcus granulosus casein kinase I delta 0.0654 0.0435 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0654 0.0435 0.0433
Schistosoma mansoni serine/threonine kinase 0.0507 0.028 0.0718
Brugia malayi Immunoglobulin I-set domain containing protein 0.0418 0.0187 0.0185
Brugia malayi Protein kinase domain containing protein 0.0498 0.0271 0.0269
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1206 0.1013 0.1011
Brugia malayi Peroxidasin 0.0298 0.0061 0.0059
Entamoeba histolytica protein kinase, putative 0.0404 0.0173 0.1424
Echinococcus multilocularis cyclin dependent kinase 7 0.0618 0.0396 0.0394
Plasmodium vivax tyrosine kinase-like protein, putative 0.0263 0.0025 0.0229
Entamoeba histolytica serine/threonine kinase, putative 0.0263 0.0025 0.0189
Entamoeba histolytica cell division protein kinase 2, putative 0.0476 0.0248 0.2053
Trypanosoma cruzi casein kinase II, putative 0.0263 0.0024 0.002
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1719 0.1551 0.1549
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0814 0.0602 0.06
Plasmodium vivax protein kinase Crk2 0.0476 0.0248 0.2434
Schistosoma mansoni protein kinase 0.0263 0.0025 0.0058
Schistosoma mansoni serine/threonine protein kinase 0.1803 0.1639 0.4227
Echinococcus multilocularis 0.0993 0.079 0.0788
Entamoeba histolytica receptor protein kinase, putative 0.0263 0.0025 0.0189
Brugia malayi Protein kinase domain containing protein 0.082 0.0609 0.0607
Loa Loa (eye worm) hypothetical protein 0.0263 0.0025 0.0023
Echinococcus multilocularis serine threonine protein kinase 0.0647 0.0427 0.0425
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.1264 0.1074 0.107
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0451 0.0222 0.022
Entamoeba histolytica hypothetical protein 0.0263 0.0025 0.0189
Trichomonas vaginalis STE family protein kinase 0.0404 0.0173 0.1607
Loa Loa (eye worm) TK protein kinase 0.0263 0.0025 0.0023
Entamoeba histolytica tyrosine kinase, putative 0.0263 0.0025 0.0189
Loa Loa (eye worm) TK/FER protein kinase 0.0498 0.0271 0.0269
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0025 0.0189
Trichomonas vaginalis CAMK family protein kinase 0.0347 0.0112 0.1045
Echinococcus multilocularis roundabout 2 0.033 0.0094 0.0092
Entamoeba histolytica protein kinase domain containing protein 0.1206 0.1013 0.8447
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0025 0.0189
Schistosoma mansoni serine/threonine protein kinase 0.1931 0.1773 0.4574
Schistosoma mansoni serine/threonine protein kinase 0.0638 0.0417 0.1073
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Trichomonas vaginalis CMGC family protein kinase 0.1133 0.0937 0.8726
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0334 0.0099 0.0097
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0301 0.0064 0.0062
Entamoeba histolytica PH domain containing protein kinase, putative 0.086 0.0651 0.5417
Trichomonas vaginalis AGC family protein kinase 0.0263 0.0025 0.0231
Onchocerca volvulus 0.2677 0.2556 0.364
Loa Loa (eye worm) RGC/RGC protein kinase 0.0263 0.0025 0.0023
Schistosoma mansoni tyrosine kinase 0.0702 0.0485 0.1248
Schistosoma mansoni serine/threonine protein kinase 0.0618 0.0396 0.1018
Entamoeba histolytica protein kinase, putative 0.0263 0.0025 0.0189
Trichomonas vaginalis AGC family protein kinase 0.0695 0.0478 0.4449
Echinococcus granulosus activin receptor type 0.4152 0.4103 0.4102
Brugia malayi Serine/threonine-protein kinase Pim-3 0.233 0.2192 0.219
Entamoeba histolytica protein kinase, putative 0.0263 0.0025 0.0189
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.1982 0.1827 0.1825
Schistosoma mansoni tyrosine kinase 0.1533 0.1356 0.3497
Schistosoma mansoni serine/threonine protein kinase 0.1154 0.0959 0.2471
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0263 0.0025 0.0231
Brugia malayi Protein kinase domain containing protein 0.0263 0.0025 0.0023
Brugia malayi Immunoglobulin I-set domain containing protein 0.1681 0.1511 0.151
Echinococcus granulosus dual specificity protein kinase clk2 0.1133 0.0937 0.0935
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.1028 0.0826 0.0824
Echinococcus granulosus cyclin dependent kinase 7 0.0618 0.0396 0.0394
Echinococcus multilocularis c Jun NH2 terminal kinase 0.3253 0.316 0.3159
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0244 0.0005 0.0003
Schistosoma mansoni tyrosine kinase 0.0966 0.0761 0.1961
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.04 0.0168 0.0166
Entamoeba histolytica protein kinase, putative 0.0306 0.0069 0.0562
Brugia malayi Casein kinase II, alpha chain 0.0263 0.0024 0.0022
Loa Loa (eye worm) TK/FER protein kinase 0.0498 0.0271 0.0269
Echinococcus granulosus cGMP dependent protein kinase 1 0.0301 0.0064 0.0062
Brugia malayi SRC-1 0.1137 0.0941 0.0939
Trypanosoma cruzi cdc2-related kinase 1 0.0476 0.0248 0.0244
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.1264 0.1074 0.107
Brugia malayi Protein kinase domain containing protein 0.0263 0.0025 0.0023
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0025 0.0189
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0295 0.0058 0.0047
Brugia malayi Protein kinase domain containing protein 0.0903 0.0696 0.0694
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.206 0.1908 0.1907
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0601 0.0379 0.0377
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0263 0.0025 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0609 0.0387 0.0994
Trichomonas vaginalis CAMK family protein kinase 0.0263 0.0025 0.0231
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0814 0.0602 0.0598
Echinococcus multilocularis cyclin dependent kinase 0.0476 0.0248 0.0246
Entamoeba histolytica hypothetical protein 0.0263 0.0025 0.0189
Echinococcus granulosus aurora kinase A 0.0695 0.0478 0.0476
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1137 0.0941 0.0939
Schistosoma mansoni serine/threonine protein kinase 0.1133 0.0937 0.2415
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0306 0.0069 0.0067
Echinococcus multilocularis twitchin 0.0383 0.015 0.0148
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0025 0.0189
Schistosoma mansoni protein kinase 0.174 0.1573 0.4057
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0601 0.0379 0.0377
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0476 0.0248 0.0246
Schistosoma mansoni roundabout 0.0295 0.0058 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0263 0.0025 0.0231
Echinococcus multilocularis protein kinase shaggy 0.1206 0.1013 0.1011
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0799 0.0587 0.0585
Trichomonas vaginalis AGC family protein kinase 0.0601 0.0379 0.3531
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0601 0.0379 0.0377
Brugia malayi Immunoglobulin I-set domain containing protein 0.0295 0.0058 0.0055
Schistosoma mansoni tyrosine kinase 0.068 0.0462 0.1186
Schistosoma mansoni serine/threonine protein kinase 0.068 0.0461 0.1186
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0282 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0295 0.0058 0.0055
Echinococcus multilocularis G protein coupled receptor kinase 6 0.1487 0.1308 0.1306
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0326 0.009 0.0088
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0814 0.0602 0.0598
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0303 0.0066 0.0638
Trypanosoma cruzi polo-like protein kinase, putative 0.0347 0.0112 0.0108
Echinococcus granulosus tyrosine protein kinase Src64B 0.1137 0.0941 0.0939
Brugia malayi Protein kinase domain containing protein 0.2677 0.2556 0.2555
Trypanosoma cruzi protein kinase, putative 0.0263 0.0025 0.0021
Loa Loa (eye worm) hypothetical protein 0.0679 0.046 0.0458
Loa Loa (eye worm) hypothetical protein 0.0295 0.0058 0.0055
Schistosoma mansoni tyrosine kinase 0.0966 0.0761 0.1961
Entamoeba histolytica tyrosine kinase, putative 0.0263 0.0025 0.0189
Loa Loa (eye worm) RGC/RGC protein kinase 0.0263 0.0025 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0463 0.0234 0.2176
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0263 0.0025 0.0021
Schistosoma mansoni septate junction protein 0.0295 0.0058 0.0143
Echinococcus granulosus dual specificity 0.0306 0.0069 0.0067
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0609 0.0387 0.0383
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.1028 0.0826 0.0824
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1487 0.1308 0.1306
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.04 0.0168 0.0429
Schistosoma mansoni tyrosine kinase 0.0263 0.0025 0.0058
Schistosoma mansoni tyrosine kinase 0.1121 0.0924 0.238
Schistosoma mansoni serine/threonine protein kinase 0.0769 0.0555 0.1427
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0301 0.0064 0.062
Schistosoma mansoni serine/threonine protein kinase 0.0377 0.0144 0.0366
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0263 0.0024 0.0221
Trypanosoma brucei Flagellum attachment zone protein 20 0.0263 0.0025 0.0021
Echinococcus granulosus TGF-beta receptor type-1 0.0912 0.0705 0.0703
Giardia lamblia Kinase, CMGC CLK 0.1133 0.0937 0.8722
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0245 0.0006 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.0306 0.0069 0.0646
Schistosoma mansoni titin 0.0418 0.0187 0.0478
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0279 0.0041 0.0039
Schistosoma mansoni titin 0.0295 0.0058 0.0143
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.233 0.2192 0.219
Echinococcus granulosus tyrosine kinase 0.0498 0.0271 0.0269
Echinococcus multilocularis tyrosine protein kinase csk 0.0263 0.0025 0.0023
Echinococcus granulosus serine:threonine protein kinase mig 15 0.1552 0.1376 0.1374
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.1133 0.0937 0.0933
Trypanosoma cruzi protein kinase, putative 0.0263 0.0025 0.0021
Echinococcus granulosus cGMP dependent protein kinase 1 0.0301 0.0064 0.0062
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0263 0.0025 0.0023
Entamoeba histolytica serine/threonine kinase, putative 0.0263 0.0025 0.0189
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Schistosoma mansoni tyrosine kinase 0.0263 0.0025 0.0058
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0306 0.0069 0.0067
Entamoeba histolytica casein kinase, putative 0.0654 0.0435 0.3613
Schistosoma mansoni serine/threonine protein kinase 0.0813 0.0601 0.1546
Schistosoma mansoni cell adhesion molecule 0.0295 0.0058 0.0143
Brugia malayi EGF-like domain containing protein 0.0277 0.0039 0.0037
Trichomonas vaginalis CMGC family protein kinase 0.0306 0.0069 0.0646
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0286 0.0049 0.0046
Schistosoma mansoni cell adhesion molecule 0.033 0.0094 0.0238
Entamoeba histolytica tyrosine kinase, putative 0.0263 0.0025 0.0189
Schistosoma mansoni protein kinase 0.0263 0.0025 0.0058
Brugia malayi protein unc-22 0.0418 0.0187 0.0185
Entamoeba histolytica tyrosine kinase, putative 0.0263 0.0025 0.0189
Entamoeba histolytica protein kinase, putative 0.0721 0.0504 0.4196
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.1133 0.0937 0.0933
Entamoeba histolytica PH domain containing protein kinase, putative 0.086 0.0651 0.5417
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.1137 0.0941 0.0939
Loa Loa (eye worm) hypothetical protein 0.0371 0.0137 0.0135
Loa Loa (eye worm) TK/FER protein kinase 0.0263 0.0025 0.0023
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.1137 0.0941 0.0939
Plasmodium falciparum protein kinase, putative 0.0263 0.0025 0.0229
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0453 0.0223 0.0221
Echinococcus multilocularis protein kinase 0.0263 0.0025 0.0023
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0347 0.0112 0.011
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0377 0.0144 0.0142
Trichomonas vaginalis CAMK family protein kinase 0.0378 0.0145 0.1347
Loa Loa (eye worm) hypothetical protein 0.175 0.1583 0.1582
Entamoeba histolytica cell division protein kinase 2, putative 0.052 0.0294 0.244
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Loa Loa (eye worm) TK protein kinase 0.1681 0.1511 0.151
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0263 0.0025 0.0023
Plasmodium vivax serine/threonine protein kinase, putative 0.0244 0.0004 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0378 0.0145 0.1347
Onchocerca volvulus Serine\/threonine kinase homolog 0.0347 0.0112 0.0126
Entamoeba histolytica protein kinase, putative 0.0739 0.0524 0.4358
Loa Loa (eye worm) RGC/RGC protein kinase 0.0263 0.0025 0.0023
Loa Loa (eye worm) TK/EPH protein kinase 0.0354 0.012 0.0118
Trypanosoma brucei Pseudokinase, putative 0.0263 0.0025 0.0021
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus multilocularis casein kinase i 0.0654 0.0435 0.0433
Trypanosoma cruzi aurora B kinase, putative 0.0695 0.0478 0.0474
Trichomonas vaginalis protein kinase atn1, putative 0.0263 0.0025 0.0231
Echinococcus multilocularis dual specificity mitogen activated protein 0.1264 0.1074 0.1072
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus granulosus casein kinase I alpha 0.0654 0.0435 0.0433
Loa Loa (eye worm) hypothetical protein 0.0747 0.0531 0.0529
Brugia malayi Receptor family ligand binding region containing protein 0.0263 0.0025 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Onchocerca volvulus Serine\/threonine kinase homolog 0.0334 0.0099 0.0106
Brugia malayi serine/threonine kinase 12 0.0695 0.0478 0.0476
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0326 0.009 0.0874
Entamoeba histolytica tyrosine kinase, putative 0.0263 0.0025 0.0189
Loa Loa (eye worm) TK/FER protein kinase 0.0498 0.0271 0.0269
Brugia malayi Variant SH3 domain containing protein 0.0282 0.0044 0.0042
Brugia malayi serine/threonine-protein kinase PAK 7 0.2252 0.211 0.2109
Brugia malayi Protein kinase domain containing protein 0.1719 0.1551 0.1549
Trichomonas vaginalis conserved hypothetical protein 0.0263 0.0025 0.0231
Brugia malayi Protein kinase domain containing protein 0.0244 0.0004 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0814 0.0602 0.0598
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0263 0.0025 0.0023
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.1133 0.0937 0.9247
Schistosoma mansoni protein kinase 0.0404 0.0173 0.044
Entamoeba histolytica hypothetical protein 0.0263 0.0025 0.0189
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Plasmodium vivax protein kinase, putative 0.028 0.0042 0.0404
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.1383 0.1199 0.1196
Trypanosoma brucei SNF1-related protein kinases, putative 0.0378 0.0145 0.0141
Giardia lamblia Kinase, NEK 0.0303 0.0066 0.058
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0263 0.0025 0.0229
Trichomonas vaginalis CMGC family protein kinase 0.0263 0.0024 0.0223
Plasmodium falciparum NIMA related kinase 1 0.0303 0.0066 0.0638
Brugia malayi Protein kinase domain containing protein 0.0263 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0747 0.0531 0.0529
Echinococcus multilocularis mitogen activated protein kinase 3 0.0244 0.0005 0.0003
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0301 0.0064 0.0062
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus multilocularis kinase suppressor of Ras 1 0.0263 0.0025 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0266 0.0027 0.0251
Echinococcus granulosus tyrosine protein kinase Fyn 0.1137 0.0941 0.0939
Schistosoma mansoni tyrosine kinase 0.3934 0.3874 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0263 0.0025 0.0229
Brugia malayi probable protein kinase 0.174 0.1573 0.1571
Giardia lamblia Kinase, STE STE20 0.0404 0.0173 0.1576
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0422 0.0191 0.1872
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0747 0.0531 0.0528
Loa Loa (eye worm) hypothetical protein 0.0714 0.0497 0.0495
Loa Loa (eye worm) hypothetical protein 0.082 0.0609 0.0607
Echinococcus granulosus tyrosine protein kinase shark 0.0736 0.0521 0.0519
Brugia malayi hypothetical protein 0.0714 0.0497 0.0495
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0371 0.0137 0.0135
Brugia malayi Protein kinase domain containing protein 0.0263 0.0025 0.0023
Echinococcus multilocularis integrin linked protein kinase 0.0263 0.0025 0.0023
Trypanosoma brucei protein kinase, putative 0.0451 0.0222 0.0218
Loa Loa (eye worm) TK/FER protein kinase 0.0263 0.0025 0.0023
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0378 0.0145 0.0141
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0326 0.009 0.0874
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0263 0.0025 0.0189
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0025 0.0189
Toxoplasma gondii STE kinase 0.0263 0.0025 0.0229
Echinococcus multilocularis calcium dependent protein kinase 0.0421 0.019 0.0188
Loa Loa (eye worm) TK/ROR protein kinase 0.0459 0.023 0.0228
Echinococcus granulosus Vam6:Vps39 protein 0.0747 0.0531 0.0529
Brugia malayi Protein kinase domain containing protein 0.0498 0.0271 0.0269
Trichomonas vaginalis STE family protein kinase 0.0263 0.0025 0.0231
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1631 0.1459 0.1457
Echinococcus multilocularis calcium activated potassium channel 0.0371 0.0138 0.0135
Plasmodium vivax serine/threonine kinase-1, putative 0.1133 0.0937 0.9247
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.033 0.0094 0.0092
Schistosoma mansoni tyrosine kinase 0.0702 0.0485 0.1248
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0609 0.0387 0.0385
Brugia malayi Variant SH3 domain containing protein 0.0417 0.0185 0.0183
Entamoeba histolytica protein kinase, putative 0.061 0.0388 0.3227
Echinococcus multilocularis epidermal growth factor receptor 0.0966 0.0761 0.0759
Trichomonas vaginalis AGC family protein kinase 0.0303 0.0066 0.0615
Schistosoma mansoni serine/threonine protein kinase 0.0813 0.0601 0.1546
Trichomonas vaginalis CMGC family protein kinase 0.0306 0.0069 0.0646
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0618 0.0396 0.0394
Brugia malayi Fibronectin type III domain containing protein 0.0714 0.0497 0.0495
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.1487 0.1308 0.1306
Echinococcus granulosus fibroblast growth factor receptor 4 0.1485 0.1306 0.1304
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0747 0.0531 0.0529
Leishmania major protein kinase, putative 0.1133 0.0937 0.0933
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.1803 0.1639 0.1637
Brugia malayi serine/threonine-protein kinase 6 0.0695 0.0478 0.0476
Leishmania major protein kinase, putative 0.0695 0.0478 0.0474
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.2591 0.2466 0.2464
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.1264 0.1074 0.1072
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0814 0.0602 0.06
Echinococcus multilocularis heat shock protein 70 0.0263 0.0025 0.0023
Leishmania major protein kinase, putative 0.1133 0.0937 0.0933
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.1133 0.0937 0.0933
Onchocerca volvulus Slit protein homolog 0.0277 0.0039 0.002
Plasmodium falciparum calcium-dependent protein kinase 3 0.0609 0.0387 0.3809
Loa Loa (eye worm) TK/CSK protein kinase 0.0263 0.0025 0.0023
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0319 0.0083 0.0081
Entamoeba histolytica protein kinase, putative 0.0263 0.0025 0.0189
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0375 0.0142 0.014
Echinococcus multilocularis casein kinase I alpha 0.0654 0.0435 0.0433
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0295 0.0058 0.0055
Giardia lamblia Kinase, STE STE20 0.0245 0.0006 0.0017
Trypanosoma brucei casein kinase I, isoform 2 0.0654 0.0435 0.0431
Echinococcus multilocularis lachesin 0.0295 0.0058 0.0055
Echinococcus granulosus serine:threonine protein kinase TAO1 0.2935 0.2827 0.2825
Entamoeba histolytica protein kinase, putative 0.0426 0.0196 0.1616
Echinococcus multilocularis tyrosine kinase 0.0263 0.0025 0.0023
Brugia malayi Immunoglobulin I-set domain containing protein 0.033 0.0094 0.0092
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0993 0.079 0.0788
Echinococcus multilocularis expressed protein 0.0244 0.0004 0.0002
Echinococcus granulosus tyrosine protein kinase Src42A 0.0708 0.0491 0.0489
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0295 0.0058 0.0055
Trichomonas vaginalis protein tyrosine kinase, putative 0.0263 0.0025 0.0231
Entamoeba histolytica protein kinase, putative 0.038 0.0147 0.1212
Schistosoma mansoni serine/threonine protein kinase 0.0371 0.0138 0.035
Echinococcus granulosus receptor type guanylyl cyclase 0.0263 0.0025 0.0023
Echinococcus multilocularis expressed conserved protein 0.0301 0.0064 0.0062
Brugia malayi Protein kinase domain containing protein 0.0375 0.0142 0.014
Giardia lamblia Kinase, AGC PKA 0.0326 0.009 0.0804
Entamoeba histolytica protein kinase, putative 0.1206 0.1013 0.8447
Entamoeba histolytica hypothetical protein, conserved 0.0263 0.0025 0.0189
Trichomonas vaginalis CMGC family protein kinase 0.0244 0.0005 0.0044
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0263 0.0025 0.0023
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0263 0.0025 0.0023
Schistosoma mansoni adapter molecule crk 0.0417 0.0185 0.0473
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0244 0.0005 0.0001
Echinococcus multilocularis 0.0257 0.0018 0.0016
Echinococcus multilocularis tyrosine kinase 0.0498 0.0271 0.0269
Echinococcus multilocularis natriuretic peptide receptor 1 0.0263 0.0025 0.0023
Loa Loa (eye worm) CAMK/PIM protein kinase 0.233 0.2192 0.219
Brugia malayi cell division control protein 2 homolog 0.0476 0.0248 0.0246
Schistosoma mansoni serine/threonine protein kinase 0.0375 0.0142 0.036
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0966 0.0761 0.0759
Echinococcus multilocularis Immunoglobulin 0.0679 0.046 0.0458
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0306 0.0069 0.0065
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0263 0.0025 0.0189
Plasmodium falciparum casein kinase 1 0.0654 0.0435 0.4281
Brugia malayi Protein kinase domain containing protein 0.0486 0.0258 0.0256
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1568 0.1393 0.1391
Brugia malayi Protein kinase domain containing protein 0.0263 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0263 0.0025 0.0023
Loa Loa (eye worm) CAMK protein kinase 0.0418 0.0187 0.0185
Echinococcus granulosus cyclin dependent kinase 19 0.1803 0.1639 0.1637
Entamoeba histolytica serine/threonine protein kinase, putative 0.0347 0.0112 0.092
Schistosoma mansoni protein kinase 0.2677 0.2556 0.6596
Toxoplasma gondii histone kinase SNF1, putative 0.0378 0.0145 0.1414
Entamoeba histolytica casein kinase, putative 0.0263 0.0024 0.0182
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0378 0.0145 0.0141
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0377 0.0144 0.0142
Trypanosoma cruzi cdc2-related kinase 3 0.0476 0.0248 0.0244
Loa Loa (eye worm) hypothetical protein 0.0714 0.0497 0.0495
Echinococcus multilocularis c src tyrosine kinase 0.068 0.0462 0.046
Echinococcus multilocularis protein tyrosine kinase 0.3934 0.3874 0.3873
Loa Loa (eye worm) protein kinase domain-containing protein 0.0389 0.0156 0.0154
Schistosoma mansoni serine/threonine protein kinase 0.1383 0.1199 0.3091
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.1131 0.0934 0.0933
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Trichomonas vaginalis CMGC family protein kinase 0.0306 0.0069 0.0646
Loa Loa (eye worm) hypothetical protein 0.0682 0.0463 0.0461
Brugia malayi hypothetical protein 0.2935 0.2827 0.2825
Echinococcus granulosus tyrosine kinase 0.0955 0.075 0.0748
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.1264 0.1074 0.107
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0025 0.0189
Echinococcus granulosus tyrosine protein kinase otk 0.0295 0.0058 0.0055
Schistosoma mansoni serine/threonine protein kinase 0.0371 0.0138 0.035
Toxoplasma gondii AGC kinase 0.0814 0.0602 0.5936
Loa Loa (eye worm) TK/FER protein kinase 0.0263 0.0025 0.0023
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0263 0.0025 0.0058
Toxoplasma gondii AGC kinase 0.0814 0.0602 0.5936
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0263 0.0025 0.0058
Trichomonas vaginalis CMGC family protein kinase 0.0263 0.0024 0.0223
Trichomonas vaginalis TKL family protein kinase 0.0263 0.0025 0.0231
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0263 0.0025 0.0231
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0679 0.046 0.1183
Trichomonas vaginalis AGC family protein kinase 0.0242 0.0002 0.002
Echinococcus multilocularis casein kinase I alpha 0.0654 0.0435 0.0433
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0244 0.0005 0.0001
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0955 0.075 0.0748
Trichomonas vaginalis AGC family protein kinase 0.0695 0.0478 0.4449
Schistosoma mansoni protein kinase 0.038 0.0147 0.0375
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0609 0.0387 0.0385
Echinococcus multilocularis PAK box P21 Rho binding 0.038 0.0147 0.0145
Entamoeba histolytica protein kinase domain containing protein 0.1206 0.1013 0.8447
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0654 0.0435 0.0431
Loa Loa (eye worm) TK/ABL protein kinase 0.2592 0.2467 0.2465
Echinococcus granulosus NDR protein kinase 0.0601 0.0379 0.0377
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0263 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0931 0.0725 0.0723

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) 12 uM PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4716 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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