Detailed information for compound 170753

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 459.534 | Formula: C28H29NO5
  • H donors: 1 H acceptors: 3 LogP: 5.68 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCc1ccc2c(n1)[C@@H](c1ccc(cc1)OC)[C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O
  • InChi: 1S/C28H29NO5/c1-3-4-5-6-19-10-13-21-24(18-9-14-22-23(15-18)34-16-33-22)26(28(30)31)25(27(21)29-19)17-7-11-20(32-2)12-8-17/h7-15,24-26H,3-6,16H2,1-2H3,(H,30,31)/t24-,25-,26+/m0/s1
  • InChiKey: FHOLSLVTQPRBKJ-KKUQBAQOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens endothelin receptor type B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0004 0.0001
Plasmodium falciparum importin beta, putative 0.0028 0.0065 0.0809
Echinococcus multilocularis microtubule associated protein 2 0.1337 0.6633 0.6632
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0198 0.0195
Schistosoma mansoni ferritin light chain 0.0025 0.0053 0.0053
Plasmodium falciparum endoplasmin, putative 0.0019 0.0022 0.0238
Loa Loa (eye worm) hypothetical protein 0.0071 0.0279 0.0317
Echinococcus granulosus alkaline phosphatase 0.016 0.0726 0.0723
Schistosoma mansoni thyroid hormone receptor 0.003 0.0075 0.0075
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0051 0.0102
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0108 0.0105
Schistosoma mansoni alkaline phosphatase 0.016 0.0726 0.0726
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0083 0.0288
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0085 0.0189
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.025 0.0866
Leishmania major sphingosine kinase A, B, putative 0.0068 0.0267 0.0924
Trypanosoma brucei heat shock protein, putative 0.0032 0.0083 0.0288
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0317 0.11
Trichomonas vaginalis chaperonin, putative 0.0024 0.0043 0.0082
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.059 0.2885 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0083 0.0288
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0232 0.0806
Plasmodium falciparum DNA repair protein REV1, putative 0.0016 0.0006 0.0028
Giardia lamblia Sgs1 DNA helicase, putative 0.0018 0.0017 0.0146
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.007 0.015
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0171 0.0168
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0167 0.0763 0.2646
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0075 0.0083
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0085 0.0189
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0087 0.0084
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.0317 0.11
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0006 0.0006
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0108 0.0248
Trypanosoma brucei heat shock protein, putative 0.0032 0.0083 0.0288
Brugia malayi MH2 domain containing protein 0.0016 0.0006 0.0005
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0052 0.0186 0.0186
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0004 0.0013
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0221 0.0221
Schistosoma mansoni bromodomain containing protein 0.0016 0.0004 0.0004
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0044 0.0152
Mycobacterium ulcerans beta-lactamase 0.0071 0.0279 0.0314
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0059 0.0219 0.0758
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0000097187
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.025 0.0866
Leishmania major heat shock protein 83-1 0.0032 0.0083 0.0288
Brugia malayi Endoplasmin precursor 0.0032 0.0083 0.0201
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0026 0.0053 0.005
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0044 0.0152
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0381 0.0434
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0108 0.0105
Trichomonas vaginalis DNA polymerase eta, putative 0.0078 0.0317 0.0778
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.007 0.087
Echinococcus granulosus ferritin 0.0025 0.0053 0.0049
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0279 0.0279
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.1424 0.1633
Trichomonas vaginalis bmru protein, putative 0.0068 0.0267 0.065
Mycobacterium ulcerans DNA polymerase IV 0.0078 0.0317 0.0358
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0028 0.0097
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0279 0.1325 0.4595
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0167 0.0763 1
Schistosoma mansoni hypothetical protein 0.0204 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0083
Brugia malayi diacylglycerol kinase 0.0068 0.0267 0.0666
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.003 0.0076 0.0076
Schistosoma mansoni alkaline phosphatase 0.016 0.0726 0.0726
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0043 0.0043
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.059 0.2885 1
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0043 0.0082
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0108 0.0376
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0052 0.0186 0.021
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0137 0.0477
Schistosoma mansoni smad1 5 8 and 0.0016 0.0006 0.0006
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0075 0.0072
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0004 0.0002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0108 0.1356
Brugia malayi Ceramide kinase 0.0068 0.0267 0.0666
Trypanosoma brucei chrX additional, unordered contigs 0.0016 0.0006 0.002
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0075 0.0072
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0068 0.0267 0.0267
Mycobacterium leprae Probable lipase LipE 0.0071 0.0279 0.3257
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0089 0.02
Echinococcus multilocularis ceramide kinase 0.0068 0.0267 0.0263
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0083
Mycobacterium tuberculosis Conserved protein 0.0071 0.0279 0.0315
Entamoeba histolytica hypothetical protein 0.0023 0.0039 0.0024
Schistosoma mansoni apoferritin-2 0.0025 0.0053 0.0053
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0083 0.0288
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0028 0.0321
Brugia malayi nuclear hormone receptor 0.003 0.0075 0.0182
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0089 0.0217
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0043 0.01
Echinococcus multilocularis Smad4 0.0016 0.0006 0.0002
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0462 0.1146
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0075 0.0072
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0075 0.0075
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0017 0.0033
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0196 0.0909 0.0906
Brugia malayi Bloom's syndrome protein homolog 0.0045 0.0148 0.0366
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0001
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0017 0.0102
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0221 0.0217
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0000097187
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0005 0.0018
Loa Loa (eye worm) hypothetical protein 0.0071 0.0279 0.0317
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0004 0.0004
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0083 0.0184
Onchocerca volvulus 0.0071 0.0279 0.2201
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0147 0.0346
Trichomonas vaginalis DNA helicase recq1, putative 0.0045 0.0148 0.0349
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0075 0.0182
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0051 0.0047
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0005 0.0018
Schistosoma mansoni sphingosine kinase A B 0.175 0.8706 0.8706
Toxoplasma gondii exonuclease III APE 0.0037 0.0108 0.0809
Loa Loa (eye worm) hypothetical protein 0.0135 0.0604 0.069
Loa Loa (eye worm) hypothetical protein 0.0068 0.0267 0.0302
Echinococcus multilocularis expressed protein 0.0033 0.0089 0.0086
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0046 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0075 0.0182
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0108 0.0248
Brugia malayi beta-lactamase 0.0071 0.0279 0.0699
Leishmania major heat shock protein 83-1 0.0032 0.0083 0.0288
Trypanosoma brucei unspecified product 0.0072 0.0285 0.0987
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.0462 0.0462
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0075 0.0182
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0068 0.0267 0.0267
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0075 0.028
Echinococcus granulosus dna polymerase kappa 0.0078 0.0317 0.0314
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0165 0.0161
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0006 0.0003
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0462 0.58
Loa Loa (eye worm) hypothetical protein 0.0119 0.0522 0.0595
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0018 0.0017 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0001
Entamoeba histolytica diacylglycerol kinase, putative 0.0068 0.0267 0.0287
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0085 0.0296
Schistosoma mansoni hypothetical protein 0.0204 0.0949 0.0949
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0006 0.002
Entamoeba histolytica hypothetical protein, conserved 0.175 0.8706 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0041 0.0131 0.0985
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0085 0.063
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0381 0.0956
Leishmania major hypothetical protein, conserved 0.0071 0.0279 0.0968
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.0653 0.0653
Trichomonas vaginalis endoplasmin, putative 0.0019 0.0022 0.0028
Loa Loa (eye worm) glutaminase 2 0.0802 0.395 0.4535
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.0148 0.0349
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0085 0.0189
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0462 0.0527
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.001 0.0006
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0004 0.0000097187
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0075 0.0083
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0001
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.007 0.087
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0108 0.138
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0046 0.0032
Leishmania major DNA damage repair protein, putative 0.0016 0.0006 0.002
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0221 0.0217
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0075 0.0072
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0083 0.0091
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0068 0.0267 0.0302
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0000097187
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0277 0.0273
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0068 0.0267 0.0263
Leishmania major heat shock protein 83-1 0.0032 0.0083 0.0288
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0118 0.1502
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0006 0.0002
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0279 0.0682
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0004 0.0004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0011 0.000000000096554
Echinococcus multilocularis cpg binding protein 0.0151 0.0682 0.0678
Plasmodium falciparum heat shock protein 90 0.0032 0.0083 0.1044
Leishmania major heat shock protein 83-1 0.0032 0.0083 0.0288
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0075 0.0075
Trichomonas vaginalis glutaminase, putative 0.0802 0.395 1
Brugia malayi RNA, U transporter 1 0.008 0.0324 0.0812
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0083 0.0341 0.1181
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0009 0.0009
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0005 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0267 0.065
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0083 0.1044
Loa Loa (eye worm) RecQ helicase 0.0045 0.0148 0.0166
Loa Loa (eye worm) hypothetical protein 0.0071 0.0279 0.0317
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0279 0.0682
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0006 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0075 0.0083
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0039 0.0071
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0462 0.1146
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.007 0.087
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0043 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0137 0.0477
Leishmania major DNA polymerase kappa, putative 0.0059 0.0219 0.0758
Echinococcus multilocularis neuropeptide s receptor 0.0907 0.4478 0.4476
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0083 0.0288
Echinococcus multilocularis fetal alzheimer antigen, falz 0.003 0.0076 0.0072
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0009 0.0005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0085 0.0189
Mycobacterium tuberculosis Conserved hypothetical protein 0.0311 0.1484 0.1699
Plasmodium vivax importin-beta 2, putative 0.0028 0.0065 0.0809
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.007 0.015
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0065 0.0061
Mycobacterium tuberculosis Conserved protein 0.0071 0.0279 0.0315
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0085 0.0296
Echinococcus multilocularis dnaJ subfamily B 0.2007 1 1
Leishmania major DNA polymerase eta, putative 0.0077 0.0312 0.1081
Leishmania major hypothetical protein, conserved 0.0068 0.0267 0.0924
Loa Loa (eye worm) hypothetical protein 0.0038 0.0114 0.0127
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0198 0.0195
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.007 0.051
Leishmania major diacylglycerol kinase, putative 0.0068 0.0267 0.0924
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0046 0.0106
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0075 0.0075
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.0653 0.1645
Trichomonas vaginalis rotamase, putative 0.0032 0.0085 0.019
Brugia malayi mbt repeat family protein 0.0048 0.0165 0.0409
Toxoplasma gondii diacylglycerol kinase, putative 0.0068 0.0267 0.2029
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0279 0.0315
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0005 0.0012
Brugia malayi hypothetical protein 0.0016 0.0004 0.0002
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0005 0.0018
Leishmania major GTP-binding protein, putative 0.0021 0.0028 0.0097
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0039 0.0071
Schistosoma mansoni blooms syndrome DNA helicase 0.0035 0.0101 0.0101
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.025 0.0246
Entamoeba histolytica phosphoglycerate kinase, putative 0.0167 0.0763 0.0858
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0075 0.0072
Schistosoma mansoni hypothetical protein 0.0172 0.0789 0.0789
Trypanosoma brucei heat shock protein, putative 0.0032 0.0083 0.0288
Echinococcus granulosus heat shock protein 90 0.0025 0.0051 0.0047
Entamoeba histolytica hypothetical protein 0.0107 0.0462 0.0512
Brugia malayi MH2 domain containing protein 0.0237 0.1116 0.2818
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0028 0.0321
Echinococcus granulosus mixed lineage leukemia protein mll 0.0036 0.0106 0.0102
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0025 0.0053 0.0054
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0004 0.0004
Echinococcus granulosus heat shock protein 90 0.0032 0.0083 0.0079
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0015 0.0011
Trypanosoma cruzi diacylglycerol kinase, putative 0.0068 0.0267 0.0924
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0279 0.1325 0.4595
Loa Loa (eye worm) hypothetical protein 0.0028 0.0065 0.0071
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0083 0.0612
Brugia malayi latrophilin 2 splice variant baaae 0.0441 0.2137 0.5406
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0279 0.0315
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0277 0.0273
Trypanosoma brucei heat shock protein, putative 0.0032 0.0083 0.0288
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0317 0.11
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0025 0.0053 0.0096
Schistosoma mansoni DNA polymerase IV / kappa 0.0016 0.0006 0.0006
Schistosoma mansoni smad1 5 8 and 0.0016 0.0006 0.0006
Schistosoma mansoni thyroid hormone receptor 0.003 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0001
Leishmania major heat shock protein 83-1 0.0032 0.0083 0.0288
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0645 0.3161 0.3628
Loa Loa (eye worm) hypothetical protein 0.0043 0.0143 0.016
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.007 0.015
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0006 0.002
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0083 0.0075
Echinococcus granulosus microtubule associated protein 2 0.1337 0.6633 0.6632
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0028 0.0024
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0108 0.081
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0108 0.0121
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0108 0.0266
Onchocerca volvulus 0.0071 0.0279 0.2201
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0087 0.0087
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0005 0.0021
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0108 0.0118
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0052 0.0186 0.0183
Onchocerca volvulus Ceramide kinase 1 homolog 0.0068 0.0267 0.2082
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0043 0.0149
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0051 0.0102
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0221 0.0217
Trichomonas vaginalis esterase, putative 0.0071 0.0279 0.0682
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.025 0.0283
Trypanosoma brucei diacylglycerol kinase, putative 0.0068 0.0267 0.0924
Brugia malayi jmjC domain containing protein 0.0059 0.0221 0.0551
Plasmodium vivax endoplasmin, putative 0.0032 0.0083 0.1044
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0165 0.0186
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0068 0.0267 0.0924
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0381 0.0381
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0108 0.0376
Loa Loa (eye worm) hypothetical protein 0.175 0.8706 1
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0026 0.0026
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0043 0.0039
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0165 0.0165
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0083 0.0075
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.007 0.0845
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0043 0.0304
Trichomonas vaginalis bmru protein, putative 0.0068 0.0267 0.065
Schistosoma mansoni ap endonuclease 0.0037 0.0108 0.0108
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0085 0.0296
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0044 0.0085
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0048
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0075 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0085 0.0189
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0279 0.3629
Plasmodium falciparum diacylglycerol kinase, putative 0.0068 0.0267 0.3462
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0317 0.11
Trypanosoma brucei phosphoglycerate kinase 0.0061 0.0232 0.0806
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0075 0.0072
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0023 0.0038 0.0267
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0075 0.0075
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0279 0.0682
Onchocerca volvulus 0.0048 0.0165 0.1125
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0068 0.0267 0.065
Echinococcus granulosus heat shock protein 0.0032 0.0083 0.0079
Echinococcus multilocularis endoplasmin 0.0025 0.0051 0.0047
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0147 0.1886
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0075 0.0182
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0068 0.0267 0.2029
Schistosoma mansoni terminal deoxycytidyl transferase 0.0052 0.0186 0.0186
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0462 0.1601
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0204 0.0949 0.0945
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0075 0.0083
Schistosoma mansoni microtubule-associated protein tau 0.1337 0.6633 0.6633
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0004 0.0000097187
Trypanosoma brucei phosphoglycerate kinase 0.0167 0.0763 0.2646
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0001
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0039 0.0071
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.007 0.015
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0036 0.0106 0.0102
Schistosoma mansoni ferritin 0.0025 0.0053 0.0053
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0118 0.1478
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0002
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0462 0.0512
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0279 0.0276
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0028 0.0293
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.1116 0.1278
Echinococcus multilocularis Diacylglycerol kinase theta 0.0068 0.0267 0.0263
Loa Loa (eye worm) MBCTL1 0.0055 0.0198 0.0224
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0068 0.0267 0.0924
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0068 0.0267 0.0924
Schistosoma mansoni ferritin 0.0025 0.0053 0.0053
Echinococcus multilocularis geminin 0.0172 0.0789 0.0786
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0171 0.0171
Mycobacterium ulcerans diacylglycerol kinase 0.0068 0.0267 0.03
Echinococcus granulosus importin subunit beta 1 0.0028 0.0065 0.0061
Schistosoma mansoni cpg binding protein 0.0151 0.0682 0.0682
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0075 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0085 0.0189
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0279 0.0968
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0196 0.0909 0.0906
Echinococcus granulosus intestinal type alkaline phosphatase 0.016 0.0726 0.0723
Toxoplasma gondii ABC1 family protein 0.0071 0.0279 0.2127
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0267 0.0924
Trypanosoma brucei unspecified product 0.0036 0.0105 0.0364
Entamoeba histolytica Ran family GTPase 0.0021 0.0028 0.0012
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0198 0.0493
Mycobacterium ulcerans glutaminase 0.0802 0.395 0.4534
Schistosoma mansoni hypothetical protein 0.0107 0.0462 0.0462
Echinococcus granulosus dna polymerase eta 0.0077 0.0312 0.0308
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0005 0.0018
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0005 0.0002
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0029 0.0029
Treponema pallidum phosphoglycerate kinase 0.0167 0.0763 1
Schistosoma mansoni hypothetical protein 0.0299 0.1423 0.1423
Brugia malayi Calcitonin receptor-like protein seb-1 0.0645 0.3161 0.8001
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0065 0.0226
Schistosoma mansoni hypothetical protein 0.0172 0.0789 0.0789
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0043 0.0149
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0004 0.0013
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.007 0.051
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0381 0.0377
Loa Loa (eye worm) diacylglycerol kinase 2 0.0068 0.0267 0.0302
Echinococcus granulosus cpg binding protein 0.0151 0.0682 0.0678
Echinococcus multilocularis ferritin 0.0025 0.0053 0.0049
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0002
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.0043 0.0492
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0462 0.0458
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0085 0.0189
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0051 0.0176
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0279 0.3257
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0232 0.0806
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0075 0.0072
Brugia malayi 6-phosphofructokinase 0.0107 0.0462 0.1161
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0085 0.0189
Echinococcus granulosus neuropeptide receptor A26 0.0907 0.4478 0.4476
Trypanosoma brucei heat shock protein, putative 0.0032 0.0083 0.0288
Loa Loa (eye worm) endoplasmin 0.0032 0.0083 0.0091
Brugia malayi 6-phosphofructokinase 0.0107 0.0462 0.1161
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0045 0.0149 0.0145
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0198 0.0198
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.025 0.0246
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0167 0.0763 0.1911
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0039 0.0134
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0052 0.0186 0.0183
Mycobacterium ulcerans hypothetical protein 0.0311 0.1484 0.1699
Schistosoma mansoni hypothetical protein 0.002 0.0026 0.0026
Schistosoma mansoni cpg binding protein 0.0151 0.0682 0.0682
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0279 0.0968
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0083 0.0288
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0087 0.0645
Brugia malayi beta-lactamase family protein 0.0071 0.0279 0.0699
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0381 0.0377
Echinococcus granulosus snurportin 1 0.0299 0.1424 0.1421
Brugia malayi hypothetical protein 0.0107 0.0462 0.1162
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0046 0.0032
Brugia malayi Pre-SET motif family protein 0.0032 0.0087 0.0212
Schistosoma mansoni DNA polymerase eta 0.0077 0.0312 0.0312
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0279 0.0315
Trichomonas vaginalis diacylglycerol kinase, putative 0.0068 0.0267 0.065
Echinococcus multilocularis neuropeptide receptor A26 0.0907 0.4478 0.4476
Loa Loa (eye worm) hypothetical protein 0.0068 0.0267 0.0302
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0018 0.0017 0.0015
Echinococcus multilocularis alkaline phosphatase 0.016 0.0726 0.0723
Brugia malayi nuclear receptor RXR 0.0016 0.0004 0.0002
Brugia malayi hypothetical protein 0.0016 0.0004 0.0002
Echinococcus granulosus endoplasmin 0.0025 0.0051 0.0047
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0167 0.0763 0.1911
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0137 0.0474
Trichomonas vaginalis ferritin, putative 0.0025 0.0053 0.0106
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0279 0.0276
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0005 0.0012
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0108 0.0376
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0083 0.0341 0.1181
Schistosoma mansoni diacylglycerol kinase theta 0.0068 0.0267 0.0267
Entamoeba histolytica deoxycytidyl transferase, putative 0.0052 0.0186 0.0194
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0028 0.0028
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0005 0.0021
Trypanosoma brucei Sphingosine kinase 0.0068 0.0267 0.0924
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0083 0.0341 0.1181
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0013
Schistosoma mansoni DNA helicase recq5 0.0018 0.0017 0.0017
Leishmania major phosphoglycerate kinase B, cytosolic 0.0167 0.0763 0.2646
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0966 0.1106
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0006 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0075 0.0182
Chlamydia trachomatis phosphoglycerate kinase 0.0167 0.0763 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0198 0.0195
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0018 0.0017 0.0174
Mycobacterium tuberculosis Conserved protein 0.175 0.8706 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0075 0.0075
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0004 0.0001
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0044 0.0031
Schistosoma mansoni endoplasmin 0.0032 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0204 0.0949 0.1086
Mycobacterium ulcerans hypothetical protein 0.0071 0.0279 0.0314
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0045 0.0149 0.0145
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.007 0.0731
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0204 0.0949 0.2395
Echinococcus multilocularis heat shock protein 0.0032 0.0083 0.0079
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0083 0.0288
Echinococcus granulosus Diacylglycerol kinase theta 0.0068 0.0267 0.0263
Brugia malayi ImpB/MucB/SamB family protein 0.0052 0.0186 0.0462
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0279 0.0682
Onchocerca volvulus 0.0141 0.0632 0.5523
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0051 0.0176
Schistosoma mansoni Smad4 0.0016 0.0006 0.0006
Brugia malayi isocitrate dehydrogenase 0.0016 0.0005 0.0004
Entamoeba histolytica hypothetical protein 0.0107 0.0462 0.0512
Mycobacterium tuberculosis Conserved protein 0.0071 0.0279 0.0315
Echinococcus granulosus expressed protein 0.0033 0.0089 0.0086
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0279 0.0317
Giardia lamblia Grp94/Hsp90 0.0025 0.0051 0.0593
Entamoeba histolytica diacylglycerol kinase, putative 0.0068 0.0267 0.0287
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0083 0.1019
Schistosoma mansoni hypothetical protein 0.0204 0.0949 0.0949
Schistosoma mansoni ran 0.0021 0.0028 0.0028
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0075 0.0072
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0186
Loa Loa (eye worm) beta-lactamase 0.0071 0.0279 0.0317
Echinococcus granulosus expressed protein 0.0025 0.0053 0.0049
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0043 0.01
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0066 0.0063
Schistosoma mansoni ferritin 0.0025 0.0053 0.0053
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0165 0.0161
Echinococcus multilocularis dna polymerase eta 0.0077 0.0312 0.0308
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0279 0.0682
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0068 0.0267 0.0263
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0004 0.0001
Onchocerca volvulus 0.0071 0.0279 0.2201
Onchocerca volvulus 0.0032 0.0087 0.0391
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0317 0.11
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0462 0.1601
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0645 0.3161 0.8001
Brugia malayi steroid hormone receptor 0.003 0.0075 0.0182
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0036 0.0106 0.0106
Mycobacterium tuberculosis Conserved hypothetical protein 0.0052 0.0186 0.0208
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0462 0.0524
Entamoeba histolytica hypothetical protein 0.0107 0.0462 0.0512
Echinococcus multilocularis heat shock protein 90 0.0032 0.0083 0.0079
Schistosoma mansoni rotamase 0.0033 0.0089 0.0089
Brugia malayi Smad1 0.0016 0.0006 0.0005
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0083 0.0288
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0317 0.11
Mycobacterium ulcerans DNA polymerase IV 0.0078 0.0317 0.0358
Echinococcus granulosus lysine specific demethylase 5A 0.0069 0.0271 0.0267
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0046 0.0046
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0046 0.0046
Trypanosoma brucei mitochondrial DNA polymerase beta 0.059 0.2885 1
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0279 0.0314
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0452 0.2191 0.2512
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0312 0.1081
Loa Loa (eye worm) hypothetical protein 0.0441 0.2137 0.2452
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0015 0.0011
Echinococcus granulosus Smad4 0.0016 0.0006 0.0002
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0108 0.081
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0044 0.0152
Echinococcus granulosus sphingosine kinase 1 0.175 0.8706 0.8705
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0075 0.0072
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0108 0.138
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0075 0.0072
Echinococcus granulosus geminin 0.0172 0.0789 0.0786
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.016 0.0726 0.0723
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0025 0.0053 0.0025
Leishmania major heat shock protein 83-1 0.0032 0.0083 0.0288
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0317 0.11
Leishmania major heat shock protein 83-1 0.0032 0.0083 0.0288
Plasmodium falciparum phosphoglycerate kinase 0.0167 0.0763 1
Plasmodium vivax diacylglycerol kinase, putative 0.0068 0.0267 0.3462
Trichomonas vaginalis diacylglycerol kinase, putative 0.0068 0.0267 0.065
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0204 0.0949 0.0945
Plasmodium falciparum zinc finger protein, putative 0.0019 0.0017 0.0182
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0028 0.0097
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0083 0.0612
Trichomonas vaginalis heat shock protein, putative 0.0019 0.0022 0.0028
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.3857 0.3854
Brugia malayi Importin beta-1 subunit 0.0028 0.0065 0.0156
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0083
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0005 0.0004
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0078 0.0317 0.0778
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0085 0.0078
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.0121 0.1544
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0048
Leishmania major hypothetical protein, conserved 0.0068 0.0267 0.0924
Schistosoma mansoni hypothetical protein 0.0083 0.0341 0.0341
Echinococcus granulosus Diacylglycerol kinase zeta 0.0068 0.0267 0.0263
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0028 0.0024
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0462 0.0527
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0046 0.0046
Echinococcus granulosus FTZ F1 alpha 0.003 0.0075 0.0072
Onchocerca volvulus 0.0068 0.0267 0.2082
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.025 0.0624
Loa Loa (eye worm) hypothetical protein 0.0167 0.0763 0.0873
Schistosoma mansoni cpg binding protein 0.0141 0.0632 0.0632
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0279 0.0315
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0075 0.0072
Loa Loa (eye worm) CXXC zinc finger family protein 0.0141 0.0632 0.0722
Mycobacterium ulcerans lipase LipD 0.0071 0.0279 0.0314
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0167 0.0763 0.5862
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0089 0.0098
Leishmania major heat shock protein 83-1 0.0032 0.0083 0.0288
Leishmania major heat shock protein 83-1 0.0032 0.0083 0.0288
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0113 0.0109
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.007 0.0731
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0043 0.0149
Toxoplasma gondii hypothetical protein 0.0095 0.0402 0.3074
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0051 0.0102
Plasmodium vivax SET domain protein, putative 0.0032 0.0087 0.1099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0279 0.0279
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0075 0.028
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0075 0.0075
Schistosoma mansoni heat shock protein 0.0032 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.0068 0.0267 0.0267
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0075 0.0182
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0068 0.0267 0.0924
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0075 0.0182
Schistosoma mansoni nuclear hormone receptor 0.003 0.0075 0.0075
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0004 0.0004
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0165 0.0161
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.001 0.0006
Trypanosoma brucei phosphoglycerate kinase 0.0167 0.0763 0.2646
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0059 0.0219 0.0245
Loa Loa (eye worm) acetyltransferase 0.0145 0.0653 0.0746
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0108 0.0105
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0002
Schistosoma mansoni apoferritin-2 0.0025 0.0053 0.0053
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0171 0.0168
Loa Loa (eye worm) hypothetical protein 0.0053 0.0193 0.0217
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0015 0.015
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0147 0.0143
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0006 0.0003
Brugia malayi nuclear receptor NHR-88 0.003 0.0075 0.0182
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0043 0.0043
Mycobacterium ulcerans hypothetical protein 0.175 0.8706 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0015 0.015
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0046 0.0046
Brugia malayi Phosphoglycerate kinase 0.0061 0.0232 0.058
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0075 0.0083
Schistosoma mansoni DNA helicase recq1 0.0018 0.0017 0.0017
Trichomonas vaginalis sphingosine kinase, putative 0.0068 0.0267 0.065
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0279 0.0315
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0046 0.0046
Brugia malayi Latrophilin receptor protein 2 0.0204 0.0949 0.2395
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0102 0.0098
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.007 0.006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0085 0.0189
Plasmodium vivax diacylglycerol kinase, putative 0.0068 0.0267 0.3462
Echinococcus multilocularis GPCR, family 2 0.0204 0.0949 0.0945
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0381 0.0381
Schistosoma mansoni hypothetical protein 0.0441 0.2137 0.2137
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0085 0.0189
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0017 0.0033
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0102 0.0098
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0043 0.0029
Echinococcus multilocularis snurportin 1 0.0299 0.1424 0.1421
Brugia malayi Phosphoglycerate kinase 0.0167 0.0763 0.1925
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0043 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0317 0.11
Loa Loa (eye worm) hypothetical protein 0.0069 0.0273 0.031
Brugia malayi phosphofructokinase 0.0107 0.0462 0.1161
Onchocerca volvulus Huntingtin homolog 0.0119 0.0522 0.4482
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0101 0.0432 0.1497
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.025 0.0866
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0004 0.0002
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0462 0.0462
Brugia malayi heat shock protein 90 0.0032 0.0083 0.0201
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0167 0.0763 0.2646
Leishmania major importin beta-1 subunit, putative 0.0023 0.0039 0.0134
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.007 0.015
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0279 0.0315
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0018 0.0017 0.0013
Toxoplasma gondii histone lysine methyltransferase SET1 0.0274 0.1299 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0267 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0075 0.0182
Brugia malayi Bromodomain containing protein 0.0041 0.0131 0.0322
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0006 0.002
Schistosoma mansoni coup transcription factor 0.003 0.0075 0.0075
Schistosoma mansoni glutaminase 0.0802 0.395 0.395
Leishmania major heat shock protein 83-1 0.0032 0.0083 0.0288
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0009 0.0005
Trypanosoma brucei phosphoglycerate kinase, putative 0.0061 0.0232 0.0806
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.0462 0.0459
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0317 0.11
Trypanosoma brucei hypothetical protein, conserved 0.0068 0.0267 0.0924
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0083 0.0288
Loa Loa (eye worm) hypothetical protein 0.0071 0.0279 0.0317
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0051 0.0593
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.001 0.0006
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0462 0.0525
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0085 0.0296
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0006 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0317 0.11
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0025 0.0051 0.0071
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0271 0.0271
Schistosoma mansoni phosphoglycerate kinase 0.0167 0.0763 0.0763
Schistosoma mansoni phosphoglycerate kinase 0.0167 0.0763 0.0763
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0083
Onchocerca volvulus 0.0236 0.1107 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0462 0.577
Trichomonas vaginalis set domain proteins, putative 0.0236 0.1107 0.2784
Brugia malayi CXXC zinc finger family protein 0.0141 0.0632 0.1592
Leishmania major heat shock protein 83-1 0.0032 0.0083 0.0288
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0085 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0075 0.0182
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0075 0.0182
Loa Loa (eye worm) hypothetical protein 0.0645 0.3161 0.3628
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0075 0.028
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0043 0.0519
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0204 0.0949 0.0945
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0085 0.0189
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0108 0.0376
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0075 0.0182
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0165 0.0165
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0026 0.0053 0.005
Onchocerca volvulus Huntingtin homolog 0.0119 0.0522 0.4482
Brugia malayi hypothetical protein 0.0119 0.0522 0.1312
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0017 0.0102
Leishmania major heat shock protein 83-1 0.0032 0.0083 0.0288
Brugia malayi Pre-SET motif family protein 0.0207 0.0966 0.2438
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0232 0.0806
Brugia malayi ecdysteroid receptor 0.003 0.0075 0.0182
Trypanosoma brucei DNA polymerase IV, putative 0.0072 0.0285 0.0987
Brugia malayi jmjC domain containing protein 0.0069 0.0271 0.0677
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0147 0.1106
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0051 0.0052
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0046 0.0046
Brugia malayi glutaminase DH11.1 0.0802 0.395 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0071 0.0279 0.0317
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0083 0.0288
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0075 0.0083
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0065 0.0226
Leishmania major DNA polymerase eta, putative 0.0041 0.0131 0.0455
Brugia malayi MH1 domain containing protein 0.0016 0.0006 0.0005
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0232 0.0806
Loa Loa (eye worm) Smad1 0.0016 0.0006 0.0003
Brugia malayi PHD-finger family protein 0.0036 0.0105 0.0257
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0083 0.0341 0.1181
Mycobacterium ulcerans phosphoglycerate kinase 0.0167 0.0763 0.0871
Schistosoma mansoni heat shock protein 0.0032 0.0083 0.0083
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0462 0.0458
Leishmania major heat shock protein 83-1 0.0032 0.0083 0.0288
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0381 0.0377
Echinococcus granulosus neuropeptide s receptor 0.0907 0.4478 0.4476
Echinococcus granulosus ceramide kinase 0.0068 0.0267 0.0263
Plasmodium falciparum diacylglycerol kinase, putative 0.0068 0.0267 0.3462
Echinococcus multilocularis heat shock protein 90 0.0025 0.0051 0.0047
Loa Loa (eye worm) hypothetical protein 0.0055 0.0198 0.0224
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0462 0.0512
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0043 0.0519
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0085 0.0189
Echinococcus multilocularis zinc finger protein 0.0031 0.0079 0.0075
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0147 0.1106
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.025 0.025
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.001 0.0006
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0131 0.0455
Echinococcus multilocularis phosphoglycerate kinase 1 0.0167 0.0763 0.076
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0075 0.0072
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0279 0.0699
Loa Loa (eye worm) glutaminase 0.0802 0.395 0.4535
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0006 0.002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0046 0.0032
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.0312 0.0781
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0061 0.0232 0.0806
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0006 0.002
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0165 0.1125
Entamoeba histolytica diacylglycerol kinase, putative 0.0068 0.0267 0.0287
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0004 0.0000097187
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0462 0.1146
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0051 0.0052
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.0621 0.0618
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.0653 0.0649
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.025 0.0866
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0006 0.002
Brugia malayi Bromodomain containing protein 0.0085 0.0352 0.0883
Echinococcus multilocularis expressed protein 0.0025 0.0053 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0085 0.0189
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0028 0.0188
Leishmania major heat shock protein 83-1 0.0032 0.0083 0.0288
Brugia malayi Diacylglycerol kinase protein 2 0.0068 0.0267 0.0666
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0074 0.0542
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0018 0.0017 0.0013
Schistosoma mansoni sphingoid long chain base kinase 0.175 0.8706 0.8706
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0046 0.0158
Brugia malayi MH1 domain containing protein 0.0016 0.0006 0.0005
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0167 0.0763 1
Trypanosoma cruzi Sphingosine kinase 0.0068 0.0267 0.0924
Schistosoma mansoni zinc finger protein 0.0031 0.0079 0.0079
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0006 0.002
Echinococcus multilocularis smad 0.0016 0.0006 0.0002
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0075 0.0072
Plasmodium vivax phosphoglycerate kinase, putative 0.0167 0.0763 1
Echinococcus multilocularis dna polymerase kappa 0.0078 0.0317 0.0314
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0046 0.0158
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.0317 0.11
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0108 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0317 0.11
Loa Loa (eye worm) latrophilin receptor protein 2 0.0204 0.0949 0.1086
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0083
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0005 0.0002
Leishmania major heat shock protein 83-1 0.0032 0.0083 0.0288
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0068 0.0267 0.2029
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0036 0.0106 0.0102
Plasmodium vivax DNA repair protein REV1, putative 0.0016 0.0006 0.0028
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0083
Trypanosoma cruzi diacylglycerol kinase, putative 0.0068 0.0267 0.0924
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0462 0.0527
Echinococcus granulosus smad 0.0016 0.0006 0.0002
Schistosoma mansoni bromodomain containing protein 0.0074 0.0294 0.0294
Trypanosoma brucei unspecified product 0.0036 0.0105 0.0364
Echinococcus multilocularis intestinal type alkaline phosphatase 0.016 0.0726 0.0723
Treponema pallidum bacterioferrin (TpF1) 0.0025 0.0053 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0137 0.0474
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0028 0.0062
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0171 0.0171
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0381 0.0377
Brugia malayi Eye-specific diacylglycerol kinase 0.0068 0.0267 0.0666
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0137 0.0477
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0279 0.0968
Schistosoma mansoni diacylglycerol kinase theta 0.0068 0.0267 0.0267
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0036 0.0106 0.0102
Trichomonas vaginalis sphingosine kinase, putative 0.0068 0.0267 0.065
Schistosoma mansoni myst-related protein 0.0019 0.0017 0.0017
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0279 0.0315
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0068 0.0267 0.065
Echinococcus granulosus bloom syndrome protein 0.0045 0.0148 0.0144
Mycobacterium tuberculosis Diacylglycerol kinase 0.0068 0.0267 0.03
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0051 0.0176
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0462 0.1146
Entamoeba histolytica diacylglycerol kinase, putative 0.0068 0.0267 0.0287
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0075 0.0083
Schistosoma mansoni hypothetical protein 0.2007 1 1
Brugia malayi hypothetical protein 0.0068 0.0267 0.0666
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0165 0.0161
Echinococcus granulosus zinc finger protein 0.0031 0.0079 0.0075
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0085 0.0189
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0018 0.0017 0.0013
Echinococcus granulosus GPCR family 2 0.0204 0.0949 0.0945
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0462 0.0512
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0381 0.0381
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0075 0.0083
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0004 0.0013
Brugia malayi mbt repeat family protein 0.0048 0.0165 0.0409
Brugia malayi polk-prov protein 0.0042 0.0137 0.0337
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0075 0.0182
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.0462 0.0459
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0046 0.0046
Giardia lamblia DINP protein human, muc B family 0.0059 0.0219 0.281
Schistosoma mansoni myst-related protein 0.0019 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0085 0.0189
Schistosoma mansoni ap endonuclease 0.0037 0.0108 0.0108
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0042 0.0137 0.0153
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0075 0.0075
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.0312 0.1081
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0068 0.0267 0.065
Giardia lamblia Phosphoglycerate kinase 0.0167 0.0763 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0075 0.0182
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0006 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0013
Brugia malayi diacylglycerol kinase 0.0068 0.0267 0.0666
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0018 0.0063
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0076 0.0948
Schistosoma mansoni mixed-lineage leukemia protein mll 0.03 0.1431 0.1431
Echinococcus multilocularis bloom syndrome protein 0.0045 0.0148 0.0144
Schistosoma mansoni importin beta-1 0.0028 0.0065 0.0065
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0204 0.0949 0.0945
Trypanosoma cruzi Sphingosine kinase 0.0068 0.0267 0.0924
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0198 0.0195
Leishmania major heat shock protein 83-1 0.0032 0.0083 0.0288
Leishmania major phosphoglycerate kinase C, glycosomal 0.0167 0.0763 0.2646
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0232 0.0806
Brugia malayi MH2 domain containing protein 0.0016 0.0006 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0087 0.0087
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.025 0.0268
Schistosoma mansoni ferritin light chain 0.0025 0.0053 0.0053
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0075 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0075 0.0182
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0002
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0118 0.0115
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.007 0.087
Schistosoma mansoni smad 0.0016 0.0006 0.0006
Leishmania major diacylglycerol kinase-like protein 0.0068 0.0267 0.0924
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0013
Brugia malayi F/Y-rich N-terminus family protein 0.0046 0.0156 0.0385
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0075 0.0182
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0046 0.0046
Trypanosoma brucei heat shock protein, putative 0.0032 0.0083 0.0288
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0048
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0147 0.0346
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0025 0.0053 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0317 0.11
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0043 0.0039
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0462 0.1601
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0075 0.0075
Echinococcus granulosus fetal alzheimer antigen falz 0.003 0.0076 0.0072
Loa Loa (eye worm) histone methyltransferase 0.0045 0.0149 0.0167
Schistosoma mansoni hypothetical protein 0.0204 0.0949 0.0949
Entamoeba histolytica hypothetical protein 0.0107 0.0462 0.0512
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.007 0.0267
Echinococcus multilocularis sphingosine kinase 1 0.175 0.8706 0.8705
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.007 0.051
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0046 0.0158
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.016 0.0726 0.0723
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0016 0.0006 0.0016
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0068 0.0267 0.0263
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0462 0.0462
Schistosoma mansoni smad1 5 8 and 0.0016 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0049 0.0171 0.0193
Mycobacterium ulcerans hypothetical protein 0.0024 0.0046 0.0046
Echinococcus granulosus phosphoglycerate kinase 1 0.0167 0.0763 0.076
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0005 0.0005
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.016 0.0726 0.0723
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0279 0.1325 0.4595
Loa Loa (eye worm) hypothetical protein 0.0077 0.0312 0.0354
Leishmania major heat shock protein 83-1 0.0032 0.0083 0.0288
Leishmania major mitochondrial DNA polymerase beta 0.059 0.2885 1
Schistosoma mansoni hypothetical protein 0.0299 0.1424 0.1424
Schistosoma mansoni ferritin 0.0025 0.0053 0.0053
Schistosoma mansoni ran 0.0021 0.0028 0.0028
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0271 0.0307
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0113 0.0109
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0317 0.11
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0279 0.0314
Loa Loa (eye worm) hypothetical protein 0.0119 0.0522 0.0595
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.016 0.0726 0.0723
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0085 0.0189
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.007 0.015
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0165 0.0165
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0075 0.0072
Onchocerca volvulus 0.003 0.0075 0.028
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0167 0.0763 0.0871
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0013
Trypanosoma brucei heat shock protein, putative 0.0032 0.0083 0.0288
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0065 0.0474
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0004 0.0004
Loa Loa (eye worm) ceramide kinase 0.0068 0.0267 0.0302
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0083
Mycobacterium ulcerans bacterioferritin BfrA 0.0025 0.0053 0.0054
Trichomonas vaginalis helicase, putative 0.0032 0.0085 0.0189
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0317 0.11
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.007 0.015
Loa Loa (eye worm) hypothetical protein 0.0071 0.0279 0.0317
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0031 0.0031
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0075 0.0075
Trichomonas vaginalis rotamase, putative 0.0033 0.0089 0.02
Leishmania major hypothetical protein, conserved 0.0016 0.0004 0.0013
Brugia malayi beta-lactamase family protein 0.0071 0.0279 0.0699
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0167 0.0763 0.5862
Schistosoma mansoni endoplasmin 0.0032 0.0083 0.0083
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0046 0.0106
Mycobacterium ulcerans bacterioferritin BfrB 0.0025 0.0053 0.0054
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.1116 0.1278
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0028 0.0097
Trichomonas vaginalis ran, putative 0.0021 0.0028 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0219 0.0758
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0083
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0271 0.0271
Leishmania major DNA polymerase kappa, putative 0.0016 0.0006 0.002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0075 0.0182

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.9 nM Inhibitory activity of the compound against I-labeled ET-1 binding to Endothelin A receptor ChEMBL. 12372497
IC50 (binding) = 1.9 nM Inhibitory activity of the compound against I-labeled ET-1 binding to Endothelin A receptor ChEMBL. 12372497
IC50 (binding) = 9.1 nM Inhibitory activity of the compound against I-labeled ET-1 binding to Endothelin B receptor ChEMBL. 12372497
IC50 (binding) = 9.1 nM Inhibitory activity of the compound against I-labeled ET-1 binding to Endothelin B receptor ChEMBL. 12372497
Ratio (binding) = 4.8 Selectivity of the compound was calculated as the ratio of IC50 of Endothelin B receptor / IC50 of Endothelin A receptor ChEMBL. 12372497
Ratio (binding) = 4.8 Selectivity of the compound was calculated as the ratio of IC50 of Endothelin B receptor / IC50 of Endothelin A receptor ChEMBL. 12372497

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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