Detailed information for compound 1518401

Basic information

Technical information
  • TDR Targets ID: 1518401
  • Name: 2-[3-(3,4-dimethylphenyl)-2',4-dioxospiro[1,3 -thiazolidine-2,3'-indole]-1'-yl]-N-(2-phenyl ethyl)acetamide
  • MW: 485.597 | Formula: C28H27N3O3S
  • H donors: 1 H acceptors: 3 LogP: 4.55 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN1c2ccccc2C2(C1=O)SCC(=O)N2c1ccc(c(c1)C)C)NCCc1ccccc1
  • InChi: 1S/C28H27N3O3S/c1-19-12-13-22(16-20(19)2)31-26(33)18-35-28(31)23-10-6-7-11-24(23)30(27(28)34)17-25(32)29-15-14-21-8-4-3-5-9-21/h3-13,16H,14-15,17-18H2,1-2H3,(H,29,32)
  • InChiKey: WACFMSKDQVNAPO-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-[3'-(3,4-dimethylphenyl)-2,4'-dioxo-spiro[indoline-3,2'-thiazolidine]-1-yl]-N-(2-phenylethyl)acetamide
  • 2-[3'-(3,4-dimethylphenyl)-2,4'-dioxo-1-spiro[indoline-3,2'-thiazolidine]yl]-N-(2-phenylethyl)acetamide
  • 2-[3'-(3,4-dimethylphenyl)-2,4'-diketo-spiro[indoline-3,2'-thiazolidine]-1-yl]-N-(2-phenylethyl)acetamide
  • 2-[3-(3,4-dimethylphenyl)-2',4-dioxo-spiro[1,3-thiazolidine-2,3'-indole]-1'-yl]-N-(2-phenylethyl)ethanamide
  • E897-0428
  • NCGC00126339-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Onchocerca volvulus 0.0018 0.0015 0.0022
Trypanosoma brucei beta tubulin 0.0747 0.3015 0.5558
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.0547 0.1007
Schistosoma mansoni DNA helicase recq1 0.0029 0.0061 0.0109
Echinococcus multilocularis Niemann Pick C1 protein 0.0297 0.1162 0.1158
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0097 0.017
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.0937 0.1721
Plasmodium falciparum thioredoxin reductase 0.0048 0.014 0.024
Brugia malayi Tubulin beta chain 0.0405 0.1607 0.2962
Echinococcus granulosus Tubulin alpha 1 chain 0.0996 0.4039 0.7448
Echinococcus multilocularis tubulin alpha chain 0.0996 0.4039 0.4036
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0182 0.0333
Entamoeba histolytica hypothetical protein 0.0073 0.0243 0.0448
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0101 0.0356 0.0352
Echinococcus granulosus Tubulin alpha 1 chain 0.0996 0.4039 0.7448
Echinococcus granulosus Smad4 0.0025 0.0042 0.0069
Onchocerca volvulus 0.0028 0.0054 0.027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0091 0.0161
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.0395 0.1396
Loa Loa (eye worm) patched family protein 0.0018 0.0015 0.0024
Mycobacterium tuberculosis Conserved protein 0.0108 0.0384 0.1354
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.001 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0054 0.0092
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0015 0.044
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0049 0.0143 0.0139
Loa Loa (eye worm) hypothetical protein 0.0039 0.0101 0.0184
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0048 0.0137 0.0132
Onchocerca volvulus 0.0057 0.0176 0.103
Brugia malayi Patched related family protein 12 0.0018 0.0015 0.0024
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0025 0.0044 0.0063
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0219 0.0396
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0101 0.0356 0.0653
Onchocerca volvulus 0.0101 0.0356 0.2158
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.013 0.024
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0025 0.0044 0.0073
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.0384 0.1354
Brugia malayi Patched family protein 0.0018 0.0015 0.0024
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0263 0.1021 0.1882
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0041 0.0067
Entamoeba histolytica recQ family DNA helicase 0.0015 0.0002 0.0004
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0025 0.0044 0.0077
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.0018
Echinococcus multilocularis tyrosine protein kinase Srms 0.0042 0.0115 0.0111
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0197 0.036
Echinococcus granulosus tubulin subunit beta 0.1332 0.5422 1
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0039 0.0101 0.0182
Onchocerca volvulus 0.0405 0.1607 1
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0015 0.001
Leishmania major cathepsin L-like protease 0.0065 0.021 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0342 0.1349 0.2482
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0127 0.0465 0.0855
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0053 0.0089
Trypanosoma cruzi tubulin gamma chain 0.0801 0.3238 0.5971
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0107 0.0379 0.0375
Brugia malayi Patched family protein 0.0018 0.0015 0.0024
Echinococcus multilocularis bloom syndrome protein 0.0042 0.0114 0.011
Loa Loa (eye worm) hypothetical protein 0.0053 0.016 0.0292
Echinococcus granulosus eukaryotic initiation factor 4A 0.0025 0.0044 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0101 0.0356 0.0653
Onchocerca volvulus 0.0018 0.0015 0.0022
Echinococcus granulosus expressed conserved protein 0.0279 0.1088 0.2001
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.0384 0.0379
Brugia malayi nuclear receptor RXR 0.0048 0.0137 0.0249
Leishmania major alpha tubulin 0.0996 0.4039 0.7448
Onchocerca volvulus 0.0051 0.0149 0.0863
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.0384 0.1354
Loa Loa (eye worm) glutathione reductase 0.0048 0.014 0.0255
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0042 0.0069
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0102 0.0097
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0039 0.0101 0.0184
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0048 0.0137 0.0951
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0054 0.0097
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0384 0.0703
Brugia malayi Tyrosine-protein kinase abl-1 0.013 0.0477 0.0877
Trypanosoma brucei zeta tubulin 0.0902 0.3651 0.6731
Leishmania major beta tubulin 0.1332 0.5422 1
Trypanosoma brucei alpha tubulin 0.0996 0.4039 0.7448
Brugia malayi Thioredoxin reductase 0.0048 0.014 0.0255
Leishmania major beta tubulin 0.1332 0.5422 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0049 0.0143 0.0256
Echinococcus multilocularis follistatin 0.0039 0.0101 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0043 0.0071
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.0384 0.0704
Echinococcus granulosus integrin beta 2 0.0237 0.0918 0.1686
Leishmania major eukaryotic initiation factor 4a, putative 0.0025 0.0044 0.0073
Trichomonas vaginalis esterase, putative 0.0108 0.0384 0.07
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0049 0.0143 0.0256
Schistosoma mansoni tyrosine kinase 0.0019 0.002 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.013 0.0232
Trypanosoma brucei beta tubulin 0.1332 0.5422 1
Brugia malayi protein-tyrosine kinase 0.0042 0.0115 0.021
Plasmodium vivax tubulin gamma chain, putative 0.0801 0.3238 0.5972
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0132 0.0241
Echinococcus multilocularis Tubulin beta 2C chain 0.1332 0.5422 0.542
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Leishmania major gamma-tubulin 0.0801 0.3238 0.5969
Schistosoma mansoni Smad4 0.0025 0.0042 0.0073
Plasmodium falciparum tubulin beta chain 0.1332 0.5422 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0137 0.0249
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0061 0.0109
Leishmania major alpha tubulin 0.0996 0.4039 0.7448
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0025 0.0042 0.0069
Plasmodium vivax vivapain-2 0.0017 0.0011 0.0021
Loa Loa (eye worm) DR-78 0.0048 0.0137 0.0249
Echinococcus granulosus cathepsin l1 0.0017 0.0011 0.0013
Echinococcus granulosus cpg binding protein 0.0031 0.0069 0.0119
Leishmania major hypothetical protein, conserved 0.0126 0.0457 0.0836
Onchocerca volvulus Putative organic anion transporter 0.0057 0.0176 0.103
Schistosoma mansoni integrin alpha 0.0156 0.0585 0.1075
Loa Loa (eye worm) acetyltransferase 0.0147 0.0547 0.1007
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0019 0.002 0.003
Onchocerca volvulus 0.0018 0.0015 0.0022
Brugia malayi nuclear receptor NHR-67 0.0048 0.0137 0.0249
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0041 0.0112
Trypanosoma cruzi zeta tubulin, putative 0.0902 0.3651 0.6732
Leishmania major beta tubulin 0.1332 0.5422 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0011 0.0006
Entamoeba histolytica cysteine protease, putative 0.0017 0.0011 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0082 0.0143
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0042 0.0073
Schistosoma mansoni alpha tubulin 0.0996 0.4039 0.7449
Loa Loa (eye worm) hypothetical protein 0.017 0.0639 0.1175
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0541 0.2167 0.2163
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.1021 0.1878
Toxoplasma gondii patched family protein 0.0018 0.0015 0.0023
Echinococcus granulosus epidermal growth factor receptor 0.0168 0.0632 0.1158
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0029 0.0061 0.0095
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0097 0.017
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.0018
Loa Loa (eye worm) patched family protein 0.0018 0.0015 0.0024
Echinococcus granulosus integrin alpha 3 0.012 0.0434 0.0794
Schistosoma mansoni tubulin subunit beta 0.1332 0.5422 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0176 0.0321
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0384 0.07
Toxoplasma gondii patched family protein 0.0018 0.0015 0.0023
Schistosoma mansoni tyrosine kinase 0.0101 0.0358 0.0657
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.021 0.0379
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Loa Loa (eye worm) hypothetical protein 0.0242 0.0937 0.1725
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0041 0.023
Giardia lamblia Gamma tubulin 0.0801 0.3238 0.5965
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0677 0.2726 0.5025
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0097 0.0092
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0041 0.023
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0405 0.1607 0.2958
Onchocerca volvulus Protein ultraspiracle homolog 0.0101 0.0356 0.2158
Leishmania major beta tubulin 0.1332 0.5422 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0079 0.0265 0.0484
Echinococcus granulosus roundabout 2 0.0031 0.0066 0.0115
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0182 0.0178
Echinococcus multilocularis protein dispatched 1 0.0145 0.0539 0.0535
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0097 0.0174
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0591 0.2373 0.4372
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0097 0.017
Echinococcus granulosus tyrosine protein kinase Fyn 0.0049 0.0143 0.0256
Echinococcus multilocularis neuropeptide s receptor 0.0482 0.1925 0.1921
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.065 0.1192
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0384 0.07
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0048 0.0137 0.0132
Loa Loa (eye worm) nuclear receptor NHR-67 0.0048 0.0137 0.0249
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0101 0.0356 0.0653
Brugia malayi hypothetical protein 0.0053 0.016 0.0292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0053 0.0089
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0097 0.0174
Plasmodium falciparum eukaryotic initiation factor 4A 0.0025 0.0044 0.0063
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0011 0.0021
Schistosoma mansoni alpha tubulin 0.0996 0.4039 0.7449
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0119 0.0212
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0021 0.0029 0.0049
Echinococcus granulosus Solute carrier organic anion transporter family 0.0057 0.0176 0.0316
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0025 0.0044 0.0077
Echinococcus multilocularis lamin 0.0028 0.0054 0.005
Brugia malayi alpha-tubulin 0.0996 0.4039 0.7449
Loa Loa (eye worm) agrin synaptic family protein 0.0039 0.0101 0.0184
Trypanosoma cruzi PAB1-binding protein , putative 0.0126 0.0457 0.084
Trichomonas vaginalis tubulin epsilon chain, putative 0.1332 0.5422 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0101 0.0356 0.0352
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.021 0.0382
Loa Loa (eye worm) hypothetical protein 0.0048 0.0137 0.0249
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Loa Loa (eye worm) hypothetical protein 0.0297 0.1162 0.2141
Echinococcus multilocularis cpg binding protein 0.0031 0.0069 0.0064
Echinococcus multilocularis L aminoadipate semialdehyde 0.017 0.0639 0.0635
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.014 0.025
Trichomonas vaginalis tubulin alpha chain, putative 0.1332 0.5422 1
Mycobacterium leprae cell division protein FtsZ 0.0342 0.1349 1
Trypanosoma brucei trypanothione reductase 0.0048 0.014 0.025
Trichomonas vaginalis tubulin beta chain, putative 0.0405 0.1607 0.2958
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0101 0.0356 0.0653
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0097 0.017
Entamoeba histolytica hypothetical protein 0.0073 0.0243 0.0448
Schistosoma mansoni hypothetical protein 0.0844 0.3413 0.6293
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0008
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0996 0.4039 0.7448
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0057 0.0176 0.0171
Schistosoma mansoni nuclear receptor 0.0048 0.0137 0.0248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0091 0.0161
Onchocerca volvulus 0.0049 0.0144 0.0831
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0687 0.2769 1
Brugia malayi Tubulin alpha-2 chain 0.0996 0.4039 0.7449
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0049 0.0143 0.0139
Schistosoma mansoni tubulin subunit beta 0.1332 0.5422 1
Plasmodium vivax tubulin beta chain, putative 0.1332 0.5422 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0082 0.0143
Leishmania major alpha tubulin 0.0996 0.4039 0.7448
Echinococcus granulosus lamin 0.0028 0.0054 0.0092
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0013
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0041 0.0072
Schistosoma mansoni hypothetical protein 0.0035 0.0083 0.015
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.0446 0.158
Onchocerca volvulus 0.0029 0.0062 0.0316
Brugia malayi nuclear receptor RXR 0.0053 0.016 0.0292
Leishmania major beta tubulin 0.1332 0.5422 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0054 0.0092
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0148 0.0552 0.0548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0013
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.0018
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.001 0.001
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0097 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.013 0.0232
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0049 0.0143 0.0139
Loa Loa (eye worm) hypothetical protein 0.0108 0.0384 0.0704
Trypanosoma brucei beta tubulin 0.1332 0.5422 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0101 0.0356 0.0653
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0057 0.0176 0.0171
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0039 0.0101 0.0184
Echinococcus multilocularis tubulin epsilon chain 0.0801 0.3235 0.3232
Brugia malayi hypothetical protein 0.0018 0.0015 0.0024
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0301 0.1181 0.2175
Brugia malayi Patched family protein 0.0018 0.0015 0.0024
Plasmodium falciparum ataxin-2 like protein, putative 0.0126 0.0457 0.0827
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0082 0.0143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.021 0.0379
Echinococcus multilocularis Tubulin alpha 1 chain 0.0996 0.4039 0.4036
Leishmania major cathepsin L-like protease 0.0017 0.0011 0.0013
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Echinococcus multilocularis 0.0094 0.033 0.0325
Brugia malayi Patched family protein 0.0018 0.0015 0.0024
Echinococcus granulosus tubulin alpha 3 chain 0.0996 0.4039 0.7448
Plasmodium vivax ataxin-2 like protein, putative 0.0126 0.0457 0.0843
Loa Loa (eye worm) hypothetical protein 0.0156 0.0583 0.1072
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0123 0.0446 0.082
Plasmodium vivax RNA helicase-1, putative 0.0025 0.0044 0.0081
Toxoplasma gondii alpha-tubulin I, putative 0.0996 0.4039 0.7449
Mycobacterium tuberculosis Conserved protein 0.0108 0.0384 0.1354
Brugia malayi Immunoglobulin I-set domain containing protein 0.011 0.0392 0.0719
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0021 0.0029 0.0049
Loa Loa (eye worm) TK protein kinase 0.011 0.0392 0.0719
Onchocerca volvulus 0.0018 0.0015 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0384 0.07
Echinococcus granulosus dnaJ subfamily B 0.0419 0.1663 0.3062
Echinococcus granulosus nuclear receptor nhr 48 0.0048 0.0137 0.0244
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0019 0.002 0.0016
Echinococcus granulosus Protein patched homolog 1 0.0127 0.0465 0.085
Brugia malayi Patched family protein 0.0018 0.0015 0.0024
Echinococcus multilocularis thyroid hormone receptor alpha 0.023 0.0886 0.0882
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.001 0.001
Schistosoma mansoni thyroid hormone receptor 0.023 0.0886 0.163
Giardia lamblia Delta tubulin 0.0342 0.1349 0.2474
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0101 0.0356 0.0653
Schistosoma mansoni smad1 5 8 and 0.0025 0.0042 0.0073
Loa Loa (eye worm) hypothetical protein 0.0039 0.0101 0.0184
Brugia malayi isocitrate dehydrogenase 0.0079 0.0265 0.0485
Trypanosoma brucei alpha tubulin 0.0996 0.4039 0.7448
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0048 0.0137 0.0249
Schistosoma mansoni tyrosine kinase 0.0162 0.0609 0.1119
Toxoplasma gondii isocitrate dehydrogenase 0.0079 0.0265 0.0484
Echinococcus granulosus alpha tubulin 0.0996 0.4039 0.7448
Schistosoma mansoni patched 1 0.0127 0.0465 0.0854
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Echinococcus multilocularis Tubulin beta 2C chain 0.1332 0.5422 0.542
Loa Loa (eye worm) hypothetical protein 0.0108 0.0384 0.0704
Echinococcus multilocularis tubulin alpha 3 chain 0.0996 0.4039 0.4036
Entamoeba histolytica hypothetical protein 0.0073 0.0243 0.0448
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0342 0.1349 0.2482
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.013 0.0237
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0049 0.0143 0.0256
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0013
Schistosoma mansoni tyrosine kinase 0.0168 0.0632 0.1161
Schistosoma mansoni nuclear receptor 0.0048 0.0137 0.0248
Echinococcus multilocularis tubulin beta 1 chain 0.1332 0.5422 0.542
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0143 0.0139
Mycobacterium ulcerans hypothetical protein 0.0108 0.0384 0.279
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0029 0.0061 0.0057
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0048 0.0137 0.0235
Leishmania major beta tubulin 0.1332 0.5422 1
Brugia malayi Kelch motif family protein 0.0049 0.0141 0.0257
Loa Loa (eye worm) hypothetical protein 0.0048 0.0137 0.0249
Leishmania major phosphopantetheinyl transferase-like protein 0.0048 0.0137 0.0245
Brugia malayi Tubulin gamma chain 0.0801 0.3238 0.5971
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0091 0.0161
Plasmodium falciparum tubulin gamma chain 0.0801 0.3238 0.5965
Echinococcus granulosus tubulin alpha chain 0.0996 0.4039 0.7448
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0243 0.0444
Schistosoma mansoni hypothetical protein 0.0123 0.0446 0.0819
Echinococcus multilocularis Tubulin beta 2C chain 0.1332 0.5422 0.542
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0079 0.0265 0.026
Loa Loa (eye worm) alpha-tubulin 0.0996 0.4039 0.7449
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0101 0.0356 0.0652
Onchocerca volvulus 0.0048 0.0137 0.0785
Toxoplasma gondii LsmAD domain-containing protein 0.0126 0.0457 0.084
Schistosoma mansoni DNA helicase recq5 0.0029 0.0061 0.0109
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0101 0.0356 0.0653
Loa Loa (eye worm) hypothetical protein 0.0167 0.0628 0.1156
Brugia malayi beta-tubulin, identical 0.1332 0.5422 1
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0342 0.1349 1
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.0384 0.07
Echinococcus granulosus tyrosine protein kinase Blk 0.0042 0.0115 0.0205
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0079 0.0265 0.026
Brugia malayi hypothetical protein 0.0049 0.0141 0.0257
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.014 0.0255
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.017 0.0639 0.1175
Schistosoma mansoni tubulin subunit beta 0.0342 0.1349 0.2485
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0149 0.0271
Brugia malayi Patched family protein 0.0018 0.0015 0.0024
Loa Loa (eye worm) hypothetical protein 0.0086 0.0296 0.0543
Echinococcus granulosus Nuclear hormone receptor HR96 0.0048 0.0137 0.0244
Loa Loa (eye worm) tubulin beta-4 chain 0.1332 0.5422 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.001 0.001
Schistosoma mansoni tyrosine kinase 0.0019 0.002 0.0033
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0057 0.0176 0.0316
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0011 0.0017
Brugia malayi prostaglandin transporter 0.0057 0.0176 0.0321
Brugia malayi Nuclear hormone receptor-like 1 0.0053 0.016 0.0292
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.0384 0.07
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.013 0.0126
Brugia malayi hypothetical protein 0.0229 0.0882 0.1623
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.0446 0.158
Leishmania major epsilon tubulin, putative 0.0801 0.3235 0.5963
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0101 0.0356 0.0653
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0025 0.0044 0.0073
Trypanosoma brucei alpha tubulin, putative 0.0405 0.1607 0.2958
Entamoeba histolytica tubulin alpha-1 chain 0.0996 0.4039 0.745
Echinococcus granulosus tubulin alpha 3 chain 0.0996 0.4039 0.7448
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0041 0.023
Echinococcus granulosus neuroglian 0.0024 0.0042 0.0069
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0186 0.0339
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0053 0.016 0.0291
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0079 0.0265 0.0484
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0011 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0011 0.0013
Echinococcus granulosus FTZ F1 alpha 0.0101 0.0356 0.0649
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0101 0.0356 0.0653
Toxoplasma gondii ABC1 family protein 0.0108 0.0384 0.0703
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0011 0.0006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.005
Brugia malayi Furin-like cysteine rich region family protein 0.0309 0.1213 0.2234
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.001 0.0015
Leishmania major cathepsin L-like protease 0.0017 0.0011 0.0013
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0054 0.0097
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0011 0.0013
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0102 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0097 0.017
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.014 0.0472
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.0384 0.279
Echinococcus granulosus tyrosine kinase 0.0042 0.0115 0.0205
Echinococcus multilocularis tubulin alpha chain 0.0996 0.4039 0.4036
Loa Loa (eye worm) hypothetical protein 0.0996 0.4039 0.7449
Echinococcus granulosus agrin 0.0039 0.0101 0.0179
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0029 0.0061 0.0057
Loa Loa (eye worm) hypothetical protein 0.0053 0.016 0.0292
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.014 0.0254
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0101 0.0356 0.0352
Loa Loa (eye worm) tubulin beta-2A chain 0.1332 0.5422 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0126 0.0457 0.0827
Echinococcus multilocularis insulin receptor 0.0101 0.0358 0.0354
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0042 0.0074
Leishmania major cathepsin L-like protease 0.0017 0.0011 0.0013
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1332 0.5422 0.542
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.013 0.0232
Echinococcus multilocularis geminin 0.0844 0.3413 0.341
Trypanosoma cruzi tubulin delta chain 0.0677 0.2726 0.5025
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.013 0.0232
Schistosoma mansoni tubulin subunit beta 0.1332 0.5422 1
Leishmania major beta tubulin 0.1332 0.5422 1
Loa Loa (eye worm) tubulin gamma chain 0.0801 0.3238 0.5971
Echinococcus granulosus beta tubulin 0.1332 0.5422 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0101 0.0356 0.0649
Onchocerca volvulus Bile acid receptor homolog 0.0101 0.0356 0.2158
Echinococcus granulosus Niemann Pick C1 protein 0.0297 0.1162 0.2137
Loa Loa (eye worm) hypothetical protein 0.0048 0.0137 0.0249
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0149 0.0273
Plasmodium vivax vivapain-2 0.0017 0.0011 0.0021
Trichomonas vaginalis tubulin, putative 0.0405 0.1607 0.2958
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0175
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0263 0.1021 0.1882
Toxoplasma gondii cathepsin CPL 0.0017 0.0011 0.0017
Schistosoma mansoni integrin alpha-ps 0.007 0.023 0.0419
Echinococcus granulosus ecdysone induced protein 78C 0.0101 0.0356 0.0649
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0053 0.016 0.0291
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.0395 0.1396
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0219 0.0396
Schistosoma mansoni lamin 0.0028 0.0054 0.0096
Trichomonas vaginalis tubulin gamma chain, putative 0.0801 0.3238 0.5969
Loa Loa (eye worm) hypothetical protein 0.0057 0.0176 0.0321
Onchocerca volvulus 0.0057 0.0176 0.103
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0101 0.0356 0.0649
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.0395 0.1396
Leishmania major cathepsin L-like protease 0.0017 0.0011 0.0013
Trypanosoma cruzi epsilon tubulin, putative 0.0801 0.3235 0.5965
Brugia malayi hypothetical protein 0.0057 0.0176 0.0321
Loa Loa (eye worm) TK/EGFR protein kinase 0.0309 0.1213 0.2234
Entamoeba histolytica tubulin alpha chain, putative 0.0996 0.4039 0.745
Brugia malayi nuclear hormone receptor family member odr-7 0.0048 0.0137 0.0249
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.0384 0.1354
Echinococcus multilocularis integrin alpha 3 0.012 0.0434 0.043
Loa Loa (eye worm) hypothetical protein 0.0057 0.0176 0.0321
Echinococcus multilocularis tubulin subunit TubB 0.0996 0.4039 0.4036
Trypanosoma cruzi epsilon tubulin, putative 0.0801 0.3235 0.5965
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0015 0.0042
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.0384 0.1354
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.0018
Brugia malayi Smad1 0.0025 0.0042 0.0074
Mycobacterium ulcerans hypothetical protein 0.0024 0.0041 0.023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0132 0.0128
Brugia malayi Nuclear hormone receptor-like 1 0.0053 0.016 0.0292
Echinococcus multilocularis Tubulin alpha 1 chain 0.0996 0.4039 0.4036
Loa Loa (eye worm) patched family protein 0.0018 0.0015 0.0024
Leishmania major beta tubulin 0.1332 0.5422 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0101 0.0356 0.0653
Brugia malayi MH2 domain containing protein 0.036 0.1422 0.262
Schistosoma mansoni blooms syndrome DNA helicase 0.0027 0.0053 0.0093
Echinococcus granulosus tubulin alpha 1C chain 0.0996 0.4039 0.7448
Leishmania major delta tubulin, putative 0.0677 0.2726 0.5024
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0688 0.1262
Mycobacterium tuberculosis Cell division protein FtsZ 0.0342 0.1349 0.4854
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0013
Brugia malayi protein C24B5.3 0.0018 0.0015 0.0024
Echinococcus granulosus tubulin beta 4A class IVa 0.1332 0.5422 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.0103 0.0173
Leishmania major beta tubulin 0.1332 0.5422 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0101 0.0356 0.0653
Echinococcus multilocularis integrin beta 2 0.0237 0.0918 0.0914
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0039 0.0101 0.0184
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.001 0.0014
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0079 0.0265 0.0471
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0053 0.016 0.0292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0091 0.0161
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0037 0.0092 0.0088
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.0014
Entamoeba histolytica hypothetical protein 0.0048 0.0137 0.0253
Plasmodium vivax tubulin alpha chain, putative 0.0996 0.4039 0.745
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.0547 0.1006
Loa Loa (eye worm) tubulin alpha-3 chain 0.0591 0.2373 0.4375
Echinococcus granulosus Tubulin beta 2C chain 0.1332 0.5422 1
Treponema pallidum ATP-dependent RNA helicase 0.0025 0.0044 0.0308
Loa Loa (eye worm) SRC-1 0.0049 0.0143 0.0261
Schistosoma mansoni hypothetical protein 0.0844 0.3413 0.6293
Echinococcus granulosus smad 0.0025 0.0042 0.0069
Loa Loa (eye worm) tubulin alpha 2 0.0654 0.2631 0.4851
Trichomonas vaginalis tubulin gamma chain, putative 0.0801 0.3235 0.5963
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0029 0.0061 0.0105
Loa Loa (eye worm) hypothetical protein 0.0057 0.0176 0.0321
Echinococcus granulosus tubulin subunit TubB 0.0996 0.4039 0.7448
Trichomonas vaginalis tubulin alpha chain, putative 0.0405 0.1607 0.2958
Loa Loa (eye worm) hypothetical protein 0.0057 0.0176 0.0321
Loa Loa (eye worm) hypothetical protein 0.0027 0.0052 0.0093
Brugia malayi Immunoglobulin I-set domain containing protein 0.0024 0.0041 0.0073
Brugia malayi Patched related family protein 10 0.0018 0.0015 0.0024
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0107 0.0379 0.0375
Loa Loa (eye worm) hypothetical protein 0.0101 0.0356 0.0653
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.053 0.0971
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.001 0.0014
Brugia malayi hypoxia-induced factor 1 0.0154 0.0575 0.1057
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0025 0.0044 0.0073
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0011 0.0013
Plasmodium vivax tubulin alpha chain, putative 0.0996 0.4039 0.745
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0042 0.0037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0132 0.024
Onchocerca volvulus 0.0048 0.0137 0.0785
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0097 0.0178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0043 0.0071
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0048 0.0137 0.0248
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0079 0.0265 0.048
Echinococcus multilocularis Smad4 0.0025 0.0042 0.0037
Plasmodium falciparum lipid/sterol:H+ symporter 0.0018 0.0015 0.0009
Loa Loa (eye worm) hypothetical protein 0.0654 0.2631 0.4851
Echinococcus multilocularis Immunoglobulin 0.0021 0.0029 0.0025
Echinococcus granulosus epidermal growth factor receptor 0.0309 0.1213 0.2231
Brugia malayi sodium-independent organic anion transporter family protein 0.0057 0.0176 0.0321
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0011 0.0017
Trichomonas vaginalis tubulin epsilon chain, putative 0.0342 0.1349 0.2482
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0384 0.0703
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0143 0.0139
Loa Loa (eye worm) beta-lactamase 0.0108 0.0384 0.0704
Trypanosoma brucei beta tubulin 0.1332 0.5422 1
Trypanosoma cruzi tubulin delta chain 0.0677 0.2726 0.5025
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0041 0.0067
Loa Loa (eye worm) hypothetical protein 0.0057 0.0176 0.0321
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0118 0.0428 0.0786
Brugia malayi hypothetical protein 0.0018 0.0015 0.0024
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0072
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.0014
Schistosoma mansoni vesicular amine transporter 0.0021 0.0029 0.0049
Echinococcus granulosus tyrosine protein kinase HCK 0.0035 0.0087 0.0152
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.001 0.0018
Giardia lamblia Alpha-tubulin 0.0996 0.4039 0.7445
Echinococcus multilocularis isocitrate dehydrogenase 0.0079 0.0265 0.026
Trichomonas vaginalis tubulin epsilon chain, putative 0.0996 0.4039 0.7448
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0019 0.0028
Brugia malayi hypothetical protein 0.0073 0.0243 0.0445
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0073
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0039 0.0101 0.0182
Loa Loa (eye worm) BEN-1 protein 0.1332 0.5422 1
Echinococcus granulosus intermediate filament protein 0.0028 0.0054 0.0092
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0097 0.0092
Echinococcus granulosus tyrosine protein kinase Src42A 0.0037 0.0092 0.0162
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.065 0.1192
Echinococcus multilocularis tyrosine protein kinase Blk 0.0042 0.0115 0.0111
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0101 0.0356 0.0649
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0132 0.024
Schistosoma mansoni hypothetical protein 0.0034 0.0079 0.0142
Echinococcus multilocularis cysteine protease 0.0017 0.0011 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0041 0.023
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.017 0.0639 0.1175
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0041 0.0112
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0152 0.0276
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0013
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0042 0.0115 0.0205
Plasmodium vivax glutathione reductase, putative 0.0048 0.014 0.0258
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0101 0.0356 0.0649
Brugia malayi tubulin alpha chain - mouse 0.0996 0.4039 0.7449
Onchocerca volvulus 0.0108 0.0384 0.2332
Onchocerca volvulus Protein patched homolog 0.0018 0.0015 0.0022
Loa Loa (eye worm) transcription factor SMAD2 0.036 0.1422 0.262
Trichomonas vaginalis tubulin, putative 0.1332 0.5422 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0119 0.022
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.0384 0.1354
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0048 0.0137 0.0785
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.0937 0.0933
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0041 0.0067
Brugia malayi hypothetical protein 0.0126 0.0457 0.0841
Echinococcus multilocularis tubulin alpha 1C chain 0.0996 0.4039 0.4036
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0048 0.0137 0.0785
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.0018
Mycobacterium ulcerans cell division protein FtsZ 0.0342 0.1349 1
Mycobacterium leprae Probable lipase LipE 0.0108 0.0384 0.262
Loa Loa (eye worm) hypothetical protein 0.0048 0.0137 0.0249
Trypanosoma brucei tubulin delta chain 0.0677 0.2726 0.5024
Toxoplasma gondii beta-1 tubulin, putative 0.1332 0.5422 1
Brugia malayi sulfakinin receptor protein 0.0229 0.0882 0.1623
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0097 0.0175
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0013
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0041 0.0075
Schistosoma mansoni tubulin subunit beta 0.1332 0.5422 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0219 0.0399
Leishmania major beta tubulin 0.1332 0.5422 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.001 0.001
Echinococcus multilocularis tubulin gamma 1 chain 0.0801 0.3238 0.3235
Trypanosoma cruzi MFS transporter, putative 0.0057 0.0176 0.032
Schistosoma mansoni integrin alpha-ps 0.0037 0.0091 0.0164
Giardia lamblia Epsilon tubulin 0.0396 0.1569 0.288
Entamoeba histolytica recQ family helicase, putative 0.0032 0.0072 0.0133
Echinococcus multilocularis tubulin alpha chain 0.0996 0.4039 0.4036
Trichomonas vaginalis DNA helicase recq, putative 0.0032 0.0072 0.0126
Echinococcus granulosus twitchin 0.0024 0.0042 0.0069
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0092 0.0161
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0019 0.002 0.0033
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0097 0.0092
Brugia malayi glutathione reductase 0.0048 0.014 0.0255
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0182 0.0329
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0119 0.0216
Toxoplasma gondii tubulin, putative 0.0053 0.0161 0.0292
Loa Loa (eye worm) hypothetical protein 0.0028 0.0055 0.0098
Brugia malayi Nuclear hormone receptor E75 0.0048 0.0137 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0091 0.0161
Loa Loa (eye worm) hypothetical protein 0.0048 0.0137 0.0249
Brugia malayi SPARC precursor 0.0039 0.0101 0.0184
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0054 0.0097
Loa Loa (eye worm) hypothetical protein 0.0039 0.0101 0.0184
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0297 0.1162 0.2144
Schistosoma mansoni organic anion transporter 0.0057 0.0176 0.032
Schistosoma mansoni nuclear receptor nhr-48 0.0048 0.0137 0.0248
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.065 0.1192
Loa Loa (eye worm) TK protein kinase 0.0042 0.0115 0.021
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Brugia malayi Integrin alpha pat-2 precursor 0.0156 0.0585 0.1076
Entamoeba histolytica protein kinase, putative 0.0035 0.0087 0.016
Echinococcus granulosus follistatin 0.0039 0.0101 0.0179
Loa Loa (eye worm) hypothetical protein 0.0101 0.0356 0.0653
Toxoplasma gondii protease inhibitor PI2 0.0039 0.0101 0.0182
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.1021 0.1878
Loa Loa (eye worm) tubulin alpha 2 0.0249 0.0965 0.1777
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.013 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0043 0.0071
Brugia malayi Steroid receptor seven-up type 2 0.0101 0.0356 0.0653
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0219 0.0401
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0132 0.024
Leishmania major beta tubulin 0.1332 0.5422 1
Leishmania major alpha tubulin 0.0996 0.4039 0.7448
Echinococcus granulosus tumor protein p63 0.0346 0.1364 0.2509
Toxoplasma gondii hypothetical protein 0.0018 0.0015 0.0023
Plasmodium vivax delta tubulin, putative 0.0342 0.1349 0.2488
Echinococcus granulosus integrin alpha ps 0.007 0.023 0.0416
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0007 0.0005
Schistosoma mansoni zinc finger protein 0.0048 0.0137 0.0248
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0065 0.0117
Loa Loa (eye worm) hypothetical protein 0.0053 0.016 0.0292
Schistosoma mansoni thyroid hormone receptor 0.023 0.0886 0.163
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0041 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0013
Brugia malayi hypothetical protein 0.0024 0.0041 0.0073
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.021 0.0382
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0025 0.0044 0.0123
Brugia malayi conserved hypotetical protein 0.0048 0.0137 0.0249
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0048 0.0137 0.0249
Loa Loa (eye worm) tubulin beta-1 chain 0.1332 0.5422 1
Schistosoma mansoni tyrosine kinase 0.0217 0.0832 0.1532
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0101 0.0356 0.0649
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Trypanosoma brucei hypothetical protein, conserved 0.0048 0.0137 0.0245
Leishmania major beta tubulin 0.1332 0.5422 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0044 0.0078
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0048 0.0137 0.0249
Toxoplasma gondii beta-tubulin, putative 0.1332 0.5422 1
Brugia malayi beta-lactamase family protein 0.0108 0.0384 0.0704
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Loa Loa (eye worm) hypothetical protein 0.0101 0.0356 0.0653
Trichomonas vaginalis tubulin epsilon chain, putative 0.0996 0.4039 0.7448
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0048 0.0137 0.0132
Toxoplasma gondii transporter, major facilitator family protein 0.0057 0.0176 0.032
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0039 0.0101 0.0182
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0061 0.011
Toxoplasma gondii thioredoxin reductase 0.0048 0.014 0.0254
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0025 0.0044 0.004
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0048 0.0137 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0041 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0013
Leishmania major cathepsin L-like protease 0.0065 0.021 0.0379
Loa Loa (eye worm) hypothetical protein 0.0057 0.0176 0.0321
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0079 0.0265 0.0488
Onchocerca volvulus 0.0057 0.0176 0.103
Trypanosoma cruzi beta tubulin, putative 0.1332 0.5422 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0219 0.0396
Loa Loa (eye worm) hypothetical protein 0.0035 0.0083 0.0151
Echinococcus multilocularis Tubulin alpha 1 chain 0.0996 0.4039 0.4036
Echinococcus multilocularis tumor protein p63 0.0346 0.1364 0.136
Brugia malayi PAS domain containing protein 0.005 0.0146 0.0266
Trichomonas vaginalis tubulin beta chain, putative 0.0996 0.4039 0.7448
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.013 0.0232
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0049 0.0141 0.0257
Loa Loa (eye worm) nuclear hormone receptor 0.0048 0.0137 0.0249
Echinococcus granulosus tubulin alpha chain 0.0996 0.4039 0.7448
Schistosoma mansoni integrin beta subunit 0.0189 0.0717 0.132
Loa Loa (eye worm) hypothetical protein 0.0048 0.0137 0.0249
Leishmania major beta tubulin 0.1332 0.5422 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0079 0.0265 0.0485
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0083 0.0151
Echinococcus multilocularis expressed protein 0.0039 0.0101 0.0097
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0092 0.0167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.013 0.0232
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0101 0.0356 0.0653
Trichomonas vaginalis tubulin epsilon chain, putative 0.1332 0.5422 1
Trypanosoma brucei tubulin gamma chain 0.0801 0.3238 0.5969
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.0014
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.001 0.001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.0384 0.0704
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0243 0.044
Schistosoma mansoni hypothetical protein 0.0123 0.0446 0.0819
Loa Loa (eye worm) beta-tubulin 0.1332 0.5422 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.013 0.0236
Brugia malayi ecdysteroid receptor 0.0101 0.0356 0.0653
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0025 0.0044 0.0081
Brugia malayi Cell division protein ftsZ 0.0342 0.1349 0.2486
Schistosoma mansoni agrin 0.0039 0.0101 0.0182
Onchocerca volvulus 0.0018 0.0015 0.0022
Plasmodium falciparum tubulin delta chain, putative 0.0342 0.1349 0.2474
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0079 0.0265 0.026
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.0114 0.0203
Schistosoma mansoni tyrosine kinase 0.0101 0.0358 0.0657
Echinococcus multilocularis Tubulin beta 2C chain 0.1332 0.5422 0.542
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0042 0.0069
Loa Loa (eye worm) hypothetical protein 0.0048 0.0137 0.0249
Loa Loa (eye worm) hypothetical protein 0.0101 0.0356 0.0653
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0048 0.0137 0.0249
Onchocerca volvulus 0.0037 0.0092 0.0508
Schistosoma mansoni hypothetical protein 0.0123 0.0446 0.0819
Echinococcus granulosus lamin dm0 0.0028 0.0054 0.0092
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.013 0.0236
Loa Loa (eye worm) hypothetical protein 0.0029 0.0061 0.011
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0007 0.0003
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0041 0.023
Onchocerca volvulus 0.0108 0.0384 0.2332
Trypanosoma brucei epsilon tubulin 0.0747 0.3015 0.5558
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0021 0.0029 0.0025
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0025 0.0042 0.0073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Brugia malayi MH1 domain containing protein 0.0025 0.0042 0.0074
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0104 0.037 0.0676
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0039 0.0101 0.0184
Loa Loa (eye worm) hypothetical protein 0.0101 0.0356 0.0653
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0011 0.0017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.0014
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0079 0.0265 0.048
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0101 0.0356 0.0653
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0101 0.0356 0.0352
Loa Loa (eye worm) MH2 domain-containing protein 0.036 0.1422 0.262
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.021 0.0379
Brugia malayi hypothetical protein 0.0242 0.0937 0.1725
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0073
Mycobacterium ulcerans lipase LipD 0.0108 0.0384 0.279
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0074
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0166 0.0303
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0101 0.0356 0.0652
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0079 0.0265 0.048
Echinococcus granulosus neuropeptide s receptor 0.0482 0.1925 0.3545
Echinococcus granulosus Tubulin beta 2C chain 0.1332 0.5422 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0224 0.0861 0.1581
Schistosoma mansoni follistatin 0.0039 0.0101 0.0182
Echinococcus granulosus fibroblast growth factor receptor 4 0.0107 0.0379 0.0692
Brugia malayi eukaryotic initiation factor 4A 0.0025 0.0044 0.0078
Echinococcus granulosus tubulin beta 1 chain 0.1332 0.5422 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0996 0.4039 0.7448
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0149 0.0273
Loa Loa (eye worm) TK/ABL protein kinase 0.0224 0.0861 0.1585
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.013 0.0237
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0101 0.0356 0.0653
Brugia malayi Patched family protein 0.0018 0.0015 0.0024
Brugia malayi hypothetical protein 0.0057 0.0176 0.0321
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0072 0.0126
Brugia malayi hypothetical protein 0.0081 0.0274 0.0503
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.003 0.0048
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Loa Loa (eye worm) hypothetical protein 0.0591 0.2373 0.4375
Leishmania major hypothetical protein, conserved 0.0108 0.0384 0.07
Echinococcus multilocularis hypothetical protein 0.0996 0.4039 0.4036
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0072
Schistosoma mansoni nuclear hormone receptor 0.0048 0.0137 0.0248
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Echinococcus multilocularis roundabout 2 0.0031 0.0066 0.0062
Giardia lamblia Beta tubulin 0.1332 0.5422 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0013
Schistosoma mansoni tyrosine kinase 0.0162 0.0609 0.1119
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0008
Loa Loa (eye worm) hypoxia-induced factor 1 0.0154 0.0575 0.1057
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0101 0.0356 0.0653
Loa Loa (eye worm) hypothetical protein 0.0108 0.0384 0.0704
Onchocerca volvulus 0.0108 0.0384 0.2332
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.0384 0.1354
Plasmodium falciparum glutathione reductase 0.0048 0.014 0.024
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0011 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0011 0.0013
Loa Loa (eye worm) tubulin alpha chain 0.0996 0.4039 0.7449
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0011 0.0021
Schistosoma mansoni smad1 5 8 and 0.0025 0.0042 0.0073
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0185 0.0337
Loa Loa (eye worm) hypothetical protein 0.0101 0.0356 0.0653
Brugia malayi hypothetical protein 0.0048 0.0137 0.0249
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0008
Loa Loa (eye worm) integrin alpha pat-2 0.0241 0.0933 0.1719
Brugia malayi MH2 domain containing protein 0.0025 0.0042 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0101 0.0356 0.0653
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.0471 0.0467
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0056 0.0173 0.0168
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0079 0.0265 0.026
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0048 0.0137 0.1001
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0039 0.0101 0.0184
Brugia malayi SRC-1 0.0049 0.0143 0.0261
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0048 0.0137 0.0951
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0104 0.0193
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0011 0.0007
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.0384 0.279
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0132 0.0236
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0101 0.0356 0.0652
Echinococcus granulosus tubulin epsilon chain 0.0801 0.3235 0.5963
Brugia malayi beta-lactamase 0.0108 0.0384 0.0704
Treponema pallidum cell division protein FtsZ 0.0342 0.1349 1
Schistosoma mansoni alpha tubulin 0.0996 0.4039 0.7449
Brugia malayi Isocitrate dehydrogenase 0.0079 0.0265 0.0485
Schistosoma mansoni hypothetical protein 0.0123 0.0446 0.0819
Echinococcus multilocularis ecdysone induced protein 78C 0.0101 0.0356 0.0352
Schistosoma mansoni tubulin subunit alpha 0.0996 0.4039 0.7449
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0013
Schistosoma mansoni tubulin subunit beta 0.1332 0.5422 1
Brugia malayi Tyrosine-protein kinase abl-1 0.01 0.0352 0.0647
Leishmania major beta tubulin 0.1332 0.5422 1
Loa Loa (eye worm) Smad1 0.0025 0.0042 0.0074
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.021 0.0382
Brugia malayi hypothetical protein 0.0048 0.0137 0.0249
Mycobacterium leprae conserved hypothetical protein 0.0048 0.0137 0.0737
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.0446 0.3096
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0007 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0384 0.07
Loa Loa (eye worm) hypothetical protein 0.0051 0.0149 0.0272
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0013
Loa Loa (eye worm) cysteine protease 0.0017 0.0011 0.0018
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0182 0.0329
Plasmodium vivax patched family protein, putative 0.0018 0.0015 0.0028
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.0446 0.158
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0119 0.0216
Echinococcus multilocularis dnaJ subfamily B 0.0419 0.1663 0.1659
Loa Loa (eye worm) hypothetical protein 0.0034 0.0079 0.0143
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0049 0.0143 0.0139
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0243 0.0239
Leishmania major trypanothione reductase 0.0048 0.014 0.025
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0082 0.0146
Brugia malayi MH2 domain containing protein 0.0025 0.0042 0.0074
Echinococcus granulosus Tubulin beta 2C chain 0.1332 0.5422 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0072 0.0129
Brugia malayi hypothetical protein 0.0053 0.016 0.0292
Mycobacterium ulcerans beta-lactamase 0.0108 0.0384 0.279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0082 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0102 0.0181
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0007 0.0003
Trichomonas vaginalis tubulin alpha chain, putative 0.0405 0.1607 0.2958
Trichomonas vaginalis tubulin alpha chain, putative 0.0405 0.1607 0.2958
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Giardia lamblia Sgs1 DNA helicase, putative 0.0029 0.0061 0.0095
Echinococcus multilocularis epidermal growth factor receptor 0.0309 0.1213 0.1209
Echinococcus multilocularis tubulin subunit beta 0.1332 0.5422 0.542
Brugia malayi Integrin beta pat-3 precursor 0.0321 0.126 0.2321
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0384 0.0707
Echinococcus granulosus tubulin alpha chain 0.0996 0.4039 0.7448
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0119 0.0212
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.021 0.0382
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0042 0.0115 0.0111
Echinococcus multilocularis epidermal growth factor receptor 0.0168 0.0632 0.0628
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0101 0.0356 0.0652
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0048 0.0137 0.0132
Echinococcus granulosus tm gpcr rhodopsin 0.0541 0.2167 0.3992
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0092 0.0161
Loa Loa (eye worm) hypothetical protein 0.0048 0.0137 0.0249
Echinococcus granulosus Tubulin beta 2C chain 0.1332 0.5422 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0042 0.0037
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0101 0.0356 0.2158
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0104 0.0175
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.013 0.024
Entamoeba histolytica tubulin family protein 0.1332 0.5422 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.003 0.0065 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0082 0.0143
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0396 0.1569 0.289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0082 0.0143
Schistosoma mansoni tyrosine kinase 0.0049 0.0143 0.026
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0048 0.0137 0.0244
Brugia malayi sodium-independent organic anion transporter family protein 0.0057 0.0176 0.0321
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0025 0.0044 0.0077
Schistosoma mansoni hypothetical protein 0.0049 0.0144 0.0261
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.005
Brugia malayi Patched family protein 0.0018 0.0015 0.0024
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0015 0.002
Loa Loa (eye worm) tubulin alpha-2 chain 0.0996 0.4039 0.7449
Echinococcus granulosus single minded 2 0.0037 0.0092 0.0163
Onchocerca volvulus 0.017 0.0639 0.3932
Echinococcus multilocularis c src tyrosine kinase 0.0019 0.002 0.0016
Leishmania major alpha tubulin 0.0996 0.4039 0.7448
Schistosoma mansoni hypothetical protein 0.0129 0.0471 0.0865
Echinococcus multilocularis cysteine protease 0.0017 0.0011 0.0007
Echinococcus granulosus insulin receptor 0.0101 0.0358 0.0653
Echinococcus multilocularis tubulin alpha chain 0.0996 0.4039 0.4036
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0104 0.037 0.0366
Echinococcus multilocularis tubulin alpha 0.0747 0.3015 0.3012
Trypanosoma cruzi PAB1-binding protein , putative 0.0126 0.0457 0.084
Echinococcus granulosus thyroid hormone receptor alpha 0.0048 0.0137 0.0244
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0149 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0043 0.0071
Schistosoma mansoni smad 0.0025 0.0042 0.0073
Echinococcus granulosus peroxisome assembly protein 26 0.0996 0.4039 0.7448
Plasmodium falciparum alpha tubulin 2 0.0996 0.4039 0.7445
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0182 0.0625
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0048 0.0137 0.0461
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0168 0.0632 0.1158
Brugia malayi nuclear hormone receptor 0.0101 0.0356 0.0653
Echinococcus multilocularis Niemann Pick C1 protein 0.0424 0.1686 0.1683
Echinococcus granulosus GPCR family 2 0.0016 0.0007 0.0005
Schistosoma mansoni hypothetical protein 0.0056 0.0173 0.0314
Loa Loa (eye worm) hypothetical protein 0.0108 0.0384 0.0704
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0143 0.0139
Toxoplasma gondii patched family protein 0.0018 0.0015 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0013
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0182 0.1289
Loa Loa (eye worm) hypothetical protein 0.0051 0.0149 0.0273
Loa Loa (eye worm) steroid hormone receptor 0.0101 0.0356 0.0653
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.0395 0.1396
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0029 0.0061 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.0014
Schistosoma mansoni steroid hormone receptor ad4bp 0.0101 0.0356 0.0652
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.065 0.1192
Loa Loa (eye worm) alpha-tubulin 0.0996 0.4039 0.7449
Onchocerca volvulus 0.0024 0.0041 0.0184
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0079 0.0265 0.048
Echinococcus granulosus tubulin gamma 1 chain 0.0801 0.3238 0.5969
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0004 0.0005
Schistosoma mansoni organic anion transporter 0.0057 0.0176 0.032
Echinococcus multilocularis FTZ F1 alpha 0.0101 0.0356 0.0352
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0049 0.0143 0.0139
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0025 0.0044 0.0204
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0182 0.1289
Brugia malayi hypothetical protein 0.0018 0.0015 0.0024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0132 0.0128
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0056 0.0173 0.031
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0092 0.0088
Entamoeba histolytica tubulin family protein 0.1332 0.5422 1
Trypanosoma brucei PAB1-binding protein , putative 0.0126 0.0457 0.0836
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Echinococcus granulosus tubulin alpha 1C chain 0.0996 0.4039 0.7448
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0013
Trypanosoma brucei epsilon tubulin 0.0801 0.3235 0.5963
Leishmania major alpha tubulin 0.0996 0.4039 0.7448
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0108 0.0384 0.0704
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0079 0.0265 0.0923
Echinococcus multilocularis Tubulin beta 2C chain 0.1332 0.5422 0.542
Echinococcus granulosus Nuclear hormone receptor HR96 0.0048 0.0137 0.0244
Brugia malayi Fibronectin type III domain containing protein 0.0024 0.0041 0.0073
Leishmania major zeta tubulin, putative 0.0902 0.3651 0.6731
Trichomonas vaginalis tubulin beta chain, putative 0.0996 0.4039 0.7448
Schistosoma mansoni cpg binding protein 0.0031 0.0069 0.0122
Leishmania major alpha tubulin 0.0996 0.4039 0.7448
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0092 0.0617
Schistosoma mansoni hypothetical protein 0.0073 0.0243 0.0444
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.021 0.0379
Brugia malayi Niemann-Pick C1 protein precursor 0.0297 0.1162 0.2141
Echinococcus multilocularis agrin 0.0039 0.0101 0.0097
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0092 0.0165
Brugia malayi Patched family protein 0.0018 0.0015 0.0024
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0011 0.0018
Echinococcus granulosus neuropeptide receptor A26 0.0482 0.1925 0.3545
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.021 0.0379
Schistosoma mansoni tubulin subunit gamma 0.0801 0.3238 0.5971
Echinococcus multilocularis tubulin alpha chain 0.0996 0.4039 0.4036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0082 0.0143
Echinococcus multilocularis tyrosine protein kinase Abl 0.01 0.0352 0.0348
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0097 0.0174
Trypanosoma cruzi alpha tubulin, putative 0.0996 0.4039 0.7449
Leishmania major alpha tubulin 0.0996 0.4039 0.7448
Schistosoma mansoni tubulin subunit alpha 0.0996 0.4039 0.7449
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0101 0.0356 0.0653
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0118 0.0428 0.0786
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0048 0.0137 0.0244
Trichomonas vaginalis DNA helicase recq1, putative 0.0042 0.0114 0.0203
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0101 0.0356 0.0352
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.021 0.0379
Echinococcus granulosus c src tyrosine kinase 0.0019 0.002 0.003
Echinococcus granulosus tyrosine protein kinase Fyn 0.0049 0.0143 0.0256
Brugia malayi Protein kinase domain containing protein 0.0101 0.0358 0.0658
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0054 0.0097
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0011 0.0018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.0014
Echinococcus granulosus beta tubulin 0.1332 0.5422 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0043 0.0071
Plasmodium vivax tubulin epsilon chain, putative 0.0801 0.3235 0.5966
Echinococcus granulosus Niemann Pick C1 protein 0.0424 0.1686 0.3105
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0097 0.017
Schistosoma mansoni nephrin 0.0027 0.0054 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0054 0.0092
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.1021 0.1878
Schistosoma mansoni tubulin subunit alpha 0.0342 0.1349 0.2485
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0013
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0011 0.0007
Brugia malayi nuclear receptor NHR-88 0.0101 0.0356 0.0653
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0384 0.0703
Trichomonas vaginalis tubulin, putative 0.0405 0.1607 0.2958
Plasmodium falciparum tubulin epsilon chain, putative 0.0801 0.3235 0.5959
Onchocerca volvulus 0.0057 0.0176 0.103
Giardia lamblia GTOR 0.0046 0.013 0.0222
Leishmania major eukaryotic initiation factor 4a, putative 0.0025 0.0044 0.0073
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0025 0.0044 0.0073
Echinococcus multilocularis integrin alpha ps 0.007 0.023 0.0225
Echinococcus multilocularis smad 0.0025 0.0042 0.0037
Schistosoma mansoni single-minded 0.005 0.0146 0.0265
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0007 0.0005
Brugia malayi Patched family protein 0.0018 0.0015 0.0024
Brugia malayi Tubulin alpha-2 chain 0.0996 0.4039 0.7449
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0048 0.0137 0.0249
Onchocerca volvulus 0.0018 0.0015 0.0022
Schistosoma mansoni tyrosine kinase 0.0049 0.0143 0.026
Echinococcus multilocularis GPCR, family 2 0.0016 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.005
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0042 0.0074
Schistosoma mansoni tyrosine kinase 0.0309 0.1213 0.2234
Loa Loa (eye worm) hypothetical protein 0.0048 0.0137 0.0249
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0107 0.0379 0.0692
Plasmodium falciparum alpha tubulin 1 0.0996 0.4039 0.7445
Schistosoma mansoni tubulin subunit beta 0.1332 0.5422 1
Schistosoma mansoni hypothetical protein 0.0106 0.0376 0.069
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0747 0.3015 0.5559
Trypanosoma brucei zeta tubulin, putative 0.0902 0.3651 0.6731
Brugia malayi Patched family protein 0.0018 0.0015 0.0024
Schistosoma mansoni tubulin subunit epsilon 0.0801 0.3235 0.5965
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0101 0.0356 0.0652
Loa Loa (eye worm) integrin beta-2 0.0321 0.126 0.2321
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0048 0.0137 0.0951
Trypanosoma brucei alpha tubulin 0.0996 0.4039 0.7448
Loa Loa (eye worm) hypothetical protein 0.0126 0.0457 0.0841
Schistosoma mansoni coup transcription factor 0.0101 0.0356 0.0652
Brugia malayi Myosin head containing protein 0.0018 0.0015 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Leishmania major cathepsin L-like protease 0.0017 0.0011 0.0013
Echinococcus multilocularis musashi 0.0028 0.0054 0.005
Loa Loa (eye worm) RecQ helicase 0.0042 0.0114 0.0207
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0146 0.0265
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0041 0.0075
Loa Loa (eye worm) patched family protein 0.0018 0.0015 0.0024
Brugia malayi Patched family protein 0.0018 0.0015 0.0024
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.001 0.0014
Brugia malayi intermediate filament protein 0.0028 0.0054 0.0097
Trypanosoma brucei beta tubulin 0.1332 0.5422 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0137 0.0249
Entamoeba histolytica tubulin gamma chain 0.0801 0.3238 0.5972
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0101 0.0356 0.0653
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Loa Loa (eye worm) TK protein kinase 0.0035 0.0087 0.0157
Trichomonas vaginalis tubulin alpha chain, putative 0.0747 0.3015 0.5558
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0654 0.2631 0.4851
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.001 0.001
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0049 0.0143 0.0139
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0061 0.0109
Brugia malayi Nuclear hormone receptor-like 1 0.0101 0.0356 0.0653
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0013
Echinococcus multilocularis beta tubulin 0.1332 0.5422 0.542
Loa Loa (eye worm) hypothetical protein 0.0101 0.0356 0.0653
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0039 0.0101 0.0182
Loa Loa (eye worm) tubulin alpha 2 0.0654 0.2631 0.4851
Onchocerca volvulus Protein patched homolog 0.0018 0.0015 0.0022
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0011 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0013
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0048 0.0137 0.0253
Onchocerca volvulus 0.0057 0.0176 0.103
Brugia malayi hypothetical protein 0.0018 0.0015 0.0024
Loa Loa (eye worm) tubulin beta chain 0.0342 0.1349 0.2486
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0053 0.016 0.0287
Loa Loa (eye worm) BEN-1 protein 0.1332 0.5422 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0011 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.065 0.1192
Echinococcus granulosus integrin alpha ps 0.0034 0.0079 0.0138
Brugia malayi secreted modular calcium-binding protein 1 0.0039 0.0101 0.0184
Brugia malayi Tubulin beta-1 chain 0.1332 0.5422 1
Echinococcus granulosus L aminoadipate semialdehyde 0.017 0.0639 0.1171
Loa Loa (eye worm) hypothetical protein 0.0028 0.0054 0.0097
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Brugia malayi CHE-14 protein 0.0127 0.0465 0.0855
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0048 0.0137 0.0248
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.065 0.1192
Schistosoma mansoni tyrosine kinase 0.0162 0.0609 0.1119
Schistosoma mansoni cell adhesion molecule 0.0027 0.0054 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0043 0.0071
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0224 0.0861 0.0857
Leishmania major beta tubulin 0.1332 0.5422 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Brugia malayi protein C24B5.3 0.0018 0.0015 0.0024
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.1021 0.1878
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.021 0.0379
Echinococcus granulosus defective proboscis extension response 0.0021 0.0029 0.0046
Trichomonas vaginalis tubulin beta chain, putative 0.1332 0.5422 1
Trichomonas vaginalis tubulin beta chain, putative 0.0996 0.4039 0.7448
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0101 0.0356 0.0653
Brugia malayi hypothetical protein 0.0167 0.0628 0.1156
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0008
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0053 0.016 0.0292
Echinococcus granulosus tubulin alpha 0.0747 0.3015 0.5558
Loa Loa (eye worm) hypothetical protein 0.0229 0.0882 0.1623
Trichomonas vaginalis tubulin beta chain, putative 0.0996 0.4039 0.7448
Brugia malayi CXXC zinc finger family protein 0.0029 0.0062 0.0111
Echinococcus multilocularis nuclear receptor nhr 48 0.0048 0.0137 0.0132
Leishmania major beta tubulin 0.1332 0.5422 1
Onchocerca volvulus 0.0039 0.0101 0.0563
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0101 0.0356 0.0653
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0011 0.0006
Leishmania major alpha tubulin 0.0996 0.4039 0.7448
Echinococcus multilocularis neuropeptide receptor A26 0.0482 0.1925 0.1921
Loa Loa (eye worm) hypothetical protein 0.0048 0.0137 0.0249
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0219 0.0401
Brugia malayi Patched family protein 0.0018 0.0015 0.0024
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0025 0.0044 0.0077
Loa Loa (eye worm) ctsf protein 0.0017 0.0011 0.0018
Schistosoma mansoni tubulin subunit alpha 0.0996 0.4039 0.7449
Schistosoma mansoni nuclear hormone receptor 0.0101 0.0356 0.0652
Trichomonas vaginalis conserved hypothetical protein 0.0127 0.0465 0.085
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0025 0.0044 0.0077
Echinococcus multilocularis expressed conserved protein 0.0279 0.1088 0.1084
Echinococcus multilocularis integrin alpha ps 0.0034 0.0079 0.0075
Loa Loa (eye worm) hypothetical protein 0.0039 0.0101 0.0184
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.001 0.0006
Trichomonas vaginalis tubulin gamma chain, putative 0.0342 0.1349 0.2482
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0101 0.0356 0.0352
Echinococcus multilocularis protein patched 0.0127 0.0465 0.0461
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0219 0.0404
Brugia malayi Tubulin alpha chain 0.0342 0.1349 0.2486
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0097 0.0174
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0013
Schistosoma mansoni intermediate filament proteins 0.0028 0.0054 0.0096
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.001 0.001
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.013 0.0232
Echinococcus multilocularis tubulin alpha 1C chain 0.0996 0.4039 0.4036
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0654 0.2631 0.4849
Schistosoma mansoni cpg binding protein 0.0031 0.0069 0.0122
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.0471 0.0861
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0097 0.017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0011 0.0006
Mycobacterium leprae conserved hypothetical protein 0.0108 0.0384 0.262
Onchocerca volvulus Putative organic anion transporter 0.0057 0.0176 0.103
Echinococcus multilocularis tubulin delta chain 0.0342 0.1349 0.1345
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0004 0.0004
Echinococcus multilocularis sterol regulatory element binding protein 0.0127 0.0465 0.0461
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0041 0.023
Leishmania major cathepsin L-like protease 0.0065 0.021 0.0379
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0061 0.011
Onchocerca volvulus 0.0028 0.0054 0.027
Echinococcus granulosus tyrosine protein kinase Src64B 0.0049 0.0143 0.0256
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.1021 0.1878
Leishmania major alpha tubulin 0.0996 0.4039 0.7448
Loa Loa (eye worm) tubulin beta chain 0.1332 0.5422 1
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0688 0.1262
Leishmania major alpha tubulin 0.0996 0.4039 0.7448
Trichomonas vaginalis tubulin, putative 0.0396 0.1572 0.2894
Loa Loa (eye worm) hypothetical protein 0.0037 0.0091 0.0165
Echinococcus granulosus tubulin delta chain 0.0342 0.1349 0.2482
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0013
Schistosoma mansoni survival motor neuron protein 0.0049 0.0144 0.0261
Schistosoma mansoni hypothetical protein 0.0419 0.1663 0.3064
Loa Loa (eye worm) hypothetical protein 0.0049 0.0141 0.0257
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.014 0.0136
Leishmania major beta tubulin 0.1332 0.5422 1
Echinococcus granulosus tubulin alpha chain 0.0996 0.4039 0.7448
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0384 0.07
Schistosoma mansoni smad1 5 8 and 0.0025 0.0042 0.0073
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0057 0.0176 0.0321
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.0547 0.0543
Mycobacterium tuberculosis Conserved protein 0.0108 0.0384 0.1354
Leishmania major beta tubulin 0.1332 0.5422 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0064 0.011
Echinococcus multilocularis neuroglian 0.0024 0.0042 0.0037
Trypanosoma brucei epsilon tubulin 0.0801 0.3235 0.5963
Loa Loa (eye worm) fibroinase 0.0017 0.0011 0.0018
Toxoplasma gondii isocitrate dehydrogenase 0.0079 0.0265 0.0484
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0011 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0101 0.0356 0.0653
Echinococcus granulosus tyrosine protein kinase Fyn 0.0049 0.0143 0.0256
Loa Loa (eye worm) hypothetical protein 0.0086 0.0296 0.0543
Trichomonas vaginalis tubulin beta chain, putative 0.0996 0.4039 0.7448
Brugia malayi tailless protein 0.0048 0.0137 0.0249
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0182 0.0332
Onchocerca volvulus Putative organic anion transporter 0.0057 0.0176 0.103
Brugia malayi ecdysone receptor 0.0048 0.0137 0.0249
Schistosoma mansoni cpg binding protein 0.0029 0.0062 0.011
Toxoplasma gondii alpha tubulin TUBA1 0.0996 0.4039 0.7449
Brugia malayi beta-lactamase family protein 0.0108 0.0384 0.0704
Schistosoma mansoni tyrosine kinase 0.0107 0.0379 0.0695
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.021 0.0379
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0013
Brugia malayi Patched related family protein 4 0.0018 0.0015 0.0024
Brugia malayi orphan nuclear receptor NR2E1 0.0048 0.0137 0.0249
Giardia lamblia Beta tubulin 0.1332 0.5422 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0072 0.0126
Echinococcus multilocularis peroxisome assembly protein 26 0.0996 0.4039 0.4036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0068 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0342 0.1349 0.2482
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.0395 0.2708
Brugia malayi tubulin alpha-2 chain 0.0996 0.4039 0.7449
Schistosoma mansoni lamin 0.0028 0.0054 0.0096
Loa Loa (eye worm) hypothetical protein 0.0028 0.0054 0.0097
Echinococcus granulosus Tubulin beta 2C chain 0.1332 0.5422 1
Echinococcus granulosus tubulin alpha chain 0.0996 0.4039 0.7448
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.065 0.1192
Trypanosoma brucei alpha tubulin 0.0996 0.4039 0.7448
Treponema pallidum NADH oxidase 0.0017 0.001 0.0056
Loa Loa (eye worm) TK/INSR protein kinase 0.0101 0.0358 0.0658
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0029 0.0061 0.011
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.001 0.001
Mycobacterium tuberculosis Probable reductase 0.011 0.0395 0.1396
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0202 0.0771 0.1415
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.0384 0.1354
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0097 0.016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0015 0.0029
Echinococcus multilocularis Immunoglobulin 0.0021 0.0029 0.0025
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.013 0.0236
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Toxoplasma gondii beta tubulin 0.1332 0.5422 1
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.065 0.4002
Brugia malayi nuclear hormone receptor 0.0048 0.0137 0.0249
Brugia malayi Nuclear hormone receptor E75 0.0048 0.0137 0.0249
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0101 0.0356 0.0653
Entamoeba histolytica hypothetical protein 0.0073 0.0243 0.0448
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0025 0.0044 0.004
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0062 0.0111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.021 0.0379
Echinococcus multilocularis beta tubulin 0.1332 0.5422 0.542
Echinococcus multilocularis integrin alpha ps 0.007 0.023 0.0225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0013
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0119 0.0212
Leishmania major alpha tubulin 0.0996 0.4039 0.7448
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0219 0.0215
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0025 0.0044 0.0081
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.001
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.001 0.0014
Brugia malayi Tubulin beta chain 0.0342 0.1349 0.2486
Brugia malayi sodium-independent organic anion transporter family protein 0.0057 0.0176 0.0321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0043 0.0071
Brugia malayi Patched protein homolog 1 0.0018 0.0015 0.0024
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0011 0.0018
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0079 0.0265 0.0484
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0132 0.0241
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0144 0.0262
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0132 0.0236
Brugia malayi Patched family protein 0.0018 0.0015 0.0024
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0104 0.0175
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.014 0.0258
Loa Loa (eye worm) hypothetical protein 0.0108 0.0384 0.0704
Brugia malayi Bloom's syndrome protein homolog 0.0042 0.0114 0.0207
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0219 0.0399
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0041 0.0072
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0072
Schistosoma mansoni RAR-like nuclear receptor 0.0101 0.0356 0.0652
Echinococcus granulosus geminin 0.0844 0.3413 0.6291
Loa Loa (eye worm) tubulin alpha chain 0.0996 0.4039 0.7449
Schistosoma mansoni retinoic acid receptor RXR 0.0202 0.0771 0.1418
Giardia lamblia Beta tubulin 0.1332 0.5422 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0101 0.0356 0.0652
Echinococcus granulosus bloom syndrome protein 0.0042 0.0114 0.0203
Giardia lamblia Alpha-tubulin 0.0996 0.4039 0.7445
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0011 0.0003
Brugia malayi Patched family protein 0.0018 0.0015 0.0024
Echinococcus multilocularis lamin dm0 0.0028 0.0054 0.005
Schistosoma mansoni tubulin subunit delta 0.0342 0.1349 0.2485
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0384 0.0703
Trichomonas vaginalis tubulin gamma chain, putative 0.1332 0.5422 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.016 0.0292
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0004 0.0004
Brugia malayi nuclear receptor NHR-88 0.0048 0.0137 0.0249
Trichomonas vaginalis tubulin beta chain, putative 0.0996 0.4039 0.7448
Echinococcus multilocularis tyrosine protein kinase HCK 0.0035 0.0087 0.0082
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Brugia malayi MH1 domain containing protein 0.0025 0.0042 0.0074
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0101 0.0356 0.0649
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0041 0.023
Toxoplasma gondii patched family protein 0.0018 0.0015 0.0023
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.001 0.0018
Loa Loa (eye worm) patched family protein 0.0018 0.0015 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.021 0.0379
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0024
Echinococcus granulosus tyrosine protein kinase Src42A 0.0049 0.0143 0.0256
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0053 0.016 0.0156
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0025
Brugia malayi steroid hormone receptor 0.0101 0.0356 0.0653
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.0395 0.1396
Trypanosoma cruzi zeta tubulin, putative 0.0902 0.3651 0.6732
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0013
Onchocerca volvulus 0.0018 0.0015 0.0022
Schistosoma mansoni tyrosine kinase 0.0168 0.0632 0.1161
Echinococcus granulosus sterol regulatory element binding protein 0.0127 0.0465 0.085
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.1021 0.1878
Brugia malayi nuclear hormone receptor family member nhr-6 0.0048 0.0137 0.0249
Echinococcus multilocularis tubulin alpha 3 chain 0.0996 0.4039 0.4036
Brugia malayi Tubulin alpha chain 0.0996 0.4039 0.7449
Loa Loa (eye worm) hypothetical protein 0.0127 0.0465 0.0855
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0219 0.0399
Echinococcus granulosus Immunoglobulin 0.0021 0.0029 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.021 0.0379
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0001
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0025 0.0044 0.0073
Schistosoma mansoni nuclear hormone receptor 0.0048 0.0137 0.0248

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.6109 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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