Detailed information for compound 1486514

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 581.559 | Formula: C23H30F3N3O9S
  • H donors: 2 H acceptors: 7 LogP: -0.89 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(F)(F)F.COc1ccc(cc1)S(=O)(=O)N(C[C@H]1N[C@@]([C@@H]2[C@H]1C(=O)N(C2=O)C)(CC)C(=O)OC)CC
  • InChi: 1S/C21H29N3O7S.C2HF3O2/c1-6-21(20(27)31-5)17-16(18(25)23(3)19(17)26)15(22-21)12-24(7-2)32(28,29)14-10-8-13(30-4)9-11-14;3-2(4,5)1(6)7/h8-11,15-17,22H,6-7,12H2,1-5H3;(H,6,7)/t15-,16+,17-,21-;/m1./s1
  • InChiKey: UWVWBJOLVXXTDA-DZJQLZCXSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0046 0.041
Echinococcus granulosus NADH dehydrogenase 0.0066 0.033 0.0654
Echinococcus granulosus cathepsin L 0.0017 0.0031 0.0056
Loa Loa (eye worm) hypothetical protein 0.0366 0.2178 0.3253
Echinococcus granulosus aryl hydrocarbon receptor 0.0052 0.0246 0.0486
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0031 0.0233
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.028 0.0415
Onchocerca volvulus 0.1144 0.6969 0.971
Plasmodium vivax importin-beta 2, putative 0.0035 0.0138 0.1192
Mycobacterium ulcerans acyl carrier protein 0.0066 0.033 0.0507
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0025 0.0034
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0534 0.3214 0.5394
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0034 0.0159
Leishmania major d-xylulose reductase, putative 0.0041 0.0173 0.1377
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0034 0.0045
Onchocerca volvulus 0.0041 0.0173 0.0242
Echinococcus multilocularis microtubule associated protein 2 0.0683 0.413 0.4128
Onchocerca volvulus 0.0617 0.3725 0.519
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0063 0.0125
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0041
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0031 0.0061
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0066 0.0418
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0076 0.01
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0073 0.0372 0.0578
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0653 0.3947 0.6634
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1124
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0188 0.1621
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0202 0.02
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0066 0.033 0.3259
Schistosoma mansoni zinc binding dehydrogenase 0.0041 0.0173 0.0346
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0121 0.1113
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0046 0.041
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0204 0.1183 0.118
Loa Loa (eye worm) hypothetical protein 0.0021 0.0054 0.0077
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.01 0.0541 0.0873
Leishmania major quinone oxidoreductase, putative 0.0041 0.0173 0.1377
Loa Loa (eye worm) hypothetical protein 0.0041 0.0173 0.0255
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0306 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1124
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.002 0.0137
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0041 0.0173 0.026
Brugia malayi MH2 domain containing protein 0.0017 0.0025 0.0034
Toxoplasma gondii exonuclease III APE 0.0019 0.0038 0.0009
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0041 0.0173 0.1681
Loa Loa (eye worm) RNA binding protein 0.0062 0.0306 0.0453
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0173 0.3228
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0173 0.1495
Brugia malayi AMP-binding enzyme family protein 0.0202 0.1166 0.1545
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.009 0.076
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0036 0.0148 0.0196
Entamoeba histolytica Ran family GTPase 0.0026 0.0081 0.1147
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0396 0.3467
Mycobacterium ulcerans oxidoreductase FadB5 0.0041 0.0173 0.0242
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0081 0.0795
Echinococcus multilocularis smad 0.0017 0.0025 0.0023
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0034 0.0287
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0025 0.0034
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0025 0.0045
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0041 0.0177 0.0349
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0066 0.0061
Toxoplasma gondii type I fatty acid synthase 0.01 0.0541 0.1215
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0322 0.1905 0.2523
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0131 0.1124
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0185 0.1064 0.1482
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1124
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0077 0.0396 0.0787
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0164 0.0933 0.2157
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.1335 0.1993
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0077 0.0396 0.3467
Brugia malayi Phosphopantetheine attachment site family protein 0.0066 0.033 0.0437
Leishmania major hypothetical protein, conserved 0.0041 0.0177 0.1413
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1124
Trypanosoma cruzi cruzipain precursor, putative 0.0129 0.0716 0.7623
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0131 0.0257
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0034 0.0062
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0031 0.0041
Mycobacterium ulcerans polyketide synthase 0.0694 0.4197 0.7054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0344 0.3
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0011 0.0013
Trichomonas vaginalis rotamase, putative 0.0032 0.0122 0.1043
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0525 0.3161 0.53
Brugia malayi Cathepsin L-like precursor 0.0023 0.0063 0.0083
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0066 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0052 0.0246 0.0363
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0081 0.0157
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0121 0.0119
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0012 0.0009
Brugia malayi MH2 domain containing protein 0.0017 0.0025 0.0034
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0046 0.0283
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0054 0.0379
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0041 0.0173 0.1681
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0067 0.0336 0.0517
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0694 0.4197 0.7057
Leishmania major cathepsin L-like protease 0.0129 0.0716 0.6241
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0066 0.033 0.046
Schistosoma mansoni chromobox protein 0.0068 0.0344 0.0687
Schistosoma mansoni smad 0.0017 0.0025 0.0051
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0127 0.0168
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0164 0.0933 0.1864
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0025 0.0023
Echinococcus granulosus microtubule associated protein 2 0.0683 0.413 0.8248
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0173 0.1377
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0173 0.023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0336 0.0526
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0038 0.0328
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0012 0.0019
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0046 0.0064
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0067 0.0336 0.0517
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0063 0.0516
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0034 0.0068
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0041 0.0173 0.0252
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0424 0.2534 0.5996
Echinococcus granulosus cathepsin l1 0.0034 0.0131 0.0257
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0012 0.0019
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0031 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1124
Echinococcus multilocularis chromobox protein 1 0.0068 0.0344 0.0341
Echinococcus multilocularis ubiquitin specific protease 41 0.0077 0.0396 0.0394
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0041 0.0177 0.1629
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0066 0.0061
Mycobacterium leprae Polyketide synthase Pks13 0.0976 0.5937 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0095
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0041 0.0173 0.0242
Echinococcus multilocularis lamin dm0 0.0027 0.0088 0.0085
Entamoeba histolytica hypothetical protein 0.0036 0.0143 0.2535
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.016 0.0907 0.1492
Leishmania major oxidoreductase-like protein 0.0041 0.0173 0.1377
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0041 0.0173 0.0334
Leishmania major nuclear receptor binding factor-like protein 0.0041 0.0173 0.1377
Onchocerca volvulus 0.0034 0.0131 0.0183
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0331 0.1963 0.4626
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0633 0.3824 0.6426
Onchocerca volvulus Protein cycle homolog 0.0037 0.0149 0.0208
Brugia malayi Methyltransferase-like protein 4 0.0197 0.1136 0.1504
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0046 0.0283
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0066 0.0071
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0041 0.0173 0.0252
Brugia malayi hypothetical protein 0.0036 0.0148 0.0196
Leishmania major protein kinase, putative 0.002 0.0044 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Leishmania major acyl carrier protein, putative 0.0066 0.033 0.2779
Onchocerca volvulus 0.0034 0.0131 0.0183
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0041 0.0177 0.0175
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0034 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1124
Onchocerca volvulus 0.0034 0.0131 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1124
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0173 0.1681
Schistosoma mansoni lamin 0.0027 0.0088 0.0175
Mycobacterium ulcerans short-chain dehydrogenase 0.0044 0.0197 0.0282
Onchocerca volvulus 0.0027 0.0088 0.0122
Mycobacterium ulcerans fatty acid synthase Fas 0.0205 0.1187 0.1959
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0034 0.013
Entamoeba histolytica acyl-CoA synthetase, putative 0.0089 0.0473 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0148 0.0217
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1124
Leishmania major cathepsin L-like protease 0.0129 0.0716 0.6241
Onchocerca volvulus 0.0027 0.0088 0.0122
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.0716 0.7623
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0077 0.0396 0.0792
Loa Loa (eye worm) hypothetical protein 0.0035 0.0138 0.0202
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0097 0.0524 0.5463
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0041 0.0173 0.0252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Echinococcus granulosus chromobox protein 1 0.0068 0.0344 0.0681
Mycobacterium ulcerans hypothetical protein 0.0023 0.0066 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0716 0.7654
Treponema pallidum acyl carrier protein 0.0066 0.033 1
Echinococcus granulosus geminin 0.0518 0.3117 0.6225
Schistosoma mansoni intermediate filament proteins 0.0027 0.0088 0.0175
Schistosoma mansoni aryl hydrocarbon receptor 0.0016 0.0021 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.002 0.0137
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0617 0.3725 0.6258
Brugia malayi Cathepsin L-like precursor 0.0023 0.0063 0.0083
Loa Loa (eye worm) hypothetical protein 0.0117 0.0645 0.0961
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.002 0.0137
Brugia malayi AMP-binding enzyme family protein 0.0617 0.3725 0.4933
Mycobacterium ulcerans dehydrogenase 0.0041 0.0173 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1124
Onchocerca volvulus 0.003 0.0108 0.0151
Trypanosoma cruzi acyl transferase-like protein, putative 0.0041 0.0177 0.1726
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.002 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0159 0.1368
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0138 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0177 0.1526
Echinococcus granulosus acyl carrier protein mitochondrial 0.0066 0.033 0.0654
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0073 0.0372 0.0588
Echinococcus granulosus cathepsin l1 0.0023 0.0063 0.012
Plasmodium vivax vivapain-3 0.0017 0.0031 0.0004
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0066 0.033 0.0516
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0177 0.1526
Echinococcus multilocularis dna polymerase kappa 0.002 0.0046 0.0043
Mycobacterium tuberculosis Hypothetical protein 0.0197 0.1136 0.1879
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1124
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0034 0.0047
Onchocerca volvulus Fatty acid synthase homolog 0.1177 0.7177 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0244 0.0361
Leishmania major cathepsin L-like protease 0.0034 0.0131 0.1001
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0122 0.2072
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0544 0.3276 0.5503
Echinococcus granulosus cysteine protease 0.0017 0.0031 0.0056
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0038 0.02
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0716 0.7654
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0122 0.1122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0038 0.0034
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0081 0.0674
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0202 0.02
Echinococcus multilocularis musashi 0.0027 0.0088 0.0085
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0038 0.005
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0066 0.033 0.0437
Mycobacterium ulcerans thioesterase TesA 0.0544 0.3276 0.5495
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1124
Echinococcus granulosus dna polymerase eta 0.002 0.0046 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0202 0.0404
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0066 0.0061
Brugia malayi hypothetical protein 0.0036 0.0143 0.0189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0716 0.7654
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0034 0.0083
Mycobacterium ulcerans oxidoreductase 0.0041 0.0173 0.0242
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0164 0.0933 0.186
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0097 0.0823
Onchocerca volvulus 0.0034 0.0131 0.0183
Toxoplasma gondii quinone oxidoreductase, putative 0.0041 0.0173 0.0334
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0041 0.0173 0.026
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0066 0.0079
Onchocerca volvulus 0.0034 0.0131 0.0183
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0034 0.0159
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0131 0.1001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0081 0.0118
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0205 0.1187 0.1967
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0694 0.4197 0.7059
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0164 0.0933 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0121 0.0242
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0034 0.0159
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0077 0.0396 0.3467
Schistosoma mansoni smad1 5 8 and 0.0017 0.0025 0.0051
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0164 0.0933 0.1529
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.003 0.0225
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0372 0.0578
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0371 0.2211 0.3698
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0131 0.2281
Echinococcus granulosus lamin 0.0027 0.0088 0.017
Loa Loa (eye worm) hypothetical protein 0.01 0.0541 0.0804
Loa Loa (eye worm) hypothetical protein 0.01 0.0541 0.0804
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0034 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0031 0.0248
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0046 0.041
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0694 0.4197 0.7054
Plasmodium falciparum acyl carrier protein 0.0066 0.033 0.3317
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0064
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.01 0.0541 0.088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Echinococcus multilocularis geminin 0.0518 0.3117 0.3115
Schistosoma mansoni cpg binding protein 0.0058 0.028 0.056
Echinococcus granulosus AMP dependent ligase 0.0067 0.0336 0.0665
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0041 0.0173 0.0252
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0041 0.0173 0.0242
Mycobacterium ulcerans quinone oxidoreductase 0.0041 0.0173 0.0242
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.002 0.0137
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0076 0.0073
Mycobacterium tuberculosis Possible dehydrogenase 0.0041 0.0173 0.0252
Echinococcus multilocularis Smad4 0.0017 0.0025 0.0023
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0046 0.0283
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0041 0.0177 0.1556
Brugia malayi PAS domain containing protein 0.0016 0.002 0.0026
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0081 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0202 0.0404
Entamoeba histolytica hypothetical protein 0.0036 0.0143 0.2535
Schistosoma mansoni hypothetical protein 0.0036 0.0143 0.0285
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.01 0.0541 0.0873
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0036 0.0277
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0166 0.3054
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0041 0.0173 0.0242
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0121 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.041
Plasmodium vivax vivapain-2 0.0034 0.0131 0.1121
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0077 0.0396 0.3376
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0159 0.0222
Loa Loa (eye worm) cysteine protease 0.0034 0.0131 0.0193
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0306 0.061
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.1419 0.2119
Echinococcus granulosus tar DNA binding protein 0.0062 0.0306 0.0605
Brugia malayi Cathepsin L-like precursor 0.0034 0.0131 0.0174
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0306 0.0453
Schistosoma mansoni rotamase 0.0033 0.0127 0.0254
Loa Loa (eye worm) latrophilin receptor protein 2 0.0054 0.0258 0.0381
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0121 0.0209
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0716 0.7654
Loa Loa (eye worm) hypothetical protein 0.0077 0.0396 0.0589
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0073 0.0608
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0122 0.0211
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0177 0.0246
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0131 0.0129
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0138 0.0135
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0037 0.0149 0.0299
Schistosoma mansoni ran 0.0026 0.0081 0.0162
Brugia malayi chromobox protein homolog 3 0.0038 0.0159 0.0211
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0031 0.0119
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0822 0.082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1124
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0034 0.0161
Mycobacterium ulcerans acyl carrier protein 0.0066 0.033 0.0507
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0077 0.0396 0.0394
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0164 0.0933 0.1529
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.041
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0034 0.0159
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0122 0.0918
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0173 0.1495
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0041 0.0173 0.1511
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.002 0.0137
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0822 0.1642
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0034 0.0287
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0073 0.0608
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0025 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0081 0.0565
Schistosoma mansoni acyl carrier protein 0.0066 0.033 0.0659
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0121 0.1113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Loa Loa (eye worm) ctsf protein 0.0034 0.0131 0.0193
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0066 0.033 0.0516
Mycobacterium tuberculosis Conserved hypothetical protein 0.0066 0.033 0.0516
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.003 0.0115
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0016 0.002 0.0137
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0066 0.0418
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0653 0.3947 0.6637
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0041 0.0173 0.0242
Loa Loa (eye worm) hypothetical protein 0.003 0.0108 0.0158
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0046 0.0036
Echinococcus granulosus importin subunit beta 1 0.0035 0.0138 0.027
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0016 0.002 0.0137
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0694 0.4197 0.7059
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0121 0.1229
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.01 0.0541 0.0873
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0012 0.0009
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0173 0.1681
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0822 0.1089
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0041 0.0173 0.0242
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0121 0.0119
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0205 0.1187 0.1973
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0038 0.0053
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0046 0.0086
Onchocerca volvulus 0.0023 0.0066 0.0093
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0041 0.0173 0.0242
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0041 0.0173 0.179
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0076 0.0146
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0034 0.0047
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0138 0.1407
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0121 0.1009
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0034 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Entamoeba histolytica hypothetical protein 0.0028 0.0097 0.151
Loa Loa (eye worm) acetyltransferase 0.0146 0.0822 0.1225
Schistosoma mansoni hypothetical protein 0.0066 0.033 0.0659
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0076 0.0631
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0066 0.0088
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0077 0.0396 0.0787
Mycobacterium tuberculosis Conserved protein 0.0197 0.1136 0.1879
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0054 0.0258 0.0255
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0046 0.0232
Loa Loa (eye worm) hypothetical protein 0.0054 0.0258 0.0381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1124
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0032 0.0043
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0143 0.014
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0046 0.0365
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0073 0.0372 0.0588
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0066 0.0061
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.003 0.001
Schistosoma mansoni single-minded 0.0016 0.002 0.0039
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0122 0.1122
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0131 0.1223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Brugia malayi cathepsin L-like precursor 0.0023 0.0063 0.0083
Brugia malayi CXXC zinc finger family protein 0.0058 0.028 0.0371
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.041
Loa Loa (eye worm) hypothetical protein 0.0041 0.0173 0.0255
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0011 0.0015
Plasmodium vivax unspecified product 0.0017 0.0031 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0066 0.033 0.348
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0066 0.0071
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0081 0.0674
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0046 0.0365
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0088 0.0127
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0097 0.085
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0054 0.0258 0.0509
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0076 0.0099
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0041 0.0173 0.0341
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0038 0.0086
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0046 0.0091
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0469 0.2814 0.4718
Schistosoma mansoni [ACP] S-malonyltransferase 0.0041 0.0177 0.0354
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0188 0.1621
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0188 0.0368
Mycobacterium ulcerans polyketide synthase Pks9 0.0432 0.2584 0.4324
Brugia malayi MH1 domain containing protein 0.0017 0.0025 0.0034
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0046 0.0339
Brugia malayi RNA binding protein 0.0062 0.0306 0.0405
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0025 0.0023
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0188 0.037
Giardia lamblia DINP protein human, muc B family 0.002 0.0046 0.0103
Leishmania major oxidoreductase, putative 0.0041 0.0173 0.1377
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0976 0.5937 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0034 0.013
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0164 0.0933 1
Echinococcus multilocularis cysteine protease 0.0034 0.0131 0.0129
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0173 0.3228
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0073 0.0608
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0041
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0041 0.0173 0.0252
Entamoeba histolytica cysteine protease, putative 0.0034 0.0131 0.2281
Mycobacterium ulcerans thioesterase 0.0544 0.3276 0.5495
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0081 0.0427
Chlamydia trachomatis malonyl CoA-ACP transacylase 0.0041 0.0177 0.1726
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0036 0.0148 0.0217
Trichomonas vaginalis adenylate cyclase, putative 0.0016 0.002 0.0137
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0633 0.3824 0.6426
Brugia malayi Cathepsin L-like precursor 0.0034 0.0131 0.0174
Brugia malayi Latrophilin receptor protein 2 0.0054 0.0258 0.0341
Brugia malayi Calcitonin receptor-like protein seb-1 0.0171 0.098 0.1298
Mycobacterium leprae Probable oxidireductase 0.0041 0.0173 0.026
Echinococcus multilocularis cathepsin L 0.0017 0.0031 0.0028
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0088 0.0116
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0306 0.061
Trichomonas vaginalis rotamase, putative 0.0033 0.0127 0.1085
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0041 0.0173 0.3228
Loa Loa (eye worm) hypothetical protein 0.0023 0.0063 0.009
Schistosoma mansoni microtubule-associated protein tau 0.0683 0.413 0.8249
Loa Loa (eye worm) hypothetical protein 0.0027 0.0088 0.0127
Schistosoma mansoni hypothetical protein 0.0117 0.0645 0.1289
Schistosoma mansoni [ACP] S-malonyltransferase 0.0041 0.0177 0.0354
Mycobacterium ulcerans polyketide synthase 0.0653 0.3947 0.6631
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0034 0.0045
Echinococcus multilocularis snurportin 1 0.0372 0.2214 0.2211
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0063 0.0726
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0025 0.0045
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0073 0.0372 0.0578
Mycobacterium ulcerans hypothetical protein 0.0066 0.033 0.0507
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0031 0.0248
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0143 0.0285
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0038 0.0035
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0063 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1124
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0077 0.0396 0.0792
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0046 0.0036
Echinococcus multilocularis chromobox protein 1 0.0068 0.0344 0.0341
Schistosoma mansoni alcohol dehydrogenase 0.0041 0.0173 0.0346
Plasmodium vivax vivapain-1 0.0017 0.0031 0.0004
Mycobacterium ulcerans polyketide synthase MbtC 0.0164 0.0933 0.1529
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1124
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0037 0.0149 0.0198
Echinococcus multilocularis lamin 0.0027 0.0088 0.0085
Brugia malayi Importin beta-1 subunit 0.0035 0.0138 0.0183
Brugia malayi MH2 domain containing protein 0.0243 0.1419 0.188
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0127 0.1085
Brugia malayi N-terminal motif family protein 0.0185 0.1064 0.1409
Schistosoma mansoni cpg binding protein 0.0061 0.0301 0.0601
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0081 0.0079
Schistosoma mansoni smad1 5 8 and 0.0017 0.0025 0.0051
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0173 0.1495
Schistosoma mansoni importin beta-1 0.0035 0.0138 0.0276
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0095
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0131 0.2281
Brugia malayi Cathepsin L-like precursor 0.0034 0.0131 0.0174
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0041 0.0173 0.0242
Loa Loa (eye worm) hypothetical protein 0.1098 0.6689 1
Brugia malayi Cathepsin L-like precursor 0.0034 0.0131 0.0174
Echinococcus granulosus ubiquitin specific protease 41 0.0077 0.0396 0.0787
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0306 0.0453
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0031 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.041
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0306 0.061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0716 0.7654
Loa Loa (eye worm) hypothetical protein 0.0041 0.0177 0.0261
Toxoplasma gondii cathepsin CPL 0.0034 0.0131 0.0233
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0131 0.0183
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0034 0.0068
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0097 0.0823
Loa Loa (eye worm) hypothetical protein 0.0041 0.0173 0.0255
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0173 0.1681
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0066 0.033 0.0327
Mycobacterium tuberculosis Possible dehydrogenase 0.0041 0.0173 0.0252
Leishmania major cathepsin L-like protease 0.0129 0.0716 0.6241
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0164 0.0933 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0066 0.0061
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0188 0.0368
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1124
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.2214 0.3307
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0038 0.0169
Loa Loa (eye worm) hypothetical protein 0.0185 0.1064 0.1587
Mycobacterium ulcerans Type I modular polyketide synthase 0.0653 0.3947 0.6631
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.01 0.0541 0.0873
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0166 0.1499
Mycobacterium tuberculosis Probable thioesterase TesA 0.0544 0.3276 0.55
Schistosoma mansoni smad1 5 8 and 0.0017 0.0025 0.0051
Echinococcus multilocularis cpg binding protein 0.0061 0.0301 0.0298
Onchocerca volvulus 0.0034 0.0131 0.0183
Trichomonas vaginalis ran, putative 0.0026 0.0081 0.0681
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0164 0.0933 0.0931
Mycobacterium ulcerans oxidoreductase 0.0041 0.0173 0.0242
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0031 0.0119
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0164 0.0933 1
Brugia malayi MH1 domain containing protein 0.0017 0.0025 0.0034
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0046 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0204 0.1183 0.2358
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0034 0.0287
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0073 0.0608
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0173 0.023
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0025
Schistosoma mansoni DNA polymerase eta 0.002 0.0046 0.0091
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0121 0.0161
Plasmodium falciparum importin beta, putative 0.0035 0.0138 0.1192
Leishmania major GTP-binding protein, putative 0.0026 0.0081 0.0552
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0041 0.0173 0.0242
Loa Loa (eye worm) acyl carrier protein 0.03 0.1774 0.2649
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0034 0.0031
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0121 0.0119
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0097 0.0823
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0073 0.0608
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0164 0.0933 0.8188
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0077 0.0396 0.3289
Loa Loa (eye worm) hypothetical protein 0.0322 0.1905 0.2845
Toxoplasma gondii acyl carrier protein ACP 0.0066 0.033 0.0709
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0173 0.1681
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0041 0.0173 0.0171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0716 0.7654
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0073 0.0372 0.0595
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0797 0.1587
Loa Loa (eye worm) hypothetical protein 0.0023 0.0063 0.009
Giardia lamblia Methyltransferase like 2 0.0197 0.1136 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0076 0.0151
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0041 0.0173 0.0252
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0306 0.0405
Schistosoma mansoni hypothetical protein 0.0372 0.2214 0.4422
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0038 0.0023
Entamoeba histolytica hypothetical protein 0.0025 0.0076 0.1019
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0164 0.0933 0.1392
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0054 0.0258 0.0341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1124
Onchocerca volvulus 0.0077 0.0395 0.0551
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0034 0.013
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0122 0.1237
Loa Loa (eye worm) hypothetical protein 0.0038 0.0159 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Brugia malayi Heterochromatin protein 1 0.0068 0.0344 0.0455
Echinococcus multilocularis AMP dependent ligase 0.0067 0.0336 0.0333
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0131 0.0174
Trypanosoma cruzi acyl transferase-like protein 0.0041 0.0177 0.1726
Brugia malayi follicle stimulating hormone receptor 0.0229 0.1335 0.1768
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0131 0.0193
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0077 0.0396 0.8273
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0131 0.0193
Brugia malayi Smad1 0.0017 0.0025 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0716 0.7654
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0159 0.1368
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0123
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0617 0.3725 0.5567
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0034 0.013
Mycobacterium leprae Probable polyketide synthase Pks1 0.0694 0.4197 0.7059
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0046 0.006
Schistosoma mansoni methyltransferase-related 0.0197 0.1136 0.2268
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0131 0.1121
Leishmania major cathepsin L-like protease 0.0034 0.0131 0.1001
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0038 0.0071
Brugia malayi Cathepsin L-like precursor 0.0034 0.0131 0.0174
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0034 0.0132
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0088 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0031 0.0041
Echinococcus granulosus cpg binding protein 0.0061 0.0301 0.0595
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.041
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0034 0.0159
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0034 0.013
Mycobacterium ulcerans Type I modular polyketide synthase 0.0653 0.3947 0.6631
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0121 0.0237
Mycobacterium ulcerans quinone oxidoreductase 0.0041 0.0173 0.0242
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0041 0.0177 0.1629
Brugia malayi RNA, U transporter 1 0.0099 0.0533 0.0707
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0037 0.0149 0.0219
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0131 0.0183
Echinococcus granulosus Smad4 0.0017 0.0025 0.0045
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0653 0.3947 0.5228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0525 0.3161 0.5308
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0716 0.7654
Echinococcus granulosus GPCR family 2 0.0054 0.0258 0.0509
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0164 0.0933 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0525 0.3161 0.53
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0041 0.0173 0.0242
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0041 0.0177 0.0249
Schistosoma mansoni [ACP] S-malonyltransferase 0.0041 0.0177 0.0354
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0121 0.1229
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0202 0.0399
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0041 0.0173 0.0242
Leishmania major cathepsin L-like protease 0.0034 0.0131 0.1001
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.0372 0.0492
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0432 0.2584 0.4334
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0073 0.0608
Mycobacterium ulcerans polyketide synthase MbtD 0.0201 0.1161 0.1913
Leishmania major cathepsin L-like protease 0.0034 0.0131 0.1001
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0046 0.041
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0041 0.0177 0.0235
Echinococcus multilocularis cysteine protease 0.0034 0.0131 0.0129
Trypanosoma cruzi major cysteine proteinase, putative 0.0101 0.0546 0.5766
Onchocerca volvulus 0.0058 0.028 0.0391
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0073 0.0372 0.0588
Leishmania major DNA polymerase kappa, putative 0.002 0.0046 0.0232
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0013 0.001
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.0396 0.42
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0432 0.2584 0.4324
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0202 0.0404
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0127 0.0186
Trypanosoma brucei oxidoreductase, putative 0.0041 0.0173 0.179
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0046 0.0091
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0073 0.0608
Toxoplasma gondii acyl transferase domain-containing protein 0.0041 0.0177 0.0343
Mycobacterium ulcerans quinone reductase Qor 0.0041 0.0173 0.0242
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0034 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Echinococcus granulosus chromobox protein 1 0.0068 0.0344 0.0681
Trichomonas vaginalis conserved hypothetical protein 0.0197 0.1136 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0716 0.7654
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0131 0.0129
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0694 0.4197 0.7054
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0694 0.4197 0.7057
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0016 0.0021 0.0037
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0121 0.0119
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0013 0.002
Loa Loa (eye worm) fibroinase 0.0034 0.0131 0.0193
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0046 0.0283
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.041
Chlamydia trachomatis acyl carrier protein 0.0066 0.033 0.3394
Toxoplasma gondii type I fatty acid synthase, putative 0.0695 0.4203 1
Onchocerca volvulus 0.0034 0.0131 0.0183
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0164 0.0933 1
Leishmania major DNA polymerase eta, putative 0.002 0.0046 0.0232
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0066 0.0061
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0046 0.0283
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0038 0.0299
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0073 0.0608
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0716 0.7654
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0173 0.023
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0653 0.3947 0.6634
Toxoplasma gondii type I fatty acid synthase, putative 0.0465 0.2788 0.6605
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0077 0.0396 0.0525
Entamoeba histolytica hypothetical protein 0.0036 0.0143 0.2535
Echinococcus granulosus snurportin 1 0.0372 0.2214 0.4419
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0066 0.0088
Loa Loa (eye worm) hypothetical protein 0.0023 0.0063 0.009
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.0396 0.4123
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0081 0.0113
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.0622 0.1409
Echinococcus granulosus dna polymerase kappa 0.002 0.0046 0.0086
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0066 0.033 0.3394
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0036 0.0277
Mycobacterium ulcerans Type I modular polyketide synthase 0.0653 0.3947 0.6631
Schistosoma mansoni hypothetical protein 0.0054 0.0258 0.0515
Schistosoma mansoni cpg binding protein 0.0061 0.0301 0.0601
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0034 0.0063
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0138 0.1407
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0046 0.0026
Echinococcus granulosus expressed protein 0.0033 0.0127 0.0248
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0066 0.0088
Schistosoma mansoni chromobox protein 0.0068 0.0344 0.0687
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0264 0.1551 0.2581
Brugia malayi hypothetical protein 0.0052 0.0244 0.0323
Echinococcus multilocularis NADH dehydrogenase 0.0066 0.033 0.0327
Mycobacterium ulcerans polyketide synthase Pks13 0.0976 0.5937 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0031 0.0233
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0118 0.0647 0.687
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0038 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0063 0.0516
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0131 0.0129
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0066 0.033 0.0516
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0653 0.3947 0.6631
Schistosoma mansoni ran 0.0026 0.0081 0.0162
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0131 0.0257
Plasmodium vivax vivapain-2 0.0034 0.0131 0.1121
Schistosoma mansoni hypothetical protein 0.0518 0.3117 0.6227
Echinococcus multilocularis expressed protein 0.0033 0.0127 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0716 0.7654
Plasmodium vivax hypothetical protein, conserved 0.0097 0.0524 0.5463
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0038 0.0013
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0066 0.033 0.0489
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0131 0.1121
Echinococcus granulosus lamin dm0 0.0027 0.0088 0.017
Brugia malayi Alcohol dehydrogenase class III 0.0041 0.0173 0.023
Echinococcus granulosus dnaJ subfamily B 0.0825 0.5006 1
Echinococcus granulosus smad 0.0017 0.0025 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.002 0.0137
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0131 0.0183
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1124
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0034 0.0287
Trypanosoma brucei oxidoreductase, putative 0.0041 0.0173 0.179
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0653 0.3947 0.6637
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0201 0.1161 0.1921
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0013 0.0025
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0143 0.028
Echinococcus granulosus intermediate filament protein 0.0027 0.0088 0.017
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.002 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Leishmania major importin beta-1 subunit, putative 0.0028 0.0097 0.0696
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0031 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.041
Leishmania major zinc binding dehydrogenase-like protein 0.0041 0.0173 0.1377
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0095
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0202 0.0268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0164 0.0933 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.0716 0.7623
Leishmania major zinc-binding dehydrogenase-like protein 0.0041 0.0173 0.1377
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1124
Leishmania major hypothetical protein, conserved 0.0197 0.1136 1
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0166 0.1193
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0046 0.0043
Echinococcus multilocularis aryl hydrocarbon receptor 0.0052 0.0246 0.0243
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0073 0.0372 0.0588
Brugia malayi latrophilin 2 splice variant baaae 0.0117 0.0645 0.0855
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0012 0.0024
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0173 0.1681
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0171 0.098 0.1461
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0038 0.0164
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0131 0.0129
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0031 0.0056
Entamoeba histolytica hypothetical protein 0.0036 0.0143 0.2535
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0066 0.0418
Trypanosoma brucei acyl transferase-like protein 0.0041 0.0177 0.1833
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0041 0.0173 0.026
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0041 0.0173 0.0255
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0081 0.0565
Loa Loa (eye worm) Smad1 0.0017 0.0025 0.0034
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0336 0.0534
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0131 0.1124
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0031 0.0119
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0076 0.0612
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0306 0.061
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0034 0.0083
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0188 0.1743
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.068 0.1359
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0073 0.0372 0.0578
Echinococcus multilocularis dna polymerase eta 0.002 0.0046 0.0043
Schistosoma mansoni Smad4 0.0017 0.0025 0.0051
Schistosoma mansoni lamin 0.0027 0.0088 0.0175
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.1419 0.2119
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0016 0.0021 0.0019
Schistosoma mansoni hypothetical protein 0.0054 0.0258 0.0515
Brugia malayi intermediate filament protein 0.0027 0.0088 0.0116
Loa Loa (eye worm) acyl carrier protein 0.0066 0.033 0.0489
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0073 0.0372 0.0578
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0344 0.3
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.041
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0121 0.0164
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0038 0.02
Leishmania major cathepsin L-like protease 0.0034 0.0131 0.1001
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0066 0.0061
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0066 0.081
Loa Loa (eye worm) hypothetical protein 0.0036 0.0148 0.0217
Trypanosoma brucei unspecified product 0.002 0.0046 0.041
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0173 0.1681
Onchocerca volvulus Putative alcohol dehydrogenase 0.0041 0.0173 0.0242
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.041
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0121 0.1009
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0225 0.1307 0.2169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0265
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.1238 0.755 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1124
Schistosoma mansoni hypothetical protein 0.0054 0.0258 0.0515
Brugia malayi TAR-binding protein 0.0062 0.0306 0.0405
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0034 0.0063
Onchocerca volvulus 0.0023 0.0063 0.0087
Plasmodium vivax acyl carrier protein, putative 0.0066 0.033 0.3317
Schistosoma mansoni hypothetical protein 0.0054 0.0258 0.0515
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0173 0.1681
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0202 0.0298
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0121 0.0119
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.0716 0.7623
Mycobacterium leprae conserved hypothetical protein 0.0066 0.033 0.0524
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0046 0.0026
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.0396 0.4123
Onchocerca volvulus 0.0052 0.0244 0.034
Brugia malayi isocitrate dehydrogenase 0.0032 0.0121 0.0161
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0131 0.0263
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0976 0.5937 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0121 0.0911
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0344 0.051
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0041 0.0173 0.0252
Brugia malayi Cathepsin L-like precursor 0.0034 0.0131 0.0174
Entamoeba histolytica acyl-CoA synthetase, putative 0.0067 0.0336 0.6898
Loa Loa (eye worm) hypothetical protein 0.0036 0.0148 0.0217
Schistosoma mansoni hypothetical protein 0.0825 0.5006 1
Brugia malayi CHD4 protein 0.0014 0.0013 0.0017
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0041 0.0173 0.0252
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0653 0.3947 0.6634
Onchocerca volvulus 0.0041 0.0173 0.0242
Echinococcus multilocularis GPCR, family 2 0.0054 0.0258 0.0255
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0038 0.0299
Brugia malayi hypothetical protein 0.0037 0.0149 0.0198
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0037 0.0149 0.0198
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0077 0.0396 0.0394
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0202 0.0399
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0121 0.0209
Mycobacterium tuberculosis Probable oxidoreductase 0.0041 0.0173 0.0252
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0131 0.1121
Echinococcus multilocularis dnaJ subfamily B 0.0825 0.5006 0.5005
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0041 0.0173 0.0252
Loa Loa (eye worm) fatty acid synthase 0.0644 0.3894 0.5819
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.009 0.076
Schistosoma mansoni hypothetical protein 0.0518 0.3117 0.6227
Loa Loa (eye worm) hypothetical protein 0.0034 0.0131 0.0193
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0164 0.0933 0.1236
Schistosoma mansoni ap endonuclease 0.0019 0.0038 0.0076
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0076 0.0735
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1124
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0306 0.061
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0131 0.0263
Loa Loa (eye worm) hypothetical protein 0.0041 0.0173 0.0255
Plasmodium falciparum cysteine proteinase falcipain 1 0.0017 0.0031 0.0004
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0694 0.4197 0.7057
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0066 0.081
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0041
Schistosoma mansoni ap endonuclease 0.0019 0.0038 0.0076
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0031 0.0061

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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