Detailed information for compound 1746017

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 806.837 | Formula: C35H46N6O14S
  • H donors: 12 H acceptors: 13 LogP: -0.51 Rotable bonds: 26
    Rule of 5 violations (Lipinski): 4
  • SMILES: CSCCC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)O)Cc1ccc(cc1)O)Cc1ccccc1)NC(=O)N[C@@H]1O[C@@H](C(=O)O)[C@H]([C@@H]([C@@H]1O)O)O
  • InChi: 1S/C35H46N6O14S/c1-56-13-5-8-21(40-35(54)41-32-28(47)26(45)27(46)29(55-32)34(52)53)31(49)39-22(14-18-6-3-2-4-7-18)30(48)37-16-24(43)36-17-25(44)38-23(33(50)51)15-19-9-11-20(42)12-10-19/h2-4,6-7,9-12,21-23,26-29,32,42,45-47H,5,8,13-17H2,1H3,(H,36,43)(H,37,48)(H,38,44)(H,39,49)(H,50,51)(H,52,53)(H2,40,41,54)/t21-,22-,23-,26-,27-,28-,29+,32+/m0/s1
  • InChiKey: IUOXNXMDEDZDOX-FHLKQELJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis 0.0012 0.0011 0.0011
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0047 0.0047
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0146 0.0424
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.007 0.0292
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0435 0.0435
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0074 0.0102
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0011
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0018 0.0074 0.0102
Loa Loa (eye worm) hypothetical protein 0.0036 0.0275 0.0275
Plasmodium falciparum JmjC domain-containing protein, putative 0.0033 0.0242 0.3084
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0534 0.1638
Echinococcus multilocularis jumonji domain containing 1A 0.0033 0.0242 0.0242
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0156 0.0455
Loa Loa (eye worm) beta-lactamase 0.0036 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0028 0.0187 0.0187
Schistosoma mansoni terminal deoxycytidyl transferase 0.0059 0.0534 0.0653
Onchocerca volvulus 0.0031 0.0219 0.1066
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0076 0.0076
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0751 0.4139
Echinococcus multilocularis musashi 0.0028 0.0193 0.0193
Mycobacterium tuberculosis Conserved protein 0.0036 0.0275 0.043
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0751 0.1206
Echinococcus granulosus apoptotic protease activating factor 1 0.0031 0.0219 0.0219
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0017 0.007 0.007
Echinococcus granulosus cpg binding protein 0.0095 0.0931 0.0931
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0608 0.0608
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.2051 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.3202 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0113 0.1136 0.1391
Schistosoma mansoni phosphatidylserine receptor 0.0033 0.0242 0.0296
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0076 0.0833
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.007 0.0292
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0534 0.1638
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0156 0.1923
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0076 0.032
Loa Loa (eye worm) acetyltransferase 0.0165 0.1708 0.1708
Leishmania major cathepsin L-like protease 0.0018 0.0076 0.0204
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.063 0.194
Schistosoma mansoni jumonji domain containing protein 0.0122 0.124 0.1518
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0076 0.0076
Loa Loa (eye worm) fli-1 protein 0.0237 0.2514 0.2514
Onchocerca volvulus Huntingtin homolog 0.0132 0.1347 0.657
Entamoeba histolytica metallo-beta-lactamase family protein 0.0017 0.007 0.0292
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0113 0.1136 0.1391
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0608 0.0973
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0435 0.2372
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.003 0.003
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0435 0.2079
Mycobacterium ulcerans hypothetical protein 0.0157 0.1629 0.2638
Loa Loa (eye worm) hypothetical protein 0.0025 0.0156 0.0156
Leishmania major hypothetical protein, conserved 0.0046 0.039 0.1188
Echinococcus granulosus jumonji domain containing 1A 0.0033 0.0242 0.0242
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0033 0.0242 0.1291
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0063 0.0077
Echinococcus multilocularis kelch ECH associated protein 1 0.0195 0.205 0.205
Echinococcus multilocularis zinc finger protein 0.0028 0.019 0.019
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0275 0.043
Trichomonas vaginalis helicase, putative 0.002 0.01 0.0437
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0059 0.0534 0.0534
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0005 0.0005
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0275 0.043
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0076 0.0093
Echinococcus granulosus expressed protein 0.0018 0.0074 0.0074
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.007 0.0097
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.004 0.0318 0.0318
Brugia malayi jmjC domain containing protein 0.0033 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0033 0.0242 0.0242
Schistosoma mansoni apoferritin-2 0.0018 0.0074 0.009
Entamoeba histolytica hypothetical protein, conserved 0.0017 0.007 0.0292
Echinococcus granulosus lysine specific demethylase 6a 0.0033 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0017 0.007 0.007
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1452 0.4515
Brugia malayi Cell death protein 3 precursor 0.0031 0.0219 0.0219
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0074 0.0102
Leishmania major hypothetical protein, conserved 0.0017 0.007 0.0186
Echinococcus multilocularis protein C ets 2 0.0011 0.0005 0.0005
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0068 0.0068
Onchocerca volvulus 0.0036 0.0275 0.134
Loa Loa (eye worm) hypothetical protein 0.0031 0.0219 0.0219
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0113 0.1136 0.5516
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0076 0.032
Brugia malayi isocitrate dehydrogenase 0.0017 0.0068 0.0068
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0017 0.007 0.0186
Brugia malayi jmjC domain containing protein 0.0033 0.0242 0.0242
Onchocerca volvulus 0.0012 0.0011 0.0052
Brugia malayi hypothetical protein 0.0144 0.1478 0.1478
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0751 0.1206
Onchocerca volvulus 0.0017 0.007 0.0343
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0315 0.3381 0.3381
Loa Loa (eye worm) hypothetical protein 0.0017 0.007 0.007
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0017 0.007 0.007
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0051 0.044 0.044
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0207 0.0614
Schistosoma mansoni survival motor neuron protein 0.01 0.0995 0.1218
Loa Loa (eye worm) fibroinase 0.0018 0.0076 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0892 0.1092
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0076 0.0833
Schistosoma mansoni cpg binding protein 0.0095 0.0931 0.1141
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0063 0.0063
Mycobacterium leprae Beta-lactamase-like protein 0.0017 0.007 0.0097
Echinococcus multilocularis cpg binding protein 0.0095 0.0931 0.0931
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0017 0.007 0.0186
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0181 0.0181
Echinococcus multilocularis snurportin 1 0.0315 0.3381 0.3381
Echinococcus granulosus caspase 2 0.0031 0.0219 0.0219
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0122 0.124 0.124
Echinococcus multilocularis dna polymerase kappa 0.0059 0.0534 0.0534
Brugia malayi jmjC domain containing protein 0.0033 0.0242 0.0242
Brugia malayi CXXC zinc finger family protein 0.0088 0.0855 0.0855
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0275 0.0275
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0085 0.0085
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0275 0.0827
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0.0074 0.0048
Brugia malayi Cathepsin L-like precursor 0.0018 0.0076 0.0076
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0751 0.4139
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0608 0.1871
Echinococcus multilocularis apoptotic protease activating factor 1 0.0031 0.0219 0.0219
Leishmania major DNA polymerase eta, putative 0.0069 0.0646 0.1991
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0275 0.0337
Schistosoma mansoni ferritin 0.0018 0.0074 0.009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0082
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0365 0.1488
Echinococcus multilocularis cysteine protease 0.0018 0.0076 0.0076
Echinococcus multilocularis survival motor neuron protein 1 0.0492 0.535 0.535
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0076 0.032
Giardia lamblia DINP protein human, muc B family 0.0059 0.0534 0.2339
Loa Loa (eye worm) hypothetical protein 0.011 0.1098 0.1098
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0011 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0082 0.0223
Brugia malayi cytochrome P450 0.0012 0.0011 0.0011
Onchocerca volvulus 0.0028 0.0193 0.0942
Trichomonas vaginalis hypothetical protein 0.007 0.0657 0.3171
Schistosoma mansoni jumonji/arid domain-containing protein 0.0129 0.1316 0.1611
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0082 0.0198
Schistosoma mansoni bromodomain containing protein 0.0071 0.0664 0.0813
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.012 0.0343
Schistosoma mansoni cytochrome P450 0.0012 0.0011 0.0013
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0074 0.0102
Trypanosoma brucei unspecified product 0.0041 0.033 0.1001
Schistosoma mansoni protein phosphatase 2C 0.0033 0.0242 0.0296
Trypanosoma brucei chrX additional, unordered contigs 0.0018 0.0082 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0534 0.1638
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0275 0.0827
Onchocerca volvulus 0.01 0.0995 0.4851
Mycobacterium leprae conserved hypothetical protein 0.0017 0.007 0.0097
Echinococcus granulosus GA binding protein alpha chain 0.0078 0.0747 0.0747
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0076 0.032
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0017 0.007 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.002 0.01 0.0437
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0346 0.105
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0068 0.018
Loa Loa (eye worm) hypothetical protein 0.0036 0.0275 0.0275
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0017 0.007 0.007
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.241 0.391
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0564 0.6148 1
Leishmania major metallo-beta-lactamase family-like protein 0.0017 0.007 0.0186
Leishmania major cathepsin L-like protease 0.0018 0.0076 0.0204
Mycobacterium ulcerans beta-lactamase 0.0036 0.0275 0.043
Mycobacterium ulcerans hypothetical protein 0.0036 0.0275 0.043
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0113 0.1136 0.5381
Schistosoma mansoni importin beta-1 0.003 0.0207 0.0253
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0054
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0033 0.0242 0.1291
Schistosoma mansoni hypothetical protein 0.0011 0.0005 0.0006
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.012 0.0342
Brugia malayi Cytochrome P450 family protein 0.0022 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0031 0.0219 0.0219
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.063 0.194
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0046 0.039 0.1188
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0036 0.0275 0.0275
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0068 0.0068
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0017 0.007 0.0333
Mycobacterium ulcerans hypothetical protein 0.0018 0.0082 0.0116
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.01 0.0437
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0068 0.0068
Schistosoma mansoni hypothetical protein 0.01 0.0995 0.1218
Schistosoma mansoni ferritin 0.0018 0.0074 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0534 0.1638
Entamoeba histolytica alkyl sulfatase, putative 0.0017 0.007 0.0292
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0005 0.0005
Echinococcus granulosus intermediate filament protein 0.0028 0.0193 0.0193
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.2051 1
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0017 0.007 0.007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0534 0.1638
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.1098 0.1098
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.011 0.1098 0.1098
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.033 0.1001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0193 0.0193
Echinococcus multilocularis Kelch repeat type 1 0.0196 0.2056 0.2056
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0242 0.0242
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0082 0.0223
Schistosoma mansoni lamin 0.0028 0.0193 0.0236
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0005 0.0006
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0017 0.007 0.0186
Brugia malayi ImpB/MucB/SamB family protein 0.0059 0.0534 0.0534
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0076 0.0076
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0534 0.0852
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.063 0.194
Schistosoma mansoni ferritin light chain 0.0018 0.0074 0.009
Echinococcus granulosus kelch ECH associated protein 1 0.0195 0.205 0.205
Trichomonas vaginalis esterase, putative 0.0036 0.0275 0.1295
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0198 0.0198
Leishmania major hypothetical protein, conserved 0.0015 0.0044 0.0105
Brugia malayi metallo-beta-lactamase superfamily protein 0.0017 0.007 0.007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.1098 0.1098
Brugia malayi Cathepsin L-like precursor 0.0018 0.0076 0.0076
Onchocerca volvulus 0.0163 0.169 0.8242
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0011 0.0011
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0068 0.0068
Onchocerca volvulus 0.0018 0.0076 0.037
Schistosoma mansoni kinase 0.0099 0.0982 0.1203
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0146 0.0424
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0068 0.0322
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0534 0.1638
Entamoeba histolytica metallo-beta-lactamase family protein 0.0017 0.007 0.0292
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.007 0.0292
Echinococcus granulosus tumor protein p63 0.0358 0.3858 0.3858
Trypanosoma brucei unspecified product 0.0059 0.0534 0.1638
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0534 0.0852
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.0019 0.0023
Echinococcus multilocularis zinc phosphodiesterase 0.0017 0.007 0.007
Schistosoma mansoni zinc finger protein 0.0028 0.019 0.0233
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0085 0.0104
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0113 0.1136 0.1136
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0005 0.0005
Brugia malayi intermediate filament protein 0.0028 0.0193 0.0193
Echinococcus granulosus kelch ECH associated protein 1 like 0.0195 0.205 0.205
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0017 0.007 0.0186
Plasmodium vivax vivapain-2 0.0018 0.0076 0.0109
Echinococcus multilocularis lysine specific demethylase 5A 0.0122 0.124 0.124
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0751 0.1206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0076 0.032
Echinococcus multilocularis kelch ECH associated protein 1 0.0195 0.205 0.205
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.2051 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.007 0.0292
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0264 0.0264
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0113 0.1136 0.1136
Schistosoma mansoni ferritin light chain 0.0018 0.0074 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0146 0.0664
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.007 0.007
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0346 0.105
Brugia malayi hypothetical protein 0.0132 0.1347 0.1347
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0068 0.018
Mycobacterium ulcerans hypothetical protein 0.0017 0.007 0.0097
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0113 0.1136 0.5516
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.012 0.012
Brugia malayi Importin beta-1 subunit 0.003 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.003
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0195 0.2051 0.6391
Schistosoma mansoni cpg binding protein 0.0095 0.0931 0.1141
Leishmania major metallo-beta-lactamase family protein-like protein 0.0017 0.007 0.0186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0076 0.032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0076 0.032
Entamoeba histolytica hypothetical protein 0.0024 0.0146 0.0664
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0076 0.0204
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0146 0.0424
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.045 0.0716
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0017 0.007 0.0186
Loa Loa (eye worm) hypothetical protein 0.0189 0.1984 0.1984
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0751 0.0751
Brugia malayi Probable ClpP-like protease 0.0078 0.0751 0.0751
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0076 0.032
Schistosoma mansoni ets-related 0.0011 0.0005 0.0006
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0076 0.0093
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0082 0.0398
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0275 0.043
Trichomonas vaginalis conserved hypothetical protein 0.002 0.01 0.0437
Echinococcus multilocularis cysteine protease 0.0018 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0036 0.0275 0.0275
Echinococcus granulosus microtubule associated protein 2 0.0745 0.8167 0.8167
Echinococcus granulosus zinc phosphodiesterase 0.0017 0.007 0.007
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0248 0.0248
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.012 0.0252
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.002 0.01 0.0437
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.063 0.194
Brugia malayi hypothetical protein 0.0147 0.1516 0.1516
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.012 0.012
Onchocerca volvulus 0.0017 0.007 0.0343
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0076 0.0076
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.0074 0.0048
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0892 0.0892
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0448 0.1371
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0017 0.007 0.0186
Brugia malayi ImpB/MucB/SamB family protein 0.011 0.1098 0.1098
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0146 0.0424
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.007 0.0292
Brugia malayi Cathepsin L-like precursor 0.0018 0.0076 0.0076
Entamoeba histolytica hypothetical protein 0.0024 0.0145 0.0657
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.2051 0.2511
Brugia malayi hypothetical protein 0.0031 0.0219 0.0219
Onchocerca volvulus 0.0036 0.0275 0.134
Mycobacterium ulcerans hypothetical protein 0.0017 0.007 0.0097
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0564 0.6148 1
Schistosoma mansoni hypothetical protein 0.0035 0.0264 0.0324
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0005 0.0005
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0178 0.0178
Trypanosoma cruzi glyoxalase II 0.0017 0.007 0.0186
Loa Loa (eye worm) hypothetical protein 0.0075 0.0712 0.0712
Loa Loa (eye worm) hypothetical protein 0.0144 0.1478 0.1478
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0275 0.043
Schistosoma mansoni phd/f-box containing protein 0.0033 0.0242 0.0296
Echinococcus granulosus lamin 0.0028 0.0193 0.0193
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0179 0.1599
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0181 0.0181
Entamoeba histolytica metallo-beta-lactamase family protein 0.0017 0.007 0.0292
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.012 0.0342
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0144 0.1478 0.1478
Schistosoma mansoni caspase-7 (C14 family) 0.0031 0.0219 0.0268
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.01 0.0437
Toxoplasma gondii hypothetical protein 0.0027 0.0179 0.0941
Loa Loa (eye worm) hypothetical protein 0.0017 0.007 0.007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.01 0.0437
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0146 0.0424
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0156 0.0813
Loa Loa (eye worm) hypothetical protein 0.0037 0.0294 0.0294
Plasmodium vivax unspecified product 0.0017 0.007 0.0028
Brugia malayi beta-lactamase family protein 0.0036 0.0275 0.0275
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.063 0.194
Entamoeba histolytica hypothetical protein 0.0147 0.1516 0.7381
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0242 0.0723
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0005 0.0005
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0076 0.037
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.2051 1
Brugia malayi Fli-1 protein 0.0237 0.2514 0.2514
Trichomonas vaginalis DNA polymerase eta, putative 0.0059 0.0534 0.2563
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0534 0.1638
Loa Loa (eye worm) hypothetical protein 0.0044 0.0364 0.0364
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.063 0.194
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0299 0.3202 1
Schistosoma mansoni hypothetical protein 0.0075 0.0712 0.0872
Echinococcus multilocularis muscleblind protein 0.091 1 1
Mycobacterium leprae POSSIBLE HYDROLASE 0.0017 0.007 0.0097
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0059 0.0534 0.2563
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0076 0.032
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.0025
Trypanosoma cruzi polo-like protein kinase, putative 0.0195 0.2051 0.6391
Brugia malayi beta-lactamase 0.0036 0.0275 0.0275
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0156 0.0455
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.012 0.1434
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0076 0.0076
Brugia malayi Ets-domain containing protein 0.0011 0.0005 0.0005
Loa Loa (eye worm) jmjC domain-containing protein 0.0129 0.1316 0.1316
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0461 0.0565
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0005 0.0005
Entamoeba histolytica type A flavoprotein, putative 0.0017 0.007 0.0292
Schistosoma mansoni myst-related protein 0.0012 0.0014 0.0018
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0751 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.004 0.0318 0.0318
Onchocerca volvulus 0.0018 0.0076 0.037
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0074 0.0102
Trichomonas vaginalis ferritin, putative 0.0018 0.0074 0.0308
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0059 0.0534 0.0534
Echinococcus granulosus cathepsin l1 0.0012 0.0011 0.0011
Onchocerca volvulus 0.0028 0.0193 0.0942
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0275 0.1295
Brugia malayi Cathepsin L-like precursor 0.0018 0.0076 0.0076
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0121 0.0121
Entamoeba histolytica hypothetical protein 0.0147 0.1516 0.7381
Trypanosoma cruzi ISWI complex protein 0.0015 0.0044 0.0105
Trypanosoma brucei beta lactamase 0.02 0.2107 0.6568
Mycobacterium tuberculosis Beta lactamase like protein 0.0017 0.007 0.0097
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0146 0.0424
Toxoplasma gondii hypothetical protein 0.0048 0.0415 0.226
Echinococcus granulosus ubiquitin specific protease 41 0.0113 0.1136 0.1136
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0003 0.0003
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0242 0.0242
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0751 0.0751
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0113 0.1136 0.3525
Schistosoma mansoni ran 0.0022 0.012 0.0147
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0113 0.1136 0.1136
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0954 0.4623
Leishmania major cathepsin L-like protease 0.0068 0.063 0.194
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0076 0.0076
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.2051 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0082 0.0223
Schistosoma mansoni hypothetical protein 0.002 0.0102 0.0125
Leishmania major cathepsin L-like protease 0.0068 0.063 0.194
Plasmodium vivax JmjC domain containing protein 0.0033 0.0242 0.2538
Schistosoma mansoni hypothetical protein 0.0011 0.0003 0.0004
Mycobacterium tuberculosis Conserved protein 0.0017 0.007 0.0097
Toxoplasma gondii cathepsin CPL 0.0018 0.0076 0.0364
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0146 0.0424
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0534 0.1638
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0113 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0132 0.1347 0.1347
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.007 0.0292
Loa Loa (eye worm) hypothetical protein 0.0078 0.0751 0.0751
Leishmania major cathepsin L-like protease 0.0018 0.0076 0.0204
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0017 0.007 0.007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0076 0.032
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0145 0.0657
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0113 0.1136 0.1136
Entamoeba histolytica deoxycytidyl transferase, putative 0.0059 0.0534 0.2563
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0608 0.0744
Schistosoma mansoni hypothetical protein 0.0017 0.007 0.0086
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0076 0.032
Entamoeba histolytica alkyl sulfatase, putative 0.0017 0.007 0.0292
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0114 0.0114
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0751 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0146 0.0424
Echinococcus granulosus zinc finger protein 0.0028 0.019 0.019
Loa Loa (eye worm) CXXC zinc finger family protein 0.0088 0.0855 0.0855
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.1452 0.4515
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0076 0.032
Echinococcus multilocularis lysine specific demethylase 6a 0.0033 0.0242 0.0242
Brugia malayi Cytochrome P450 family protein 0.0033 0.0248 0.0248
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0076 0.032
Schistosoma mansoni elf1 0.0011 0.0005 0.0006
Schistosoma mansoni apoferritin-2 0.0018 0.0074 0.009
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0275 0.1295
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0076 0.0076
Brugia malayi Ets-domain containing protein 0.0078 0.0747 0.0747
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0751 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0242 0.0242
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0264 0.0264
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0268 0.0268
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0145 0.042
Echinococcus granulosus survival motor neuron protein 1 0.0492 0.535 0.535
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.003 0.003
Echinococcus multilocularis lamin 0.0028 0.0193 0.0193
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0005 0.0005
Schistosoma mansoni cpg binding protein 0.0088 0.0855 0.1047
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.01 0.0437
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0068 0.0068
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.012 0.012
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0608 0.0608
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0145 0.0657
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0156 0.1285
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0005 0.0005
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0179 0.1622
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0005
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0068 0.0068
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.007 0.0292
Leishmania major DNA damage repair protein, putative 0.0018 0.0082 0.0223
Leishmania major hypothetical protein, conserved 0.0033 0.0242 0.0723
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.007 0.0097
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0565 0.1736
Trypanosoma brucei DNA polymerase eta, putative 0.011 0.1098 0.3406
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0181 0.0181
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0195 0.2051 0.2051
Brugia malayi Ets-domain containing protein 0.0078 0.0747 0.0747
Echinococcus granulosus importin subunit beta 1 0.003 0.0207 0.0207
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0418 0.4521 0.7349
Mycobacterium ulcerans lipase LipD 0.0036 0.0275 0.043
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0178 0.0178
Trypanosoma cruzi ISWI complex protein 0.0015 0.0044 0.0105
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0892 0.0892
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0144 0.1478 0.1478
Mycobacterium leprae conserved hypothetical protein 0.0017 0.007 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.063 0.194
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0534 0.1638
Mycobacterium tuberculosis Conserved protein 0.0036 0.0275 0.043
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0076 0.0833
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0608 0.0744
Plasmodium vivax vivapain-2 0.0018 0.0076 0.0109
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0046 0.039 0.1188
Schistosoma mansoni gabp alpha 0.0078 0.0747 0.0914
Trichomonas vaginalis conserved hypothetical protein 0.002 0.01 0.0437
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0078 0.0747 0.0747
Mycobacterium tuberculosis Possible hydrolase 0.0017 0.007 0.0097
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0098 0.0966 0.4685
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0608 0.0973
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0076 0.037
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0625 0.0625
Leishmania major cytochrome p450-like protein 0.0022 0.012 0.0342
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0113 0.1136 0.3525
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0068 0.0068
Trichomonas vaginalis A-type flavoprotein 0.0017 0.007 0.0292
Mycobacterium ulcerans beta lactamase-like protein 0.0017 0.007 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.033 0.1001
Echinococcus granulosus cathepsin l1 0.0018 0.0076 0.0076
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0122 0.124 0.124
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0275 0.043
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0068 0.0732
Trypanosoma brucei glyoxalase II 0.0017 0.007 0.0186
Brugia malayi hypothetical protein 0.0163 0.169 0.169
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0017 0.007 0.0333
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0892 0.1092
Leishmania major cathepsin L-like protease 0.0018 0.0076 0.0204
Onchocerca volvulus Huntingtin homolog 0.0132 0.1347 0.657
Echinococcus granulosus ferritin 0.0018 0.0074 0.0074
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0534 0.1638
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0275 0.0827
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0564 0.6148 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0059 0.0534 0.0852
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0017 0.007 0.0086
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0165 0.1708 0.1708
Brugia malayi cathepsin L-like precursor 0.0012 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0275 0.0275
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0365 0.1737
Toxoplasma gondii histone lysine methyltransferase SET1 0.0173 0.1798 1
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0005 0.0005
Echinococcus granulosus histone acetyltransferase KAT2B 0.0158 0.1632 0.1632
Schistosoma mansoni hypothetical protein 0.0405 0.438 0.5364
Schistosoma mansoni bromodomain containing protein 0.0013 0.0025 0.003
Brugia malayi hypothetical protein 0.0017 0.007 0.007
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0017 0.007 0.0186
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.02 0.2107 0.3416
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.1629 0.2638
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0275 0.1295
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0751 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0275 0.0275
Schistosoma mansoni tsg101-related 0.012 0.121 0.1482
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0365 0.4761
Schistosoma mansoni tsg101-related 0.012 0.121 0.1482
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0534 0.1638
Schistosoma mansoni hypothetical protein 0.0017 0.007 0.0086
Onchocerca volvulus 0.0088 0.0855 0.417
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0207 0.0614
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0076 0.0076
Schistosoma mansoni transcription factor LCR-F1 0.0147 0.1516 0.1857
Echinococcus multilocularis dna polymerase eta 0.011 0.1098 0.1098
Loa Loa (eye worm) ctsf protein 0.0018 0.0076 0.0076
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0193 0.0193
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0892 0.0892
Brugia malayi Cytochrome P450 family protein 0.0022 0.012 0.012
Giardia lamblia Kinase, PLK 0.0195 0.2051 1
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.2051 1
Schistosoma mansoni DNA polymerase eta 0.011 0.1098 0.1344
Brugia malayi Cathepsin L-like precursor 0.0012 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0011
Schistosoma mansoni tsg101-related 0.0098 0.0966 0.1183
Schistosoma mansoni ran 0.0022 0.012 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.033 0.1001
Schistosoma mansoni jumonji domain containing protein 0.0033 0.0242 0.0296
Echinococcus multilocularis expressed protein 0.0018 0.0074 0.0074
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0047 0.0047
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0275 0.1295
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0264 0.0264
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0121 0.0121
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0892 0.0892
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0011
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0625 0.0625
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0017 0.007 0.0186
Echinococcus multilocularis JmjC domain containing protein 4 0.0033 0.0242 0.0242
Onchocerca volvulus 0.0018 0.0076 0.037
Plasmodium falciparum importin beta, putative 0.003 0.0207 0.2611
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0264 0.0264
Echinococcus multilocularis ferritin 0.0018 0.0074 0.0074
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0059 0.0534 0.0534
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.003 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0163 0.169 0.169
Loa Loa (eye worm) hypothetical protein 0.091 1 1
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0017 0.007 0.0343
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0178 0.0218
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.0011 0.0005 0.0006
Mycobacterium ulcerans hypothetical protein 0.0017 0.007 0.0097
Trichomonas vaginalis ran, putative 0.0022 0.012 0.0537
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0017 0.007 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0076 0.032
Trichomonas vaginalis conserved hypothetical protein 0.002 0.01 0.0437
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0068 0.0068
Trypanosoma cruzi glyoxalase II 0.0017 0.007 0.0186
Entamoeba histolytica hypothetical protein 0.0024 0.0146 0.0664
Echinococcus multilocularis geminin 0.0509 0.5537 0.5537
Onchocerca volvulus 0.0018 0.0076 0.037
Leishmania major DNA polymerase eta, putative 0.011 0.1098 0.3406
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0435 0.2372
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1452 0.4515
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0146 0.0424
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0195 0.2051 0.2051
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0275 0.0275
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0264 0.0264
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0892 0.1092
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.438 0.438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0076 0.032
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0082 0.0223
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.131 0.131
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0418 0.4521 0.7349
Loa Loa (eye worm) hypothetical protein 0.0052 0.0461 0.0461
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0193 0.0193
Onchocerca volvulus Serine\/threonine kinase homolog 0.0195 0.2051 1
Brugia malayi beta-lactamase family protein 0.0036 0.0275 0.0275
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0275 0.0275
Entamoeba histolytica cysteine protease, putative 0.0018 0.0076 0.032
Schistosoma mansoni zinc phosphodiesterase 0.0017 0.007 0.0086
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0005 0.0005
Loa Loa (eye worm) cysteine protease 0.0018 0.0076 0.0076
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0346 0.105
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.012 0.0178
Echinococcus multilocularis importin subunit beta 1 0.003 0.0207 0.0207
Echinococcus multilocularis ubiquitin specific protease 41 0.0113 0.1136 0.1136
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0017 0.007 0.0186
Leishmania major hypothetical protein, conserved 0.0025 0.0156 0.0455
Loa Loa (eye worm) hypothetical protein 0.091 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.063 0.194
Brugia malayi Cytochrome P450 family protein 0.0012 0.0011 0.0011
Schistosoma mansoni intermediate filament proteins 0.0028 0.0193 0.0236
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0813 0.8921 0.8921
Brugia malayi Cathepsin L-like precursor 0.0018 0.0076 0.0076
Schistosoma mansoni zinc finger protein 0.0015 0.0044 0.0054
Onchocerca volvulus 0.0018 0.0076 0.037
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0033 0.0242 0.0296
Schistosoma mansoni myst-related protein 0.0012 0.0014 0.0018
Brugia malayi transcription factor E74 isoform 0.0011 0.0005 0.0005
Echinococcus multilocularis ETHE1 protein 0.0017 0.007 0.007
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0146 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0076 0.032
Leishmania major mitochondrial DNA polymerase beta 0.0299 0.3202 1
Plasmodium vivax importin-beta 2, putative 0.003 0.0207 0.2028
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0082 0.0223
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.007 0.0292
Brugia malayi polk-prov protein 0.0018 0.0082 0.0082
Echinococcus multilocularis caspase 2 0.0031 0.0219 0.0219
Mycobacterium tuberculosis Conserved protein 0.0036 0.0275 0.043
Brugia malayi jmjC domain containing protein 0.0122 0.124 0.124
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0275 0.043
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.2051 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0264 0.0264
Trichomonas vaginalis apoptosis inducing factor, putative 0.0017 0.007 0.0292
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0195 0.2051 0.2051
Entamoeba histolytica type A flavoprotein, putative 0.0017 0.007 0.0292
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0068 0.0322
Schistosoma mansoni hypothetical protein 0.0315 0.3381 0.414
Leishmania major cathepsin L-like protease 0.0018 0.0076 0.0204
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0534 0.1638
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0085 0.0104
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0207 0.1096
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0179 0.2235
Mycobacterium ulcerans hydrolase 0.0017 0.007 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.007 0.0292
Schistosoma mansoni ferritin 0.0018 0.0074 0.009
Mycobacterium ulcerans glyoxalase II, GloB 0.0017 0.007 0.0097
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.063 0.194
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0068 0.018
Trypanosoma cruzi DNA polymerase eta, putative 0.011 0.1098 0.3406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0076 0.032
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.0025
Leishmania major importin beta-1 subunit, putative 0.0024 0.0145 0.042
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0751 0.0919
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0275 0.043
Loa Loa (eye worm) hypothetical protein 0.0069 0.0644 0.0644
Echinococcus multilocularis GPCR, family 2 0.0035 0.0264 0.0264
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0954 0.4623
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0147 0.1516 0.1516
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0033 0.0242 0.0723
Schistosoma mansoni lamin 0.0028 0.0193 0.0236
Mycobacterium tuberculosis Possible hydrolase 0.0017 0.007 0.0097
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0017 0.007 0.0292
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0076 0.032
Mycobacterium ulcerans hydrolase 0.0017 0.007 0.0097
Echinococcus granulosus geminin 0.0509 0.5537 0.5537
Leishmania major GTP-binding protein, putative 0.0022 0.012 0.0343
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0146 0.0424
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.007 0.0292
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0069 0.0646 0.3555
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0121 0.0121
Onchocerca volvulus 0.0052 0.0461 0.2249
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0018 0.0082 0.0398
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.045 0.0716
Echinococcus multilocularis tumor protein p63 0.0358 0.3858 0.3858
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.0025
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0189 0.1984 0.9675
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0017 0.007 0.007
Loa Loa (eye worm) cytochrome P450 0.0012 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0033 0.0242 0.0242
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0146 0.0424
Plasmodium falciparum DNA repair protein REV1, putative 0.0018 0.0082 0.0915
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0076 0.032
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.1098 0.1098
Entamoeba histolytica Ran family GTPase 0.0022 0.012 0.0537
Schistosoma mansoni ets 0.0011 0.0005 0.0006
Schistosoma mansoni jumonji/arid domain-containing protein 0.0129 0.1316 0.1611
Brugia malayi hypothetical protein 0.0492 0.535 0.535
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0017 0.007 0.007
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0156 0.0455
Leishmania major DNA polymerase kappa, putative 0.0059 0.0534 0.1638
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0017 0.007 0.0186
Schistosoma mansoni hypothetical protein 0.0509 0.5537 0.678
Echinococcus multilocularis lamin dm0 0.0028 0.0193 0.0193
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0121 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.007 0.0292
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0534 0.1638
Trypanosoma cruzi polo-like protein kinase, putative 0.0195 0.2051 0.6391
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0113 0.1136 0.5516
Echinococcus granulosus cytochrome P450 2K1 0.0012 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0132 0.1347 0.1347
Trichomonas vaginalis conserved hypothetical protein 0.002 0.01 0.0437
Plasmodium falciparum cytosolic glyoxalase II 0.0017 0.007 0.0758
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0275 0.043
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.045 0.045
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0076 0.032
Mycobacterium leprae Probable lipase LipE 0.0036 0.0275 0.043
Leishmania major hypothetical protein, conserved 0.0036 0.0275 0.0827
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0534 0.1638
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0059 0.0534 0.0653
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0156 0.1923
Onchocerca volvulus Cell death protein 3 homolog 0.0031 0.0219 0.1066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0076 0.032
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0186 0.195 0.2387
Echinococcus multilocularis muscleblind protein 1 0.091 1 1
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0082 0.01
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0275 0.043
Trypanosoma brucei polo-like protein kinase 0.0195 0.2051 0.6391
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0017 0.007 0.007
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0068 0.018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0076 0.032
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0076 0.037
Echinococcus multilocularis phd:f box containing protein 0.0033 0.0242 0.0242
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0435 0.5371
Loa Loa (eye worm) CYP4Cod1 0.0022 0.012 0.012
Schistosoma mansoni ferritin 0.0018 0.0074 0.009
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0242 0.0723
Schistosoma mansoni hypothetical protein 0.0509 0.5537 0.678
Loa Loa (eye worm) hypothetical protein 0.0067 0.0621 0.0621
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.063 0.194
Brugia malayi Bromodomain containing protein 0.0082 0.0791 0.0791
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0275 0.1295
Brugia malayi jmjC domain containing protein 0.0129 0.1316 0.1316
Schistosoma mansoni hypothetical protein 0.0147 0.1516 0.1857
Schistosoma mansoni hypothetical protein 0.0017 0.007 0.0086
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0147 0.1516 0.1516
Loa Loa (eye worm) hypothetical protein 0.0113 0.1136 0.1136
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0146 0.0664
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.063 0.194
Giardia lamblia DNA damage repair protein 0.0018 0.0082 0.0059
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0145 0.0657
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0275 0.043
Schistosoma mansoni hypothetical protein 0.0196 0.2056 0.2518
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.01 0.0437
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.3202 1
Schistosoma mansoni hypothetical protein 0.0031 0.0219 0.0268
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0082 0.0223
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0005 0.0005
Echinococcus granulosus phd:f box containing protein 0.0033 0.0242 0.0242
Onchocerca volvulus Putative hydrolase PNKD 0.0017 0.007 0.0343
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0264 0.0264
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0082 0.0223
Mycobacterium ulcerans hypothetical protein 0.0017 0.007 0.0097
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.012 0.0343
Brugia malayi metallo-beta-lactamase superfamily protein 0.0017 0.007 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0082 0.0223
Loa Loa (eye worm) hypothetical protein 0.0033 0.0242 0.0242
Echinococcus granulosus kelch ECH associated protein 1 like 0.0195 0.205 0.205
Trichomonas vaginalis conserved hypothetical protein 0.002 0.01 0.0437
Mycobacterium tuberculosis Conserved protein 0.0017 0.007 0.0097
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.012 0.0612
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.007 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.002 0.01 0.0437
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.01 0.0437
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0005 0.0005
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.012 0.0758
Leishmania major DNA polymerase kappa, putative 0.0018 0.0082 0.0223
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0712 0.0712
Brugia malayi Cathepsin L-like precursor 0.0018 0.0076 0.0076
Echinococcus multilocularis ets variant gene 4 0.0011 0.0005 0.0005
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0017 0.007 0.0186
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.045 0.045
Brugia malayi Cathepsin L-like precursor 0.0012 0.0011 0.0011
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.012 0.0343
Trypanosoma brucei cytochrome P450, putative 0.0022 0.012 0.0342
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.063 0.194
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0264 0.0264
Brugia malayi PHD-finger family protein 0.0033 0.0248 0.0248
Brugia malayi hypothetical protein 0.0016 0.0058 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0082 0.0223
Loa Loa (eye worm) hypothetical protein 0.0036 0.0275 0.0275
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0275 0.0337
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.007 0.0292
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0076 0.032
Schistosoma mansoni hypothetical protein 0.0035 0.0264 0.0324
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0068 0.018
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0469 0.1436
Echinococcus granulosus dna polymerase kappa 0.0059 0.0534 0.0534
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.063 0.194
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.1136 0.5516
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0076 0.032
Echinococcus granulosus lamin dm0 0.0028 0.0193 0.0193
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0005 0.0005
Trypanosoma brucei ISWI complex protein 0.0015 0.0044 0.0105
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0751 1
Entamoeba histolytica hypothetical protein 0.0024 0.0146 0.0664
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0608 0.0973
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0059 0.0534 0.1638
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0068 0.0094
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0017 0.007 0.007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.01 0.0437
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0059 0.0534 0.0852
Trypanosoma cruzi glyoxalase II 0.0017 0.007 0.0186
Leishmania major cathepsin L-like protease 0.0068 0.063 0.194
Echinococcus granulosus ETHE1 protein 0.0017 0.007 0.007
Schistosoma mansoni microtubule-associated protein tau 0.0745 0.8167 1
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0146 0.0424
Brugia malayi Bromodomain containing protein 0.0041 0.0338 0.0338
Schistosoma mansoni zinc phosphodiesterase 0.0017 0.007 0.0086
Onchocerca volvulus 0.0018 0.0076 0.037
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0076 0.0076
Echinococcus granulosus snurportin 1 0.0315 0.3381 0.3381
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0751 1
Brugia malayi jmjC domain containing protein 0.0033 0.0242 0.0242
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0076 0.032
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0068 0.0084
Brugia malayi hypothetical protein 0.0025 0.0156 0.0156
Brugia malayi acetyltransferase, GNAT family protein 0.0165 0.1708 0.1708
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.01 0.0437
Echinococcus granulosus muscleblind protein 0.091 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.007 0.0292
Echinococcus granulosus JmjC domain containing protein 4 0.0033 0.0242 0.0242
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0076 0.032
Trichomonas vaginalis conserved hypothetical protein 0.002 0.01 0.0437
Schistosoma mansoni hypothetical protein 0.0012 0.0011 0.0013
Toxoplasma gondii ABC1 family protein 0.0036 0.0275 0.1477
Brugia malayi serine/threonine-protein kinase plk-2 0.0195 0.2051 0.2051
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0146 0.0424
Echinococcus granulosus dnaJ subfamily B 0.0405 0.438 0.438
Loa Loa (eye worm) hypothetical protein 0.0018 0.0076 0.0076
Mycobacterium ulcerans hydrolase 0.0017 0.007 0.0097
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0005 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.131 0.131
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0534 0.1638
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0534 0.1638
Trypanosoma brucei unspecified product 0.0041 0.033 0.1001
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0017 0.007 0.0028
Echinococcus granulosus GPCR family 2 0.0035 0.0264 0.0264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.063 0.194
Mycobacterium tuberculosis Conserved protein 0.0017 0.007 0.0097
Schistosoma mansoni hypothetical protein 0.0035 0.0264 0.0324
Echinococcus granulosus dna polymerase eta 0.011 0.1098 0.1098
Entamoeba histolytica hypothetical protein 0.0012 0.0014 0.0019
Loa Loa (eye worm) hypothetical protein 0.0492 0.535 0.535
Echinococcus multilocularis microtubule associated protein 2 0.0745 0.8167 0.8167
Entamoeba histolytica hypothetical protein 0.0147 0.1516 0.7381
Entamoeba histolytica hypothetical protein 0.0147 0.1516 0.7381
Onchocerca volvulus 0.0018 0.0076 0.037
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0193 0.0193
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0892 0.0892
Echinococcus granulosus protein C ets 2 0.0011 0.0005 0.0005
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0076 0.0204
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0165 0.1708 0.2092
Echinococcus multilocularis GA binding protein alpha chain 0.0078 0.0747 0.0747
Entamoeba histolytica hypothetical protein 0.0024 0.0146 0.0664
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.045 0.0716
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0017 0.007 0.0292
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.063 0.194
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.02 0.2107 0.3416
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0435 0.2079
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0608 0.0973
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0085 0.0085
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0082 0.0223
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0113 0.1136 0.3525
Onchocerca volvulus 0.0036 0.0275 0.134
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0113 0.1136 0.3525
Schistosoma mansoni hypothetical protein 0.0035 0.0264 0.0324
Brugia malayi MH2 domain containing protein 0.0129 0.131 0.131
Schistosoma mansoni ets-related 0.0237 0.2514 0.3079
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0179 0.0274
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0275 0.3027
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0608 0.334
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0005 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0892 0.0892
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.012 0.012
Brugia malayi RNA, U transporter 1 0.0084 0.0812 0.0812
Echinococcus granulosus lysine specific demethylase 5A 0.0129 0.1316 0.1316
Brugia malayi N-terminal motif family protein 0.0189 0.1984 0.1984
Brugia malayi ethe1-prov protein 0.0017 0.007 0.007
Mycobacterium ulcerans lipoprotein LpqF 0.02 0.2107 0.3416
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0063 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0534 0.1638
Trypanosoma cruzi DNA polymerase eta, putative 0.0069 0.0646 0.1991
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0076 0.032
Entamoeba histolytica serine/threonine protein kinase, putative 0.0195 0.2051 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0063 0.0063
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0346 0.105
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.0995 0.0995

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.07 uM Compound was tested in vitro for inhibiting electrically stimulated muscle contractions in mouse vas deferens (MVD) ChEMBL. No reference
Relative potency (functional) = 3.8 Compound was tested for relative potency with respect to the compound Enkephalinamide in MVD assay ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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