Detailed information for compound 1678595

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 445.495 | Formula: C19H23N7O4S
  • H donors: 5 H acceptors: 6 LogP: -0.42 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1)NCCSC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N
  • InChi: 1S/C19H23N7O4S/c20-16-13-17(23-9-22-16)26(10-24-13)18-15(28)14(27)12(30-18)8-31-7-6-21-19(29)25-11-4-2-1-3-5-11/h1-5,9-10,12,14-15,18,27-28H,6-8H2,(H2,20,22,23)(H2,21,25,29)/t12-,14-,15-,18-/m1/s1
  • InChiKey: ZVEFVGBDFYZLDZ-SCFUHWHPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens DOT1-like histone H3K79 methyltransferase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus histone h3 methyltransferase Get druggable targets OG5_130680 All targets in OG5_130680
Schistosoma mansoni histone J3 methyltransferase Get druggable targets OG5_130680 All targets in OG5_130680
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific Get druggable targets OG5_130680 All targets in OG5_130680
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130680 All targets in OG5_130680
Schistosoma japonicum ko:K05302 histone-lysine N-methyltransferase [EC2.1.1.43], putative Get druggable targets OG5_130680 All targets in OG5_130680
Echinococcus multilocularis histone h3 methyltransferase Get druggable targets OG5_130680 All targets in OG5_130680
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0085 0.0301 0.4952
Trichomonas vaginalis chromobox protein, putative 0.0033 0.0091 0.0183
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.003 0.0077 0.018
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0027 0.0066 0.1078
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.0423 0.087
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0017 0.0023 0.0023
Trichomonas vaginalis set domain proteins, putative 0.1189 0.4852 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0018 0.0028 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0028 0.0467
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0018 0.0034
Schistosoma mansoni aldo-keto reductase 0.003 0.0077 0.0116
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0116 0.043 0.043
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0023 0.005 0.0072
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0026 0.0061 0.0997
Onchocerca volvulus 0.003 0.0077 0.0154
Echinococcus granulosus zinc finger protein 0.0071 0.0247 0.0375
Echinococcus granulosus aldo keto reductase family 1 member B4 0.003 0.0077 0.0116
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0067 0.0231 0.3794
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0023 0.0042
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0159 0.0609 0.1116
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0729 0.2958 1
Onchocerca volvulus 0.003 0.0077 0.0154
Echinococcus granulosus thioredoxin glutathione reductase 0.0098 0.0357 0.0543
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0023 0.0035
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.008
Trypanosoma cruzi importin beta-1 subunit, putative 0.0101 0.0371 0.61
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.0092 0.1965
Brugia malayi kap beta 3 protein 0.0024 0.0051 0.0119
Brugia malayi Calcitonin receptor-like protein seb-1 0.0312 0.124 0.2912
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0028 0.0467
Schistosoma mansoni hypothetical protein 0.0126 0.0472 0.0718
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0213 0.0831 0.1263
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.0092 0.1513
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0023 0.0042
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0067 0.0231 0.3794
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0201 0.078 0.1185
Brugia malayi hypothetical protein 0.0582 0.2352 0.5524
Trypanosoma cruzi trypanothione reductase, putative 0.0097 0.0354 0.5814
Toxoplasma gondii PHD-finger domain-containing protein 0.0012 0.0002 0.0021
Echinococcus multilocularis mixed lineage leukemia protein mll 0.003 0.0076 0.0076
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase NIMA-interacting 4, putative 0.0108 0.0397 0.6518
Plasmodium vivax thioredoxin reductase, putative 0.0097 0.0354 0.612
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0092 0.1513
Trichomonas vaginalis CMGC family protein kinase 0.0032 0.0085 0.0172
Brugia malayi hypothetical protein 0.0163 0.0625 0.1468
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.0092 0.1593
Echinococcus multilocularis translational activator gcn1 0.0024 0.0051 0.0051
Echinococcus granulosus Zinc finger DBF type 0.0012 0.0002 0.0003
Onchocerca volvulus 0.1189 0.4852 1
Echinococcus granulosus transportin 1 0.0024 0.0051 0.0077
Plasmodium falciparum SNF2 helicase, putative 0.0012 0.0002 0.0035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0211 0.0824 0.1695
Echinococcus granulosus histone lysine methyltransferase setb 0.0207 0.0805 0.1223
Toxoplasma gondii PHD-finger domain-containing protein 0.0012 0.0002 0.0021
Echinococcus multilocularis protein dispatched 1 0.0046 0.0141 0.0141
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.008 0.0175
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0023 0.0035
Brugia malayi Telomerase reverse transcriptase 0.0089 0.032 0.0751
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific 0.0155 0.0591 0.1389
Entamoeba histolytica acetyltransferase, GNAT family 0.0028 0.007 0.0544
Schistosoma mansoni hypothetical protein 0.0038 0.0112 0.017
Schistosoma mansoni tsg101-related 0.0136 0.0513 0.0779
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0044 0.0135 0.1722
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0149 0.0567 0.0863
Echinococcus granulosus lysine specific demethylase 5B 0.0012 0.0002 0.0003
Toxoplasma gondii thioredoxin reductase 0.0097 0.0354 0.4528
Toxoplasma gondii peptidylprolyl isomerase 0.0075 0.0264 0.3374
Schistosoma mansoni ran 0.0079 0.0279 0.0424
Loa Loa (eye worm) heterochromatin protein 1 0.0204 0.0792 0.1451
Trichomonas vaginalis hypothetical protein 0.0012 0.0002 0.0001
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.0092 0.1513
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.003 0.0077 0.0122
Brugia malayi hypothetical protein 0.0989 0.4027 0.9458
Brugia malayi RNA, U transporter 1 0.0356 0.1419 0.3333
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0185 0.0716 0.1088
Schistosoma mansoni hypothetical protein 0.0912 0.3709 0.5638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0101 0.037 0.037
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0094 0.0342 0.0804
Brugia malayi MAP kinase sur-1 0.0032 0.0085 0.02
Brugia malayi jmjC domain containing protein 0.0054 0.0177 0.0415
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0078 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0134 0.0505 0.0925
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0114 0.0423 0.087
Entamoeba histolytica hypothetical protein 0.0027 0.0066 0.0494
Loa Loa (eye worm) hypothetical protein 0.0033 0.0091 0.0166
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0033 0.0091 0.0091
Echinococcus granulosus lysine specific demethylase 5A 0.0054 0.0177 0.0269
Mycobacterium tuberculosis Probable dehydrogenase 0.0222 0.0867 0.2863
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0075 0.0264 0.2979
Echinococcus granulosus neuropeptide receptor A26 0.029 0.1148 0.1745
Echinococcus multilocularis GPCR, family 2 0.0099 0.036 0.036
Toxoplasma gondii LsmAD domain-containing protein 0.0038 0.0108 0.1381
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0027 0.0066 0.1078
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0028 0.0467
Onchocerca volvulus 0.003 0.0077 0.0154
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0067 0.0231 0.0351
Brugia malayi steroid hormone receptor 0.0017 0.0023 0.0053
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.008 0.1311
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0073 0.0256 0.2858
Echinococcus multilocularis Polycystic kidney disease protein 0.0043 0.0129 0.0129
Brugia malayi chromobox protein homolog 3 0.0114 0.0423 0.0994
Echinococcus multilocularis lipoxygenase domain containing protein 0.0043 0.0129 0.0129
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0082 0.029 0.029
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0364 0.1451 0.2206
Loa Loa (eye worm) hypothetical protein 0.0603 0.2437 0.4466
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.017 0.0652 0.1532
Echinococcus multilocularis aldo keto reductase 0.003 0.0077 0.0077
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0163 0.0625 0.0625
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0035
Schistosoma mansoni ran 0.0079 0.0279 0.0424
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0077 0.0271 0.0637
Trypanosoma brucei aldo-keto reductase, putative 0.003 0.0077 0.1258
Echinococcus multilocularis thioredoxin glutathione reductase 0.0098 0.0357 0.0357
Echinococcus multilocularis zinc finger protein 0.0071 0.0247 0.0247
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.002 0.0034 0.0564
Schistosoma mansoni hypothetical protein 0.0012 0.0002 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0066 0.0132
Trypanosoma brucei Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.002 0.0034 0.0564
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.0092 0.1179
Loa Loa (eye worm) hypothetical protein 0.0124 0.0463 0.0848
Treponema pallidum NADH oxidase 0.0034 0.0092 0.0412
Trypanosoma brucei unspecified product 0.0018 0.0028 0.0467
Entamoeba histolytica hypothetical protein 0.0027 0.0066 0.0494
Brugia malayi acetyltransferase, GNAT family protein 0.0112 0.0416 0.0978
Trypanosoma cruzi PAB1-binding protein , putative 0.0038 0.0108 0.1774
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0045 0.0089
Onchocerca volvulus 0.0035 0.0096 0.0194
Onchocerca volvulus 0.0033 0.0091 0.0183
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.003 0.0077 0.0077
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0023 0.005 0.0639
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.0092 0.1593
Onchocerca volvulus 0.0089 0.0322 0.066
Brugia malayi PHD-finger family protein 0.0012 0.0002 0.0004
Brugia malayi Associated with TFs and helicases family protein 0.0033 0.0091 0.0213
Trypanosoma brucei unspecified product 0.0013 0.0005 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0028 0.0467
Onchocerca volvulus 0.0149 0.0567 0.1167
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0729 0.2958 1
Onchocerca volvulus 0.0185 0.0716 0.1472
Schistosoma mansoni zinc finger protein 0.0049 0.0156 0.0238
Brugia malayi PHD-finger family protein 0.0012 0.0002 0.0004
Loa Loa (eye worm) thioredoxin reductase 0.0097 0.0354 0.0649
Schistosoma mansoni patched 1 0.004 0.0118 0.0179
Echinococcus granulosus expressed protein 0.0077 0.0271 0.0412
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0067 0.0231 0.3794
Trichomonas vaginalis aldo-keto reductase, putative 0.003 0.0077 0.0154
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0033 0.0091 0.1496
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0051 0.0164 0.2697
Schistosoma mansoni kinase 0.0081 0.0287 0.0436
Trypanosoma brucei Histone methylation protein DOT1, putative 0.002 0.0034 0.0564
Loa Loa (eye worm) hypothetical protein 0.0033 0.0091 0.0166
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0051 0.0164 0.21
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0023 0.0035
Echinococcus granulosus RUN 0.0043 0.0129 0.0197
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0112 0.0416 0.0633
Echinococcus granulosus importin 5 0.0024 0.0051 0.0077
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0023 0.0023
Trypanosoma cruzi polo-like protein kinase, putative 0.0159 0.0609 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0023 0.0035
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.012 0.0446 0.0917
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0152 0.0578 0.0879
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0073 0.0256 0.0524
Loa Loa (eye worm) CHromoDomain protein family member 0.0045 0.0139 0.0255
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0027 0.0066 0.1078
Brugia malayi hypothetical protein 0.0033 0.0091 0.0213
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0112 0.0416 0.0416
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0026 0.0061 0.0432
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0003
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0043 0.0128 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0286 0.0587
Schistosoma mansoni PHD zinc finger protein XAP135-related 0.0012 0.0002 0.0003
Schistosoma mansoni inositol monophosphatase 0.0051 0.0164 0.025
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.008 0.138
Trichomonas vaginalis aldo/keto reductase, putative 0.003 0.0077 0.0154
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0073 0.0256 0.4421
Entamoeba histolytica aldose reductase, putative 0.003 0.0077 0.0631
Loa Loa (eye worm) oxidoreductase 0.003 0.0077 0.014
Brugia malayi Muscleblind-like protein 0.0603 0.2437 0.5723
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0101 0.0371 0.0762
Echinococcus multilocularis Smad4 0.0016 0.0018 0.0018
Echinococcus multilocularis sterol regulatory element binding protein 0.004 0.0118 0.0118
Echinococcus multilocularis Kelch repeat type 1 0.0159 0.0609 0.0609
Entamoeba histolytica hypothetical protein 0.0033 0.0091 0.0807
Schistosoma mansoni hypothetical protein 0.0033 0.0091 0.0138
Echinococcus granulosus histone acetyltransferase KAT2B 0.0038 0.0112 0.017
Onchocerca volvulus 0.0098 0.0356 0.0731
Echinococcus granulosus Chromobox protein 3 0.0033 0.0091 0.0138
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0097 0.0354 0.1111
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0028 0.0467
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.008 0.1311
Brugia malayi intermediate filament protein 0.0035 0.0096 0.0224
Echinococcus granulosus sterol regulatory element binding protein 0.004 0.0118 0.0179
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0039 0.0114 0.0232
Schistosoma mansoni pol-related 0.003 0.0077 0.0116
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.003 0.0077 0.0077
Toxoplasma gondii aldose reductase, putative 0.003 0.0077 0.098
Echinococcus multilocularis smad 0.0016 0.0018 0.0018
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0211 0.0824 1
Loa Loa (eye worm) mbt repeat family protein 0.0149 0.0567 0.104
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0018 0.0028
Echinococcus multilocularis chromobox protein 1 0.0204 0.0792 0.0792
Mycobacterium ulcerans aldehyde dehydrogenase 0.0101 0.037 0.1167
Echinococcus granulosus chromobox protein 2 0.0033 0.0091 0.0138
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0036 0.0101 0.0101
Trypanosoma cruzi polo-like protein kinase, putative 0.0159 0.0609 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0023 0.0035
Entamoeba histolytica hypothetical protein 0.0033 0.0091 0.0807
Echinococcus granulosus expressed conserved protein 0.0087 0.0313 0.0476
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0023 0.0042
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.008 0.1311
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0042
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0023 0.0023
Schistosoma mansoni cpg binding protein 0.011 0.0405 0.0615
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0042
Schistosoma mansoni transcription factor LCR-F1 0.0126 0.0472 0.0718
Echinococcus granulosus aldo keto reductase family 1 member B4 0.003 0.0077 0.0116
Echinococcus granulosus Niemann Pick C1 protein 0.0093 0.0336 0.0511
Schistosoma mansoni lipoxygenase 0.0165 0.0633 0.0963
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0028 0.0467
Toxoplasma gondii aldehyde dehydrogenase 0.0101 0.037 0.4738
Schistosoma mansoni inositol monophosphatase 0.0051 0.0164 0.025
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0032 0.0085 0.1087
Brugia malayi PHD-finger family protein 0.0012 0.0002 0.0004
Echinococcus granulosus aldo keto reductase 0.003 0.0077 0.0116
Toxoplasma gondii HEAT repeat-containing protein 0.0125 0.0469 0.5998
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0075 0.0264 0.4333
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0045 0.0089
Brugia malayi latrophilin 2 splice variant baaae 0.0213 0.0833 0.1956
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0729 0.2958 1
Schistosoma mansoni ap endonuclease 0.0026 0.0061 0.0092
Echinococcus granulosus GTP binding nuclear protein Ran 0.0079 0.0279 0.0424
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0099 0.036 0.0548
Schistosoma mansoni hypothetical protein 0.0213 0.0833 0.1266
Loa Loa (eye worm) oxidoreductase 0.003 0.0077 0.014
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0079 0.0279 0.0279
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0032 0.0085 0.1396
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0075 0.0264 0.4333
Trypanosoma brucei PAB1-binding protein , putative 0.0038 0.0108 0.1774
Echinococcus granulosus SAM and MBT domain containing protein 0.0149 0.0567 0.0863
Schistosoma mansoni hypothetical protein 0.0038 0.0112 0.017
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0023 0.0035
Brugia malayi Pre-SET motif family protein 0.0152 0.0578 0.1358
Plasmodium falciparum ataxin-2 like protein, putative 0.0038 0.0108 0.2303
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0018 0.0028
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0018 0.0034
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0035
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0092 0.1513
Schistosoma mansoni hypothetical protein 0.0049 0.0156 0.0238
Brugia malayi Troponin T 0.0039 0.0114 0.0269
Trichomonas vaginalis CAMK family protein kinase 0.0159 0.0609 0.1252
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0066 0.1078
Loa Loa (eye worm) importin-beta domain-containing protein 0.0024 0.0051 0.0093
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0038 0.0112 0.1931
Echinococcus multilocularis TAF3 RNA polymerase II, TATA box binding protein 0.0012 0.0002 0.0002
Trichomonas vaginalis aldo-keto reductase, putative 0.003 0.0077 0.0154
Echinococcus multilocularis mitogen activated protein kinase 3 0.0032 0.0085 0.0085
Plasmodium falciparum zinc finger protein, putative 0.0018 0.0026 0.0559
Echinococcus granulosus hypothetical protein 0.003 0.0077 0.0116
Trichomonas vaginalis importin beta-1, putative 0.0101 0.0371 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0045 0.0089
Echinococcus granulosus snurportin 1 0.1336 0.5457 0.8295
Brugia malayi hypothetical protein 0.0043 0.0129 0.0304
Trypanosoma cruzi PAB1-binding protein , putative 0.0038 0.0108 0.1774
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0051 0.0164 0.0335
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0073 0.0256 0.0524
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0017 0.0023 0.0043
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0018 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0012 0.0002 0.0003
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0094 0.0342 0.052
Schistosoma mansoni hypothetical protein 0.0099 0.036 0.0548
Schistosoma mansoni lamin 0.0035 0.0096 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0091 0.0183
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0026 0.0061 0.1294
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0045 0.0089
Plasmodium falciparum thioredoxin reductase 0.0097 0.0354 0.7549
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0045 0.0089
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.003 0.0077 0.0077
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0026 0.0061 0.0061
Brugia malayi PHD-finger family protein 0.0012 0.0002 0.0004
Brugia malayi Importin beta-1 subunit 0.0125 0.0469 0.1101
Trichomonas vaginalis chromobox protein, putative 0.0033 0.0091 0.0183
Schistosoma mansoni smad1 5 8 and 0.0016 0.0018 0.0028
Trichomonas vaginalis CAMK family protein kinase 0.0079 0.0278 0.0571
Loa Loa (eye worm) troponin 0.0039 0.0114 0.021
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0033 0.0091 0.1496
Echinococcus multilocularis importin subunit beta 1 0.0125 0.0469 0.0469
Leishmania major telomerase reverse transcriptase, putative 0.0033 0.0091 0.1496
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.003 0.0077 0.018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0091 0.0183
Loa Loa (eye worm) hypothetical protein 0.0039 0.0114 0.021
Echinococcus multilocularis chromobox protein 1 0.0204 0.0792 0.0792
Schistosoma mansoni Smad4 0.0016 0.0018 0.0028
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.0092 0.0092
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0092 0.1513
Onchocerca volvulus 0.0119 0.0443 0.0909
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0045 0.0089
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0033 0.0091 0.0138
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0126 0.0472 0.0472
Schistosoma mansoni troponin I 0.0066 0.0225 0.0342
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.0609 0.0925
Brugia malayi Intermediate filament tail domain containing protein 0.0035 0.0096 0.0224
Brugia malayi cytoplasmic intermediate filament protein 0.0018 0.0029 0.0069
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0003
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0018 0.0028 0.0467
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0055 0.0182 0.0372
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0073 0.0256 0.3271
Loa Loa (eye worm) hypothetical protein 0.0887 0.3608 0.6612
Loa Loa (eye worm) kap beta 3 protein 0.0024 0.0051 0.0093
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0023 0.0035
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0034 0.0092 0.0218
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0126 0.0472 0.0718
Echinococcus multilocularis Niemann Pick C1 protein 0.0133 0.0501 0.0501
Toxoplasma gondii AP2 domain transcription factor AP2VIIa-7 0.0012 0.0002 0.0021
Loa Loa (eye worm) helicase 0.0033 0.0091 0.0166
Echinococcus multilocularis mitogen activated protein kinase 0.0032 0.0085 0.0085
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0067 0.0231 0.0423
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0005 0.0084
Loa Loa (eye worm) hypothetical protein 0.0033 0.0091 0.0166
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.003 0.0077 0.0077
Trichomonas vaginalis inositol monophosphatase, putative 0.0051 0.0164 0.0335
Entamoeba histolytica hypothetical protein 0.0126 0.0472 0.5591
Loa Loa (eye worm) hypothetical protein 0.0887 0.3608 0.6612
Echinococcus granulosus PHD finger protein 14 0.0012 0.0002 0.0003
Echinococcus granulosus mitogen activated protein kinase 0.0032 0.0085 0.0129
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0033 0.0091 0.1159
Echinococcus multilocularis peptidyl prolyl cis trans isomerase 0.0108 0.0397 0.0397
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.0237
Schistosoma mansoni hypothetical protein 0.0043 0.0129 0.0197
Plasmodium falciparum histone-lysine N-methyltransferase, H3 lysine-4 specific 0.0012 0.0002 0.0035
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0022 0.0045 0.0744
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0028 0.0467
Trichomonas vaginalis aldo-keto reductase, putative 0.003 0.0077 0.0154
Echinococcus granulosus methyl CpG binding domain protein 2 0.0055 0.018 0.0273
Plasmodium falciparum EELM2 domain-containing protein, putative 0.0012 0.0002 0.0035
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0076 0.0116
Schistosoma mansoni myst-related protein 0.0018 0.0026 0.004
Echinococcus granulosus lamin dm0 0.0035 0.0096 0.0145
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0027 0.0066 0.1078
Giardia lamblia Kinase, CMGC MAPK 0.0032 0.0085 0.0712
Trichomonas vaginalis CMGC family protein kinase 0.0032 0.0085 0.0172
Brugia malayi Isocitrate dehydrogenase 0.0031 0.008 0.0187
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0023 0.0035
Echinococcus granulosus kelch ECH associated protein 1 0.0159 0.0608 0.0923
Schistosoma mansoni hypothetical protein 0.0038 0.0112 0.017
Brugia malayi Inositol-1 0.0051 0.0164 0.0386
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0033 0.0091 0.0138
Giardia lamblia Kinase, PLK 0.0159 0.0609 0.7299
Schistosoma mansoni bromodomain containing protein 0.0022 0.0044 0.0066
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0017 0.0022 0.0022
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.003 0.0077 0.018
Loa Loa (eye worm) hypothetical protein 0.017 0.0652 0.1196
Onchocerca volvulus Huntingtin homolog 0.0251 0.0987 0.2032
Trichomonas vaginalis CMGC family protein kinase 0.0032 0.0085 0.0172
Plasmodium vivax SNF2 family N-terminal domain containing protein 0.0012 0.0002 0.0029
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0036 0.0101 0.0153
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0033 0.0091 0.1159
Echinococcus multilocularis polycomb protein SCMH1 0.0149 0.0567 0.0567
Leishmania major trypanothione reductase 0.0097 0.0354 0.5814
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0023 0.0053
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0032 0.0085 0.1396
Trichomonas vaginalis ran, putative 0.0079 0.0279 0.0571
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0055 0.0182 0.0372
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0207 0.0805 0.1223
Loa Loa (eye worm) hypothetical protein 0.0125 0.0469 0.0859
Entamoeba histolytica hypothetical protein 0.0126 0.0472 0.5591
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0032 0.0085 0.0156
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0023 0.005 0.0821
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0085 0.0129
Onchocerca volvulus 0.0017 0.0023 0.0043
Schistosoma mansoni chromobox protein 0.0033 0.0091 0.0138
Echinococcus granulosus smad 0.0016 0.0018 0.0028
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0222 0.0867 0.2863
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0079 0.0279 0.5946
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0045 0.0139 0.0211
Echinococcus multilocularis aldehyde reductase 0.0021 0.0041 0.0041
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.008 0.1021
Trichomonas vaginalis chromobox protein, putative 0.0123 0.0459 0.0943
Brugia malayi Heterochromatin protein 1 0.0204 0.0792 0.186
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0286 0.0587
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0027 0.0066 0.1078
Onchocerca volvulus 0.0043 0.0129 0.0263
Echinococcus multilocularis kelch ECH associated protein 1 0.0159 0.0608 0.0608
Toxoplasma gondii PHD-finger domain-containing protein 0.0012 0.0002 0.0021
Trichomonas vaginalis aldo/keto reductase, putative 0.003 0.0077 0.0154
Brugia malayi hypothetical protein 0.0039 0.0114 0.0269
Brugia malayi CXXC zinc finger family protein 0.0098 0.0356 0.0837
Giardia lamblia Aldose reductase 0.003 0.0077 0.0606
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0033 0.0091 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0023 0.0053
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0593 0.2395 0.3641
Schistosoma mansoni hypothetical protein 0.0099 0.036 0.0548
Schistosoma mansoni requim req/dpf2 0.0012 0.0002 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0211 0.0824 0.1695
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0023 0.0048 0.0073
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0207 0.0805 0.0805
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0042
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0092 0.1513
Onchocerca volvulus 0.0035 0.0096 0.0194
Loa Loa (eye worm) hypothetical protein 0.004 0.0118 0.0216
Schistosoma mansoni jumonji domain containing protein 0.0043 0.0128 0.0195
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.008 0.008
Brugia malayi M-phase phosphoprotein, mpp8 0.0033 0.0091 0.0213
Echinococcus multilocularis lamin 0.0035 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0089 0.0322 0.059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0023 0.0042
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0027 0.0066 0.1078
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0027 0.0066 0.1078
Echinococcus granulosus survival motor neuron protein 1 0.0582 0.2352 0.3576
Schistosoma mansoni lipoxygenase 0.0088 0.0316 0.0481
Brugia malayi PHD-finger family protein 0.0012 0.0002 0.0004
Entamoeba histolytica hypothetical protein 0.0101 0.0371 0.4328
Entamoeba histolytica Ran family GTPase 0.0079 0.0279 0.3167
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0033 0.0091 0.0213
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0024 0.0054 0.0889
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0122 0.0458 0.094
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0023 0.0053
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0201 0.078 0.078
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0123 0.0459 0.0943
Toxoplasma gondii RNA-directed DNA polymerase 0.0033 0.0091 0.1165
Toxoplasma gondii HEAT repeat-containing protein 0.0024 0.0051 0.065
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0034 0.0092 0.0218
Schistosoma mansoni hypothetical protein 0.0017 0.0023 0.0034
Brugia malayi hypothetical protein 0.0887 0.3608 0.8474
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0023 0.0023
Echinococcus multilocularis phd finger protein 10 0.0012 0.0002 0.0002
Leishmania major importin beta-1 subunit, putative 0.0101 0.0371 0.61
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0034 0.0051
Echinococcus multilocularis uro adherence factor A 0.0012 0.0002 0.0002
Echinococcus granulosus aldo keto reductase family 1 member B4 0.003 0.0077 0.0116
Onchocerca volvulus 0.003 0.0077 0.0154
Schistosoma mansoni cpg binding protein 0.0098 0.0356 0.0542
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.0028 0.0067
Loa Loa (eye worm) hypothetical protein 0.0049 0.0155 0.0284
Trichomonas vaginalis helicase, putative 0.0022 0.0045 0.0089
Loa Loa (eye worm) troponin T 0.0039 0.0114 0.021
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0051 0.0164 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0094 0.0342 0.0342
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.008 0.1021
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.003 0.0077 0.0077
Trypanosoma cruzi Ring finger domain/PHD-finger, putative 0.0012 0.0002 0.0027
Trypanosoma cruzi aldo-keto reductase 0.003 0.0077 0.1258
Brugia malayi MH1 domain containing protein 0.0016 0.0018 0.0043
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0079 0.0279 0.0655
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0159 0.0609 0.0925
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0051 0.0164 0.0335
Loa Loa (eye worm) bromodomain containing protein 0.006 0.0198 0.0364
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0027 0.0066 0.1078
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0033 0.0091 0.1932
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.008 0.008
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0018 0.0028 0.0052
Mycobacterium ulcerans aldehyde dehydrogenase 0.0101 0.037 0.1167
Schistosoma mansoni hypothetical protein 0.0099 0.036 0.0548
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0116 0.043 0.0654
Loa Loa (eye worm) hypothetical protein 0.0033 0.0091 0.0166
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.005 0.0821
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0023 0.0053
Onchocerca volvulus Serine\/threonine kinase homolog 0.0159 0.0609 0.1252
Echinococcus multilocularis dna polymerase eta 0.0018 0.0028 0.0028
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0046 0.0142 0.0347
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0364 0.1451 0.1451
Echinococcus multilocularis phd finger protein 12 0.0012 0.0002 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0023 0.0023
Trichomonas vaginalis hypothetical protein 0.0024 0.0051 0.0101
Trichomonas vaginalis aldo-keto reductase, putative 0.003 0.0077 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0023 0.0053
Echinococcus granulosus GPCR family 2 0.0099 0.036 0.0548
Brugia malayi MH1 domain containing protein 0.0016 0.0018 0.0043
Treponema pallidum fructose-bisphosphate aldolase 0.0211 0.0824 1
Schistosoma mansoni importin-beta 2 0.0024 0.0051 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0091 0.0183
Loa Loa (eye worm) hypothetical protein 0.0066 0.0225 0.0412
Echinococcus granulosus histone acetyltransferase KAT2B 0.0102 0.0373 0.0567
Trichomonas vaginalis CAMK family protein kinase 0.0079 0.0278 0.0571
Echinococcus multilocularis inositol monophosphatase 1 0.0051 0.0164 0.0164
Entamoeba histolytica hypothetical protein 0.0126 0.0472 0.5591
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0028 0.0467
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0045 0.014 0.0284
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0152 0.0578 0.0578
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0023 0.0053
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0055 0.018 0.018
Brugia malayi Bromodomain associated family protein 0.0012 0.0002 0.0004
Echinococcus granulosus remodeling and spacing factor 1 0.0012 0.0002 0.0003
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0094 0.0342 0.052
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0092 0.3692
Brugia malayi Troponin T 0.0039 0.0114 0.0269
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.003 0.0077 0.0154
Echinococcus multilocularis neuropeptide receptor A26 0.029 0.1148 0.1148
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0002 0.0029
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0018 0.0018
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0092 0.1513
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0023 0.0048 0.0048
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase NIMA-interacting 4, putative 0.0108 0.0397 0.6518
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0026 0.0061 0.1049
Plasmodium vivax glutathione reductase, putative 0.0097 0.0354 0.612
Echinococcus granulosus Polycystic kidney disease protein 0.0043 0.0129 0.0197
Brugia malayi Niemann-Pick C1 protein precursor 0.0093 0.0336 0.079
Schistosoma mansoni zinc finger protein 0.0012 0.0002 0.0003
Loa Loa (eye worm) troponin I 0.0066 0.0225 0.0412
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.003 0.0077 0.1258
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0593 0.2395 0.2395
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0159 0.0609 1
Brugia malayi hypothetical protein 0.0251 0.0987 0.2319
Schistosoma mansoni troponin I 0.0066 0.0225 0.0342
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0091 0.0183
Loa Loa (eye worm) latrophilin receptor protein 2 0.0099 0.036 0.066
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.008 0.1702
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0032 0.0085 0.1396
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.0028 0.0067
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.008 0.1311
Plasmodium falciparum histone acetyltransferase GCN5 0.0028 0.007 0.1485
Loa Loa (eye worm) inositol-1 0.0051 0.0164 0.0301
Echinococcus granulosus histone h3 methyltransferase 0.0155 0.0591 0.0899
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0091 0.1566
Echinococcus granulosus mixed lineage leukemia protein mll 0.003 0.0076 0.0116
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0079 0.0279 0.4579
Trypanosoma brucei polo-like protein kinase 0.0159 0.0609 1
Leishmania major hypothetical protein, conserved 0.0024 0.0051 0.0835
Brugia malayi hypothetical protein 0.0012 0.0002 0.0004
Leishmania major histone-lysine N-methyltransferase, putative 0.002 0.0034 0.0564
Echinococcus granulosus chromobox protein 1 0.0204 0.0792 0.1204
Schistosoma mansoni myst histone acetyltransferase 0.0012 0.0002 0.0003
Brugia malayi SET domain containing protein 0.0019 0.0033 0.0078
Leishmania major prostaglandin f synthase, putative 0.003 0.0077 0.1258
Trichomonas vaginalis rotamase, putative 0.0077 0.0271 0.0556
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0067 0.0231 0.0231
Loa Loa (eye worm) PHD-finger family protein 0.0067 0.0227 0.0417
Giardia lamblia Telomerase catalytic subunit 0.0033 0.0091 0.0788
Brugia malayi Troponin I 0.0066 0.0225 0.0528
Schistosoma mansoni phd finger protein 0.0012 0.0002 0.0003
Trichomonas vaginalis DNA polymerase eta, putative 0.0018 0.0028 0.0055
Loa Loa (eye worm) hypothetical protein 0.0108 0.0397 0.0727
Brugia malayi N-terminal motif family protein 0.012 0.0446 0.1048
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0018 0.0028 0.0055
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0018 0.0028 0.0043
Echinococcus multilocularis histone acetyltransferase MYST2 0.017 0.0652 0.0652
Onchocerca volvulus Troponin I homolog 0.0066 0.0225 0.046
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0079 0.0279 0.4579
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.0092 0.014
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.0092 0.1179
Toxoplasma gondii PHD-finger domain-containing protein 0.0012 0.0002 0.0021
Plasmodium falciparum importin beta, putative 0.0125 0.0469 1
Brugia malayi mbt repeat family protein 0.0149 0.0567 0.1333
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.003 0.0077 0.018
Brugia malayi mbt repeat family protein 0.0149 0.0567 0.1333
Giardia lamblia Aldose reductase 0.003 0.0077 0.0606
Schistosoma mansoni rab6-interacting 0.0043 0.0129 0.0197
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0028 0.0467
Echinococcus granulosus muscleblind protein 0.0603 0.2437 0.3705
Brugia malayi Troponin T 0.0039 0.0114 0.0269
Brugia malayi hypothetical protein 0.0012 0.0002 0.0004
Onchocerca volvulus 0.003 0.0077 0.0154
Echinococcus granulosus geminin 0.0612 0.2474 0.3761
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0091 0.0183
Echinococcus granulosus intermediate filament protein 0.0035 0.0096 0.0145
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0099 0.036 0.0846
Schistosoma mansoni coup transcription factor 0.0017 0.0023 0.0035
Mycobacterium ulcerans oxidoreductase 0.003 0.0077 0.0164
Trypanosoma brucei importin beta-1 subunit, putative 0.0125 0.0469 0.7702
Echinococcus multilocularis remodeling and spacing factor 1 0.0012 0.0002 0.0002
Onchocerca volvulus 0.0043 0.0129 0.0263
Echinococcus granulosus peptidyl prolyl cis trans isomerase 0.0108 0.0397 0.0603
Loa Loa (eye worm) hypothetical protein 0.0099 0.036 0.066
Echinococcus multilocularis histone acetyltransferase myst3 0.0012 0.0002 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0092 0.1513
Brugia malayi serine/threonine-protein kinase plk-2 0.0159 0.0609 0.143
Echinococcus granulosus mitogen activated protein kinase 3 0.0032 0.0085 0.0129
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0046 0.0142 0.0388
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0042
Echinococcus multilocularis expressed conserved protein 0.0087 0.0313 0.0313
Schistosoma mansoni myst-related protein 0.0018 0.0026 0.004
Loa Loa (eye worm) Smad1 0.0016 0.0018 0.0034
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0017 0.0023 0.0034
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0111 0.041 0.4815
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.0237
Schistosoma mansoni smad 0.0016 0.0018 0.0028
Plasmodium falciparum glutathione reductase 0.0034 0.0092 0.1965
Schistosoma mansoni myelin transcription factor 1 myt1 0.017 0.0652 0.0992
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0033 0.0091 0.0138
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0075 0.0264 0.4333
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0055 0.0182 0.0372
Echinococcus multilocularis chromobox protein 2 0.0033 0.0091 0.0091
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.003 0.0077 0.0077
Echinococcus granulosus lipoxygenase domain containing protein 0.0043 0.0129 0.0197
Schistosoma mansoni smad1 5 8 and 0.0016 0.0018 0.0028
Schistosoma mansoni microtubule-associated protein tau 0.1608 0.6578 1
Trichomonas vaginalis aldo-keto reductase, putative 0.003 0.0077 0.0154
Schistosoma mansoni troponin I 0.0066 0.0225 0.0342
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0079 0.0279 0.4579
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0023 0.0042
Echinococcus granulosus kelch ECH associated protein 1 like 0.0159 0.0608 0.0923
Brugia malayi hypothetical protein 0.0126 0.0472 0.1109
Brugia malayi F/Y-rich N-terminus family protein 0.0042 0.0124 0.0292
Schistosoma mansoni survival motor neuron protein 0.0119 0.0443 0.0673
Loa Loa (eye worm) hypothetical protein 0.0582 0.2352 0.431
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0023 0.0042
Loa Loa (eye worm) hypothetical protein 0.0149 0.0567 0.104
Schistosoma mansoni bromodomain containing protein 0.0212 0.0827 0.1257
Onchocerca volvulus 0.0989 0.4027 0.83
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0091 0.0183
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0023 0.0035
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0022 0.0043 0.07
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0101 0.037 0.1167
Echinococcus multilocularis aldo keto reductase 0.003 0.0077 0.0077
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0119 0.0443 0.1039
Brugia malayi MH2 domain containing protein 0.0232 0.0909 0.2135
Echinococcus multilocularis aldo keto reductase 0.003 0.0077 0.0077
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0222 0.0867 0.2833
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0002 0.0002
Echinococcus multilocularis survival motor neuron protein 1 0.0582 0.2352 0.2352
Leishmania major DNA polymerase eta, putative 0.0018 0.0028 0.0467
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.017 0.0652 0.0992
Schistosoma mansoni SET domain protein 0.0019 0.0033 0.005
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0077 0.0271 0.0497
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.005 0.0821
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0108 0.0397 0.4647
Schistosoma mansoni aldo-keto reductase 0.003 0.0077 0.0116
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0085 0.0301 0.0552
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0033 0.0091 0.1159
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0165 0.0633 0.0633
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.002 0.0034 0.0564
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0023 0.0053
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0023 0.0035
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0026 0.0061 0.0111
Brugia malayi nuclear receptor NHR-88 0.0017 0.0023 0.0053
Schistosoma mansoni hypothetical protein 0.0012 0.0002 0.0003
Echinococcus multilocularis transcription factor Dp 1 0.0049 0.0155 0.0155
Leishmania major hypothetical protein, conserved 0.0038 0.0108 0.1774
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.003 0.0077 0.0154
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0101 0.037 0.0563
Schistosoma mansoni DNA polymerase eta 0.0018 0.0028 0.0043
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0027 0.0066 0.1078
Echinococcus granulosus lipoxygenase domain containing protein 0.0043 0.0129 0.0197
Schistosoma mansoni hypothetical protein 0.0038 0.0112 0.017
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1045 0.4258 0.7803
Echinococcus multilocularis Protein lozenge 0.0111 0.0412 0.0412
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0023 0.0023
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.003 0.0077 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0005 0.0084
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0023 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0055 0.0182 0.0372
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0023 0.0035
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0043 0.0128 0.0195
Schistosoma mansoni chromobox protein 0.0033 0.0091 0.0138
Echinococcus granulosus microtubule associated protein 2 0.1608 0.6578 1
Trichomonas vaginalis chromobox protein, putative 0.0033 0.0091 0.0183
Schistosoma mansoni aldehyde dehydrogenase 0.0101 0.037 0.0563
Trypanosoma brucei DNA polymerase eta, putative 0.0018 0.0028 0.0467
Loa Loa (eye worm) PHD-finger family protein 0.0012 0.0002 0.0003
Plasmodium falciparum heterochromatin protein 1 0.0033 0.0091 0.1932
Trypanosoma cruzi DNA polymerase eta, putative 0.0018 0.0028 0.0467
Plasmodium falciparum telomerase reverse transcriptase 0.0033 0.0091 0.1942
Brugia malayi Troponin family protein 0.0066 0.0225 0.0528
Loa Loa (eye worm) MH2 domain-containing protein 0.0232 0.0909 0.1666
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0091 0.0807
Echinococcus granulosus aldehyde reductase 0.0021 0.0041 0.0062
Echinococcus granulosus TAF3 RNA polymerase II TATA box binding protein 0.0012 0.0002 0.0003
Echinococcus granulosus Chromo domain 0.0033 0.0091 0.0138
Onchocerca volvulus 0.0019 0.0033 0.0065
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.0092 0.1513
Schistosoma mansoni jumonji/arid domain-containing protein 0.0054 0.0177 0.0269
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0207 0.0805 0.1223
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0211 0.0824 0.1695
Leishmania major hypothetical protein, conserved 0.002 0.0034 0.0564
Trichomonas vaginalis aldo/keto reductase, putative 0.003 0.0077 0.0154
Echinococcus multilocularis Chromobox protein 3 0.0033 0.0091 0.0091
Brugia malayi glucose-6-phosphate dehydrogenase 0.0067 0.0231 0.0542
Schistosoma mansoni dpf3 0.0012 0.0002 0.0003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0099 0.036 0.036
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0067 0.0231 1
Echinococcus multilocularis transportin 1 0.0024 0.0051 0.0051
Echinococcus granulosus translational activator gcn1 0.0024 0.0051 0.0077
Trypanosoma brucei trypanothione reductase 0.0097 0.0354 0.5814
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0017 0.0022 0.0033
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0038 0.0112 0.1428
Trichomonas vaginalis bromodomain-containing protein, putative 0.0038 0.0112 0.0227
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0034 0.0092 0.0218
Onchocerca volvulus Bile acid receptor homolog 0.0017 0.0023 0.0043
Echinococcus granulosus aldo keto reductase family 1 member B4 0.003 0.0077 0.0116
Echinococcus granulosus aldo keto reductase family 1 member B4 0.003 0.0077 0.0116
Loa Loa (eye worm) hypothetical protein 0.0035 0.0096 0.0175
Plasmodium falciparum ataxin-2 like protein, putative 0.0038 0.0108 0.2303
Leishmania major DNA polymerase kappa, putative 0.0018 0.0028 0.0467
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0018 0.0028 0.0043
Plasmodium vivax ataxin-2 like protein, putative 0.0038 0.0108 0.1867
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0051 0.0164 0.173
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0079 0.0279 0.3149
Schistosoma mansoni rotamase 0.0077 0.0271 0.0412
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0032 0.0085 0.1396
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.0092 0.014
Plasmodium falciparum glutathione reductase 0.0097 0.0354 0.7549
Onchocerca volvulus 0.0887 0.3608 0.7437
Echinococcus multilocularis dna polymerase kappa 0.0018 0.0028 0.0028
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0222 0.0867 0.2863
Echinococcus granulosus chromobox protein 1 0.0204 0.0792 0.1204
Mycobacterium tuberculosis Probable oxidoreductase 0.0247 0.0969 0.3212
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0091 0.0807
Loa Loa (eye worm) MBCTL1 0.017 0.0652 0.1196
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0271 0.0556
Brugia malayi Bromodomain containing protein 0.025 0.0983 0.2308
Trypanosoma brucei protein kinase, putative 0.0032 0.0085 0.1396
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0055 0.0182 0.0372
Plasmodium vivax transportin, putative 0.0024 0.0051 0.0879
Schistosoma mansoni mixed-lineage leukemia protein mll 0.003 0.0076 0.0116
Brugia malayi SET domain containing protein 0.0041 0.0122 0.0287
Echinococcus multilocularis muscleblind protein 0.0603 0.2437 0.2437
Schistosoma mansoni hypothetical protein 0.1336 0.5457 0.8295
Trypanosoma cruzi ISWI complex protein 0.0049 0.0156 0.257
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.1336 0.5457 1
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0092 0.1513
Echinococcus multilocularis histone acetyltransferase myst4 0.0012 0.0002 0.0002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0026 0.0061 0.0997
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0005 0.0084
Leishmania major aldo-keto reductase-like protein 0.003 0.0077 0.1258
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0023 0.0053
Onchocerca volvulus Protein ultraspiracle homolog 0.0017 0.0023 0.0043
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0211 0.0824 0.1695
Echinococcus granulosus phd finger protein 10 0.0012 0.0002 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0055 0.0182 0.0372
Trichomonas vaginalis CAMK family protein kinase 0.0159 0.0609 0.1252
Trypanosoma cruzi aldo/keto reductase, putative 0.003 0.0077 0.1258
Echinococcus multilocularis PHD and RING finger domain containing protein 1 0.0012 0.0002 0.0002
Schistosoma mansoni importin beta-1 0.0125 0.0469 0.0713
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0092 0.1513
Plasmodium vivax multidomain scavenger receptor, putative 0.0043 0.0129 0.2238
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0091 0.0807
Loa Loa (eye worm) oxidoreductase 0.003 0.0077 0.014
Echinococcus multilocularis neuropeptide s receptor 0.029 0.1148 0.1148
Entamoeba histolytica deoxycytidyl transferase, putative 0.0018 0.0028 0.0027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0092 0.1513
Brugia malayi hypothetical protein 0.0024 0.0053 0.0125
Loa Loa (eye worm) hypothetical protein 0.0066 0.0225 0.0412
Entamoeba histolytica HEAT repeat domain containing protein 0.0024 0.0051 0.0308
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0612 0.2474 0.3761
Mycobacterium tuberculosis Probable reductase 0.0222 0.0867 0.2863
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0026 0.0061 0.0092
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0003
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.003 0.0077 0.1258
Loa Loa (eye worm) hypothetical protein 0.0989 0.4027 0.738
Toxoplasma gondii hypothetical protein 0.002 0.0034 0.0439
Trichomonas vaginalis aldo-keto reductase, putative 0.003 0.0077 0.0154
Loa Loa (eye worm) hypothetical protein 0.012 0.0446 0.0818
Loa Loa (eye worm) hypothetical protein 0.0033 0.0091 0.0166
Trichomonas vaginalis aldo-keto reductase, putative 0.003 0.0077 0.0154
Plasmodium falciparum thioredoxin reductase 0.0034 0.0092 0.1965
Onchocerca volvulus 0.003 0.0077 0.0154
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.008 0.008
Trichomonas vaginalis aldo-keto reductase, putative 0.003 0.0077 0.0154
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0085 0.0305 0.0464
Echinococcus granulosus histone acetyltransferase MYST2 0.017 0.0652 0.0992
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0023 0.0042
Plasmodium vivax SET domain containing protein 0.0018 0.0027 0.0463
Echinococcus granulosus cpg binding protein 0.011 0.0405 0.0615
Brugia malayi Hypothetical C28H8.9 in chromosome III 0.0012 0.0002 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0091 0.0183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0094 0.0342 0.0627
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0018 0.0028
Brugia malayi Bromodomain containing protein 0.0126 0.0472 0.111
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.0092 0.1965
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0152 0.0578 0.7398
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0028 0.0467
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0076 0.0076
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0149 0.0567 0.1167
Echinococcus multilocularis kelch ECH associated protein 1 0.0159 0.0608 0.0608
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0211 0.0824 0.1695
Echinococcus granulosus histone acetyltransferase myst4 0.0012 0.0002 0.0003
Echinococcus granulosus aldo keto reductase 0.003 0.0077 0.0116
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0211 0.0824 0.1695
Loa Loa (eye worm) hypothetical protein 0.0577 0.2331 0.4271
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0085 0.0301 0.0458
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0165 0.0633 0.0963
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0093 0.0336 0.3891
Giardia lamblia Fructose-bisphosphate aldolase 0.0211 0.0824 1
Echinococcus multilocularis dnaJ subfamily B 0.1181 0.482 0.482
Plasmodium falciparum transportin 0.0024 0.0051 0.1084
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0055 0.0182 0.0372
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0026 0.0061 0.0997
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0067 0.0231 0.0351
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0028 0.0467
Trichomonas vaginalis ap endonuclease, putative 0.0026 0.0061 0.0122
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0085 0.0301 0.4952
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0247 0.0969 0.3212
Onchocerca volvulus Huntingtin homolog 0.0251 0.0987 0.2032
Trichomonas vaginalis CAMK family protein kinase 0.0159 0.0609 0.1252
Schistosoma mansoni zinc finger protein 0.0012 0.0002 0.0003
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0024 0.0051 0.0835
Trypanosoma cruzi histone-lysine N-methyltransferase, putative 0.002 0.0034 0.0564
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0018 0.0018
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0038 0.0112 0.0227
Schistosoma mansoni sex comb on midleg homolog 0.0149 0.0567 0.0863
Giardia lamblia Histone acetyltransferase GCN5 0.0028 0.007 0.0519
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0042
Brugia malayi Pre-SET motif family protein 0.1045 0.4258 1
Leishmania major hypothetical protein, conserved 0.002 0.0034 0.0564
Echinococcus granulosus histone acetyltransferase myst3 0.0012 0.0002 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0091 0.0183
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0042
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0035 0.0096 0.0175
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0211 0.0824 1
Echinococcus granulosus inositol monophosphatase 1 0.0051 0.0164 0.025
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0023 0.0035
Brugia malayi isocitrate dehydrogenase 0.0031 0.008 0.0187
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0055 0.013
Loa Loa (eye worm) hypothetical protein 0.0033 0.0091 0.0166
Schistosoma mansoni cpg binding protein 0.011 0.0405 0.0615
Echinococcus granulosus troponin i 0.0066 0.0225 0.0342
Echinococcus granulosus aldo keto reductase 0.003 0.0077 0.0116
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.0092 0.0187
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.004 0.0118 0.0216
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0028 0.0467
Echinococcus granulosus kelch ECH associated protein 1 like 0.0159 0.0608 0.0923
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0023 0.0035
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0032 0.0085 0.1396
Trichomonas vaginalis ap endonuclease, putative 0.0026 0.0061 0.0122
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0003
Trypanosoma cruzi ISWI complex protein 0.0049 0.0156 0.257
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0079 0.0279 0.3566
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0211 0.0824 0.1695
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0577 0.2331 0.5474
Echinococcus granulosus aldo keto reductase family 1 member B4 0.003 0.0077 0.0116
Trypanosoma brucei unspecified product 0.0013 0.0005 0.0084
Toxoplasma gondii histone lysine methyltransferase SET1 0.0201 0.0782 1
Trichomonas vaginalis Heterochromatin protein, putative 0.0033 0.0091 0.0183
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0085 0.0301 0.0708
Loa Loa (eye worm) doublecortin family protein 0.0043 0.0129 0.0237
Entamoeba histolytica serine/threonine protein kinase, putative 0.0159 0.0609 0.7306
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0128 0.0128
Schistosoma mansoni aldehyde dehydrogenase 0.0101 0.037 0.0563
Brugia malayi parvulin-type peptidyl-prolyl cis-trans isomerase, Bm parvulin 0.0108 0.0397 0.0932
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0101 0.0371 0.0762
Schistosoma mansoni hypothetical protein 0.0159 0.0609 0.0926
Trichomonas vaginalis aldo-keto reductase, putative 0.003 0.0077 0.0154
Echinococcus multilocularis troponin i 0.0066 0.0225 0.0225
Echinococcus multilocularis Zinc finger, DBF type 0.0012 0.0002 0.0002
Echinococcus granulosus aldo keto reductase family 1 member B4 0.003 0.0077 0.0116
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0163 0.0625 0.095
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0045 0.0089
Plasmodium vivax SET domain protein, putative 0.0152 0.0578 1
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.0423 0.087
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.0092 0.0187
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0312 0.124 0.2272
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0073 0.0256 0.0524
Echinococcus multilocularis protein patched 0.004 0.0118 0.0118
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0045 0.0139 0.0211
Brugia malayi exodeoxyribonuclease III family protein 0.0026 0.0061 0.0142
Onchocerca volvulus 0.0033 0.0091 0.0183
Schistosoma mansoni troponin t invertebrate 0.0082 0.029 0.0441
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0023 0.0053
Echinococcus granulosus Smad4 0.0016 0.0018 0.0028
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0066 0.0225 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0023 0.0053
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.003 0.0077 0.0077
Echinococcus granulosus lamin 0.0035 0.0096 0.0145
Trypanosoma brucei importin beta-1 subunit, putative 0.0125 0.0469 0.7702
Echinococcus granulosus Protein patched homolog 1 0.004 0.0118 0.0179
Trypanosoma brucei ISWI complex protein 0.0049 0.0156 0.257
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0144 0.0547 0.0831
Schistosoma mansoni chromobox protein 0.0204 0.0792 0.1204
Brugia malayi Smad1 0.0016 0.0018 0.0043
Brugia malayi MH2 domain containing protein 0.0016 0.0018 0.0043
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0026 0.0061 0.011
Schistosoma mansoni polycystin 1-related 0.0043 0.0129 0.0197
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0075 0.0264 0.4333
Echinococcus multilocularis SAM and MBT domain containing protein 0.0149 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0207 0.0805 0.1475
Entamoeba histolytica aldose reductase, putative 0.003 0.0077 0.0631
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase NIMA-interacting 4, putative 0.0108 0.0397 0.6518
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0103 0.0378 0.1157
Leishmania major GTP-binding protein, putative 0.0079 0.0279 0.4579
Schistosoma mansoni hypothetical protein 0.0119 0.0443 0.0673
Brugia malayi hypothetical protein 0.0043 0.0129 0.0304
Trichomonas vaginalis CAMK family protein kinase 0.0159 0.0609 0.1252
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0222 0.0867 0.2863
Echinococcus multilocularis cpg binding protein 0.011 0.0405 0.0405
Trypanosoma brucei histone-lysine n-methyltransferase 0.002 0.0034 0.0564
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0003
Brugia malayi jmjC domain containing protein 0.0043 0.0128 0.0302
Trichomonas vaginalis aldo-keto reductase, putative 0.003 0.0077 0.0154
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0033 0.0091 0.1932
Trypanosoma cruzi Ring finger domain/PHD-finger, putative 0.0012 0.0002 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0045 0.0089
Loa Loa (eye worm) hypothetical protein 0.0146 0.0553 0.1014
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0038 0.0112 0.1428
Toxoplasma gondii exonuclease III APE 0.0026 0.0061 0.0776
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0247 0.0969 0.3212
Schistosoma mansoni sex comb on midleg homolog 0.0149 0.0567 0.0863
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0042
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0092 0.3692
Echinococcus multilocularis RUN 0.0043 0.0129 0.0129
Schistosoma mansoni phd finger protein 0.0012 0.0002 0.0003
Echinococcus multilocularis lipoxygenase domain containing protein 0.0043 0.0129 0.0129
Brugia malayi PHD-finger family protein 0.0088 0.0318 0.0746
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0027 0.0066 0.1078
Trichomonas vaginalis chromobox protein, putative 0.0204 0.0792 0.163
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0028 0.0467
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.008 0.0146
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0091 0.1566
Entamoeba histolytica hypothetical protein 0.0126 0.0472 0.5591
Loa Loa (eye worm) hypothetical protein 0.0251 0.0987 0.1809
Loa Loa (eye worm) oxidoreductase 0.003 0.0077 0.014
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0073 0.0256 0.5453
Schistosoma mansoni hypothetical protein 0.0012 0.0002 0.0003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0023 0.0023
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.008 0.0121
Plasmodium vivax telomerase reverse transcriptase, putative 0.0033 0.0091 0.1575
Loa Loa (eye worm) intermediate filament protein 0.0035 0.0096 0.0175
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0085 0.0301 0.0301
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0023 0.0035
Echinococcus multilocularis snurportin 1 0.1336 0.5457 0.5457
Loa Loa (eye worm) oxidoreductase 0.003 0.0077 0.014
Echinococcus multilocularis importin 5 0.0024 0.0051 0.0051
Schistosoma mansoni lamin 0.0035 0.0096 0.0145
Echinococcus multilocularis lamin dm0 0.0035 0.0096 0.0096
Loa Loa (eye worm) runx1 0.0111 0.0412 0.0755
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0023 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0023 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0118 0.0239
Brugia malayi Thioredoxin reductase 0.0097 0.0354 0.0831
Entamoeba histolytica hypothetical protein 0.0027 0.0066 0.0494
Loa Loa (eye worm) F/Y-rich family protein 0.0012 0.0002 0.0003
Echinococcus multilocularis thyroid hormone receptor alpha 0.0017 0.0023 0.0023
Schistosoma mansoni methyl-cpg binding protein mbd 0.0055 0.018 0.0273
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0044 0.0133 0.0271
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0044 0.0135 0.0363
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.003 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0003
Toxoplasma gondii SWI2/SNF2-containing PHD finger protein 0.0012 0.0002 0.0021
Schistosoma mansoni hypothetical protein 0.0067 0.0227 0.0346
Brugia malayi Doublecortin family protein 0.0043 0.0129 0.0304
Schistosoma mansoni fyve-containing 0.0012 0.0002 0.0003
Loa Loa (eye worm) transcription factor SMAD2 0.0232 0.0909 0.1666
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0052 0.0168 0.2761
Echinococcus granulosus dnaJ subfamily B 0.1181 0.482 0.7326
Echinococcus granulosus aldo keto reductase family 1 member B4 0.003 0.0077 0.0116
Brugia malayi Valyl-tRNA synthetase 0.0033 0.0091 0.0213
Loa Loa (eye worm) hypothetical protein 0.0603 0.2437 0.4466
Echinococcus multilocularis microtubule associated protein 2 0.1608 0.6578 0.6578
Trichomonas vaginalis chromobox protein, putative 0.0123 0.0459 0.0943
Schistosoma mansoni ap endonuclease 0.0026 0.0061 0.0092
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.004
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0247 0.0969 0.3183
Echinococcus granulosus neuropeptide s receptor 0.029 0.1148 0.1745
Loa Loa (eye worm) CXXC zinc finger family protein 0.0098 0.0356 0.0653
Loa Loa (eye worm) hypothetical protein 0.0093 0.0336 0.0617
Brugia malayi MH2 domain containing protein 0.0016 0.0018 0.0043
Echinococcus multilocularis lysine specific demethylase 5B 0.0012 0.0002 0.0002
Schistosoma mansoni lozenge 0.0111 0.0412 0.0626
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.003 0.0077 0.0077
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0085 0.0301 0.0458
Echinococcus granulosus fetal alzheimer antigen falz 0.0078 0.0276 0.0419
Loa Loa (eye worm) hypothetical protein 0.0114 0.0423 0.0776
Schistosoma mansoni methyl-cpg binding protein mbd 0.0055 0.018 0.0273
Brugia malayi Protein cec-1. 0.0033 0.0091 0.0213
Loa Loa (eye worm) histone methyltransferase 0.0036 0.0101 0.0185
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0051 0.0164 0.2697
Brugia malayi ecdysteroid receptor 0.0017 0.0023 0.0053
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0129 0.276
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0027 0.0066 0.1078
Trichomonas vaginalis hypothetical protein 0.0079 0.028 0.0575
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0067 0.0231 0.2232
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0091 0.0183
Loa Loa (eye worm) hypothetical protein 0.0155 0.0591 0.1084
Entamoeba histolytica aldose reductase, putative 0.003 0.0077 0.0631
Echinococcus granulosus Niemann Pick C1 protein 0.0133 0.0501 0.0761
Trichomonas vaginalis CAMK family protein kinase 0.0159 0.0609 0.1252
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0026 0.0061 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.014 0.0284
Brugia malayi hypothetical protein 0.0038 0.0108 0.0254
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0092 0.1513
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0023 0.0035
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0032 0.0085 0.1396
Schistosoma mansoni histone J3 methyltransferase 0.0155 0.0591 0.0899
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0091 0.0183
Schistosoma mansoni hepatitis B virus X associated protein hbxa 0.0012 0.0002 0.0003
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0028 0.0467
Brugia malayi nuclear hormone receptor 0.0017 0.0023 0.0053
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.0092 0.1513
Echinococcus multilocularis PHD finger protein 14 0.0012 0.0002 0.0002
Loa Loa (eye worm) acetyltransferase 0.0112 0.0416 0.0763
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0078 0.0276 0.0419
Schistosoma mansoni zinc finger protein 0.0071 0.0247 0.0375
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0018 0.0029 0.0054
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.0092 0.0216
Schistosoma mansoni hypothetical protein 0.1181 0.482 0.7326
Trypanosoma brucei telomerase reverse transcriptase 0.0033 0.0091 0.1496
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0079 0.0279 0.0511
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0066 0.0132
Schistosoma mansoni intermediate filament proteins 0.0035 0.0096 0.0145
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.005 0.0821
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0051 0.0164 0.0463
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0026 0.0061 0.0997
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0159 0.0609 0.0609
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0023 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0028 0.0467
Plasmodium vivax heterochromatin protein 1, putative 0.0033 0.0091 0.1566
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0028 0.0467
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0222 0.0867 0.2863
Echinococcus multilocularis expressed protein 0.0077 0.0271 0.0271
Schistosoma mansoni troponin I 0.0066 0.0225 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0023 0.0053
Loa Loa (eye worm) hypothetical protein 0.0033 0.0091 0.0166
Brugia malayi CHD4 protein 0.0045 0.0139 0.0326
Loa Loa (eye worm) hypothetical protein 0.0251 0.0987 0.1809
Schistosoma mansoni hypothetical protein 0.0099 0.036 0.0548
Echinococcus multilocularis aldo keto reductase 0.003 0.0077 0.0077
Trichomonas vaginalis CAMK family protein kinase 0.0159 0.0609 0.1252
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0028 0.0467
Loa Loa (eye worm) hypothetical protein 0.0038 0.0108 0.0198
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0085 0.0301 0.4952
Leishmania major hypothetical protein, conserved 0.0049 0.0156 0.257
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0092 0.1513
Trichomonas vaginalis CAMK family protein kinase 0.0159 0.0609 0.1252
Trypanosoma brucei Ring finger domain/PHD-finger, putative 0.0012 0.0002 0.0027
Trypanosoma cruzi Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.002 0.0034 0.0564
Echinococcus granulosus transcription factor Dp 1 0.0049 0.0155 0.0235
Loa Loa (eye worm) hypothetical protein 0.0228 0.0892 0.1635
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.003 0.0077 0.0154
Schistosoma mansoni hypothetical protein 0.0612 0.2474 0.3761
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0103 0.0378 0.1195
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0026 0.0061 0.0406
Trypanosoma brucei prostaglandin f synthase 0.003 0.0077 0.1258
Echinococcus granulosus phd finger protein 12 0.0012 0.0002 0.0003
Echinococcus multilocularis histone h3 methyltransferase 0.0155 0.0591 0.0591
Brugia malayi CHE-14 protein 0.004 0.0118 0.0276
Loa Loa (eye worm) hypothetical protein 0.003 0.0077 0.014
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0101 0.037 0.6084
Schistosoma mansoni smad1 5 8 and 0.0016 0.0018 0.0028
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0052
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.008 0.008
Schistosoma mansoni loxhd1 0.0043 0.0129 0.0197
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0051 0.0164 0.2697
Loa Loa (eye worm) hypothetical protein 0.0034 0.0093 0.017
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0051 0.0164 0.2697
Trichomonas vaginalis aldo-keto reductase, putative 0.003 0.0077 0.0154
Echinococcus granulosus importin subunit beta 1 0.0125 0.0469 0.0713
Loa Loa (eye worm) hypothetical protein 0.0108 0.0397 0.0727
Echinococcus granulosus oncosphere protein Tso22e 0.0082 0.029 0.0441
Mycobacterium ulcerans aldehyde dehydrogenase 0.0101 0.037 0.1167
Trichomonas vaginalis CMGC family protein kinase 0.0032 0.0085 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0023 0.0053
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0055 0.013
Trichomonas vaginalis rotamase, putative 0.0075 0.0264 0.054
Echinococcus granulosus dna polymerase kappa 0.0018 0.0028 0.0043
Echinococcus granulosus dna polymerase eta 0.0018 0.0028 0.0043
Toxoplasma gondii HEAT repeat-containing protein 0.0024 0.0051 0.065
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0026 0.0061 0.0936
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0045 0.0139 0.0139
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0085 0.0301 0.3452
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0103 0.0378 0.1195
Loa Loa (eye worm) glutathione reductase 0.0097 0.0354 0.0649
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0211 0.0824 0.1695
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0023 0.0053
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0067 0.0231 0.0691
Schistosoma mansoni tsg101-related 0.0111 0.041 0.0623
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.017 0.0652 0.0652
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0023 0.0035
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0092 0.1513
Trichomonas vaginalis chromobox protein, putative 0.0204 0.0792 0.163
Mycobacterium tuberculosis Probable oxidoreductase 0.003 0.0077 0.0164
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0003
Echinococcus multilocularis muscleblind protein 1 0.0603 0.2437 0.2437
Loa Loa (eye worm) hypothetical protein 0.0163 0.0625 0.1145
Echinococcus granulosus uro adherence factor A 0.0012 0.0002 0.0003
Trichomonas vaginalis aldo-keto reductase, putative 0.003 0.0077 0.0154
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0023 0.0035
Schistosoma mansoni rab6-interacting 0.0043 0.0129 0.0197
Loa Loa (eye worm) hypothetical protein 0.0213 0.0833 0.1526
Echinococcus multilocularis geminin 0.0612 0.2474 0.2474
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0066 0.1078
Echinococcus multilocularis musashi 0.0035 0.0096 0.0096
Brugia malayi glutathione reductase 0.0097 0.0354 0.0831
Echinococcus granulosus polycomb protein SCMH1 0.0149 0.0567 0.0863
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0034 0.0092 0.0218
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0042
Leishmania major hypothetical protein, conserved 0.0052 0.0168 0.2761
Echinococcus multilocularis Chromo domain 0.0033 0.0091 0.0091
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.008 0.1311
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0027 0.0066 0.1078
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0023 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0055 0.0182 0.0372
Schistosoma mansoni chromobox protein 0.0204 0.0792 0.1204
Plasmodium vivax importin-beta 2, putative 0.0125 0.0469 0.8108
Schistosoma mansoni hypothetical protein 0.0012 0.0002 0.0003
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0052 0.0168 0.2761
Entamoeba histolytica hypothetical protein 0.0033 0.0091 0.0807
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0045 0.0089
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0032 0.0085 0.1396
Trichomonas vaginalis hypothetical protein 0.0033 0.0091 0.0183
Echinococcus granulosus aldo keto reductase family 1 member B4 0.003 0.0077 0.0116
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0085 0.0301 0.4952
Loa Loa (eye worm) PHD-finger family protein 0.0012 0.0002 0.0003
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.003 0.0077 0.0077
Entamoeba histolytica hypothetical protein 0.0027 0.0066 0.0494
Echinococcus granulosus PHD and RING finger domain containing protein 1 0.0012 0.0002 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0091 0.0183
Echinococcus multilocularis Niemann Pick C1 protein 0.0093 0.0336 0.0336
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.0092 0.0801
Schistosoma mansoni jumonji/arid domain-containing protein 0.0054 0.0177 0.0269
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0082 0.029 0.0595
Brugia malayi Latrophilin receptor protein 2 0.0099 0.036 0.0846
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0079 0.0279 0.4821
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0092 0.1513
Schistosoma mansoni tsg101-related 0.0136 0.0513 0.0779
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0023 0.0023
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.008 0.0121
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.0177 0.0324

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 18000 nM Competitive inhibition of recombinant human DOT1L using adenosine/deazaadenosine as substrate and SAM cofactor ChEMBL. 23879463
Ki (binding) = 18 uM Inhibition of human recombinant DOT1L catalytic domain amino acid (1 to 472) using [3H]-SAM after 30 mins by scintillation counter ChEMBL. 22924785

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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