Detailed information for compound 153038

Basic information

Technical information
  • TDR Targets ID: 153038
  • Name: methyl 3-butanoyl-4-(2-methylanilino)quinolin e-8-carboxylate
  • MW: 362.422 | Formula: C22H22N2O3
  • H donors: 1 H acceptors: 3 LogP: 5.01 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(=O)c1cnc2c(c1Nc1ccccc1C)cccc2C(=O)OC
  • InChi: 1S/C22H22N2O3/c1-4-8-19(25)17-13-23-20-15(10-7-11-16(20)22(26)27-3)21(17)24-18-12-6-5-9-14(18)2/h5-7,9-13H,4,8H2,1-3H3,(H,23,24)
  • InChiKey: WABJVWVNEPAILL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2-methylanilino)-3-(1-oxobutyl)-8-quinolinecarboxylic acid methyl ester
  • methyl 3-butanoyl-4-[(2-methylphenyl)amino]quinoline-8-carboxylate
  • 3-butyryl-4-(o-toluidino)quinoline-8-carboxylic acid methyl ester
  • 4-[(2-methylphenyl)amino]-3-(1-oxobutyl)-8-quinolinecarboxylic acid methyl ester
  • 3-butyryl-4-[(2-methylphenyl)amino]quinoline-8-carboxylic acid methyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Potassium-transporting ATPase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Potassium-transporting ATPase   290 aa 306 aa 26.1 %
Echinococcus multilocularis nervana 2 Potassium-transporting ATPase   290 aa 280 aa 29.6 %
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 266 aa 24.1 %
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Potassium-transporting ATPase   290 aa 267 aa 21.3 %
Echinococcus multilocularis nervana 2 Potassium-transporting ATPase   290 aa 265 aa 22.3 %
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Potassium-transporting ATPase   290 aa 254 aa 23.6 %
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 267 aa 27.3 %
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Potassium-transporting ATPase   290 aa 258 aa 24.4 %
Onchocerca volvulus Glutamate carboxypeptidase 2 homolog Potassium-transporting ATPase   290 aa 301 aa 25.9 %
Drosophila melanogaster nervana 1 Potassium-transporting ATPase   290 aa 305 aa 23.9 %
Echinococcus granulosus nervana 2 Potassium-transporting ATPase   290 aa 280 aa 29.3 %
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 266 aa 25.6 %
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta, putative Potassium-transporting ATPase   290 aa 256 aa 25.4 %
Schistosoma japonicum ko:K01540 Na+/K+-exchanging ATPase beta subunit [EC3.6.3.9B], putative Potassium-transporting ATPase   290 aa 258 aa 23.6 %
Loa Loa (eye worm) hypothetical protein Potassium-transporting ATPase   290 aa 301 aa 25.9 %
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 267 aa 27.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.041 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.087 0.087
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.001 0.0052 0.0052
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.001 0.0052 0.0052
Echinococcus granulosus serotonin transporter 0.0318 0.7729 0.7729
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0054 0.1141 0.2348
Echinococcus multilocularis partitioning defective 3 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0054 0.1141 0.1141
Loa Loa (eye worm) hypothetical protein 0.0318 0.7729 0.7729
Brugia malayi C2 domain containing protein 0.001 0.0052 0.0052
Brugia malayi microtubule-associated serine/threonine protein kinase 2 (MAST2) 0.001 0.0052 0.0052
Leishmania major nitrate reductase, putative 0.0047 0.0954 0.0954
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0047 0.0954 0.0954
Loa Loa (eye worm) gopc protein 0.001 0.0052 0.0052
Schistosoma mansoni maguk P55 subfamily member 26 0.001 0.0052 0.0052
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.041 1 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0026 0.0433 0.0433
Brugia malayi Abnormal embryonic partitioning of cytoplasm protein 3 0.001 0.0052 0.0052
Brugia malayi PDZ domain 0.001 0.0052 0.0052
Schistosoma mansoni discs lost-related 0.001 0.0052 0.0052
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0017 0.0218 0.0506
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0047 0.0954 0.0954
Plasmodium vivax hypothetical protein, conserved 0.0054 0.1141 0.0943
Chlamydia trachomatis sulfite reductase 0.0253 0.6096 1
Echinococcus granulosus MAGUK p55 subfamily 0.001 0.0052 0.0052
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0017 0.0218 0.0218
Echinococcus granulosus membrane associated guanylate kinase, WW and PDZ 0.001 0.0052 0.0052
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0047 0.0954 0.0954
Treponema pallidum sodium- and chloride- dependent transporter 0.0318 0.7729 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Loa Loa (eye worm) RasGEF domain-containing protein 0.001 0.0052 0.0052
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0026 0.0433 0.0433
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0017 0.0218 0.0212
Brugia malayi flavodoxin family protein 0.0157 0.3698 0.3698
Echinococcus granulosus sodium and chloride dependent glycine 0.0054 0.1141 0.1141
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.087 0.087
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0969 0.0969
Trypanosoma brucei nitrate reductase, putative 0.0047 0.0954 0.0954
Loa Loa (eye worm) hypothetical protein 0.0054 0.1141 0.1141
Entamoeba histolytica type A flavoprotein, putative 0.0157 0.3698 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0218 0.0212
Trichomonas vaginalis cation-transporting ATPase, putative 0.0017 0.0218 0.0212
Onchocerca volvulus 0.0026 0.0433 0.0496
Brugia malayi PX domain containing protein 0.001 0.0052 0.0052
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0054 0.1141 0.1141
Brugia malayi Partitioning defective-6 homolog alpha 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Echinococcus multilocularis nervana 2 0.0026 0.0433 0.0433
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0014 0.0133 0.0133
Schistosoma mansoni pdz and lim domain protein 0.001 0.0052 0.0052
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0047 0.0954 0.0954
Echinococcus multilocularis multiple pdz domain protein 0.001 0.0052 0.0052
Trichomonas vaginalis cation-transporting ATPase, putative 0.0017 0.0218 0.0212
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0157 0.3698 0.3698
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0026 0.0433 0.0433
Mycobacterium tuberculosis Probable monooxygenase 0.0047 0.0954 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0006 0.0006
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0014 0.0133 0.0127
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0253 0.6096 0.6096
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0017 0.0218 0.0506
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0026 0.0433 0.0433
Schistosoma mansoni syntenin 0.001 0.0052 0.0052
Loa Loa (eye worm) PX domain-containing protein 0.001 0.0052 0.0052
Brugia malayi Syntrophin-1 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0026 0.0433 0.0433
Echinococcus multilocularis nervana 2 0.0026 0.0433 0.0433
Toxoplasma gondii P-type ATPase PMA1 0.0011 0.0064 0.0131
Schistosoma mansoni sap-97 0.001 0.0052 0.0052
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.041 1 1
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Echinococcus multilocularis Partitioning defective 3 protein B 0.001 0.0052 0.0052
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.001 0.0052 0.0052
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.001 0.0052 0.0052
Schistosoma mansoni cytochrome B5 0.0047 0.0954 0.0954
Brugia malayi Guanylate kinase family protein 0.001 0.0052 0.0052
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0157 0.3698 0.3612
Schistosoma mansoni sodium/chloride dependent transporter 0.0318 0.7729 0.7729
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.001 0.0052 0.0052
Mycobacterium ulcerans oxidoreductase 0.0047 0.0954 0.0954
Plasmodium falciparum amino acid transporter, putative 0.0054 0.1141 0.1021
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0009 0.0006 0.0006
Brugia malayi protein kinase C-binding protein PICK1 0.001 0.0052 0.0052
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.001 0.0052 0.0052
Echinococcus granulosus Na:H exchange regulatory cofactor NHE RF2 0.001 0.0052 0.0052
Giardia lamblia Nitric oxide synthase, inducible 0.0363 0.884 1
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0017 0.0218 0.0218
Echinococcus multilocularis PRKCA binding protein 0.001 0.0052 0.0052
Mycobacterium tuberculosis Possible oxygenase 0.0047 0.0954 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0026 0.0433 0.0433
Echinococcus granulosus cell polarity protein 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Plasmodium falciparum ferredoxin--NADP reductase 0.0047 0.0954 0.0832
Leishmania major oxidoreductase-like protein 0.0047 0.0954 0.0954
Schistosoma mansoni PDZ domain protein 0.001 0.0052 0.0052
Leishmania major calcium motive p-type ATPase, putative 0.0014 0.0133 0.0133
Trichomonas vaginalis cation-transporting ATPase, putative 0.0017 0.0218 0.0212
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0026 0.0433 0.0433
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0006 0.0006
Loa Loa (eye worm) guanylate kinase 0.001 0.0052 0.0052
Brugia malayi hypothetical protein 0.001 0.0052 0.0052
Toxoplasma gondii hypothetical protein 0.0054 0.1141 0.2348
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.041 1 1
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0054 0.1141 0.1141
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.0047 0.0954 0.0752
Echinococcus granulosus disks large 3 0.001 0.0052 0.0052
Echinococcus granulosus 55 kDa erythrocyte membrane protein 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0054 0.1141 0.1141
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0054 0.1141 0.1141
Schistosoma mansoni syntrophin 0.001 0.0052 0.0052
Echinococcus multilocularis nervana 2 0.0026 0.0433 0.0433
Schistosoma mansoni dishevelled 0.001 0.0052 0.0052
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0105 0.0105
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.001 0.0052 0.0052
Leishmania major NADH-dependent fumarate reductase-like protein 0.0047 0.0954 0.0954
Loa Loa (eye worm) hypothetical protein 0.0054 0.1141 0.1141
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0054 0.1141 0.1141
Schistosoma mansoni NADPH flavin oxidoreductase 0.0206 0.4936 0.4936
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Echinococcus multilocularis disks large 1 0.001 0.0052 0.0052
Echinococcus multilocularis Na(+):H(+) exchange regulatory cofactor NHE RF2 0.001 0.0052 0.0052
Plasmodium falciparum transporter, putative 0.0054 0.1141 0.1021
Schistosoma mansoni Patj homolog 0.001 0.0052 0.0052
Echinococcus granulosus Rho GTPase activating protein 21 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0157 0.3698 0.3698
Schistosoma mansoni hypothetical protein 0.001 0.0052 0.0052
Leishmania major NADH-dependent fumarate reductase, putative 0.0047 0.0954 0.0954
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0054 0.1141 0.1141
Echinococcus multilocularis amyloid beta A4 protein 0.001 0.0052 0.0052
Brugia malayi PDZ domain containing protein 0.001 0.0052 0.0052
Echinococcus granulosus pdz domain containing protein 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0054 0.1141 0.1141
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0017 0.0218 0.0506
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0014 0.0133 0.0133
Schistosoma mansoni hypothetical protein 0.001 0.0052 0.0052
Schistosoma mansoni protein kinase C alpha binding protein 0.001 0.0052 0.0052
Echinococcus multilocularis sodium and chloride dependent glycine 0.0054 0.1141 0.1141
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0054 0.1141 0.1141
Trypanosoma cruzi nitrate reductase, putative 0.0047 0.0954 0.0954
Echinococcus granulosus cytochrome b5 reductase 4 0.0047 0.0954 0.0954
Echinococcus granulosus ligand of numb protein x 2 0.001 0.0052 0.0052
Echinococcus granulosus glutamate receptor interacting protein 1 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0047 0.0954 0.0954
Onchocerca volvulus 0.0054 0.1141 0.1418
Brugia malayi PDZ domain containing protein 0.001 0.0052 0.0052
Leishmania major P-type H -ATPase, putative 0.0011 0.0064 0.0064
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0009 0.0006 0.0006
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0047 0.0954 0.0954
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Loa Loa (eye worm) syntrophin-1 0.001 0.0052 0.0052
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.001 0.0052 0.0052
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.0047 0.0954 0.1492
Echinococcus granulosus amyloid beta A4 protein 0.001 0.0052 0.0052
Echinococcus multilocularis multiple pdz domain protein 0.001 0.0052 0.0052
Echinococcus granulosus peripheral plasma membrane protein CASK 0.001 0.0052 0.0052
Brugia malayi DIX domain containing protein 0.001 0.0052 0.0052
Echinococcus granulosus C2 calcium dependent membrane targeting 0.001 0.0052 0.0052
Echinococcus multilocularis PDZ domain containing protein GIPC3 0.001 0.0052 0.0052
Brugia malayi Na,K-ATPase alpha subunit 0.0017 0.0218 0.0218
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0009 0.0006 0.0006
Echinococcus granulosus calcium transporting atpase 0.0014 0.0133 0.0133
Schistosoma mansoni multiple pdz domain protein 0.001 0.0052 0.0052
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.0047 0.0954 0.1963
Schistosoma mansoni maguk P55 subfamily member 35 0.001 0.0052 0.0052
Echinococcus multilocularis pdz domain containing protein 0.001 0.0052 0.0052
Echinococcus granulosus pdz domain containing protein 0.001 0.0052 0.0052
Brugia malayi FAD binding domain containing protein 0.0253 0.6096 0.6096
Echinococcus granulosus multiple pdz domain protein 0.001 0.0052 0.0052
Echinococcus granulosus nervana 2 0.0026 0.0433 0.0433
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0105 0.0105
Schistosoma mansoni pdz domain containing protein 0.001 0.0052 0.0052
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.001 0.0052 0.0052
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0014 0.0133 0.0133
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0054 0.1141 0.1141
Brugia malayi hypothetical protein 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0318 0.7729 0.7729
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Trypanosoma brucei calcium-translocating P-type ATPase 0.0014 0.0133 0.0133
Echinococcus granulosus Microtubule-associated serine/threonine-protein kinase 0.001 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.001 0.0052 0.0052
Toxoplasma gondii P-type ATPase4, putative 0.0017 0.0218 0.0449
Schistosoma mansoni ATPase 0.0017 0.0218 0.0218
Schistosoma mansoni dishevelled 0.001 0.0052 0.0052
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0047 0.0954 0.0954
Brugia malayi Ferm domain 0.001 0.0052 0.0052
Echinococcus multilocularis 55 kDa erythrocyte membrane protein 0.001 0.0052 0.0052
Echinococcus granulosus disks large 1 0.001 0.0052 0.0052
Schistosoma mansoni discs large 0.001 0.0052 0.0052
Brugia malayi hypothetical protein 0.001 0.0052 0.0052
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0218 0.0212
Entamoeba histolytica type A flavoprotein, putative 0.0157 0.3698 1
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0157 0.3698 0.3694
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.001 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0047 0.0954 0.0954
Brugia malayi hypothetical protein 0.001 0.0052 0.0052
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0017 0.0218 0.0218
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.001 0.0052 0.0052
Schistosoma mansoni leucine-rich repeat protein 0.001 0.0052 0.0052
Brugia malayi Hypothetical 13.5 kDa protein C45G9.7 in chromosome III 0.001 0.0052 0.0052
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0157 0.3698 0.3694
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0014 0.0133 0.0133
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0026 0.0433 0.0433
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0012 0.0082 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.0054 0.1141 0.1141
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0043 0.087 0.087
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0047 0.0954 0.0954
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0014 0.0133 0.0133
Echinococcus multilocularis syndecan binding protein (syntenin) 0.001 0.0052 0.0052
Echinococcus granulosus PRKCA binding protein 0.001 0.0052 0.0052
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0047 0.0954 0.0954
Leishmania major cytochrome-b5 reductase, putative 0.0047 0.0954 0.0954
Echinococcus granulosus pdz domain containing protein 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0054 0.1141 0.1141
Schistosoma mansoni pdz domain containing protein 0.001 0.0052 0.0052
Trypanosoma cruzi cytochrome P450 reductase, putative 0.041 1 1
Loa Loa (eye worm) PDZ-domain-containing protein scribble 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0054 0.1141 0.1141
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0014 0.0133 0.0275
Echinococcus granulosus nervana 2 0.0026 0.0433 0.0433
Echinococcus granulosus multiple pdz domain protein 0.001 0.0052 0.0052
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0017 0.0218 0.0218
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0047 0.0954 0.0954
Trypanosoma cruzi p450 reductase, putative 0.041 1 1
Echinococcus granulosus partitioning defective 3 0.001 0.0052 0.0052
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0054 0.1141 0.1141
Schistosoma mansoni multiple pdz domain protein 0.001 0.0052 0.0052
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0318 0.7729 0.7729
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Schistosoma mansoni regulator of G protein signaling 0.001 0.0052 0.0052
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0318 0.7729 0.7729
Echinococcus granulosus protein lin 7 B 0.001 0.0052 0.0052
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.041 1 1
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0054 0.1141 0.1141
Loa Loa (eye worm) cell junction protein LIN-7 0.001 0.0052 0.0052
Echinococcus multilocularis membrane associated guanylate kinase ww and pdz 0.001 0.0052 0.0052
Echinococcus granulosus rho guanine nucleotide exchange factor 12 0.001 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.001 0.0052 0.0052
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.001 0.0052 0.0052
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0052 0.0052
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0014 0.0133 0.0133
Echinococcus multilocularis partitioning defective protein 6 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Brugia malayi RasGEF domain containing protein 0.001 0.0052 0.0052
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0047 0.0954 1
Echinococcus multilocularis beta 1 syntrophin 0.001 0.0052 0.0052
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.001 0.0052 0.0052
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.041 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Schistosoma mansoni lin-7-like proteins 0.001 0.0052 0.0052
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0047 0.0954 0.0954
Echinococcus granulosus Partitioning defective 3 protein B 0.001 0.0052 0.0052
Echinococcus multilocularis pdz domain containing protein 0.001 0.0052 0.0052
Schistosoma mansoni afadin (af-6 protein) 0.001 0.0052 0.0052
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0014 0.0133 0.0133
Toxoplasma gondii flavodoxin domain-containing protein 0.0203 0.4858 1
Echinococcus multilocularis MAGUK p55 subfamily 0.001 0.0052 0.0052
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0054 0.1141 0.1141
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0047 0.0954 0.0954
Entamoeba histolytica type A flavoprotein, putative 0.0157 0.3698 1
Leishmania major p450 reductase, putative 0.041 1 1
Schistosoma mansoni multiple pdz domain protein 0.001 0.0052 0.0052
Trypanosoma brucei oxidoreductase-protein, putative 0.0047 0.0954 0.0954
Brugia malayi hypothetical protein 0.0054 0.1141 0.1141
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.041 1 1
Echinococcus granulosus myeloid:lymphoid or mixed lineage leukemia 0.001 0.0052 0.0052
Onchocerca volvulus 0.0054 0.1141 0.1418
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0105 0.0105
Echinococcus multilocularis MAGUK p55 subfamily 0.001 0.0052 0.0052
Loa Loa (eye worm) FAD binding domain-containing protein 0.0253 0.6096 0.6096
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.001 0.0052 0.0052
Leishmania major cytochrome-b5 reductase, putative 0.0047 0.0954 0.0954
Echinococcus multilocularis MAGUK p55 subfamily 0.001 0.0052 0.0052
Leishmania major reductase, putative 0.0047 0.0954 0.0954
Loa Loa (eye worm) PDZ domain-containing protein 0.001 0.0052 0.0052
Echinococcus multilocularis nervana 2 0.0026 0.0433 0.0433
Echinococcus multilocularis ligand of numb protein x 2 0.001 0.0052 0.0052
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.001 0.0052 0.0052
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.041 1 1
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0017 0.0218 0.0218
Schistosoma mansoni lim domain 0.001 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.001 0.0052 0.0052
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0014 0.0133 0.0133
Echinococcus granulosus methionine synthase reductase 0.0253 0.6096 0.6096
Giardia lamblia Flavohemoprotein lateral transfer candidate 0.0047 0.0954 0.0942
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0157 0.3698 0.3698
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Schistosoma mansoni sodium/chloride dependent transporter 0.0054 0.1141 0.1141
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0017 0.0218 0.0218
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0054 0.1141 0.1141
Brugia malayi gopc protein 0.001 0.0052 0.0052
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.087 0.087
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0363 0.884 0.8839
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0105 0.0105
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0017 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Echinococcus granulosus partitioning defective 3 0.001 0.0052 0.0052
Loa Loa (eye worm) norepinephrine transporter 0.0318 0.7729 0.7729
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Echinococcus multilocularis tight junction protein ZO 3 0.001 0.0052 0.0052
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0012 0.0082 0.0082
Echinococcus multilocularis pdz domain containing protein 0.001 0.0052 0.0052
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0054 0.1141 0.1801
Trypanosoma cruzi reductase, putative 0.0047 0.0954 0.0954
Trypanosoma cruzi P-type H+-ATPase, putative 0.0011 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.001 0.0052 0.0052
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0047 0.0954 0.0954
Schistosoma mansoni ATP-dependent RNA Helicase 0.001 0.0052 0.0052
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0969 0.0969
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0006 0.0006
Echinococcus multilocularis sodium and chloride dependent glycine 0.0054 0.1141 0.1141
Loa Loa (eye worm) PAR-6 protein 0.001 0.0052 0.0052
Loa Loa (eye worm) 9ORF binding protein 1 0.001 0.0052 0.0052
Brugia malayi PDZ domain 0.001 0.0052 0.0052
Leishmania major NADH-cytochrome b5 reductase, putative 0.0047 0.0954 0.0954
Trichomonas vaginalis cation-transporting ATPase, putative 0.0011 0.0064 0.0057
Loa Loa (eye worm) E1-E2 ATPase 0.0011 0.0064 0.0064
Schistosoma mansoni leucine-rich repeat protein 0.001 0.0052 0.0052
Toxoplasma gondii flavodoxin domain-containing protein 0.0203 0.4858 1
Leishmania major hypothetical protein, conserved 0.0157 0.3698 0.3698
Echinococcus granulosus nervana 2 0.0026 0.0433 0.0433
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0017 0.0218 0.0218
Brugia malayi diaphorase 0.0047 0.0954 0.0954
Brugia malayi FAD binding domain containing protein 0.041 1 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.001 0.0052 0.0052
Echinococcus granulosus NADPH cytochrome P450 reductase 0.041 1 1
Schistosoma mansoni sh3 and multiple ankyrin repeat domains protein 12 (shank12) 0.001 0.0052 0.0052
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0799 0.0793
Brugia malayi Peripheral plasma membrane protein CASK 0.001 0.0052 0.0052
Echinococcus granulosus multiple pdz domain protein 0.001 0.0052 0.0052
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.001 0.0052 0.0052
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0047 0.0954 0.0954
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0017 0.0218 0.0506
Schistosoma mansoni hypothetical protein 0.001 0.0052 0.0052
Echinococcus granulosus MAGUK p55 subfamily 0.001 0.0052 0.0052
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0017 0.0218 0.0218
Schistosoma mansoni cell polarity protein 0.001 0.0052 0.0052
Echinococcus multilocularis cell polarity protein leucine rich repeat 0.001 0.0052 0.0052
Schistosoma mansoni sodium/chloride dependent transporter 0.0054 0.1141 0.1141
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0012 0.0082 0.0082
Schistosoma mansoni ATPase 0.0017 0.0218 0.0218
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0157 0.3698 0.3694
Toxoplasma gondii hypothetical protein 0.0054 0.1141 0.2348
Plasmodium falciparum nitric oxide synthase, putative 0.041 1 1
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0026 0.0433 0.0433
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0052 0.0052
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0054 0.1141 0.1141
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0054 0.1141 0.1141
Schistosoma mansoni tight junction protein 0.001 0.0052 0.0052
Echinococcus multilocularis partitioning defective 3 0.001 0.0052 0.0052
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0017 0.0218 0.0218
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0047 0.0954 0.0954
Echinococcus granulosus Na:K ATPase alpha subunit 0.0014 0.0133 0.0133
Echinococcus multilocularis Rho GTPase activating protein 21 0.001 0.0052 0.0052
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.001 0.0052 0.0052
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0047 0.0954 0.0954
Brugia malayi syntenin 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.001 0.0052 0.0052
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0047 0.0954 0.0954
Leishmania major calcium-translocating P-type ATPase 0.0017 0.0218 0.0218
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0054 0.1141 0.1141
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0006 0.0006
Echinococcus multilocularis multiple pdz domain protein 0.001 0.0052 0.0052
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0009 0.0006 0.0006
Leishmania major cytochrome P450 reductase, putative 0.0363 0.884 0.884
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0006 0.0006
Echinococcus multilocularis cytochrome b5 reductase 4 0.0047 0.0954 0.0954
Loa Loa (eye worm) calcium ATPase 0.001 0.0033 0.0033
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.001 0.0052 0.0052
Brugia malayi Cyclic-nucleotide gated cation channel 0.0009 0.0006 0.0006
Loa Loa (eye worm) serotonin transporter b 0.0318 0.7729 0.7729
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0047 0.0954 0.0954
Entamoeba histolytica type A flavoprotein, putative 0.0157 0.3698 1
Brugia malayi Synapse defective protein 1 0.001 0.0052 0.0052
Echinococcus granulosus syndecan binding protein syntenin 0.001 0.0052 0.0052
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.041 1 1
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0052 0.0052
Schistosoma mansoni multiple pdz domain protein 0.001 0.0052 0.0052
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0014 0.0133 0.0133
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0006 0.0006
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0014 0.0133 0.0133
Schistosoma mansoni cell polarity protein 0.001 0.0052 0.0052
Trypanosoma brucei P-type H+-ATPase, putative 0.0011 0.0064 0.0064
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0014 0.0133 0.0133
Echinococcus multilocularis membrane associated guanylate kinase, WW and PDZ 0.001 0.0052 0.0052
Trypanosoma cruzi oxidoreductase-protein, putative 0.0047 0.0954 0.0954
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0017 0.0218 0.0449
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.001 0.0052 0.0052
Brugia malayi Neurabin protein 1 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0017 0.0218 0.0218
Echinococcus multilocularis neurabin 1 0.001 0.0052 0.0052
Brugia malayi Membrane calcium atpase protein 3 0.0014 0.0133 0.0133
Plasmodium vivax hypothetical protein, conserved 0.0157 0.3698 0.3557
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0017 0.0218 0.0218
Plasmodium vivax flavodoxin domain containing protein 0.0363 0.884 0.8814
Mycobacterium ulcerans oxygenase 0.0047 0.0954 0.0954
Trypanosoma brucei NADH-dependent fumarate reductase 0.0047 0.0954 0.0954
Brugia malayi PDZ-domain protein scribble 0.001 0.0052 0.0052
Brugia malayi interleukin-16 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0006
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0012 0.0082 0.0082
Schistosoma mansoni diflavin oxidoreductase 0.0203 0.4858 0.4858
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0054 0.1141 0.1141
Brugia malayi Guanylate kinase family protein 0.001 0.0052 0.0052
Brugia malayi E1-E2 ATPase family protein 0.0011 0.0064 0.0064
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0017 0.0218 0.0218
Schistosoma mansoni amyloid beta A4 protein related 0.001 0.0052 0.0052
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.0047 0.0954 0.0954
Loa Loa (eye worm) diaphorase 0.0047 0.0954 0.0954
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0006 0.0006
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.041 1 1
Echinococcus multilocularis serotonin transporter 0.0318 0.7729 0.7729
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0006 0.0006
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0017 0.0218 0.0218
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.001 0.0052 0.0052
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0009 0.0006 0.0006
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0157 0.3698 0.3612
Loa Loa (eye worm) hypothetical protein 0.0054 0.1141 0.1141
Loa Loa (eye worm) AGC/MAST/MAST protein kinase 0.001 0.0052 0.0052
Treponema pallidum flavodoxin 0.0157 0.3698 0.405
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.001 0.0052 0.0052
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0026 0.0433 0.0433
Brugia malayi 9ORF binding protein 1 0.001 0.0052 0.0052
Echinococcus multilocularis glutamate receptor interacting protein 1 0.001 0.0052 0.0052
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0026 0.0433 0.0433
Loa Loa (eye worm) flavodoxin family protein 0.0157 0.3698 0.3698
Trypanosoma cruzi p450 reductase, putative 0.0047 0.0954 0.0954
Loa Loa (eye worm) FAD binding domain-containing protein 0.041 1 1
Loa Loa (eye worm) hypothetical protein 0.0318 0.7729 0.7729
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0047 0.0954 0.0954
Entamoeba histolytica type A flavoprotein, putative 0.0157 0.3698 1
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0017 0.0218 0.0086
Echinococcus multilocularis methionine synthase reductase 0.0253 0.6096 0.6096
Plasmodium vivax amine transporter, putative 0.0054 0.1141 0.0943
Loa Loa (eye worm) hypothetical protein 0.0037 0.0728 0.0728
Mycobacterium ulcerans electron transfer protein FdxB 0.0047 0.0954 0.0954
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0218 0.0212
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0017 0.0218 0.0218
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0054 0.1141 0.2348
Echinococcus multilocularis myeloid:lymphoid or mixed lineage leukemia 0.001 0.0052 0.0052
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0052 0.0052
Brugia malayi Patj homolog 0.001 0.0052 0.0052
Echinococcus granulosus pdz domain containing protein 0.001 0.0052 0.0052
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0047 0.0954 0.0954
Schistosoma mansoni multiple pdz domain protein 0.001 0.0052 0.0052
Onchocerca volvulus 0.0047 0.0954 0.1175
Trypanosoma cruzi cytochrome P450 reductase, putative 0.041 1 1
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0047 0.0954 1
Schistosoma mansoni cell polarity protein 0.001 0.0052 0.0052
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0047 0.0954 0.0954
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.001 0.0052 0.0052
Schistosoma mansoni cell polarity protein 0.001 0.0052 0.0052
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0017 0.0218 0.0218
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0054 0.1141 0.1141
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0218 0.0212
Schistosoma mansoni MAGUK homolog 0.001 0.0052 0.0052
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0013 0.0105 0.0105
Echinococcus multilocularis disks large 3 0.001 0.0052 0.0052
Brugia malayi gamma-syntrophin-like protein SYN2 0.001 0.0052 0.0052
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.0047 0.0954 0.1963
Brugia malayi rho guanine nucleotide exchange factor 12 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Plasmodium vivax ferredoxin--NADP reductase, putative 0.0047 0.0954 0.0752
Schistosoma mansoni hypothetical protein 0.001 0.0052 0.0052
Leishmania major NADH-cytochrome b5 reductase, putative 0.0047 0.0954 0.0954
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0054 0.1141 0.1141
Loa Loa (eye worm) solute carrier family 6 member 4 0.0318 0.7729 0.7729
Echinococcus granulosus neurabin 1 0.001 0.0052 0.0052
Mycobacterium ulcerans monooxygenase 0.0047 0.0954 0.0954
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.001 0.0052 0.0052
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0157 0.3698 0.3694
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0047 0.0954 0.0954
Onchocerca volvulus 0.0026 0.0433 0.0496
Schistosoma mansoni hypothetical protein 0.001 0.0052 0.0052
Brugia malayi hypothetical protein 0.001 0.0052 0.0052
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0014 0.0133 0.0133
Leishmania major P-type H -ATPase, putative 0.0011 0.0064 0.0064
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0017 0.0218 0.0097
Schistosoma mansoni hypothetical protein 0.001 0.0052 0.0052
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0017 0.0218 0.0218
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0006 0.0006
Echinococcus granulosus sodium and chloride dependent glycine 0.0054 0.1141 0.1141
Echinococcus multilocularis rho guanine nucleotide exchange factor 12 0.001 0.0052 0.0052
Echinococcus granulosus tight junction protein ZO 3 0.001 0.0052 0.0052
Brugia malayi PDZ domain containing protein 0.001 0.0052 0.0052
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.041 1 1
Loa Loa (eye worm) guanylate kinase 0.001 0.0052 0.0052
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0014 0.0133 0.0133
Onchocerca volvulus 0.0318 0.7729 1
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0017 0.0218 0.0218
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0026 0.0433 0.0433
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0047 0.0954 0.0954
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0047 0.0954 0.0954
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0054 0.1141 0.1141
Echinococcus multilocularis calcium transporting atpase 0.0014 0.0133 0.0133
Echinococcus multilocularis 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0054 0.1141 0.1141
Schistosoma mansoni transmemberane protein 0.0026 0.0433 0.0433
Loa Loa (eye worm) hypothetical protein 0.0282 0.682 0.682
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0052 0.0052
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0006 0.0006
Echinococcus multilocularis protein piccolo 0.001 0.0052 0.0052
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0017 0.0218 0.0218
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0047 0.0954 0.0954
Echinococcus multilocularis pdz domain containing protein 0.001 0.0052 0.0052
Mycobacterium tuberculosis Probable oxidoreductase 0.0047 0.0954 1
Brugia malayi cell junction protein LIN-7 0.001 0.0052 0.0052
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0054 0.1141 0.1141
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0017 0.0218 0.0449
Echinococcus granulosus beta 1 syntrophin 0.001 0.0052 0.0052
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0014 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0433 0.0433
Leishmania major NADH-cytochrome b5 reductase, putative 0.0047 0.0954 0.0954
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0012 0.0082 0.0859
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0218 0.0212
Echinococcus multilocularis glutamate receptor interacting protein 1 0.001 0.0052 0.0052
Onchocerca volvulus 0.0054 0.1141 0.1418
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0799 0.0793
Echinococcus granulosus cytochrome b5 reductase 4 0.0047 0.0954 0.0954
Trichomonas vaginalis sulfite reductase, putative 0.041 1 1
Brugia malayi Protein-tyrosine phosphatase 1 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0017 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0047 0.0954 0.0954
Loa Loa (eye worm) hypothetical protein 0.0013 0.0105 0.0105
Schistosoma mansoni hypothetical protein 0.001 0.0052 0.0052
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.0047 0.0954 0.0832
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0009 0.0006 0.0006
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0157 0.3698 0.3698
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0047 0.0954 0.0954
Leishmania major calcium-transporting ATPase, putative 0.0014 0.0133 0.0133
Loa Loa (eye worm) X11 protein 0.001 0.0052 0.0052
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0047 0.0954 0.0954
Brugia malayi Shank2E 0.001 0.0052 0.0052
Echinococcus granulosus nervana 2 0.0026 0.0433 0.0433
Trypanosoma brucei NADH-dependent fumarate reductase 0.0047 0.0954 0.0954
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0054 0.1141 0.2348
Onchocerca volvulus 0.0017 0.0218 0.0216
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Schistosoma mansoni MAGUK homolog 0.001 0.0052 0.0052
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0047 0.0954 0.0954
Echinococcus granulosus MAGUK p55 subfamily 0.001 0.0052 0.0052
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.041 1 1
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0026 0.0433 0.0433
Giardia lamblia Hypothetical protein 0.0363 0.884 1
Echinococcus granulosus 3'partial|membrane associated guanylate kinase ww and pdz 0.001 0.0052 0.0052
Trypanosoma brucei P-type H+-ATPase, putative 0.0011 0.0064 0.0064
Brugia malayi hypothetical protein 0.001 0.0052 0.0052
Leishmania major P-type ATPase, putative 0.0014 0.0133 0.0133
Echinococcus multilocularis protein lin 7 B 0.001 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Schistosoma mansoni cytochrome P450 reductase 0.041 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0006 0.0006
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.001 0.0052 0.0052
Brugia malayi PDZ domain containing protein 0.001 0.0052 0.0052
Echinococcus multilocularis microtubule associated serine:threonine protein 0.001 0.0052 0.0052
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0014 0.0133 0.0133
Trypanosoma cruzi P-type H+-ATPase, putative 0.0011 0.0064 0.0064

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 13.4 uM kg-1 Inhibition of pentagastrin-stimulated gastric acid secretion in the anesthetized rat after iv administration ChEMBL. 7629813
ED50 (functional) = 13.4 uM kg-1 Inhibition of pentagastrin-stimulated gastric acid secretion in the anesthetized rat after iv administration ChEMBL. 7629813
IC50 (binding) = 0.58 uM Inhibition of K+ -stimulated gastric ATPase activity was measured using lyophilized gastric vesicles at pH 7 ChEMBL. 7629813
IC50 (binding) = 0.58 uM Inhibition of K+ -stimulated gastric ATPase activity was measured using lyophilized gastric vesicles at pH 7 ChEMBL. 7629813

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.