Detailed information for compound 1797926

Basic information

Technical information
  • TDR Targets ID: 1797926
  • Name: methyl (1R,2R,4S)-4-[(2R,4S,5S,6S)-4-dimethyl amino-5-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl -2,5,7-trihydroxy-6,11-dioxo-3,4-dihydro-1H-t etracene-1-carboxylate hydrochloride
  • MW: 606.061 | Formula: C30H36ClNO10
  • H donors: 4 H acceptors: 7 LogP: 3.86 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)[C@@H]1c2cc3c(c(c2[C@H](C[C@]1(O)CC)O[C@@H]1O[C@@H](C)[C@H]([C@H](C1)N(C)C)O)O)C(=O)c1c(C3=O)cccc1O.Cl
  • InChi: 1S/C30H35NO10.ClH/c1-6-30(38)12-19(41-20-11-17(31(3)4)25(33)13(2)40-20)22-15(24(30)29(37)39-5)10-16-23(28(22)36)27(35)21-14(26(16)34)8-7-9-18(21)32;/h7-10,13,17,19-20,24-25,32-33,36,38H,6,11-12H2,1-5H3;1H/t13-,17-,19-,20-,24-,25+,30+;/m0./s1
  • InChiKey: KTSRCTOUNGGQEI-RHYYRQJGSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl (1R,2R,4S)-4-[(2R,4S,5S,6S)-4-dimethylamino-5-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate hydrochloride
  • (1R,2R,4S)-4-[[(2R,4S,5S,6S)-4-dimethylamino-5-hydroxy-6-methyl-2-tetrahydropyranyl]oxy]-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylic acid methyl ester hydrochloride
  • (1R,2R,4S)-4-[(2R,4S,5S,6S)-4-dimethylamino-5-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-2-ethyl-2,5,7-trihydroxy-6,11-diketo-3,4-dihydro-1H-tetracene-1-carboxylic acid methyl ester hydrochloride
  • methyl (1R,2R,4S)-4-[(2R,4S,5S,6S)-4-dimethylamino-5-hydroxy-6-methyl-oxan-2-yl]oxy-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate hydrochloride
  • J Antibiotics 30:88(1977)
  • SPECTRUM200022

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Trichomonas vaginalis centaurin beta, putative 0.0048 0.0165 0.1088
Trypanosoma cruzi PH domain containing protein, putative 0.0048 0.0165 0.6469
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0011 0 0.0011
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0048 0.0165 0.6469
Schistosoma mansoni vav2 0.0048 0.0165 0.0165
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0048 0.0165 0.0165
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0004 0.0204
Trichomonas vaginalis centaurin alpha, putative 0.0048 0.0165 0.1088
Trichomonas vaginalis set domain proteins, putative 0.0235 0.0993 0.6557
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.0112 0.1272
Onchocerca volvulus Putative zinc finger protein 0.0048 0.0165 0.1659
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0009 0.0091
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0084 0.0084
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0112 0.0252
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0165 0.8353
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0048 0.0165 0.0165
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0165 0.1088
Echinococcus multilocularis cpg binding protein 0.0037 0.0112 0.0112
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Entamoeba histolytica deoxycytidyl transferase, putative 0.0037 0.0112 0.074
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0004 0.0009
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0051 0.0114
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000043743 0.00000000028885
Echinococcus multilocularis oxysterol binding protein 9 0.0048 0.0165 0.0165
Schistosoma mansoni hypothetical protein 0.0048 0.0165 0.0165
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0048 0.0165 0.0165
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0112 0.0112
Schistosoma mansoni inositol monophosphatase 0.0037 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0051 0.0334
Entamoeba histolytica hypothetical protein 0.0048 0.0165 0.1088
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0051 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0121 0.0801
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0004 0.0004
Brugia malayi CHD4 protein 0.0013 0.0009 0.002
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0051 0.0334
Entamoeba histolytica protein kinase, putative 0.0056 0.0197 0.1302
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.006 0.0215 0.0215
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0048 0.0165 0.0165
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0045 0.0147 0.6529
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0048 0.0165 0.1088
Brugia malayi Inositol-1 0.0037 0.0112 0.0252
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0004 0.0041
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0048 0.0165 0.1088
Schistosoma mansoni inositol monophosphatase 0.0037 0.0112 0.0112
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0084 0.3224
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0056 0.0197 0.7746
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0004 0.0009
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Trypanosoma cruzi DNA polymerase kappa, putative 0.0069 0.0254 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0109 0.4263
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0121 0.08
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0137 0.5238
Schistosoma mansoni hypothetical protein 0.0494 0.2139 0.2139
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0048 0.0165 0.8353
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0056 0.0056
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0109 0.0717
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0004 0.0004
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0004 0.0004
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0024 0.0056 0.2842
Echinococcus multilocularis Pleckstrin y 0.0048 0.0165 0.0165
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0714 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0037 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0286 0.1216 0.1216
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1514 1
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.13 0.8584
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0004 0.0041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0004 0.0004
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0004 0.0004
Schistosoma mansoni ferritin light chain 0.0017 0.0024 0.0024
Trypanosoma cruzi PH domain containing protein, putative 0.0048 0.0165 0.6469
Echinococcus multilocularis beta adrenergic receptor kinase 0.2267 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0004 0.0004
Onchocerca volvulus 0.0048 0.0165 0.1659
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0004 0.0004
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0137 0.695
Schistosoma mansoni cpg binding protein 0.0035 0.0104 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0254 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Trypanosoma brucei rac serine-threonine kinase, putative 0.0056 0.0197 0.7746
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0109 0.0717
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0056 0.2473
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0004 0.0009
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0084 0.0084
Brugia malayi hypothetical protein 0.0048 0.0165 0.037
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0004 0.0004
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0226 0.3157
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0165 0.1088
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0009
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0112 0.074
Schistosoma mansoni cpg binding protein 0.0037 0.0112 0.0112
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0024 0.0135
Onchocerca volvulus Protein melted homolog 0.0048 0.0165 0.1659
Schistosoma mansoni zinc finger protein 0.0048 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0056 0.0126
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.0665 0.1493
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0051 0.2248
Schistosoma mansoni hypothetical protein 0.0048 0.0165 0.0165
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0056 0.0126
Onchocerca volvulus Huntingtin homolog 0.0121 0.0488 0.4911
Echinococcus multilocularis chromobox protein 1 0.0069 0.0256 0.0256
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0004 0.0004
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0048 0.0165 0.0165
Schistosoma mansoni serine/threonine-protein kinase 0.0056 0.0197 0.0197
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0004 0.0041
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0148 0.0977
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.13 0.8584
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0151 0.0151
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0048 0.0165 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Echinococcus granulosus axis inhibition protein axin 0.0305 0.13 0.13
Echinococcus granulosus oxysterol binding protein 1 0.0048 0.0165 0.0165
Trypanosoma cruzi hypothetical protein 0.0048 0.0165 0.6469
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.0262 1
Echinococcus granulosus dna polymerase kappa 0.0069 0.0254 0.0254
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0051 0.5
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0019 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0048 0.0165 0.0165
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0004 0.0004
Trypanosoma cruzi hypothetical protein 0.0048 0.0165 0.6469
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0035 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Entamoeba histolytica protein kinase, putative 0.0056 0.0197 0.1302
Onchocerca volvulus 0.0048 0.0165 0.1659
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0056 0.0197 0.7746
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0151 0.0151
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0048 0.0165 0.0165
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0048 0.0165 0.0165
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0009 0.006
Echinococcus granulosus calcium dependent secretion activator 1 0.0048 0.0165 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0143 0.56
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.000000000043743 0.0000000016722
Echinococcus multilocularis dna polymerase kappa 0.0069 0.0254 0.0254
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0165 0.1088
Trypanosoma brucei unspecified product 0.0061 0.0219 0.8611
Trypanosoma cruzi DNA polymerase kappa, putative 0.0069 0.0254 1
Echinococcus granulosus Regulator of G protein signaling 20 0.0305 0.13 0.13
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0112 0.4398
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0004 0.0004
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0051 0.1948
Plasmodium vivax hypothetical protein, conserved 0.0011 0.000000000043743 0.0000000022185
Trichomonas vaginalis kinesin light chain, putative 0.0048 0.0165 0.1088
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0165 0.1088
Schistosoma mansoni cpg binding protein 0.0037 0.0112 0.0112
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0137 0.5238
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0048 0.0165 0.1088
Toxoplasma gondii AtPH1 family protein 0.0048 0.0165 0.6296
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0151 0.0151
Brugia malayi MAX-1A 0.0048 0.0165 0.037
Trypanosoma brucei DNA polymerase IV, putative 0.0069 0.0254 1
Echinococcus granulosus ferritin 0.0017 0.0024 0.0024
Brugia malayi PH domain containing protein 0.0048 0.0165 0.037
Leishmania major protein kinase, putative 0.0056 0.0197 0.8735
Trichomonas vaginalis protein transport protein sec7, putative 0.0048 0.0165 0.1088
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.1514 1
Entamoeba histolytica hypothetical protein 0.0048 0.0165 0.1088
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0004 0.0009
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0002 0.0002
Loa Loa (eye worm) acetyltransferase 0.0144 0.0586 0.0586
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0037 0.0112 0.0112
Onchocerca volvulus 0.0035 0.0104 0.1044
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0004 0.0004
Trichomonas vaginalis ferritin, putative 0.0017 0.0024 0.0161
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0305 0.13 0.13
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0309 0.0694
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.3644 0.3644
Echinococcus granulosus regulator of G protein signaling 3 0.0305 0.13 0.13
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0048 0.0165 0.6469
Leishmania major DNA polymerase eta, putative 0.0037 0.0112 0.4962
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.000000000043743 0.000000000043743
Trichomonas vaginalis protein transport protein sec7, putative 0.0048 0.0165 0.1088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0004 0.0004
Brugia malayi Heterochromatin protein 1 0.0069 0.0256 0.0574
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0084 0.0084
Trypanosoma cruzi hypothetical protein 0.0048 0.0165 0.6469
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0048 0.0165 0.1088
Schistosoma mansoni myotubularin-related protein 0.0048 0.0165 0.0165
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0109 0.0717
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0148 0.6549
Schistosoma mansoni ferritin 0.0017 0.0024 0.0024
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0051 0.038
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0002 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1514 1
Trypanosoma brucei PH domain containing protein, putative 0.0048 0.0165 0.6469
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0109 0.0717
Schistosoma mansoni terminal deoxycytidyl transferase 0.0037 0.0112 0.0112
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0148 0.5807
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0151 0.0338
Loa Loa (eye worm) syntrophin-1 0.0048 0.0165 0.0165
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Brugia malayi Cadps2 protein 0.0048 0.0165 0.037
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.0056 0.0056
Echinococcus granulosus expressed protein 0.0017 0.0024 0.0024
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0004 0.0009
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0048 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0009 0.0345
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0056 0.0197 0.7538
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0051 0.071
Schistosoma mansoni hypothetical protein 0.0048 0.0165 0.0165
Echinococcus granulosus Rho GTPase activating protein 24 0.0048 0.0165 0.0165
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0048 0.0165 0.0165
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0004 0.0147
Schistosoma mansoni DNA helicase recq1 0.0024 0.0056 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.13 0.8584
Loa Loa (eye worm) PH domain-containing protein 0.0048 0.0165 0.0165
Loa Loa (eye worm) AGC/AKT protein kinase 0.0056 0.0197 0.0197
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0004 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0035 0.023
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0004 0.0009
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0112 0.0112
Schistosoma mansoni ap endonuclease 0.0023 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.000000000043743 0.000000000098203
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.000000000043743 0.000000000043743
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.0586 0.1316
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0051 0.0385
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0004 0.0027
Entamoeba histolytica PH domain containing protein kinase, putative 0.0056 0.0197 0.1302
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0305 0.13 0.8584
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0056 0.0197 0.1302
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0011 0 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.13 0.8584
Echinococcus granulosus axis inhibition protein axin 0.0305 0.13 0.13
Onchocerca volvulus 0.0235 0.0993 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0051 0.0705
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0097 0.3809
Schistosoma mansoni apoferritin-2 0.0017 0.0024 0.0024
Brugia malayi Pre-SET motif family protein 0.0207 0.0867 0.1946
Brugia malayi Regulator of G protein signaling domain containing protein 0.0305 0.13 0.2919
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0112 0.4959
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Echinococcus multilocularis actin binding protein anillin 0.0048 0.0165 0.0165
Brugia malayi ecdysteroid receptor 0.0012 0.0004 0.0009
Onchocerca volvulus 0.0093 0.0364 0.3661
Schistosoma mansoni syntrophin 0.0048 0.0165 0.0165
Brugia malayi hypothetical protein 0.0305 0.13 0.2919
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0148 0.0977
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0048 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0048 0.0165 0.0165
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0056 0.0197 0.8735
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0134 0.0887
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0165 0.1088
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0004 0.0009
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0121 0.6159
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0254 1
Entamoeba histolytica hypothetical protein 0.0023 0.0051 0.0337
Loa Loa (eye worm) hypothetical protein 0.0081 0.0309 0.0309
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.0056 0.0056
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0056 0.0197 0.7746
Echinococcus multilocularis pleckstrin y domain containing family A 0.0048 0.0165 0.0165
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0051 0.2233
Trichomonas vaginalis alpha chimerin, putative 0.0048 0.0165 0.1088
Echinococcus granulosus oxysterol binding protein 9 0.0048 0.0165 0.0165
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0109 0.0717
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0148 0.0977
Leishmania major hypothetical protein, conserved 0.0048 0.0165 0.7295
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0665 0.0665
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.1514 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0712 0.3104 0.6969
Echinococcus granulosus cytohesin 1 0.0048 0.0165 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0254 1
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1216 0.1216
Echinococcus granulosus dna polymerase eta 0.0037 0.0112 0.0112
Entamoeba histolytica PH domain containing protein 0.0048 0.0165 0.1088
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0056 0.037
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0254 1
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Echinococcus multilocularis DCC interacting protein 13 beta 0.0048 0.0165 0.0165
Echinococcus multilocularis Ras associated and pleckstrin y 0.0048 0.0165 0.0165
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.0056 0.0056
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0056 0.0197 0.7746
Schistosoma mansoni ferritin light chain 0.0017 0.0024 0.0024
Trypanosoma brucei DNA polymerase IV, putative 0.0069 0.0254 1
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0000000054881 0.0000000054881
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Echinococcus granulosus GRB2 associated binding protein 3 0.0048 0.0165 0.0165
Echinococcus multilocularis dna polymerase eta 0.0037 0.0112 0.0112
Trichomonas vaginalis centaurin gamma, putative 0.0048 0.0165 0.1088
Schistosoma mansoni serine/threonine protein kinase 0.2267 1 1
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0148 0.0148
Schistosoma mansoni serine/threonine protein kinase 0.2267 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0109 0.0717
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0056 0.0197 0.8735
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000043743 0.00000000028885
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0051 0.198
Onchocerca volvulus outspread protein homolog 0.0048 0.0165 0.1659
Loa Loa (eye worm) RecQ helicase 0.0024 0.0056 0.0056
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0219 0.8611
Loa Loa (eye worm) hypothetical protein 0.0039 0.0121 0.0121
Plasmodium falciparum calcium-dependent protein kinase 7 0.0056 0.0197 1
Trypanosoma brucei unspecified product 0.0025 0.0062 0.242
Entamoeba histolytica hypothetical protein 0.0048 0.0165 0.1088
Echinococcus multilocularis oxysterol binding protein 3 0.0048 0.0165 0.0165
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0004 0.0004
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.1514 1
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0002 0.0013
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0051 0.0311
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0056 0.037
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.2139 0.2139
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0112 0.4284
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0256 0.1689
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0148 0.0148
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0309 0.0309
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0056 0.037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0051 0.0332
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0109 0.4263
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0148 0.5807
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Onchocerca volvulus 0.0048 0.0165 0.1659
Trypanosoma cruzi NIMA-related kinase, putative 0.0056 0.0197 0.7746
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0165 0.1088
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0048 0.0165 0.0165
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0665 0.0665
Schistosoma mansoni coup transcription factor 0.0012 0.0004 0.0004
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0048 0.0165 0.0165
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.0665 0.0665
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0215 0.0215
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0004 0.0004
Entamoeba histolytica PH domain containing protein kinase, putative 0.0056 0.0197 0.1302
Echinococcus granulosus Pleckstrin y 0.0048 0.0165 0.0165
Trypanosoma cruzi PH domain containing protein, putative 0.0048 0.0165 0.6469
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0137 0.0905
Echinococcus granulosus tumor protein p63 0.0408 0.1759 0.1759
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0004 0.0004
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0226 0.0226
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0009 0.006
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Schistosoma mansoni hypothetical protein 0.0058 0.0208 0.0208
Schistosoma mansoni oxysterol-binding protein 1 0.0048 0.0165 0.0165
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0004 0.0154
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0004 0.0004
Echinococcus granulosus cpg binding protein 0.0037 0.0112 0.0112
Trypanosoma cruzi Protein kinase B 0.0056 0.0197 0.7746
Entamoeba histolytica hypothetical protein 0.0048 0.0165 0.1088
Echinococcus granulosus Pleckstrin y 0.0048 0.0165 0.0165
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0148 0.0148
Schistosoma mansoni axis inhibition protein axin 0.0305 0.13 0.13
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0009 0.0009
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0048 0.0165 0.0165
Schistosoma mansoni chromobox protein 0.0069 0.0256 0.0256
Onchocerca volvulus 0.0042 0.0134 0.1353
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Echinococcus granulosus DCC interacting protein 13 beta 0.0048 0.0165 0.0165
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.0586 0.0586
Schistosoma mansoni oxysterol-binding protein 1 0.0048 0.0165 0.0165
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0051 0.1948
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0051 0.2567
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0062 0.0226 0.2918
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Entamoeba histolytica protein kinase, putative 0.0056 0.0197 0.1302
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0036 0.1361
Onchocerca volvulus 0.0058 0.0208 0.2096
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0056 0.0197 0.7746
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0165 0.1088
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0109 0.4153
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0048 0.0165 0.1088
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Schistosoma mansoni chromobox protein 0.0069 0.0256 0.0256
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0109 0.0717
Brugia malayi polk-prov protein 0.0043 0.0143 0.032
Schistosoma mansoni rho gtpase activating protein 0.0048 0.0165 0.0165
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0009 0.006
Schistosoma mansoni serine/threonine protein kinase 0.1016 0.4454 0.4454
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0112 0.074
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0056 0.2842
Schistosoma mansoni ferritin 0.0017 0.0024 0.0024
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1016 0.4454 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0004 0.0009
Mycobacterium ulcerans DNA polymerase IV 0.0069 0.0254 0.356
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Schistosoma mansoni regulator of G protein signaling 0.0305 0.13 0.13
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0165 0.037
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0254 1
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0048 0.0165 0.1088
Onchocerca volvulus 0.003 0.0084 0.0849
Schistosoma mansoni alpha-glucosidase 0.0139 0.0565 0.0565
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0109 0.0717
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Schistosoma mansoni alpha glucosidase 0.0036 0.0109 0.0109
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0048 0.0165 0.1088
Brugia malayi Oxysterol binding protein 0.0048 0.0165 0.037
Loa Loa (eye worm) PXA domain-containing protein 0.0305 0.13 0.13
Echinococcus granulosus Pleckstrin y 0.0048 0.0165 0.0165
Echinococcus granulosus G protein coupled receptor kinase 1 0.1963 0.865 0.865
Entamoeba histolytica PH domain containing protein 0.0048 0.0165 0.1088
Trypanosoma brucei glucosidase, putative 0.0036 0.0109 0.4263
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0048 0.0165 0.1659
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0112 0.44
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0104 0.0104
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0121 0.1222
Toxoplasma gondii phosphatidylinositol transfer protein 0.0048 0.0165 0.6296
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0009 0.002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1514 1
Plasmodium vivax SET domain protein, putative 0.003 0.0084 0.4277
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0256 0.1689
Brugia malayi A-kinase anchor protein 10, precursor 0.0305 0.13 0.2919
Brugia malayi probable spectrin beta chain 0.0048 0.0165 0.037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0035 0.023
Brugia malayi Dynamin 0.0048 0.0165 0.037
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0051 0.0309
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000043743 0.00000000028885
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0035 0.023
Entamoeba histolytica PH domain containing protein kinase, putative 0.0056 0.0197 0.1302
Brugia malayi PH domain containing protein 0.0048 0.0165 0.037
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0109 0.0244
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Echinococcus multilocularis axis inhibition protein axin 0.0305 0.13 0.13
Schistosoma mansoni growth factor receptor-bound protein 0.0048 0.0165 0.0165
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Echinococcus granulosus serine/threonine protein kinase 0.0056 0.0197 0.0197
Trichomonas vaginalis hypothetical protein 0.0048 0.0165 0.1088
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0051 0.2585
Echinococcus multilocularis beta 1 syntrophin 0.0048 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0004 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0069 0.0254 1
Onchocerca volvulus 0.0081 0.0309 0.3113
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0004 0.0004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0004 0.0004
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000043743 0.00000000028885
Leishmania major protein kinase, putative 0.0056 0.0197 0.8735
Brugia malayi Protein kinase domain containing protein 0.0056 0.0197 0.0443
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0056 0.2193
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0048 0.0165 0.0165
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0048 0.0165 0.037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1514 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0309 0.0309
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1514 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0035 0.023
Entamoeba histolytica p21-activated kinase 0.0056 0.0197 0.1302
Brugia malayi PH domain containing protein 0.0048 0.0165 0.037
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0004 0.0004
Brugia malayi Pre-SET motif family protein 0.003 0.0084 0.0189
Echinococcus multilocularis GRB2 associated binding protein 3 0.0048 0.0165 0.0165
Brugia malayi Dynamin 0.0048 0.0165 0.037
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0004 0.0009
Echinococcus multilocularis axis inhibition protein axin 0.0305 0.13 0.13
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000043743 0.00000000028885
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0048 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0305 0.13 0.13
Schistosoma mansoni ferritin 0.0017 0.0024 0.0024
Echinococcus multilocularis Chromo domain 0.0011 0.000000000043743 0.000000000043743
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1514 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0004 0.0004
Schistosoma mansoni ap endonuclease 0.0023 0.0051 0.0051
Echinococcus multilocularis regulator of G protein signaling 7 0.0305 0.13 0.13
Trypanosoma cruzi hypothetical protein 0.0048 0.0165 0.6469
Brugia malayi PH domain containing protein 0.0048 0.0165 0.037
Brugia malayi CXXC zinc finger family protein 0.0035 0.0104 0.0233
Schistosoma mansoni hypothetical protein 0.0048 0.0165 0.0165
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0048 0.0165 0.1088
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0048 0.0165 0.8353
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0048 0.0165 0.1088
Brugia malayi Syntrophin-1 0.0048 0.0165 0.037
Toxoplasma gondii protein kinase domain-containing protein 0.0056 0.0197 0.7538
Brugia malayi PXA domain containing protein 0.0305 0.13 0.2919
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0056 0.0197 0.7746
Onchocerca volvulus Huntingtin homolog 0.0121 0.0488 0.4911
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0084 0.0084
Leishmania major folate/biopterin transporter, putative 0.0056 0.0197 0.8735
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0019 0.0123
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0051 0.2993
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0109 0.0109
Echinococcus multilocularis pdz domain containing protein 0.0048 0.0165 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Echinococcus granulosus dnaJ subfamily B 0.0494 0.2139 0.2139
Trypanosoma brucei protein kinase, putative 0.0056 0.0197 0.7746
Schistosoma mansoni alpha-glucosidase 0.0139 0.0565 0.0565
Echinococcus granulosus Oxysterol binding protein 11 0.0048 0.0165 0.0165
Echinococcus multilocularis regulator of G protein signaling 0.0305 0.13 0.13
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0056 0.2142
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0037 0.0112 0.0112
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0134 0.0134
Echinococcus multilocularis G protein coupled receptor kinase 1 0.1963 0.865 0.865
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0002 0.0002
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0165 0.1088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0051 0.198
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0051 0.1994
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0004 0.0004
Trypanosoma cruzi NIMA-related kinase, putative 0.0056 0.0197 0.7746
Mycobacterium ulcerans DNA polymerase IV 0.0069 0.0254 0.356
Toxoplasma gondii Oxysterol-binding protein 0.0048 0.0165 0.6296
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0051 0.071
Onchocerca volvulus 0.0048 0.0165 0.1659
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.1514 1
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Loa Loa (eye worm) hypothetical protein 0.0121 0.0488 0.0488
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0712 0.3104 0.3104
Schistosoma mansoni hypothetical protein 0.0011 0.000000000043743 0.000000000043743
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0004 0.0009
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0004 0.0004
Echinococcus multilocularis calcium dependent secretion activator 1 0.0048 0.0165 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0112 1
Loa Loa (eye worm) RGS-3 protein 0.0305 0.13 0.13
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0226 0.3157
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0147 0.579
Onchocerca volvulus 0.0048 0.0165 0.1659
Brugia malayi nuclear receptor NHR-88 0.0012 0.0004 0.0009
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0069 0.0254 0.168
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0004 0.0009
Schistosoma mansoni serine/threonine-protein kinase 0.0056 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0305 0.13 0.13
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0004 0.0009
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0048 0.0165 0.8353
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0097 0.3809
Schistosoma mansoni centaurin alpha 0.0048 0.0165 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0071 0.0471
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0048 0.0165 0.0165
Trichomonas vaginalis centaurin/arf, putative 0.0048 0.0165 0.1088
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0004 0.0004
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.0056 0.0056
Schistosoma mansoni regulator of G protein signaling 0.0305 0.13 0.13
Entamoeba histolytica hypothetical protein 0.0305 0.13 0.8584
Trypanosoma cruzi hypothetical protein 0.0048 0.0165 0.6469
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0056 0.0197 0.7746
Loa Loa (eye worm) hypothetical protein 0.0305 0.13 0.13
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.0568 0.0568
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0009 0.0345
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0004 0.0004
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0009 0.0345
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0712 0.3104 0.3104
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0009 0.006
Schistosoma mansoni survival motor neuron protein 0.0058 0.0208 0.0208
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0048 0.0165 0.037
Brugia malayi chromobox protein homolog 3 0.0039 0.0121 0.0272
Leishmania major hypothetical protein, conserved 0.0048 0.0165 0.7295
Echinococcus granulosus myotubularin protein 13 0.0048 0.0165 0.0165
Trypanosoma cruzi hypothetical protein 0.0048 0.0165 0.6469
Schistosoma mansoni dynamin 0.0048 0.0165 0.0165
Entamoeba histolytica PH domain containing protein kinase, putative 0.0056 0.0197 0.1302
Schistosoma mansoni DNA helicase recq5 0.0024 0.0056 0.0056
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0009 0.006
Brugia malayi hypothetical protein 0.0121 0.0488 0.1095
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0004 0.0009
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0009 0.006
Loa Loa (eye worm) Plekhf2 protein 0.0048 0.0165 0.0165
Entamoeba histolytica protein kinase, putative 0.0056 0.0197 0.1302
Echinococcus multilocularis Pleckstrin y 0.0048 0.0165 0.0165
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0137 0.0137
Schistosoma mansoni ferritin 0.0017 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0011 0.000000000043743 0.000000000043743
Schistosoma mansoni z-protein (S1r protein) 0.0305 0.13 0.13
Trypanosoma cruzi DNA polymerase kappa, putative 0.0069 0.0254 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0035 0.023
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0056 0.0126
Brugia malayi PH domain containing protein 0.0048 0.0165 0.037
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0112 0.074
Brugia malayi steroid hormone receptor 0.0012 0.0004 0.0009
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0048 0.0165 0.1659
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0004 0.0004
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0165 0.1088
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Echinococcus multilocularis chromobox protein 1 0.0069 0.0256 0.0256
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0051 0.3032
Echinococcus granulosus pdz domain containing protein 0.0048 0.0165 0.0165
Brugia malayi Cytohesin 3 0.0048 0.0165 0.037
Plasmodium vivax PH domain containing protein 0.0048 0.0165 0.8353
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0305 0.13 0.13
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0037 0.0112 0.0112
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0035 0.023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1514 1
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0165 0.1088
Schistosoma mansoni goodpasture antigen-binding protein 0.0048 0.0165 0.0165
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0867 0.0867
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0048 0.0165 0.8353
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0084 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Giardia lamblia DINP protein human, muc B family 0.0045 0.0147 0.0972
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0009 0.0009
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0048 0.0165 0.1088
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0009 0.0389
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.2267 1 1
Trypanosoma brucei unspecified product 0.0025 0.0062 0.242
Brugia malayi PH domain containing protein 0.0048 0.0165 0.037
Plasmodium falciparum DNA repair protein REV1, putative 0.0011 0 0.0014
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0009 0.006
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0148 0.0148
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0148 0.0977
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0004 0.0004
Schistosoma mansoni zinc finger protein 0.0048 0.0165 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0097 0.3809
Entamoeba histolytica protein kinase, putative 0.0056 0.0197 0.1302
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0151 0.0151
Entamoeba histolytica PH domain containing protein kinase, putative 0.0056 0.0197 0.1302
Schistosoma mansoni dynamin 0.0048 0.0165 0.0165
Loa Loa (eye worm) cytohesin 3 0.0048 0.0165 0.0165
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0137 0.0905
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0004 0.0004
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0048 0.0165 0.0165
Giardia lamblia Sgs1 DNA helicase, putative 0.0024 0.0056 0.0368
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0254 1
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.13 0.8584
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.0665 0.0665
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0004 0.0147
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0048 0.0165 0.0165
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0165 0.037
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0056 0.0197 0.7746
Brugia malayi regulator of G-protein signaling rgs-7 0.0305 0.13 0.2919
Toxoplasma gondii hypothetical protein 0.0048 0.0165 0.6296
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0056 0.2142
Echinococcus multilocularis Pleckstrin y 0.0048 0.0165 0.0165
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0009 0.0009
Echinococcus multilocularis regulator of G protein signaling 3 0.0305 0.13 0.13
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Entamoeba histolytica hypothetical protein 0.0305 0.13 0.8584
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0109 0.0717
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0305 0.13 0.13
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0134 0.0887
Echinococcus multilocularis ferritin 0.0017 0.0024 0.0024
Toxoplasma gondii exonuclease III APE 0.0023 0.0051 0.1935
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0051 0.0334
Brugia malayi PXA domain containing protein 0.0305 0.13 0.2919
Echinococcus granulosus pleckstrin y domain containing family A 0.0048 0.0165 0.0165
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0056 0.0197 0.7746
Entamoeba histolytica ARF GTPase activating protein, putative 0.0048 0.0165 0.1088
Entamoeba histolytica hypothetical protein 0.0056 0.0197 0.1302
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0002 0.0075
Loa Loa (eye worm) hypothetical protein 0.0121 0.0488 0.0488
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0112 0.4398
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0048 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0048 0.0165 0.8353
Echinococcus multilocularis rac serine:threonine kinase 0.0056 0.0197 0.0197
Echinococcus granulosus regulator of G protein signaling 7 0.0305 0.13 0.13
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Entamoeba histolytica hypothetical protein 0.0048 0.0165 0.1088
Brugia malayi follicle stimulating hormone receptor 0.0231 0.0972 0.2183
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Echinococcus granulosus bloom syndrome protein 0.0024 0.0056 0.0056
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0148 0.5807
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0208 0.0467
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1514 1
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.000000000043743 0.000000000098203
Trypanosoma cruzi PH domain containing protein, putative 0.0048 0.0165 0.6469
Echinococcus granulosus beta 1 syntrophin 0.0048 0.0165 0.0165
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0151 0.0151
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0148 0.0332
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0056 0.0197 1
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0024 0.0337
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.0586 0.0586
Schistosoma mansoni axis inhibition protein axin 0.0305 0.13 0.13
Brugia malayi Oxysterol-binding protein 0.0048 0.0165 0.037
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0048 0.0165 0.037
Loa Loa (eye worm) hypothetical protein 0.0305 0.13 0.13
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0002 0.0002
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0112 0.074
Echinococcus multilocularis regulator of G protein signaling 3 0.0305 0.13 0.13
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0051 0.2567
Leishmania major DNA polymerase kappa, putative 0.0045 0.0147 0.6529
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0051 0.198
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0226 0.0507
Echinococcus multilocularis Rho GTPase activating protein 24 0.0048 0.0165 0.0165
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0048 0.0165 0.1088
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Schistosoma mansoni DNA polymerase eta 0.0037 0.0112 0.0112
Onchocerca volvulus 0.0048 0.0165 0.1659
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0226 0.0226
Brugia malayi Pleckstrin Homology Domain 0.0048 0.0165 0.037
Schistosoma mansoni goodpasture antigen-binding protein 0.0048 0.0165 0.0165
Onchocerca volvulus 0.0012 0.0004 0.0041
Loa Loa (eye worm) oxysterol binding protein 0.0048 0.0165 0.0165
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0048 0.0165 0.0165
Trypanosoma brucei DNA polymerase eta, putative 0.0037 0.0112 0.44
Loa Loa (eye worm) rho-GTPase-activating 0.0048 0.0165 0.0165
Echinococcus granulosus chromobox protein 1 0.0069 0.0256 0.0256
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0009 0.0009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0281 0.0281
Schistosoma mansoni hypothetical protein 0.0048 0.0165 0.0165
Brugia malayi PH domain containing protein 0.0048 0.0165 0.037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0004 0.0004
Brugia malayi Plekhf2 protein 0.0048 0.0165 0.037
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0109 0.0109
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0095 0.1025
Plasmodium vivax DNA repair protein REV1, putative 0.0011 0 0.0014
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0112 0.0252
Echinococcus granulosus regulator of G protein signaling 3 0.0305 0.13 0.13
Brugia malayi hypothetical protein 0.0305 0.13 0.2919
Loa Loa (eye worm) hypothetical protein 0.0037 0.0112 0.0112
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.000000000043743 0.000000000043743
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0207 0.0207
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0056 0.037
Onchocerca volvulus 0.0011 0.0000000054881 0.000000055268
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0004 0.0004
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0004 0.0004
Echinococcus multilocularis myotubularin protein 13 0.0048 0.0165 0.0165
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0002 0.0002
Leishmania major serine/threonine-protein kinase a, putative 0.0056 0.0197 0.8735
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0048 0.0165 0.8353
Brugia malayi TBC domain containing protein 0.0048 0.0165 0.037
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0045 0.0147 0.1784
Loa Loa (eye worm) hypothetical protein 0.0043 0.0143 0.0143
Schistosoma mansoni regulator of G protein signaling 0.0305 0.13 0.13
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0048 0.0165 0.6469
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0305 0.13 0.13
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0109 0.0717
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0056 0.0197 0.7746
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0254 1
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0048 0.0165 0.0165
Toxoplasma gondii hypothetical protein 0.0048 0.0165 0.6296
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0004 0.0004
Brugia malayi regulator of G-protein signaling egl-10 0.0305 0.13 0.2919
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0009 0.006
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0109 0.0717
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0148 0.0148
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0035 0.023
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.000000000043743 0.0000000022185
Echinococcus granulosus chromobox protein 1 0.0069 0.0256 0.0256
Echinococcus multilocularis dynamin 1 0.0048 0.0165 0.0165
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0051 0.0385
Echinococcus multilocularis oxysterol binding protein 1 0.0048 0.0165 0.0165
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0051 0.2585
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0051 0.0051
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0056 0.0197 0.1302
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0084 0.0084
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Echinococcus granulosus regulator of G protein signaling 7 0.0305 0.13 0.13
Loa Loa (eye worm) hypothetical protein 0.0305 0.13 0.13
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Schistosoma mansoni regulator of G protein signaling 0.0305 0.13 0.13
Echinococcus granulosus microtubule associated protein 2 0.0833 0.3644 0.3644
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0071 0.0471
Brugia malayi nuclear hormone receptor 0.0012 0.0004 0.0009
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0009 0.006
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0305 0.13 0.13
Loa Loa (eye worm) hypothetical protein 0.0045 0.0148 0.0148
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0714 1
Echinococcus granulosus oxysterol binding protein 3 0.0048 0.0165 0.0165
Entamoeba histolytica hypothetical protein 0.0056 0.0197 0.1302
Plasmodium falciparum oxysterol-binding protein, putative 0.0048 0.0165 0.8353
Entamoeba histolytica hypothetical protein 0.0305 0.13 0.8584
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1216 0.1216
Echinococcus granulosus expressed protein 0.0305 0.13 0.13
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0062 0.0226 1
Loa Loa (eye worm) hypothetical protein 0.0305 0.13 0.13
Echinococcus multilocularis Oxysterol binding protein 11 0.0048 0.0165 0.0165
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0151 0.0151
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1016 0.4454 0.4454
Plasmodium falciparum PH domain-containing protein, putative 0.0048 0.0165 0.8353
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Echinococcus multilocularis expressed protein 0.0305 0.13 0.13
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0309 0.0309
Schistosoma mansoni regulator of G protein signaling 0.0305 0.13 0.13
Brugia malayi PH domain containing protein 0.0048 0.0165 0.037
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0712 0.3104 0.3104
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0148 0.0148
Brugia malayi SET domain containing protein 0.0013 0.0008 0.0018
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0256 0.0256
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0004 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0151 0.0151
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0004 0.0009
Entamoeba histolytica hypothetical protein 0.0011 0.000000000043743 0.00000000028885
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0056 0.0197 0.7746
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0148 0.0148
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0048 0.0165 0.1088
Echinococcus multilocularis cytohesin 1 0.0048 0.0165 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0143 0.56
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.3644 0.3644
Echinococcus granulosus Chromo domain 0.0011 0.000000000043743 0.000000000043743
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.13 0.8584
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000043743 0.00000000028885
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0121 0.0802
Echinococcus granulosus Chromobox protein 3 0.0011 0.0000000054881 0.0000000054881
Echinococcus granulosus dynamin 1 0.0048 0.0165 0.0165
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.0972 0.0972
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0254 1
Trichomonas vaginalis centaurin/arf, putative 0.0048 0.0165 0.1088
Echinococcus multilocularis expressed protein 0.0017 0.0024 0.0024
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0148 0.0975
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0109 0.4807
Onchocerca volvulus 0.006 0.0215 0.2162
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0095 0.1025
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0148 0.0148
Trichomonas vaginalis DNA polymerase eta, putative 0.0069 0.0254 0.168
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Echinococcus multilocularis Regulator of G protein signaling 20 0.0305 0.13 0.13
Echinococcus multilocularis tumor protein p63 0.0408 0.1759 0.1759
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0151 0.0151
Entamoeba histolytica protein kinase, putative 0.0056 0.0197 0.1302
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0109 0.0109
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0016 0.0107
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0056 0.0197 0.7746
Brugia malayi Uncoordinated protein 104 0.0048 0.0165 0.037
Brugia malayi PH domain containing protein 0.0048 0.0165 0.037
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0714 1
Onchocerca volvulus 0.0048 0.0165 0.1659
Echinococcus multilocularis regulator of G protein signaling 7 0.0305 0.13 0.13
Loa Loa (eye worm) uncoordinated protein 104 0.0048 0.0165 0.0165
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0112 0.1566
Entamoeba histolytica PH domain containing protein 0.0048 0.0165 0.1088
Brugia malayi hypothetical protein 0.0286 0.1216 0.2729
Entamoeba histolytica protein kinase, putative 0.0056 0.0197 0.1302
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0112 0.4398
Loa Loa (eye worm) inositol-1 0.0037 0.0112 0.0112
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0056 0.2193
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0121 0.0801
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0134 0.1353
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0076 0.0076
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0062 0.0226 0.0226
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0024 0.0337
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0004 0.0009
Brugia malayi Regulator of G protein signaling domain containing protein 0.0305 0.13 0.2919
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0305 0.13 0.13
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0012 0.0002 0.01
Trypanosoma cruzi hypothetical protein 0.0048 0.0165 0.6469
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Entamoeba histolytica PH domain containing protein kinase, putative 0.0056 0.0197 0.1302
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0056 0.0197 0.7746
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0712 0.3104 0.3104
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0254 1
Schistosoma mansoni apoferritin-2 0.0017 0.0024 0.0024

Activities

Activity type Activity value Assay description Source Reference
Inhibition (ADMET) = 70.22183588 % Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Inhibition (ADMET) = 83.90702497 % Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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