Detailed information for compound 1647150

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 291.389 | Formula: C14H13NO2S2
  • H donors: 0 H acceptors: 2 LogP: 3.72 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CS/C(=N\S(=O)(=O)c1ccccc1)/c1ccccc1
  • InChi: 1S/C14H13NO2S2/c1-18-14(12-8-4-2-5-9-12)15-19(16,17)13-10-6-3-7-11-13/h2-11H,1H3/b15-14-
  • InChiKey: SNHKZOIZLZGTEJ-PFONDFGASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ABC1 family protein 0.0043 0.0074 0.0099
Loa Loa (eye worm) norepinephrine transporter 0.0137 0.0323 0.0322
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0023 0.0019 0.0019
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0035 0.005 0.071
Loa Loa (eye worm) hypothetical protein 0.048 0.1232 0.1232
Brugia malayi G-protein coupled receptor 0.0037 0.0056 0.0056
Trypanosoma brucei developmentally regulated phosphoprotein 0.0504 0.1296 0.1282
Loa Loa (eye worm) hypothetical protein 0.0818 0.2128 0.2128
Echinococcus granulosus g protein coupled receptor 0.0037 0.0056 0.0056
Echinococcus multilocularis serotonin transporter 0.0137 0.0323 0.0322
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0117 0.0268 0.0268
Trichomonas vaginalis PIKK family atypical protein kinase 0.322 0.8505 0.8503
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0316 0.0797 0.0783
Loa Loa (eye worm) hypothetical protein 0.0043 0.0074 0.0073
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0062 0.0122 0.0106
Echinococcus granulosus geminin 0.0319 0.0805 0.0805
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.048 0.1232 0.1218
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0019 0.0004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0112 0.0255 0.0236
Brugia malayi hypothetical protein 0.0037 0.0056 0.0056
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0032 0.0032
Onchocerca volvulus 0.0037 0.0056 0.0516
Trichomonas vaginalis PIKK family atypical protein kinase 0.2256 0.5946 0.5939
Trichomonas vaginalis PIKK family atypical protein kinase 0.0746 0.1937 0.1924
Leishmania major heat shock protein 83-1 0.0028 0.0033 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.3018 0.7969 0.7966
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0254 0.0634 0.0633
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0028 0.0033 0.0017
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0023 0.002 0.002
Leishmania major phosphatidylinositol kinase, putative 0.0254 0.0634 0.0633
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0028 0.0033 1
Leishmania major hypothetical protein, conserved 0.0043 0.0074 0.0073
Loa Loa (eye worm) transcription factor SMAD2 0.0225 0.0556 0.0556
Loa Loa (eye worm) phosphatidylinositol 3 0.3784 1 1
Leishmania major heat shock protein 83-1 0.0028 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Leishmania major heat shock protein 83-1 0.0028 0.0033 0.0032
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0232 0.0574 0.0573
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0023 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0379 0.0965 0.0965
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0037 0.0056 0.0056
Onchocerca volvulus 0.0254 0.0634 0.8799
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0054 0.0054
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0084 0.0182 0.0182
Trichomonas vaginalis PIKK family atypical protein kinase 0.2262 0.5962 0.5955
Schistosoma mansoni hypothetical protein 0.0563 0.1453 0.1453
Loa Loa (eye worm) melatonin receptor type 1A 0.0037 0.0056 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0818 0.2128 0.2116
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0074 0.105
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0074 0.0058
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0178 0.043 0.043
Schistosoma mansoni endoplasmin 0.0028 0.0033 0.0032
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0275 0.0688 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0044 0.1538
Leishmania major heat shock protein 83-1 0.0028 0.0033 0.0032
Toxoplasma gondii heat shock protein HSP90 0.0028 0.0033 0.0044
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0028 0.0033 0.1081
Trichomonas vaginalis glucosylceramidase, putative 0.0232 0.0574 0.0559
Onchocerca volvulus 0.0037 0.0056 0.0516
Plasmodium falciparum DNA topoisomerase 2 0.0028 0.0033 0.0472
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0044 0.0624
Plasmodium falciparum acyl-CoA synthetase 0.0082 0.0177 0.2565
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.005 0.005
Plasmodium falciparum heat shock protein 90 0.0028 0.0033 0.0472
Schistosoma mansoni voltage-gated potassium channel 0.0127 0.0296 0.0296
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0044 0.0624
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0112 0.0255 0.0255
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0056 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.206 0.5425 0.5418
Echinococcus granulosus lamin 0.0028 0.0032 0.0032
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1583 0.4159 0.415
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Trichomonas vaginalis endoplasmin, putative 0.0028 0.0033 0.0017
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0346 0.0877 0.086
Loa Loa (eye worm) hypothetical protein 0.0032 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.002
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0019 0.0266
Entamoeba histolytica DNA topoisomerase II, putative 0.0028 0.0033 0.0017
Mycobacterium tuberculosis Conserved protein 0.0028 0.0033 0.046
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.011 0.025 0.3896
Trichomonas vaginalis conserved hypothetical protein 0.0563 0.1453 0.1439
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0056 0.0056
Brugia malayi sulfakinin receptor protein 0.0037 0.0056 0.0056
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0024 0.0021 0.0242
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0074 0.0073
Entamoeba histolytica hypothetical protein 0.0067 0.0135 0.0119
Mycobacterium ulcerans hypothetical protein 0.0043 0.0074 0.2729
Trypanosoma brucei heat shock protein 90, putative 0.0028 0.0033 0.0017
Entamoeba histolytica acyl-CoA synthetase, putative 0.0112 0.0256 0.0241
Toxoplasma gondii type I fatty acid synthase, putative 0.0028 0.0033 0.0044
Echinococcus granulosus mitogen activated protein kinase 14 0.0112 0.0255 0.0255
Brugia malayi hypothetical protein 0.0037 0.0056 0.0056
Brugia malayi heat shock protein 90 0.0028 0.0033 0.0032
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0082 0.0177 0.2531
Entamoeba histolytica acyl-coA synthetase, putative 0.011 0.025 0.0235
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.0222 0.0222
Loa Loa (eye worm) phosphatidylinositol 3 0.0254 0.0634 0.0633
Mycobacterium ulcerans Type I modular polyketide synthase 0.0022 0.0017 0.0464
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0056 0.0056
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0035 0.005 0.1778
Mycobacterium ulcerans acetyl-CoA synthetase 0.0032 0.0044 0.1538
Loa Loa (eye worm) hypothetical protein 0.0042 0.0069 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.3784 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0152 0.0362 0.0347
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0023 0.002 0.002
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0074 0.0058
Echinococcus granulosus g protein coupled receptor 0.0037 0.0056 0.0056
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0028 0.0033 0.0017
Trypanosoma brucei heat shock protein, putative 0.0028 0.0033 0.0017
Schistosoma mansoni hypothetical protein 0.0037 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0054 0.0054
Loa Loa (eye worm) phosphatidylinositol kinase 0.0254 0.0634 0.0633
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0023 0.002 0.002
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0112 0.0255 0.024
Loa Loa (eye worm) hypothetical protein 0.0071 0.0147 0.0147
Onchocerca volvulus 0.0037 0.0056 0.0516
Echinococcus multilocularis hyperpolarization activated cyclic 0.0023 0.0019 0.0019
Schistosoma mansoni intermediate filament proteins 0.0028 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0046 0.0081 0.008
Loa Loa (eye worm) phosphatidylinositol 3 0.0254 0.0634 0.0633
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0112 0.0255 0.0239
Echinococcus granulosus somatostatin receptor 0.0037 0.0056 0.0056
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0074 0.2729
Schistosoma mansoni hypothetical protein 0.0067 0.0135 0.0135
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0112 0.0255 0.3527
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0056 0.0056
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0022 0.0017 0.0239
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0074 0.0058
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0275 0.0688 0.0687
Mycobacterium ulcerans polyketide synthase 0.0024 0.0021 0.0611
Trichomonas vaginalis glucosylceramidase, putative 0.0152 0.0362 0.0347
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1782 0.4688 0.4679
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.1298 0.3402 0.3392
Trypanosoma brucei DNA topoisomerase ii 0.0028 0.0033 0.0017
Trypanosoma cruzi DNA topoisomerase II, putative 0.0028 0.0033 0.0017
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0074 0.0073
Brugia malayi prolyl oligopeptidase family protein 0.006 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Echinococcus multilocularis mitogen activated protein kinase 11 0.0112 0.0255 0.0255
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0028 0.0033 0.018
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0032 0.0032
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0037 0.0056 0.0056
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0056 0.0056
Loa Loa (eye worm) beta-lactamase 0.0043 0.0074 0.0073
Echinococcus multilocularis mitogen activated protein kinase 14 0.0112 0.0255 0.0255
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0254 0.0634 0.0619
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0056 0.0056
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0056 0.0056
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0112 0.0255 0.024
Echinococcus granulosus serotonin receptor 0.0037 0.0056 0.0056
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0081 0.008
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.3784 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Leishmania major heat shock protein 83-1 0.0028 0.0033 0.0032
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0409 0.1045 0.103
Loa Loa (eye worm) hypothetical protein 0.0046 0.0079 0.0079
Echinococcus granulosus g protein coupled receptor 0.0037 0.0056 0.0056
Entamoeba histolytica hypothetical protein 0.0067 0.0135 0.0119
Loa Loa (eye worm) heat shock protein 90 0.0028 0.0033 0.0032
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.006 0.0117 0.0101
Plasmodium vivax DNA gyrase subunit B, putative 0.0028 0.0033 0.0211
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0056 0.0056
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0056 0.0056
Schistosoma mansoni acetyl-CoA synthetase 0.0032 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0019 0.0004
Brugia malayi Pre-SET motif family protein 0.0036 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0101 0.0227 0.0227
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0028 0.0033 0.0428
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.0384 0.0368
Mycobacterium leprae Polyketide synthase Pks13 0.0033 0.0046 0.0649
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0316 0.0797 0.0797
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0037 0.0056 0.0056
Brugia malayi AMP-binding enzyme family protein 0.0053 0.0099 0.0099
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0028 0.0033 0.1081
Echinococcus multilocularis Zinc finger, PHD finger 0.0275 0.0688 0.0687
Mycobacterium ulcerans two component regulator - sensor kinase 0.0028 0.0033 0.1081
Brugia malayi G protein-coupled receptor 0.0037 0.0056 0.0056
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0022 0.0017 0.0184
Plasmodium vivax amine transporter, putative 0.0023 0.002 0.0024
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0028 0.0033 0.018
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0019 0.0019
Leishmania major phosphatidylinositol 4-kinase, putative 0.0254 0.0634 0.0633
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0028 0.0033 0.046
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0037 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0032 0.0044 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0254 0.0634 0.0619
Loa Loa (eye worm) hypothetical protein 0.0028 0.0033 0.0032
Echinococcus multilocularis mitogen activated protein kinase 11 0.0112 0.0255 0.0255
Brugia malayi MH2 domain containing protein 0.0225 0.0556 0.0556
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0056 0.0056
Schistosoma mansoni pyruvate dehydrogenase 0.0476 0.1221 0.1221
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0094 0.0207 0.0191
Plasmodium vivax acetyl-CoA synthetase, putative 0.0032 0.0044 0.0381
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0056 0.0056
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0116 0.4439
Onchocerca volvulus 0.011 0.025 0.3302
Brugia malayi Melatonin receptor type 1A 0.0037 0.0056 0.0056
Chlamydia trachomatis DNA gyrase subunit B 0.0028 0.0033 0.0802
Trichomonas vaginalis PIKK family atypical protein kinase 0.2262 0.5962 0.5955
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Plasmodium vivax SET domain protein, putative 0.0036 0.0054 0.0529
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0275 0.0688 0.0673
Schistosoma mansoni heat shock protein 0.0028 0.0033 0.0032
Leishmania major heat shock protein 83-1 0.0028 0.0033 0.0032
Brugia malayi AKH receptor 0.0037 0.0056 0.0056
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0056 0.0056
Mycobacterium leprae Probable polyketide synthase Pks1 0.0024 0.0021 0.0242
Trichomonas vaginalis glucosylceramidase, putative 0.0152 0.0362 0.0347
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0032 0.0044 0.0044
Brugia malayi hypothetical protein 0.0037 0.0056 0.0056
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0022 0.0017 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.2825 0.7456 0.7452
Leishmania major 4-coumarate:coa ligase-like protein 0.011 0.025 0.025
Brugia malayi hypothetical protein 0.0037 0.0056 0.0056
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0504 0.1296 0.1296
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Trichomonas vaginalis glucosylceramidase, putative 0.0232 0.0574 0.0559
Schistosoma mansoni pyruvate dehydrogenase 0.0504 0.1296 0.1296
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0081 0.008
Giardia lamblia GTOR 0.3784 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0096 0.0214 0.0214
Onchocerca volvulus 0.0037 0.0056 0.0516
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0019 0.0513
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Trypanosoma brucei heat shock protein 90, putative 0.0028 0.0033 0.0017
Leishmania major heat shock protein 83-1 0.0028 0.0033 0.0032
Brugia malayi AMP-binding enzyme family protein 0.011 0.025 0.025
Toxoplasma gondii hypothetical protein 0.0023 0.002 0.0027
Mycobacterium tuberculosis Conserved hypothetical protein 0.0254 0.0634 0.911
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0056 0.0056
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0028 0.0033 1
Plasmodium vivax hypothetical protein 0.0254 0.0634 0.9193
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0032 0.0044 0.0044
Mycobacterium tuberculosis Conserved protein 0.0043 0.0074 0.105
Mycobacterium ulcerans beta-lactamase 0.0043 0.0074 0.2729
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0032 0.0044 0.0624
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0629 0.1627 0.1627
Loa Loa (eye worm) hypothetical protein 0.0082 0.0177 0.0176
Loa Loa (eye worm) hypothetical protein 0.0046 0.0081 0.008
Plasmodium vivax acyl-CoA synthetase, putative 0.0082 0.0177 0.2361
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0116 0.4439
Leishmania major developmentally regulated phosphoprotein-like protein 0.0504 0.1296 0.1296
Echinococcus multilocularis neuropeptide receptor A26 0.0037 0.0056 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.2825 0.7456 0.7452
Entamoeba histolytica hypothetical protein 0.0734 0.1908 0.1895
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0028 0.0033 0.1081
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0023 0.002 0.002
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1309 0.3432 0.3431
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0056 0.0056
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0056 0.0056
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0112 0.0255 0.0254
Trichomonas vaginalis PIKK family atypical protein kinase 0.2063 0.5433 0.5426
Trichomonas vaginalis PIKK family atypical protein kinase 0.206 0.5425 0.5418
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0035 0.005 0.071
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0032 0.0044 0.0028
Echinococcus granulosus hypothetical protein 0.0037 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.002
Loa Loa (eye worm) oxidoreductase 0.0032 0.0044 0.0044
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0028 0.0033 0.0428
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0023 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0054
Schistosoma mansoni neuropeptide receptor 0.0037 0.0056 0.0056
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0275 0.0688 0.0922
Onchocerca volvulus 0.0035 0.005 0.0428
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0037 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0043 0.0074 0.0073
Echinococcus granulosus sex peptide receptor 0.0037 0.0056 0.0056
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0028 0.0033 0.046
Toxoplasma gondii DNA topoisomerase 2, putative 0.0028 0.0033 0.0044
Trichomonas vaginalis esterase, putative 0.0043 0.0074 0.0058
Echinococcus granulosus 7tm_1 domain containing protein 0.0037 0.0056 0.0056
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0032 0.0044 0.0609
Echinococcus multilocularis voltage gated potassium channel 0.0034 0.0048 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.1298 0.3402 0.3392
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0084 0.0182 0.0182
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0112 0.0255 0.3699
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Echinococcus granulosus allatostatin A receptor 0.0037 0.0056 0.0056
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0032 0.0044 0.0059
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0023 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.006 0.0117 0.0101
Echinococcus multilocularis sex peptide receptor 0.0037 0.0056 0.0056
Echinococcus granulosus Dipeptidyl peptidase 9 0.006 0.0117 0.0117
Leishmania major hypothetical protein, conserved 0.0348 0.0882 0.0882
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0254 0.0634 0.0633
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0037 0.0056 0.0056
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0024 0.0021 0.0292
Schistosoma mansoni sodium/chloride dependent transporter 0.0023 0.002 0.002
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0275 0.0688 0.0673
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.3784 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0319 0.0805 0.0805
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.006 0.0117 0.0157
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0056 0.0056
Echinococcus granulosus fmrfamide receptor 0.0037 0.0056 0.0056
Onchocerca volvulus 0.0032 0.0044 0.0343
Schistosoma mansoni hypothetical protein 0.0046 0.0081 0.008
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Onchocerca volvulus 0.0028 0.0032 0.0174
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0032 0.0044 0.0028
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0028 0.0033 0.0017
Schistosoma mansoni immunophilin 0.0112 0.0255 0.0254
Loa Loa (eye worm) hypothetical protein 0.011 0.025 0.025
Echinococcus multilocularis musashi 0.0028 0.0032 0.0032
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0734 0.1908 0.1907
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0019 0.0003
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Brugia malayi hypothetical protein 0.0037 0.0056 0.0056
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0504 0.1296 0.1296
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0146 0.0345 0.0344
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0081 0.008
Trichomonas vaginalis receptor histidine kinase, putative 0.0028 0.0033 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0232 0.0574 0.0559
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0028 0.0033 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.2825 0.7456 0.7452
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0034 0.0048 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.2063 0.5433 0.5426
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0037 0.0056 0.0056
Trichomonas vaginalis sensor histidine kinase, putative 0.0028 0.0033 0.0017
Brugia malayi hypothetical protein 0.0037 0.0056 0.0056
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0019 0.0003
Onchocerca volvulus 0.0037 0.0056 0.0516
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0629 0.1627 0.1627
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0019 0.0003
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0275 0.0688 0.0687
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0056 0.0056
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0109 0.0247 0.0232
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0028 0.0033 0.0017
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0035 0.005 0.071
Schistosoma mansoni amine GPCR 0.0037 0.0056 0.0056
Echinococcus granulosus intermediate filament protein 0.0028 0.0032 0.0032
Schistosoma mansoni ap endonuclease 0.0023 0.0019 0.0018
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.135 0.354 0.353
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0019 0.0003
Schistosoma mansoni biogenic amine receptor 0.0037 0.0056 0.0056
Onchocerca volvulus 0.0037 0.0056 0.0516
Onchocerca volvulus 0.0043 0.0074 0.0768
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0254 0.0634 0.0619
Trichomonas vaginalis immunophilin, putative 0.0112 0.0255 0.0239
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0028 0.0033 0.018
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0056 0.0056
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0056 0.0056
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0019 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0056 0.0056
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0037 0.0056 0.0056
Brugia malayi Tachykinin-like peptides receptor 99D 0.0037 0.0056 0.0056
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0032 0.0452
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.002
Onchocerca volvulus 0.0037 0.0056 0.0516
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0084 0.0182 0.0182
Schistosoma mansoni hypothetical protein 0.0319 0.0805 0.0805
Echinococcus multilocularis serine protein kinase ATM 0.0734 0.1908 0.1907
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0056 0.0056
Brugia malayi intermediate filament protein 0.0028 0.0032 0.0032
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0022 0.0016 0.0016
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3021 0.7977 0.7977
Schistosoma mansoni neuropeptide f receptor 76f 0.0037 0.0056 0.0056
Echinococcus granulosus g-protein coupled receptor 0.0037 0.0056 0.0056
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0254 0.0634 0.0633
Onchocerca volvulus 0.0043 0.0074 0.0768
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0035 0.005 0.1778
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0056 0.0056
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0044 0.0044
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0028 0.0033 0.0032
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0037 0.0056 0.0056
Leishmania major heat shock protein 83-1 0.0028 0.0033 0.0032
Leishmania major phosphatidylinositol 3-kinase, putative 0.0275 0.0688 0.0687
Echinococcus multilocularis dro:myosuppressin receptor 0.0037 0.0056 0.0056
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0451 0.1154 0.114
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0254 0.0634 0.0633
Trypanosoma cruzi Heat shock protein 83, putative 0.0028 0.0033 0.0017
Onchocerca volvulus 0.0037 0.0056 0.0516
Leishmania major heat shock protein 83-1 0.0028 0.0033 0.0032
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0028 0.0033 0.1081
Leishmania major 4-coumarate:coa ligase-like protein 0.011 0.025 0.025
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0116 0.0116
Mycobacterium ulcerans Type I modular polyketide synthase 0.0022 0.0017 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.0734 0.1908 0.1895
Echinococcus multilocularis 0.0254 0.0634 0.0633
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0037 0.0056 0.0056
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0028 0.0033 0.046
Onchocerca volvulus 0.0037 0.0056 0.0516
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0112 0.0255 0.0254
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0296 0.0743 0.0726
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0037 0.0056 0.0056
Brugia malayi beta-lactamase family protein 0.0043 0.0074 0.0073
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0032 0.0044 0.1538
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0254 0.0634 0.9193
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0254 0.0634 0.085
Schistosoma mansoni adenoreceptor 0.0037 0.0056 0.0056
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0023 0.002 0.002
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0254 0.0634 0.0619
Mycobacterium tuberculosis Possible two component sensor kinase 0.0028 0.0033 0.046
Echinococcus multilocularis neuropeptide FF receptor 2 0.0037 0.0056 0.0056
Schistosoma mansoni biogenic amine receptor 0.0037 0.0056 0.0056
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0037 0.0056 0.0056
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0316 0.0797 0.0783
Echinococcus granulosus peptide allatostatin:somatostatin 0.0037 0.0056 0.0056
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0275 0.0688 0.0687
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0022 0.0017 0.0017
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.3784 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0037 0.0056 0.0056
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0196 0.0479 0.0464
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0112 0.0255 0.0239
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0023 0.002 0.0027
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0033 0.0017
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0028 0.0033 0.0802
Trichomonas vaginalis glucosylceramidase, putative 0.0232 0.0574 0.0559
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0116 0.0116
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0112 0.0255 0.0239
Echinococcus granulosus voltage gated potassium channel 0.0034 0.0048 0.0048
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0112 0.0255 0.0239
Brugia malayi hypothetical protein 0.0037 0.0056 0.0056
Onchocerca volvulus 0.0037 0.0056 0.0516
Leishmania major acetyl-CoA synthetase, putative 0.0032 0.0044 0.0044
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0023 0.002 0.0027
Loa Loa (eye worm) phosphatidylinositol 3 0.1309 0.3432 0.3431
Brugia malayi ORL1-like opioid receptor 0.0037 0.0056 0.0056
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0023 0.002 0.002
Schistosoma mansoni sodium/chloride dependent transporter 0.0137 0.0323 0.0322
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0275 0.0688 0.0673
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0044 0.1538
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0137 0.0323 0.0322
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0032 0.0044 0.0028
Schistosoma mansoni amine GPCR 0.0037 0.0056 0.0056
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0023 0.002 0.002
Onchocerca volvulus 0.0037 0.0056 0.0516
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0074 0.0058
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0116 0.0156
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0023 0.002 0.0027
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0032 0.0044 0.0637
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0037 0.0056 0.0056
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0056 0.0056
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0023 0.0019 0.0019
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0137 0.0323 0.0322
Mycobacterium ulcerans DNA gyrase subunit B 0.0028 0.0033 0.1081
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0056 0.0056
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0024 0.0021 0.0242
Leishmania major heat shock protein 83-1 0.0028 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Schistosoma mansoni heat shock protein 0.0028 0.0033 0.0032
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.011 0.025 0.3896
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0275 0.0688 0.0687
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0387 0.0986 0.0972
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0028 0.0033 0.0017
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0734 0.1908 0.1895
Echinococcus multilocularis lamin 0.0028 0.0032 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.2063 0.5433 0.5426
Brugia malayi hypothetical protein 0.0143 0.0337 0.0337
Schistosoma mansoni lamin 0.0028 0.0032 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0734 0.1908 0.1895
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0032 0.0044 0.0044
Brugia malayi Calcitonin receptor-like protein seb-1 0.0146 0.0345 0.0344
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0028 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Treponema pallidum sodium- and chloride- dependent transporter 0.0137 0.0323 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0023 0.002 0.002
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0032 0.0044 0.0028
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.011 0.025 0.9834
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Brugia malayi follicle stimulating hormone receptor 0.0037 0.0056 0.0056
Mycobacterium tuberculosis Probable thioesterase TesA 0.0019 0.0007 0.0098
Loa Loa (eye worm) translation initiation factor 4E 0.0022 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0146 0.0345 0.0344
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0116 0.0116
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0028 0.0033 0.1081
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0387 0.0986 0.0972
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0044 0.0044
Loa Loa (eye worm) TYRA-2 protein 0.0037 0.0056 0.0056
Onchocerca volvulus 0.0071 0.0147 0.1817
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0019 0.0019
Brugia malayi Dopamine receptor protein 2 0.0037 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.011 0.025 0.025
Echinococcus multilocularis g-protein coupled receptor 0.0037 0.0056 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.1298 0.3402 0.3392
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0042 0.007 0.007
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0037 0.0056 0.0056
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.0056 0.0056
Echinococcus granulosus tachykinin peptides receptor 99D 0.0037 0.0056 0.0056
Brugia malayi neuropeptide F receptor 0.0037 0.0056 0.0056
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0451 0.1154 0.114
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.135 0.354 0.354
Leishmania major phosphatidylinositol kinase related protein, putative 0.0254 0.0634 0.0633
Mycobacterium ulcerans Type I modular polyketide synthase 0.0022 0.0017 0.0464
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0037 0.0056 0.0056
Toxoplasma gondii target of rapamycin (TOR), putative 0.2825 0.7456 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0695 1
Giardia lamblia Pms1-like protein 0.0028 0.0033 0.0014
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0112 0.0255 0.7758
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0028 0.0033 0.0472
Loa Loa (eye worm) hypothetical protein 0.0043 0.0074 0.0073
Schistosoma mansoni opsin-like receptor 0.0037 0.0056 0.0056
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0037 0.0056 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.1017 0.2657 0.2645
Onchocerca volvulus 0.0036 0.0054 0.0485
Onchocerca volvulus 0.0037 0.0056 0.0516
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0023 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Brugia malayi RE15519p 0.0037 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0504 0.1296 0.1296
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0254 0.0634 0.0619
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0746 0.1937 0.1924
Chlamydia trachomatis DNA gyrase subunit B 0.0028 0.0033 0.0802
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0818 0.2128 0.2854
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0112 0.0255 0.0254
Loa Loa (eye worm) hypothetical protein 0.0034 0.0048 0.0048
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0056 0.0056
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.3784 1 1
Mycobacterium ulcerans thioesterase 0.0019 0.0007 0.0068
Echinococcus granulosus heat shock protein 0.0028 0.0033 0.0032
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0028 0.0033 0.0017
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0081 0.008
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0254 0.0634 0.0633
Trichomonas vaginalis PIKK family atypical protein kinase 0.2538 0.6695 0.669
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0032 0.0044 0.0044
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0022 0.0016 0.0016
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0451 0.1154 0.1154
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0451 0.1154 0.114
Brugia malayi prolyl oligopeptidase family protein 0.0178 0.043 0.043
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.0056 0.0056
Echinococcus granulosus neuropeptide receptor A26 0.0037 0.0056 0.0056
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0112 0.0255 0.0239
Echinococcus multilocularis geminin 0.0319 0.0805 0.0805
Loa Loa (eye worm) hypothetical protein 0.0734 0.1908 0.1907
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0112 0.0255 0.0254
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0035 0.005 0.005
Toxoplasma gondii heat shock protein 90, putative 0.0028 0.0033 0.0044
Schistosoma mansoni amine GPCR 0.0037 0.0056 0.0056
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0254 0.0634 0.0619
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0033 0.0046 0.066
Schistosoma mansoni immunophilin 0.0112 0.0255 0.0254
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0254 0.0634 0.0619
Loa Loa (eye worm) hypothetical protein 0.0043 0.0074 0.0073
Schistosoma mansoni DNA topoisomerase II 0.0028 0.0033 0.0032
Schistosoma mansoni transcription factor LCR-F1 0.0067 0.0135 0.0135
Loa Loa (eye worm) phosphatidylinositol 3 0.0587 0.1517 0.1517
Schistosoma mansoni immunophilin 0.0096 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0082 0.0177 0.0176
Echinococcus multilocularis serotonin receptor 0.0037 0.0056 0.0056
Leishmania major hypothetical protein, conserved 0.0028 0.0033 0.0032
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0081 0.008
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0176 0.0426 0.0571
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0037 0.0056 0.0056
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0022 0.0016 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0056 0.0056
Echinococcus granulosus neuropeptide receptor 0.0037 0.0056 0.0056
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0112 0.0255 0.0254
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0275 0.0688 0.0687
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0037 0.0056 0.0056
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0037 0.0056 0.0056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0056 0.0056
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0074 0.0058
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0254 0.0634 0.0633
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0178 0.043 0.5878
Trypanosoma brucei heat shock protein, putative 0.0028 0.0033 0.0017
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0734 0.1908 0.1895
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0056 0.0056
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0056 0.0056
Loa Loa (eye worm) FKBP5 protein 0.0112 0.0255 0.0254
Loa Loa (eye worm) hypothetical protein 0.0082 0.0177 0.0176
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0096 0.0214 0.0214
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0019 0.0018
Leishmania major peptidylprolyl isomerase-like protein 0.0112 0.0255 0.0254
Brugia malayi hypothetical protein 0.0037 0.0056 0.0056
Mycobacterium ulcerans hypothetical protein 0.011 0.025 0.9834
Onchocerca volvulus 0.0254 0.0634 0.8799
Echinococcus multilocularis somatostatin receptor 0.0037 0.0056 0.0056
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.0056 0.0056
Brugia malayi larval opioid receptor 0.0037 0.0056 0.0056
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0037 0.0056 0.0056
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0275 0.0688 0.0673
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0275 0.0688 0.0673
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0044 0.1538
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0024 0.0021 0.0611
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0519 0.1335 0.1335
Trichomonas vaginalis PIKK family atypical protein kinase 0.2825 0.7456 0.7452
Trichomonas vaginalis receptor histidine kinase, putative 0.0028 0.0033 0.0017
Trypanosoma brucei heat shock protein, putative 0.0028 0.0033 0.0017
Echinococcus multilocularis sodium and chloride dependent glycine 0.0023 0.002 0.002
Trypanosoma cruzi heat shock protein 90, putative 0.0028 0.0033 0.0017
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Echinococcus multilocularis G protein coupled receptor 139 0.0037 0.0056 0.0056
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0023 0.002 0.002
Leishmania major eukaryotic translation initiation factor-like protein 0.0022 0.0016 0.0016
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0028 0.0033 1
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0717 0.0703
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0028 0.0033 0.0465
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0084 0.0182 0.0182
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.005 0.1778
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0116 0.0116
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0176 0.0426 0.0411
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0056 0.0056
Entamoeba histolytica heat shock protein 90, putative 0.0028 0.0033 0.0017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0044 0.0624
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.011 0.025 0.3594
Entamoeba histolytica hypothetical protein 0.0254 0.0634 0.0619
Brugia malayi P38 map kinase family protein 2 0.0112 0.0255 0.0255
Entamoeba histolytica protein kinase rad3, putative 0.0734 0.1908 0.1895
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0504 0.1296 0.1282
Trichomonas vaginalis conserved hypothetical protein 0.048 0.1232 0.1218
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.0021 0.0611
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0056 0.0056
Trypanosoma brucei heat shock protein, putative 0.0028 0.0033 0.0017
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0037 0.0056 0.0056
Schistosoma mansoni opsin-like receptor 0.0037 0.0056 0.0056
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0275 0.0688 0.0687
Trichomonas vaginalis PIKK family atypical protein kinase 0.2256 0.5946 0.5939
Brugia malayi AMP-binding enzyme family protein 0.011 0.025 0.025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0084 0.0182 0.0182
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0048 0.0048
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0037 0.0056 0.0056
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0112 0.0255 0.0239
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0082 0.0177 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.0023 0.0019 0.0019
Loa Loa (eye worm) MH2 domain-containing protein 0.0225 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0143 0.0337 0.0337
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0254 0.0634 0.0619
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0451 0.1154 0.114
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0056 0.0056
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0116 0.1663
Brugia malayi Serotonin receptor 0.0037 0.0056 0.0056
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1298 0.3402 0.3392
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.135 0.354 0.354
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0032 0.0044 0.0028
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0032 0.0044 0.0028
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0734 0.1908 0.1907
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0096 0.0214 0.0214
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.3784 1 1
Schistosoma mansoni opsin-like receptor 0.0037 0.0056 0.0056
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0028 0.0033 0.0465
Schistosoma mansoni hypothetical protein 0.0037 0.0056 0.0056
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0734 0.1908 0.1907
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0112 0.0255 0.0255
Schistosoma mansoni endoplasmin 0.0028 0.0033 0.0032
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0254 0.0634 0.0619
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0056 0.0056
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2272 0.5989 0.5989
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0035 0.005 0.071
Mycobacterium leprae Probable lipase LipE 0.0043 0.0074 0.1081
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0037 0.0056 0.0056
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0035 0.005 0.1778
Trypanosoma brucei Heat shock protein 83, putative 0.0028 0.0033 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0054 0.0054
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0734 0.1908 0.1895
Leishmania major heat shock protein 83-1 0.0028 0.0033 0.0032
Entamoeba histolytica heat shock protein 90, putative 0.0028 0.0033 0.0017
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0178 0.0431 0.0431
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0074 0.105
Onchocerca volvulus 0.0037 0.0056 0.0516
Brugia malayi beta-lactamase 0.0043 0.0074 0.0073
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0074 0.105
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0028 0.0033 0.0017
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0022 0.0017 0.0464
Brugia malayi neuropeptide F receptor 0.0037 0.0056 0.0056
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.006 0.0117 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.2825 0.7456 0.7452
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Trichomonas vaginalis glucosylceramidase, putative 0.0152 0.0362 0.0347
Trichomonas vaginalis glucosylceramidase, putative 0.0152 0.0362 0.0347
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0019 0.0018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0254 0.0634 0.0633
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0028 0.0033 0.046
Echinococcus granulosus neuropeptide FF receptor 2 0.0037 0.0056 0.0056
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0254 0.0634 0.9193
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0056 0.0056
Mycobacterium ulcerans acyl-CoA synthetase 0.011 0.025 0.9834
Leishmania major eukaryotic translation initiation factor-like 0.0022 0.0016 0.0016
Plasmodium vivax endoplasmin, putative 0.0028 0.0033 0.0211
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0056 0.0056
Schistosoma mansoni alpha-1 adrenergic receptor 0.0037 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Echinococcus multilocularis serotonin receptor 0.0037 0.0056 0.0056
Onchocerca volvulus Fatty acid synthase homolog 0.004 0.0065 0.0639
Onchocerca volvulus 0.0037 0.0056 0.0516
Entamoeba histolytica hypothetical protein 0.0067 0.0135 0.0119
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.011 0.025 0.3594
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0109 0.0247 0.0232
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.3784 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0034 0.0048 0.0048
Schistosoma mansoni voltage-gated potassium channel 0.0127 0.0296 0.0296
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0035 0.005 0.1778
Loa Loa (eye worm) TOPoisomerase family member 0.0028 0.0033 0.0032
Schistosoma mansoni 60S ribosomal protein L21 0.0018 0.0007 0.0007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0074 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0054 0.0054
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0379 0.0965 0.0965
Schistosoma mansoni hypothetical protein 0.0046 0.0081 0.008
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0056 0.0056
Leishmania major heat shock protein 83-1 0.0028 0.0033 0.0032
Schistosoma mansoni hypothetical protein 0.0037 0.0056 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.3784 1 1
Trypanosoma cruzi heat shock protein 90, putative 0.0028 0.0033 0.0017
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0338 0.0856 0.0841
Loa Loa (eye worm) hypothetical protein 0.0563 0.1453 0.1453
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0056 0.0056
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0084 0.0182 0.0182
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0028 0.0033 0.0017
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0019 0.0007 0.0027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0078 0.0165 0.236
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0316 0.0797 0.0783
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0254 0.0634 0.0633
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0024 0.0021 0.0292
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0204 0.05 0.0671
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0275 0.0688 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0023 0.002 0.002
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0022 0.0015 0.0213
Loa Loa (eye worm) hypothetical protein 0.0043 0.0074 0.0073
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0028 0.0033 0.046
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.0384 0.0368
Leishmania major heat shock protein 83-1 0.0028 0.0033 0.0032
Trypanosoma cruzi DNA topoisomerase II, putative 0.0028 0.0033 0.0017
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0074 0.0073
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0074 0.0058
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0451 0.1154 0.114
Trichomonas vaginalis PIKK family atypical protein kinase 0.3018 0.7969 0.7966
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.006 0.0117 0.0101
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0028 0.0033 0.0032
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0028 0.0033 0.0017
Leishmania major heat shock protein 83-1 0.0028 0.0033 0.0032
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.3784 1 1
Schistosoma mansoni amine GPCR 0.0037 0.0056 0.0056
Echinococcus granulosus hyperpolarization activated cyclic 0.0023 0.0019 0.0019
Giardia lamblia Heat shock protein HSP 90-alpha 0.0028 0.0033 0.0014
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0032 0.0044 0.0624
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0379 0.0965 0.0965
Trichomonas vaginalis PIKK family atypical protein kinase 0.1309 0.3432 0.3421
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0028 0.0033 0.0032
Onchocerca volvulus 0.0137 0.0323 0.4339
Trichomonas vaginalis PIKK family atypical protein kinase 0.3018 0.7969 0.7966
Leishmania major hypothetical protein, unknown function 0.0254 0.0634 0.0633
Echinococcus granulosus sodium and chloride dependent glycine 0.0023 0.002 0.002
Trichomonas vaginalis antibiotic synthetase, putative 0.0032 0.0044 0.0028
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0022 0.0015 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.048 0.1232 0.1218
Trypanosoma brucei heat shock protein, putative 0.0028 0.0033 0.0017
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0056 0.0056
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0037 0.0056 0.0056
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0081 0.008
Brugia malayi G protein-coupled receptor F59B2.13 0.0037 0.0056 0.0056
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0044 0.1538
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0112 0.0255 0.024
Trichomonas vaginalis antibiotic synthetase, putative 0.0032 0.0044 0.0028
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0018 0.0007 0.0084
Leishmania major heat shock protein 83-1 0.0028 0.0033 0.0032
Trichomonas vaginalis glucosylceramidase, putative 0.0152 0.0362 0.0347
Brugia malayi hypothetical protein 0.0046 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Brugia malayi hypothetical protein 0.0037 0.0056 0.0056
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0112 0.0255 0.0239
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.3784 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0254 0.0634 0.0619
Mycobacterium ulcerans putative regultory protein 0.0028 0.0033 0.1081
Onchocerca volvulus 0.0037 0.0056 0.0516
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0112 0.0255 0.0239
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0033 0.0211
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0074 0.0073
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.3784 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Trypanosoma brucei heat shock protein, putative 0.0028 0.0033 0.0017
Loa Loa (eye worm) hypothetical protein 0.0023 0.0019 0.0019
Onchocerca volvulus 0.0037 0.0056 0.0516
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Loa Loa (eye worm) phosphatidylinositol 3 0.0062 0.0122 0.0122
Echinococcus granulosus serotonin transporter 0.0137 0.0323 0.0322
Echinococcus granulosus heat shock protein 90 0.0028 0.0033 0.0032
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0232 0.0574 0.0573
Toxoplasma gondii hypothetical protein 0.0023 0.002 0.0027
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0023 0.002 0.002
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0054 0.0072
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0028 0.0033 0.1081
Schistosoma mansoni amine GPCR 0.0037 0.0056 0.0056
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0112 0.0255 0.0239
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0254 0.0634 0.0633
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0074 0.2729
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0056 0.0056
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0019 0.0019
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0033 0.0046 0.066
Loa Loa (eye worm) endoplasmin 0.0028 0.0033 0.0032
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0028 0.0033 0.0017
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0023 0.002 0.002
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0056 0.0056
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0275 0.0688 0.0673
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Mycobacterium tuberculosis Conserved protein 0.0043 0.0074 0.105
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0254 0.0634 0.085
Schistosoma mansoni hypothetical protein 0.01 0.0222 0.0222
Brugia malayi GnHR receptor homolog 0.0037 0.0056 0.0056
Mycobacterium ulcerans thioesterase TesA 0.0019 0.0007 0.0068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0056 0.0056
Mycobacterium ulcerans acyl-CoA synthetase 0.011 0.025 0.9834
Brugia malayi G-protein coupled receptor 0.0037 0.0056 0.0056
Echinococcus granulosus hyperpolarization activated cyclic 0.0023 0.0019 0.0019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0084 0.0182 0.0182
Schistosoma mansoni neuropeptide receptor 0.0037 0.0056 0.0056
Leishmania major heat shock protein 83-1 0.0028 0.0033 0.0032
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0044 0.1538
Mycobacterium ulcerans acyl-CoA synthetase 0.011 0.025 0.9834
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0056 0.0056
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0023 0.002 0.002
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0032 0.0044 0.1538
Toxoplasma gondii exonuclease III APE 0.0023 0.0019 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0056 0.0056
Onchocerca volvulus 0.0037 0.0056 0.0516
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.002
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0112 0.0255 0.0236
Loa Loa (eye worm) phosphatidylinositol 3 0.0254 0.0634 0.0633
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0254 0.0634 0.0619
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0028 0.0033 0.1081
Loa Loa (eye worm) hypothetical protein 0.0762 0.1981 0.1981
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.006 0.0117 0.0101
Loa Loa (eye worm) hypothetical protein 0.01 0.0222 0.0222
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0625 0.0625
Trypanosoma cruzi heat shock protein 85, putative 0.0028 0.0033 0.0017
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0032 0.0044 0.0609
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0056 0.0056
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0056 0.0056
Mycobacterium leprae Probable two component sensor kinase MprB 0.0028 0.0033 0.0428
Loa Loa (eye worm) prolyl oligopeptidase 0.0178 0.043 0.043
Mycobacterium ulcerans two component sensor kinase MprB 0.0028 0.0033 0.1081
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.002
Echinococcus multilocularis fk506 binding protein 0.0112 0.0255 0.0254
Echinococcus granulosus orexin receptor type 2 0.0037 0.0056 0.0056
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0074 0.105
Loa Loa (eye worm) hypothetical protein 0.0137 0.0323 0.0322
Brugia malayi Pre-SET motif family protein 0.0251 0.0625 0.0625
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0117 0.0268 0.0268
Trypanosoma brucei heat shock protein, putative 0.0028 0.0033 0.0017
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0112 0.0255 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0023 0.0019 0.0019
Plasmodium falciparum DNA gyrase subunit B 0.0028 0.0033 0.0472
Brugia malayi Dopamine receptor protein 1 0.0037 0.0056 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.2262 0.5962 0.5955
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0116 0.0116
Giardia lamblia Phosphatidylinositol 4-kinase 0.0254 0.0634 0.0616
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0117 0.0268 0.0268
Onchocerca volvulus 0.0028 0.0032 0.0174
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0563 0.1453 0.1453
Echinococcus multilocularis GPCR, family 2 0.0046 0.0081 0.008
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0074 0.105
Loa Loa (eye worm) hypothetical protein 0.0028 0.0032 0.0032
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0032 0.0044 0.1538
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0078 0.0165 0.236
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0034 0.0048 0.0048
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.011 0.025 0.9834
Echinococcus granulosus dro:myosuppressin receptor 0.0037 0.0056 0.0056
Echinococcus granulosus G protein coupled receptor 139 0.0037 0.0056 0.0056
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0056 0.0056
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0067 0.0135 0.0135
Trichomonas vaginalis DNA topoisomerase II, putative 0.0028 0.0033 0.0017
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1309 0.3432 0.3421
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0037 0.0056 0.0516
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0056 0.0056
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0056 0.0056
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0056 0.0056
Entamoeba histolytica hypothetical protein 0.0067 0.0135 0.0119
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0022 0.0017 0.0239
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0028 0.0033 0.0044
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Brugia malayi AMP-binding enzyme family protein 0.011 0.025 0.025
Entamoeba histolytica hypothetical protein 0.0409 0.1045 0.103
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0254 0.0634 0.0633
Mycobacterium ulcerans lipase LipD 0.0043 0.0074 0.2729
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0028 0.0033 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.2063 0.5433 0.5426
Entamoeba histolytica hypothetical protein 0.0254 0.0634 0.0619
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0519 0.1335 0.1335
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0028 0.0033 0.046
Brugia malayi Endoplasmin precursor 0.0028 0.0033 0.0032
Leishmania major fk506-binding protein 1-like protein 0.0112 0.0255 0.0254
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Plasmodium vivax heat shock protein 86, putative 0.0028 0.0033 0.0211
Loa Loa (eye worm) fatty acid synthase 0.0022 0.0016 0.0016
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0504 0.1296 0.1296
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0044 0.1538
Loa Loa (eye worm) hypothetical protein 0.0082 0.0177 0.0176
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0056 0.0056
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0146 0.0345 0.0344
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0054 0.0054
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0019 0.0003
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0176 0.0426 0.0426
Toxoplasma gondii FATC domain-containing protein 0.0734 0.1908 0.2558
Leishmania major mitochondrial DNA topoisomerase II 0.0028 0.0033 0.0032
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0056 0.0056
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0007 0.0007
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0023 0.002 0.002
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0024 0.0021 0.0292
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0037 0.0056 0.0056
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0074 0.0058
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0028 0.0033 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0232 0.0574 0.0559
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0023 0.002 0.002
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0035 0.005 0.0704
Leishmania major acetyl-CoA synthetase, putative 0.0032 0.0044 0.0044
Brugia malayi FAT domain containing protein 0.0563 0.1453 0.1453
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0082 0.0177 0.6865
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0023 0.0019 0.0019
Plasmodium vivax hypothetical protein, conserved 0.0023 0.002 0.0024
Mycobacterium tuberculosis Conserved protein 0.0043 0.0074 0.105
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0275 0.0688 0.0687
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0275 0.0688 0.0673
Brugia malayi putative neuropeptide receptor 0.0037 0.0056 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.3784 1 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0112 0.0255 0.0254
Trypanosoma brucei heat shock protein, putative 0.0028 0.0033 0.0017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0056 0.0056
Echinococcus granulosus mitogen activated protein kinase 11 0.0112 0.0255 0.0255
Echinococcus multilocularis Dipeptidyl peptidase 9 0.006 0.0117 0.0117
Schistosoma mansoni sodium/chloride dependent transporter 0.0024 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0254 0.0634 0.9214
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0074 0.0824
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0028 0.0033 0.046
Mycobacterium ulcerans polyketide synthase 0.0022 0.0017 0.0464
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.011 0.025 0.9834
Mycobacterium leprae Probable two-component sensor kinase 0.0028 0.0033 0.0428
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0023 0.0019 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0044 0.1538
Echinococcus multilocularis sodium and chloride dependent glycine 0.0023 0.002 0.002
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.3784 1 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0112 0.0255 0.0239
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0117 0.0268 0.0268
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0254 0.0634 0.9214
Mycobacterium tuberculosis Probable two component sensor kinase 0.0028 0.0033 0.046
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0451 0.1154 0.114
Entamoeba histolytica acyl-CoA synthetase, putative 0.011 0.025 0.0235
Mycobacterium ulcerans fatty-acid-CoA ligase 0.011 0.025 0.9834
Brugia malayi hypothetical protein 0.0067 0.0135 0.0135
Toxoplasma gondii propionate-CoA ligase 0.0032 0.0044 0.0059
Schistosoma mansoni neuropeptide receptor 0.0037 0.0056 0.0056
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0053 0.0099 0.0099
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3021 0.7977 0.7974
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0056 0.0056
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0116 0.4439
Echinococcus multilocularis heat shock protein 0.0028 0.0033 0.0032
Brugia malayi kinase, mitochondrial precursor 0.0504 0.1296 0.1296
Giardia lamblia Hypothetical protein 0.0254 0.0634 0.0616
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0074 0.0073
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0032 0.0044 0.0028
Loa Loa (eye worm) hypothetical protein 0.0082 0.0177 0.0176
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0048 0.0048
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0028 0.0033 0.046
Echinococcus granulosus neuropeptide receptor 0.0037 0.0056 0.0056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0056 0.0056
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0032 0.0044 0.1538
Loa Loa (eye worm) serotonin transporter b 0.0137 0.0323 0.0322
Echinococcus multilocularis neuropeptide s receptor 0.0037 0.0056 0.0056
Schistosoma mansoni fkbp-rapamycin associated protein 0.0734 0.1908 0.1907
Brugia malayi Probable DNA topoisomerase II 0.0028 0.0033 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.1298 0.3402 0.3392
Brugia malayi hypothetical protein 0.0023 0.002 0.002
Echinococcus granulosus GPCR family 2 0.0046 0.0081 0.008
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0563 0.1453 0.1453
Loa Loa (eye worm) hypothetical protein 0.0137 0.0323 0.0322
Leishmania major DNA topoisomerase ii 0.0028 0.0033 0.0032
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0023 0.002 0.002
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0028 0.0033 0.046
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0044 0.0624
Leishmania major phosphatidylinositol 3-kinase, putative 0.1298 0.3402 0.3402
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0019 0.0257
Loa Loa (eye worm) solute carrier family 6 member 4 0.0137 0.0323 0.0322
Onchocerca volvulus 0.0286 0.0717 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.0056 0.0056
Onchocerca volvulus 0.0143 0.0337 0.455
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0078 0.0165 0.236
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.006 0.0117 0.0117
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0112 0.0255 0.0254
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0056 0.0056
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0023 0.0019 0.0019
Trichomonas vaginalis fk506-binding protein, putative 0.0112 0.0255 0.0239
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0275 0.0688 0.0673
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0023 0.002 0.002
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0074 0.1081
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0074 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.2455 0.6474 0.6469
Schistosoma mansoni lamin 0.0028 0.0032 0.0032
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0023 0.002 0.002
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.135 0.354 0.354
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0178 0.043 0.043
Trypanosoma cruzi heat shock protein 85, putative 0.0028 0.0033 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0084 0.0182 0.0182
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.3784 1 1
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.011 0.025 0.025
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0056 0.0056
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0053 0.0099 0.1418
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0178 0.043 0.043
Plasmodium falciparum transporter, putative 0.0023 0.002 0.029
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0019 0.0018
Mycobacterium ulcerans polyketide synthase Pks13 0.0033 0.0046 0.1638
Trichomonas vaginalis PIKK family atypical protein kinase 0.206 0.5425 0.5418
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0316 0.0797 0.0783
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0054 0.0054
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0275 0.0688 0.0687
Schistosoma mansoni hypothetical protein 0.0037 0.0056 0.0056
Leishmania major heat shock protein 83-1 0.0028 0.0033 0.0032
Onchocerca volvulus Neuropeptide F receptor homolog 0.0037 0.0056 0.0516
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0734 0.1908 0.1907
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0254 0.0634 0.9193
Echinococcus granulosus serine protein kinase ATM 0.0734 0.1908 0.1907
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0022 0.0016 0.0016
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0316 0.0797 0.0783
Mycobacterium leprae conserved hypothetical protein 0.0254 0.0634 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0023 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Plasmodium vivax DNA topoisomerase II, putative 0.0028 0.0033 0.0211
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0037 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0254 0.0634 0.0633
Schistosoma mansoni biogenic amine receptor 0.0037 0.0056 0.0056
Plasmodium vivax hypothetical protein, conserved 0.0254 0.0634 0.9193
Trypanosoma cruzi target of rapamycin kinase 3 0.3021 0.7977 0.7974
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0316 0.0797 0.0783
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0031
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0056 0.0056
Echinococcus multilocularis allatostatin A receptor 0.0037 0.0056 0.0056
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0056 0.0056
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0074 0.105
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0379 0.0965 0.0965
Trichomonas vaginalis PIKK family atypical protein kinase 0.0254 0.0634 0.0619
Schistosoma mansoni histamine h1 receptor 0.0037 0.0056 0.0056
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.135 0.354 0.354
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0074 0.105
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.3018 0.7969 0.7966
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.135 0.354 0.353
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0028 0.0033 0.1081
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0316 0.0797 0.0783
Trypanosoma cruzi heat shock protein 85, putative 0.0028 0.0033 0.0017
Brugia malayi putative neuropeptide receptor NPR1 0.0037 0.0056 0.0056
Echinococcus multilocularis orexin receptor type 2 0.0037 0.0056 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.2825 0.7456 0.7452
Onchocerca volvulus Glucosylceramidase homolog 0.0152 0.0362 0.4904
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0254 0.0634 0.085
Echinococcus granulosus 7TM GPCR rhodopsin 0.0037 0.0056 0.0056
Brugia malayi beta-lactamase family protein 0.0043 0.0074 0.0073
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0275 0.0688 0.0922
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0316 0.0797 0.0797
Onchocerca volvulus 0.0043 0.0074 0.0768
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0074 0.0058
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0084 0.0182 0.0182
Schistosoma mansoni sodium-dependent amino acid transporter 0.0023 0.002 0.002
Entamoeba histolytica hypothetical protein 0.0254 0.0634 0.0619
Echinococcus granulosus sodium and chloride dependent glycine 0.0023 0.002 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0152 0.0362 0.0347
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0254 0.0634 0.0633
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0176 0.0426 0.0411
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0037 0.0056 0.0056
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0019 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0078 0.0165 0.236
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0032 0.0044 0.0044
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0067 0.0135 0.0135
Trichomonas vaginalis glucosylceramidase, putative 0.0232 0.0574 0.0559
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0056 0.0056
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0022 0.0017 0.0239
Loa Loa (eye worm) hypothetical protein 0.0137 0.0323 0.0322
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0054 0.0054
Schistosoma mansoni growth hormone secretagogue receptor 0.0037 0.0056 0.0056
Brugia malayi Dopamine receptor 0.0037 0.0056 0.0056
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0032 0.0032
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0629 0.1627 0.1627
Echinococcus multilocularis heat shock protein 90 0.0028 0.0033 0.0032
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0033 0.0017
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0081 0.008
Schistosoma mansoni neuropeptide receptor 0.0037 0.0056 0.0056
Echinococcus granulosus alpha 1A adrenergic receptor 0.0037 0.0056 0.0056
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0028 0.0033 0.046
Plasmodium falciparum endoplasmin, putative 0.0028 0.0033 0.0472
Brugia malayi translation initiation factor 4E 0.0022 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.2825 0.7456 0.7452
Plasmodium falciparum amino acid transporter, putative 0.0023 0.002 0.029
Loa Loa (eye worm) hypothetical protein 0.0254 0.0634 0.0633
Loa Loa (eye worm) phosphatidylinositol 3 0.0254 0.0634 0.0633
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0023 0.002 0.002
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0022 0.0016 0.0016
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0734 0.1908 0.1907
Leishmania major 4-coumarate:coa ligase-like protein 0.011 0.025 0.025
Echinococcus multilocularis G-protein coupled receptor, putative 0.0037 0.0056 0.0056
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0023 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.3018 0.7969 0.7966
Schistosoma mansoni ap endonuclease 0.0023 0.0019 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0056 0.0056
Onchocerca volvulus 0.0053 0.0099 0.1134
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0028 0.0033 0.046
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0032 0.0044 0.0059
Echinococcus multilocularis mitogen activated protein kinase 14 0.0112 0.0255 0.0255
Echinococcus granulosus neuropeptide s receptor 0.0037 0.0056 0.0056
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0019 0.0018
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0037 0.0056 0.0056
Echinococcus multilocularis lamin dm0 0.0028 0.0032 0.0032
Schistosoma mansoni pyruvate dehydrogenase 0.0476 0.1221 0.1221
Echinococcus granulosus lamin dm0 0.0028 0.0032 0.0032
Brugia malayi Serotonin receptor 0.0037 0.0056 0.0056
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0023 0.0019 0.0019
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0019 0.0019
Brugia malayi hypothetical protein 0.0037 0.0056 0.0056
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0023 0.0019 0.0019
Schistosoma mansoni myosin xvIII 0.0037 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0046 0.0081 0.008

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0398 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 0.7943 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 1.0323 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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