Detailed information for compound 1403649

Basic information

Technical information
  • TDR Targets ID: 1403649
  • Name: 3-dimethylamino-1-[3-(trifluoromethyl)phenyl] thiourea
  • MW: 263.283 | Formula: C10H12F3N3S
  • H donors: 1 H acceptors: 0 LogP: 3.3 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(N=C(Nc1cccc(c1)C(F)(F)F)S)C
  • InChi: 1S/C10H12F3N3S/c1-16(2)15-9(17)14-8-5-3-4-7(6-8)10(11,12)13/h3-6H,1-2H3,(H2,14,15,17)
  • InChiKey: OJYFWMRPMRXROS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4776-26-5
  • STK097221
  • ZINC00098281
  • MLS000861707
  • N1-[3-(trifluoromethyl)phenyl]-2,2-dimethylhydrazine-1-carbothioamide
  • SMR000460491

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0058 0.018
Schistosoma mansoni hypothetical protein 0.0593 0.4195 0.4192
Echinococcus multilocularis JmjC domain containing protein 4 0.0035 0.0143 0.0137
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0069 0.0393 0.0388
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0077
Onchocerca volvulus Chorion peroxidase homolog 0.0221 0.1497 0.5074
Schistosoma mansoni notch 0.0034 0.0135 0.0129
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0152 0.0519
Loa Loa (eye worm) MH2 domain-containing protein 0.0232 0.1576 0.5391
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.0052 0.0155
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0058 0.0668
Trypanosoma brucei protein kinase, putative 0.0054 0.0281 0.0944
Echinococcus multilocularis lysine specific demethylase 5A 0.013 0.0835 0.083
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0057 0.0302 0.0297
Schistosoma mansoni slit 0.0034 0.0135 0.0129
Leishmania major eukaryotic initiation factor 4a, putative 0.0417 0.2918 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0052 0.0177
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0143 0.0489
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0322 0.1082
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0035 0.0143 0.0468
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0652 0.2217
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0188 0.0627
Loa Loa (eye worm) jmjC domain-containing protein 0.0117 0.074 0.2523
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0016 0.0032
Schistosoma mansoni hypothetical protein 0.0034 0.0135 0.0129
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0058 0.0199
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0059 0.0322 0.0316
Onchocerca volvulus Alhambra homolog 0.0057 0.0302 0.0931
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0281 0.0965
Schistosoma mansoni cpg binding protein 0.0066 0.0369 0.0364
Echinococcus granulosus neurogenic locus notch protein 4 0.0034 0.0135 0.0129
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0059 0.0322 0.1082
Echinococcus granulosus neuropeptide s receptor 0.045 0.3154 0.315
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0026 0.0081 0.0256
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0281 0.0944
Brugia malayi Cytochrome P450 family protein 0.0041 0.0188 0.0627
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0417 0.2918 1
Loa Loa (eye worm) doublecortin family protein 0.002 0.0034 0.0096
Schistosoma mansoni rab6-interacting 0.002 0.0034 0.0028
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0126 0.043
Loa Loa (eye worm) PHD-finger family protein 0.0057 0.0302 0.1019
Loa Loa (eye worm) hypothetical protein 0.0084 0.0502 0.1706
Brugia malayi notch-like transmembrane receptor 0.0034 0.0135 0.0443
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0152 0.0498
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0126 0.012
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0417 0.0412
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0125 0.0795 0.079
Brugia malayi Pax transcription factor protein 2 0.0259 0.1768 0.6053
Onchocerca volvulus Peroxidase homolog 0.0221 0.1497 0.5074
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0042 0.0195 0.0189
Brugia malayi mbt repeat family protein 0.0096 0.059 0.2005
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0302 0.1016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0007 0.0022
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0322 0.1082
Brugia malayi Animal haem peroxidase family protein 0.0221 0.1497 0.5122
Schistosoma mansoni hypothetical protein 0.0034 0.0135 0.0129
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0417 0.2918 0.2914
Echinococcus multilocularis neuropeptide s receptor 0.045 0.3154 0.315
Loa Loa (eye worm) hypothetical protein 0.0221 0.1497 0.5122
Echinococcus granulosus RUN 0.002 0.0034 0.0028
Brugia malayi N-terminal motif family protein 0.0176 0.1165 0.398
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0052 0.0155
Loa Loa (eye worm) hypothetical protein 0.0221 0.1497 0.5122
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0084 0.0502 0.1706
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0035
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0123 0.078 0.2658
Loa Loa (eye worm) matrix metalloproteinase 0.0069 0.0393 0.133
Echinococcus granulosus fibropellin Ia 0.0034 0.0135 0.0129
Plasmodium falciparum glutathione reductase 0.0046 0.0225 0.0749
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0322 0.1082
Onchocerca volvulus 0.0259 0.1768 0.6014
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0322 0.1082
Trypanosoma brucei trypanothione reductase 0.0046 0.0225 0.0749
Loa Loa (eye worm) MBCTL1 0.011 0.0686 0.2337
Schistosoma mansoni phosphatidylserine receptor 0.0035 0.0143 0.0137
Brugia malayi jmjC domain containing protein 0.0137 0.0888 0.3029
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0387 0.2701 0.2697
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.017 0.0582
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0281 0.0944
Schistosoma mansoni single-minded 0.0056 0.0297 0.0292
Echinococcus multilocularis geminin 0.0507 0.3569 0.3565
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0034 0.0028
Loa Loa (eye worm) hypothetical protein 0.0036 0.015 0.0496
Loa Loa (eye worm) hypothetical protein 0.0221 0.1497 0.5122
Echinococcus multilocularis slit 2 protein 0.0034 0.0135 0.0129
Schistosoma mansoni laminin gamma-3 chain 0.0034 0.0135 0.0129
Onchocerca volvulus Peroxidase homolog 0.0221 0.1497 0.5074
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.0052 0.0155
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0025 0.0065
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0028 0.0278
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0417 0.2918 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0059 0.0322 0.1082
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0152 0.0498
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0059 0.0322 0.1082
Loa Loa (eye worm) hypothetical protein 0.0069 0.0393 0.133
Plasmodium vivax glutathione reductase, putative 0.0046 0.0225 0.0749
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0126 0.012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0023 0.0017
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Schistosoma mansoni cell polarity protein 0.0034 0.0135 0.0129
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0281 0.0944
Echinococcus granulosus lysine specific demethylase 5A 0.0137 0.0888 0.0883
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0417 0.2918 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0291 0.0285
Brugia malayi jmjC domain containing protein 0.0247 0.1685 0.5766
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0126 0.0409
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0417 0.2918 0.2914
Brugia malayi EGF-like domain containing protein 0.0034 0.0135 0.0443
Loa Loa (eye worm) matrixin family protein 0.0154 0.1005 0.343
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0058 0.018
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.078 1
Loa Loa (eye worm) inositol-1 0.0036 0.0152 0.0501
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.017 0.0164
Trypanosoma brucei cytochrome P450, putative 0.0041 0.0188 0.0624
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0022 0.0052 0.0583
Plasmodium falciparum thioredoxin reductase 0.0046 0.0225 0.0749
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0058 0.018
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0058 0.0425
Trypanosoma cruzi ISWI complex protein 0.0031 0.0115 0.0394
Toxoplasma gondii hypothetical protein 0.0019 0.0028 0.0074
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0058 0.0177
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0126 0.0409
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0049 0.0245 0.024
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0126 0.043
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0322 0.1082
Trypanosoma brucei ISWI complex protein 0.0031 0.0115 0.0373
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0322 0.1082
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0052 0.0177
Brugia malayi jmjC domain containing protein 0.0035 0.0143 0.0471
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0022 0.0051 0.0154
Loa Loa (eye worm) hypothetical protein 0.0035 0.0143 0.0471
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0143 0.0471
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0269 0.09
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0281 0.0276
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.017 0.0561
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.015 0.0144
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0028 0.0278
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0123 0.078 0.2674
Schistosoma mansoni bromodomain containing protein 0.0131 0.0842 0.0837
Brugia malayi hypothetical protein 0.0188 0.1254 0.4285
Loa Loa (eye worm) hypothetical protein 0.0221 0.1497 0.5122
Brugia malayi F/Y-rich N-terminus family protein 0.004 0.0184 0.0611
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0058 0.0177
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0247 0.1685 0.168
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0417 0.2918 1
Echinococcus multilocularis protein jagged 1 0.0034 0.0135 0.0129
Echinococcus granulosus protein jagged 2 0.0034 0.0135 0.0129
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.0052 0.0155
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0322 0.1082
Echinococcus granulosus delta-like protein 1 0.0034 0.0135 0.0129
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0007 0.0022
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.015 0.0144
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0022 0.0052 0.0583
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0035 0.0143 0.0137
Echinococcus multilocularis lysine specific demethylase 6a 0.0035 0.0143 0.0137
Brugia malayi Blistered cuticle protein 3 0.0221 0.1497 0.5122
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.0052 0.0155
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0126 0.012
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.0052 0.0155
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0737 0.2509
Echinococcus granulosus neuropeptide receptor A26 0.045 0.3154 0.315
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0052 0.0155
Schistosoma mansoni hypothetical protein 0.0034 0.0135 0.0129
Schistosoma mansoni hypothetical protein 0.0507 0.3569 0.3565
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0322 0.1082
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Giardia lamblia High cysteine protein 0.0034 0.0135 0.044
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0028 0.0074
Echinococcus granulosus dnaJ subfamily B 0.0409 0.2854 0.285
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0025 0.0065
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.004 0.0184 0.0611
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0123 0.078 0.0775
Brugia malayi Inositol-1 0.0036 0.0152 0.0501
Echinococcus multilocularis peroxidasin 0.0221 0.1497 0.1493
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.0052 0.0155
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.0052 0.0155
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0152 0.0498
Loa Loa (eye worm) hypothetical protein 0.0221 0.1497 0.5122
Echinococcus granulosus neurogenic locus notch protein 0.0034 0.0135 0.0129
Schistosoma mansoni phd/f-box containing protein 0.0035 0.0143 0.0137
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0225 0.0219
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0164 0.1083 0.1078
Loa Loa (eye worm) jmjC domain-containing protein 0.0137 0.0888 0.3029
Toxoplasma gondii hypothetical protein 0.0052 0.0269 0.09
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0417 0.2918 1
Onchocerca volvulus 0.0034 0.0135 0.035
Loa Loa (eye worm) animal heme peroxidase 0.0221 0.1497 0.5122
Echinococcus granulosus jumonji domain containing protein 0.0079 0.0463 0.0458
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0417 0.2918 0.2914
Leishmania major protein kinase, putative 0.0019 0.0028 0.0094
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.0052 0.0155
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0022 0.0052 0.0583
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0152 0.0498
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.017 0.0564
Schistosoma mansoni hypothetical protein 0.0042 0.0193 0.0188
Brugia malayi isocitrate dehydrogenase 0.0032 0.0126 0.0412
Echinococcus multilocularis fat cadherin tumor suppressor 0.0034 0.0135 0.0129
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.0052 0.0155
Toxoplasma gondii GAF domain-containing protein 0.0019 0.0028 0.0074
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0026 0.0081 0.0259
Schistosoma mansoni notch 0.0034 0.0135 0.0129
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0126 0.0412
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0059 0.0322 0.1102
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0007 0.0022
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0417 0.2918 0.2914
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0417 0.2918 1
Loa Loa (eye worm) hypothetical protein 0.0221 0.1497 0.5122
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0269 0.09
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0022 0.0052 0.0583
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0049 0.0245 0.024
Echinococcus granulosus lysine specific demethylase 6a 0.0035 0.0143 0.0137
Echinococcus granulosus neurogenic locus notch protein 0.0034 0.0135 0.0129
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0034 0.0028
Brugia malayi Hemopexin family protein 0.0098 0.0603 0.205
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.0052 0.0155
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0126 0.012
Plasmodium falciparum eukaryotic initiation factor 4A 0.0417 0.2918 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.0052 0.0155
Brugia malayi PHD-finger family protein 0.0054 0.028 0.0942
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0152 0.1874
Onchocerca volvulus Peroxidasin homolog 0.0221 0.1497 0.5074
Echinococcus multilocularis RUN 0.002 0.0034 0.0028
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0058 0.0668
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0007 0.0022
Toxoplasma gondii EGF family domain-containing protein 0.0034 0.0135 0.044
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0322 0.1082
Brugia malayi Muscle positioning protein 4 0.0034 0.0135 0.0443
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.017 0.0561
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0022 0.0052 0.0583
Onchocerca volvulus 0.0059 0.0317 0.0982
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0652 0.8802
Loa Loa (eye worm) hypothetical protein 0.0221 0.1497 0.5122
Brugia malayi Cadherin domain containing protein 0.0034 0.0135 0.0443
Onchocerca volvulus Putative cubilin 0.0034 0.0135 0.035
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0059 0.0322 0.1082
Loa Loa (eye worm) hypothetical protein 0.0035 0.0143 0.0471
Brugia malayi mbt repeat family protein 0.0096 0.059 0.2005
Loa Loa (eye worm) blistered cuticle protein 3 0.0221 0.1497 0.5122
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.017 0.0561
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.017 0.0561
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0417 0.2918 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0281 0.0965
Schistosoma mansoni peroxidasin 0.0221 0.1497 0.1493
Plasmodium vivax RNA helicase-1, putative 0.0417 0.2918 1
Echinococcus multilocularis zinc finger protein 0.0043 0.0202 0.0196
Loa Loa (eye worm) hypothetical protein 0.0221 0.1497 0.5122
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0152 0.0519
Echinococcus granulosus peregrin 0.0061 0.0337 0.0332
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.0188 0.0645
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.078 1
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0252 0.1716 0.1712
Echinococcus granulosus peroxidasin 0.0221 0.1497 0.1493
Echinococcus multilocularis jumonji domain containing protein 0.0079 0.0463 0.0458
Loa Loa (eye worm) notch protein 0.0034 0.0135 0.0443
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0023 0.0017
Schistosoma mansoni hypothetical protein 0.0098 0.0603 0.0597
Loa Loa (eye worm) hypothetical protein 0.0221 0.1497 0.5122
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0225 0.0219
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.078 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0056 0.0297 0.0292
Leishmania major trypanothione reductase 0.0046 0.0225 0.077
Onchocerca volvulus Matrilysin homolog 0.0069 0.0393 0.1246
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0058 0.0199
Loa Loa (eye worm) hypothetical protein 0.0069 0.0393 0.133
Schistosoma mansoni sex comb on midleg homolog 0.0096 0.059 0.0584
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0317 0.1069
Schistosoma mansoni lipoxygenase 0.002 0.0034 0.0028
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0059 0.0322 0.1082
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0737 0.2509
Onchocerca volvulus 0.0041 0.0192 0.0547
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0007 0.0001
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0022 0.0052 0.0583
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0188 0.0627
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0124 0.079 0.0785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0259
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0052 0.0177
Loa Loa (eye worm) hypothetical protein 0.0143 0.0927 0.3163
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0281 0.0965
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.0052 0.0155
Brugia malayi Cytochrome P450 family protein 0.0082 0.0482 0.1637
Loa Loa (eye worm) hypothetical protein 0.0221 0.1497 0.5122
Onchocerca volvulus Neurogenic locus notch homolog 0.0034 0.0135 0.035
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0152 0.0146
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0052 0.0046
Leishmania major hypothetical protein, conserved 0.0035 0.0143 0.0489
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0028 0.0074
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0059 0.0322 0.1082
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0007 0.0022
Schistosoma mansoni notch 0.0034 0.0135 0.0129
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0126 0.043
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0291 0.0285
Loa Loa (eye worm) hypothetical protein 0.0221 0.1497 0.5122
Onchocerca volvulus 0.0034 0.0135 0.035
Schistosoma mansoni hypothetical protein 0.0507 0.3569 0.3565
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0081 0.0256
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0126 0.012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0035
Loa Loa (eye worm) hypothetical protein 0.0417 0.2918 1
Schistosoma mansoni hypothetical protein 0.002 0.0034 0.0028
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0652 0.2217
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0033 0.0131 0.0126
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0058 0.0668
Onchocerca volvulus 0.0034 0.0135 0.035
Schistosoma mansoni hypothetical protein 0.0031 0.0115 0.0109
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0084 0.0502 0.1703
Brugia malayi Animal haem peroxidase family protein 0.0221 0.1497 0.5122
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0652 0.2217
Brugia malayi Animal haem peroxidase family protein 0.0221 0.1497 0.5122
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0126 0.0409
Echinococcus granulosus single minded 2 0.0041 0.0192 0.0186
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0096 0.059 0.0584
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0126 0.0409
Plasmodium falciparum JmjC domain-containing protein, putative 0.0035 0.0143 0.0468
Mycobacterium leprae PROBABLE HYDROLASE 0.0084 0.0502 0.6691
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0126 0.0409
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0019 0.0028 0.0074
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0152 0.0519
Loa Loa (eye worm) hypothetical protein 0.0096 0.059 0.2005
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0322 0.1082
Leishmania major cytochrome p450-like protein 0.0022 0.0052 0.0177
Brugia malayi MH2 domain containing protein 0.0232 0.1576 0.5391
Plasmodium vivax JmjC domain containing protein 0.0035 0.0143 0.0468
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.078 0.0775
Schistosoma mansoni cpg binding protein 0.0066 0.0369 0.0364
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.0733 0.2495
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0026 0.0081 0.0075
Echinococcus granulosus JmjC domain containing protein 4 0.0035 0.0143 0.0137
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0022 0.0052 0.0583
Brugia malayi cytochrome P450 0.0022 0.0052 0.0158
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.018
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0059 0.0322 0.1082
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0126 0.0409
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0281 0.0965
Loa Loa (eye worm) hypothetical protein 0.0114 0.0715 0.2437
Onchocerca volvulus Matrilysin homolog 0.0154 0.1005 0.3366
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0034 0.0093
Echinococcus granulosus neurogenic locus protein delta 0.0034 0.0135 0.0129
Echinococcus granulosus histone acetyltransferase MYST2 0.011 0.0686 0.0681
Brugia malayi PAS domain containing protein 0.0056 0.0297 0.1001
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0322 0.1082
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0322 0.1082
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0022 0.0052 0.0155
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0124 0.0404
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.0052 0.0155
Schistosoma mansoni ap endonuclease 0.0038 0.017 0.0164
Schistosoma mansoni notch 0.0034 0.0135 0.0129
Brugia malayi Bromodomain containing protein 0.0061 0.0337 0.1138
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0034 0.0028
Brugia malayi bHLH-PAS transcription factor 0.0041 0.0192 0.0638
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0096
Schistosoma mansoni jumonji/arid domain-containing protein 0.0137 0.0888 0.0883
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0269 0.09
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.017 0.0561
Onchocerca volvulus 0.0221 0.1497 0.5074
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0026 0.0081 0.0075
Schistosoma mansoni polycystin 1-related 0.002 0.0034 0.0028
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0252 0.1716 0.1712
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0025 0.0065
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0281 0.0944
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0225 0.077
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.011 0.0686 0.2337
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0141 0.0135
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0124 0.1356
Loa Loa (eye worm) hypothetical protein 0.0077 0.0453 0.1536
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0081 0.0256
Brugia malayi CXXC zinc finger family protein 0.0059 0.0317 0.1069
Brugia malayi EGF-like domain containing protein 0.0034 0.0135 0.0443
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0034 0.0135 0.0129
Brugia malayi EGF-like domain containing protein 0.0034 0.0135 0.0443
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0022 0.0052 0.0583
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0141 0.0135
Onchocerca volvulus Peroxidasin homolog 0.0221 0.1497 0.5074
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0652 0.2217
Plasmodium falciparum phd finger protein, putative 0.0057 0.0302 0.1016
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.1165 0.3922
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.017 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0322 0.1082
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0322 0.1082
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0016 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.0052 0.0155
Schistosoma mansoni hypothetical protein 0.0057 0.0302 0.0297
Echinococcus multilocularis fibropellin Ia 0.0034 0.0135 0.0129
Brugia malayi Matrixin family protein 0.0069 0.0393 0.133
Loa Loa (eye worm) cytochrome P450 family protein 0.0082 0.0482 0.1637
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0152 0.0326
Brugia malayi eukaryotic initiation factor 4A 0.0417 0.2918 1
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0034 0.0135 0.0443
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0026 0.0081 0.0075
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0059 0.0322 0.1102
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Echinococcus granulosus slit 2 protein 0.0034 0.0135 0.0129
Brugia malayi Bromodomain containing protein 0.0077 0.0452 0.1532
Loa Loa (eye worm) matrixin family protein 0.0167 0.1105 0.3774
Brugia malayi AF-10 protein 0.0019 0.0025 0.0068
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0035
Brugia malayi jmjC domain containing protein 0.0035 0.0143 0.0471
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0034 0.0028
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0035 0.0143 0.0468
Onchocerca volvulus 0.0069 0.0393 0.1246
Brugia malayi Matrixin family protein 0.0069 0.0393 0.133
Schistosoma mansoni hypothetical protein 0.0019 0.0025 0.002
Loa Loa (eye worm) CYP4Cod1 0.0041 0.0188 0.0627
Loa Loa (eye worm) cytochrome P450 0.0022 0.0052 0.0158
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.015 0.0494
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.015 0.0144
Leishmania major eukaryotic initiation factor 4a, putative 0.0417 0.2918 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Brugia malayi EGF-like domain containing protein 0.0034 0.0135 0.0443
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Loa Loa (eye worm) hypothetical protein 0.0221 0.1497 0.5122
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0225 0.0752
Echinococcus granulosus protein jagged 1 0.0034 0.0135 0.0129
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0035
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0023 0.0059
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0022 0.0052 0.0583
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0059 0.0322 0.1082
Brugia malayi Matrixin family protein 0.0069 0.0393 0.133
Echinococcus multilocularis neurogenic locus protein delta 0.0034 0.0135 0.0129
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0026 0.0081 0.0259
Loa Loa (eye worm) hypothetical protein 0.0188 0.1254 0.4285
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0058 0.0668
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0322 0.1082
Loa Loa (eye worm) hypothetical protein 0.0026 0.0078 0.0247
Echinococcus multilocularis transfer RNA-Lys 0.0041 0.0192 0.0186
Echinococcus multilocularis neuropeptide receptor A26 0.045 0.3154 0.315
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0075
Toxoplasma gondii exonuclease III APE 0.0038 0.017 0.0561
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0007 0.0022
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0022 0.0052 0.0583
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.0052 0.0155
Echinococcus granulosus fetal alzheimer antigen falz 0.0049 0.0245 0.024
Loa Loa (eye worm) hypothetical protein 0.0082 0.0488 0.1655
Trypanosoma cruzi ISWI complex protein 0.0031 0.0115 0.0394
Echinococcus granulosus cpg binding protein 0.0066 0.0369 0.0364
Loa Loa (eye worm) hypothetical protein 0.0221 0.1497 0.5122
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0016 0.0032
Brugia malayi Peroxidasin 0.0221 0.1497 0.5122
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.015 0.0144
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0007 0.0022
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0022 0.0052 0.0583
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0124 0.079 0.0785
Onchocerca volvulus Matrix metalloproteinase homolog 0.0154 0.1005 0.3366
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0022 0.0052 0.0583
Loa Loa (eye worm) hypothetical protein 0.011 0.0686 0.2337
Echinococcus granulosus protein jagged 1 0.0034 0.0135 0.0129
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0193 0.0644
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0126 0.012
Echinococcus multilocularis neural cadherin 0.0034 0.0135 0.0129
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0007 0.0003
Schistosoma mansoni myelin transcription factor 1 myt1 0.011 0.0686 0.0681
Schistosoma mansoni cytochrome P450 0.0022 0.0052 0.0046
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0035
Schistosoma mansoni notch 0.0034 0.0135 0.0129
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0016 0.0121
Brugia malayi Animal haem peroxidase family protein 0.0221 0.1497 0.5122
Loa Loa (eye worm) hypothetical protein 0.0089 0.054 0.1834
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.018
Mycobacterium ulcerans hypothetical protein 0.0023 0.0058 0.0668
Brugia malayi GCC2 and GCC3 family protein 0.0034 0.0135 0.0443
Schistosoma mansoni hypothetical protein 0.0034 0.0135 0.0129
Schistosoma mansoni septate junction protein 0.0034 0.0135 0.0129
Leishmania major hypothetical protein, conserved 0.0031 0.0115 0.0394
Loa Loa (eye worm) hypothetical protein 0.0176 0.1165 0.398
Loa Loa (eye worm) Notch2 0.0034 0.0135 0.0443
Schistosoma mansoni jumonji domain containing protein 0.0209 0.1408 0.1403
Echinococcus multilocularis protein jagged 2 0.0034 0.0135 0.0129
Mycobacterium leprae Conserved hypothetical protein 0.0022 0.0052 0.0332
Mycobacterium ulcerans putative regulatory protein 0.0041 0.0192 0.239
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0152 0.8874
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0059 0.0322 0.0316
Schistosoma mansoni zinc finger protein 0.0043 0.0202 0.0196
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0322 0.1082
Loa Loa (eye worm) transcription factor SMAD2 0.0232 0.1576 0.5391
Schistosoma mansoni hypothetical protein 0.0409 0.2854 0.285
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0281 0.0276
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0281 0.0276
Brugia malayi Animal haem peroxidase family protein 0.0221 0.1497 0.5122
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0417 0.2918 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0322 0.1082
Echinococcus granulosus geminin 0.0507 0.3569 0.3565
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0281 0.0944
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.0052 0.0155
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0126 0.0412
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0022 0.0052 0.0583
Onchocerca volvulus 0.0098 0.0603 0.1973
Echinococcus granulosus protein jagged 2 0.0034 0.0135 0.0129
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.017 0.0561
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0417 0.2918 0.2914
Onchocerca volvulus 0.0221 0.1497 0.5074
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0007 0.0022
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0059 0.0322 0.1082
Loa Loa (eye worm) hypoxia-induced factor 1 0.0173 0.1148 0.3922
Schistosoma mansoni protein phosphatase 2C 0.0035 0.0143 0.0137
Brugia malayi EGF-like domain containing protein 0.0034 0.0135 0.0443
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.017 0.0564
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0034 0.0135 0.035
Brugia malayi Calcium binding EGF domain containing protein 0.0034 0.0135 0.0443
Brugia malayi Delta serrate ligand family protein 0.0034 0.0135 0.0443
Brugia malayi Calcium binding EGF domain containing protein 0.0034 0.0135 0.0443
Brugia malayi PHD-finger family protein 0.0026 0.0078 0.0247
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0022 0.0052 0.0583
Echinococcus granulosus eukaryotic initiation factor 4A 0.0417 0.2918 0.2914
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.011 0.0686 0.0681
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.017 0.0561
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.017 0.2112
Echinococcus multilocularis neurogenic locus protein delta 0.0034 0.0135 0.0129
Schistosoma mansoni inositol monophosphatase 0.0036 0.0152 0.0146
Toxoplasma gondii thioredoxin reductase 0.0046 0.0225 0.0749
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0059 0.0322 0.0316
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0009 0.0009
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0035 0.0143 0.0468
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0051 0.0154
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0126 0.012
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0058 0.0199
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Echinococcus granulosus polycomb protein SCMH1 0.0096 0.059 0.0584
Brugia malayi Doublecortin family protein 0.002 0.0034 0.0096
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0281 0.0965
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0019 0.0028 0.0278
Echinococcus multilocularis PHD finger protein rhinoceros 0.0057 0.0302 0.0297
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0052 0.0177
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0417 0.2918 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0137 0.0888 0.0883
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0059 0.0322 0.1082
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0022 0.0052 0.0583
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0126 0.0409
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.0052 0.0155
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.011 0.0686 0.0681
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0022 0.0052 0.0583
Brugia malayi EGF-like domain containing protein 0.0034 0.0135 0.0443
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0322 0.1082
Schistosoma mansoni lipoxygenase 0.0055 0.0291 0.0285
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.017 0.0164
Echinococcus granulosus SAM and MBT domain containing protein 0.0096 0.059 0.0584
Loa Loa (eye worm) hypothetical protein 0.0069 0.0393 0.133
Brugia malayi Cytochrome P450 family protein 0.0041 0.0188 0.0627
Echinococcus multilocularis jumonji domain containing 1A 0.0035 0.0143 0.0137
Brugia malayi hypothetical protein 0.002 0.0034 0.0096
Schistosoma mansoni ap endonuclease 0.0038 0.017 0.0164
Loa Loa (eye worm) pax transcription factor protein 2 0.0259 0.1768 0.6053
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0022 0.0052 0.0583
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0009 0.0009
Onchocerca volvulus 0.0023 0.0058 0.0085
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0042 0.0195 0.0189
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0007 0.0022
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0034 0.0028
Onchocerca volvulus 0.0221 0.1497 0.5074
Brugia malayi PHD-finger family protein 0.0057 0.0302 0.1019
Echinococcus granulosus neural cadherin 0.0034 0.0135 0.0129
Onchocerca volvulus 0.0096 0.059 0.1927
Loa Loa (eye worm) hypothetical protein 0.0057 0.0302 0.1019
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0281 0.0276
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0009 0.0009
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0417 0.2918 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Schistosoma mansoni peroxidasin 0.0221 0.1497 0.1493
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0141 0.0135
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0058 0.0668
Echinococcus multilocularis histone acetyltransferase MYST2 0.011 0.0686 0.0681
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0652 0.2217
Schistosoma mansoni zinc finger protein 0.0031 0.0115 0.0109
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0041 0.0188 0.2348
Brugia malayi Cadherin domain containing protein 0.0034 0.0135 0.0443
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0247 0.1685 0.168
Brugia malayi hypothetical protein 0.0221 0.1497 0.5122
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0281 0.0944
Schistosoma mansoni sex comb on midleg homolog 0.0096 0.059 0.0584
Echinococcus granulosus jumonji domain containing 1A 0.0035 0.0143 0.0137
Plasmodium falciparum GAF domain-related protein, putative 0.0019 0.0028 0.0074
Brugia malayi EGF-like domain containing protein 0.0034 0.0135 0.0443
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0034 0.0093
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0281 0.0276
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0059 0.0322 0.1082
Schistosoma mansoni rab6-interacting 0.002 0.0034 0.0028
Loa Loa (eye worm) animal heme peroxidase 0.0221 0.1497 0.5122
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0152 0.0498
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0007 0.0022
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0281 0.0944
Mycobacterium tuberculosis Probable reductase 0.0105 0.0652 0.2217
Leishmania major cytochrome p450-like protein 0.0022 0.0052 0.0177
Onchocerca volvulus 0.0034 0.0135 0.035
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0007 0.0022
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0025 0.0065
Onchocerca volvulus Dual oxidase homolog 0.0221 0.1497 0.5074
Loa Loa (eye worm) animal heme peroxidase 0.0221 0.1497 0.5122
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.2854 0.285
Brugia malayi jmjC domain containing protein 0.0035 0.0143 0.0471
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.078 0.0775
Brugia malayi hypothetical protein 0.002 0.0034 0.0096
Schistosoma mansoni notch 0.0034 0.0135 0.0129
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0281 0.0947
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0737 1
Toxoplasma gondii aldehyde dehydrogenase 0.0123 0.078 0.2658
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0322 0.1082
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.0052 0.0155
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0387 0.2701 0.2697
Brugia malayi Bromodomain containing protein 0.0155 0.1014 0.3462
Echinococcus multilocularis phd:f box containing protein 0.0035 0.0143 0.0137
Brugia malayi jmjC domain containing protein 0.0035 0.0143 0.0471
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0225 0.0749
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0059 0.0322 0.1102
Brugia malayi glutathione reductase 0.0046 0.0225 0.0752
Brugia malayi Calcium binding EGF domain containing protein 0.0034 0.0135 0.0443
Brugia malayi Thioredoxin reductase 0.0046 0.0225 0.0752
Loa Loa (eye worm) hypothetical protein 0.0221 0.1497 0.5122
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0058 0.0425
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0302 0.1016
Loa Loa (eye worm) animal heme peroxidase 0.0221 0.1497 0.5122
Schistosoma mansoni hypothetical protein 0.0034 0.0135 0.0129
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.0188 0.0645
Echinococcus granulosus notch 0.0034 0.0135 0.0129
Mycobacterium leprae putative cytochrome p450 0.0022 0.0052 0.0332
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0016 0.0032
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0152 0.0146
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0225 0.0749
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0281 0.0965
Brugia malayi Matrixin family protein 0.0069 0.0393 0.133
Schistosoma mansoni hypothetical protein 0.0034 0.0135 0.0129
Giardia lamblia PHD finger protein 15 0.0057 0.0302 0.1016
Echinococcus multilocularis neurogenic locus notch protein 0.0034 0.0135 0.0129
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0322 0.1082
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.004 0.0184 0.0632
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0096 0.059 0.1927
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0141 0.0135
Schistosoma mansoni jumonji domain containing protein 0.0035 0.0143 0.0137
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0302 0.1016
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.017 0.0561
Echinococcus multilocularis protein jagged 1 0.0034 0.0135 0.0129
Brugia malayi Cytochrome P450 family protein 0.0022 0.0052 0.0158
Onchocerca volvulus Slit protein homolog 0.0034 0.0135 0.035
Treponema pallidum ATP-dependent RNA helicase 0.0417 0.2918 1
Echinococcus multilocularis neurogenic locus notch protein 0.0034 0.0135 0.0129
Echinococcus multilocularis SAM and MBT domain containing protein 0.0096 0.059 0.0584
Echinococcus multilocularis polycomb protein SCMH1 0.0096 0.059 0.0584
Schistosoma mansoni hypothetical protein 0.0034 0.0135 0.0129
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0007 0.0001
Echinococcus multilocularis cpg binding protein 0.0066 0.0369 0.0364
Brugia malayi MAP kinase sur-1 0.0054 0.0281 0.0947
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0123 0.078 0.0775
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0143 0.0471
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0058 0.0668
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0417 0.0412
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.017 0.0391
Schistosoma mansoni hypothetical protein 0.0022 0.0052 0.0046
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.017 0.0582
Echinococcus multilocularis 0.0022 0.0052 0.0046
Schistosoma mansoni cpg binding protein 0.0059 0.0317 0.0312
Echinococcus multilocularis neurogenic locus notch protein 4 0.0034 0.0135 0.0129
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.004 0.0184 0.0611
Echinococcus granulosus PHD finger protein rhinoceros 0.0057 0.0302 0.0297
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.0052 0.0155
Echinococcus granulosus zinc finger protein 0.0043 0.0202 0.0196
Schistosoma mansoni loxhd1 0.002 0.0034 0.0028
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0034 0.0028
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0143 0.0471
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0019 0.0028 0.0074
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0096
Schistosoma mansoni inositol monophosphatase 0.0036 0.0152 0.0146
Echinococcus granulosus phd:f box containing protein 0.0035 0.0143 0.0137
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0143 0.0489
Leishmania major cytochrome p450-like protein 0.0041 0.0188 0.0645
Onchocerca volvulus 0.0034 0.0135 0.035
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0022 0.0052 0.0583
Brugia malayi Matrixin family protein 0.0167 0.1105 0.3774
Echinococcus multilocularis peregrin 0.0061 0.0337 0.0332
Brugia malayi hypoxia-induced factor 1 0.0173 0.1148 0.3922
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.017 0.0582
Echinococcus multilocularis notch 0.0034 0.0135 0.0129
Toxoplasma gondii hypothetical protein 0.0019 0.0028 0.0074
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0007 0.0022
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0737 0.2509
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0443
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0058 0.0668
Loa Loa (eye worm) glutathione reductase 0.0046 0.0225 0.0752
Loa Loa (eye worm) mbt repeat family protein 0.0096 0.059 0.2005
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0022 0.0052 0.0583
Mycobacterium ulcerans hydrolase 0.0084 0.0502 0.6408
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0022 0.0052 0.0583
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0007 0.0022
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0417 0.2918 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8199 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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