Detailed information for compound 1794865

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 370.873 | Formula: C21H23ClN2O2
  • H donors: 1 H acceptors: 1 LogP: 4.53 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)NC(=O)N1CCC2(CC1)CCc1c(O2)c(Cl)ccc1
  • InChi: 1S/C21H23ClN2O2/c1-15-5-7-17(8-6-15)23-20(25)24-13-11-21(12-14-24)10-9-16-3-2-4-18(22)19(16)26-21/h2-8H,9-14H2,1H3,(H,23,25)
  • InChiKey: RPVLQGQDRMWKED-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens transient receptor potential cation channel, subfamily M, member 8 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus transient receptor potential cation channel transient receptor potential cation channel, subfamily M, member 8 1104 aa 1115 aa 24.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0055 0.0533 0.3029
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0027 0.0004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0004
Entamoeba histolytica prolyl oligopeptidase family protein 0.0055 0.0533 0.3029
Trypanosoma cruzi subtilisin peptidase 0.0017 0.0062 0.0042
Toxoplasma gondii prefoldin subunit 6, putative 0.0063 0.0632 0.0957
Brugia malayi beta-lactamase 0.0106 0.1175 0.1726
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0035 0.0013
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0234 0.0314
Echinococcus granulosus geminin 0.0508 0.6199 0.8385
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0995 0.1346
Mycobacterium tuberculosis Probable oxidoreductase 0.0108 0.1201 0.1409
Toxoplasma gondii prolyl endopeptidase 0.052 0.6351 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0093 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0231 0.0311
Leishmania major hypothetical protein, conserved 0.0057 0.0557 0.0826
Trypanosoma cruzi kinesin, putative 0.0026 0.0169 0.0212
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0274 0.3278 0.4435
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0231 0.0231
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0093 0.0103
Loa Loa (eye worm) hypothetical protein 0.0106 0.1175 0.1562
Brugia malayi KE2 family protein 0.0063 0.0632 0.0911
Loa Loa (eye worm) calpain 0.0036 0.0306 0.0383
Brugia malayi Cathepsin L-like precursor 0.0019 0.009 0.01
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0231 0.0313
Loa Loa (eye worm) hypothetical protein 0.0031 0.0234 0.0284
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0052 0.0038
Loa Loa (eye worm) hypothetical protein 0.0106 0.1175 0.1562
Plasmodium falciparum subtilisin-like protease 3 0.0017 0.0062 0.0449
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0017 0.0062 0.0042
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0085 0.0091
Onchocerca volvulus 0.0014 0.0027 0.0005
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0738 0.1113
Trypanosoma brucei calpain-like protein, putative 0.0036 0.0306 0.0464
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.0039 0.0053
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.011
Trypanosoma brucei C-8 sterol isomerase, putative 0.0358 0.4318 0.6793
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0121 0.0273
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0231 0.0311
Trichomonas vaginalis inositol monophosphatase, putative 0.0015 0.0041 0.0018
Schistosoma mansoni hypothetical protein 0.0031 0.0234 0.0316
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0025 0.0159 0.0159
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0371 0.0371
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0085 0.006
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0093 0.0507
Toxoplasma gondii subtilisin SUB2 0.0017 0.0062 0.0056
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0121 0.0273
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0207 0.2436 0.2901
Echinococcus granulosus dna polymerase kappa 0.0019 0.0085 0.0115
Loa Loa (eye worm) hypothetical protein 0.0358 0.4318 0.5828
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0145 0.1664 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0024 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0231 0.0311
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0159 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0062 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0231 0.0311
Plasmodium falciparum prefoldin subunit 6, putative 0.0063 0.0632 1
Brugia malayi hypothetical protein 0.023 0.272 0.4042
Plasmodium falciparum subtilisin-like protease 1 0.0017 0.0062 0.0449
Onchocerca volvulus 0.0025 0.0159 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0025 0.0159 0.0394
Loa Loa (eye worm) DRP-1 protein 0.0022 0.0121 0.0132
Leishmania major hypothetical protein, conserved 0.0134 0.152 0.235
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0371 0.3451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0059 0.0073
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.053 0.0759
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0231 0.0281
Echinococcus multilocularis Furin 1 0.0017 0.0062 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0231 0.0281
Leishmania major prefoldin subunit, putative 0.0063 0.0632 0.0944
Giardia lamblia Hypothetical protein 0.0015 0.0041 0.0056
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0231 0.0313
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0017 0.0062 0.0032
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0097 0.1066 0.4279
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0231 0.0281
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.106 0.1406
Echinococcus multilocularis cathepsin b 0.0274 0.3278 0.3278
Brugia malayi beta-lactamase family protein 0.0106 0.1175 0.1726
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0055 0.0533 0.1587
Schistosoma mansoni DNA polymerase eta 0.0043 0.0394 0.0533
Onchocerca volvulus 0.0134 0.152 0.2364
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0306 0.0429
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0205 0.2412 0.3263
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0306 0.0429
Loa Loa (eye worm) hypothetical protein 0.0097 0.106 0.1406
Echinococcus multilocularis ATP binding cassette sub family B 0.0021 0.0118 0.0118
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0145 0.1664 0.2579
Trypanosoma cruzi prolyl endopeptidase 0.052 0.6351 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.003 0.0041
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0004
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0104 0.1154 0.1561
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0024 0.0033
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.0383 0.0488
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.003 0.0041
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0017 0.0062 0.0062
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0017 0.0062 0.0057
Mycobacterium ulcerans monophosphatase CysQ 0.0015 0.0041 0.0025
Entamoeba histolytica hypothetical protein 0.0111 0.1236 0.7361
Schistosoma mansoni ap endonuclease 0.0019 0.0093 0.0126
Echinococcus multilocularis dynamin 1 protein 0.0022 0.0121 0.0121
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0306 0.0429
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Toxoplasma gondii cathepsin B 0.0093 0.1007 0.155
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0121 0.0273
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0183 0.0235
Schistosoma mansoni inositol monophosphatase 0.0145 0.1664 0.2251
Brugia malayi celfurPC protein 0.0017 0.0062 0.0057
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.003 0.0041
Entamoeba histolytica cysteine protease, putative 0.0025 0.0159 0.0726
Echinococcus granulosus dna polymerase eta 0.0043 0.0394 0.0533
Trichomonas vaginalis abcb9, putative 0.0022 0.0121 0.0273
Toxoplasma gondii dynamin-related protein DRPB 0.0022 0.0121 0.0149
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Schistosoma mansoni ap endonuclease 0.0019 0.0093 0.0126
Brugia malayi hypothetical protein 0.0017 0.0066 0.0062
Schistosoma mansoni multidrug resistance protein 0.0022 0.0121 0.0163
Schistosoma mansoni hypothetical protein 0.0014 0.0024 0.0033
Entamoeba histolytica Ran family GTPase 0.0042 0.0371 0.2032
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0371 0.0531
Brugia malayi prolyl oligopeptidase family protein 0.0055 0.0533 0.0762
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0121 0.0273
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0371 0.047
Leishmania major DNA polymerase eta, putative 0.0043 0.0394 0.0568
Loa Loa (eye worm) glutathione reductase 0.0043 0.0383 0.0488
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0224 0.0312
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.003 0.0041
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0306 0.0429
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0106 0.1175 0.1589
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0231 0.0313
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.003 0.0009
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0371 0.0566
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0017 0.0062 0.0089
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0145 0.1664 0.2589
Brugia malayi RNA, U transporter 1 0.0161 0.186 0.2753
Schistosoma mansoni cathepsin F (C01 family) 0.0025 0.0159 0.0215
Schistosoma mansoni site-1 peptidase (S08 family) 0.0017 0.0062 0.0084
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0085 0.0158
Onchocerca volvulus 0.0014 0.0027 0.0005
Plasmodium vivax dynamin-like protein, putative 0.0022 0.0121 0.0754
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0004
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0104 0.1154 0.1154
Plasmodium falciparum cysteine proteinase falcipain 1 0.0017 0.0059 0.0391
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0093 0.0184
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0017 0.0062 0.0084
Brugia malayi endoprotease bli-4 precursor 0.0017 0.0062 0.0057
Onchocerca volvulus 0.0014 0.003 0.001
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0093 0.1007 0.1539
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0055 0.0533 0.072
Brugia malayi Pre-SET motif family protein 0.0209 0.2456 0.3646
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0145 0.1664 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0159 0.0394
Mycobacterium ulcerans monophosphatase CysQ 0.0015 0.0041 0.0025
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0306 0.0429
Entamoeba histolytica cysteine proteinase 2 0.0017 0.0059 0.011
Loa Loa (eye worm) hypothetical protein 0.0097 0.1059 0.1404
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0052 0.0042
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0145 0.1664 0.52
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0159 0.0394
Echinococcus granulosus survival motor neuron protein 1 0.023 0.272 0.3679
Loa Loa (eye worm) proprotein convertase 2 0.0017 0.0062 0.0052
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0121 0.0273
Echinococcus multilocularis multidrug resistance protein 1 0.0015 0.0039 0.0039
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0035 0.0017
Brugia malayi Nuclear hormone receptor E75 0.0014 0.003 0.0009
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0027 0.0004
Giardia lamblia Cathepsin B precursor 0.0093 0.1007 1
Toxoplasma gondii kringle domain-containing protein 0.0057 0.0557 0.0838
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0052 0.0042
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0995 0.1318
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0085 0.0115
Entamoeba histolytica hypothetical protein 0.0046 0.0424 0.2358
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0093 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0738 0.1145
Trypanosoma brucei Emopamil binding protein, putative 0.0134 0.152 0.2378
Loa Loa (eye worm) hypothetical protein 0.0066 0.0678 0.0887
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0035 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0062 0.0085
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0004
Loa Loa (eye worm) hypothetical protein 0.003 0.0231 0.0281
Brugia malayi Dynamin central region family protein 0.0022 0.0121 0.0146
Toxoplasma gondii subtilisin SUB9 0.0017 0.0062 0.0056
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0358 0.4318 0.644
Brugia malayi Trypsin family protein 0.01 0.1097 0.1609
Echinococcus multilocularis neuroendocrine convertase 2 0.0017 0.0062 0.0062
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0055 0.0533 0.072
Brugia malayi ecdysteroid receptor 0.003 0.0231 0.0311
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0035 0.0048
Brugia malayi hypothetical protein 0.0014 0.003 0.0009
Loa Loa (eye worm) TK/ROR protein kinase 0.0057 0.0557 0.0723
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.1097 0.1484
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0121 0.0273
Echinococcus multilocularis transmembrane protease serine 3 0.0014 0.0024 0.0024
Loa Loa (eye worm) calpain family protein 1 0.0097 0.1059 0.1404
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0371 0.2944
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0059 0.011
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0015 0.0035 0.0017
Mycobacterium tuberculosis Monophosphatase CysQ 0.0015 0.0041 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0052
Loa Loa (eye worm) endoprotease bli-4 0.0017 0.0062 0.0052
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0008
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.053 0.0718
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.0015 0.0041 0.0009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0231 0.0313
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0224 0.0224
Mycobacterium tuberculosis Probable peptidase 0.0207 0.2436 0.2901
Trypanosoma cruzi kinesin, putative 0.0026 0.0169 0.0212
Schistosoma mansoni nuclear hormone receptor 0.0014 0.003 0.0041
Echinococcus granulosus importin subunit beta 1 0.0057 0.0557 0.0754
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0015 0.0041 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.1175 0.1804
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0159 0.0394
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0052 0.007
Schistosoma mansoni zinc finger protein 0.0014 0.003 0.0041
Echinococcus multilocularis cysteine protease 0.0025 0.0159 0.0159
Echinococcus granulosus calpain A 0.0105 0.1157 0.1565
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0085 0.0115
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0231 0.0281
Schistosoma mansoni hypothetical protein 0.0508 0.6199 0.8385
Schistosoma mansoni hypothetical protein 0.0066 0.0678 0.0917
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0738 0.1145
Schistosoma mansoni myo inositol monophosphatase 0.0015 0.0041 0.0055
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0134 0.152 0.235
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0234 0.0314
Mycobacterium ulcerans monophosphatase 0.0015 0.0041 0.0025
Toxoplasma gondii subtilisin SUB12 0.0031 0.0238 0.0334
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0062 0.0085
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0035 0.0036
Brugia malayi mbt repeat family protein 0.0048 0.0448 0.0635
Leishmania major cathepsin L-like protease 0.0025 0.0159 0.0195
Entamoeba histolytica protein kinase, putative 0.0026 0.0169 0.0792
Brugia malayi Inositol monophosphatase family protein 0.0015 0.0041 0.0025
Mycobacterium ulcerans hypothetical protein 0.0106 0.1175 0.1739
Leishmania major kinesin, putative 0.0026 0.0169 0.0212
Onchocerca volvulus 0.0025 0.0159 0.0213
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0093 0.0355
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0145 0.1664 0.2579
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0097 0.1066 0.1245
Brugia malayi calpain 7 0.0036 0.0306 0.0423
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Giardia lamblia Cathepsin B precursor 0.0093 0.1007 1
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0055 0.0533 0.08
Plasmodium falciparum multidrug resistance protein 1 0.0022 0.0121 0.1431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0159 0.0394
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0093 0.0968
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.1175 0.1804
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0231 0.0313
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0121 0.0163
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0738 0.1113
Brugia malayi prolyl oligopeptidase family protein 0.0055 0.0533 0.0762
Onchocerca volvulus 0.0025 0.0159 0.0213
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0055 0.0533 0.1587
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0207 0.2436 0.3644
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.003 0.0008
Brugia malayi Muscleblind-like protein 0.0145 0.1663 0.2458
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0004
Brugia malayi Dynamin 0.0023 0.0142 0.0177
Loa Loa (eye worm) hypothetical protein 0.0021 0.0118 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0231 0.0281
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0008
Giardia lamblia Cathepsin B precursor 0.0093 0.1007 1
Mycobacterium tuberculosis Probable esterase LipL 0.0106 0.1175 0.1377
Trypanosoma brucei prolyl oligopeptidase, putative 0.0207 0.2436 0.3823
Loa Loa (eye worm) inositol-1 0.0145 0.1664 0.2226
Loa Loa (eye worm) glutaminase 0.0266 0.3167 0.4266
Brugia malayi Inositol-1 0.0145 0.1664 0.2459
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0024 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0306 0.0464
Mycobacterium tuberculosis Probable oxidoreductase 0.0544 0.6642 0.7985
Trypanosoma brucei calpain-like protein, putative 0.0036 0.0306 0.0464
Loa Loa (eye worm) hypothetical protein 0.003 0.0231 0.0281
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0038
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0557 0.0557
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0274 0.3278 0.4435
Echinococcus granulosus Furin 1 0.0017 0.0062 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0093 0.1007 0.3104
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0207 0.2436 0.3801
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0231 0.0313
Loa Loa (eye worm) hypothetical protein 0.0106 0.1175 0.1562
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Plasmodium vivax subtilisin-like protease 1 0.0017 0.0062 0.0235
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0085 0.0115
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0015 0.0041 0.0055
Leishmania major GTP-binding protein, putative 0.0042 0.0371 0.0531
Trypanosoma cruzi Emopamil binding protein, putative 0.0134 0.152 0.235
Brugia malayi prolyl oligopeptidase family protein 0.0055 0.0533 0.0762
Chlamydia trachomatis 3'(2'),5'-bisphosphate nucleotidase CysQ 0.0015 0.0041 0.0643
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.009 0.0176
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0093 0.0091
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0121 0.0273
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0036 0.0306 0.0429
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0017 0.0062 0.0042
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0017 0.0062 0.0079
Echinococcus granulosus snurportin 1 0.0604 0.7393 1
Onchocerca volvulus 0.0019 0.009 0.0105
Brugia malayi calpain family protein 1 0.0097 0.1059 0.1551
Brugia malayi hypothetical protein 0.0014 0.003 0.0009
Plasmodium vivax hypothetical protein, conserved 0.0106 0.1175 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0024 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0159 0.0394
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0738 0.1145
Brugia malayi ABC transporter family protein 0.0022 0.0121 0.0145
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0015 0.0041 0.0018
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0233 0.0325
Echinococcus multilocularis cysteine protease 0.0025 0.0159 0.0159
Echinococcus granulosus cysteine protease 0.0017 0.0059 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0085 0.0115
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0106 0.1175 0.1739
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0038
Echinococcus granulosus cathepsin L cysteine proteinase 0.0025 0.0159 0.0215
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0121 0.0273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0159 0.0394
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0231 0.0313
Schistosoma mansoni dynamin 0.0022 0.0121 0.0164
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0224 0.0304
Brugia malayi multidrug resistance protein 3 0.0022 0.0121 0.0145
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.1236 0.1236
Loa Loa (eye worm) hypothetical protein 0.0106 0.1175 0.1562
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0231 0.0311
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0085 0.0079
Onchocerca volvulus 0.01 0.1097 0.1696
Leishmania major DNA polymerase kappa, putative 0.0019 0.0085 0.0079
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0231 0.0313
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0231 0.0231
Trichomonas vaginalis glutaminase, putative 0.0266 0.3167 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0145 0.1664 0.52
Loa Loa (eye worm) hypothetical protein 0.0055 0.0533 0.069
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0448 0.0606
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0233 0.0312
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0085 0.0115
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0059 0.0079
Brugia malayi Pre-SET motif family protein 0.003 0.0224 0.03
Schistosoma mansoni calpain-7 (C02 family) 0.0036 0.0306 0.0414
Plasmodium falciparum glutathione reductase 0.0043 0.0383 0.5834
Echinococcus multilocularis muscleblind protein 0.0145 0.1663 0.1663
Loa Loa (eye worm) calpain 5 0.0026 0.0169 0.0197
Onchocerca volvulus 0.0014 0.0027 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0085 0.0115
Brugia malayi Cathepsin L-like precursor 0.0025 0.0159 0.0202
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0055 0.0533 0.0804
Schistosoma mansoni cathepsin F (C01 family) 0.0025 0.0159 0.0215
Plasmodium vivax vivapain-1 0.0017 0.0059 0.0205
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0121 0.0163
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0231 0.0313
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0231 0.0311
Toxoplasma gondii hypothetical protein 0.0055 0.0533 0.08
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0017 0.0062 0.0084
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0121 0.0163
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0448 0.0448
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0059 0.0052
Onchocerca volvulus 0.0106 0.1175 0.1819
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0738 0.1145
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0231 0.0311
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0231 0.0231
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0085 0.0115
Echinococcus granulosus cathepsin l1 0.0025 0.0159 0.0215
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.106 0.1554
Onchocerca volvulus 0.0025 0.0159 0.0213
Brugia malayi Inositol monophosphatase family protein 0.0015 0.0041 0.0025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0159 0.0394
Trypanosoma brucei kinesin, putative 0.0026 0.0169 0.0248
Echinococcus granulosus prolyl endopeptidase 0.052 0.6351 0.8591
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0211 0.0285
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0017 0.0062 0.0084
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.011
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.009 0.0306
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.003 0.001
Loa Loa (eye worm) hypothetical protein 0.0106 0.1175 0.1562
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0159 0.0394
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0231 0.0231
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0121 0.0273
Echinococcus multilocularis calpain 7 (C02 family) 0.0036 0.0306 0.0306
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.003 0.0231 0.0281
Echinococcus granulosus FTZ F1 alpha 0.003 0.0231 0.0313
Brugia malayi Nuclear hormone receptor E75 0.0014 0.003 0.0009
Brugia malayi hypothetical protein 0.0016 0.0052 0.0042
Echinococcus granulosus GPCR family 2 0.0031 0.0234 0.0316
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.0383 0.0421
Toxoplasma gondii dynamin gtpase 0.0014 0.0029 0.0003
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0022 0.0121 0.0148
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0055 0.0533 0.072
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.057 0.0846
Entamoeba histolytica prefoldin subunit 6, putative 0.0063 0.0632 0.3641
Plasmodium falciparum dynamin-like protein 0.0022 0.0121 0.1441
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0085 0.0115
Trichomonas vaginalis dynamin, putative 0.0022 0.0121 0.0274
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0059 0.0079
Mycobacterium leprae Possible secreted protease 0.0017 0.0062 0.0089
Toxoplasma gondii subtilisin SUB6 0.0017 0.0062 0.0056
Mycobacterium tuberculosis Conserved protein 0.0106 0.1175 0.1377
Echinococcus multilocularis GPCR, family 2 0.0031 0.0234 0.0234
Loa Loa (eye worm) multidrug resistance protein 3 0.0022 0.0121 0.0131
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0024 0.0033
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0106 0.1175 0.1726
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0017 0.0062 0.0032
Brugia malayi nuclear hormone receptor 0.003 0.0231 0.0311
Trichomonas vaginalis dynamin, putative 0.0022 0.0121 0.0274
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0097 0.1059 0.1432
Onchocerca volvulus 0.006 0.0603 0.0915
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0017 0.0062 0.0057
Schistosoma mansoni calpain C (C02 family) 0.0036 0.0306 0.0414
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0224 0.0304
Trypanosoma brucei calpain-like protein, putative 0.0036 0.0306 0.0464
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0383 0.0551
Toxoplasma gondii subtilisin SUB5 0.0017 0.0062 0.0056
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0038
Mycobacterium ulcerans lipase LipD 0.0106 0.1175 0.1739
Trichomonas vaginalis esterase, putative 0.0106 0.1175 0.3638
Loa Loa (eye worm) hypothetical protein 0.0019 0.009 0.009
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.053 0.0718
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0424 0.124
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0017 0.0062 0.0089
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0306 0.0429
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.003 0.003
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.009 0.0122
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0093 0.0104
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0448 0.0606
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.1422 0.1897
Echinococcus multilocularis cathepsin b 0.0274 0.3278 0.3278
Brugia malayi Cathepsin L-like precursor 0.0025 0.0159 0.0202
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0678 0.098
Mycobacterium tuberculosis Probable lipase LipE 0.0106 0.1175 0.1377
Leishmania major DNA polymerase eta, putative 0.0031 0.0233 0.0312
Echinococcus granulosus muscleblind protein 0.0145 0.1663 0.225
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.067 0.1005
Schistosoma mansoni ran 0.0042 0.0371 0.0501
Echinococcus granulosus prefoldin subunit 6 0.0063 0.0632 0.0855
Brugia malayi beta-lactamase family protein 0.0106 0.1175 0.1726
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0121 0.0273
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.053 0.0718
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0159 0.0726
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0677 0.831 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0995 0.0995
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.011
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.003 0.001
Entamoeba histolytica P-glycoprotein-5 0.0022 0.0121 0.0492
Plasmodium vivax subtilisin-like protease 2, putative 0.0017 0.0062 0.0235
Echinococcus granulosus furin 0.0017 0.0062 0.0084
Schistosoma mansoni dynamin 0.0023 0.0142 0.0192
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0027 0.0004
Leishmania major C-8 sterol isomerase-like protein 0.0358 0.4318 0.6782
Onchocerca volvulus 0.0086 0.0924 0.1422
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Giardia lamblia DINP protein human, muc B family 0.0019 0.0085 0.051
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Loa Loa (eye worm) hypothetical protein 0.0023 0.0142 0.016
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0027 0.0004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0106 0.1175 0.1589
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0231 0.0313
Entamoeba histolytica dynamin-1-like protein, putative 0.0022 0.0121 0.0496
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0159 0.0394
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0121 0.0273
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0015 0.0041 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0632 0.1905
Brugia malayi neuroendocrine convertase 1 precursor 0.0017 0.0062 0.0057
Echinococcus multilocularis inositol monophosphatase 1 0.0145 0.1664 0.1664
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0121 0.0163
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0205 0.2412 0.2412
Brugia malayi glutaminase DH11.1 0.0266 0.3167 0.4714
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0024 0.0033
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0207 0.2436 0.3801
Plasmodium falciparum cysteine proteinase falcipain 3 0.0025 0.0159 0.2067
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0085 0.0115
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0371 0.0544
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.011
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0533 0.0787
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0207 0.2436 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0448 0.0575
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0557 0.0839
Echinococcus multilocularis 0.0017 0.0062 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0085 0.0115
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0183 0.2483
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0448 0.067
Plasmodium falciparum importin beta, putative 0.0057 0.0557 0.875
Trypanosoma brucei hypothetical protein, conserved 0.0106 0.1175 0.1834
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0108 0.1201 0.1409
Giardia lamblia Dynamin 0.0022 0.0121 0.0884
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0306 0.0429
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0995 0.1346
Trichomonas vaginalis abcb9, putative 0.0022 0.0121 0.0273
Loa Loa (eye worm) hypothetical protein 0.006 0.0603 0.0786
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0052 0.007
Trypanosoma brucei inositol polyphosphate 1-phosphatase, putative 0.0015 0.0041 0.0045
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0017 0.0062 0.0032
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0134 0.152 0.235
Brugia malayi prolyl oligopeptidase family protein 0.052 0.6351 0.9488
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0274 0.3278 0.5135
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0231 0.0311
Mycobacterium ulcerans esterase/lipase LipP 0.0106 0.1175 0.1739
Loa Loa (eye worm) hypothetical protein 0.0145 0.1663 0.2224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0738 0.1145
Echinococcus multilocularis cathepsin L 0.0017 0.0059 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0738 0.1145
Leishmania major cathepsin L-like protease 0.0071 0.0738 0.1113
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.053 0.053
Echinococcus multilocularis membrane bound transcription factor site 1 0.0017 0.0062 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0025 0.0159 0.0394
Loa Loa (eye worm) hypothetical protein 0.0106 0.1175 0.1562
Loa Loa (eye worm) subtilase 0.0548 0.6692 0.905
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0036 0.0306 0.0464
Echinococcus granulosus dynamin 1 0.0023 0.0142 0.0192
Loa Loa (eye worm) hypothetical protein 0.0019 0.009 0.009
Leishmania major GTP-binding protein, putative 0.0022 0.0121 0.0136
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0055 0.0533 0.0533
Plasmodium vivax unspecified product 0.0017 0.0059 0.0205
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0145 0.1664 0.2606
Onchocerca volvulus 0.0057 0.0557 0.0842
Schistosoma mansoni survival motor neuron protein 0.0047 0.0436 0.059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0159 0.0394
Entamoeba histolytica calpain large subunit domain III containing protein 0.0026 0.0169 0.0792
Echinococcus multilocularis calpain 0.0036 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0025 0.0159 0.0183
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0183 0.2483
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0306 0.0429
Onchocerca volvulus 0.0025 0.0159 0.0213
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0358 0.4318 0.6782
Trichomonas vaginalis mgm1, putative 0.0022 0.0121 0.0274
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0014 0.0024 0.0033
Echinococcus multilocularis enteropeptidase 0.0014 0.0024 0.0024
Onchocerca volvulus 0.0014 0.0027 0.0005
Trypanosoma cruzi oligopeptidase b 0.0207 0.2436 0.3801
Schistosoma mansoni thyroid hormone receptor 0.003 0.0231 0.0313
Loa Loa (eye worm) hypothetical protein 0.003 0.0231 0.0281
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0055 0.0533 0.0787
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0004
Leishmania major trypanothione reductase 0.0043 0.0383 0.0551
Echinococcus granulosus cathepsin L 0.0017 0.0059 0.0079
Echinococcus multilocularis calpain A 0.0105 0.1157 0.1157
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0394 0.0555
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0017 0.0062 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0738 0.1145
Echinococcus granulosus inositol monophosphatase 0.0015 0.0041 0.0055
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0234 0.0234
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0231 0.0327
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.003 0.0041
Echinococcus multilocularis beta LACTamase domain containing family member 0.0106 0.1175 0.1175
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Schistosoma mansoni hypothetical protein 0.0063 0.0632 0.0855
Brugia malayi steroid hormone receptor 0.003 0.0231 0.0311
Echinococcus granulosus membrane bound transcription factor site 1 0.0017 0.0062 0.0084
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0085 0.0092
Leishmania major cathepsin L-like protease 0.0071 0.0738 0.1113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0231 0.0281
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0022 0.0121 0.0131
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0274 0.3278 0.4435
Leishmania major hypothetical protein, conserved 0.0027 0.0183 0.0235
Loa Loa (eye worm) beta-lactamase 0.0106 0.1175 0.1562
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.003 0.003
Echinococcus multilocularis tissue type plasminogen activator 0.0057 0.0557 0.0557
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.1236 0.1672
Plasmodium vivax SET domain protein, putative 0.003 0.0224 0.1659
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0059 0.0075
Schistosoma mansoni hypothetical protein 0.0031 0.0234 0.0316
Echinococcus multilocularis prolyl endopeptidase 0.052 0.6351 0.6351
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.1236 0.1672
Loa Loa (eye worm) hypothetical protein 0.01 0.1097 0.1457
Leishmania major p-glycoprotein 0.0022 0.0121 0.0135
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0274 0.3278 0.4435
Brugia malayi Kringle domain containing protein 0.0057 0.0557 0.0799
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0008
Onchocerca volvulus 0.003 0.0224 0.0317
Echinococcus multilocularis snurportin 1 0.0604 0.7393 0.7393
Leishmania major cathepsin L-like protease 0.0025 0.0159 0.0195
Entamoeba histolytica dynamin-like protein 0.0022 0.0121 0.0496
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0121 0.0273
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0059 0.0037
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0306 0.0429
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0093 0.1007 0.1363
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0121 0.0163
Onchocerca volvulus 0.0014 0.0027 0.0005
Plasmodium vivax subtilisin-like serine protease, putative 0.0017 0.0062 0.0235
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0008
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0055 0.0533 0.0821
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0085 0.0115
Mycobacterium tuberculosis Probable lipase LipD 0.0106 0.1175 0.1377
Echinococcus granulosus calpain 7 C02 family 0.0036 0.0306 0.0414
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0024 0.0033
Onchocerca volvulus 0.0014 0.0027 0.0005
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.011
Schistosoma mansoni inositol monophosphatase 0.0145 0.1664 0.2251
Brugia malayi Cathepsin L-like precursor 0.0019 0.009 0.01
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Echinococcus multilocularis cathepsin L cysteine protease 0.0025 0.0159 0.0159
Echinococcus granulosus Dipeptidyl peptidase 9 0.0055 0.0533 0.072
Brugia malayi Dynamin 0.0023 0.0142 0.0177
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0059 0.0037
Entamoeba histolytica prolyl oligopeptidase family protein 0.0055 0.0533 0.3029
Schistosoma mansoni multidrug resistance protein 0.0022 0.0121 0.0163
Echinococcus granulosus inositol monophosphatase 1 0.0145 0.1664 0.2251
Loa Loa (eye worm) hypothetical protein 0.01 0.1097 0.1457
Trypanosoma brucei oligopeptidase b 0.0207 0.2436 0.3823
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0017 0.0062 0.0084
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0121 0.0273
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0371 0.052
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0008
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0085 0.0085
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0035 0.0036
Mycobacterium tuberculosis Conserved protein 0.0106 0.1175 0.1377
Trypanosoma brucei cysteine peptidase C (CPC) 0.0093 0.1007 0.157
Toxoplasma gondii subtilisin SUB7 0.0017 0.0062 0.0056
Schistosoma mansoni site-1 peptidase (S08 family) 0.0017 0.0062 0.0084
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0022 0.0121 0.0103
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0004
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.039 0.039
Schistosoma mansoni hypothetical protein 0.0294 0.3529 0.4774
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0108 0.1201 0.1409
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.011
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0093 0.1007 0.1539
Toxoplasma gondii subtilisin SUB11 0.0017 0.0062 0.0056
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.2456 0.33
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0055 0.0533 0.0787
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0004
Entamoeba histolytica P-glycoprotein-2 0.0022 0.0121 0.0492
Echinococcus granulosus calpain A 0.0036 0.0306 0.0414
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0035 0.0036
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0015 0.0035 0.0017
Plasmodium falciparum thioredoxin reductase 0.0043 0.0383 0.5834
Schistosoma mansoni coup transcription factor 0.003 0.0231 0.0313
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0015 0.0035 0.0017
Brugia malayi Thioredoxin reductase 0.0043 0.0383 0.0539
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0448 0.0606
Brugia malayi calpain family protein 1 0.0097 0.1059 0.1551
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0995 0.0995
Entamoeba histolytica hypothetical protein 0.0111 0.1236 0.7361
Toxoplasma gondii hypothetical protein 0.0015 0.0041 0.0022
Entamoeba histolytica P-glycoprotein-1 0.0022 0.0121 0.0492
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.003 0.0009
Echinococcus multilocularis cathepsin L cysteine protease 0.0025 0.0159 0.0159
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0085 0.0115
Onchocerca volvulus 0.0022 0.0121 0.0153
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0424 0.0615
Schistosoma mansoni dynamin 0.0023 0.0142 0.0192
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0604 0.7393 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0024 0.0033
Brugia malayi proprotein convertase 2 0.0017 0.0062 0.0057
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.039 0.0528
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.003 0.0231 0.0281
Entamoeba histolytica prolyl oligopeptidase family protein 0.0055 0.0533 0.3029
Brugia malayi nuclear receptor RXR 0.0014 0.003 0.0009
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.011
Loa Loa (eye worm) ctsf protein 0.0025 0.0159 0.0183
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0059 0.011
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0057 0.0557 0.4575
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0231 0.0311
Trypanosoma brucei subtilisin peptidase 0.0017 0.0062 0.0079
Brugia malayi prolyl oligopeptidase family protein 0.0055 0.0533 0.0762
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0183 0.027
Plasmodium falciparum dynamin-like protein 0.0022 0.0121 0.1441
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0055 0.0533 0.08
Onchocerca volvulus Inositol monophosphatase 3 homolog 0.0015 0.0041 0.0026
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0085 0.0115
Plasmodium vivax multidrug resistance protein 1, putative 0.0022 0.0121 0.0749
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0052 0.007
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0093 0.0094
Schistosoma mansoni hypothetical protein 0.0111 0.1236 0.1672
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.0121 0.0121
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0448 0.0606
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0027 0.0183 0.0216
Plasmodium vivax calpain, putative 0.0036 0.0306 0.2379
Echinococcus granulosus calpain 0.0036 0.0306 0.0414
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0231 0.0313
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0231 0.0311
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0097 0.1066 0.1245
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0021 0.0118 0.0159
Echinococcus multilocularis dynamin 1 0.0023 0.0142 0.0142
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.003 0.003
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0557 0.086
Schistosoma mansoni hypothetical protein 0.0015 0.0041 0.0055
Trichomonas vaginalis penicillin-binding protein, putative 0.0106 0.1175 0.3638
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Echinococcus granulosus Mastin 0.0014 0.0024 0.0033
Brugia malayi ecdysone receptor 0.0014 0.003 0.0009
Echinococcus multilocularis hypothetical protein 0.0036 0.0306 0.0306
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.1175 0.3638
Giardia lamblia Hypothetical protein 0.0063 0.0632 0.6137
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0436 0.0618
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0424 0.124
Onchocerca volvulus 0.0237 0.2816 0.4412
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0004
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0035 0.0048
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0159 0.0202
Echinococcus multilocularis geminin 0.0508 0.6199 0.6199
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0008
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.0039 0.0053
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0085 0.0079
Mycobacterium ulcerans beta-lactamase 0.0106 0.1175 0.1739
Schistosoma mansoni importin beta-1 0.0057 0.0557 0.0754
Onchocerca volvulus 0.0014 0.003 0.001
Plasmodium falciparum cysteine repeat modular protein 1 0.0057 0.0557 0.8741
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0023
Leishmania major cysteine peptidase A (CPA) 0.0025 0.0159 0.0195
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0106 0.1175 0.1377
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0121 0.0121
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.003 0.003
Entamoeba histolytica cysteine proteinase 1, putative 0.0017 0.0059 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.009 0.009
Schistosoma mansoni hypothetical protein 0.0031 0.0234 0.0316
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0093 0.0322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0159 0.0394
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0025 0.0159 0.0159
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0159 0.0726
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0231 0.0311
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0024 0.0033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0059 0.011
Echinococcus multilocularis dna polymerase eta 0.0043 0.0394 0.0394
Schistosoma mansoni calpain-7 (C02 family) 0.0036 0.0306 0.0414
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0231 0.0231
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.106 0.1554
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0004
Echinococcus granulosus beta LACTamase domain containing family member 0.0106 0.1175 0.1589
Brugia malayi nuclear receptor NHR-88 0.003 0.0231 0.0311
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0121 0.0121
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0052 0.0052
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0231 0.0327
Echinococcus granulosus cathepsin b 0.0274 0.3278 0.4435
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0121 0.0273
Loa Loa (eye worm) hypothetical protein 0.0183 0.2134 0.2864
Leishmania major inositol polyphosphate 1-phosphatase, putative 0.0015 0.0041 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Entamoeba histolytica P-glycoprotein-2, putative 0.0022 0.0121 0.0492
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0306 0.0429
Entamoeba histolytica hypothetical protein 0.0111 0.1236 0.7361
Plasmodium falciparum peptidase, putative 0.0055 0.0533 0.8335
Leishmania major cathepsin L-like protease 0.0025 0.0159 0.0195
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0145 0.1664 0.2579
Schistosoma mansoni hypothetical protein 0.0047 0.0436 0.059
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0738 0.1113
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0014 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.003 0.0231 0.0281
Echinococcus granulosus neuroendocrine convertase 2 0.0017 0.0062 0.0084
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0231 0.0313
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.003 0.0009
Brugia malayi hypothetical protein 0.0111 0.1236 0.1817
Loa Loa (eye worm) hypothetical protein 0.0274 0.3278 0.4416
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.003 0.003
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0207 0.2436 0.3801
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0231 0.0311
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0059 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.009 0.0176
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0224 0.0304
Brugia malayi Cathepsin L-like precursor 0.0025 0.0159 0.0202
Entamoeba histolytica P-glycoprotein 5, putative 0.0022 0.0121 0.0492
Loa Loa (eye worm) hypothetical protein 0.023 0.272 0.3658
Brugia malayi hypothetical protein 0.0016 0.0052 0.0042
Mycobacterium tuberculosis Probable hydrolase 0.0106 0.1175 0.1377
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0121 0.0273
Onchocerca volvulus 0.0047 0.0436 0.0651
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0085 0.0158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0159 0.0394
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0231 0.0311
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0023
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0394 0.0568
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0231 0.0231
Loa Loa (eye worm) calpain family protein 1 0.0071 0.074 0.0972
Mycobacterium ulcerans short chain dehydrogenase 0.0544 0.6642 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0231 0.0313
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0059 0.0052
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0017 0.0062 0.0057
Toxoplasma gondii subtilisin SUB10 0.0017 0.0062 0.0056
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1663 0.1663
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0008
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0055 0.0533 0.072
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0022 0.0121 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0272
Loa Loa (eye worm) hypothetical protein 0.003 0.0231 0.0281
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.1175 0.3638
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0207 0.2436 0.3823
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0159 0.0394
Echinococcus granulosus transmembrane protease serine 3 0.0014 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0022 0.0121 0.0131
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0231 0.0311
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0014 0.0024 0.0024
Brugia malayi Cathepsin L-like precursor 0.0025 0.0159 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0533 0.1587
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.272 0.272
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0145 0.1664 0.2478
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0995 0.1346
Trypanosoma brucei dynamin-1-like protein 0.0022 0.0121 0.0172
Onchocerca volvulus 0.003 0.0231 0.0327
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0121 0.0273
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.2252 0.3047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0738 0.1145
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0085 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0062 0.0085
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.052 0.6351 0.8591
Mycobacterium leprae Probable lipase LipE 0.0106 0.1175 0.4735
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0121 0.0273
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.2252 0.2252
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0017 0.0062 0.0032
Toxoplasma gondii subtilisin SUB8 0.0017 0.0062 0.0056
Trichomonas vaginalis dynamin, putative 0.0022 0.0121 0.0274
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0024 0.0033
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0121 0.0273
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0234 0.0316
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0371 0.0531
Schistosoma mansoni multidrug resistance protein 0.0022 0.0121 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0085 0.0115
Onchocerca volvulus 0.0014 0.0027 0.0005
Echinococcus multilocularis inositol monophosphatase 0.0015 0.0041 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0738 0.1145
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0995 0.1456
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.052 0.6351 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0145 0.1664 0.52
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0085 0.0272
Mycobacterium ulcerans glutaminase 0.0266 0.3167 0.4749
Echinococcus granulosus glycoprotein Antigen 5 0.0014 0.0024 0.0033
Trypanosoma cruzi Emopamil binding protein, putative 0.0134 0.152 0.235
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0027 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0224 0.0304
Echinococcus multilocularis prefoldin subunit 6 0.0063 0.0632 0.0632
Echinococcus granulosus calpain 5 0.0036 0.0306 0.0414
Plasmodium vivax glutathione reductase, putative 0.0043 0.0383 0.3054
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0106 0.1175 0.1377
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0085 0.0115
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.052 0.6351 0.8591
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0017 0.0062 0.0042
Brugia malayi cathepsin L-like precursor 0.0019 0.009 0.01
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0231 0.0281
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0004
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0038
Trypanosoma brucei dynamin-1-like protein 0.0022 0.0121 0.0172
Trypanosoma brucei unspecified product 0.0019 0.0085 0.0115
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.003 0.0009
Schistosoma mansoni nuclear hormone receptor 0.0014 0.003 0.0041
Leishmania major cathepsin L-like protease 0.0025 0.0159 0.0195
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.003 0.0008
Onchocerca volvulus 0.0014 0.0027 0.0005
Loa Loa (eye worm) hypothetical protein 0.0145 0.1663 0.2224
Schistosoma mansoni glutaminase 0.0266 0.3167 0.4284
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0466 0.5669 0.6809
Echinococcus multilocularis calpain 5 0.0036 0.0306 0.0306
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0024 0.0033
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0231 0.0327
Loa Loa (eye worm) cysteine protease 0.0025 0.0159 0.0183
Echinococcus granulosus tissue type plasminogen activator 0.0057 0.0557 0.0753
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.003 0.003
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0448 0.0448
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0085 0.0079
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0085 0.006
Onchocerca volvulus 0.0048 0.0448 0.067
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.011
Schistosoma mansoni hypothetical protein 0.0031 0.0234 0.0316
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0055 0.0533 0.0787
Brugia malayi MH2 domain containing protein 0.0126 0.1422 0.2096
Trichomonas vaginalis dynamin, putative 0.0022 0.0121 0.0274
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0231 0.0313
Brugia malayi Importin beta-1 subunit 0.0057 0.0557 0.08
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0055 0.0533 0.072
Schistosoma mansoni thyroid hormone receptor 0.003 0.0231 0.0313
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.003 0.0041
Schistosoma mansoni hypothetical protein 0.0015 0.0041 0.0055
Onchocerca volvulus 0.0014 0.0027 0.0005
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0234 0.0284
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0024 0.0033
Onchocerca volvulus Cathepsin L homolog 0.0025 0.0159 0.0213
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0059 0.0073
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0371 0.0501
Brugia malayi Cathepsin L-like precursor 0.0025 0.0159 0.0202
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0024 0.0024
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0448 0.0575
Loa Loa (eye worm) hypothetical protein 0.0057 0.0557 0.0723
Loa Loa (eye worm) hypothetical protein 0.0071 0.074 0.0972
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0093 0.0091
Plasmodium vivax vivapain-2 0.0025 0.0159 0.1082
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0424 0.124
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0159 0.0394
Onchocerca volvulus 0.0014 0.0027 0.0005
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0121 0.0273
Brugia malayi nuclear receptor NHR-67 0.0014 0.003 0.0009
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.003 0.0041
Brugia malayi hypothetical protein 0.0027 0.0183 0.0239
Brugia malayi nuclear receptor NHR-88 0.0014 0.003 0.0009
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0121 0.0121
Trichomonas vaginalis taga, putative 0.0022 0.0121 0.0273
Entamoeba histolytica P-glyco protein 6, putative 0.0022 0.0121 0.0492
Toxoplasma gondii cathepsin CPL 0.0025 0.0159 0.0208
Loa Loa (eye worm) hypothetical protein 0.0063 0.0632 0.0825
Loa Loa (eye worm) hypothetical protein 0.0055 0.0533 0.069
Mycobacterium tuberculosis Probable reductase 0.0097 0.1066 0.1245
Echinococcus granulosus cathepsin l1 0.0019 0.009 0.0122
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0106 0.1175 0.1562
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Echinococcus granulosus acylamino acid releasing enzyme 0.0055 0.0533 0.072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0159 0.0394
Trypanosoma cruzi dynamin-1-like protein 0.0022 0.0121 0.0136
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.003 0.0008
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0025 0.0159 0.2067
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.053 0.053
Echinococcus multilocularis acylamino acid releasing enzyme 0.0055 0.0533 0.0533
Schistosoma mansoni calpain (C02 family) 0.0036 0.0306 0.0414
Echinococcus granulosus enteropeptidase 0.0014 0.0024 0.0033
Onchocerca volvulus 0.0025 0.0159 0.0213
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.003 0.0041
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0448 0.0606
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0306 0.0429
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.011
Trichomonas vaginalis dynamin, putative 0.0022 0.0121 0.0274
Brugia malayi tailless protein 0.0014 0.003 0.0009
Brugia malayi cathepsin B-like cysteine proteinase 0.0274 0.3278 0.488
Toxoplasma gondii exonuclease III APE 0.0019 0.0093 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0159 0.0394
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0159 0.0394
Trypanosoma brucei prefoldin subunit, putative 0.0063 0.0632 0.0977
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0024 0.0033
Brugia malayi Cathepsin L-like cysteine proteinase 0.0019 0.009 0.01
Mycobacterium tuberculosis Probable dehydrogenase 0.0097 0.1066 0.1245
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0121 0.0273
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0306 0.0429
Echinococcus multilocularis dynamin 0.0022 0.0121 0.0121
Echinococcus granulosus dynamin 0.0022 0.0121 0.0164
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0231 0.0311
Loa Loa (eye worm) glutaminase 2 0.0266 0.3167 0.4266
Trichomonas vaginalis inositol monophosphatase, putative 0.0015 0.0041 0.0018
Plasmodium vivax importin-beta 2, putative 0.0057 0.0557 0.458
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0085 0.0079
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.0015 0.0041 0.0009
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0055 0.0533 0.0821
Trichomonas vaginalis ran, putative 0.0042 0.0371 0.1071
Trypanosoma cruzi prefoldin subunit, putative 0.0063 0.0632 0.0944
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0093 0.0126
Brugia malayi calpain 5 0.0026 0.0169 0.0218
Schistosoma mansoni hypothetical protein 0.0014 0.0024 0.0033
Toxoplasma gondii subtilisin SUB4 0.0017 0.0062 0.0056
Onchocerca volvulus 0.0025 0.0159 0.0213
Trichomonas vaginalis dynamin, putative 0.0022 0.0121 0.0274
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.1422 0.1897
Echinococcus multilocularis glycoprotein Antigen 5 0.0014 0.0024 0.0024
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0017 0.0062 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0738 0.1145
Trichomonas vaginalis interferon-induced GTP-binding protein mx, putative 0.0022 0.0121 0.0274
Entamoeba histolytica hypothetical protein, conserved 0.0055 0.0533 0.3029
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0234 0.0234
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0059 0.0079
Loa Loa (eye worm) hypothetical protein 0.003 0.0231 0.0281
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.1097 0.1484
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.0121 0.0121
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0055 0.0533 0.3029
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0004
Onchocerca volvulus 0.0106 0.1175 0.1819
Trypanosoma cruzi oligopeptidase b 0.0207 0.2436 0.3801
Echinococcus granulosus dynamin 1 protein 0.0022 0.0121 0.0164
Leishmania major cathepsin L-like protease 0.0025 0.0159 0.0195
Mycobacterium tuberculosis Probable monophosphatase 0.0015 0.0041 0.0007
Leishmania major importin beta-1 subunit, putative 0.0046 0.0424 0.0615
Plasmodium vivax vivapain-2 0.0025 0.0159 0.1082
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0183 0.0235
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0231 0.0231
Toxoplasma gondii thioredoxin reductase 0.0043 0.0383 0.0564
Mycobacterium leprae conserved hypothetical protein 0.0106 0.1175 0.4735
Loa Loa (eye worm) hypothetical protein 0.0043 0.0394 0.0502
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0121 0.0273
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0995 0.1346
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Schistosoma mansoni hypothetical protein 0.0508 0.6199 0.8385
Giardia lamblia Alanyl dipeptidyl peptidase 0.0055 0.0533 0.5115
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0025 0.0159 0.0183
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0059 0.0037
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0022 0.0121 0.0273
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.003 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0557 0.0826
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Trypanosoma brucei prolyl endopeptidase 0.052 0.6351 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0106 0.1175 0.3638
Loa Loa (eye worm) DR-78 0.0014 0.003 0.0008
Schistosoma mansoni furin-1 (S08 family) 0.0017 0.0062 0.0084
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0231 0.0313
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0022 0.0121 0.0135
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0024 0.0033
Toxoplasma gondii subtilisin SUB1 0.0017 0.0062 0.0056
Loa Loa (eye worm) hypothetical protein 0.0054 0.053 0.0687
Schistosoma mansoni hypothetical protein 0.0604 0.7393 1
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0055 0.0533 0.0821
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0231 0.0313
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0159 0.0394
Mycobacterium ulcerans inositol-monophosphatase ImpA 0.0015 0.0041 0.0025
Onchocerca volvulus 0.0106 0.1175 0.1819
Plasmodium vivax dynamin protein, putative 0.0022 0.0121 0.0754
Schistosoma mansoni Mername-AA248 (C02 family) 0.0036 0.0306 0.0414
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.0738 0.1113
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0183 0.13
Loa Loa (eye worm) MBCTL1 0.0054 0.053 0.0687
Schistosoma mansoni nuclear hormone receptor 0.003 0.0231 0.0313
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0024 0.0033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Leishmania major subtilisin-like serine peptidase 0.0017 0.0062 0.0042
Echinococcus multilocularis Mastin 0.0014 0.0024 0.0024
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0085 0.0092
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0121 0.0163
Loa Loa (eye worm) hypothetical protein 0.052 0.6351 0.8586
Brugia malayi Cathepsin L-like precursor 0.0025 0.0159 0.0202
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0106 0.1175 0.1377
Toxoplasma gondii dynamin-related protein DRPA 0.0022 0.0121 0.0149
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0085 0.0085
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0035 0.0036
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0093 0.0594
Echinococcus granulosus cathepsin b 0.0274 0.3278 0.4435
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0097 0.1066 0.1245
Loa Loa (eye worm) fibroinase 0.0025 0.0159 0.0183
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0121 0.0273
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0134 0.152 0.235
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0108 0.1201 0.4845
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0085 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0231 0.0311
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0231 0.0313
Brugia malayi nuclear hormone receptor 0.0014 0.003 0.0009
Brugia malayi nuclear receptor RXR 0.0016 0.0052 0.0042
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0183 0.0248
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0995 0.1346
Schistosoma mansoni pap-inositol-14-phosphatase 0.0015 0.0041 0.0055
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative 0.0015 0.0041 0.0045
Schistosoma mansoni smdr2 0.0022 0.0121 0.0163
Trypanosoma brucei trypanothione reductase 0.0043 0.0383 0.0585
Schistosoma mansoni nuclear receptor 0.0014 0.003 0.0041
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0159 0.0394
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0024 0.0033
Trypanosoma brucei calpain-like protein, putative 0.0036 0.0306 0.0464
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0231 0.0281
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0004
Entamoeba histolytica cysteine protease, putative 0.0017 0.0059 0.011
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0557 0.086
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0159 0.0195
Loa Loa (eye worm) hypothetical protein 0.0086 0.0922 0.1218
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0022 0.0121 0.0148
Mycobacterium tuberculosis Conserved protein 0.0106 0.1175 0.1377
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0055 0.0533 0.0533
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0097 0.1066 0.1245
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0104 0.1154 0.1561
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0022 0.0121 0.0273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0159 0.0394
Loa Loa (eye worm) prolyl oligopeptidase 0.0055 0.0533 0.069
Plasmodium vivax hypothetical protein, conserved 0.0055 0.0533 0.4363
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0231 0.0231
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0093 0.007
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0059 0.011
Trichomonas vaginalis abcb9, putative 0.0022 0.0121 0.0273
Echinococcus granulosus cathepsin l cysteine peptidase 0.0025 0.0159 0.0215
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0548 0.6692 0.9053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0738 0.1145
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0093 1
Leishmania major hypothetical protein, conserved 0.0106 0.1175 0.1804
Toxoplasma gondii ABC1 family protein 0.0106 0.1175 0.1815
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.0383 0.3054
Leishmania major oligopeptidase b 0.0207 0.2436 0.3801
Plasmodium falciparum subtilisin-like protease 2 0.0017 0.0062 0.0449
Entamoeba histolytica hypothetical protein 0.0111 0.1236 0.7361
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0533 0.0787
Onchocerca volvulus Cathepsin L homolog 0.0025 0.0159 0.0213
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0159 0.0394
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0371 0.5623
Onchocerca volvulus Cathepsin F homolog 0.0025 0.0159 0.0213
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0159 0.0394
Giardia lamblia Alanyl dipeptidyl peptidase 0.0055 0.0533 0.5115
Brugia malayi Subtilase family protein 0.0548 0.6692 1
Loa Loa (eye worm) prolyl oligopeptidase 0.0055 0.0533 0.069
Loa Loa (eye worm) hypothetical protein 0.0022 0.0121 0.0131
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.1175 0.3638
Brugia malayi glutathione reductase 0.0043 0.0383 0.0539
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0234 0.0316
Trichomonas vaginalis set domain proteins, putative 0.0237 0.2816 0.8877
Plasmodium vivax vivapain-3 0.0017 0.0059 0.0205
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Entamoeba histolytica P-glycoprotein-2 0.0022 0.0121 0.0492
Echinococcus multilocularis calpain family protein 1, d 0.0071 0.074 0.074
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0121 0.0273
Schistosoma mansoni ran 0.0042 0.0371 0.0501
Leishmania major myo-inositol-1 phosphatase, putative 0.0015 0.0041 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0159 0.0394
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0015 0.0039 0.0012
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0093 0.0184
Leishmania major cathepsin L-like protease 0.0071 0.0738 0.1113
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0394 0.0602
Plasmodium vivax prefoldin subunit 6, putative 0.0063 0.0632 0.5235
Loa Loa (eye worm) cathepsin B 0.0093 0.1007 0.1334
Trypanosoma brucei antigen, putative 0.0036 0.0306 0.0464
Onchocerca volvulus 0.0014 0.0027 0.0005
Schistosoma mansoni hypothetical protein 0.0057 0.0557 0.0753
Onchocerca volvulus 0.0017 0.0062 0.006
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.013 0.1474 0.5985
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0059 0.0037
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.013 0.1474 0.1739
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0062 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0062 0.0085
Loa Loa (eye worm) hypothetical protein 0.0057 0.0557 0.0724
Onchocerca volvulus Prolyl endopeptidase homolog 0.052 0.6351 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0059 0.0037
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0093 0.0128
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0104 0.1154 0.1561
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0085 0.0115
Schistosoma mansoni nuclear receptor 0.0014 0.003 0.0041
Brugia malayi conserved hypotetical protein 0.0014 0.003 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0059 0.0075
Brugia malayi mbt repeat family protein 0.0048 0.0448 0.0635
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0025 0.0159 0.2067
Brugia malayi Protein kinase domain containing protein 0.0057 0.0557 0.0799
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0014 0.0024 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0224 0.0304
Trypanosoma cruzi prefoldin subunit, putative 0.0063 0.0632 0.0944
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0121 0.0163
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0121 0.0273

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 289.6 nM Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icilin-challenge measured after 4 mins by liquid scintillation counting analysis ChEMBL. 24055075

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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