Detailed information for compound 1442508

Basic information

Technical information
  • TDR Targets ID: 1442508
  • Name: 8-(furan-2-ylmethylamino)-1,3-dimethyl-7-[(E) -3-phenylprop-2-enyl]purine-2,6-dione
  • MW: 391.423 | Formula: C21H21N5O3
  • H donors: 1 H acceptors: 3 LogP: 2.72 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1c(=O)n(C)c2c(c1=O)n(C/C=C/c1ccccc1)c(n2)NCc1ccco1
  • InChi: 1S/C21H21N5O3/c1-24-18-17(19(27)25(2)21(24)28)26(12-6-10-15-8-4-3-5-9-15)20(23-18)22-14-16-11-7-13-29-16/h3-11,13H,12,14H2,1-2H3,(H,22,23)/b10-6+
  • InChiKey: JODZPCBJSRWBIJ-UXBLZVDNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-(furan-2-ylmethylamino)-1,3-dimethyl-7-(3-phenylprop-2-enyl)purine-2,6-dione
  • 8-(2-furylmethylamino)-1,3-dimethyl-7-[(E)-3-phenylprop-2-enyl]purine-2,6-dione
  • 8-(2-furylmethylamino)-1,3-dimethyl-7-(3-phenylprop-2-enyl)purine-2,6-dione
  • 8-(2-furylmethylamino)-1,3-dimethyl-7-(3-phenylprop-2-enyl)xanthine
  • 8-(2-furylmethylamino)-1,3-dimethyl-7-[(E)-3-phenylprop-2-enyl]xanthine
  • ZINC02426268
  • MLS000042269
  • SMR000045669

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Proteasome A-type and B-type family protein 0.0326 0.3221 0.7148
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0037 0.0222 0.0219
Entamoeba histolytica hypothetical protein 0.0043 0.0284 0.0613
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.002 0.0036 0.0074
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0149 0.0312
Trypanosoma brucei protease regulatory ATPase subunit 4 0.0017 0.0009 0.002
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0018 0.0025 0.005
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0075 0.0073
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0131 0.1198 0.2646
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0284 0.0282
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0122 0.1101 0.2445
Echinococcus multilocularis lamin 0.0033 0.0171 0.0169
Brugia malayi hypothetical protein 0.0043 0.0284 0.0613
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0026 0.0104 0.0226
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0014
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0133 0.1217 0.2689
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0026 0.0105 0.0215
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0122 0.1101 0.2431
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0132 0.1202 0.2656
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0033 0.0179 0.0398
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0151 0.1398 0.3091
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0028 0.0129 0.0285
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0132 0.1202 0.2667
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0151 0.1398 0.3101
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0125 0.1135 0.2518
Toxoplasma gondii proteasome beta subunit 0.0127 0.115 0.254
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0026 0.0105 0.0215
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0131 0.1198 0.2657
Plasmodium vivax proteasome subunit beta type-3, putative 0.0127 0.115 0.254
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0127 0.115 0.2551
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0075 0.0162
Schistosoma mansoni 26S proteasome subunit S9 0.0031 0.016 0.0336
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0075 0.0162
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0127 0.115 0.1148
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0082 0.0681 0.1497
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0075 0.0162
Schistosoma mansoni proteasome regulatory subunit-related 0.0029 0.013 0.0269
Entamoeba histolytica proteasome regulatory subunit, putative 0.0018 0.0024 0.0034
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0029 0.013 0.0269
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0127 0.115 0.254
Schistosoma mansoni hypothetical protein 0.0043 0.0284 0.0613
Echinococcus granulosus intermediate filament protein 0.0033 0.0171 0.0375
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0175 0.1645 0.365
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0228 0.0501
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0018 0.0025 0.0036
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0136 0.1247 0.2756
Toxoplasma gondii proteasome subunit 0.0132 0.1206 0.2665
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0092 0.0198
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0029 0.013 0.0283
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0026 0.0105 0.0215
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0132 0.1202 0.2656
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0017 0.0014 0.0026
Plasmodium vivax proteasome subunit beta type-1, putative 0.0151 0.1398 0.3091
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0075 0.0167
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0018 0.0025 0.0036
Loa Loa (eye worm) proteasome 26S subunit 0.0017 0.0009 0.0014
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0017 0.0014 0.0026
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0128 0.1159 0.2559
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.045 0.4502 1
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0186 0.1761 0.39
Giardia lamblia 20S proteasome alpha subunit 6 0.0131 0.1198 0.2657
Loa Loa (eye worm) hypothetical protein 0.0082 0.0681 0.1509
Toxoplasma gondii proteasome subunit alpha type, putative 0.0132 0.1202 0.2656
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0017 0.0014 0.0011
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0075 0.0162
Leishmania major proteasome alpha 7 subunit, putative 0.0133 0.1217 0.2699
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0132 0.1202 0.2656
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0132 0.1206 0.2665
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0018 0.0024 0.0022
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0151 0.1398 0.1396
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0132 0.1206 0.2675
Echinococcus granulosus proteasome subunit beta type 6 0.0132 0.1206 0.2675
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0136 0.1247 0.2756
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0018 0.0025 0.0055
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0033 0.0179 0.0379
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0018 0.0025 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0075 0.0167
Schistosoma mansoni intermediate filament proteins 0.0033 0.0171 0.0361
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0017 0.0014 0.0011
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0175 0.1645 0.1643
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0132 0.1202 0.2667
Trypanosoma brucei proteasome beta 6 subunit 0.0151 0.1398 0.3105
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0026 0.0105 0.0215
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0143 0.1313 0.2913
Giardia lamblia 20S proteasome alpha subunit 2 0.0136 0.1247 0.2766
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0142 0.1305 0.2884
Onchocerca volvulus 0.0017 0.0014 0.0037
Brugia malayi Ubiquitin interaction motif family protein 0.0018 0.0024 0.0034
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0104 0.0912 0.2025
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0151 0.1398 0.3101
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0143 0.1313 0.2917
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0125 0.1135 0.2518
Trichomonas vaginalis 26S proteasome subunit, putative 0.0026 0.0104 0.0226
Leishmania major proteasome beta 2 subunit, putative 0.0127 0.115 0.2551
Loa Loa (eye worm) RPN-3 protein 0.0034 0.0184 0.0405
Brugia malayi hypothetical protein 0.003 0.0149 0.0312
Loa Loa (eye worm) hypothetical protein 0.0148 0.1369 0.3037
Trypanosoma cruzi serine peptidase, Clan SJ, family S16, putative 0.0017 0.0009 0.0014
Entamoeba histolytica proteasome regulatory subunit, putative 0.0029 0.013 0.0269
Mycobacterium ulcerans proteasome PrcA 0.0104 0.0912 0.189
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0075 0.0167
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0017 0.0014 0.0031
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0031 0.016 0.0158
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0017 0.0014 0.0026
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0133 0.1217 0.2689
Leishmania major proteasome alpha 2 subunit, putative 0.0136 0.1247 0.2766
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0127 0.115 0.254
Echinococcus granulosus proteasome subunit beta type 7 0.0326 0.3221 0.7153
Leishmania major proteasome beta 5 subunit, putative 0.045 0.4502 1
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0026 0.0105 0.0215
Loa Loa (eye worm) hypothetical protein 0.0186 0.1761 0.3909
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.133 0.295
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0018 0.0025 0.005
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0151 0.1398 0.3101
Trypanosoma brucei proteasome beta 7 subunit 0.0125 0.1135 0.2522
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0143 0.1313 0.2903
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0284 0.0613
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0142 0.1305 0.2894
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0031 0.016 0.0336
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0037 0.0222 0.0488
Toxoplasma gondii heat shock protein hslv, putative 0.0104 0.0912 0.201
Loa Loa (eye worm) proteasome regulatory particle 0.0031 0.016 0.035
Onchocerca volvulus Notchless protein homolog 0.0133 0.1217 0.8881
Giardia lamblia 20S proteasome alpha subunit 3 0.0132 0.1202 0.2667
Leishmania major hypothetical protein, conserved 0.003 0.0149 0.0326
Echinococcus granulosus adhesion regulating molecule 1 0.0082 0.0681 0.1509
Brugia malayi proteasome subunit alpha type 3 0.0133 0.1217 0.2689
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0175 0.1645 0.365
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0017 0.0014 0.0011
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0075 0.0167
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0136 0.1247 0.2756
Loa Loa (eye worm) PCI domain-containing protein 0.0026 0.0104 0.0226
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0034 0.0184 0.0405
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0127 0.115 0.2551
Echinococcus granulosus lamin 0.0033 0.0171 0.0375
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0037 0.0222 0.0488
Brugia malayi proteasome subunit beta type 2 0.0127 0.115 0.254
Echinococcus granulosus subfamily T1A non peptidase ue 0.0142 0.1305 0.2894
Echinococcus granulosus tumor protein p63 0.0408 0.407 0.9038
Loa Loa (eye worm) hypothetical protein 0.0025 0.0092 0.0198
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0037 0.0222 0.0474
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0149 0.0331
Onchocerca volvulus 0.0033 0.0171 0.1194
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0132 0.1206 0.2665
Echinococcus multilocularis 26S protease regulatory subunit 8 0.0017 0.0009 0.0007
Brugia malayi proteasome subunit alpha type 1 0.0131 0.1198 0.2646
Entamoeba histolytica hypothetical protein 0.0043 0.0284 0.0613
Brugia malayi hypothetical protein 0.0148 0.1369 0.3027
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0034 0.0184 0.0391
Brugia malayi Proteasome subunit alpha type 1 0.0117 0.1052 0.2321
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0175 0.1645 0.1643
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0033 0.0179 0.0379
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0127 0.115 0.254
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0326 0.3221 0.7148
Plasmodium vivax proteasome subunit beta type-6, putative 0.0132 0.1206 0.2665
Leishmania major 26S protease regulatory subunit, putative,serine peptidase, Clan SJ, family S16, putative 0.0017 0.0009 0.0014
Trypanosoma cruzi 20S proteasome subunit 0.0127 0.115 0.2551
Giardia lamblia 26S protease regulatory subunit 6A 0.0018 0.0025 0.005
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0025 0.005
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0136 0.1247 0.2766
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0025 0.0092 0.0184
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0132 0.1206 0.2665
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0127 0.115 0.254
Mycobacterium ulcerans proteasome PrcB 0.045 0.4502 1
Entamoeba histolytica proteasome regulatory subunit, putative 0.0031 0.016 0.0336
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0026 0.0105 0.0229
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0028 0.0129 0.0126
Echinococcus granulosus 26s protease regulatory subunit s10b 0.0017 0.0009 0.0014
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0131 0.1198 0.1196
Onchocerca volvulus 0.0017 0.0014 0.0037
Echinococcus granulosus Proteasome subunit alpha type 7 0.0175 0.1645 0.365
Brugia malayi 20S proteasome alpha5 subunit 0.0142 0.1305 0.2884
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0142 0.1305 0.2894
Toxoplasma gondii PCI domain-containing protein 0.0031 0.016 0.0336
Giardia lamblia Proteasome subunit beta type 3 0.0127 0.115 0.2551
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0171 0.0375
Toxoplasma gondii SAC3/GANP family protein 0.0025 0.0092 0.0184
Brugia malayi PCI domain containing protein 0.0029 0.013 0.0269
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.133 0.295
Loa Loa (eye worm) PAS-3 protein 0.0118 0.1056 0.2342
Brugia malayi Proteasome/cyclosome repeat family protein 0.0028 0.0121 0.025
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0028 0.0129 0.0281
Toxoplasma gondii proteasome subunit alpha1, putative 0.0143 0.1313 0.2903
Leishmania major proteasome beta 2 subunit, putative 0.0122 0.1101 0.2442
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0031 0.016 0.0336
Loa Loa (eye worm) PCI domain-containing protein 0.0029 0.013 0.0283
Echinococcus granulosus lamin dm0 0.0033 0.0171 0.0375
Entamoeba histolytica proteasome regulatory subunit, putative 0.0034 0.0184 0.0391
Onchocerca volvulus Huntingtin homolog 0.0148 0.1369 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0075 0.0167
Leishmania major proteasome regulatory ATPase subunit 0.0017 0.0009 0.0014
Trypanosoma brucei proteasome subunit beta type-5, putative 0.045 0.4502 1
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0104 0.0912 0.201
Echinococcus multilocularis proteasome subunit alpha type 6 0.0143 0.1313 0.1311
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0142 0.1305 0.2898
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0014 0.0027
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0026 0.0105 0.0229
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0037 0.0222 0.0488
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0136 0.1247 0.2766
Echinococcus multilocularis proteasome subunit alpha type 2 0.0136 0.1247 0.1245
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0394 0.0871
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0017 0.0014 0.0012
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0028 0.0129 0.0281
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0017 0.0014 0.0026
Echinococcus multilocularis proteasome (prosome, macropain) 0.045 0.4502 0.4501
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0149 0.0312
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0034 0.0184 0.0391
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0133 0.1217 0.2689
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0122 0.1101 0.2442
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0018 0.0025 0.0036
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0132 0.1202 0.2656
Giardia lamblia 20S proteasome alpha subunit 7 0.0133 0.1217 0.2699
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0105 0.0215
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0017 0.0014 0.0011
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0125 0.1135 0.2518
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0142 0.1305 0.2884
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0125 0.1135 0.1133
Echinococcus granulosus proteasome prosome macropain 0.045 0.4502 1
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0131 0.1198 0.2657
Loa Loa (eye worm) hypothetical protein 0.0025 0.0092 0.0198
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0175 0.1645 0.3641
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0133 0.1217 0.2689
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0142 0.1305 0.2894
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0026 0.0105 0.0234
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0142 0.1305 0.2884
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0026 0.0105 0.0229
Toxoplasma gondii hypothetical protein 0.0023 0.0072 0.014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0026
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0438 0.0955
Brugia malayi Proteasome A-type and B-type family protein 0.0132 0.1206 0.2665
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0026 0.0105 0.0215
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0017 0.0014 0.0026
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0133 0.1217 0.2699
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0075 0.0167
Loa Loa (eye worm) hypothetical protein 0.0033 0.0171 0.0375
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0082 0.0681 0.1497
Brugia malayi Probable 26S protease regulatory subunit 4 0.0017 0.0014 0.0011
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0026 0.0105 0.0215
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0018 0.0025 0.0036
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0034 0.0184 0.041
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0142 0.1305 0.2884
Loa Loa (eye worm) hypothetical protein 0.0148 0.1369 0.3037
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0133 0.1217 0.2689
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0017 0.0014 0.0031
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0037 0.0222 0.0488
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0131 0.1198 0.2646
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0127 0.115 0.2551
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0033 0.0179 0.0177
Giardia lamblia Proteasome subunit beta type 5 precursor 0.045 0.4502 1
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0104 0.0912 0.2021
Plasmodium vivax proteasome subunit beta type-2, putative 0.0127 0.115 0.254
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0026 0.0105 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0075 0.0167
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0028 0.0129 0.0266
Brugia malayi hypothetical protein 0.002 0.0037 0.0063
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0029 0.013 0.0269
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0122 0.1101 0.2431
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0125 0.1135 0.2518
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0075 0.0162
Onchocerca volvulus 0.006 0.0453 0.3267
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0026 0.0104 0.0231
Trypanosoma brucei unspecified product 0.0023 0.0075 0.0167
Entamoeba histolytica hypothetical protein 0.0033 0.0179 0.0379
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0175 0.1645 0.365
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0127 0.115 0.2551
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0034 0.0184 0.0182
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0127 0.115 0.2555
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0127 0.115 0.2551
Entamoeba histolytica hypothetical protein 0.0043 0.0284 0.0613
Loa Loa (eye worm) hypothetical protein 0.006 0.0453 0.1002
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0076 0.0619 0.0617
Brugia malayi proteasome subunit alpha type 2 0.0136 0.1247 0.2756
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0017 0.0009 0.0014
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0017 0.0014 0.0026
Schistosoma mansoni multiubiquitin binding protein S5a 0.0018 0.0024 0.0034
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0151 0.1398 0.3091
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0132 0.1202 0.2667
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0122 0.1101 0.2442
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0037 0.0222 0.0488
Entamoeba histolytica proteasome regulatory subunit, putative 0.0026 0.0104 0.0212
Leishmania major DNA polymerase eta, putative 0.0038 0.0228 0.0501
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0132 0.1206 0.2675
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0075 0.0148
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0149 0.0312
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0017 0.0014 0.0011
Schistosoma mansoni DNA polymerase eta 0.0054 0.0394 0.0858
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0017 0.0014 0.0026
Loa Loa (eye worm) 26S protease regulatory subunit 8 0.0017 0.0009 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0075 0.0167
Schistosoma mansoni lamin 0.0033 0.0171 0.0361
Leishmania major DNA polymerase kappa, putative 0.0023 0.0075 0.0162
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0133 0.1217 0.2699
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0026 0.0104 0.0226
Giardia lamblia 26S protease regulatory subunit 6B 0.0017 0.0014 0.0026
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0149 0.0312
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0028 0.0129 0.0266
Brugia malayi 26S protease regulatory subunit 6A 0.0018 0.0025 0.0036
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0075 0.0167
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0017 0.0014 0.0026
Leishmania major proteasome alpha 7 subunit, putative 0.0175 0.1645 0.365
Giardia lamblia DINP protein human, muc B family 0.0023 0.0075 0.0162
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0037 0.0222 0.0474
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0026 0.0104 0.0226
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0127 0.115 0.254
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0075 0.0167
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0394 0.0858
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0075 0.0148
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0029 0.013 0.0283
Echinococcus granulosus dna polymerase eta 0.0054 0.0394 0.0871
Leishmania major proteasome beta 3 subunit, putative 0.0127 0.115 0.2551
Entamoeba histolytica proteasome regulatory subunit, putative 0.0025 0.0092 0.0184
Trypanosoma brucei Regulatory particle triple-A ATPase subunit 6 0.0017 0.0009 0.002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0075 0.0162
Brugia malayi proteasome subunit alpha type 4 0.0118 0.1056 0.2331
Schistosoma mansoni hypothetical protein 0.0076 0.0619 0.1357
Loa Loa (eye worm) proteasome Regulatory Particle 0.0028 0.0129 0.0281
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0026 0.0105 0.0229
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0075 0.0167
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0132 0.1206 0.2675
Mycobacterium leprae proteasome (beta subunit) PrcB 0.045 0.4502 1
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.045 0.4502 1
Echinococcus granulosus proteasome subunit alpha type 2 0.0136 0.1247 0.2766
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0026 0.0105 0.0229
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0175 0.1645 0.1643
Echinococcus granulosus Proteasome subunit alpha beta 0.0133 0.1217 0.2699
Leishmania major proteasome alpha 3 subunit, putative 0.0132 0.1202 0.2667
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0127 0.115 0.254
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0131 0.1198 0.2657
Echinococcus granulosus dna polymerase kappa 0.0023 0.0075 0.0162
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0018 0.0025 0.0036
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0127 0.115 0.2551
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0031 0.016 0.0355
Loa Loa (eye worm) proteasome subunit beta type 1 0.0151 0.1398 0.3101
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0018 0.0025 0.0036
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0017 0.0014 0.0011
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0131 0.1198 0.2646
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0175 0.1645 0.365
Plasmodium vivax proteasome subunit beta type-4, putative 0.0125 0.1135 0.2507
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0018 0.0024 0.0049
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0029 0.013 0.0269
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0228 0.0487
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0122 0.1101 0.2442
Plasmodium vivax proteasome subunit beta type-7, putative 0.0122 0.1101 0.2431
Loa Loa (eye worm) hypothetical protein 0.0054 0.0394 0.0871
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0026 0.0105 0.0229
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0026 0.0104 0.0212
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.045 0.4502 1
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0453 0.0989
Toxoplasma gondii proteasome subunit alpha type, putative 0.0071 0.0566 0.1241
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.045 0.4502 1
Entamoeba histolytica hypothetical protein 0.0043 0.0284 0.0613
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0075 0.0167
Brugia malayi proteasome subunit beta type 3 0.0127 0.115 0.254
Toxoplasma gondii peptidase, T1 family protein 0.0133 0.1217 0.2689
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0026 0.0105 0.0215
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0025 0.0092 0.0184
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0018 0.0024 0.0049
Brugia malayi Proteasome A-type and B-type family protein 0.0125 0.1135 0.2507
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0029 0.013 0.0283
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0018 0.0019 0.0023
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0132 0.1202 0.12
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0025 0.0092 0.0198
Trypanosoma brucei proteasome alpha 7 subunit 0.0133 0.1217 0.2703
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0125 0.1135 0.2518
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0127 0.115 0.254
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0075 0.0148
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0175 0.1645 0.3641
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0125 0.1135 0.2518
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0026 0.0105 0.0229
Leishmania major DNA polymerase eta, putative 0.0054 0.0394 0.0871
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0025 0.0092 0.0184
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0127 0.115 0.2551
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0018 0.0019 0.0038
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0142 0.1305 0.2884
Toxoplasma gondii proteasome subunit beta type, putative 0.045 0.4502 1
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0034 0.0184 0.0391
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0133 0.1217 0.2699
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0018 0.0025 0.0022
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0142 0.1305 0.2894
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0082 0.0681 0.1497
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0026 0.0105 0.0215
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0104 0.0912 0.201
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0133 0.1217 0.2699
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0026 0.0105 0.0229
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0026 0.0105 0.0215
Onchocerca volvulus 0.0058 0.0438 0.3154
Brugia malayi Proteasome subunit alpha type 7-1 0.0175 0.1645 0.3641
Echinococcus granulosus 26S protease regulatory subunit 8 0.0017 0.0009 0.0014
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.045 0.4502 1
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0136 0.1247 0.2756
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0017 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0286 0.2798 0.6212
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0017 0.0014 0.0011
Leishmania major proteasome beta-1 subunit, putative 0.0132 0.1206 0.2675
Schistosoma mansoni lamin 0.0033 0.0171 0.0361
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0075 0.0148
Loa Loa (eye worm) hypothetical protein 0.003 0.0149 0.0326
Echinococcus multilocularis proteasome subunit beta type 6 0.0132 0.1206 0.1204
Brugia malayi intermediate filament protein 0.0033 0.0171 0.0361
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0025 0.0092 0.0089
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0017 0.0014 0.0011
Loa Loa (eye worm) RPT-2 protein 0.0017 0.0014 0.0026
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0025 0.0096 0.0209
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0028 0.0121 0.0264
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.045 0.4502 1
Giardia lamblia 20S proteasome alpha subunit 1 0.0143 0.1313 0.2913
Giardia lamblia 20S proteasome alpha subunit 5 0.0142 0.1305 0.2894
Giardia lamblia Proteasome subunit beta type 2 0.0127 0.115 0.2551
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0037 0.0222 0.0474
Giardia lamblia 20S proteasome alpha subunit 4 0.0175 0.1645 0.365
Toxoplasma gondii PCI domain-containing protein 0.0026 0.0104 0.0212
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0131 0.1198 0.2646
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0017 0.0014 0.0012
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0014 0.0012
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0104 0.0912 0.2021
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0031 0.016 0.035
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0034 0.0184 0.0405
Giardia lamblia 26S proteasome regulatory subunit, putative 0.002 0.0036 0.0074
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0017 0.0014 0.0026
Loa Loa (eye worm) hypothetical protein 0.0032 0.0165 0.0362
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0143 0.1313 0.2913
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0031 0.016 0.035
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0018 0.0024 0.0049
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0171 0.0375
Brugia malayi hypothetical protein 0.0286 0.2798 0.6207
Echinococcus multilocularis 26s protease regulatory subunit s10b 0.0017 0.0009 0.0007
Trypanosoma cruzi 26S protease regulatory subunit, putative 0.0017 0.0009 0.0014
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0018 0.0025 0.0036
Entamoeba histolytica proteasome regulatory subunit, putative 0.0028 0.0129 0.0266
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0034 0.0184 0.0405
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0031 0.016 0.035
Echinococcus granulosus proteasome subunit alpha type 6 0.0143 0.1313 0.2913
Echinococcus multilocularis adhesion regulating molecule 1 0.0082 0.0681 0.0679
Leishmania major proteasome alpha 1 subunit, putative 0.0131 0.1198 0.2657
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0125 0.1135 0.2518
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0143 0.1313 0.2903
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0149 0.0326
Schistosoma mansoni hypothetical protein 0.0058 0.0438 0.0955
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0104 0.0912 0.201
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2798 0.6212
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0142 0.1305 0.2894
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0122 0.1101 0.2442
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0028 0.0129 0.0266
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0017 0.0014 0.0011
Schistosoma mansoni survival motor neuron protein 0.0058 0.0438 0.0955
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0075 0.0073
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0171 0.0361
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0143 0.1313 0.2913
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0142 0.1305 0.2884
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0076 0.0619 0.137
Toxoplasma gondii proteasome regulatory subunit 0.0026 0.0105 0.0215
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0018 0.0024 0.0034
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0034 0.0184 0.0391
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0125 0.1135 0.2507
Brugia malayi Proteasome/cyclosome repeat family protein 0.0028 0.0121 0.025
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0028 0.0121 0.0264
Schistosoma mansoni 26S protease regulatory subunit 0.0017 0.0014 0.0011
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0028 0.0129 0.0266
Loa Loa (eye worm) proteasome subunit beta type 3 0.0127 0.115 0.2551
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0104 0.0912 0.189
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0028 0.0129 0.0281
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0075 0.0162
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0037 0.0222 0.0474
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0018 0.0025 0.005
Brugia malayi Proteasome A-type and B-type family protein 0.045 0.4502 1
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0029 0.013 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0075 0.0167
Leishmania major proteasome alpha 1 subunit, putative 0.0143 0.1313 0.2913
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0149 0.0326
Echinococcus multilocularis musashi 0.0033 0.0171 0.0169
Plasmodium falciparum proteasome subunit beta type-4 0.0125 0.1135 0.2507
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0018 0.0024 0.0049
Giardia lamblia Hypothetical protein 0.0031 0.016 0.035
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0132 0.1202 0.2656
Leishmania major hypothetical protein, conserved 0.0043 0.0275 0.0606
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0143 0.1313 0.2903
Schistosoma mansoni hypothetical protein 0.0026 0.0104 0.0212
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0037 0.0222 0.0488
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0136 0.1247 0.277
Giardia lamblia Proteasome subunit beta type 1 0.0151 0.1398 0.3101
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0122 0.1101 0.2431
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0127 0.115 0.254
Plasmodium vivax proteasome subunit beta type-5, putative 0.045 0.4502 1
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0175 0.1645 0.3641
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0125 0.1135 0.2507
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0142 0.1305 0.2884
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0092 0.0198
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0284 0.0626
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0132 0.1206 0.2675
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0151 0.1398 0.3101
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0142 0.1305 0.1303
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0033 0.0179 0.0379
Echinococcus granulosus proteasome subunit beta t family 0.0127 0.115 0.2551
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0017 0.0014 0.0026
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0026 0.0104 0.0226
Echinococcus multilocularis dna polymerase eta 0.0054 0.0394 0.0392
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0037 0.0222 0.0492
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0151 0.1398 0.3091
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0033 0.0179 0.0393
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0118 0.1058 0.2346
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0037 0.0222 0.0474
Echinococcus multilocularis proteasome subunit beta type 7 0.0326 0.3221 0.3219
Toxoplasma gondii PCI domain-containing protein 0.0034 0.0184 0.0391
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0131 0.1198 0.2657
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0018 0.0024 0.0049
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0127 0.115 0.254
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0151 0.1398 0.3091
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0104 0.0912 0.201
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0043 0.0275 0.0592
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0143 0.1313 0.2903
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0104 0.0912 0.5
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2798 0.2796
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0127 0.115 0.1148
Giardia lamblia 26S protease regulatory subunit 7 0.0017 0.0009 0.0014
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0017 0.0014 0.0026
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0122 0.1101 0.2442
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0037 0.0222 0.0474
Echinococcus multilocularis lamin dm0 0.0033 0.0171 0.0169
Loa Loa (eye worm) proteasome subunit beta type 2 0.0127 0.115 0.2551
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0132 0.1206 0.2675
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0025 0.0092 0.0203
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0025 0.0092 0.0184
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0052 0.0372 0.2668
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0151 0.1398 0.3101
Giardia lamblia 26S protease regulatory subunit 8 0.0017 0.0009 0.0014
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0018 0.0025 0.005
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0031 0.016 0.035
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0132 0.1206 0.2679
Brugia malayi 26S proteasome subunit P45 family protein 0.0017 0.0014 0.0011
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0122 0.1101 0.2442
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0125 0.1135 0.2518
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0026 0.0105 0.0229
Trypanosoma cruzi 19S proteasome regulatory subunit 0.0017 0.0009 0.0014
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0125 0.1135 0.2518
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0026 0.0104 0.0102
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0175 0.1645 0.3641
Schistosoma mansoni hypothetical protein 0.0186 0.1761 0.39
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0025 0.0092 0.0184
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0132 0.1202 0.2667
Loa Loa (eye worm) hypothetical protein 0.0023 0.0072 0.0154
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0394 0.0876
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0175 0.1645 0.3654
Leishmania major proteasome beta 7 subunit, putative 0.0125 0.1135 0.2518
Toxoplasma gondii proteasome 26S regulatory subunit 0.0018 0.0019 0.0023
Plasmodium falciparum proteasome subunit beta type-5 0.045 0.4502 1
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0016 0.0002 0.0005
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0143 0.1313 0.2913
Brugia malayi MH2 domain containing protein 0.0144 0.133 0.294
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0136 0.1247 0.2756
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0075 0.0162
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0092 0.0198
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0125 0.1135 0.2518
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0031 0.016 0.0336
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0125 0.1135 0.2507
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0127 0.115 0.2555
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0026 0.0104 0.0212
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.045 0.4502 1
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0133 0.1217 0.1215
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0075 0.0162
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0017 0.0014 0.0026
Onchocerca volvulus 0.0033 0.0171 0.1194
Brugia malayi PCI domain containing protein 0.0026 0.0104 0.0212
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0029 0.013 0.0288
Echinococcus multilocularis tumor protein p63 0.0408 0.407 0.4068
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0131 0.1198 0.266
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0025 0.0092 0.0198
Brugia malayi proteasome subunit alpha type 6 0.0143 0.1313 0.2903
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0104 0.0912 0.2021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0026
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0033 0.0179 0.0379
Onchocerca volvulus Huntingtin homolog 0.0148 0.1369 1
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0125 0.1135 0.2518
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0029 0.013 0.0283
Brugia malayi proteasome subunit beta type 1 0.0151 0.1398 0.3091
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0028 0.0129 0.0266
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0028 0.0129 0.0281
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0028 0.0129 0.0281
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0025 0.0092 0.0198
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0026 0.0105 0.0103
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0132 0.1202 0.267
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0131 0.1198 0.2646
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0175 0.1645 0.3641
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0016 0.0002 0.0005

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 4.38 uM PUBCHEM_BIOASSAY: Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504586] ChEMBL. No reference
AC50 (functional) = 158.412 uM PUBCHEM_BIOASSAY: Viability counterscreen of potential LMP-1 inhibitors in HEK293 cell background Measured in Cell-Based System Using Plate Reader - 2122-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504586] ChEMBL. No reference
EC50 (binding) > 112.219 um PUBCHEM_BIOASSAY: Luminescence Biochemical Dose Response HTS to Identify Inhibitors of Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 1663 (Primary HTS), 1678 (Summary of Project)] ChEMBL. No reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 4.1095 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.6109 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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