Detailed information for compound 1730210

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 309.788 | Formula: C16H20ClNO3
  • H donors: 1 H acceptors: 1 LogP: 4.76 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCNc1ccc2c(c1)c(=O)oc(c2Cl)OC
  • InChi: 1S/C16H20ClNO3/c1-3-4-5-6-9-18-11-7-8-12-13(10-11)15(19)21-16(20-2)14(12)17/h7-8,10,18H,3-6,9H2,1-2H3
  • InChiKey: GDSQFSKTUVPGRX-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0044 0.0409 0.0606
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0177 0.2223 0.3446
Trypanosoma cruzi hexose transporter, putative 0.0045 0.0417 0.4178
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0044 0.041 0.0719
Leishmania major hypothetical protein, conserved 0.002 0.0084 0.0841
Loa Loa (eye worm) hypothetical protein 0.0124 0.1501 0.2315
Echinococcus granulosus netrin receptor unc 5 0.0032 0.0245 0.0349
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.002 0.0084 0.0841
Giardia lamblia Prolyl-tRNA synthetase 0.0043 0.0397 1
Trypanosoma brucei glucose transporter, putative 0.0045 0.0417 0.4178
Echinococcus granulosus neuropeptide receptor A26 0.043 0.5664 0.8834
Chlamydia trachomatis lysine--tRNA ligase 0.0032 0.0246 0.9107
Trichomonas vaginalis glucose transporter, putative 0.002 0.0084 0.0054
Echinococcus multilocularis synaptic vesicle 2 protein 0.002 0.0084 0.0062
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.005 0.049 0.0469
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0032 0.0246 0.0703
Brugia malayi major facilitator superfamily protein 0.002 0.0084 0.0096
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0068 0.0156
Trypanosoma brucei glucose transporter, putative 0.0045 0.0417 0.4178
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0047 0.0448 0.4403
Schistosoma mansoni smad1 5 8 and 0.0016 0.0022 0.0064
Loa Loa (eye worm) hypothetical protein 0.0033 0.026 0.0373
Loa Loa (eye worm) hypothetical protein 0.0033 0.026 0.0373
Echinococcus multilocularis lysyl tRNA synthetase 0.0032 0.0246 0.0225
Schistosoma mansoni protein kinase 0.0044 0.0409 0.1167
Echinococcus multilocularis survival motor neuron protein 1 0.0485 0.6408 0.6401
Brugia malayi hypothetical protein 0.002 0.0084 0.0096
Leishmania major hypothetical protein, conserved 0.0033 0.026 0.2608
Mycobacterium ulcerans sugar transporter 0.002 0.0084 0.0693
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0044 0.0409 0.0388
Brugia malayi hypothetical protein 0.0124 0.1501 0.2315
Giardia lamblia Lysyl-tRNA synthetase 0.0032 0.0246 0.5722
Loa Loa (eye worm) hypothetical protein 0.0032 0.0246 0.035
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0068 0.0678
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0957 0.273
Brugia malayi isocitrate dehydrogenase 0.0016 0.0026 0.0006
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.0571 0.5653
Chlamydia trachomatis pyruvate kinase 0.0034 0.0269 1
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0269 0.0386
Brugia malayi cytochrome P450 0.0047 0.0448 0.0667
Trypanosoma brucei sugar transporter, putative 0.002 0.0084 0.0841
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.026 0.2608
Echinococcus granulosus pyruvate kinase 0.0017 0.0044 0.0035
Schistosoma mansoni smad 0.0016 0.0022 0.0064
Giardia lamblia Sugar-proton symporter 0.002 0.0084 0.1122
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0032 0.0246 0.2345
Schistosoma mansoni ap endonuclease 0.0019 0.0068 0.0193
Schistosoma mansoni hypothetical protein 0.0062 0.0648 0.1848
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.005 0.0495 0.4958
Leishmania major glucose transporter, lmgt3 0.0045 0.0417 0.4178
Toxoplasma gondii aldehyde dehydrogenase 0.0056 0.0571 0.1022
Loa Loa (eye worm) hypothetical protein 0.0035 0.0286 0.0414
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0068 0.0071
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.2684 0.4168
Brugia malayi Cam kinase protein 1 0.0044 0.0409 0.0606
Loa Loa (eye worm) hypothetical protein 0.0024 0.0129 0.0167
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0957 0.0937
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0047 0.0448 0.1579
Brugia malayi Pre-SET motif family protein 0.0211 0.2684 0.4168
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0269 0.0455
Onchocerca volvulus Huntingtin homolog 0.0124 0.1501 0.4724
Schistosoma mansoni glucose transport protein 0.0144 0.1772 0.5056
Echinococcus multilocularis pyruvate kinase 0.0034 0.0269 0.0247
Loa Loa (eye worm) hypothetical protein 0.0033 0.026 0.0373
Onchocerca volvulus 0.0033 0.026 0.0588
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0021 0.0091 0.0069
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0033 0.026 0.0876
Leishmania major glucose transporter, lmgt2 0.0045 0.0417 0.4178
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.005 0.0495 0.4958
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.005 0.0495 0.4958
Loa Loa (eye worm) hypothetical protein 0.0062 0.0648 0.0979
Leishmania major pyruvate kinase 0.0034 0.0269 0.2693
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0032 0.0245 0.0349
Toxoplasma gondii sugar transporter ST3 0.002 0.0084 0.0108
Trypanosoma brucei glucose transporter 1E 0.0045 0.0417 0.4178
Brugia malayi Latrophilin receptor protein 2 0.0029 0.0196 0.0273
Trichomonas vaginalis sugar transport protein, putative 0.002 0.0084 0.0054
Schistosoma mansoni hypothetical protein 0.0029 0.0196 0.0561
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0027 0.018 0.155
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0047 0.0448 0.1579
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0047 0.0448 0.4492
Mycobacterium ulcerans integral membrane transport protein 0.002 0.0084 0.0693
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0029 0.0196 0.0273
Toxoplasma gondii cytochrome p450 superfamily protein 0.0047 0.0448 0.0792
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0068 0.0678
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0233 0.2982 0.3641
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0047 0.0448 0.1579
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0044 0.0407 0.1162
Plasmodium falciparum lysine--tRNA ligase 0.0032 0.0246 0.0271
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0177 0.2223 0.2206
Loa Loa (eye worm) cytochrome P450 family protein 0.0087 0.0998 0.1527
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0042 0.0383 0.0564
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0212 0.2699 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0068 0.0678
Mycobacterium leprae Probable lipase LipE 0.0033 0.026 0.4078
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0047 0.0448 0.4403
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.0096
Schistosoma mansoni sugar transporter 0.002 0.0084 0.0239
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0417 0.1159
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0144 0.1772 0.1754
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0131 0.4548
Trypanosoma cruzi hexose transporter 0.0045 0.0417 0.4178
Echinococcus granulosus SAM and MBT domain containing protein 0.0044 0.0407 0.0603
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0131 0.0129
Brugia malayi hypothetical protein 0.0485 0.6408 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0026 0.0261
Echinococcus multilocularis solute carrier family 22 0.002 0.0084 0.0062
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0269 0.2693
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Mycobacterium tuberculosis Conserved protein 0.0033 0.026 0.0876
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0383 0.0565
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0047 0.0448 0.4403
Echinococcus granulosus Sugar transporter ERD6 protein 0.002 0.0084 0.0097
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0026 0.0261
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0022 0.0064
Mycobacterium ulcerans hypothetical protein 0.0033 0.026 0.2489
Loa Loa (eye worm) hypothetical protein 0.0084 0.0957 0.1463
Loa Loa (eye worm) sugar transporter 0.0144 0.1772 0.274
Onchocerca volvulus 0.0241 0.3083 1
Echinococcus granulosus calcium dependent protein kinase 0.0041 0.0372 0.0548
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0047 0.0448 0.4403
Mycobacterium ulcerans beta-lactamase 0.0033 0.026 0.2489
Leishmania major myo-inositol/proton symporter (MIT) 0.002 0.0084 0.0841
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0006
Plasmodium falciparum calcium-dependent protein kinase 1 0.0044 0.041 0.0472
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0026 0.0261
Leishmania major cytochrome p450-like protein 0.0047 0.0448 0.4492
Loa Loa (eye worm) hypothetical protein 0.0033 0.026 0.0373
Mycobacterium ulcerans esterase/lipase LipP 0.0033 0.026 0.2489
Schistosoma mansoni hypothetical protein 0.0156 0.1938 0.5528
Echinococcus granulosus solute carrier family 22 0.002 0.0084 0.0097
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0047 0.0448 0.1579
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0269 0.4345
Toxoplasma gondii transporter, major facilitator family protein 0.002 0.0084 0.0108
Schistosoma mansoni protein kinase 0.0044 0.0409 0.1167
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Schistosoma mansoni netrin receptor unc5 0.0032 0.0245 0.0698
Schistosoma mansoni Smad4 0.0016 0.0022 0.0064
Schistosoma mansoni aldehyde dehydrogenase 0.0056 0.0571 0.1629
Loa Loa (eye worm) hypothetical protein 0.0035 0.029 0.0419
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Schistosoma mansoni myelin transcription factor 1 myt1 0.005 0.049 0.1399
Loa Loa (eye worm) CYP4Cod1 0.0087 0.0998 0.1527
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0417 0.1159
Brugia malayi Sugar transporter family protein 0.0144 0.1772 0.274
Entamoeba histolytica protein kinase, putative 0.0044 0.0409 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0033 0.026 0.2489
Leishmania major protein kinase, putative 0.0044 0.0409 0.4101
Echinococcus granulosus geminin 0.0156 0.1938 0.2999
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0044 0.0023
Toxoplasma gondii sugar transporter ST2 0.002 0.0084 0.0108
Mycobacterium leprae Conserved hypothetical protein 0.0047 0.0448 1
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Echinococcus granulosus pyruvate kinase 0.0034 0.0269 0.0386
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0047 0.0448 0.1579
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0033 0.026 0.0373
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0435 0.124
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0383 0.0361
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Plasmodium vivax hexose transporter 0.0144 0.1772 0.2151
Schistosoma mansoni sex comb on midleg homolog 0.0044 0.0407 0.1162
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0047 0.0448 0.4403
Onchocerca volvulus Huntingtin homolog 0.0124 0.1501 0.4724
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0044 0.0409 0.0606
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0131 0.1171
Giardia lamblia Hexose transporter 0.002 0.0084 0.1122
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0383 0.0565
Loa Loa (eye worm) MH2 domain-containing protein 0.0231 0.2958 0.4597
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.026 0.2608
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.1772 0.5655
Brugia malayi major facilitator superfamily protein 0.002 0.0084 0.0096
Onchocerca volvulus 0.0084 0.0957 0.291
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0044 0.041 0.0472
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0043 0.0397 0.1133
Mycobacterium leprae conserved hypothetical protein 0.0033 0.026 0.4078
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0047 0.0448 0.4403
Echinococcus multilocularis 0.0047 0.0448 0.0427
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.0096
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0435 0.124
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0131 0.1312
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.005 0.049 0.0733
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0269 0.0386
Echinococcus granulosus solute carrier family 22 0.002 0.0084 0.0097
Brugia malayi Pre-SET motif family protein 0.003 0.022 0.031
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0205 0.0287
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0269 0.0616
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0004
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0269 0.0299
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0026 0.0006
Plasmodium falciparum calcium-dependent protein kinase 5 0.0044 0.041 0.0472
Brugia malayi mbt repeat family protein 0.0044 0.0407 0.0603
Echinococcus multilocularis pyruvate kinase 0.0017 0.0044 0.0022
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.0096
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0032 0.0246 0.3633
Trypanosoma brucei glucose transporter, putative 0.0045 0.0417 0.4178
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0044 0.0407 0.1078
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.0096
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Echinococcus multilocularis pyruvate kinase 0.0017 0.0044 0.0022
Loa Loa (eye worm) hypothetical protein 0.0043 0.0397 0.0587
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0055 0.0558 0.0537
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0047 0.0448 0.4492
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.026 0.0639
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.1154 0.1772
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0043 0.0397 0.0376
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0047 0.0448 0.4403
Trichomonas vaginalis CAMK family protein kinase 0.0044 0.0409 0.1133
Schistosoma mansoni hypothetical protein 0.0272 0.3505 1
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0957 0.1463
Brugia malayi Cytochrome P450 family protein 0.0047 0.0448 0.0667
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0068 0.066
Echinococcus multilocularis netrin receptor unc 5 0.0032 0.0245 0.0223
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0269 0.0386
Echinococcus multilocularis Sugar transporter ERD6 protein 0.002 0.0084 0.0062
Trypanosoma brucei glucose transporter, putative 0.0045 0.0417 0.4178
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.002 0.0084 0.0216
Trichomonas vaginalis penicillin-binding protein, putative 0.0033 0.026 0.0639
Echinococcus granulosus solute carrier family 22 0.002 0.0084 0.0097
Plasmodium vivax sugar transporter, putative 0.002 0.0084 0.0071
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0047 0.0448 0.1579
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0026 0.0006
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Loa Loa (eye worm) hypothetical protein 0.005 0.049 0.0733
Schistosoma mansoni survival motor neuron protein 0.0099 0.1154 0.3293
Trypanosoma brucei THT1 - hexose transporter, putative 0.0045 0.0417 0.4178
Trichomonas vaginalis penicillin-binding protein, putative 0.0033 0.026 0.0639
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Schistosoma mansoni hypothetical protein 0.0144 0.1772 0.5056
Echinococcus granulosus General substrate transporter 0.0124 0.1496 0.2307
Schistosoma mansoni glucose transport protein 0.0144 0.1772 0.5056
Loa Loa (eye worm) follicle stimulating hormone receptor 0.047 0.6206 0.9683
Plasmodium vivax CDK-related protein kinase 6, putative 0.0612 0.8144 1
Mycobacterium tuberculosis Probable esterase LipL 0.0033 0.026 0.0876
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0043 0.0397 0.8387
Leishmania major glucose transporter, lmgt1 0.0045 0.0417 0.4178
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0043 0.0397 0.0587
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0144 0.1772 0.1754
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Echinococcus granulosus polycomb protein SCMH1 0.0044 0.0407 0.0603
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Trypanosoma cruzi cytochrome P450, putative 0.0087 0.0998 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0044 0.0409 0.0388
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0047 0.0448 0.4403
Trypanosoma brucei cytochrome P450, putative 0.0087 0.0998 1
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0029 0.0196 0.0175
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0131 0.0392
Echinococcus multilocularis pyruvate kinase 0.0027 0.0172 0.015
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0047 0.0448 0.4403
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Echinococcus granulosus GPCR family 2 0.0029 0.0196 0.0273
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0084 0.0054
Brugia malayi Major Facilitator Superfamily protein 0.002 0.0084 0.0096
Trypanosoma brucei THT1 - hexose transporter, putative 0.0045 0.0417 0.4178
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0044 0.041 0.0472
Loa Loa (eye worm) pigment dispersing factor receptor c 0.009 0.1036 0.1588
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0047 0.0448 0.4492
Trypanosoma cruzi glucose transporter, putative 0.002 0.0084 0.0841
Schistosoma mansoni hypothetical protein 0.0029 0.0196 0.0561
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0044 0.041 0.0719
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0646
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0383 0.1092
Toxoplasma gondii exonuclease III APE 0.0019 0.0068 0.0078
Leishmania major pyruvate kinase 0.0034 0.0269 0.2693
Schistosoma mansoni smad1 5 8 and 0.0016 0.0022 0.0064
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0269 0.0667
Loa Loa (eye worm) hypothetical protein 0.0033 0.026 0.0373
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.005 0.049 0.0733
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0144 0.1772 0.274
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0047 0.0448 0.4403
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0269 0.2693
Echinococcus granulosus beta LACTamase domain containing family member 0.0033 0.026 0.0373
Schistosoma mansoni sugar transporter 0.002 0.0084 0.0239
Toxoplasma gondii ABC1 family protein 0.0033 0.026 0.0439
Schistosoma mansoni glucose transport protein 0.0144 0.1772 0.5056
Brugia malayi follicle stimulating hormone receptor 0.047 0.6206 0.9683
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.0096
Entamoeba histolytica protein kinase, putative 0.0044 0.0409 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0026 0.0004
Loa Loa (eye worm) cytochrome P450 family protein 0.0158 0.1958 0.3032
Onchocerca volvulus 0.0099 0.1154 0.3568
Echinococcus multilocularis zinc finger protein 0.0018 0.0054 0.0032
Brugia malayi PHD-finger family protein 0.0023 0.0121 0.0154
Plasmodium falciparum proline--tRNA ligase 0.005 0.0495 0.0577
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0269 0.2575
Entamoeba histolytica hypothetical protein 0.0024 0.0131 0.1852
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.0571 0.5653
Echinococcus multilocularis Ankyrin 0.0032 0.0246 0.0225
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.0571 0.5653
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0068 0.0051
Loa Loa (eye worm) transcription factor SMAD2 0.0231 0.2958 0.4597
Mycobacterium ulcerans lipase LipD 0.0033 0.026 0.2489
Brugia malayi Cytochrome P450 family protein 0.0087 0.0998 0.1527
Trichomonas vaginalis esterase, putative 0.0033 0.026 0.0639
Loa Loa (eye worm) hypothetical protein 0.0065 0.0697 0.1056
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0068 0.0678
Brugia malayi Cytochrome P450 family protein 0.0158 0.1958 0.3032
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0044 0.0409 0.0388
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0047 0.0448 0.1579
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0129 0.0167
Mycobacterium tuberculosis Conserved protein 0.0033 0.026 0.0876
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.002 0.0084 0.0216
Plasmodium falciparum protein kinase 6 0.0612 0.8144 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0047 0.0448 0.4403
Loa Loa (eye worm) hypothetical protein 0.0032 0.0246 0.0351
Echinococcus multilocularis neuropeptide receptor A26 0.043 0.5664 0.5654
Loa Loa (eye worm) hypothetical protein 0.0044 0.0409 0.0606
Loa Loa (eye worm) latrophilin receptor protein 2 0.0029 0.0196 0.0273
Loa Loa (eye worm) hypothetical protein 0.0034 0.0269 0.0386
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0068 0.0071
Brugia malayi MH2 domain containing protein 0.0231 0.2958 0.4597
Trypanosoma brucei THT1 - hexose transporter, putative 0.0045 0.0417 0.4178
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0044 0.041 0.0472
Echinococcus granulosus fetal alzheimer antigen falz 0.0021 0.0091 0.0108
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0043 0.0397 0.1093
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0026 0.0004
Onchocerca volvulus 0.0033 0.026 0.0588
Loa Loa (eye worm) hypothetical protein 0.0044 0.0407 0.0603
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0033 0.026 0.0876
Mycobacterium leprae putative cytochrome p450 0.0047 0.0448 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0021 0.0091 0.026
Schistosoma mansoni pyruvate kinase 0.0017 0.0044 0.0126
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0131 1
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0047 0.0448 0.4403
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0269 0.0386
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.026 0.2608
Plasmodium falciparum calcium-dependent protein kinase 3 0.0044 0.041 0.0472
Brugia malayi mbt repeat family protein 0.0044 0.0407 0.0603
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0131 0.1171
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0047 0.0448 0.1579
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.002 0.0084 0.0693
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0033 0.0259 0.0372
Loa Loa (eye worm) hypothetical protein 0.004 0.0357 0.0524
Leishmania major cytochrome p450-like protein 0.0087 0.0998 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0044 0.0409 0.0606
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.0096
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.0096
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0269 0.0616
Loa Loa (eye worm) bromodomain containing protein 0.0016 0.003 0.0012
Echinococcus granulosus nuclear factor of activated T cells 5 0.0314 0.4082 0.6357
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0435 0.0413
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0056 0.0571 0.0859
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0044 0.0409 0.0606
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0269 0.0667
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0435 0.0646
Brugia malayi latrophilin 2 splice variant baaae 0.0062 0.0648 0.0979
Schistosoma mansoni hypothetical protein 0.0019 0.0067 0.0191
Onchocerca volvulus 0.0033 0.026 0.0588
Onchocerca volvulus 0.0044 0.0407 0.1078
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0042 0.0383 0.0564
Trypanosoma cruzi hexose transporter, putative 0.0045 0.0417 0.4178
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0047 0.0448 0.4492
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0026 0.0074
Schistosoma mansoni hypothetical protein 0.0029 0.0196 0.0561
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0068 0.0051
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0131 1
Echinococcus multilocularis GPCR, family 2 0.0029 0.0196 0.0175
Leishmania major glucose transporter/membrane transporter D2, putative 0.0045 0.0417 0.4178
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0047 0.0448 0.1579
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0417 0.1159
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0032 0.0246 0.0592
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0044 0.0023
Plasmodium falciparum hexose transporter 0.0144 0.1772 0.2151
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0047 0.0448 0.4403
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0047 0.0448 0.1579
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0131 0.0197
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0032 0.0246 0.2345
Plasmodium vivax calcium-dependent protein kinase, putative 0.0044 0.041 0.0472
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0033 0.026 0.0373
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0047 0.0448 0.4492
Schistosoma mansoni sex comb on midleg homolog 0.0044 0.0407 0.1162
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.002 0.0084 0.0693
Loa Loa (eye worm) hypothetical protein 0.009 0.1036 0.1588
Echinococcus granulosus pyruvate kinase 0.0017 0.0044 0.0035
Schistosoma mansoni hypothetical protein 0.0047 0.0448 0.1279
Leishmania major lysyl-tRNA synthetase, putative 0.0032 0.0246 0.2467
Trypanosoma brucei glucose transporter, putative 0.0045 0.0417 0.4178
Schistosoma mansoni pyruvate kinase 0.0034 0.0269 0.0767
Trypanosoma cruzi hexose transporter, putative 0.0045 0.0417 0.4178
Plasmodium vivax lysine--tRNA ligase, putative 0.0032 0.0246 0.0271
Schistosoma mansoni ap endonuclease 0.0019 0.0068 0.0193
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0245 0.0348
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0033 0.026 0.0743
Brugia malayi Death domain containing protein 0.0032 0.0245 0.0348
Loa Loa (eye worm) major facilitator superfamily transporter 0.002 0.0084 0.0096
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0269 0.2693
Schistosoma mansoni aldehyde dehydrogenase 0.0056 0.0571 0.1629
Echinococcus granulosus survival motor neuron protein 1 0.0485 0.6408 1
Echinococcus multilocularis pyruvate kinase 0.0034 0.0269 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0417 0.1159
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0047 0.0448 0.4403
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0068 0.0071
Echinococcus granulosus neuropeptide s receptor 0.043 0.5664 0.8834
Trypanosoma cruzi hexose transporter, putative 0.0024 0.0141 0.141
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Schistosoma mansoni glucose transporter 0.002 0.0084 0.0239
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0047 0.0448 0.1579
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0084 0.0054
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0957 0.1463
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0033 0.0259 0.0238
Mycobacterium tuberculosis Probable lipase LipE 0.0033 0.026 0.0876
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Loa Loa (eye worm) PHD-finger family protein 0.0019 0.0067 0.007
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.0096
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0032 0.0245 0.0223
Echinococcus multilocularis pyruvate kinase 0.0017 0.0044 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.026 0.0639
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0084 0.0054
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0087 0.0998 1
Echinococcus multilocularis polycomb protein SCMH1 0.0044 0.0407 0.0386
Brugia malayi Sugar transporter family protein 0.002 0.0084 0.0096
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0047 0.0448 0.1579
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0026 0.0261
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.002 0.0084 0.0071
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0047 0.0448 0.4403
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0032 0.0246 0.2467
Trypanosoma cruzi cytochrome P450, putative 0.0087 0.0998 1
Loa Loa (eye worm) hypothetical protein 0.0485 0.6408 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0044 0.0409 0.0606
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.0096
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0144 0.1772 0.274
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.0096
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0033 0.026 0.0743
Mycobacterium tuberculosis Probable hydrolase 0.0033 0.026 0.0876
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0131 0.0129
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0383 0.1092
Echinococcus multilocularis solute carrier family 22 0.002 0.0084 0.0062
Loa Loa (eye worm) hypothetical protein 0.0039 0.0344 0.0503
Loa Loa (eye worm) cytochrome P450 family protein 0.0087 0.0998 0.1527
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0047 0.0448 0.1579
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0029 0.0196 0.0273
Schistosoma mansoni sugar transporter 0.002 0.0084 0.0239
Echinococcus multilocularis General substrate transporter 0.0124 0.1496 0.1477
Toxoplasma gondii facilitative glucose transporter GT1 0.0144 0.1772 0.3275
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0068 0.0527
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0027 0.018 0.0576
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0047 0.0448 0.4403
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0245 0.0348
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0047 0.0448 0.4403
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Echinococcus multilocularis beta LACTamase domain containing family member 0.0033 0.026 0.0239
Echinococcus multilocularis geminin 0.0156 0.1938 0.192
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0043 0.0397 0.0587
Trypanosoma brucei glucose transporter, putative 0.0045 0.0417 0.4178
Loa Loa (eye worm) hypothetical protein 0.0124 0.1501 0.2315
Trypanosoma brucei glucose transporter, putative 0.0045 0.0417 0.4178
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0047 0.0448 0.1579
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0068 0.45
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0131 0.0197
Onchocerca volvulus Netrin receptor homolog 0.0032 0.0245 0.0537
Echinococcus multilocularis calcium dependent protein kinase 0.0041 0.0372 0.0351
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.002 0.0084 0.0239
Echinococcus multilocularis solute carrier family 22 0.002 0.0084 0.0062
Echinococcus granulosus solute carrier family 22 0.002 0.0084 0.0097
Plasmodium falciparum calcium-dependent protein kinase 4 0.0044 0.041 0.0472
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0043 0.0397 0.1133
Toxoplasma gondii lysine-tRNA ligase 0.0032 0.0246 0.0413
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0269 0.0908
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0383 0.0361
Schistosoma mansoni sugar transporter 0.002 0.0084 0.0239
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0047 0.0448 0.1579
Echinococcus multilocularis SAM and MBT domain containing protein 0.0044 0.0407 0.0386
Loa Loa (eye worm) hypothetical protein 0.0043 0.0397 0.0587
Echinococcus granulosus pyruvate kinase 0.0017 0.0044 0.0035
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0044 0.0034
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0269 0.2693
Schistosoma mansoni protein kinase 0.0044 0.0409 0.1167
Schistosoma mansoni pyruvate kinase 0.0034 0.0269 0.0767
Onchocerca volvulus 0.003 0.022 0.0455
Brugia malayi Sugar transporter family protein 0.002 0.0084 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0084 0.0054
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0144 0.1772 0.274
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0144 0.1772 0.274
Echinococcus multilocularis histone acetyltransferase MYST2 0.005 0.049 0.0469
Plasmodium falciparum pyruvate kinase 0.0034 0.0269 0.0299
Trichomonas vaginalis glucose transporter, putative 0.0045 0.0417 0.1159
Loa Loa (eye worm) mbt repeat family protein 0.0044 0.0407 0.0603
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0047 0.0448 0.4403
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0047 0.0448 0.1579
Brugia malayi Major Facilitator Superfamily protein 0.002 0.0084 0.0096
Plasmodium vivax SET domain protein, putative 0.003 0.022 0.0239
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0004
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0056 0.0571 0.2038
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0068 0.0046
Echinococcus granulosus lysyl tRNA synthetase 0.0032 0.0246 0.0351
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.005 0.0495 0.0879
Echinococcus granulosus cytochrome P450 2K1 0.0047 0.0448 0.0667
Trypanosoma cruzi hexose transporter, putative 0.002 0.0084 0.0841
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0047 0.0448 0.1579
Echinococcus granulosus histone acetyltransferase MYST2 0.005 0.049 0.0733
Brugia malayi beta-lactamase family protein 0.0033 0.026 0.0373
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0192 0.0413
Loa Loa (eye worm) sugar transporter 0.002 0.0084 0.0096
Entamoeba histolytica hypothetical protein 0.0032 0.0246 0.5227
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0029 0.0196 0.0273
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0047 0.0448 0.1579
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0047 0.0448 0.1579
Schistosoma mansoni zinc finger protein 0.0018 0.0054 0.0153
Echinococcus granulosus synaptic vesicle 2 protein 0.002 0.0084 0.0097
Schistosoma mansoni hypothetical protein 0.0032 0.0245 0.0698
Echinococcus granulosus zinc finger protein 0.0018 0.0054 0.005
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0027 0.018 0.0576
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.0096
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0029 0.0196 0.0175
Plasmodium vivax hypothetical protein, conserved 0.0033 0.026 0.0288
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.022 0.0628
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0144 0.1772 0.1754
Brugia malayi Bromodomain containing protein 0.0069 0.075 0.114
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0044 0.041 0.0719
Trichomonas vaginalis myo-inositol transporter, putative 0.002 0.0084 0.0054
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Plasmodium vivax proline--tRNA ligase, putative 0.005 0.0495 0.0577
Giardia lamblia Pyruvate kinase 0.0034 0.0269 0.6363
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0044 0.0409 0.0606
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0047 0.0448 0.4403
Schistosoma mansoni cytochrome P450 0.0047 0.0448 0.1279
Trypanosoma brucei glucose transporter, putative 0.0045 0.0417 0.4178
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0131 0.1312
Loa Loa (eye worm) hypothetical protein 0.0029 0.0196 0.0273
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0417 0.1159
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0129 0.1804
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0043 0.0397 0.9644
Trypanosoma cruzi sugar transporter, putative 0.002 0.0084 0.0841
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0383 0.1092
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0044 0.0409 0.4101
Schistosoma mansoni hypothetical protein 0.0156 0.1938 0.5528
Mycobacterium tuberculosis Conserved protein 0.0033 0.026 0.0876
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0084 0.0054
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0409 0.1167
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0032 0.0246 0.2467
Plasmodium falciparum protein kinase 7 0.0408 0.5357 0.6567
Loa Loa (eye worm) beta-lactamase 0.0033 0.026 0.0373
Brugia malayi Major Facilitator Superfamily protein 0.002 0.0084 0.0096
Trypanosoma brucei glucose transporter 2A 0.0045 0.0417 0.4178
Brugia malayi beta-lactamase family protein 0.0033 0.026 0.0373
Schistosoma mansoni hypothetical protein 0.0029 0.0196 0.0561
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.002 0.0084 0.2573
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0033 0.026 0.0876
Brugia malayi hypothetical protein 0.002 0.0084 0.0096
Echinococcus granulosus pyruvate kinase 0.0034 0.0269 0.0386
Echinococcus multilocularis neuropeptide s receptor 0.043 0.5664 0.5654
Plasmodium falciparum mitogen-activated protein kinase 2 0.0233 0.2982 0.3641
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0269 0.0616
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.009 0.1036 0.1588
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0144 0.1772 0.1754
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.022 0.0199
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.0096
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0047 0.0448 0.4403
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0269 0.0386
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.005 0.0495 0.4958
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0044 0.0409 0.0388
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0018 0.005 0.0043
Toxoplasma gondii protein kinase, putative 0.0408 0.5357 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.009 0.1036 0.1588
Brugia malayi beta-lactamase 0.0033 0.026 0.0373
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.0096
Toxoplasma gondii sugar transporter ST1 0.002 0.0084 0.0108
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0056 0.0571 0.5722
Schistosoma mansoni hypothetical protein 0.0099 0.1154 0.3293
Echinococcus granulosus Ankyrin 0.0032 0.0246 0.0351
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Brugia malayi lysyl-tRNA synthetase 0.0032 0.0246 0.035
Schistosoma mansoni lysyl-tRNA synthetase 0.0032 0.0246 0.0702
Plasmodium falciparum calcium-dependent protein kinase 2 0.0044 0.041 0.0472
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0047 0.0448 0.1579
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0314 0.4082 0.4069
Schistosoma mansoni ankyrin 23/unc44 0.0032 0.0245 0.0698
Loa Loa (eye worm) cytochrome P450 0.0047 0.0448 0.0667
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.005 0.0495 0.4958
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Loa Loa (eye worm) hypothetical protein 0.0032 0.0245 0.0348
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.026 0.0639
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0022 0.0063
Echinococcus granulosus death domain containing protein 0.0032 0.0245 0.0349
Brugia malayi Protein kinase domain containing protein 0.0035 0.0282 0.0407
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0233 0.2982 0.5544
Trichomonas vaginalis set domain proteins, putative 0.024 0.3081 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0055 0.0558 0.0839
Brugia malayi hypothetical protein 0.002 0.0084 0.0096
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0043 0.0397 0.0587
Leishmania major cytochrome p450-like protein 0.0047 0.0448 0.4492
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.022 0.0628
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0026 0.0261
Loa Loa (eye worm) hypothetical protein 0.0038 0.032 0.0466
Trichomonas vaginalis sugar transporter, putative 0.002 0.0084 0.0054
Brugia malayi Cytochrome P450 family protein 0.0087 0.0998 0.1527
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0056 0.0571 0.055
Loa Loa (eye worm) major facilitator superfamily transporter 0.002 0.0084 0.0096
Loa Loa (eye worm) MBCTL1 0.005 0.049 0.0733
Schistosoma mansoni smad1 5 8 and 0.0016 0.0022 0.0064
Brugia malayi Uncoordinated protein 44 0.0032 0.0245 0.0348
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0022 0.0063
Loa Loa (eye worm) hypothetical protein 0.0033 0.026 0.0373
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.022 0.0364
Schistosoma mansoni bromodomain containing protein 0.0058 0.0603 0.1721
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.0096
Schistosoma mansoni lysyl-tRNA synthetase 0.0032 0.0246 0.0702
Mycobacterium tuberculosis Probable lipase LipD 0.0033 0.026 0.0876
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0044 0.0409 0.0606
Brugia malayi Bromodomain containing protein 0.0035 0.0289 0.0418
Trichomonas vaginalis glucose transporter, putative 0.0045 0.0417 0.1159
Echinococcus multilocularis solute carrier family 22 0.002 0.0084 0.0062

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) > 50 % Inhibition of gamma-secretase-mediated betaAPP K670N/M671L mutant cleavage in HEK293 cells assessed as inhibition of amyloid beta40/42 production at 60 uM after 8 hrs by chemiluminescence assay relative to control ChEMBL. 23294826

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.