Detailed information for compound 1847881

Basic information

Technical information
  • TDR Targets ID: 1847881
  • Name: 15981-92-7
  • MW: 224.213 | Formula: C10H12N2O4
  • H donors: 1 H acceptors: 2 LogP: -0.4 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@@H]2C[C@H]1Oc1n2cc(c(=O)n1)C
  • InChi: 1S/C10H12N2O4/c1-5-3-12-8-2-6(7(4-13)15-8)16-10(12)11-9(5)14/h3,6-8,13H,2,4H2,1H3/t6-,7-,8-/m1/s1
  • InChiKey: JCSNHEYOIASGKU-BWZBUEFSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • AIDS015652
  • ZINC03956725
  • BTB 14109
  • 2,5-Methano-5H,9H-pyrimido(2,1-b)(1,5,3)dioxazepin-9-one, 2,3-dihydro-3-(hydroxymethyl)-8-methyl-
  • 2,5-Methano-5H,9H-pyrimido(2,1-b)(1,5,3)dioxazepin-9-one, 2,3-dihydro-3-(hydroxymethyl)-8-methyl-, (2R,3R,5R)-
  • 2,3'-O-Cyclothymidine
  • 2,5-Methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one, 2,3-dihydro-3-(hydroxymethyl)-8-methyl-
  • 2,5-Methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one, 2,3-dihydro-3-(hydroxymethyl)-8-methyl-, (2R,3R,5R)-
  • AHT
  • AIDS-015652
  • NSC 144601
  • Anhydrothymidine
  • O2,3'-Cyclothymidine
  • SR-01000636602-1

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi alpha tubulin, putative 0.0033 0.0087 0.0754
Giardia lamblia PHD finger protein 15 0.0032 0.0082 0.6135
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0031 0.0261
Echinococcus granulosus c-Jun N-terminal kinases 0.0237 0.0873 0.2787
Schistosoma mansoni tubulin subunit epsilon 0.0025 0.0055 0.0175
Loa Loa (eye worm) acetyltransferase 0.0146 0.0522 0.3435
Echinococcus multilocularis tubulin alpha 1C chain 0.0033 0.0087 0.0087
Leishmania major cytochrome p450-like protein 0.0034 0.009 0.0778
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0032 0.0083 0.0719
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0032 0.0083 0.0719
Leishmania major alpha tubulin 0.0033 0.0087 0.0754
Mycobacterium ulcerans beta-lactamase 0.0038 0.0106 0.1805
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0132 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0019 0.0034 0.2483
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0032 0.0083 0.5221
Trypanosoma brucei oxidoreductase-like protein 0.0013 0.0009 0.0065
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0031 0.0203
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0009 0.0128
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0009 0.0128
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0021 0.0042 0.0698
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.003 0.0255
Leishmania major alpha tubulin 0.0033 0.0087 0.0754
Leishmania major beta tubulin 0.0025 0.0055 0.0469
Brugia malayi cell division control protein 2 homolog 0.0045 0.0132 0.0871
Mycobacterium tuberculosis Probable oxidoreductase 0.0013 0.0009 0.0084
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0317 0.2091
Brugia malayi Cytochrome P450 family protein 0.0025 0.0056 0.0369
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.003 0.0255
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0125 0.0392
Trichomonas vaginalis helicase, putative 0.0013 0.001 0.0706
Entamoeba histolytica prolyl oligopeptidase family protein 0.0032 0.0083 0.5221
Onchocerca volvulus 0.0038 0.0106 0.0701
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.003 0.0198
Brugia malayi hypothetical protein 0.0055 0.017 0.1122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0012 0.0005 0.0015
Mycobacterium ulcerans short chain dehydrogenase 0.0021 0.0042 0.0698
Schistosoma mansoni tubulin subunit beta 0.0011 0.0001 0.0003
Echinococcus granulosus cyclin B 0.0044 0.0128 0.0409
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0025 0.0056 0.0615
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0082 0.0964
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0025 0.0056 0.0615
Loa Loa (eye worm) ets-domain-containing protein 0.001 0 0.0001
Plasmodium falciparum peptidase, putative 0.0032 0.0083 0.0987
Echinococcus multilocularis beta tubulin 0.0025 0.0055 0.0055
Leishmania major alpha tubulin 0.0033 0.0087 0.0754
Trichomonas vaginalis cyclin B, putative 0.0044 0.0128 0.9689
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0031 0.026
Trypanosoma brucei alpha tubulin 0.0033 0.0087 0.0754
Echinococcus multilocularis geminin 0.034 0.1269 0.1269
Loa Loa (eye worm) hypothetical protein 0.0055 0.017 0.1122
Echinococcus multilocularis cyclins 0.0018 0.003 0.003
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0327 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0024 0.0156
Loa Loa (eye worm) D-ets-2 protein 0.001 0 0.0001
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0009 0.0128
Onchocerca volvulus 0.0044 0.0128 0.0844
Schistosoma mansoni hypothetical protein 0.0104 0.036 0.1148
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0032 0.0083 0.0266
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0042 0.0275
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0032 0.0083 0.0719
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Echinococcus granulosus cpg binding protein 0.0061 0.0195 0.0624
Echinococcus multilocularis peroxisome assembly protein 26 0.0033 0.0087 0.0087
Trichomonas vaginalis tubulin epsilon chain, putative 0.0033 0.0087 0.6577
Echinococcus granulosus Tubulin alpha 1 chain 0.0033 0.0087 0.0279
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0021 0.0042 0.1153
Echinococcus granulosus GPCR family 2 0.0048 0.0145 0.0462
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.0545 0.3585
Brugia malayi cytochrome P450 0.0025 0.0056 0.0369
Echinococcus granulosus alpha tubulin 0.0033 0.0087 0.0279
Trichomonas vaginalis tubulin alpha chain, putative 0.0014 0.0014 0.0952
Leishmania major beta tubulin 0.0025 0.0055 0.0469
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0106 0.8028
Leishmania major cyclin 0.0044 0.0128 0.1111
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.001 0.0154
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0025 0.0056 0.0615
Trichomonas vaginalis cyclins, putative 0.0044 0.0128 0.9689
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.001 0.0028
Trypanosoma brucei epsilon tubulin 0.0025 0.0055 0.0469
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.001 0.0032
Trichomonas vaginalis tubulin beta chain, putative 0.0014 0.0014 0.0952
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0025 0.0056 0.0615
Loa Loa (eye worm) cytochrome P450 0.0025 0.0056 0.0369
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.0087 0.6577
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0106 0.1262
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0031 0.026
Loa Loa (eye worm) tubulin beta-2A chain 0.0025 0.0055 0.0361
Leishmania major alpha tubulin 0.0033 0.0087 0.0754
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0079
Brugia malayi Tubulin alpha chain 0.0011 0.0001 0.0007
Echinococcus granulosus dnaJ subfamily B 0.0824 0.3133 1
Mycobacterium ulcerans short chain dehydrogenase 0.0021 0.0042 0.0698
Echinococcus multilocularis tubulin alpha chain 0.0033 0.0087 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0025 0.0056 0.0615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Leishmania major epsilon tubulin, putative 0.0025 0.0055 0.0469
Giardia lamblia Alpha-tubulin 0.0033 0.0087 0.6577
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0012 0.0005 0.0005
Onchocerca volvulus Prolyl endopeptidase homolog 0.0032 0.0083 0.0549
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0237 0.0237
Schistosoma mansoni ap endonuclease 0.0018 0.003 0.0097
Echinococcus multilocularis Tubulin beta 2C chain 0.0025 0.0055 0.0055
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.003 0.003
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0111 0.8402
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0057 0.0491
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.017 0.0535
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0081
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0521 0.4543
Trichomonas vaginalis cyclins, putative 0.0044 0.0128 0.9689
Leishmania major alpha tubulin 0.0033 0.0087 0.0754
Leishmania major alpha tubulin 0.0033 0.0087 0.0754
Leishmania major hypothetical protein, conserved 0.0038 0.0106 0.092
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0025 0.0056 0.0615
Brugia malayi Tubulin alpha-2 chain 0.0033 0.0087 0.0575
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.001 0.0154
Entamoeba histolytica tubulin gamma chain 0.0025 0.0055 0.2421
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0025 0.0056 0.0615
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0057 0.0057
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0032 0.0083 0.2524
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0317 0.0317
Plasmodium vivax beta-hydroxyacyl-ACP dehydratase precursor, putative 0.0227 0.0836 1
Echinococcus multilocularis Smad4 0.0017 0.0024 0.0024
Echinococcus granulosus cyclins 0.0018 0.003 0.0096
Loa Loa (eye worm) hypothetical protein 0.0104 0.036 0.2367
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.003 0.0199
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0706
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.009 0.0778
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0136 0.0484 0.0484
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0031 0.026
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0013 0.0009 0.0084
Echinococcus granulosus Tubulin beta 2C chain 0.0025 0.0055 0.0175
Trypanosoma cruzi prolyl endopeptidase 0.0032 0.0083 0.0719
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0014 0.0014 0.0952
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0032 0.0083 0.6276
Trichomonas vaginalis cyclin B, putative 0.0044 0.0128 0.9689
Entamoeba histolytica tubulin family protein 0.0025 0.0055 0.2421
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.001 0.0706
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.003 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.017 0.148
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0237 0.0873 0.5748
Chlamydia trachomatis 3-hydroxyacyl-ACP dehydratase 0.0227 0.0836 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0013 0.0009 0.0056
Echinococcus multilocularis prolyl endopeptidase 0.0032 0.0083 0.0083
Giardia lamblia Alanyl dipeptidyl peptidase 0.0032 0.0083 0.6276
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0009 0.0128
Loa Loa (eye worm) hypothetical protein 0.0038 0.0106 0.0701
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0009 0.0128
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0021 0.0042 0.0129
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.001 0.0066
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0013 0.0009 0.0084
Schistosoma mansoni cyclin B 0.0044 0.0128 0.0409
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0145 0.0462
Loa Loa (eye worm) cyclin domain-containing protein 0.0018 0.003 0.0198
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0079
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0013 0.0009 0.0024
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0015 0.0015
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0132 0.0871
Brugia malayi Tubulin beta chain 0.0014 0.0014 0.0089
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0083 0.0719
Plasmodium falciparum glutathione reductase 0.0013 0.001 0.0108
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0031 0.026
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0136 0.0484 0.4219
Leishmania major beta tubulin 0.0025 0.0055 0.0469
Trypanosoma cruzi cyclin, putative 0.0044 0.0128 0.1111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0317 0.0317
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0021 0.0042 0.0042
Echinococcus granulosus peroxisome assembly protein 26 0.0033 0.0087 0.0279
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.001 0.0108
Chlamydia trachomatis oxoacy-ACP reductase 0.0021 0.0042 0.0402
Schistosoma mansoni tubulin subunit alpha 0.0033 0.0087 0.0279
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0025 0.0056 0.0615
Leishmania major beta tubulin 0.0025 0.0055 0.0469
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.001 0.0108
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0082 0.0537
Trichomonas vaginalis cyclins, putative 0.0018 0.003 0.2207
Brugia malayi beta-lactamase family protein 0.0038 0.0106 0.0701
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0031 0.026
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0013 0.0009 0.0128
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0317 0.1013
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.003 0.0199
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0083 0.0987
Echinococcus multilocularis cyclin dependent kinase 5 0.0045 0.0132 0.0132
Echinococcus granulosus cyclin dependent kinase 0.0045 0.0132 0.0422
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0025 0.0056 0.0615
Brugia malayi Fli-1 protein 0.0219 0.0802 0.5281
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0057 0.0377
Mycobacterium tuberculosis Conserved protein 0.0038 0.0106 0.1177
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.003 0.0326
Leishmania major beta tubulin 0.0025 0.0055 0.0469
Echinococcus granulosus Tubulin alpha 1 chain 0.0033 0.0087 0.0279
Trypanosoma brucei pteridine reductase 1 0.0013 0.0009 0.0065
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.003 0.035
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0308 0.1146 1
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.017 0.203
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.012 0.0383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0004 0.0257
Brugia malayi Stress-activated protein kinase jnk-1 0.0237 0.0873 0.5748
Echinococcus granulosus acylamino acid releasing enzyme 0.0032 0.0083 0.0266
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0031 0.026
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0125 0.1486
Loa Loa (eye worm) hypothetical protein 0.0048 0.0145 0.0954
Onchocerca volvulus 0.0038 0.0106 0.0701
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0082 0.0254
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.001 0.0108
Echinococcus granulosus cyclins 0.0018 0.003 0.0096
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.001 0.0079
Giardia lamblia Hypothetical protein 0.0018 0.003 0.2207
Schistosoma mansoni alpha tubulin 0.0033 0.0087 0.0279
Toxoplasma gondii beta-tubulin, putative 0.0025 0.0055 0.017
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0405 0.1519 0.1519
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0025 0.0056 0.0943
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0106 0.1177
Schistosoma mansoni ets-related 0.0219 0.0802 0.256
Mycobacterium ulcerans short chain dehydrogenase 0.0021 0.0042 0.0698
Trichomonas vaginalis cyclins, putative 0.0044 0.0128 0.9689
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.017 0.203
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.0897 0.5906
Echinococcus granulosus tubulin alpha chain 0.0033 0.0087 0.0279
Entamoeba histolytica hypothetical protein, conserved 0.0032 0.0083 0.5221
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.001 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0706
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Echinococcus multilocularis tubulin beta 1 chain 0.0025 0.0055 0.0055
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.001 0.0079
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0132 0.0422
Leishmania major mitochondrial DNA polymerase beta 0.0308 0.1146 1
Leishmania major beta tubulin 0.0025 0.0055 0.0469
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0136 0.0484 0.4219
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0145 0.0954
Plasmodium falciparum alpha tubulin 2 0.0033 0.0087 0.1034
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0125 0.0399
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.0012 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.0223 0.0821 0.262
Brugia malayi Ets-domain containing protein 0.001 0 0.0001
Echinococcus granulosus peregrin 0.0035 0.0095 0.0304
Giardia lamblia Beta tubulin 0.0025 0.0055 0.4094
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0405 0.1519 0.4848
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0082 0.0082
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0032 0.0083 0.5221
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0317 0.2091
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0521 0.4543
Onchocerca volvulus Alhambra homolog 0.0032 0.0082 0.0537
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0132 1
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0106 0.1177
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.029 0.3233
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0136 0.0484 0.4219
Trichomonas vaginalis tubulin gamma chain, putative 0.0025 0.0055 0.4094
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0127 0.1097
Brugia malayi Ets-domain containing protein 0.0072 0.0237 0.1562
Trypanosoma brucei epsilon tubulin 0.0025 0.0055 0.0469
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.0521 0.4543
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0024 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0317 0.1013
Schistosoma mansoni hypothetical protein 0.034 0.1269 0.4051
Mycobacterium ulcerans oxidoreductase 0.0021 0.0042 0.0698
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0317 0.1013
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0127 0.1097
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0106 0.8028
Loa Loa (eye worm) hypothetical protein 0.0104 0.036 0.2373
Loa Loa (eye worm) hypothetical protein 0.0022 0.0046 0.0304
Loa Loa (eye worm) alpha-tubulin 0.0033 0.0087 0.0575
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0034 0.009 0.1527
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0222
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0106 0.8028
Trypanosoma cruzi oligopeptidase b 0.0032 0.0083 0.0719
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.003 0.0255
Trichomonas vaginalis cyclins, putative 0.003 0.0075 0.5631
Giardia lamblia GTOR 0.0018 0.0031 0.2266
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0031 0.0031
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.001 0.0079
Trypanosoma brucei beta tubulin 0.0025 0.0055 0.0469
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0145 0.0954
Trichomonas vaginalis cyclin D, putative 0.0018 0.003 0.2207
Loa Loa (eye worm) beta-tubulin 0.0025 0.0055 0.0361
Trichomonas vaginalis tubulin alpha chain, putative 0.0014 0.0014 0.0952
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.0358 0.1144
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0031 0.0098
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0145 0.0145
Echinococcus granulosus tubulin alpha chain 0.0033 0.0087 0.0279
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0021 0.0042 0.0698
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0125 0.9451
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0009 0.0128
Onchocerca volvulus 0.0013 0.0009 0.0056
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0308 0.1146 1
Plasmodium falciparum phd finger protein, putative 0.0032 0.0082 0.0964
Echinococcus multilocularis cyclin B 0.0044 0.0128 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Loa Loa (eye worm) hypothetical protein 0.0038 0.0106 0.0701
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0327 0.3645
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.003 0.2223
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.0358 0.0358
Echinococcus multilocularis cyclin b3 0.0018 0.003 0.003
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0025 0.0056 0.0943
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0021 0.0042 0.0488
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0025 0.0056 0.0943
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.0132 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0021 0.0042 0.0698
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0127 0.1097
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0025 0.0056 0.0943
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0057 0.0178
Trichomonas vaginalis tubulin epsilon chain, putative 0.0033 0.0087 0.6577
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.029 0.3233
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0029
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0136 0.0484 0.4219
Echinococcus granulosus Tubulin alpha 1 chain 0.0033 0.0087 0.0279
Plasmodium vivax tubulin beta chain, putative 0.0025 0.0055 0.0644
Entamoeba histolytica tubulin family protein 0.0025 0.0055 0.2421
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0013 0.0009 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0706
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0032 0.0083 0.0266
Entamoeba histolytica prolyl oligopeptidase family protein 0.0032 0.0083 0.5221
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0237 0.1562
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0107 0.0341
Schistosoma mansoni cyclins 0.0018 0.003 0.0096
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0057 0.0183
Loa Loa (eye worm) hypothetical protein 0.0038 0.0106 0.0701
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.0896 1
Loa Loa (eye worm) tubulin beta chain 0.0025 0.0055 0.0361
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0136 0.0484 0.1526
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0009 0.0128
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0045 0.0132 0.0871
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0132 1
Trypanosoma cruzi epsilon tubulin, putative 0.0025 0.0055 0.0469
Loa Loa (eye worm) BEN-1 protein 0.0025 0.0055 0.0361
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.003 0.05
Trichomonas vaginalis tubulin gamma chain, putative 0.0025 0.0055 0.4094
Schistosoma mansoni tubulin subunit beta 0.0025 0.0055 0.0175
Echinococcus multilocularis tubulin delta chain 0.0011 0.0001 0.0001
Echinococcus granulosus tubulin alpha 3 chain 0.0033 0.0087 0.0279
Schistosoma mansoni gabp alpha 0.0072 0.0237 0.0757
Echinococcus multilocularis GPCR, family 2 0.0048 0.0145 0.0145
Loa Loa (eye worm) beta-lactamase 0.0038 0.0106 0.0701
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0013 0.0009 0.0065
Schistosoma mansoni tubulin subunit gamma 0.0025 0.0055 0.0175
Mycobacterium tuberculosis Possible oxidoreductase 0.0013 0.0009 0.0084
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0079
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0136 0.0484 0.1545
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0025 0.0056 0.0615
Brugia malayi beta-tubulin, identical 0.0025 0.0055 0.0361
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0405 0.1519 1
Mycobacterium ulcerans hypothetical protein 0.0038 0.0106 0.1805
Plasmodium falciparum alpha tubulin 1 0.0033 0.0087 0.1034
Leishmania major beta tubulin 0.0025 0.0055 0.0469
Loa Loa (eye worm) tubulin beta-4 chain 0.0025 0.0055 0.0361
Echinococcus multilocularis beta tubulin 0.0025 0.0055 0.0055
Brugia malayi MH1 domain containing protein 0.0017 0.0024 0.0156
Trypanosoma brucei alpha tubulin 0.0033 0.0087 0.0754
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0025 0.0056 0.0615
Entamoeba histolytica tubulin alpha chain, putative 0.0033 0.0087 0.5607
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0012 0.0005 0.003
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.003 0.0021
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0132 1
Schistosoma mansoni tubulin subunit alpha 0.0011 0.0001 0.0003
Echinococcus granulosus cyclins 0.0018 0.003 0.0096
Schistosoma mansoni hypothetical protein 0.0025 0.0054 0.0173
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0506 0.1615
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0025 0.0056 0.0615
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0024 0.0076
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0012 0.0004 0.0029
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.001 0.0032
Leishmania major cytochrome p450-like protein 0.0025 0.0056 0.0481
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.0396 0.1247
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0706
Echinococcus multilocularis acylamino acid releasing enzyme 0.0032 0.0083 0.0083
Trichomonas vaginalis cyclin A, putative 0.0044 0.0128 0.9689
Echinococcus multilocularis cyclins 0.0018 0.003 0.003
Brugia malayi CXXC zinc finger family protein 0.0058 0.0183 0.1203
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.0585 0.6519
Plasmodium falciparum thioredoxin reductase 0.0013 0.001 0.0108
Trichomonas vaginalis tubulin, putative 0.0025 0.0055 0.4094
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0044 0.0128 0.1111
Mycobacterium tuberculosis Conserved protein 0.0038 0.0106 0.1177
Trypanosoma brucei epsilon tubulin 0.0025 0.0055 0.0469
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0025 0.0055 0.0055
Toxoplasma gondii alpha tubulin TUBA1 0.0033 0.0087 0.0273
Plasmodium falciparum enoyl-acyl carrier reductase 0.0013 0.0009 0.009
Toxoplasma gondii beta-hydroxyacyl-acyl carrier protein dehydratase (FABZ) 0.0227 0.0836 0.2638
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0012 0.0005 0.0015
Trypanosoma cruzi cyclin 6, putative 0.0044 0.0128 0.1111
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0042 0.0275
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0013 0.0009 0.0229
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0025 0.0056 0.0615
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0106 0.1805
Brugia malayi Ets-domain containing protein 0.0072 0.0237 0.1562
Trypanosoma brucei alpha tubulin 0.0033 0.0087 0.0754
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0105 0.1243
Brugia malayi Thioredoxin reductase 0.0038 0.0105 0.069
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0327 0.3645
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.017 0.203
Brugia malayi Bromodomain containing protein 0.0035 0.0095 0.0628
Toxoplasma gondii cytochrome p450 superfamily protein 0.0025 0.0056 0.0174
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0014 0.0013 0.0146
Echinococcus granulosus prolyl endopeptidase 0.0032 0.0083 0.0266
Brugia malayi jmjC domain containing protein 0.0042 0.012 0.0789
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0031 0.026
Echinococcus multilocularis Tubulin alpha 1 chain 0.0033 0.0087 0.0087
Loa Loa (eye worm) tubulin beta chain 0.0011 0.0001 0.0007
Mycobacterium tuberculosis Conserved protein 0.0038 0.0106 0.1177
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0125 0.0392
Schistosoma mansoni dihydropteridine reductase 0.0013 0.0009 0.0027
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0031 0.0098
Brugia malayi jmjC domain containing protein 0.0103 0.0358 0.236
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0031 0.026
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0031 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0004 0.0257
Brugia malayi Raf kinase 0.0216 0.0791 0.5207
Brugia malayi Tubulin gamma chain 0.0025 0.0055 0.0361
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0 0.0001
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0522 0.1665
Trypanosoma cruzi tubulin gamma chain 0.0025 0.0055 0.0469
Echinococcus multilocularis cyclins 0.0018 0.003 0.003
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.029 0.3233
Brugia malayi Tubulin beta chain 0.0011 0.0001 0.0007
Brugia malayi Cyclin, N-terminal domain containing protein 0.0044 0.0128 0.0844
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0009 0.0128
Echinococcus multilocularis tubulin alpha 0.0025 0.0055 0.0055
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0032 0.0083 0.026
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0132 0.0871
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0009 0.0128
Loa Loa (eye worm) hypothetical protein 0.0044 0.0128 0.0844
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0056 0.0481
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0327 0.3645
Trypanosoma brucei beta tubulin 0.0025 0.0055 0.0469
Schistosoma mansoni tubulin subunit beta 0.0025 0.0055 0.0175
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0082 0.026
Echinococcus granulosus Dipeptidyl peptidase 9 0.0136 0.0484 0.1545
Trypanosoma brucei prolyl oligopeptidase, putative 0.0032 0.0083 0.0719
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0009 0.0128
Giardia lamblia Alpha-tubulin 0.0033 0.0087 0.6577
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.001 0.0706
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0125 0.9451
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.001 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0079
Leishmania major beta tubulin 0.0025 0.0055 0.0469
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0024 0.0156
Trichomonas vaginalis tubulin, putative 0.0014 0.0014 0.0952
Trypanosoma cruzi CYC2-like cyclin, putative 0.0044 0.0128 0.1111
Onchocerca volvulus 0.0021 0.0042 0.0275
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0009 0.0084
Schistosoma mansoni Smad4 0.0017 0.0024 0.0076
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0025 0.0056 0.0943
Loa Loa (eye worm) cytochrome P450 family protein 0.0102 0.0353 0.2322
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0025 0.0056 0.0481
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0317 0.1013
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0054 0.0173
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.001 0.0079
Giardia lamblia Alanyl dipeptidyl peptidase 0.0032 0.0083 0.6276
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0025 0.0056 0.0481
Schistosoma mansoni smad1 5 8 and 0.0017 0.0024 0.0076
Mycobacterium tuberculosis Probable peptidase 0.0032 0.0083 0.092
Echinococcus granulosus Smad4 0.0017 0.0024 0.0076
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.001 0.0706
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0025 0.0056 0.0615
Trypanosoma cruzi cdc2-related kinase 3 0.0045 0.0132 0.1146
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0031 0.0261
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0145 0.0145
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0025 0.0056 0.0943
Brugia malayi prolyl oligopeptidase family protein 0.0032 0.0083 0.0549
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0105 0.0906
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0106 0.8028
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.0132 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Leishmania major alpha tubulin 0.0033 0.0087 0.0754
Trichomonas vaginalis tubulin beta chain, putative 0.0025 0.0055 0.4094
Schistosoma mansoni hypothetical protein 0.034 0.1269 0.4051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0317 0.1013
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0032 0.0083 0.0266
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.001 0.0018
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0163 0.1415
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0106 0.034
Toxoplasma gondii ABC1 family protein 0.0038 0.0106 0.0333
Mycobacterium ulcerans hypothetical protein 0.0162 0.0585 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0057 0.0491
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.003 0.0097
Mycobacterium leprae Conserved hypothetical protein 0.0025 0.0056 0.1687
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.001 0.0079
Onchocerca volvulus 0.0058 0.0183 0.1203
Loa Loa (eye worm) tubulin alpha chain 0.0033 0.0087 0.0575
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0237 0.0873 0.0873
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.001 0.0108
Echinococcus multilocularis tubulin alpha chain 0.0033 0.0087 0.0087
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0015 0.0049
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.012 0.0383
Toxoplasma gondii exonuclease III APE 0.0018 0.003 0.0092
Toxoplasma gondii alpha-tubulin I, putative 0.0033 0.0087 0.0273
Schistosoma mansoni hypothetical protein 0.0048 0.0145 0.0462
Leishmania major alpha tubulin 0.0033 0.0087 0.0754
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0054 0.0054
Echinococcus multilocularis tubulin subunit TubB 0.0033 0.0087 0.0087
Mycobacterium leprae putative cytochrome p450 0.0025 0.0056 0.1687
Schistosoma mansoni cytochrome P450 0.0025 0.0056 0.0179
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0009 0.0128
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0083 0.0719
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0009 0.0084
Schistosoma mansoni tubulin subunit alpha 0.0033 0.0087 0.0279
Brugia malayi tubulin alpha chain - mouse 0.0033 0.0087 0.0575
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0025 0.0056 0.0943
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0015 0.0015
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0031 0.0203
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.0432 0.138
Trypanosoma cruzi cdc2-related kinase 1 0.0045 0.0132 0.1146
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0132 1
Echinococcus granulosus tubulin alpha chain 0.0033 0.0087 0.0279
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0045 0.0132 0.0415
Brugia malayi Tubulin beta-1 chain 0.0025 0.0055 0.0361
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0001
Mycobacterium tuberculosis Possible oxidoreductase 0.0013 0.0009 0.0084
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0032 0.0083 0.6276
Brugia malayi Tubulin alpha-2 chain 0.0033 0.0087 0.0575
Trypanosoma brucei tubulin gamma chain 0.0025 0.0055 0.0469
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0044 0.0129 0.0847
Trichomonas vaginalis tubulin gamma chain, putative 0.0025 0.0055 0.4094
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0009 0.0128
Loa Loa (eye worm) hypothetical protein 0.0032 0.0083 0.0549
Echinococcus granulosus N chimaerin 0.0012 0.0005 0.0015
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0106 0.1177
Trichomonas vaginalis cyclin B, putative 0.0044 0.0128 0.9689
Schistosoma mansoni ap endonuclease 0.0018 0.003 0.0097
Leishmania major beta tubulin 0.0025 0.0055 0.0469
Leishmania major beta tubulin 0.0025 0.0055 0.0469
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0015 0.0049
Echinococcus granulosus tubulin alpha chain 0.0033 0.0087 0.0279
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0031 0.0076
Schistosoma mansoni hypothetical protein 0.0048 0.0145 0.0462
Schistosoma mansoni cyclin B3 0.0018 0.003 0.0096
Giardia lamblia Gamma tubulin 0.0025 0.0055 0.4094
Schistosoma mansoni hypothetical protein 0.0048 0.0145 0.0462
Trichomonas vaginalis esterase, putative 0.0038 0.0106 0.8028
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.001 0.0108
Echinococcus multilocularis N chimaerin 0.0012 0.0005 0.0005
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0183 0.1203
Brugia malayi Cell division protein ftsZ 0.0011 0.0001 0.0007
Treponema pallidum NADH oxidase 0.0013 0.001 0.3085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0079
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0022 0.0046 0.0304
Echinococcus multilocularis cyclin B3 1 0.0018 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Schistosoma mansoni tubulin subunit beta 0.0025 0.0055 0.0175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0009 0.0128
Leishmania major trypanothione reductase 0.0038 0.0105 0.0906
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0032 0.0083 0.0719
Loa Loa (eye worm) CYP4Cod1 0.0034 0.009 0.0594
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0021 0.0042 0.1249
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0106 0.092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0522 0.3435
Leishmania major beta tubulin 0.0025 0.0055 0.0469
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Plasmodium falciparum glutathione reductase 0.0038 0.0105 0.1243
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0031 0.026
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0106 0.1177
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.0087 0.6577
Loa Loa (eye worm) hypothetical protein 0.0032 0.0083 0.0549
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0021 0.0042 0.0698
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.003 0.035
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.003 0.0255
Entamoeba histolytica cyclin, putative 0.0044 0.0128 0.9601
Toxoplasma gondii thioredoxin reductase 0.0038 0.0105 0.0328
Giardia lamblia Beta tubulin 0.0025 0.0055 0.4094
Trypanosoma brucei alpha tubulin 0.0033 0.0087 0.0754
Echinococcus granulosus tyrosine protein kinase Lyn 0.0011 0.0001 0.0004
Echinococcus granulosus Tubulin beta 2C chain 0.0025 0.0055 0.0175
Trichomonas vaginalis tubulin alpha chain, putative 0.0025 0.0055 0.4094
Leishmania major beta tubulin 0.0025 0.0055 0.0469
Echinococcus granulosus tubulin beta 4A class IVa 0.0025 0.0055 0.0175
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0029 0.019
Echinococcus granulosus raf serine:threonine protein kinase 0.0223 0.0821 0.262
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0082 0.026
Giardia lamblia Cyclin A 0.0018 0.003 0.2207
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0706
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0031 0.0203
Leishmania major cytochrome p450-like protein 0.0025 0.0056 0.0481
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.001 0.0686
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0083 0.6276
Leishmania major alpha tubulin 0.0033 0.0087 0.0754
Echinococcus granulosus tubulin alpha 0.0025 0.0055 0.0175
Loa Loa (eye worm) tubulin alpha 2 0.0022 0.0046 0.0304
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0045 0.0132 0.0422
Schistosoma mansoni smad1 5 8 and 0.0017 0.0024 0.0076
Toxoplasma gondii prolyl endopeptidase 0.0032 0.0083 0.026
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0009 0.0128
Echinococcus granulosus tubulin subunit TubB 0.0033 0.0087 0.0279
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.001 0.0079
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.0087 0.6577
Toxoplasma gondii beta tubulin 0.0025 0.0055 0.017
Loa Loa (eye worm) tubulin beta-1 chain 0.0025 0.0055 0.0361
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0021 0.0042 0.0488
Plasmodium vivax tubulin alpha chain, putative 0.0033 0.0087 0.1034
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0025 0.0056 0.0943
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0308 0.1146 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0057 0.0183
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0045 0.0132 0.1146
Loa Loa (eye worm) BEN-1 protein 0.0025 0.0055 0.0361
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.001 0.0154
Brugia malayi Cyclin, N-terminal domain containing protein 0.0044 0.0128 0.0844
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0024 0.0024
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0022 0.0046 0.3435
Plasmodium vivax tubulin epsilon chain, putative 0.0025 0.0055 0.0644
Trypanosoma brucei mitotic cyclin 6 0.0044 0.0128 0.1111
Schistosoma mansoni alpha tubulin 0.0033 0.0087 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0009 0.0128
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0106 0.1805
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0025 0.0055 0.0176
Echinococcus multilocularis 0.0025 0.0056 0.0056
Leishmania major gamma-tubulin 0.0025 0.0055 0.0469
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0106 0.3229
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0018 0.003 0.003
Brugia malayi Protein kinase domain containing protein 0.0045 0.0132 0.0871
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0031 0.0098
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0025 0.0056 0.0943
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0013 0.0009 0.0065
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0031 0.0076
Leishmania major pteridine reductase 1 0.0013 0.0009 0.0065
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0031 0.026
Echinococcus multilocularis tubulin alpha 1C chain 0.0033 0.0087 0.0087
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0033 0.0087 0.6577
Echinococcus multilocularis Tubulin beta 2C chain 0.0025 0.0055 0.0055
Brugia malayi alpha-tubulin 0.0033 0.0087 0.0575
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0025 0.0056 0.0943
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0025 0.0056 0.0615
Plasmodium falciparum tubulin beta chain 0.0025 0.0055 0.0644
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0018 0.003 0.0096
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0079
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0025 0.0056 0.0943
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0031 0.026
Schistosoma mansoni alpha tubulin 0.0033 0.0087 0.0279
Loa Loa (eye worm) hypothetical protein 0.0038 0.0106 0.0701
Brugia malayi beta-lactamase 0.0038 0.0106 0.0701
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0025 0.0056 0.0943
Echinococcus multilocularis hypothetical protein 0.0033 0.0087 0.0087
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0032 0.0083 0.1411
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0025 0.0056 0.0943
Brugia malayi RhoGAP domain containing protein 0.0012 0.0005 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0288
Echinococcus granulosus Tubulin beta 2C chain 0.0025 0.0055 0.0175
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0025 0.0056 0.0943
Echinococcus multilocularis tubulin alpha 3 chain 0.0033 0.0087 0.0087
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.029 0.3233
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0082 0.0254
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0009 0.0084
Giardia lamblia Beta tubulin 0.0025 0.0055 0.4094
Plasmodium falciparum tubulin epsilon chain, putative 0.0025 0.0055 0.0644
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Echinococcus granulosus tubulin alpha 1C chain 0.0033 0.0087 0.0279
Loa Loa (eye worm) hypothetical protein 0.0032 0.0083 0.0549
Echinococcus multilocularis Tubulin alpha 1 chain 0.0033 0.0087 0.0087
Loa Loa (eye worm) tubulin alpha chain 0.0033 0.0087 0.0575
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0106 0.0701
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.029 0.8869
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0025 0.0056 0.0615
Loa Loa (eye worm) hypothetical protein 0.0152 0.0545 0.3585
Echinococcus multilocularis Tubulin beta 2C chain 0.0025 0.0055 0.0055
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0025 0.0056 0.0615
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.003 0.2223
Trichomonas vaginalis cyclin B, putative 0.0044 0.0128 0.9689
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0025 0.0056 0.0615
Trypanosoma cruzi cdc2-related kinase 3 0.0045 0.0132 0.1146
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.017 0.148
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0021 0.0042 0.0698
Loa Loa (eye worm) tubulin gamma chain 0.0025 0.0055 0.0361
Trichomonas vaginalis cyclin B3, putative 0.0018 0.003 0.2207
Loa Loa (eye worm) tubulin alpha-3 chain 0.0019 0.0034 0.0222
Schistosoma mansoni cpg binding protein 0.0061 0.0195 0.0624
Trypanosoma brucei cytochrome P450, putative 0.0034 0.009 0.0778
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0057 0.4286
Schistosoma mansoni hypothetical protein 0.0032 0.0082 0.026
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0009 0.0128
Trypanosoma cruzi beta tubulin, putative 0.0025 0.0055 0.0469
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0031 0.0094
Leishmania major beta tubulin 0.0025 0.0055 0.0469
Leishmania major alpha tubulin 0.0033 0.0087 0.0754
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.003 0.2207
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0001
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0132 0.0132
Echinococcus granulosus smad 0.0017 0.0024 0.0076
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.001 0.0686
Trichomonas vaginalis cyclin D, putative 0.0018 0.003 0.2207
Echinococcus granulosus Tubulin beta 2C chain 0.0025 0.0055 0.0175
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0032 0.0083 0.0719
Echinococcus multilocularis tubulin alpha chain 0.0033 0.0087 0.0087
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0021 0.0042 0.0356
Trypanosoma cruzi epsilon tubulin, putative 0.0025 0.0055 0.0469
Plasmodium falciparum thioredoxin reductase 0.0038 0.0105 0.1243
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0106 0.092
Trichomonas vaginalis cyclins, putative 0.0044 0.0128 0.9689
Echinococcus granulosus cyclin dependent kinase 5 0.0045 0.0132 0.0422
Echinococcus multilocularis tubulin epsilon chain 0.0025 0.0055 0.0055
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0025 0.0056 0.0943
Brugia malayi PHD-finger family protein 0.0014 0.0012 0.0081
Entamoeba histolytica prolyl oligopeptidase family protein 0.0032 0.0083 0.5221
Echinococcus multilocularis dnaJ subfamily B 0.0824 0.3133 0.3133
Trichomonas vaginalis tubulin, putative 0.0014 0.0014 0.0952
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.0012 0.0012
Brugia malayi PHD-finger family protein 0.0032 0.0082 0.0537
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0031 0.0098
Plasmodium falciparum cyclin 0.0018 0.003 0.0347
Loa Loa (eye worm) Smad1 0.0017 0.0024 0.0156
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.029 0.3233
Schistosoma mansoni serine/threonine protein kinase 0.0237 0.0873 0.2787
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.0545 0.3585
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0025 0.0056 0.0943
Brugia malayi Cytochrome P450 family protein 0.0034 0.009 0.0594
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0537
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0211 0.139
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0024 0.0076
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0021 0.0042 0.0356
Brugia malayi MH2 domain containing protein 0.0017 0.0024 0.0156
Brugia malayi transcription factor E74 isoform 0.001 0 0.0001
Echinococcus granulosus cyclins 0.0018 0.003 0.0096
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0009 0.0128
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0031 0.026
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0025 0.0056 0.0615
Schistosoma mansoni cpg binding protein 0.0058 0.0183 0.0583
Brugia malayi hypothetical protein 0.0035 0.0096 0.0631
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0106 0.0701
Trypanosoma cruzi cdc2-related kinase 1 0.0045 0.0132 0.1146
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0025 0.0056 0.0943
Trichomonas vaginalis tubulin alpha chain, putative 0.0025 0.0055 0.4094
Loa Loa (eye worm) raf kinase 0.0221 0.0812 0.5348
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0031 0.026
Trypanosoma brucei beta tubulin 0.0025 0.0055 0.0469
Loa Loa (eye worm) hypothetical protein 0.0038 0.0106 0.0701
Plasmodium vivax tubulin gamma chain, putative 0.0025 0.0055 0.0644
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0013 0.0009 0.0128
Echinococcus granulosus tubulin alpha chain 0.0033 0.0087 0.0279
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0106 0.0106
Trichomonas vaginalis tubulin alpha chain, putative 0.0014 0.0014 0.0952
Entamoeba histolytica hypothetical protein 0.0025 0.0057 0.2668
Trichomonas vaginalis hypothetical protein 0.0013 0.0009 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Trypanosoma cruzi cyclin, putative 0.0044 0.0128 0.1111
Mycobacterium leprae Probable lipase LipE 0.0038 0.0106 0.3229
Trichomonas vaginalis cyclin B, putative 0.0018 0.003 0.2207
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.001 0.0108
Echinococcus multilocularis cyclin dependent kinase 0.0045 0.0132 0.0132
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.001 0.0706
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0706
Brugia malayi MH2 domain containing protein 0.0243 0.0897 0.5906
Schistosoma mansoni tubulin subunit beta 0.0025 0.0055 0.0175
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0106 0.8028
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0706
Echinococcus granulosus tubulin gamma 1 chain 0.0025 0.0055 0.0175
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0013 0.0009 0.0024
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0106 0.1177
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.001 0.0101
Echinococcus multilocularis tubulin alpha chain 0.0033 0.0087 0.0087
Echinococcus multilocularis cpg binding protein 0.0061 0.0195 0.0195
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0129 0.0413
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0013 0.0009 0.009
Schistosoma mansoni cpg binding protein 0.0061 0.0195 0.0624
Echinococcus granulosus tubulin delta chain 0.0011 0.0001 0.0003
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.001 0.0706
Brugia malayi beta-lactamase family protein 0.0038 0.0106 0.0701
Leishmania major alpha tubulin 0.0033 0.0087 0.0754
Leishmania major beta tubulin 0.0025 0.0055 0.0469
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.009 0.0594
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0127 0.1097
Loa Loa (eye worm) prolyl oligopeptidase 0.0032 0.0083 0.0549
Trypanosoma brucei beta tubulin 0.0025 0.0055 0.0469
Loa Loa (eye worm) hypothetical protein 0.0038 0.0106 0.0701
Echinococcus multilocularis Tubulin alpha 1 chain 0.0033 0.0087 0.0087
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0106 0.034
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0127 0.045 0.2961
Brugia malayi Smad1 0.0017 0.0024 0.0156
Echinococcus granulosus beta tubulin 0.0025 0.0055 0.0175
Brugia malayi prolyl oligopeptidase family protein 0.0032 0.0083 0.0549
Loa Loa (eye worm) glutathione reductase 0.0038 0.0105 0.069
Echinococcus granulosus cyclin b3 0.0018 0.003 0.0096
Echinococcus granulosus cyclins 0.0018 0.003 0.0096
Leishmania major oxidoreductase-like protein 0.0013 0.0009 0.0065
Brugia malayi Variant SH3 domain containing protein 0.0012 0.0005 0.003
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0522 0.0522
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0029 0.0029
Echinococcus multilocularis tubulin alpha 3 chain 0.0033 0.0087 0.0087
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0068 0.0446
Wolbachia endosymbiont of Brugia malayi (3R)-hydroxymyristoyl-ACP dehydratase 0.0227 0.0836 1
Echinococcus granulosus tubulin subunit beta 0.0025 0.0055 0.0175
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0132 0.0422
Schistosoma mansoni hypothetical protein 0.0025 0.0056 0.0179
Toxoplasma gondii hypothetical protein 0.0032 0.0083 0.026
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0031 0.026
Leishmania major beta tubulin 0.0025 0.0055 0.0469
Brugia malayi prolyl oligopeptidase family protein 0.0032 0.0083 0.0549
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.0087 0.6577
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0025 0.0056 0.0943
Echinococcus multilocularis tubulin gamma 1 chain 0.0025 0.0055 0.0055
Brugia malayi tubulin alpha-2 chain 0.0033 0.0087 0.0575
Brugia malayi prolyl oligopeptidase family protein 0.0405 0.1519 1
Echinococcus multilocularis peregrin 0.0035 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0033 0.0087 0.0575
Echinococcus granulosus tubulin epsilon chain 0.0025 0.0055 0.0175
Loa Loa (eye worm) tubulin alpha 2 0.0022 0.0046 0.0304
Brugia malayi Cytochrome P450 family protein 0.0102 0.0353 0.2322
Trypanosoma cruzi oligopeptidase b 0.0032 0.0083 0.0719
Echinococcus multilocularis Tubulin beta 2C chain 0.0025 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0056
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0044 0.0372
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.0087 0.6577
Leishmania major hypothetical protein, conserved 0.0055 0.017 0.148
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0013 0.0146
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.009 0.0594
Echinococcus granulosus tubulin alpha 1C chain 0.0033 0.0087 0.0279
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0136 0.0484 0.4219
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0132 0.0132
Brugia malayi MH1 domain containing protein 0.0017 0.0024 0.0156
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0021 0.0042 0.0356
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0145 0.0462
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0024 0.0024
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0405 0.1519 0.4848
Mycobacterium ulcerans lipase LipD 0.0038 0.0106 0.1805
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0025 0.0056 0.0943
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.001 0.0706
Loa Loa (eye worm) oxidoreductase 0.0021 0.0042 0.0275
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0031 0.026
Echinococcus multilocularis Tubulin beta 2C chain 0.0025 0.0055 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0032 0.0083 0.0266
Loa Loa (eye worm) prolyl oligopeptidase 0.0405 0.1519 1
Plasmodium falciparum protein kinase 5 0.0045 0.0132 0.1572
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0706
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0025 0.0056 0.0615
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0012 0.0005 0.0015
Plasmodium vivax tubulin alpha chain, putative 0.0033 0.0087 0.1034
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.0087 0.6577
Leishmania major beta tubulin 0.0025 0.0055 0.0469
Entamoeba histolytica tubulin alpha-1 chain 0.0033 0.0087 0.5607
Brugia malayi glutathione reductase 0.0038 0.0105 0.069
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.003 0.035
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0107 0.0107
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0129 0.0129
Loa Loa (eye worm) alpha-tubulin 0.0033 0.0087 0.0575
Plasmodium vivax protein kinase Crk2 0.0045 0.0132 0.1572
Giardia lamblia G2/mitotic-specific cyclin B 0.0044 0.0128 0.9689
Schistosoma mansoni vav2 0.0012 0.0005 0.0015
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0021 0.0042 0.0455
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0111 0.1321
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0106 0.034
Toxoplasma gondii beta-1 tubulin, putative 0.0025 0.0055 0.017
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0105 0.1159
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.001 0.0706
Mycobacterium tuberculosis Probable reductase 0.0086 0.029 0.3233
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0045 0.0132 0.1146
Plasmodium falciparum tubulin gamma chain 0.0025 0.0055 0.0644
Echinococcus multilocularis raf serine:threonine protein kinase 0.0223 0.0821 0.0821
Echinococcus granulosus geminin 0.034 0.1269 0.4051
Loa Loa (eye worm) hypothetical protein 0.0025 0.0058 0.0382
Loa Loa (eye worm) hypothetical protein 0.0062 0.0197 0.1297
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0032 0.0083 0.092
Echinococcus granulosus tubulin beta 1 chain 0.0025 0.0055 0.0175
Trypanosoma brucei alpha tubulin, putative 0.0014 0.0014 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0706
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0106 0.1177
Brugia malayi DNA-binding protein D-ETS-3 0.001 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Brugia malayi Tubulin alpha chain 0.0033 0.0087 0.0575
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0021 0.0042 0.0134
Trypanosoma brucei oligopeptidase b 0.0032 0.0083 0.0719
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.012 0.0383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0145 0.0954
Loa Loa (eye worm) hypothetical protein 0.0054 0.0169 0.111
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.012 0.0789
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0106 0.1177
Echinococcus multilocularis tubulin alpha chain 0.0033 0.0087 0.0087
Schistosoma mansoni tubulin subunit beta 0.0025 0.0055 0.0175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.2266
Schistosoma mansoni tubulin subunit beta 0.0025 0.0055 0.0175
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0012 0.0004 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0106 0.092
Schistosoma mansoni tubulin subunit delta 0.0011 0.0001 0.0003
Leishmania major alpha tubulin 0.0033 0.0087 0.0754
Trypanosoma brucei beta tubulin 0.0025 0.0055 0.0469
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.036 0.2367
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.009 0.0778
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.001 0.0706
Leishmania major beta tubulin 0.0025 0.0055 0.0469
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0032 0.0083 0.0719
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.017 0.148
Brugia malayi MH2 domain containing protein 0.0017 0.0024 0.0156
Echinococcus multilocularis smad 0.0017 0.0024 0.0024
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0025 0.0055 0.017
Brugia malayi prolyl oligopeptidase family protein 0.0136 0.0484 0.3187
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0237 0.0757
Echinococcus multilocularis cyclins 0.0018 0.003 0.003
Brugia malayi hypothetical protein 0.0104 0.036 0.2373
Echinococcus multilocularis cyclins 0.0018 0.003 0.003
Echinococcus granulosus cytochrome P450 2K1 0.0025 0.0056 0.0179
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.0545 0.3585
Schistosoma mansoni jumonji domain containing protein 0.0082 0.0277 0.0883
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.001 0.0079
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0044 0.0128 0.0844
Loa Loa (eye worm) fli-1 protein 0.0219 0.0802 0.5281
Schistosoma mansoni smad 0.0017 0.0024 0.0076
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.003 0.2223
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0056 0.0481
Onchocerca volvulus 0.0014 0.0014 0.0089
Echinococcus multilocularis cyclins 0.0018 0.003 0.003
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0021 0.0042 0.0356
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0025 0.0056 0.0481
Toxoplasma gondii hypothetical protein 0.005 0.0151 0.0474
Trypanosoma brucei cdc2-related kinase 3 0.0045 0.0132 0.1146
Echinococcus multilocularis tubulin subunit beta 0.0025 0.0055 0.0055
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.0897 0.5906
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0029 0.0092
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0021 0.0042 0.0488
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.001 0.0028
Toxoplasma gondii hypothetical protein 0.0014 0.0013 0.0038
Schistosoma mansoni smad1 5 8 and 0.0017 0.0024 0.0076
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0013 0.0009 0.0024
Trypanosoma brucei trypanothione reductase 0.0038 0.0105 0.0906
Plasmodium falciparum beta-hydroxyacyl-ACP dehydratase 0.0227 0.0836 1
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0013 0.0009 0.0065
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0013 0.0009 0.009
Trichomonas vaginalis tubulin epsilon chain, putative 0.0025 0.0055 0.4094
Loa Loa (eye worm) tubulin alpha-2 chain 0.0033 0.0087 0.0575
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0025 0.0056 0.0943
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0021 0.0042 0.0698
Onchocerca volvulus 0.0038 0.0106 0.0701
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0021 0.0042 0.0134
Leishmania major oligopeptidase b 0.0032 0.0083 0.0719
Trypanosoma brucei cdc2-related kinase 1 0.0045 0.0132 0.1146
Loa Loa (eye worm) retinol dehydrogenase 12 0.0013 0.0009 0.0056
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0079
Echinococcus granulosus cyclin B3 1 0.0018 0.003 0.0096
Echinococcus granulosus beta tubulin 0.0025 0.0055 0.0175
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.001 0.0686
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0111 0.795
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0013 0.0009 0.0229
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.0832 0.3165 1
Leishmania major beta tubulin 0.0025 0.0055 0.0469
Brugia malayi Cytochrome P450 family protein 0.0034 0.009 0.0594
Echinococcus granulosus Tubulin beta 2C chain 0.0025 0.0055 0.0175
Schistosoma mansoni tubulin subunit alpha 0.0033 0.0087 0.0279
Schistosoma mansoni hypothetical protein 0.0824 0.3133 1
Echinococcus granulosus tubulin alpha 3 chain 0.0033 0.0087 0.0279
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.001 0.0079
Schistosoma mansoni hypothetical protein 0.0048 0.0145 0.0462
Echinococcus multilocularis cyclins 0.0018 0.003 0.003
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0105 0.069
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0021 0.0042 0.0698
Trypanosoma brucei prolyl endopeptidase 0.0032 0.0083 0.0719
Trichomonas vaginalis tubulin epsilon chain, putative 0.0025 0.0055 0.4094
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0013 0.0009 0.0084
Plasmodium vivax glutathione reductase, putative 0.0038 0.0105 0.1243
Echinococcus granulosus cyclin dependent kinase 1 0.0045 0.0132 0.0422

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 1 mM Inhibition of human promyelocyticleukemic cell (HL-60) by XXT-microculture tetrazolium assay ChEMBL. 2033590
IC50 (functional) > 1 mM Inhibition of human promyelocyticleukemic cell (HL-60) trypan blue exclusion assay ChEMBL. 2033590
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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