Detailed information for compound 157285

Basic information

Technical information
  • TDR Targets ID: 157285
  • Name: [2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl (Z )-octadec-9-enoate
  • MW: 410.587 | Formula: C24H42O5
  • H donors: 1 H acceptors: 3 LogP: 6.75 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCC/C=C\CCCCCCCC(=O)OCC1(CO)CCC(=O)O1
  • InChi: 1S/C24H42O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)28-21-24(20-25)19-18-23(27)29-24/h9-10,25H,2-8,11-21H2,1H3/b10-9-
  • InChiKey: PEAIWKSTMMPPID-KTKRTIGZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-(hydroxymethyl)-5-oxo-tetrahydrofuran-2-yl]methyl (Z)-octadec-9-enoate
  • (Z)-9-octadecenoic acid [2-(hydroxymethyl)-5-oxo-2-tetrahydrofuranyl]methyl ester
  • [2-(hydroxymethyl)-5-oxo-oxolan-2-yl]methyl (Z)-octadec-9-enoate
  • (Z)-octadec-9-enoic acid (5-keto-2-methylol-tetrahydrofuran-2-yl)methyl ester
  • (Z)-octadec-9-enoic acid [2-(hydroxymethyl)-5-oxo-2-tetrahydrofuranyl]methyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein kinase C, alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Brugia malayi Protein kinase c protein 2 Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus Protein kinase C brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis telomerase reverse transcriptase subunit Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C gamma type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus protein kinase C gamma type Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis serine threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Calcium-dependent protein kinase C, putative Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis Protein kinase C, brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0011 0.0047 0.0252
Plasmodium vivax vivapain-2 0.0009 0.0026 0.0013
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0009 0.0033 0.0054
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0148 0.0148
Schistosoma mansoni hypothetical protein 0.0027 0.024 0.0233
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0148 0.081
Loa Loa (eye worm) hypothetical protein 0.0019 0.0148 0.0799
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0026 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0321 0.6876
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0148 0.0799
Echinococcus multilocularis cathepsin L cysteine protease 0.0009 0.0026 0.0026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0321 0.6876
Onchocerca volvulus Neurogenic locus notch homolog 0.0027 0.024 0.1123
Schistosoma mansoni intermediate filament proteins 0.0021 0.0176 0.0169
Brugia malayi Calcium binding EGF domain containing protein 0.0027 0.024 0.1344
Echinococcus multilocularis thioredoxin glutathione reductase 0.0025 0.0217 0.0217
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0009 0.0033 0.0054
Brugia malayi PAS domain containing protein 0.0026 0.0225 0.1254
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0164 0.0816
Loa Loa (eye worm) AGC/NDR protein kinase 0.0011 0.0047 0.0252
Echinococcus multilocularis Polycystic kidney disease protein 0.0153 0.1737 0.1737
Brugia malayi Cathepsin L-like precursor 0.0009 0.0026 0.0106
Plasmodium falciparum glutathione reductase 0.0025 0.0217 0.1131
Echinococcus multilocularis cathepsin L cysteine protease 0.0009 0.0026 0.0026
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0041 0.0412 0.2263
Schistosoma mansoni slit 0.0027 0.024 0.0233
Onchocerca volvulus 0.0019 0.0143 0.067
Plasmodium falciparum perforin-like protein 2 0.0063 0.0675 0.3802
Plasmodium vivax perforin-like protein 4 0.0063 0.0675 0.3802
Schistosoma mansoni hypothetical protein 0.0027 0.024 0.0233
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0221
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0118 0.1327 0.132
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0148 0.081
Treponema pallidum fructose-bisphosphate aldolase 0.0308 0.3577 1
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0019 0.0143 0.0143
Leishmania major cathepsin L-like protease 0.0034 0.0321 0.7039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0009 0.0026 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0047 0.013
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0009 0.0024 0.0016
Schistosoma mansoni aldehyde dehydrogenase 0.0032 0.03 0.0292
Loa Loa (eye worm) hypothetical protein 0.0009 0.0028 0.0152
Echinococcus granulosus enteropeptidase 0.0019 0.0143 0.0143
Brugia malayi Cytochrome P450 family protein 0.0019 0.0146 0.0797
Echinococcus granulosus RNA directed DNA polymerase 0.0048 0.0487 0.0487
Brugia malayi N-terminal motif family protein 0.0095 0.1053 0.6043
Plasmodium vivax perforin-like protein 3 0.0063 0.0675 0.3802
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0146 0.0787
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0009 0.0033 0.0721
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0045 0.0456 0.2568
Brugia malayi hypothetical protein 0.0009 0.0028 0.0117
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0143 0.0136
Toxoplasma gondii calcium binding egf domain-containing protein 0.0031 0.0293 0.4272
Brugia malayi GCC2 and GCC3 family protein 0.0027 0.024 0.1344
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0048 0.0487 0.0487
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3577 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0009 0.0026 0.0026
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0011 0.0054 0.0694
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0024 0.0522
Echinococcus granulosus microtubule associated protein 2 0.0364 0.4247 0.4247
Trypanosoma cruzi importin beta-1 subunit, putative 0.0012 0.0068 0.1484
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0164 0.3588
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0164 0.0901
Loa Loa (eye worm) cytochrome P450 0.0009 0.0033 0.0178
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0151 0.0144
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0047 0.013
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0214
Brugia malayi RNA, U transporter 1 0.0043 0.0435 0.2471
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0042
Echinococcus granulosus lipoxygenase domain containing protein 0.0153 0.1737 0.1737
Entamoeba histolytica protein kinase, putative 0.0011 0.0047 0.0109
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0009 0.0033 0.0054
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0016 0.0107 0.0107
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0146 0.0725
Echinococcus granulosus myotubularin protein 13 0.0007 0.0008 0.0008
Mycobacterium ulcerans aldehyde dehydrogenase 0.0032 0.03 0.1641
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0009 0.0033 0.0054
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0221
Entamoeba histolytica protein kinase, putative 0.0011 0.0047 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0717 0.071
Echinococcus multilocularis fat cadherin tumor suppressor 0.0027 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Schistosoma mansoni zinc finger protein 0.0009 0.0028 0.002
Echinococcus multilocularis lipoxygenase domain containing protein 0.0153 0.1737 0.1737
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0027 0.024 0.0233
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0164 0.0816
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0009 0.0026 0.0073
Echinococcus granulosus protein jagged 1 0.0027 0.024 0.024
Onchocerca volvulus 0.0019 0.0143 0.067
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0028 0.002
Plasmodium vivax importin-beta 2, putative 0.0015 0.0102 0.0455
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0063 0.0673 0.3855
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3577 1
Trypanosoma cruzi cruzipain precursor, putative 0.0034 0.0321 0.7039
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.0016 0.0113 0.0661
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0028 0.0131
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0045 0.0456 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0308 0.3577 1
Echinococcus multilocularis Tolloid protein 1 0.0031 0.0293 0.0293
Mycobacterium ulcerans DNA polymerase I 0.0016 0.0113 0.0528
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0008 0.0019 0.0012
Echinococcus multilocularis protein jagged 1 0.0027 0.024 0.024
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0013 0.0006
Brugia malayi Cathepsin L-like precursor 0.0009 0.0026 0.0106
Schistosoma mansoni importin beta-1 0.0015 0.0102 0.0094
Plasmodium falciparum thioredoxin reductase 0.0025 0.0217 0.1131
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0042
Loa Loa (eye worm) hypothetical protein 0.0031 0.0293 0.1583
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0164 0.0393
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0243 0.0236
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3577 1
Schistosoma mansoni cell polarity protein 0.0027 0.024 0.0233
Plasmodium vivax perforin-like protein 1 0.0063 0.0675 0.3802
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0009 0.0033 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0412 0.9025
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0148 0.014
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0009 0.0033 0.0721
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0011 0.0047 0.0252
Trypanosoma brucei rac serine-threonine kinase, putative 0.0011 0.0047 0.0528
Echinococcus granulosus N chimaerin 0.0008 0.0019 0.0019
Trypanosoma brucei importin beta-1 subunit, putative 0.0015 0.0102 0.1806
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0026 0.0073
Echinococcus multilocularis RUN 0.0153 0.1737 0.1737
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0321 0.6876
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0143 0.0136
Plasmodium vivax multidomain scavenger receptor, putative 0.0153 0.1737 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0028 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0148 0.081
Onchocerca volvulus 0.0009 0.0026 0.0122
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0011 0.0047 0.0047
Schistosoma mansoni unc-13 (munc13) 0.0009 0.0026 0.0018
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0042
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0009 0.0033 0.0054
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0143 0.0136
Echinococcus granulosus protein kinase c eta type 0.0007 0.0008 0.0008
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0047 0.0039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3577 1
Schistosoma mansoni notch 0.0027 0.024 0.0233
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Onchocerca volvulus 0.0009 0.0028 0.0131
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0148 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0026 0.0073
Echinococcus granulosus protein kinase C gamma type 0.006 0.063 0.063
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0009 0.0024 0.0522
Onchocerca volvulus 0.0027 0.024 0.1123
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0031 0.0293 0.0285
Schistosoma mansoni microtubule-associated protein tau 0.0364 0.4247 0.4242
Echinococcus multilocularis Mastin 0.0019 0.0143 0.0143
Toxoplasma gondii HEAT repeat-containing protein 0.0015 0.0102 0.1409
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0009 0.0026 0.0026
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0321 0.7039
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0148 0.014
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0018 0.013 0.285
Brugia malayi Muscle positioning protein 4 0.0027 0.024 0.1344
Loa Loa (eye worm) hypothetical protein 0.0009 0.0028 0.0152
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0016 0.0107 0.01
Schistosoma mansoni vav2 0.0008 0.0019 0.0012
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0164 0.0457
Schistosoma mansoni lipoxygenase 0.0849 1 1
Echinococcus multilocularis protein jagged 1 0.0027 0.024 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0026 0.0073
Onchocerca volvulus 0.0025 0.0222 0.1038
Echinococcus granulosus histone lysine methyltransferase setb 0.0016 0.0107 0.0107
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0011 0.0047 0.0047
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Echinococcus granulosus thioredoxin glutathione reductase 0.0025 0.0217 0.0217
Schistosoma mansoni hypothetical protein 0.0027 0.024 0.0233
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0027 0.0243 0.5332
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0028 0.002
Schistosoma mansoni nuclear receptor 0.0009 0.0028 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0028 0.0028
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0164 0.3588
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Plasmodium vivax SET domain protein, putative 0.0016 0.0107 0.0488
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0011 0.0057 0.1256
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0009 0.0028 0.0152
Loa Loa (eye worm) hypothetical protein 0.0015 0.0102 0.055
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0148 0.0148
Schistosoma mansoni rab6-interacting 0.0153 0.1737 0.173
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0148 0.081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0009 0.0026 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0148 0.081
Loa Loa (eye worm) hypothetical protein 0.0019 0.0148 0.0799
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0143 0.0136
Plasmodium vivax vivapain-2 0.0009 0.0026 0.0013
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0009 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.0012 0.0068 0.0168
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0047 0.013
Echinococcus granulosus macrophage expressed protein 0.0574 0.674 0.674
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0027 0.0243 0.5332
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0041 0.0041
Brugia malayi Kringle domain containing protein 0.0041 0.0412 0.2335
Loa Loa (eye worm) hypoxia-induced factor 1 0.0079 0.0861 0.465
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0164 0.0436
Echinococcus granulosus serine:threonine protein kinase N2 0.0011 0.0047 0.0047
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0057 0.0597 0.3407
Echinococcus granulosus delta-like protein 1 0.0027 0.024 0.024
Brugia malayi Fibulin-1 precursor 0.0031 0.0293 0.1649
Echinococcus granulosus neurogenic locus protein delta 0.0027 0.024 0.024
Trypanosoma brucei protein kinase, putative 0.0027 0.0243 0.5075
Trypanosoma brucei trypanothione reductase 0.0025 0.0217 0.4482
Leishmania major GTP-binding protein, putative 0.0011 0.0054 0.1187
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0143 0.0136
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.001 0.0044 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0717 0.071
Schistosoma mansoni lipoxygenase 0.0573 0.6732 0.6729
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0148 0.081
Mycobacterium leprae Conserved hypothetical protein 0.0009 0.0033 0.0193
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0045 0.0456 0.2592
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0009 0.0033 0.0054
Brugia malayi MAP kinase sur-1 0.0027 0.0243 0.1361
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0045 0.0456 0.2523
Brugia malayi protein kinase C3,putative 0.0008 0.0013 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0148 0.081
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0221
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0042
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0321 0.7039
Trichomonas vaginalis ran, putative 0.0011 0.0054 0.0151
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0271 0.1464
Brugia malayi Trypsin family protein 0.0019 0.0143 0.0784
Brugia malayi Cathepsin L-like precursor 0.0009 0.0026 0.0106
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0148 0.014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0321 0.6876
Onchocerca volvulus 0.0009 0.0026 0.0122
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0026 0.0051
Plasmodium vivax thioredoxin reductase, putative 0.0025 0.0217 0.1131
Echinococcus multilocularis raf serine:threonine protein kinase 0.0007 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0143 0.0775
Echinococcus granulosus fibropellin Ia 0.0027 0.024 0.024
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0009 0.0033 0.0054
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0008 0.0019 0.0019
Brugia malayi Cadherin domain containing protein 0.0027 0.024 0.1344
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0164 0.3234
Schistosoma mansoni notch 0.0027 0.024 0.0233
Leishmania major importin beta-1 subunit, putative 0.0012 0.0068 0.1484
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0016 0.0107 0.01
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0148 0.0148
Brugia malayi steroid hormone receptor 0.0019 0.0148 0.081
Brugia malayi hypothetical protein 0.0153 0.1737 1
Brugia malayi tailless protein 0.0009 0.0028 0.0117
Brugia malayi Protein kinase domain containing protein 0.0011 0.0047 0.0224
Echinococcus multilocularis survival motor neuron protein 1 0.0124 0.1397 0.1397
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0009 0.0026 0.0073
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0009 0.0026 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0321 0.6876
Echinococcus multilocularis laminin 0.0031 0.0293 0.0293
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0047 0.013
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0012 0.0068 0.0189
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0018 0.013 0.0363
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0146 0.3193
Schistosoma mansoni hypothetical protein 0.0025 0.0222 0.0214
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0024 0.0522
Echinococcus multilocularis neurogenic locus notch protein 0.0027 0.024 0.024
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0009 0.0033 0.0054
Trypanosoma cruzi trypanothione reductase, putative 0.0025 0.0217 0.477
Loa Loa (eye worm) hypothetical protein 0.0009 0.0028 0.0152
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0031 0.0293 0.1583
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0428 0.5004 0.5004
Brugia malayi Cadherin domain containing protein 0.0027 0.024 0.1344
Mycobacterium tuberculosis Probable reductase 0.0057 0.0597 0.3407
Echinococcus granulosus laminin 0.0031 0.0293 0.0293
Brugia malayi Trypsin family protein 0.0019 0.0143 0.0784
Onchocerca volvulus 0.0041 0.0412 0.1924
Leishmania major cathepsin L-like protease 0.0009 0.0026 0.0572
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0007 0.0006 0.0121
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0028 0.002
Brugia malayi nuclear receptor NHR-88 0.0009 0.0028 0.0117
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0042
Echinococcus granulosus survival motor neuron protein 1 0.0124 0.1397 0.1397
Schistosoma mansoni hypothetical protein 0.0027 0.024 0.0233
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0009 0.0033 0.0054
Brugia malayi conserved hypotetical protein 0.0009 0.0028 0.0117
Echinococcus granulosus transmembrane protease serine 3 0.0019 0.0143 0.0143
Brugia malayi nuclear hormone receptor 0.0019 0.0148 0.081
Echinococcus granulosus Rac GTPase activating protein 1 0.0007 0.0008 0.0008
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0047 0.013
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0007 0.0008 0.0042
Echinococcus multilocularis lipoxygenase domain containing protein 0.0153 0.1737 0.1737
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0016 0.0107 0.01
Echinococcus multilocularis lamin dm0 0.0021 0.0176 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0148 0.081
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0007 0.0008 0.0042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0009 0.0026 0.0073
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Schistosoma mansoni hypothetical protein 0.0019 0.0143 0.0136
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0148 0.014
Echinococcus granulosus RUN 0.0153 0.1737 0.1737
Loa Loa (eye worm) raf kinase 0.0007 0.0008 0.0042
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.002 0.0157 0.044
Schistosoma mansoni septate junction protein 0.0027 0.024 0.0233
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0007 0.0006 0.0121
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0008 0.0019 0.0105
Brugia malayi Cathepsin L-like precursor 0.0009 0.0026 0.0106
Brugia malayi bHLH-PAS transcription factor 0.0019 0.0146 0.0798
Brugia malayi hypothetical protein 0.0153 0.1737 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0148 0.081
Mycobacterium leprae putative cytochrome p450 0.0009 0.0033 0.0193
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0028 0.0028
Echinococcus granulosus cathepsin l cysteine peptidase 0.0009 0.0026 0.0026
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0009 0.0033 0.0721
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0011 0.0054 0.0085
Brugia malayi nuclear receptor RXR 0.001 0.0041 0.0191
Echinococcus granulosus slit 2 protein 0.0027 0.024 0.024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0321 0.6876
Brugia malayi Calcium binding EGF domain containing protein 0.0031 0.0293 0.1649
Brugia malayi hypothetical protein 0.001 0.0041 0.0191
Echinococcus granulosus importin subunit beta 1 0.0015 0.0102 0.0102
Echinococcus granulosus mitogen activated protein kinase 3 0.0027 0.0243 0.0243
Brugia malayi Doublecortin family protein 0.0153 0.1737 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0252
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0009 0.0033 0.0054
Schistosoma mansoni hypothetical protein 0.0014 0.0088 0.008
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0143 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0026 0.0073
Echinococcus multilocularis transfer RNA-Lys 0.0019 0.0146 0.0146
Schistosoma mansoni aryl hydrocarbon receptor 0.0026 0.0225 0.0217
Schistosoma mansoni unc-13 (munc13) 0.0009 0.0026 0.0018
Echinococcus granulosus protein kinase c iota type 0.0018 0.0133 0.0133
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.0157 0.0157
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0118 0.1327 0.1327
Plasmodium falciparum dihydroorotate dehydrogenase 0.0045 0.0456 0.2523
Wolbachia endosymbiont of Brugia malayi DNA polymerase I 0.0016 0.0113 0.2058
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0148 0.081
Chlamydia trachomatis hypothetical protein 0.0063 0.0675 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.1397 0.7547
Brugia malayi Trypsin-like protease protein 5 0.0019 0.0143 0.0784
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0026 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0047 0.013
Loa Loa (eye worm) nuclear receptor NHR-67 0.0009 0.0028 0.0152
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0143 0.0136
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Echinococcus granulosus protein kinase c epsilon type 0.0019 0.0151 0.0151
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0025 0.0222 0.1239
Loa Loa (eye worm) hypothetical protein 0.0031 0.0293 0.1583
Brugia malayi nuclear receptor RXR 0.0009 0.0028 0.0117
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0024 0.0522
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0146 0.0787
Loa Loa (eye worm) hypothetical protein 0.0019 0.0143 0.0775
Brugia malayi EGF-like domain containing protein 0.0027 0.024 0.1344
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0012 0.0068 0.0189
Trichomonas vaginalis CMGC family protein kinase 0.0027 0.0243 0.068
Echinococcus granulosus neurogenic locus notch protein 4 0.0027 0.024 0.024
Toxoplasma gondii exonuclease III APE 0.002 0.0164 0.2335
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0009 0.0033 0.0054
Schistosoma mansoni cytochrome P450 0.0009 0.0033 0.0025
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0047 0.013
Onchocerca volvulus 0.0153 0.1737 0.812
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0026 0.0073
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0164 0.0457
Onchocerca volvulus 0.0187 0.2139 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0308 0.3577 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0148 0.0799
Schistosoma mansoni laminin gamma-3 chain 0.0027 0.024 0.0233
Schistosoma mansoni hypothetical protein 0.0574 0.674 0.6738
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3577 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0176 0.0953
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0148 0.081
Echinococcus multilocularis microtubule associated protein 2 0.0364 0.4247 0.4247
Brugia malayi EGF-like domain containing protein 0.0027 0.024 0.1344
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0032 0.03 0.1641
Brugia malayi Trypsin family protein 0.0019 0.0143 0.0784
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0011 0.0054 0.0268
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.024
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0146 0.3193
Loa Loa (eye worm) hypothetical protein 0.0031 0.0293 0.1583
Schistosoma mansoni cathepsin F (C01 family) 0.0009 0.0026 0.0018
Schistosoma mansoni ap endonuclease 0.002 0.0164 0.0156
Mycobacterium ulcerans aldehyde dehydrogenase 0.0032 0.03 0.1641
Entamoeba histolytica protein kinase, putative 0.0011 0.0047 0.0109
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0009 0.0033 0.0054
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0018 0.013 0.0363
Loa Loa (eye worm) hypothetical protein 0.0048 0.0487 0.263
Brugia malayi Cytochrome P450 family protein 0.0019 0.0146 0.0797
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0148 0.014
Loa Loa (eye worm) hypothetical protein 0.0009 0.0028 0.0152
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0009 0.0024 0.0093
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0047 0.0039
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0009 0.0028 0.0152
Loa Loa (eye worm) ctsf protein 0.0009 0.0026 0.0141
Mycobacterium tuberculosis Probable dehydrogenase 0.0057 0.0597 0.3407
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0041 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0026 0.0073
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0009 0.0033 0.0054
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Schistosoma mansoni polycystin 1-related 0.0153 0.1737 0.173
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.1707 1
Brugia malayi cytoplasmic intermediate filament protein 0.0012 0.0058 0.029
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0011 0.0054 0.0177
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0016 0.0107 0.01
Brugia malayi Cytochrome P450 family protein 0.0009 0.0033 0.0145
Echinococcus granulosus neurogenic locus notch protein 0.0027 0.024 0.024
Brugia malayi Variant SH3 domain containing protein 0.0008 0.0019 0.0067
Echinococcus granulosus intermediate filament protein 0.0021 0.0176 0.0176
Brugia malayi Protein kinase domain containing protein 0.0011 0.0047 0.0224
Echinococcus granulosus cathepsin L cysteine proteinase 0.0009 0.0026 0.0026
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0009 0.0033 0.0054
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0118 0.1327 0.1327
Loa Loa (eye worm) doublecortin family protein 0.0153 0.1737 0.9386
Echinococcus multilocularis N chimaerin 0.0008 0.0019 0.0019
Brugia malayi ecdysone receptor 0.0009 0.0028 0.0117
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3577 1
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0011 0.0047 0.0252
Schistosoma mansoni hypothetical protein 0.0162 0.1851 0.1844
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0045 0.0456 0.6716
Loa Loa (eye worm) hypothetical protein 0.0019 0.0143 0.0775
Schistosoma mansoni notch 0.0027 0.024 0.0233
Plasmodium vivax glutathione reductase, putative 0.0025 0.0217 0.1131
Schistosoma mansoni dihydroorotate dehydrogenase 0.0045 0.0456 0.0449
Loa Loa (eye worm) nuclear hormone receptor 0.0009 0.0028 0.0152
Leishmania major cathepsin L-like protease 0.0034 0.0321 0.7039
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0057 0.0597 0.3407
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0031 0.0286 0.6279
Brugia malayi EGF-like domain containing protein 0.0027 0.024 0.1344
Loa Loa (eye worm) hypothetical protein 0.0019 0.0148 0.0799
Toxoplasma gondii MAC/Perforin domain-containing protein 0.0063 0.0675 1
Echinococcus granulosus neurogenic locus notch protein 0.0027 0.024 0.024
Brugia malayi Thioredoxin reductase 0.0025 0.0217 0.1213
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0057 0.0597 0.3407
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0321 0.6876
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0146 0.0724
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Leishmania major protein kinase, putative 0.0007 0.0006 0.0121
Echinococcus multilocularis fibrillin 1 0.0031 0.0293 0.0293
Echinococcus multilocularis unc 13 (munc13) 0.0009 0.0026 0.0026
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0057 0.0597 0.3499
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0009 0.0026 0.0013
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0143 0.0136
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0143 0.0136
Loa Loa (eye worm) hypothetical protein 0.0031 0.0293 0.1583
Entamoeba histolytica cysteine protease, putative 0.0009 0.0026 0.0051
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0009 0.0033 0.0054
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0009 0.0033 0.0054
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0143 0.0136
Brugia malayi hypothetical protein 0.001 0.0041 0.0191
Loa Loa (eye worm) thioredoxin reductase 0.0025 0.0217 0.1175
Echinococcus multilocularis protein kinase c iota type 0.0018 0.0133 0.0133
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0143 0.0136
Toxoplasma gondii thioredoxin reductase 0.0025 0.0217 0.3142
Schistosoma mansoni loxhd1 0.0153 0.1737 0.173
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0011 0.0047 0.0047
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0019 0.0148 0.0799
Loa Loa (eye worm) hypothetical protein 0.0021 0.0172 0.0928
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0019 0.0148 0.0799
Brugia malayi Hr1 repeat family protein 0.0011 0.0047 0.0224
Plasmodium falciparum perforin-like protein 1 0.0063 0.0675 0.3802
Onchocerca volvulus 0.0021 0.0176 0.0825
Brugia malayi C1-like domain containing protein 0.0008 0.0013 0.0032
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.0011 0.0057 0.0774
Echinococcus granulosus raf serine:threonine protein kinase 0.0007 0.0008 0.0008
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0045 0.0456 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0009 0.0033 0.0721
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0028 0.0028
Brugia malayi Cathepsin L-like precursor 0.0009 0.0026 0.0106
Onchocerca volvulus 0.0009 0.0026 0.0122
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0063 0.0673 0.3855
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0011 0.0054 0.0701
Onchocerca volvulus 0.0027 0.024 0.1123
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0143 0.0136
Leishmania major trypanothione reductase 0.0025 0.0217 0.477
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0148 0.0148
Schistosoma mansoni atypical protein kinase C 0.0018 0.0133 0.0126
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0009 0.0033 0.0054
Loa Loa (eye worm) hypothetical protein 0.0086 0.0939 0.5077
Brugia malayi hypothetical protein 0.0124 0.1397 0.8032
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0067 0.0717 0.0717
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0016 0.0113 0.0528
Toxoplasma gondii cytochrome p450 superfamily protein 0.0009 0.0033 0.0376
Onchocerca volvulus 0.0009 0.0028 0.0131
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0032 0.03 0.03
Giardia lamblia High cysteine protein 0.0027 0.024 0.0609
Leishmania major cathepsin L-like protease 0.0009 0.0026 0.0572
Toxoplasma gondii AGC kinase 0.0011 0.0047 0.0582
Echinococcus granulosus cytochrome P450 2K1 0.0009 0.0033 0.0033
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0028 0.0028
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0007 0.0006 0.0121
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0009 0.0024 0.0522
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0148 0.0148
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0148 0.0691
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0148 0.0148
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0148 0.0148
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0109 0.122 0.6591
Brugia malayi Protein kinase domain containing protein 0.0008 0.0013 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0026 0.0073
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0009 0.0026 0.0013
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0009 0.0024 0.0522
Schistosoma mansoni lamin 0.0021 0.0176 0.0169
Onchocerca volvulus Arrow homolog 0.0031 0.0293 0.1369
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0009 0.0024 0.0522
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0321 0.6876
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0009 0.0026 0.0073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3577 1
Echinococcus granulosus single minded 2 0.0019 0.0146 0.0146
Brugia malayi Delta serrate ligand family protein 0.0027 0.024 0.1344
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0009 0.0026 0.0073
Echinococcus granulosus protein jagged 2 0.0027 0.024 0.024
Plasmodium falciparum LCCL domain-containing protein 0.0153 0.1737 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0027 0.0243 0.1314
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0009 0.0033 0.0054
Chlamydia trachomatis DNA polymerase I 0.0016 0.0113 0.167
Mycobacterium ulcerans 5'-3' exonuclease 0.0011 0.0057 0.0199
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0019 0.0143 0.0136
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0009 0.0033 0.0054
Echinococcus multilocularis glycoprotein Antigen 5 0.0019 0.0143 0.0143
Brugia malayi RhoGAP domain containing protein 0.0008 0.0019 0.0067
Schistosoma mansoni coup transcription factor 0.0019 0.0148 0.014
Echinococcus multilocularis mitogen activated protein kinase 3 0.0027 0.0243 0.0243
Schistosoma mansoni hypothetical protein 0.0153 0.1737 0.173
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0009 0.0033 0.0054
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.1707 1
Leishmania major cathepsin L-like protease 0.0009 0.0026 0.0572
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0027 0.024 0.1123
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0045 0.0456 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0041 0.0412 0.2224
Echinococcus multilocularis RNA directed DNA polymerase 0.0048 0.0487 0.0487
Toxoplasma gondii kringle domain-containing protein 0.0041 0.0412 0.605
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0148 0.0799
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0118 0.1327 0.7171
Loa Loa (eye worm) hypothetical protein 0.0009 0.0028 0.0152
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0148 0.0148
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0143 0.0143
Loa Loa (eye worm) trypsin family protein 0.0019 0.0143 0.0775
Loa Loa (eye worm) Notch2 0.0027 0.024 0.1298
Loa Loa (eye worm) hypothetical protein 0.0019 0.0148 0.0799
Trypanosoma cruzi cysteine peptidase, putative 0.0009 0.0026 0.0572
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0028 0.002
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0148 0.014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3577 1
Echinococcus multilocularis neurogenic locus notch protein 0.0027 0.024 0.024
Loa Loa (eye worm) AGC/PKN protein kinase 0.0011 0.0047 0.0252
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0019 0.0151 0.0818
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0011 0.0057 0.1256
Loa Loa (eye worm) hypothetical protein 0.0153 0.1737 0.9386
Schistosoma mansoni single-minded 0.0026 0.0225 0.0217
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0148 0.0799
Trypanosoma brucei importin beta-1 subunit, putative 0.0015 0.0102 0.1806
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0008 0.0013 0.0072
Brugia malayi Trypsin family protein 0.0019 0.0143 0.0784
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0063 0.0673 0.3941
Trichomonas vaginalis glutathione reductase, putative 0.0009 0.0024 0.0067
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0009 0.0024 0.0024
Schistosoma mansoni nuclear receptor 0.0009 0.0028 0.002
Brugia malayi Pre-SET motif family protein 0.0109 0.122 0.7009
Giardia lamblia Kinase, CMGC MAPK 0.0027 0.0243 0.0617
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0009 0.0033 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0321 0.6876
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0009 0.0033 0.0054
Schistosoma mansoni lamin 0.0021 0.0176 0.0169
Echinococcus multilocularis serine:threonine protein kinase N2 0.0011 0.0047 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0026 0.0073
Loa Loa (eye worm) hypothetical protein 0.0055 0.0573 0.3099
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0015 0.0101 0.0101
Trypanosoma cruzi trypanothione reductase, putative 0.0009 0.0024 0.0522
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0027 0.0243 0.5332
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0026 0.0073
Echinococcus granulosus cathepsin l1 0.0009 0.0026 0.0026
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0028 0.0028
Loa Loa (eye worm) cysteine protease 0.0009 0.0026 0.0141
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0148 0.081
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0024 0.0522
Brugia malayi nuclear receptor NHR-88 0.0019 0.0148 0.081
Echinococcus granulosus neural cadherin 0.0027 0.024 0.024
Brugia malayi nuclear receptor NHR-67 0.0009 0.0028 0.0117
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0009 0.0033 0.0054
Loa Loa (eye worm) hypothetical protein 0.0031 0.0293 0.1583
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0143 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0009 0.0026 0.0073
Echinococcus multilocularis mitogen activated protein kinase 0.0027 0.0243 0.0243
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0321 0.6876
Echinococcus granulosus lamin 0.0021 0.0176 0.0176
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0027 0.024 0.1344
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0045 0.0456 0.2592
Onchocerca volvulus Cathepsin F homolog 0.0009 0.0026 0.0122
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.002 0.0157 0.0419
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0008 0.0013 0.0032
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0308 0.3577 1
Toxoplasma gondii calcium binding egf domain-containing protein 0.0031 0.0293 0.4272
Echinococcus granulosus tissue type plasminogen activator 0.0041 0.0412 0.0412
Onchocerca volvulus 0.0009 0.0026 0.0122
Echinococcus granulosus protein jagged 1 0.0027 0.024 0.024
Onchocerca volvulus 0.0007 0.0008 0.0037
Leishmania major cathepsin L-like protease 0.0034 0.0321 0.7039
Echinococcus granulosus glycoprotein Antigen 5 0.0019 0.0143 0.0143
Loa Loa (eye worm) STAT protein 0.0051 0.0529 0.286
Echinococcus multilocularis serine:threonine protein kinase N2 0.0011 0.0047 0.0047
Echinococcus granulosus NDR protein kinase 0.0011 0.0047 0.0047
Schistosoma mansoni protein kinase C mu 0.0008 0.0013 0.0006
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0011 0.0054 0.0177
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0009 0.0026 0.0141
Brugia malayi notch-like transmembrane receptor 0.0027 0.024 0.1344
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0148 0.014
Echinococcus multilocularis fibropellin Ia 0.0027 0.024 0.024
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0019 0.0143 0.0784
Trichomonas vaginalis mercuric reductase, putative 0.0009 0.0024 0.0067
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0008 0.0013 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0047 0.0039
Echinococcus multilocularis transmembrane protease serine 3 0.0019 0.0143 0.0143
Echinococcus granulosus GTP binding nuclear protein Ran 0.0011 0.0054 0.0054
Brugia malayi nuclear hormone receptor 0.0009 0.0028 0.0117
Echinococcus multilocularis importin subunit beta 1 0.0015 0.0102 0.0102
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0009 0.0033 0.0054
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0024 0.0522
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0027 0.0243 0.3527
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0008 0.0013 0.0072
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0009 0.0033 0.0054
Toxoplasma gondii NADPH-glutathione reductase 0.0009 0.0024 0.024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0143 0.0775
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0021 0.0176 0.0953
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0009 0.0033 0.0054
Toxoplasma gondii perforin-like protein PLP1 0.0063 0.0675 1
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0045 0.0456 1
Trichomonas vaginalis importin beta-1, putative 0.0012 0.0068 0.0189
Schistosoma mansoni hypothetical protein 0.0027 0.024 0.0233
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0148 0.081
Echinococcus multilocularis Rac GTPase activating protein 1 0.0007 0.0008 0.0008
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0148 0.014
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0041 0.0191
Leishmania major cathepsin L-like protease 0.0009 0.0026 0.0572
Leishmania major cytochrome p450-like protein 0.0009 0.0033 0.0721
Echinococcus multilocularis snurportin 1 0.0162 0.1851 0.1851
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0028 0.002
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0028 0.0028
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.0157 0.0157
Echinococcus multilocularis protein kinase c eta type 0.0007 0.0008 0.0008
Leishmania major cysteine peptidase A (CPA) 0.0009 0.0026 0.0572
Trichomonas vaginalis CMGC family protein kinase 0.0027 0.0243 0.068
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0013 0.0006
Loa Loa (eye worm) hypothetical protein 0.0009 0.0028 0.0152
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0148 0.0148
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0016 0.0107 0.1492
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0009 0.0024 0.0522
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0027 0.0243 0.5332
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0148 0.081
Brugia malayi Calcium binding EGF domain containing protein 0.0027 0.024 0.1344
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0028 0.0117
Trichomonas vaginalis set domain proteins, putative 0.0124 0.1399 0.3912
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0009 0.0033 0.0054
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Mycobacterium ulcerans aldehyde dehydrogenase 0.0032 0.03 0.1641
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0214
Mycobacterium ulcerans hypothetical protein 0.0019 0.0143 0.071
Schistosoma mansoni hypothetical protein 0.0027 0.024 0.0233
Schistosoma mansoni hypothetical protein 0.0041 0.0412 0.0404
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0009 0.0026 0.0026
Brugia malayi Calcium binding EGF domain containing protein 0.0027 0.024 0.1344
Loa Loa (eye worm) hypothetical protein 0.0019 0.0143 0.0775
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Onchocerca volvulus 0.0019 0.0143 0.067
Loa Loa (eye worm) hypothetical protein 0.0009 0.0026 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0026 0.0073
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0148 0.014
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0047 0.0039
Brugia malayi Intermediate filament tail domain containing protein 0.0021 0.0176 0.0975
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0032 0.03 0.03
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0164 0.0393
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0028 0.0131
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0009 0.0033 0.0054
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0321 0.7039
Loa Loa (eye worm) hypothetical protein 0.0041 0.0412 0.2224
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0009 0.0026 0.0141
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0143 0.0136
Onchocerca volvulus 0.0019 0.0146 0.0681
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0146 0.2818
Loa Loa (eye worm) hypothetical protein 0.0019 0.0143 0.0775
Onchocerca volvulus 0.0153 0.1737 0.812
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0164 0.083
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0027 0.0243 0.5332
Brugia malayi Importin beta-1 subunit 0.0015 0.0102 0.0544
Echinococcus granulosus lipoxygenase domain containing protein 0.0153 0.1737 0.1737
Echinococcus granulosus Diacylglycerol kinase theta 0.0007 0.0008 0.0008
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0148 0.0148
Loa Loa (eye worm) AGC/AKT protein kinase 0.0011 0.0047 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0148 0.081
Onchocerca volvulus Cathepsin L homolog 0.0009 0.0026 0.0122
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.002 0.0157 0.044
Toxoplasma gondii cathepsin CPL 0.0009 0.0026 0.0274
Onchocerca volvulus 0.0016 0.0107 0.0502
Echinococcus granulosus Protein kinase C brain isozyme 0.0067 0.0717 0.0717
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0148 0.0691
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0009 0.0026 0.0073
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0009 0.0033 0.0054
Schistosoma mansoni aldehyde dehydrogenase 0.0032 0.03 0.0292
Brugia malayi p70 ribosomal S6 kinase beta 0.0011 0.0047 0.0224
Schistosoma mansoni ap endonuclease 0.002 0.0164 0.0156
Leishmania major protein kinase, putative 0.0009 0.003 0.0657
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0148 0.0691
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0008 0.0019 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0148 0.0148
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0027 0.0243 0.5332
Echinococcus multilocularis serine threonine protein kinase 0.006 0.063 0.063
Brugia malayi Zinc finger, C2H2 type family protein 0.0018 0.013 0.0706
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0321 0.6876
Echinococcus multilocularis musashi 0.0021 0.0176 0.0176
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0118 0.1327 0.763
Brugia malayi Cytochrome P450 family protein 0.0029 0.0271 0.1522
Onchocerca volvulus 0.0009 0.0026 0.0122
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0028 0.0117
Brugia malayi STAT protein, DNA binding domain containing protein 0.0051 0.0529 0.3015
Onchocerca volvulus 0.0027 0.024 0.1123
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0042
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0028 0.0028
Schistosoma mansoni protein kinase C 0.0009 0.0026 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0221
Brugia malayi ecdysteroid receptor 0.0019 0.0148 0.081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0009 0.0026 0.0073
Onchocerca volvulus 0.0019 0.0148 0.0691
Brugia malayi Protein kinase c protein 2 0.0057 0.0597 0.3407
Onchocerca volvulus 0.0027 0.024 0.1123
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0143 0.0136
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0028 0.0117
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0148 0.0148
Loa Loa (eye worm) RasGEF domain-containing protein 0.0008 0.0021 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0148 0.081
Schistosoma mansoni survival motor neuron protein 0.0025 0.0222 0.0214
Schistosoma mansoni serine/threonine kinase 0.0011 0.0047 0.0039
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0024 0.0522
Onchocerca volvulus Slit protein homolog 0.0027 0.024 0.1123
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0009 0.0033 0.0054
Echinococcus multilocularis serine:threonine protein kinase 38 0.0011 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0009 0.0033 0.0025
Loa Loa (eye worm) hypothetical protein 0.0153 0.1737 0.9386
Loa Loa (eye worm) hypothetical protein 0.0019 0.0148 0.0799
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0009 0.0033 0.0054
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0028 0.0028
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0026 0.0051
Echinococcus granulosus notch 0.0027 0.024 0.024
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0031 0.0293 0.1583
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0019 0.0143 0.0143
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Onchocerca volvulus Cathepsin L homolog 0.0009 0.0026 0.0122
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0047 0.013
Leishmania major dihydroorotate dehydrogenase 0.0045 0.0456 1
Plasmodium falciparum importin beta, putative 0.0015 0.0102 0.0455
Schistosoma mansoni rab6-interacting 0.0153 0.1737 0.173
Entamoeba histolytica protein kinase, putative 0.0011 0.0047 0.0109
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0095 0.1053 0.4921
Onchocerca volvulus 0.0007 0.0008 0.0037
Echinococcus granulosus mitogen activated protein kinase 0.0027 0.0243 0.0243
Brugia malayi intermediate filament protein 0.0021 0.0176 0.0975
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0009 0.0033 0.0054
Brugia malayi EGF-like domain containing protein 0.0027 0.024 0.1344
Echinococcus granulosus Mastin 0.0019 0.0143 0.0143
Echinococcus multilocularis protein jagged 2 0.0027 0.024 0.024
Onchocerca volvulus 0.0124 0.1399 0.6541
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0009 0.0033 0.0054
Plasmodium falciparum perforin-like protein 5 0.0063 0.0675 0.3802
Loa Loa (eye worm) intermediate filament protein 0.0021 0.0176 0.0953
Echinococcus multilocularis lamin 0.0021 0.0176 0.0176
Echinococcus multilocularis neural cadherin 0.0027 0.024 0.024
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0011 0.0047 0.0047
Onchocerca volvulus Putative cubilin 0.0027 0.024 0.1123
Loa Loa (eye worm) hypothetical protein 0.0009 0.0028 0.0152
Echinococcus multilocularis enteropeptidase 0.0019 0.0143 0.0143
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0041 0.0041
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0162 0.1851 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0143 0.0136
Echinococcus multilocularis notch 0.0027 0.024 0.024
Echinococcus multilocularis Diacylglycerol kinase theta 0.0007 0.0008 0.0008
Onchocerca volvulus 0.0027 0.024 0.1123
Echinococcus granulosus cytoplasmic intermediate filament protein 0.001 0.0044 0.0044
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0028 0.0117
Loa Loa (eye worm) hypothetical protein 0.0009 0.0028 0.0152
Brugia malayi Pre-SET motif family protein 0.0016 0.0107 0.0576
Loa Loa (eye worm) DR-78 0.0009 0.0028 0.0152
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0148 0.0148
Schistosoma mansoni egf-like domain protein 0.0031 0.0293 0.0285
Treponema pallidum DNA polymerase I (polA) 0.0016 0.0113 0.025
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0009 0.0033 0.0054
Onchocerca volvulus 0.0009 0.0026 0.0121
Echinococcus granulosus protein jagged 2 0.0027 0.024 0.024
Brugia malayi cytochrome P450 0.0009 0.0033 0.0145
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0009 0.0026 0.014
Plasmodium falciparum perforin-like protein 4 0.0063 0.0675 0.3802
Loa Loa (eye worm) hypothetical protein 0.0009 0.0034 0.0183
Toxoplasma gondii aldehyde dehydrogenase 0.0032 0.03 0.4379
Echinococcus granulosus Tolloid protein 1 0.0031 0.0293 0.0293
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0009 0.0033 0.0054
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0041 0.0033
Echinococcus multilocularis cysteine protease 0.0009 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0221
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0148 0.014
Brugia malayi Protein kinase domain containing protein 0.0041 0.0412 0.2335
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0026 0.0073
Brugia malayi EGF-like domain containing protein 0.0027 0.024 0.1344
Onchocerca volvulus 0.0019 0.0143 0.067
Echinococcus granulosus Polycystic kidney disease protein 0.0153 0.1737 0.1737
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0148 0.0799
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0148 0.0799
Onchocerca volvulus 0.0009 0.0026 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0148 0.0799
Leishmania major hypothetical protein, conserved 0.0041 0.0412 0.9025
Echinococcus multilocularis macrophage expressed protein 0.0574 0.674 0.674
Onchocerca volvulus 0.0021 0.0176 0.0825
Echinococcus multilocularis neurogenic locus protein delta 0.0027 0.024 0.024
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0011 0.0047 0.0047
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0164 0.0884
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0164 0.3234
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0009 0.0033 0.021
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0028 0.0117
Onchocerca volvulus 0.0019 0.0143 0.067
Plasmodium falciparum perforin-like protein 3 0.0063 0.0675 0.3802
Schistosoma mansoni hypothetical protein 0.0019 0.0143 0.0136
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0045 0.0456 1
Echinococcus multilocularis neurogenic locus protein delta 0.0027 0.024 0.024
Echinococcus granulosus snurportin 1 0.0162 0.1851 0.1851
Echinococcus multilocularis slit 2 protein 0.0027 0.024 0.024
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0011 0.0057 0.0195
Echinococcus multilocularis tissue type plasminogen activator 0.0041 0.0412 0.0412
Brugia malayi Cathepsin L-like precursor 0.0009 0.0026 0.0106
Brugia malayi EGF-like domain containing protein 0.0027 0.024 0.1344
Brugia malayi hypoxia-induced factor 1 0.0079 0.0861 0.4932
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0009 0.0026 0.0026
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0164 0.0164
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.0011 0.0057 0.1256
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0042
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0012 0.0058 0.0313
Loa Loa (eye worm) hypothetical protein 0.0019 0.0143 0.0775
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0008 0.0013 0.0013
Leishmania major cathepsin L-like protease 0.0009 0.0026 0.0572
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0019 0.0143 0.0143
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0028 0.0028
Brugia malayi protein kinase C II. 0.0019 0.0151 0.083
Mycobacterium tuberculosis Probable oxidoreductase 0.0063 0.0673 0.3855
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0011 0.0057 0.0195
Plasmodium vivax perforin-like protein 5 0.0063 0.0675 0.3802
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0027 0.0243 0.5075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0148 0.0799
Schistosoma mansoni notch 0.0027 0.024 0.0233
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0026 0.0106
Loa Loa (eye worm) glutathione reductase 0.0025 0.0217 0.1175
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0026 0.0073
Plasmodium falciparum cysteine proteinase falcipain 3 0.0009 0.0026 0.0013
Echinococcus multilocularis neurogenic locus notch protein 4 0.0027 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0009 0.0028 0.0152
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.1298
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.005 0.051 0.2757
Loa Loa (eye worm) hypothetical protein 0.0009 0.0028 0.0152
Onchocerca volvulus 0.0009 0.0026 0.0122
Entamoeba histolytica Ran family GTPase 0.0011 0.0054 0.013
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0143 0.0136
Toxoplasma gondii EGF family domain-containing protein 0.0027 0.024 0.3483
Plasmodium falciparum cysteine repeat modular protein 1 0.0041 0.0412 0.2263
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0047 0.013
Brugia malayi glutathione reductase 0.0025 0.0217 0.1213
Schistosoma mansoni hypothetical protein 0.0027 0.024 0.0233
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0045 0.0456 0.2568
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0148 0.014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0107 0.058
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0011 0.0054 0.1187
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0008 0.0019 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0047 0.013
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0032 0.03 0.6579
Loa Loa (eye worm) hypothetical protein 0.0095 0.1053 0.5688
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.0157 0.0157
Echinococcus multilocularis myotubularin protein 13 0.0007 0.0008 0.0008
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0041 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0148 0.0799
Onchocerca volvulus 0.0019 0.0143 0.067
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0041 0.0221
Brugia malayi hypothetical protein 0.0009 0.0028 0.0117
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0011 0.0054 0.1187
Loa Loa (eye worm) notch protein 0.0027 0.024 0.1298
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0057 0.0597 0.3407
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0011 0.0054 0.0054
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0025 0.0217 0.1151
Brugia malayi EGF-like domain containing protein 0.0027 0.024 0.1344
Leishmania major cytochrome p450-like protein 0.0009 0.0033 0.0721
Trichomonas vaginalis CMGC family protein kinase 0.0027 0.0243 0.068
Plasmodium vivax perforin-like protein 2 0.0063 0.0675 0.3802
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0011 0.0054 0.0293
Trichomonas vaginalis CMGC family protein kinase 0.0027 0.0243 0.068
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0148 0.0148
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0143 0.0136
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0018 0.013 0.0363
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0011 0.0047 0.0047
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0849 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0146 0.0787
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.001 0.0041 0.0115
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0031 0.0293 0.1583
Loa Loa (eye worm) hypothetical protein 0.0009 0.0028 0.0152
Loa Loa (eye worm) fibroinase 0.0009 0.0026 0.0141
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0028 0.0117
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0009 0.0024 0.024
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0047 0.013
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0009 0.0024 0.0522
Schistosoma mansoni notch 0.0027 0.024 0.0233
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0164 0.083
Leishmania major cytochrome p450-like protein 0.0019 0.0146 0.3193
Echinococcus granulosus lamin dm0 0.0021 0.0176 0.0176
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0016 0.0107 0.0107
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0009 0.0033 0.0054
Brugia malayi Protein kinase domain containing protein 0.0011 0.0047 0.0224
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0011 0.0047 0.0252
Schistosoma mansoni ran 0.0011 0.0054 0.0046
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0009 0.0033 0.0054
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0031 0.0293 0.1649
Brugia malayi hypothetical protein 0.0086 0.0939 0.5388
Schistosoma mansoni ran 0.0011 0.0054 0.0046
Trypanosoma cruzi major cysteine proteinase, putative 0.0026 0.0235 0.5163
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0042
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0148 0.014
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.1707 1
Schistosoma mansoni notch 0.0027 0.024 0.0233
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0045 0.0456 0.2671
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0007 0.0006 0.0121
Mycobacterium tuberculosis Probable 5'-3' exonuclease 0.0011 0.0057 0.0199
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0018 0.013 0.0363
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0009 0.0033 0.0054
Echinococcus multilocularis protein kinase c epsilon type 0.0019 0.0151 0.0151
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0164 0.3588
Echinococcus multilocularis cysteine protease 0.0009 0.0026 0.0026
Echinococcus granulosus unc 13 munc13 0.0009 0.0026 0.0026
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.0157 0.0157
Brugia malayi hypothetical protein 0.0019 0.0143 0.0784
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0009 0.0024 0.0353
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0042
Echinococcus multilocularis 0.0009 0.0033 0.0033
Schistosoma mansoni cathepsin F (C01 family) 0.0009 0.0026 0.0018
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0009 0.0033 0.0054

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 96 nM Displacement of [H-20]phorbol12,13-dibutyrate (PDBU) from Protein kinase C alpha ChEMBL. 8568806
Ki (binding) = 96 nM Affinity for protein kinase-C alpha (PK-C alpha) ChEMBL. 10966739
Ki (binding) = 96 nM Displacement of [H-20]phorbol12,13-dibutyrate (PDBU) from Protein kinase C alpha ChEMBL. 8568806
Ki (binding) = 96 nM Affinity for protein kinase-C alpha (PK-C alpha) ChEMBL. 10966739

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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