Detailed information for compound 1434246

Basic information

Technical information
  • TDR Targets ID: 1434246
  • Name: [1-(2,6-dimethylpyrimidine-4-carbonyl)piperid in-3-yl]-naphthalen-1-ylmethanone
  • MW: 373.448 | Formula: C23H23N3O2
  • H donors: 0 H acceptors: 4 LogP: 3.88 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nc(C)nc(c1)C(=O)N1CCCC(C1)C(=O)c1cccc2c1cccc2
  • InChi: 1S/C23H23N3O2/c1-15-13-21(25-16(2)24-15)23(28)26-12-6-9-18(14-26)22(27)20-11-5-8-17-7-3-4-10-19(17)20/h3-5,7-8,10-11,13,18H,6,9,12,14H2,1-2H3
  • InChiKey: CBQZSDNYCVJPGB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [1-(2,6-dimethylpyrimidine-4-carbonyl)-3-piperidyl]-(1-naphthyl)methanone
  • [1-[(2,6-dimethyl-4-pyrimidinyl)-oxomethyl]-3-piperidinyl]-(1-naphthyl)methanone
  • [1-(2,6-dimethylpyrimidin-4-yl)carbonylpiperidin-3-yl]-naphthalen-1-yl-methanone
  • MLS000734488
  • SMR000316305
  • {1-[(2,6-dimethylpyrimidin-4-yl)carbonyl]piperidin-3-yl}(1-naphthyl)methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0153 0.0946 0.1014
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0242 0.1898 0.2317
Plasmodium falciparum calcium-dependent protein kinase 1 0.0141 0.0819 0.761
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0223 0.1688 0.206
Echinococcus granulosus casein kinase I alpha 0.0113 0.0508 0.0508
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0127 0.0664 0.1675
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0308 0.0653
Loa Loa (eye worm) AGC/PKA protein kinase 0.0117 0.0554 0.0593
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0223 0.1689 0.2062
Trypanosoma brucei cdc2-related kinase 3 0.0122 0.0614 0.1615
Echinococcus multilocularis Diacylglycerol kinase theta 0.011 0.0477 0.0582
Echinococcus multilocularis cyclin dependent kinase 9 0.0091 0.0273 0.0333
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0132 0.0716 0.0767
Echinococcus multilocularis TGF beta receptor type 1 0.0109 0.0468 0.0571
Entamoeba histolytica protein kinase, putative 0.0076 0.0115 0.01
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0178 0.1206 0.1292
Loa Loa (eye worm) phosphatidylinositol 3 0.0112 0.0506 0.0543
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0088 0.0249 0.0484
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.012 0.0587 0.0717
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0212 0.1577 0.4296
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0142 0.0823 0.1964
Trichomonas vaginalis CAMK family protein kinase 0.013 0.0692 0.1756
Schistosoma mansoni Neurotrimin precursor (hNT) 0.009 0.0266 0.0431
Brugia malayi Pleckstrin Homology Domain 0.0118 0.057 0.0611
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.1316 0.3547
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0119 0.0575 0.0575
Brugia malayi Protein kinase domain containing protein 0.092 0.9164 0.9819
Entamoeba histolytica protein kinase, putative 0.0127 0.0661 0.1667
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0157 0.0984 0.1595
Schistosoma mansoni protein kinase 0.0246 0.1944 0.3149
Echinococcus granulosus RNA directed DNA polymerase 0.0192 0.1359 0.1359
Entamoeba histolytica hypothetical protein 0.0335 0.2894 0.808
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.1309 0.2121
Brugia malayi Stress-activated protein kinase jnk-1 0.0488 0.4527 0.4851
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0794 0.2048
Echinococcus granulosus CDC7 cell division cycle 7 0.0094 0.0312 0.0312
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0308 0.0653
Brugia malayi Immunoglobulin I-set domain containing protein 0.0084 0.0198 0.0212
Schistosoma mansoni ephrin receptor 0.0074 0.0093 0.0151
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0589 0.5612 0.6013
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0312 0.0505
Loa Loa (eye worm) hypothetical protein 0.0073 0.0081 0.0086
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0335 0.2894 0.808
Trypanosoma brucei Casein kinase II 0.0104 0.0419 0.1027
Entamoeba histolytica protein kinase, putative 0.0088 0.0243 0.0465
Onchocerca volvulus 0.0094 0.0312 0.025
Brugia malayi serine/threonine protein kinase 6 0.0148 0.0891 0.0954
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0284 0.2343 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0119 0.0573 0.0573
Trichomonas vaginalis STE family protein kinase 0.0127 0.0661 0.1667
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0084 0.02 0.0214
Brugia malayi Protein kinase domain containing protein 0.0094 0.0312 0.0334
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0242 0.1898 0.2317
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0419 0.0973
Mycobacterium ulcerans hypothetical protein 0.0099 0.0358 0.5
Loa Loa (eye worm) hypothetical protein 0.0073 0.0081 0.0086
Schistosoma mansoni tyrosine kinase 0.0119 0.0573 0.0929
Trichomonas vaginalis AGC family protein kinase 0.0381 0.338 0.9475
Echinococcus multilocularis cyclin dependent kinase 7 0.0114 0.0521 0.0637
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0202 0.1465 0.157
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.012 0.0587 0.0587
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0141 0.0819 0.1949
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.0884 0.1432
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0159 0.1006 0.1006
Schistosoma mansoni serine/threonine protein kinase 0.0164 0.1057 0.1712
Echinococcus multilocularis casein kinase I gamma 0.0214 0.1594 0.1946
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0127 0.0664 0.1675
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0212 0.1577 0.4296
Giardia lamblia Kinase, CK1 Casein kinase 0.0113 0.0508 0.203
Loa Loa (eye worm) TK/FER protein kinase 0.0415 0.3747 0.4015
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0122 0.0614 0.2356
Schistosoma mansoni serine/threonine protein kinase 0.047 0.4334 0.7021
Schistosoma mansoni protein kinase C mu 0.0287 0.238 0.3856
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0117 0.0554 0.4234
Schistosoma mansoni serine/threonine protein kinase 0.0214 0.1594 0.2583
Schistosoma mansoni serine/threonine protein kinase 0.0304 0.2561 0.4149
Plasmodium vivax serine/threonine protein kinase, putative 0.0088 0.0243 0.1474
Echinococcus granulosus serine:threonine protein kinase 0.0078 0.0143 0.0143
Echinococcus granulosus serine threonine protein kinase nrc 0.0159 0.1006 0.1006
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0117 0.0554 0.0554
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0415 0.3747 0.3747
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0108 0.0463 0.1159
Echinococcus multilocularis protein kinase shaggy 0.0132 0.0716 0.0874
Loa Loa (eye worm) hypothetical protein 0.0108 0.0463 0.0496
Trypanosoma cruzi cdc2-related kinase 1 0.0122 0.0614 0.153
Trypanosoma cruzi polo-like protein kinase, putative 0.0269 0.2187 0.6048
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0078 0.0143 0.0154
Echinococcus multilocularis PAK box P21 Rho binding 0.0085 0.0211 0.0257
Schistosoma mansoni rac gtpase activating protein 0.011 0.0477 0.0773
Brugia malayi Protein kinase domain containing protein 0.0156 0.0975 0.1045
Echinococcus multilocularis epidermal growth factor receptor 0.0604 0.5778 0.7054
Trichomonas vaginalis AGC family protein kinase 0.0381 0.338 0.9475
Schistosoma mansoni kinase 0.0287 0.2379 0.3853
Echinococcus granulosus tyrosine protein kinase Fyn 0.0242 0.1898 0.1898
Brugia malayi Protein kinase domain containing protein 0.0555 0.5251 0.5627
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0127 0.0661 0.0807
Loa Loa (eye worm) hypothetical protein 0.0141 0.0819 0.0877
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.092 0.9164 0.9819
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0142 0.0823 0.0882
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0086 0.0226 0.0276
Echinococcus multilocularis hypothetical protein 0.0069 0.0043 0.0053
Entamoeba histolytica cell division protein kinase 2, putative 0.0122 0.0614 0.153
Entamoeba histolytica casein kinase, putative 0.0113 0.0508 0.1228
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0121 0.0596 0.0638
Echinococcus multilocularis cyclin dependent kinase 19 0.0166 0.1084 0.1323
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0308 0.0653
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0187 0.1309 0.1598
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0308 0.0653
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0148 0.0891 0.2326
Trichomonas vaginalis STE family protein kinase 0.0183 0.1263 0.3395
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.1465 0.2373
Echinococcus granulosus mitogen activated protein kinase 11 0.0284 0.2343 0.2343
Brugia malayi Protein kinase domain containing protein 0.0086 0.0226 0.0242
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0269 0.2187 0.267
Loa Loa (eye worm) AGC/AKT protein kinase 0.0381 0.338 0.3622
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0094 0.0308 0.1006
Trichomonas vaginalis CMGC family protein kinase 0.0122 0.0614 0.153
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0486 0.4515 0.5511
Brugia malayi diacylglycerol kinase 0.011 0.0477 0.0511
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0463 0.075
Schistosoma mansoni serine/threonine protein kinase 0.0223 0.1688 0.2734
Echinococcus granulosus titin 0.0084 0.0198 0.0198
Trichomonas vaginalis CMGC family protein kinase 0.0122 0.0614 0.153
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0159 0.1006 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0076 0.0115 0.0115
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0096 0.0329 0.0712
Trichomonas vaginalis STE family protein kinase 0.0127 0.0661 0.1667
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0109 0.0468 0.0571
Loa Loa (eye worm) hypothetical protein 0.011 0.0477 0.0511
Toxoplasma gondii CMGC kinase, CK2 family 0.0104 0.0419 0.0647
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0174 0.1164 0.1885
Loa Loa (eye worm) hypothetical protein 0.0094 0.0308 0.033
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0566 0.5365 0.5365
Echinococcus multilocularis serine:threonine protein kinase N2 0.0378 0.3349 0.4089
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0108 0.0463 0.075
Trypanosoma brucei polo-like protein kinase 0.0269 0.2187 0.6384
Echinococcus multilocularis cyclin dependent kinase 1 0.0122 0.0614 0.0749
Loa Loa (eye worm) hypothetical protein 0.011 0.0477 0.0511
Echinococcus multilocularis N chimaerin 0.0174 0.1164 0.1421
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0086 0.0226 0.0226
Trypanosoma cruzi casein kinase, putative 0.0113 0.0508 0.1228
Brugia malayi Protein kinase domain containing protein 0.0096 0.0331 0.0355
Entamoeba histolytica hypothetical protein 0.0368 0.325 0.9102
Schistosoma mansoni pyruvate dehydrogenase 0.011 0.0476 0.0772
Loa Loa (eye worm) TK protein kinase 0.0276 0.226 0.2422
Echinococcus multilocularis dual specificity 0.0142 0.0823 0.1005
Loa Loa (eye worm) TK/FER protein kinase 0.0121 0.0596 0.0639
Loa Loa (eye worm) TK/INSR protein kinase 0.0447 0.409 0.4382
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0117 0.0554 0.1358
Onchocerca volvulus 0.0257 0.2054 0.2133
Schistosoma mansoni growth factor receptor-bound protein 0.0104 0.0415 0.0672
Schistosoma mansoni tyrosine kinase 0.0604 0.5778 0.9361
Schistosoma mansoni serine/threonine protein kinase 0.0349 0.3042 0.4928
Echinococcus multilocularis tyrosine kinase 0.0121 0.0596 0.0728
Echinococcus multilocularis cyclin B 0.0073 0.0081 0.0099
Echinococcus multilocularis 0.0156 0.097 0.1185
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0108 0.0463 0.075
Schistosoma mansoni kinase 0.0083 0.0191 0.0309
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0488 0.4527 0.5526
Entamoeba histolytica protein kinase, putative 0.0212 0.1577 0.4296
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0139 0.0794 0.1868
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0103 0.0409 0.0942
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0398 0.3563 0.3818
Trichomonas vaginalis CAMK family protein kinase 0.0269 0.2187 0.6048
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0127 0.0664 0.1675
Onchocerca volvulus 0.0121 0.0595 0.0556
Echinococcus granulosus dual specificity 0.0142 0.0823 0.0823
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0147 0.0883 0.0883
Schistosoma mansoni tyrosine kinase 0.0346 0.3009 0.4875
Loa Loa (eye worm) hypothetical protein 0.0471 0.4348 0.4659
Echinococcus granulosus mitogen activated protein kinase 3 0.0088 0.0249 0.0249
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0132 0.0716 0.1825
Onchocerca volvulus 0.0121 0.0596 0.0557
Echinococcus granulosus NDR protein kinase 0.0252 0.2003 0.2003
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0183 0.1263 0.1353
Entamoeba histolytica protein kinase, putative 0.0142 0.0823 0.2132
Entamoeba histolytica protein kinase domain containing protein 0.0148 0.0891 0.2326
Schistosoma mansoni serine/threonine protein kinase 0.0641 0.6173 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0112 0.0506 0.1223
Echinococcus multilocularis casein kinase i 0.0113 0.0508 0.062
Brugia malayi RhoGAP domain containing protein 0.011 0.0477 0.0511
Plasmodium vivax tyrosine kinase-like protein, putative 0.0086 0.0221 0.1232
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0398 0.3563 1
Echinococcus multilocularis transfer RNA-Thr 0.0218 0.1634 0.1994
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0372 0.3287 0.3522
Trichomonas vaginalis STE family protein kinase 0.0183 0.1263 0.3395
Brugia malayi Furin-like cysteine rich region family protein 0.0604 0.5778 0.6192
Echinococcus multilocularis myotubularin protein 13 0.0118 0.057 0.0696
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0113 0.0508 0.0545
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0148 0.0891 0.1087
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0117 0.0554 0.0554
Loa Loa (eye worm) hypothetical protein 0.009 0.0266 0.0285
Entamoeba histolytica protein kinase, putative 0.0086 0.0226 0.0417
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0389 0.3474 0.3474
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0148 0.0891 0.0891
Entamoeba histolytica protein kinase 2, putative 0.0159 0.1006 0.2659
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0246 0.1944 0.2373
Trichomonas vaginalis CAMK family protein kinase 0.0269 0.2187 0.6048
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0641 0.6173 0.6614
Schistosoma mansoni tyrosine kinase 0.0403 0.3616 0.5858
Trypanosoma brucei developmentally regulated phosphoprotein 0.0116 0.0545 0.1408
Echinococcus granulosus tyrosine protein kinase Srms 0.0516 0.4831 0.4831
Giardia lamblia Kinase, CMGC MAPK 0.0088 0.0249 0.0801
Echinococcus granulosus casein kinase i 0.0113 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.0447 0.4095 0.4388
Loa Loa (eye worm) hypothetical protein 0.0111 0.0488 0.0523
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0121 0.0596 0.148
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0174 0.1164 0.1247
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0088 0.0243 0.0491
Plasmodium vivax serine/threonine kinase-1, putative 0.0156 0.0975 0.9654
Brugia malayi Protein kinase domain containing protein 0.0121 0.0596 0.0639
Trypanosoma cruzi cdc2-related kinase 1 0.0122 0.0614 0.153
Leishmania major protein kinase A catalytic subunit isoform 1 0.0117 0.0554 0.209
Trypanosoma cruzi p21-activated kinase 3, putative 0.0081 0.0172 0.0264
Trichomonas vaginalis AGC family protein kinase 0.0261 0.2096 0.5786
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0308 0.0653
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0086 0.0226 0.0242
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0284 0.2343 0.2511
Schistosoma mansoni protein kinase 0.0085 0.0211 0.0341
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0349 0.3042 0.3201
Brugia malayi Doublecortin family protein 0.0153 0.0946 0.1014
Brugia malayi Protein kinase domain containing protein 0.0088 0.0243 0.026
Loa Loa (eye worm) hypothetical protein 0.0108 0.0463 0.0496
Echinococcus granulosus TGF-beta receptor type-1 0.0109 0.0468 0.0468
Brugia malayi Variant SH3 domain containing protein 0.0174 0.1164 0.1247
Loa Loa (eye worm) TK protein kinase 0.0142 0.0823 0.0882
Entamoeba histolytica protein kinase, putative 0.0142 0.0823 0.2131
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0159 0.1006 1
Brugia malayi phosphoinositide-dependent protein kinase I 0.0086 0.0226 0.0242
Loa Loa (eye worm) hypothetical protein 0.0071 0.0069 0.0074
Echinococcus granulosus protein kinase shaggy 0.0132 0.0716 0.0716
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0132 0.0716 0.0874
Echinococcus multilocularis serine:threonine protein kinase 0.0078 0.0143 0.0175
Echinococcus granulosus cGMP dependent protein kinase 0.0138 0.0778 0.0778
Brugia malayi Cyclin, N-terminal domain containing protein 0.0073 0.0081 0.0086
Echinococcus granulosus tyrosine protein kinase Src42A 0.0153 0.094 0.094
Echinococcus granulosus serine:threonine protein kinase N2 0.0308 0.2599 0.2599
Toxoplasma gondii AGC kinase 0.0117 0.0554 0.1085
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0078 0.0143 0.0154
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0242 0.1898 0.2317
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0141 0.0819 0.0877
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.0312 0.0664
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0242 0.1898 0.2317
Brugia malayi Protein kinase domain containing protein 0.0363 0.3189 0.3417
Echinococcus multilocularis cyclin dependent kinase 9 0.0083 0.0191 0.0233
Echinococcus granulosus nervana 2 0.012 0.0587 0.0587
Schistosoma mansoni vam6/vps39 related 0.0108 0.0463 0.075
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0156 0.0975 0.2569
Trypanosoma brucei casein kinase I, isoform 2 0.0113 0.0508 0.1296
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0084 0.0198 0.0212
Leishmania major developmentally regulated phosphoprotein-like protein 0.0116 0.0545 0.2054
Brugia malayi Protein kinase domain containing protein 0.0121 0.0596 0.0639
Schistosoma mansoni serine/threonine protein kinase 0.0304 0.2561 0.4149
Schistosoma mansoni adapter molecule crk 0.01 0.0378 0.0612
Loa Loa (eye worm) hypothetical protein 0.0115 0.0538 0.0577
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0192 0.1359 0.1659
Loa Loa (eye worm) hypothetical protein 0.0138 0.0786 0.0842
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0308 0.0653
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0156 0.097 0.104
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.0823 0.1333
Plasmodium falciparum serine/threonine protein kinase, putative 0.0148 0.0891 0.8527
Loa Loa (eye worm) variant SH3 domain-containing protein 0.011 0.0477 0.0511
Trichomonas vaginalis AGC family protein kinase 0.0381 0.338 0.9475
Loa Loa (eye worm) CDC7 protein kinase 0.0094 0.0312 0.0334
Loa Loa (eye worm) hypothetical protein 0.0537 0.5058 0.542
Echinococcus multilocularis titin 0.0084 0.0198 0.0241
Echinococcus multilocularis activin receptor type 0.0451 0.4137 0.505
Echinococcus multilocularis dual specificity protein kinase clk2 0.0156 0.0975 0.1191
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0116 0.0545 0.0666
Loa Loa (eye worm) raf kinase 0.011 0.0477 0.0511
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0488 0.4527 0.4851
Giardia lamblia Kinase, NEK 0.0139 0.0794 0.3385
Echinococcus granulosus cyclin dependent kinase 5 0.0122 0.0614 0.0614
Trichomonas vaginalis AGC family protein kinase 0.0148 0.0891 0.2326
Brugia malayi Hr1 repeat family protein 0.0378 0.3349 0.3589
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0141 0.0819 0.1
Loa Loa (eye worm) hypothetical protein 0.0232 0.1793 0.1921
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0166 0.1084 0.1323
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0442 0.4039 0.4328
Loa Loa (eye worm) hypothetical protein 0.0192 0.1359 0.1456
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0252 0.2003 0.2003
Echinococcus granulosus expressed protein 0.0088 0.0243 0.0243
Echinococcus granulosus nervana 2 0.012 0.0587 0.0587
Echinococcus multilocularis dual specificity 0.0142 0.0823 0.1005
Onchocerca volvulus Tyrosine kinase homolog 0.0555 0.5246 0.5583
Trypanosoma brucei protein kinase, putative 0.0096 0.0332 0.076
Echinococcus multilocularis cyclin dependent kinase 0.0122 0.0614 0.0749
Schistosoma mansoni hypothetical protein 0.0069 0.0043 0.007
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0096 0.0332 0.0332
Echinococcus granulosus cyclin dependent kinase 0.0122 0.0614 0.0614
Entamoeba histolytica protein kinase domain containing protein 0.0104 0.0419 0.0973
Echinococcus multilocularis insulin receptor 0.0447 0.409 0.4992
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0151 0.0923 0.0989
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0225 0.1712 0.1712
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0096 0.0331 0.0355
Schistosoma mansoni serine/threonine-protein kinase 0.0168 0.1099 0.1781
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0242 0.1898 0.2317
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0308 0.0653
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0117 0.0554 0.1085
Echinococcus multilocularis tyrosine protein kinase shark 0.0535 0.5031 0.6142
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0249 0.1969 0.1969
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0117 0.0554 0.0676
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0089 0.0259 0.0512
Schistosoma mansoni serine/threonine protein kinase 0.0141 0.0819 0.1326
Echinococcus multilocularis cyclin dependent kinase 1 0.0122 0.0614 0.0749
Schistosoma mansoni hypothetical protein 0.011 0.0477 0.0773
Schistosoma mansoni protein kinase 0.0127 0.0661 0.1071
Schistosoma mansoni tyrosine kinase 0.0102 0.0398 0.0645
Entamoeba histolytica protein kinase, putative 0.0381 0.338 0.9475
Loa Loa (eye worm) hypothetical protein 0.0083 0.0194 0.0208
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0252 0.2003 0.2445
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0088 0.0243 0.0071
Loa Loa (eye worm) TK/FER protein kinase 0.0121 0.0596 0.0639
Brugia malayi Immunoglobulin I-set domain containing protein 0.0276 0.226 0.2422
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0117 0.0554 0.0554
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.1084 0.1756
Echinococcus multilocularis nervana 2 0.012 0.0587 0.0717
Trypanosoma cruzi cdc2-related kinase 3 0.0122 0.0614 0.153
Schistosoma mansoni titin 0.0084 0.0198 0.032
Echinococcus multilocularis Immunoglobulin 0.009 0.0266 0.0325
Loa Loa (eye worm) hypothetical protein 0.0121 0.0595 0.0638
Giardia lamblia Kinase, AGC PKA 0.0117 0.0554 0.2245
Echinococcus granulosus cyclin B 0.0073 0.0081 0.0081
Schistosoma mansoni serine/threonine protein kinase 0.0564 0.5351 0.8669
Entamoeba histolytica protein kinase domain containing protein 0.0132 0.0716 0.1825
Loa Loa (eye worm) hypothetical protein 0.0138 0.078 0.0835
Entamoeba histolytica protein kinase, putative 0.0141 0.0819 0.2119
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0204 0.1484 0.1484
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0206 0.151 0.151
Trichomonas vaginalis CMGC family protein kinase 0.0088 0.0249 0.0484
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0127 0.0664 0.1768
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.016 0.102 0.2699
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0242 0.0462
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0202 0.1464 0.1464
Echinococcus multilocularis raf serine:threonine protein kinase 0.0166 0.1084 0.1323
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0108 0.0463 0.1098
Trichomonas vaginalis CAMK family protein kinase 0.0269 0.2187 0.6048
Echinococcus granulosus dual specificity 0.0212 0.1577 0.1577
Loa Loa (eye worm) hypothetical protein 0.0589 0.5612 0.6013
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0419 0.0973
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0113 0.0508 0.0545
Trichomonas vaginalis CMGC family protein kinase 0.0132 0.0716 0.1825
Echinococcus multilocularis unc 13 (munc13) 0.0121 0.0595 0.0726
Echinococcus granulosus tyrosine protein kinase Src64B 0.0242 0.1898 0.1898
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0088 0.0243 0.026
Echinococcus granulosus protein kinase c epsilon type 0.0641 0.6173 0.6173
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0463 0.075
Echinococcus granulosus activin receptor type 0.0451 0.4137 0.4137
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0141 0.0819 0.1
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.0614 0.0994
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.0312 0.0664
Brugia malayi Protein kinase domain containing protein 0.0188 0.1316 0.141
Plasmodium falciparum cGMP-dependent protein kinase 0.0138 0.0778 0.7086
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0141 0.0819 0.2237
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0823 0.2132
Trichomonas vaginalis STE family protein kinase 0.0183 0.1263 0.3395
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0349 0.3042 0.3259
Loa Loa (eye worm) TK/FER protein kinase 0.0121 0.0596 0.0639
Brugia malayi RhoGAP domain containing protein 0.0174 0.1164 0.1247
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0287 0.238 0.2551
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.011 0.0477 0.0511
Echinococcus granulosus dual specificity 0.0142 0.0823 0.0823
Echinococcus multilocularis Glutaredoxin protein 5 0.012 0.0587 0.0717
Brugia malayi Protein kinase domain containing protein 0.0212 0.1577 0.1689
Schistosoma mansoni tyrosine kinase 0.0302 0.2538 0.4111
Echinococcus multilocularis mitogen activated protein kinase 3 0.0088 0.0249 0.0304
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0198 0.032
Schistosoma mansoni tyrosine kinase 0.0258 0.2064 0.3343
Brugia malayi Protein kinase domain containing protein 0.0121 0.0596 0.0639
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0213 0.1583 0.4315
Echinococcus granulosus protein kinase 0.0156 0.097 0.097
Giardia lamblia Aurora kinase 0.0148 0.0891 0.3846
Echinococcus granulosus tyrosine protein kinase Fyn 0.0242 0.1898 0.1898
Schistosoma mansoni protein kinase 0.0194 0.1382 0.2239
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0119 0.0575 0.0702
Echinococcus granulosus TGF beta receptor type 1 0.0109 0.0468 0.0468
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0156 0.0975 0.2569
Brugia malayi hypothetical protein 0.0223 0.1688 0.1808
Entamoeba histolytica protein kinase, putative 0.0381 0.338 0.9475
Echinococcus multilocularis cyclin dependent kinase 5 0.0122 0.0614 0.0749
Giardia lamblia Kinase, CMGC GSK 0.0132 0.0716 0.3017
Echinococcus multilocularis tyrosine protein kinase HCK 0.0142 0.0823 0.1005
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0242 0.1898 0.2317
Brugia malayi cyclin-dependent kinase 9 0.0083 0.0191 0.0204
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0117 0.0554 0.4944
Brugia malayi Protein kinase domain containing protein 0.0194 0.1382 0.1481
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0521 0.0845
Loa Loa (eye worm) gastrulation defective protein 1 0.0127 0.0665 0.0712
Trypanosoma brucei protein kinase, putative 0.0096 0.0329 0.0752
Loa Loa (eye worm) hypothetical protein 0.009 0.0266 0.0285
Trichomonas vaginalis AGC family protein kinase 0.0086 0.0226 0.0417
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0141 0.0819 0.1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0088 0.0249 0.0484
Schistosoma mansoni tyrosine kinase 0.0535 0.5031 0.8151
Schistosoma mansoni protein kinase 0.0572 0.5432 0.8799
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0398 0.3563 1
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0081 0.0172 0.0264
Schistosoma mansoni tyrosine kinase 0.0157 0.0984 0.1595
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0088 0.0249 0.0484
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0117 0.0554 0.0676
Brugia malayi P38 map kinase family protein 2 0.0284 0.2343 0.2511
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0419 0.0973
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0322 0.275 0.3358
Loa Loa (eye worm) protein kinase domain-containing protein 0.0214 0.1594 0.1709
Brugia malayi bone morphogenetic protein type 1 receptor 0.0126 0.0655 0.0702
Schistosoma mansoni nephrin 0.0134 0.0742 0.1202
Onchocerca volvulus 0.0073 0.0089 0.0009
Echinococcus multilocularis mitogen activated protein kinase 0.0088 0.0249 0.0304
Onchocerca volvulus 0.0094 0.0312 0.025
Brugia malayi SH2 domain containing protein 0.0121 0.0596 0.0639
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0078 0.0134 0.0134
Brugia malayi Cam kinase protein 1 0.0141 0.0819 0.0877
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0088 0.0249 0.0511
Echinococcus granulosus Glutaredoxin protein 5 0.012 0.0587 0.0587
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0122 0.0614 0.0658
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0094 0.0308 0.0376
Trichomonas vaginalis CMGC family protein kinase 0.0122 0.0614 0.153
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0246 0.1944 0.1944
Loa Loa (eye worm) hypothetical protein 0.0139 0.0794 0.0851
Entamoeba histolytica hypothetical protein 0.0212 0.1577 0.4296
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0168 0.1099 0.2925
Trichomonas vaginalis STE family protein kinase 0.0139 0.0794 0.2048
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0104 0.0419 0.0449
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0242 0.1898 0.2317
Entamoeba histolytica protein kinase domain containing protein 0.0083 0.0191 0.0315
Brugia malayi Protein kinase domain containing protein 0.0196 0.14 0.1501
Entamoeba histolytica protein kinase, putative 0.0252 0.2003 0.5519
Schistosoma mansoni serine/threonine protein kinase 0.0117 0.0554 0.0897
Onchocerca volvulus 0.0077 0.0131 0.0055
Loa Loa (eye worm) hypothetical protein 0.0138 0.0786 0.0842
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0187 0.1309 0.1309
Brugia malayi Egg laying defective protein 4 0.0138 0.0778 0.0833
Loa Loa (eye worm) hypothetical protein 0.0218 0.1634 0.1751
Giardia lamblia Kinase, CMGC SRPK 0.0088 0.0243 0.077
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0148 0.0884 0.0884
Brugia malayi putative serine/threonine kinase SADA gamma 0.0094 0.0308 0.033
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.0172 0.0279
Schistosoma mansoni protein kinase 0.0156 0.097 0.1572
Leishmania major protein kinase, putative 0.0089 0.0259 0.0788
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0127 0.0664 0.0711
Loa Loa (eye worm) phosphatidylinositol 3 0.0503 0.4696 0.5032
Giardia lamblia Kinase, STE STE20 0.0183 0.1263 0.5614
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.0975 0.158
Giardia lamblia Kinase, CMGC CDK 0.0122 0.0614 0.253
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0419 0.0973
Schistosoma mansoni pyruvate dehydrogenase 0.011 0.0476 0.0772
Trichomonas vaginalis AGC family protein kinase 0.0252 0.2003 0.5519
Schistosoma mansoni unc-13 (munc13) 0.0121 0.0595 0.0964
Schistosoma mansoni ephrin receptor 0.0172 0.1144 0.1854
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0308 0.0653
Entamoeba histolytica protein kinase domain containing protein 0.0096 0.0329 0.0712
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0132 0.0716 0.0716
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0116 0.0545 0.0545
Brugia malayi Protein kinase domain containing protein 0.0252 0.2003 0.2146
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0183 0.1263 0.3584
Loa Loa (eye worm) hypothetical protein 0.0248 0.1961 0.2101
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0127 0.0661 0.0661
Schistosoma mansoni serine/threonine protein kinase 0.0212 0.1577 0.2554
Plasmodium vivax glycogen synthase kinase 3, putative 0.0132 0.0716 0.6758
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0174 0.1164 0.1885
Echinococcus multilocularis death associated protein kinase 1 0.0829 0.8192 1
Echinococcus multilocularis dual specificity 0.0212 0.1577 0.1925
Onchocerca volvulus 0.0121 0.0596 0.0557
Schistosoma mansoni tyrosine kinase 0.0346 0.3009 0.4875
Brugia malayi STE20-like kinase MST 0.0256 0.2047 0.2194
Loa Loa (eye worm) hypothetical protein 0.0789 0.7758 0.8313
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0117 0.0554 0.0676
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0363 0.3189 0.3417
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0464 0.4274 0.5217
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0183 0.1263 0.1353
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0349 0.3042 0.3042
Schistosoma mansoni protein kinase 0.0127 0.0661 0.1071
Brugia malayi Serine/threonine-protein kinase SULU 0.0223 0.1688 0.1808
Toxoplasma gondii casein kinase I 0.0113 0.0508 0.0937
Trichomonas vaginalis AGC family protein kinase 0.0381 0.338 0.9475
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0132 0.0716 0.116
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0304 0.2561 0.2561
Schistosoma mansoni ste20-related kinase 0.0206 0.151 0.2447
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0284 0.2343 0.6496
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0121 0.0595 0.0595
Echinococcus granulosus tyrosine protein kinase 0.0289 0.24 0.24
Echinococcus multilocularis twitchin 0.0066 0.0014 0.0017
Entamoeba histolytica protein kinase domain containing protein 0.0132 0.0716 0.1825
Echinococcus granulosus activated cdc42 kinase 1 0.0218 0.1634 0.1634
Loa Loa (eye worm) hypothetical protein 0.0073 0.0082 0.0088
Brugia malayi protein-tyrosine kinase 0.0206 0.151 0.1618
Echinococcus granulosus calcium activated potassium channel 0.0108 0.0463 0.0463
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0823 0.2132
Echinococcus multilocularis protein KINase family member (kin 25) 0.0119 0.0573 0.07
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.0778 0.126
Schistosoma mansoni hypothetical protein 0.0108 0.0463 0.075
Onchocerca volvulus 0.0121 0.0596 0.0557
Brugia malayi Kinase associated domain 1 family protein 0.0069 0.0043 0.0046
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0148 0.0884 0.0884
Echinococcus granulosus fibroblast growth factor receptor 4 0.0249 0.1969 0.1969
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0076 0.0115 0.0115
Plasmodium vivax protein kinase Crk2 0.0122 0.0614 0.5614
Brugia malayi Protein kinase domain containing protein 0.0121 0.0596 0.0639
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0117 0.0554 0.1433
Echinococcus granulosus cyclin dependent kinase 9 0.0091 0.0273 0.0273
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0088 0.0249 0.0484
Trichomonas vaginalis CAMK family protein kinase 0.0141 0.0819 0.2119
Schistosoma mansoni protein kinase 0.0104 0.0419 0.068
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0204 0.1484 0.1812
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0242 0.1898 0.1898
Entamoeba histolytica protein kinase, putative 0.0088 0.0243 0.0465
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.024 0.1869 0.8492
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0108 0.0463 0.0565
Brugia malayi Protein kinase domain containing protein 0.0589 0.5612 0.6013
Trichomonas vaginalis CK1 family protein kinase 0.0113 0.0508 0.1228
Brugia malayi Cyclin, N-terminal domain containing protein 0.0073 0.0081 0.0086
Echinococcus granulosus myotubularin protein 13 0.0118 0.057 0.057
Loa Loa (eye worm) hypothetical protein 0.0301 0.2533 0.2715
Giardia lamblia Kinase, PLK 0.0269 0.2187 1
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0159 0.1006 0.1229
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0081 0.0172 0.0185
Schistosoma mansoni growth factor receptor-bound protein 0.01 0.0378 0.0612
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0242 0.1898 0.2317
Trypanosoma brucei rac serine-threonine kinase, putative 0.0381 0.338 1
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0113 0.0508 0.0545
Brugia malayi Protein kinase domain containing protein 0.0381 0.338 0.3622
Plasmodium vivax unspecified product 0.0104 0.0419 0.3447
Trichomonas vaginalis AGC family protein kinase 0.0086 0.0226 0.0417
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0122 0.0614 0.128
Loa Loa (eye worm) TK/EGFR protein kinase 0.0604 0.5778 0.6192
Giardia lamblia Kinase, NEK 0.0139 0.0794 0.3385
Entamoeba histolytica protein kinase, putative 0.0372 0.3287 0.9208
Echinococcus multilocularis serine:threonine protein kinase N2 0.0126 0.0649 0.0793
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0113 0.0508 0.1228
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0096 0.0329 0.0712
Schistosoma mansoni serine/threonine protein kinase 0.0204 0.1484 0.2405
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0088 0.0243 0.0716
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0148 0.0891 0.8708
Echinococcus granulosus casein kinase I delta 0.0113 0.0508 0.0508
Leishmania major casein kinase II, putative 0.0104 0.0419 0.1497
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0191 0.0309
Trypanosoma cruzi casein kinase, putative 0.0113 0.0508 0.1228
Brugia malayi protein kinase C3,putative 0.0229 0.1758 0.1883
Loa Loa (eye worm) IKK protein kinase 0.0936 0.9332 1
Loa Loa (eye worm) AUR protein kinase 0.0148 0.0891 0.0954
Onchocerca volvulus 0.0138 0.0786 0.0762
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0308 0.0653
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0164 0.1057 0.1132
Plasmodium falciparum protein kinase 5 0.0122 0.0614 0.4998
Echinococcus granulosus protein tyrosine kinase 0.0302 0.2538 0.2538
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0141 0.0819 0.1949
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0252 0.2003 0.2003
Schistosoma mansoni tyrosine kinase 0.0346 0.3009 0.4875
Entamoeba histolytica diacylglycerol kinase, putative 0.011 0.0477 0.1138
Loa Loa (eye worm) TK/ROR protein kinase 0.0084 0.0201 0.0215
Schistosoma mansoni protein kinase 0.0148 0.0891 0.1443
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0127 0.0661 0.0807
Brugia malayi diacylglycerol kinase 0.011 0.0477 0.0511
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0088 0.0249 0.0745
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0204 0.1484 0.159
Brugia malayi protein unc-22 0.0084 0.0198 0.0212
Brugia malayi hypothetical protein 0.0108 0.0463 0.0496
Plasmodium falciparum NIMA related kinase 1 0.0139 0.0794 0.7291
Echinococcus granulosus tyrosine protein kinase Src42A 0.0242 0.1898 0.1898
Entamoeba histolytica PH domain containing protein kinase, putative 0.0125 0.0646 0.1625
Brugia malayi Protein kinase domain containing protein 0.0264 0.2132 0.2285
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0096 0.0329 0.0351
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0094 0.0308 0.0653
Trypanosoma brucei cdc2-related kinase 1 0.0122 0.0614 0.1615
Echinococcus multilocularis ephrin type A receptor 4 A 0.0185 0.128 0.1563
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0088 0.0249 0.0745
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0138 0.0778 0.0949
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0108 0.0463 0.0463
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0148 0.0884 0.1079
Plasmodium falciparum protein serine/threonine kinase-1 0.0156 0.0975 0.9605
Echinococcus multilocularis myosin iiia 0.0089 0.0259 0.0316
Loa Loa (eye worm) AGC/PKN protein kinase 0.0378 0.3349 0.3589
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0114 0.0521 0.0559
Entamoeba histolytica protein kinase, putative 0.0152 0.0937 0.2458
Loa Loa (eye worm) AUR protein kinase 0.0148 0.0891 0.0954
Schistosoma mansoni vesicular amine transporter 0.009 0.0266 0.0431
Loa Loa (eye worm) sex muscle abnormal protein 5 0.01 0.0378 0.0405
Trichomonas vaginalis CAMK family protein kinase 0.0269 0.2187 0.6048
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0141 0.0819 0.0877
Brugia malayi kinase, mitochondrial precursor 0.0116 0.0545 0.0584
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0284 0.2343 0.6496
Loa Loa (eye worm) TK/ALK protein kinase 0.0555 0.5249 0.5624
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0132 0.0716 0.0767
Loa Loa (eye worm) TK/FER protein kinase 0.0121 0.0596 0.0639
Schistosoma mansoni serine/threonine protein kinase 0.0389 0.3474 0.5628
Echinococcus multilocularis mitogen activated protein kinase 11 0.0284 0.2343 0.286
Brugia malayi Protein kinase c protein 2 0.0352 0.3071 0.329
Loa Loa (eye worm) hypothetical protein 0.0537 0.5058 0.542
Entamoeba histolytica protein kinase domain containing protein 0.0212 0.1577 0.4296
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0383 0.3406 0.9548
Echinococcus multilocularis dual specificity mitogen activated protein 0.0183 0.1263 0.1542
Onchocerca volvulus 0.0283 0.2337 0.2439
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0166 0.1084 0.1084
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0166 0.1084 0.1162
Schistosoma mansoni tyrosine kinase 0.0447 0.409 0.6625
Echinococcus granulosus serine:threonine kinase SAD 1 0.0094 0.0308 0.0308
Plasmodium falciparum casein kinase 1 0.0113 0.0508 0.3656
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0148 0.0891 0.2326
Trypanosoma cruzi casein kinase II, putative 0.0104 0.0419 0.0973
Echinococcus multilocularis mitogen activated protein kinase 14 0.0284 0.2343 0.286
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0094 0.0308 0.033
Echinococcus granulosus tyrosine protein kinase HCK 0.0142 0.0823 0.0823
Brugia malayi Sex muscle abnormal protein 5 0.01 0.0378 0.0405
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0142 0.0823 0.0882
Schistosoma mansoni tyrosine kinase 0.0249 0.1969 0.3189
Brugia malayi map kinase activated protein kinase protein 2 0.0389 0.3474 0.3723
Schistosoma mansoni serine/threonine-protein kinase 0.0168 0.1099 0.1781
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0104 0.0419 0.0449
Loa Loa (eye worm) TK protein kinase 0.0206 0.151 0.1618
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0142 0.0823 0.3282
Echinococcus multilocularis casein kinase I delta 0.0113 0.0508 0.062
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0088 0.0249 0.0092
Trypanosoma cruzi cdc2-related kinase 3 0.0122 0.0614 0.153
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0174 0.1164 0.1421
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0223 0.1688 0.1808
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0168 0.1104 0.1183
Schistosoma mansoni unc-13 (munc13) 0.0121 0.0595 0.0964
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0183 0.1263 0.3395
Echinococcus granulosus serine/threonine protein kinase 0.0168 0.1099 0.1099
Trypanosoma cruzi polo-like protein kinase, putative 0.0269 0.2187 0.6048
Echinococcus granulosus Vam6:Vps39 protein 0.0108 0.0463 0.0463
Brugia malayi Protein kinase domain containing protein 0.0166 0.1084 0.1162
Leishmania major protein kinase, putative 0.0141 0.0819 0.3263
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0121 0.0595 0.0726
Brugia malayi SH2 domain containing protein 0.0415 0.3747 0.4015
Echinococcus multilocularis casein kinase I delta 0.0113 0.0508 0.062
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0115 0.0187
Trichomonas vaginalis CMGC family protein kinase 0.0088 0.0249 0.0484
Brugia malayi Temporarily assigned gene name protein 59 0.0125 0.0642 0.0688
Giardia lamblia Kinase, AGC AKT 0.0121 0.0596 0.2445
Schistosoma mansoni vav2 0.0182 0.1257 0.2036
Echinococcus granulosus cGMP dependent protein kinase 1 0.0138 0.0778 0.0778
Echinococcus multilocularis neuroglian 0.0117 0.0558 0.0681
Brugia malayi hypothetical protein 0.0107 0.045 0.0483
Brugia malayi Variant SH3 domain containing protein 0.01 0.0378 0.0405
Trichomonas vaginalis CMGC family protein kinase 0.0088 0.0249 0.0484
Echinococcus granulosus calcium dependent protein kinase 0.0102 0.0399 0.0399
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0308 0.0653
Loa Loa (eye worm) AGC/PKA protein kinase 0.0117 0.0554 0.0593
Trichomonas vaginalis AGC family protein kinase 0.0381 0.338 0.9475
Echinococcus multilocularis nervana 2 0.012 0.0587 0.0717
Echinococcus multilocularis protein kinase c iota type 0.0442 0.4038 0.493
Trichomonas vaginalis CAMK family protein kinase 0.0119 0.0575 0.1419
Echinococcus multilocularis protein kinase c epsilon type 0.0641 0.6173 0.7535
Trichomonas vaginalis CMGC family protein kinase 0.0088 0.0249 0.0484
Brugia malayi Protein kinase domain containing protein 0.0289 0.24 0.2571
Entamoeba histolytica protein kinase, putative 0.0093 0.0304 0.064
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0089 0.0259 0.0512
Loa Loa (eye worm) casein kinase 0.0175 0.1175 0.1259
Brugia malayi Protein kinase domain containing protein 0.0098 0.0358 0.0384
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0148 0.0891 0.2326
Echinococcus granulosus dual specificity protein kinase clk2 0.0156 0.0975 0.0975
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0153 0.094 0.1148
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0141 0.0819 0.7904
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0564 0.5351 0.6533
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0242 0.1898 0.1898
Entamoeba histolytica protein kinase domain containing protein 0.0142 0.0823 0.2132
Echinococcus granulosus neuroglian 0.0117 0.0558 0.0558
Echinococcus granulosus rho-associated protein kinase 1 0.0322 0.2757 0.2757
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0249 0.1969 0.2403
Schistosoma mansoni serine/threonine protein kinase 0.0117 0.0554 0.0897
Schistosoma mansoni tyrosine kinase 0.0157 0.0984 0.1595
Leishmania major protein kinase, putative 0.0156 0.0975 0.3955
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0589 0.5612 0.6013
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0419 0.0973
Echinococcus granulosus serine:threonine protein kinase N2 0.0378 0.3349 0.3349
Trichomonas vaginalis CAMK family protein kinase 0.0269 0.2187 0.6048
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0638 0.614 0.658
Toxoplasma gondii AGC kinase 0.0117 0.0554 0.1085
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0212 0.1577 0.6613
Trichomonas vaginalis STE family protein kinase 0.0085 0.0211 0.0373
Echinococcus granulosus titin 0.0084 0.0198 0.0198
Trichomonas vaginalis CK1 family protein kinase 0.0113 0.0508 0.1228
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0212 0.1577 0.4534
Loa Loa (eye worm) hypothetical protein 0.0358 0.3141 0.3365
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0249 0.1969 0.2403
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0094 0.0308 0.0653
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0156 0.0975 0.1045
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0077 0.0129 0.0227
Echinococcus granulosus growth factor receptor bound protein 2 0.0104 0.0415 0.0415
Giardia lamblia Kinase, CMGC GSK 0.0132 0.0716 0.3017
Trypanosoma cruzi aurora B kinase, putative 0.0148 0.0891 0.2326
Echinococcus multilocularis serine:threonine protein kinase 38 0.0252 0.2003 0.2445
Schistosoma mansoni serine/threonine protein kinase 0.0488 0.4527 0.7334
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0129 0.0688 0.2687
Schistosoma mansoni protein kinase 0.0113 0.0508 0.0823
Onchocerca volvulus 0.0121 0.0596 0.0557
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0132 0.0716 0.1615
Trichomonas vaginalis CAMK family protein kinase 0.013 0.0692 0.1756
Entamoeba histolytica PH domain containing protein kinase, putative 0.0168 0.1099 0.2925
Brugia malayi casein kinase 1, delta 0.0113 0.0508 0.0545
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0156 0.0975 0.246
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0554 0.1358
Schistosoma mansoni tyrosine kinase 0.0447 0.409 0.6625
Loa Loa (eye worm) TK/FER protein kinase 0.0121 0.0596 0.0639
Toxoplasma gondii diacylglycerol kinase, putative 0.011 0.0477 0.0835
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0566 0.5365 0.8691
Echinococcus multilocularis 0.0117 0.0556 0.0679
Schistosoma mansoni tyrosine kinase 0.0403 0.3616 0.5858
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0089 0.0259 0.0512
Schistosoma mansoni serine/threonine kinase 0.0252 0.2003 0.3244
Entamoeba histolytica PH domain containing protein kinase, putative 0.0168 0.1099 0.2925
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0308 0.0499
Brugia malayi Temporarily assigned gene name protein 59 0.0108 0.0463 0.0496
Schistosoma mansoni protein kinase 0.0572 0.5432 0.8799
Brugia malayi cyclin-dependent kinase 7 homolog 0.0121 0.0604 0.0647
Echinococcus granulosus roundabout 2 0.0155 0.0964 0.0964
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0308 0.0653
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0098 0.0358 0.0384
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.0508 0.0823
Plasmodium falciparum casein kinase 2, alpha subunit 0.0104 0.0419 0.2526
Echinococcus granulosus tyrosine protein kinase ABL1 0.0322 0.275 0.275
Echinococcus granulosus hypothetical protein 0.0117 0.0556 0.0556
Trichomonas vaginalis CK1 family protein kinase 0.0113 0.0508 0.1228
Echinococcus granulosus serine:threonine protein kinase 0.0078 0.0143 0.0143
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0141 0.0819 0.7904
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0127 0.0661 0.0661
Trypanosoma brucei SNF1-related protein kinases, putative 0.0094 0.0308 0.069
Brugia malayi Protein kinase domain containing protein 0.0305 0.2569 0.2753
Schistosoma mansoni serine/threonine protein kinase 0.0117 0.0554 0.0897
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.043 0.3915 0.4196
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0284 0.2343 0.6856
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0164 0.1057 0.1132
Brugia malayi serine/threonine-protein kinase plk-2 0.0269 0.2187 0.2343
Echinococcus granulosus casein kinase ii subunit alpha 0.0104 0.0419 0.0419
Trichomonas vaginalis STE family protein kinase 0.0127 0.0661 0.1667
Brugia malayi Protein kinase domain containing protein 0.0218 0.1634 0.1751
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0308 0.0653
Leishmania major protein kinase, putative 0.0156 0.0975 0.3955
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0156 0.0975 0.2569
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0389 0.3474 0.3723
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0308 0.0499
Loa Loa (eye worm) hypothetical protein 0.0107 0.045 0.0483
Schistosoma mansoni protein kinase 0.0096 0.0329 0.0533
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0204 0.1484 0.159
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0141 0.0819 0.0819
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0141 0.0819 0.0877
Echinococcus granulosus mitogen activated protein kinase 0.0088 0.0249 0.0249
Entamoeba histolytica p21-activated kinase 0.0135 0.0754 0.1934
Loa Loa (eye worm) hypothetical protein 0.01 0.0378 0.0405
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0302 0.2538 0.7056
Onchocerca volvulus 0.0132 0.0716 0.0687
Leishmania major protein kinase A catalytic subunit isoform 2 0.0117 0.0554 0.209
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0419 0.0973
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0147 0.0883 0.1078
Brugia malayi Protein kinase domain containing protein 0.0589 0.5612 0.6013
Loa Loa (eye worm) AGC/NDR protein kinase 0.0252 0.2003 0.2146
Echinococcus granulosus serine:threonine protein kinase 3 0.0256 0.2047 0.2047
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0823 0.2132
Schistosoma mansoni tyrosine kinase 0.0471 0.4345 0.7039
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0141 0.0819 0.7904
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0089 0.0259 0.0512
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0308 0.0653
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0242 0.1898 0.2317
Loa Loa (eye worm) hypothetical protein 0.0358 0.3141 0.3365
Entamoeba histolytica serine/threonine protein kinase, putative 0.0269 0.2187 0.6048
Echinococcus multilocularis protein kinase c eta type 0.011 0.0477 0.0582
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0464 0.4274 0.4274
Loa Loa (eye worm) AUR protein kinase 0.0148 0.0891 0.0954
Schistosoma mansoni serine/threonine protein kinase 0.0322 0.2757 0.4466
Schistosoma mansoni diacylglycerol kinase theta 0.011 0.0477 0.0773
Loa Loa (eye worm) hypothetical protein 0.0108 0.0463 0.0496
Schistosoma mansoni serine/threonine protein kinase 0.0269 0.2187 0.3543
Echinococcus multilocularis serine:threonine protein kinase N2 0.052 0.488 0.5958
Brugia malayi Protein kinase domain containing protein 0.0067 0.0022 0.0024
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0398 0.3563 1
Onchocerca volvulus 0.0471 0.4348 0.4612
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0304 0.2561 0.3126
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0416 0.3755 0.3755
Giardia lamblia Kinase, STE STE20 0.0089 0.0259 0.0846
Brugia malayi Protein kinase domain containing protein 0.0166 0.1084 0.1162
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0148 0.0884 0.1079
Brugia malayi protein kinase C II. 0.0641 0.6173 0.6614
Giardia lamblia Kinase, AGC PKA 0.0159 0.1006 0.4395
Brugia malayi Tyrosine-protein kinase abl-1 0.0234 0.1808 0.1938
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0098 0.0358 0.0384
Schistosoma mansoni serine/threonine protein kinase 0.0564 0.5351 0.8669
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0424 0.3846 0.4121
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0089 0.0259 0.054
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0127 0.0661 0.0661
Trichomonas vaginalis CAMK family protein kinase 0.0119 0.0575 0.1419
Echinococcus multilocularis expressed protein 0.0088 0.0243 0.0296
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0142 0.0823 0.2132
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0073 0.0089 0.0023
Loa Loa (eye worm) hypothetical protein 0.0119 0.0573 0.0614
Loa Loa (eye worm) hypothetical protein 0.0069 0.0043 0.0046
Brugia malayi intracellular kinase 0.0132 0.0716 0.0767
Trichomonas vaginalis AGC family protein kinase 0.0148 0.0891 0.2326
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0363 0.3189 0.3893
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.0614 0.0994
Schistosoma mansoni serine/threonine protein kinase 0.0252 0.2003 0.3244
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0223 0.1688 0.1688
Entamoeba histolytica protein kinase, putative 0.0212 0.1577 0.4296
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0127 0.0664 0.1675
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0084 0.0201 0.0201
Brugia malayi Protein kinase domain containing protein 0.0447 0.409 0.4382
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0132 0.0716 0.2809
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0308 0.0653
Loa Loa (eye worm) hypothetical protein 0.0107 0.045 0.0483
Schistosoma mansoni protein kinase 0.0109 0.0468 0.0757
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0166 0.1084 0.1162
Brugia malayi Protein kinase domain containing protein 0.0078 0.0143 0.0154
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0269 0.2187 0.9311
Echinococcus granulosus casein kinase I gamma 0.0214 0.1594 0.1594
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0486 0.4515 0.4515
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.043 0.3915 0.4196
Echinococcus granulosus N chimaerin 0.0174 0.1164 0.1164
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0111 0.0488 0.0488
Brugia malayi Protein kinase domain containing protein 0.0442 0.4039 0.4328
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.0786 0.1274
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0416 0.3755 0.4584
Trichomonas vaginalis CAMK family protein kinase 0.0078 0.0143 0.018
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0116 0.0545 0.0666
Echinococcus granulosus Diacylglycerol kinase theta 0.011 0.0477 0.0477
Loa Loa (eye worm) TK protein kinase 0.0289 0.24 0.2571
Entamoeba histolytica protein kinase, putative 0.0093 0.0304 0.064
Brugia malayi Tyrosine-protein kinase abl-1 0.0124 0.0633 0.0678
Echinococcus granulosus Rac GTPase activating protein 1 0.011 0.0477 0.0477
Plasmodium vivax casein kinase 1, putative 0.0113 0.0508 0.4438
Loa Loa (eye worm) hypothetical protein 0.0115 0.0537 0.0576
Echinococcus multilocularis casein kinase I alpha 0.0113 0.0508 0.062
Brugia malayi serine/threonine kinase 12 0.0148 0.0891 0.0954
Loa Loa (eye worm) hypothetical protein 0.0175 0.1176 0.1261
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0088 0.0243 0.0465
Echinococcus granulosus cyclin dependent kinase 19 0.0166 0.1084 0.1084
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0349 0.3042 0.3713
Entamoeba histolytica protein kinase, putative 0.0148 0.0891 0.2326
Echinococcus granulosus defective proboscis extension response 0.009 0.0266 0.0266
Brugia malayi Variant SH3 domain containing protein 0.0084 0.02 0.0214
Entamoeba histolytica protein kinase, putative 0.0103 0.0409 0.0942
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.0891 0.1443
Echinococcus multilocularis tyrosine protein kinase Blk 0.0206 0.151 0.1843
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0096 0.0331 0.0404
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0078 0.0134 0.0164
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0235 0.1821 0.1951
Brugia malayi C1-like domain containing protein 0.0287 0.238 0.2551
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0084 0.0201 0.0245
Loa Loa (eye worm) TK/FER protein kinase 0.0121 0.0596 0.0639
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0076 0.0115 0.0141
Loa Loa (eye worm) hypothetical protein 0.0173 0.1157 0.124
Echinococcus granulosus tyrosine protein kinase Lyn 0.0281 0.2318 0.2318
Entamoeba histolytica protein kinase, putative 0.0076 0.0115 0.01
Schistosoma mansoni rap gtpase-activating protein 0.0108 0.0463 0.075
Echinococcus multilocularis casein kinase ii subunit alpha 0.0104 0.0419 0.0512
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.0312 0.0664
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0308 0.0653
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0269 0.2187 0.2343
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0188 0.1316 0.141
Entamoeba histolytica protein kinase, putative 0.0085 0.0211 0.0373
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0117 0.0554 0.1433
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.01 0.0378 0.0612
Trypanosoma cruzi casein kinase, putative 0.0113 0.0508 0.1228
Echinococcus multilocularis serine:threonine protein kinase 3 0.0256 0.2047 0.2499
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0398 0.3563 1
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0252 0.2003 0.2445
Echinococcus granulosus serine:threonine protein kinase N2 0.0126 0.0649 0.0649
Echinococcus granulosus Immunoglobulin 0.009 0.0266 0.0266
Giardia lamblia Kinase, CMGC CK2 0.0104 0.0419 0.1608
Echinococcus granulosus dual specificity 0.0142 0.0823 0.0823
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0094 0.0308 0.1006
Echinococcus granulosus activated cdc42 kinase 1 0.0218 0.1634 0.1634
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0572 0.5432 0.6631
Giardia lamblia Kinase, CAMK CAMKL 0.0102 0.039 0.147
Brugia malayi Fes/CIP4 homology domain containing protein 0.011 0.0479 0.0514
Echinococcus multilocularis tyrosine protein kinase 0.0289 0.24 0.2929
Echinococcus multilocularis basement membrane specific heparan sulfate 0.009 0.0266 0.0325
Trichomonas vaginalis CMGC family protein kinase 0.0156 0.0975 0.2569
Toxoplasma gondii histone kinase SNF1, putative 0.0094 0.0308 0.0284
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0403 0.3616 0.3616
Echinococcus multilocularis Immunoglobulin 0.009 0.0266 0.0325
Loa Loa (eye worm) variant SH3 domain-containing protein 0.01 0.0378 0.0405
Trichomonas vaginalis CAMK family protein kinase 0.0277 0.2269 0.6284
Echinococcus granulosus c-Jun N-terminal kinases 0.0488 0.4527 0.4527
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0138 0.0778 0.0949
Echinococcus multilocularis NCK adaptor protein 0.0104 0.0415 0.0507
Loa Loa (eye worm) hypothetical protein 0.0121 0.0596 0.0639
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0308 0.0653
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0094 0.0308 0.069
Loa Loa (eye worm) hypothetical protein 0.0088 0.0242 0.0259
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.009 0.0266 0.0431
Loa Loa (eye worm) SRC-1 0.0242 0.1898 0.2034
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0269 0.2187 0.2187
Trichomonas vaginalis STE family protein kinase 0.0127 0.0661 0.1667
Schistosoma mansoni tyrosine kinase 0.0105 0.0423 0.0685
Echinococcus granulosus tyrosine kinase 0.0121 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0117 0.0554 0.0593
Loa Loa (eye worm) hypothetical protein 0.011 0.0477 0.0511
Schistosoma mansoni nck2/grb4 0.01 0.0378 0.0612
Brugia malayi Ras association domain family 1 isoform A 0.011 0.0477 0.0511
Echinococcus granulosus NCK adaptor protein 0.01 0.0378 0.0378
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0094 0.0308 0.033
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0088 0.0249 0.0267
Echinococcus granulosus ephrin type A receptor 4 A 0.0185 0.128 0.128
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.0975 0.158
Entamoeba histolytica PH domain containing protein kinase, putative 0.0125 0.0646 0.1625
Echinococcus multilocularis activated cdc42 kinase 1 0.0218 0.1634 0.1994
Schistosoma mansoni tyrosine kinase 0.0242 0.1898 0.3075
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0247 0.1953 0.2093
Echinococcus multilocularis calcium activated potassium channel 0.0108 0.0463 0.0565
Brugia malayi Protein kinase domain containing protein 0.0121 0.0596 0.0639
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0308 0.0653
Echinococcus multilocularis c src tyrosine kinase 0.0157 0.0984 0.1202
Trichomonas vaginalis AGC family protein kinase 0.0148 0.0891 0.2326
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0148 0.0884 0.1079
Entamoeba histolytica diacylglycerol kinase, putative 0.011 0.0477 0.1138
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0116 0.0545 0.1334
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0081 0.0172 0.0185
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0334 0.2876 0.3511
Echinococcus multilocularis Rac GTPase activating protein 1 0.011 0.0477 0.0582
Plasmodium falciparum glycogen synthase kinase 3 0.0132 0.0716 0.6303
Giardia lamblia Kinase, CMGC DYRK 0.0142 0.0823 0.3525
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0083 0.0191 0.0204
Loa Loa (eye worm) hypothetical protein 0.0117 0.0556 0.0596
Trypanosoma cruzi casein kinase, putative 0.0113 0.0508 0.1228
Brugia malayi Protein kinase domain containing protein 0.0202 0.1465 0.157
Trichomonas vaginalis AGC family protein kinase 0.0381 0.338 0.9475
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0139 0.0794 0.7625
Loa Loa (eye worm) hypothetical protein 0.0537 0.5058 0.542
Toxoplasma gondii AGC kinase 0.0372 0.3287 1
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0252 0.2003 0.2146
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0415 0.3747 0.4575
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0156 0.0975 0.2712
Leishmania major casein kinase, putative 0.0113 0.0508 0.189
Brugia malayi ephrin receptor 1 precursor 0.0111 0.0491 0.0526
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0187 0.1309 0.1403
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0206 0.151 0.1843
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.1084 0.1756
Entamoeba histolytica casein kinase, putative 0.0104 0.0419 0.0973
Schistosoma mansoni tyrosine kinase 0.0242 0.1898 0.3075
Echinococcus multilocularis mitogen activated protein kinase 11 0.0284 0.2343 0.286
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0159 0.1006 0.2659
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0102 0.039 0.3122
Schistosoma mansoni protein kinase 0.0183 0.1263 0.2046
Echinococcus multilocularis rac serine:threonine kinase 0.0168 0.1099 0.1342
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.0884 0.1432
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0823 0.2132
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0096 0.0329 0.0752
Brugia malayi RhoGEF domain containing protein 0.011 0.0477 0.0511
Onchocerca volvulus 0.0322 0.2757 0.2893
Schistosoma mansoni serine/threonine protein kinase 0.0334 0.2876 0.466
Giardia lamblia Kinase, CMGC CLK 0.0156 0.0975 0.4248
Schistosoma mansoni protein kinase 0.0363 0.3189 0.5166
Loa Loa (eye worm) TK protein kinase 0.0351 0.3061 0.328
Plasmodium falciparum serine/threonine protein kinase 0.0088 0.0243 0.0277
Onchocerca volvulus 0.0121 0.0596 0.0557
Echinococcus multilocularis roundabout 2 0.0155 0.0964 0.1176
Echinococcus granulosus casein kinase I alpha 0.0113 0.0508 0.0508
Echinococcus granulosus unc 13 munc13 0.0121 0.0595 0.0595
Schistosoma mansoni protein kinase 0.0126 0.0655 0.1061
Schistosoma mansoni serine/threonine protein kinase 0.0378 0.3349 0.5426
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0334 0.2876 0.3082
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0117 0.0554 0.0593
Leishmania major protein kinase, putative 0.0148 0.0891 0.3581
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0117 0.0554 0.1358
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0287 0.238 0.2551
Echinococcus granulosus tyrosine protein kinase shark 0.0535 0.5031 0.5031
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0823 0.2132
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0148 0.0884 0.0884
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0212 0.1577 0.1689
Echinococcus granulosus epidermal growth factor receptor 0.0403 0.3616 0.3616
Entamoeba histolytica PH domain containing protein kinase, putative 0.0316 0.2692 0.75
Plasmodium falciparum protein kinase, putative 0.0096 0.0329 0.1371
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0138 0.0782 0.1266
Loa Loa (eye worm) hypothetical protein 0.0138 0.078 0.0835
Loa Loa (eye worm) TK/FER protein kinase 0.0121 0.0596 0.0639
Entamoeba histolytica protein kinase , putative 0.0148 0.0891 0.2326
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0122 0.0614 0.2356
Toxoplasma gondii aurora kinase 0.0148 0.0891 0.2184
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0349 0.3042 0.3259
Echinococcus granulosus mitogen activated protein kinase 14 0.0284 0.2343 0.2343
Loa Loa (eye worm) hypothetical protein 0.009 0.027 0.0289
Loa Loa (eye worm) hypothetical protein 0.0257 0.2054 0.2201
Entamoeba histolytica protein kinase, putative 0.0132 0.0716 0.1825
Trichomonas vaginalis STE family protein kinase 0.0089 0.0259 0.0512
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0126 0.0655 0.0702
Entamoeba histolytica cell division protein kinase 2, putative 0.013 0.0696 0.1766
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0156 0.0975 0.2569
Giardia lamblia Kinase, CDC7 0.0094 0.0312 0.1098
Loa Loa (eye worm) hypothetical protein 0.011 0.0477 0.0511
Onchocerca volvulus 0.0115 0.0537 0.0494
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0308 0.0499
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0521 0.0845
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0174 0.1164 0.1164
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0389 0.3474 0.4241
Schistosoma mansoni cyclin B 0.0073 0.0081 0.0131
Loa Loa (eye worm) hypothetical protein 0.0223 0.1689 0.181
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0308 0.0653
Schistosoma mansoni hypothetical protein 0.0069 0.0043 0.007
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0117 0.0554 0.1358
Loa Loa (eye worm) hypothetical protein 0.0116 0.0545 0.0584
Entamoeba histolytica casein kinase 1, putative 0.0113 0.0508 0.1228
Loa Loa (eye worm) TK/FER protein kinase 0.0121 0.0596 0.0639
Onchocerca volvulus Serine\/threonine kinase homolog 0.0166 0.1084 0.1084
Onchocerca volvulus 0.0936 0.9332 1
Echinococcus granulosus casein kinase I delta 0.0113 0.0508 0.0508
Brugia malayi casein kinase I 0.0113 0.0508 0.0545
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.0778 0.126
Echinococcus multilocularis mitogen activated protein kinase 14 0.0284 0.2343 0.286
Brugia malayi Protein kinase domain 0.0127 0.0661 0.0708
Plasmodium falciparum serine/threonine protein kinase KIN 0.0094 0.0308 0.111
Loa Loa (eye worm) AGC/PKG protein kinase 0.0138 0.0778 0.0833
Plasmodium vivax calcium-dependent protein kinase, putative 0.0141 0.0819 0.7904
Plasmodium falciparum calcium-dependent protein kinase 4 0.0141 0.0819 0.761
Echinococcus granulosus epidermal growth factor receptor 0.0604 0.5778 0.5778
Brugia malayi cell division control protein 2 homolog 0.0122 0.0614 0.0658
Schistosoma mansoni serine/threonine kinase 0.0196 0.1398 0.2265
Entamoeba histolytica hypothetical protein 0.011 0.0477 0.1138
Echinococcus multilocularis casein kinase I alpha 0.0113 0.0508 0.062
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0256 0.2047 0.2194
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0302 0.2538 0.7056
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0823 0.2132
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0151 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0107 0.045 0.0483
Leishmania major protein kinase A catalytic subunit 0.0117 0.0554 0.209
Giardia lamblia Kinase, NEK 0.0139 0.0794 0.3385
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0138 0.0778 0.1815
Echinococcus granulosus tyrosine protein kinase Blk 0.0206 0.151 0.151
Echinococcus granulosus cyclin dependent kinase 1 0.0122 0.0614 0.0614
Schistosoma mansoni diacylglycerol kinase theta 0.011 0.0477 0.0773
Trypanosoma brucei aurora B kinase 0.0148 0.0891 0.2455
Echinococcus granulosus aurora kinase A 0.0148 0.0891 0.0891
Brugia malayi Protein kinase domain containing protein 0.0214 0.1594 0.1709
Loa Loa (eye worm) TK/EPH protein kinase 0.0203 0.1483 0.1589
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0156 0.0975 0.2712
Echinococcus granulosus protein kinase c eta type 0.011 0.0477 0.0477
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0151 0.0923 0.0989
Loa Loa (eye worm) hypothetical protein 0.0161 0.1027 0.1101
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0117 0.0554 0.1358
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0187 0.1309 0.1403
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0398 0.3563 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0141 0.0819 0.0819
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.0172 0.0279
Loa Loa (eye worm) hypothetical protein 0.0118 0.057 0.0611
Schistosoma mansoni protein kinase C 0.0121 0.0595 0.0964
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0243 0.0393
Echinococcus granulosus cyclin dependent kinase 9 0.0083 0.0191 0.0191
Echinococcus multilocularis serine threonine protein kinase 0.0455 0.4177 0.5099
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0081 0.0172 0.0185
Entamoeba histolytica protein kinase, putative 0.0148 0.0891 0.2326
Echinococcus granulosus protein kinase c iota type 0.0442 0.4038 0.4038
Echinococcus multilocularis tyrosine protein kinase Abl 0.0234 0.1808 0.2207
Echinococcus multilocularis RNA directed DNA polymerase 0.0192 0.1359 0.1659
Trypanosoma brucei protein kinase, putative 0.0132 0.0716 0.1926
Echinococcus granulosus c src tyrosine kinase 0.0157 0.0984 0.0984
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0141 0.0819 0.0819
Trichomonas vaginalis CMGC family protein kinase 0.0132 0.0716 0.1825
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.1084 0.1756
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0141 0.0819 0.1949
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0572 0.5432 0.5432
Schistosoma mansoni cell adhesion molecule 0.0128 0.0672 0.1089
Echinococcus granulosus cyclin dependent kinase 7 0.0114 0.0521 0.0521
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0127 0.0661 0.0807
Echinococcus granulosus tyrosine kinase 0.0206 0.151 0.151
Loa Loa (eye worm) RasGEF domain-containing protein 0.011 0.0477 0.0511
Trichomonas vaginalis AGC family protein kinase 0.026 0.2085 0.5755
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0076 0.0115 0.0141
Schistosoma mansoni serine/threonine protein kinase 0.0252 0.2003 0.3244
Entamoeba histolytica protein kinase domain containing protein 0.0204 0.1484 0.4031
Brugia malayi Variant SH3 domain containing protein 0.01 0.0378 0.0405
Loa Loa (eye worm) TK/ABL protein kinase 0.0322 0.275 0.2947
Loa Loa (eye worm) hypothetical protein 0.0133 0.0733 0.0785
Echinococcus multilocularis 0.0168 0.1106 0.1351
Loa Loa (eye worm) hypothetical protein 0.0647 0.6232 0.6678
Giardia lamblia Kinase, STE STE20 0.0127 0.0661 0.2756
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0334 0.2876 0.2876
Plasmodium falciparum calcium-dependent protein kinase 3 0.0141 0.0819 0.761
Onchocerca volvulus 0.0084 0.0198 0.0126
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0234 0.1807 0.1936
Trichomonas vaginalis AGC family protein kinase 0.0381 0.338 0.9475
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0419 0.0973
Brugia malayi serine/threonine-protein kinase 6 0.0148 0.0891 0.0954
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0151 0.0923 0.0989
Loa Loa (eye worm) hypothetical protein 0.011 0.0477 0.0511
Trypanosoma cruzi casein kinase, putative 0.0113 0.0508 0.1228
Brugia malayi Protein kinase domain containing protein 0.0252 0.2003 0.2146
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0142 0.0823 0.225
Echinococcus granulosus Protein kinase C brain isozyme 0.0564 0.5351 0.5351
Onchocerca volvulus 0.0121 0.0596 0.0557
Echinococcus granulosus twitchin 0.0156 0.0977 0.0977
Brugia malayi Immunoglobulin I-set domain containing protein 0.0107 0.045 0.0483
Echinococcus multilocularis dual specificity 0.0142 0.0823 0.1005
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0249 0.0404
Loa Loa (eye worm) TK/FAK protein kinase 0.0305 0.2569 0.2753
Onchocerca volvulus 0.0108 0.0463 0.0413
Onchocerca volvulus 0.0248 0.1961 0.2032
Loa Loa (eye worm) hypothetical protein 0.0225 0.1712 0.1834
Echinococcus multilocularis aurora kinase A 0.0148 0.0891 0.1087
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0183 0.1263 0.5227
Echinococcus multilocularis CDC7 cell division cycle 7 0.0094 0.0312 0.0381
Loa Loa (eye worm) hypothetical protein 0.011 0.0477 0.0511
Echinococcus granulosus dual specificity mitogen activated protein 0.0183 0.1263 0.1263
Echinococcus multilocularis protein tyrosine kinase 0.0302 0.2538 0.3098
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0308 0.0499
Echinococcus multilocularis casein kinase I alpha 0.0113 0.0508 0.062
Schistosoma mansoni serine/threonine protein kinase 0.0254 0.2028 0.3286
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0127 0.0664 0.1675
Echinococcus multilocularis serine:threonine protein kinase 0.0078 0.0143 0.0175
Loa Loa (eye worm) CAMK protein kinase 0.0084 0.0198 0.0212
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0349 0.3042 0.3259
Trichomonas vaginalis AGC family protein kinase 0.0148 0.0891 0.2326
Giardia lamblia Kinase, CMGC CDK 0.0122 0.0614 0.253
Echinococcus multilocularis expressed conserved protein 0.0138 0.0778 0.0949
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0226 0.0366
Schistosoma mansoni protein kinase 0.0572 0.5432 0.8799
Brugia malayi probable protein kinase 0.0264 0.2131 0.2284
Brugia malayi Casein kinase II, alpha chain 0.0104 0.0419 0.0449
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0104 0.0419 0.3447
Schistosoma mansoni pyruvate dehydrogenase 0.0116 0.0545 0.0884
Echinococcus granulosus cGMP dependent protein kinase 1 0.0138 0.0778 0.0778
Echinococcus multilocularis tyrosine protein kinase Srms 0.0206 0.151 0.1843
Brugia malayi Protein kinase domain containing protein 0.0936 0.9332 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0269 0.2187 0.2277
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0108 0.0463 0.1098
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0081 0.0172 0.0264
Brugia malayi Fibronectin type III domain containing protein 0.0107 0.045 0.0483
Schistosoma mansoni protein kinase C mu 0.011 0.0477 0.0773
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0122 0.0614 0.0614
Loa Loa (eye worm) thyroid receptor interactor 0.011 0.0479 0.0514
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0127 0.0664 0.1675
Trichomonas vaginalis AGC family protein kinase 0.0252 0.2003 0.5519
Trypanosoma cruzi Protein kinase B 0.0168 0.1099 0.2925
Brugia malayi serine/threonine-protein kinase PAK 7 0.0247 0.1953 0.2093
Brugia malayi Protein kinase domain containing protein 0.0349 0.3042 0.3259
Loa Loa (eye worm) TK/FER protein kinase 0.0121 0.0596 0.0639
Echinococcus multilocularis rho associated protein kinase 0.0322 0.2757 0.3365
Echinococcus multilocularis epidermal growth factor receptor 0.0403 0.3616 0.4414
Schistosoma mansoni protein kinase 0.0264 0.2131 0.3452
Echinococcus multilocularis calcium dependent protein kinase 0.0102 0.0399 0.0487
Brugia malayi p70 ribosomal S6 kinase beta 0.0372 0.3287 0.3522
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0122 0.0614 0.0658
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0363 0.3189 0.3189
Echinococcus granulosus raf serine:threonine protein kinase 0.0166 0.1084 0.1084
Trichomonas vaginalis CAMK family protein kinase 0.0269 0.2187 0.6048
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0122 0.0614 0.0658
Echinococcus multilocularis growth factor receptor bound protein 2 0.01 0.0378 0.0461
Brugia malayi SRC-1 0.0242 0.1898 0.2034
Leishmania major protein kinase, putative 0.0096 0.0329 0.1096
Echinococcus granulosus casein kinase I alpha 0.0113 0.0508 0.0508
Schistosoma mansoni tyrosine kinase 0.0383 0.3404 0.5515
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0566 0.5365 0.6549
Brugia malayi Immunoglobulin I-set domain containing protein 0.0638 0.614 0.658
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0151 0.0923 0.1127
Plasmodium falciparum calcium-dependent protein kinase 2 0.0141 0.0819 0.761
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0117 0.0554 0.0676
Loa Loa (eye worm) hypothetical protein 0.0173 0.1157 0.124
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0463 0.075
Schistosoma mansoni atypical protein kinase C 0.0448 0.4102 0.6645
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0223 0.1689 0.1689
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0202 0.1464 0.1788
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0242 0.1896 0.2032
Giardia lamblia Kinase, CAMK CAMKL 0.0102 0.039 0.147
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0194 0.1382 0.1481
Echinococcus granulosus tyrosine protein kinase Fyn 0.0242 0.1898 0.1898
Plasmodium falciparum calcium-dependent protein kinase 5 0.0141 0.0819 0.761
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0117 0.0554 0.1433
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0308 0.0653
Brugia malayi hypothetical protein 0.0121 0.0596 0.0639
Schistosoma mansoni protein kinase 0.0246 0.1944 0.3149
Onchocerca volvulus 0.0113 0.0508 0.0462
Echinococcus granulosus insulin receptor 0.0447 0.409 0.409
Brugia malayi Protein kinase domain containing protein 0.0122 0.0614 0.0658
Onchocerca volvulus 0.0537 0.5058 0.538
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0398 0.3563 1
Brugia malayi MAP kinase sur-1 0.0088 0.0249 0.0267
Echinococcus granulosus protein kinase C gamma type 0.0455 0.4177 0.4177

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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