Detailed information for compound 1851944

Basic information

Technical information
  • TDR Targets ID: 1851944
  • Name: [(2R,3S,4R,5R)-5-(4-carbamoyl-1,3-thiazol-2-y l)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
  • MW: 340.247 | Formula: C9H13N2O8PS
  • H donors: 5 H acceptors: 7 LogP: -3.29 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]1[C@H](O)[C@H](O[C@H]1c1scc(n1)C(=O)N)COP(=O)(O)O
  • InChi: 1S/C9H13N2O8PS/c10-8(14)3-2-21-9(11-3)7-6(13)5(12)4(19-7)1-18-20(15,16)17/h2,4-7,12-13H,1H2,(H2,10,14)(H2,15,16,17)/t4-,5-,6-,7-/m1/s1
  • InChiKey: XDDGVTBJYGSVPM-DBRKOABJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2R,3S,4R,5R)-5-(4-carbamoylthiazol-2-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate
  • [(2R,3S,4R,5R)-5-(4-carbamoyl-2-thiazolyl)-3,4-dihydroxy-2-tetrahydrofuranyl]methyl dihydrogen phosphate
  • [(2R,3S,4R,5R)-5-(4-aminocarbonyl-1,3-thiazol-2-yl)-3,4-dihydroxy-oxolan-2-yl]methyl dihydrogen phosphate
  • 4-Thiazolecarboxamide der.
  • AIDS-014566
  • AIDS014566
  • Phosphoric acid mono-[5-(4-carbamoyl-thiazol-2-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0007 0.007
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0105 0.4204
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0003 0.0003
Schistosoma mansoni vesicular amine transporter 0.0383 0.0895 0.1018
Brugia malayi hypothetical protein 0.0132 0.0284 0.0284
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0004 0.0029
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.013
Echinococcus granulosus peptide allatostatin:somatostatin 0.0132 0.0284 0.0324
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.003 0.003
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0132 0.0284 0.0284
Brugia malayi hypothetical protein 0.0474 0.1117 0.1117
Schistosoma mansoni hypothetical protein 0.1035 0.2481 0.2822
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0165 0.0364 1
Leishmania major trypanothione reductase 0.0049 0.0082 0.0081
Brugia malayi Pre-SET motif family protein 0.0216 0.0488 0.0488
Brugia malayi larval opioid receptor 0.0132 0.0284 0.0284
Schistosoma mansoni hypothetical protein 0.0049 0.0081 0.0093
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0011 0.0008
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.003 0.003
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0052 0.009 0.0102
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0079 0.0154 0.0175
Onchocerca volvulus 0.0016 0.0001 0.0001
Loa Loa (eye worm) glutamate receptor 2 0.0152 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.009
Brugia malayi Abnormal catecholamine distribution protein 1 0.0383 0.0895 0.0895
Brugia malayi RE15519p 0.0132 0.0284 0.0284
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0003 0.0003
Schistosoma mansoni inositol monophosphatase 0.0111 0.0232 0.0264
Loa Loa (eye worm) neuropeptide F receptor 0.0132 0.0284 0.0284
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0099 0.0204 0.7343
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0011 0.0271
Echinococcus granulosus glycine receptor subunit alpha 1 0.0052 0.009 0.0102
Schistosoma mansoni glutamate receptor NMDA 0.0248 0.0567 0.0645
Echinococcus multilocularis dna polymerase eta 0.002 0.0011 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.003 0.0035 0.0603
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0004 0.0005
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0016 0.0001 0.0001
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0051 0.0051
Schistosoma mansoni glutamate receptor kainate 0.0152 0.0331 0.0377
Leishmania major carbonic anhydrase-like protein 0.0568 0.1345 0.1344
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0132 0.0284 0.0324
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0082 0.0082
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0165 0.0364 0.0414
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0003
Brugia malayi hypothetical protein 0.0024 0.0021 0.0021
Echinococcus multilocularis g protein coupled receptor 0.0132 0.0284 0.0324
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0003 0.0003
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0011 0.04
Echinococcus granulosus nmda type glutamate receptor 0.0137 0.0297 0.0337
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0018 0.0007 0.0008
Echinococcus multilocularis sex peptide receptor 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.013
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0054 0.0062
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0568 0.1345 0.1345
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.0284 0.0324
Brugia malayi hypothetical protein 0.0027 0.0028 0.0028
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0051 0.0917
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Echinococcus granulosus neuropeptide FF receptor 2 0.0132 0.0284 0.0324
Brugia malayi Animal haem peroxidase family protein 0.0069 0.013 0.013
Onchocerca volvulus 0.0038 0.0054 0.0062
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0081 0.0081
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0057 0.0057
Schistosoma mansoni nAChR subunit 0.0024 0.0021 0.0024
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.0235 0.4423
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0121 0.0121
Onchocerca volvulus 0.0028 0.0031 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.003 0.0035 0.0603
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0056 0.0099 0.0113
Echinococcus multilocularis allatostatin A receptor 0.0132 0.0284 0.0324
Echinococcus granulosus glycine receptor subunit alpha 1 0.0052 0.009 0.0102
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0251 0.0574 0.0574
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0051 0.0058
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0024 0.0021 0.0021
Echinococcus multilocularis lamin b receptor 0.0098 0.0202 0.0229
Loa Loa (eye worm) norepinephrine transporter 0.0971 0.2325 0.2325
Brugia malayi hypothetical protein 0.0171 0.0378 0.0378
Echinococcus multilocularis g-protein coupled receptor 0.0132 0.0284 0.0324
Leishmania major protein kinase, putative 0.0018 0.0007 0.0006
Schistosoma mansoni glutamate receptor NMDA 0.0322 0.0746 0.0848
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0051 0.0087 0.0087
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0000000053194 0.0000000060508
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0052 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0062 0.007
Echinococcus multilocularis lamin dm0 0.0028 0.003 0.0034
Schistosoma mansoni ap endonuclease 0.0059 0.0105 0.012
Loa Loa (eye worm) hypothetical protein 0.0028 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Onchocerca volvulus 0.0246 0.0561 0.0638
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0132 0.0284 0.0324
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0165 0.0364 0.0414
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.003 0.0035 0.1271
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.003 0.0035 0.0603
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0004 0.0018
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0056 0.0099 0.0113
Loa Loa (eye worm) glutamate receptor 1 0.0152 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Loa Loa (eye worm) animal heme peroxidase 0.0069 0.013 0.013
Brugia malayi Blistered cuticle protein 3 0.0069 0.013 0.013
Entamoeba histolytica recQ family helicase, putative 0.0024 0.002 0.0789
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0251 0.0574 0.0574
Schistosoma mansoni hypothetical protein 0.0049 0.0081 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0008
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0126 0.0269 0.0306
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0134 0.5459
Onchocerca volvulus Peroxidase homolog 0.0069 0.013 0.0148
Echinococcus multilocularis neuropeptide receptor A26 0.0132 0.0284 0.0324
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0021 0.0021
Onchocerca volvulus 0.0126 0.027 0.0307
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0132 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.009
Onchocerca volvulus 0.0052 0.009 0.0102
Brugia malayi beta-lactamase 0.0036 0.0051 0.0051
Mycobacterium ulcerans lipase LipD 0.0036 0.0051 0.1955
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0052 0.009 0.0102
Schistosoma mansoni neuropeptide F-like receptor 0.0132 0.0284 0.0324
Brugia malayi hypothetical protein 0.0132 0.0284 0.0284
Brugia malayi metabotropic glutamate receptor type 2 0.0016 0.0001 0.0001
Onchocerca volvulus 0.0031 0.0038 0.0043
Loa Loa (eye worm) TYRA-2 protein 0.0132 0.0284 0.0284
Schistosoma mansoni sodium/chloride dependent transporter 0.0165 0.0364 0.0414
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.003 0.0035 0.1271
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.013
Echinococcus multilocularis fmrfamide receptor 0.0132 0.0284 0.0324
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0165 0.0364 0.0414
Schistosoma mansoni neurotransmitter gated ion channel 0.0028 0.0031 0.0035
Loa Loa (eye worm) ACC-1 protein 0.0052 0.009 0.009
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.4127 1 1
Echinococcus multilocularis glutamate receptor 2 0.0152 0.0331 0.0377
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0003 0.0003
Schistosoma mansoni Lamin B receptor (ERG24) 0.0098 0.0202 0.0229
Schistosoma mansoni nAChR subunit 0.0052 0.009 0.0102
Loa Loa (eye worm) hypothetical protein 0.0126 0.027 0.027
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0024 0.0021 0.0024
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0132 0.0284 0.0324
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0051 0.0058
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Brugia malayi follicle stimulating hormone receptor 0.0612 0.1452 0.1452
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.003 0.0035 0.0603
Loa Loa (eye worm) hypothetical protein 0.0474 0.1117 0.1117
Echinococcus granulosus tm gpcr rhodopsin 0.2805 0.6785 0.7718
Loa Loa (eye worm) G-protein coupled receptor 0.0132 0.0284 0.0284
Schistosoma mansoni survival motor neuron protein 0.0097 0.0198 0.0225
Echinococcus multilocularis tyrosine kinase 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0154 0.0338 0.0338
Plasmodium falciparum glutathione reductase 0.0049 0.0082 0.1386
Loa Loa (eye worm) hypothetical protein 0.0971 0.2325 0.2325
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0039 0.0968
Onchocerca volvulus 0.0132 0.0284 0.0324
Leishmania major DNA polymerase kappa, putative 0.002 0.0011 0.001
Echinococcus multilocularis vesicular acetylcholine transporter 0.363 0.8791 1
Brugia malayi Dopamine receptor protein 2 0.0132 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.013
Schistosoma mansoni rab6-interacting 0.0021 0.0014 0.0016
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0011 0.0008
Trypanosoma cruzi C-14 sterol reductase, putative 0.0098 0.0202 0.0201
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0028 0.0031 0.0031
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0051 0.0917
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0007 0.0007
Onchocerca volvulus 0.0036 0.0051 0.0058
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0051 0.1334
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0105 0.0219 0.0219
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0024 0.0021 0.0024
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0016 0.0001 0.0001
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0105 0.1817
Loa Loa (eye worm) phosphofructokinase 0.0116 0.0245 0.0245
Brugia malayi putative neuropeptide receptor NPR1 0.0132 0.0284 0.0284
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0132 0.0284 0.0324
Onchocerca volvulus 0.0069 0.013 0.0148
Brugia malayi putative neuropeptide receptor 0.0132 0.0284 0.0284
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0024 0.0021 0.0024
Brugia malayi sulfakinin receptor protein 0.0132 0.0284 0.0284
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0039 0.0629
Echinococcus granulosus dro:myosuppressin receptor 0.0132 0.0284 0.0324
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0051 0.0917
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0077 0.0087
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.0284 0.0324
Brugia malayi AKH receptor 0.0132 0.0284 0.0284
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0105 0.0104
Echinococcus multilocularis neuropeptides capa receptor 0.0132 0.0284 0.0324
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.003 0.0035 0.0603
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.003 0.0035 0.0603
Brugia malayi Cation transporter family protein 0.0052 0.009 0.009
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0052 0.009 0.009
Echinococcus multilocularis nAChR subunit 0.0028 0.0031 0.0035
Echinococcus multilocularis nmda type glutamate receptor 0.0137 0.0297 0.0337
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.003 0.0035 0.1271
Schistosoma mansoni hypothetical protein 0.0132 0.0284 0.0324
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0165 0.0364 0.0414
Onchocerca volvulus 0.0028 0.0031 0.0035
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0052 0.009 0.009
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0000000053194 0.0000000060508
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0016 0.0001 0.0001
Echinococcus granulosus cytochrome P450 2K1 0.003 0.0035 0.0039
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Onchocerca volvulus 0.0132 0.0284 0.0324
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0052 0.009 0.0102
Loa Loa (eye worm) animal heme peroxidase 0.0069 0.013 0.013
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0024 0.0021 0.0021
Echinococcus granulosus glycine receptor subunit beta 0.0052 0.009 0.0102
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0052 0.009 0.0102
Echinococcus multilocularis dna polymerase kappa 0.002 0.0011 0.0012
Onchocerca volvulus 0.0132 0.0284 0.0324
Brugia malayi TAR-binding protein 0.0065 0.0121 0.0121
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.003 0.0035 0.0603
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0004 0.0003
Brugia malayi isocitrate dehydrogenase 0.0017 0.0003 0.0003
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0039 0.0625
Loa Loa (eye worm) hypothetical protein 0.0251 0.0574 0.0574
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.002 0.0019
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0028 0.0031 0.0035
Onchocerca volvulus 0.0971 0.2325 0.2644
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0038 0.0043
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.363 0.8791 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0165 0.0364 0.0414
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0134 0.0133
Onchocerca volvulus 0.0052 0.009 0.0102
Echinococcus multilocularis glutamate receptor 2 0.0111 0.0233 0.0265
Schistosoma mansoni amine GPCR 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypoxia-induced factor 1 0.0158 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0971 0.2325 0.2325
Schistosoma mansoni neuropeptide receptor 0.0468 0.1101 0.1252
Onchocerca volvulus 0.0126 0.027 0.0307
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.003 0.0035 0.0603
Mycobacterium leprae Probable lipase LipE 0.0036 0.0051 0.0714
Echinococcus granulosus lamin 0.0028 0.003 0.0034
Brugia malayi hypothetical protein 0.0024 0.0021 0.0021
Echinococcus multilocularis glycine receptor subunit beta 0.0052 0.009 0.0102
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0039 0.0625
Loa Loa (eye worm) hypothetical protein 0.0165 0.0364 0.0364
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0132 0.0284 0.0284
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.0528 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0111 0.0232 0.9494
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0077 0.0087
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.013
Onchocerca volvulus 0.0036 0.0051 0.0058
Brugia malayi Cation transporter family protein 0.0052 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0052 0.009 0.0102
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0007 0.007
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0105 0.1949
Schistosoma mansoni glutamate receptor kainate 0.0152 0.0331 0.0377
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0052 0.009 0.009
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0052 0.009 0.009
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0165 0.0364 0.0414
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0105 0.012
Echinococcus multilocularis neuropeptide receptor 0.0468 0.1101 0.1252
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0028 0.0439
Echinococcus multilocularis serotonin transporter 0.0971 0.2325 0.2644
Onchocerca volvulus 0.0028 0.003 0.0034
Loa Loa (eye worm) acetylcholine receptor protein 0.0024 0.0021 0.0021
Brugia malayi PAS domain containing protein 0.0051 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.009
Leishmania major cytochrome p450-like protein 0.003 0.0035 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.0284 0.0324
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2805 0.6785 0.7718
Plasmodium falciparum amino acid transporter, putative 0.0165 0.0364 0.632
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0099 0.0204 0.3834
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.0265 0.5003
Loa Loa (eye worm) glutathione reductase 0.0049 0.0082 0.0082
Brugia malayi hypothetical protein 0.0024 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.009
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0052 0.009 0.0102
Loa Loa (eye worm) hypothetical protein 0.0028 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0165 0.0364 0.0364
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0003
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.009
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0052 0.009 0.009
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0126 0.027 0.0307
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0077 0.0087
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0165 0.0364 0.0364
Trypanosoma brucei trypanothione reductase 0.0049 0.0082 0.0079
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.003 0.0035 0.0603
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.013
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0014 0.0016
Echinococcus multilocularis survival motor neuron protein 1 0.0474 0.1117 0.127
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0008
Brugia malayi hypoxia-induced factor 1 0.0158 0.0346 0.0346
Schistosoma mansoni sodium/chloride dependent transporter 0.0165 0.0364 0.0414
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0121 0.0138
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.0338 0.0338
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.003 0.0035 0.0603
Echinococcus granulosus carbonic anhydrase 0.0251 0.0574 0.0652
Echinococcus multilocularis peroxidasin 0.0069 0.013 0.0148
Echinococcus granulosus GPCR family 2 0.0049 0.0081 0.0093
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.0338 0.0338
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0082 0.0093
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Echinococcus granulosus nAChR subunit 0.0028 0.0031 0.0035
Brugia malayi Bloom's syndrome protein homolog 0.0044 0.007 0.007
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.003 0.0035 0.0603
Echinococcus multilocularis lamin 0.0028 0.003 0.0034
Echinococcus granulosus intermediate filament protein 0.0028 0.003 0.0034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0003
Brugia malayi Guanylyl cyclase protein 23 0.0016 0.0001 0.0001
Onchocerca volvulus 0.0132 0.0284 0.0324
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.007 0.1186
Echinococcus multilocularis G-protein coupled receptor, putative 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0034 0.0044 0.0044
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0014 0.03
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.0265 0.5003
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0165 0.0364 0.0364
Plasmodium vivax SET domain protein, putative 0.0031 0.0038 0.0972
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0052 0.009 0.009
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0039 0.0995
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0028 0.0439
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Echinococcus granulosus bloom syndrome protein 0.0044 0.007 0.008
Echinococcus granulosus synaptic vesicular amine transporter 0.0383 0.0895 0.1018
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0039 0.3441
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.009
Brugia malayi Dopamine receptor protein 1 0.0132 0.0284 0.0284
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0003 0.0003
Echinococcus multilocularis nAChR subunit 0.0052 0.009 0.0102
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0052 0.009 0.009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0003
Loa Loa (eye worm) melatonin receptor type 1A 0.0132 0.0284 0.0284
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0016 0.0001 0.0001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0132 0.0284 0.0324
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0004 0.0005
Loa Loa (eye worm) glutamate receptor 0.0016 0.0001 0.0001
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0051 0.0917
Echinococcus multilocularis glutamate receptor 2 0.0167 0.0369 0.042
Schistosoma mansoni DNA helicase recq1 0.0018 0.0007 0.0008
Onchocerca volvulus 0.0097 0.0198 0.0225
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0051 0.0836
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0028 0.0027
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.002 0.0019
Brugia malayi GnHR receptor homolog 0.0132 0.0284 0.0284
Echinococcus granulosus sodium and chloride dependent glycine 0.0165 0.0364 0.0414
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.003 0.0035 0.0603
Brugia malayi hypothetical protein 0.0024 0.0021 0.0021
Schistosoma mansoni myosin xvIII 0.0132 0.0284 0.0324
Echinococcus multilocularis nmda type glutamate receptor 0.0097 0.0198 0.0226
Loa Loa (eye worm) hypothetical protein 0.0028 0.0031 0.0031
Echinococcus multilocularis NMDA receptor 0.0056 0.0099 0.0113
Onchocerca volvulus 0.0021 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Echinococcus multilocularis somatostatin receptor 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Onchocerca volvulus 0.0132 0.0284 0.0324
Brugia malayi vesicular acetylcholine transporter unc-17 0.363 0.8791 0.8791
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0052 0.009 0.0102
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.003 0.0035 0.1271
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.009 0.009
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0051 0.0836
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0039 0.0625
Brugia malayi hypothetical protein 0.0021 0.0014 0.0014
Brugia malayi hypothetical protein 0.0132 0.0284 0.0284
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0004 0.0001
Brugia malayi hypothetical protein 0.0165 0.0364 0.0364
Giardia lamblia DINP protein human, muc B family 0.002 0.0011 0.0644
Onchocerca volvulus 0.0028 0.003 0.0034
Brugia malayi G-protein coupled receptor 0.0132 0.0284 0.0284
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0251 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.0171 0.0378 0.0378
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0004 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0245 0.4322
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0056 0.0099 0.0113
Echinococcus granulosus neuropeptide Y receptor 0.0132 0.0284 0.0324
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0081 0.0093
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0007
Echinococcus multilocularis g protein coupled receptor 0.0132 0.0284 0.0324
Brugia malayi Glutamate receptor 1 precursor 0.0152 0.0331 0.0331
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0105 0.0104
Schistosoma mansoni lamin 0.0028 0.003 0.0034
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0039 0.015
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0134 0.0134
Echinococcus granulosus g protein coupled receptor 0.0132 0.0284 0.0324
Brugia malayi excitatory GABA receptor EXP-1A 0.0052 0.009 0.009
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0081 0.0093
Echinococcus multilocularis carbonic anhydrase II 0.0568 0.1345 0.1529
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.003 0.0035 0.0034
Brugia malayi hypothetical protein 0.0132 0.0284 0.0284
Echinococcus multilocularis bloom syndrome protein 0.0044 0.007 0.008
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0165 0.0364 0.0414
Schistosoma mansoni carbonic anhydrase-related 0.0251 0.0574 0.0652
Echinococcus granulosus 6 phosphofructokinase 0.0116 0.0245 0.0278
Schistosoma mansoni hypothetical protein 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0051
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0116 0.0245 0.4608
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0971 0.2325 0.2644
Schistosoma mansoni loxhd1 0.0021 0.0014 0.0016
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0052 0.009 0.009
Leishmania major hypothetical protein, conserved 0.0036 0.0051 0.005
Leishmania major cytochrome p450-like protein 0.0039 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Brugia malayi Cytochrome P450 family protein 0.0039 0.0057 0.0057
Loa Loa (eye worm) carbonic anhydrase 3 0.0568 0.1345 0.1345
Plasmodium falciparum carbonic anhydrase 0.0251 0.0574 1
Trypanosoma cruzi C-8 sterol isomerase, putative 0.4127 1 1
Brugia malayi Cation transporter family protein 0.0126 0.027 0.027
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0051 0.0845
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0132 0.0284 0.0324
Schistosoma mansoni blooms syndrome DNA helicase 0.0035 0.0048 0.0054
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0251 0.0574 0.0574
Onchocerca volvulus 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.013
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0051 0.0917
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0082 0.1507
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.003 0.0035 0.0603
Brugia malayi Pre-SET motif family protein 0.0031 0.0038 0.0038
Echinococcus multilocularis g protein coupled receptor 0.0132 0.0284 0.0324
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0052 0.009 0.0102
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.003 0.0035 0.1271
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0132 0.0284 0.0284
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0134 0.0131
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.003 0.0035 0.0032
Schistosoma mansoni biogenic amine receptor 0.0132 0.0284 0.0324
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.0284 0.0324
Plasmodium falciparum thioredoxin reductase 0.0017 0.0004 0.0018
Echinococcus granulosus allatostatin A receptor 0.0132 0.0284 0.0324
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0051 0.005
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0051
Schistosoma mansoni neuropeptide receptor 0.0132 0.0284 0.0324
Echinococcus granulosus neuropeptides capa receptor 0.0132 0.0284 0.0324
Echinococcus granulosus somatostatin receptor 0.0132 0.0284 0.0324
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0004 0.0003
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0052 0.009 0.0102
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0105 0.012
Schistosoma mansoni hypothetical protein 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.013
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.003 0.0035 0.1271
Schistosoma mansoni nAChR subunit 0.0052 0.009 0.0102
Brugia malayi RNA binding protein 0.0065 0.0121 0.0121
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0121 0.0138
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0081 0.0093
Echinococcus multilocularis synaptic vesicular amine transporter 0.0383 0.0895 0.1018
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.003 0.0035 0.1271
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.0057 0.0057
Echinococcus granulosus neuropeptide receptor A26 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0165 0.0364 0.0364
Echinococcus granulosus metabotropic glutamate receptor 2 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.1008 0.2415 0.2415
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0056 0.0099 0.0113
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.0284 0.0324
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0018 0.0007 0.0007
Onchocerca volvulus 0.0021 0.0014 0.0016
Echinococcus granulosus nuclear factor of activated T cells 5 0.0079 0.0154 0.0175
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0132 0.0284 0.0324
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0111 0.0232 0.4101
Echinococcus granulosus glutamate receptor 2 0.0167 0.0369 0.042
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0051
Echinococcus multilocularis dro:myosuppressin receptor 0.0132 0.0284 0.0324
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.0284 0.0324
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0039 0.0625
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0132 0.0284 0.0324
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0568 0.1345 0.1529
Trypanosoma brucei C-14 sterol reductase, putative 0.0098 0.0202 0.0199
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0008
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0167 0.0369 0.042
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0008
Onchocerca volvulus 0.0016 0.0001 0.0001
Brugia malayi glutathione reductase 0.0049 0.0082 0.0082
Echinococcus granulosus vesicular acetylcholine transporter 0.363 0.8791 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.009
Echinococcus granulosus carbonic anhydrase 0.0251 0.0574 0.0652
Schistosoma mansoni cytochrome P450 0.003 0.0035 0.0039
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0165 0.0364 0.0414
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0011 0.0012
Loa Loa (eye worm) animal heme peroxidase 0.0069 0.013 0.013
Echinococcus granulosus peroxidasin 0.0069 0.013 0.0148
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0126 0.0269 0.0306
Echinococcus granulosus microtubule associated protein 2 0.1416 0.3407 0.3875
Onchocerca volvulus 0.0024 0.0021 0.0024
Loa Loa (eye worm) serotonin transporter b 0.0971 0.2325 0.2325
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0039 0.0995
Echinococcus granulosus RUN 0.0021 0.0014 0.0016
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0132 0.0284 0.0324
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0082 0.0081
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0028 0.0025
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0105 0.0105
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0077 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0121 0.0138
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0014 0.0014
Toxoplasma gondii ABC1 family protein 0.0036 0.0051 0.0843
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0039 0.156
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0134 0.0133
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0038 0.0043
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.003 0.0035 0.1271
Echinococcus multilocularis 6 phosphofructokinase 0.0116 0.0245 0.0278
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.0245 0.0244
Brugia malayi hypothetical protein 0.0132 0.0284 0.0284
Onchocerca volvulus 0.0132 0.0284 0.0324
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0018 0.0007 0.0008
Echinococcus granulosus g-protein coupled receptor 0.0132 0.0284 0.0324
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0021 0.0021
Plasmodium vivax amine transporter, putative 0.0165 0.0364 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0011 0.0144
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Brugia malayi hypothetical protein 0.0069 0.013 0.013
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0049 0.0081 0.0093
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0057 0.0057
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0126 0.027 0.0307
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Schistosoma mansoni neuropeptide receptor 0.0132 0.0284 0.0324
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0003 0.0002
Echinococcus multilocularis orexin receptor type 2 0.0132 0.0284 0.0324
Brugia malayi ORL1-like opioid receptor 0.0132 0.0284 0.0284
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Echinococcus multilocularis sodium and chloride dependent glycine 0.0165 0.0364 0.0414
Onchocerca volvulus 0.0132 0.0284 0.0324
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.0284 0.0324
Echinococcus granulosus serotonin receptor 0.0132 0.0284 0.0324
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0011 0.0008
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.003 0.0035 0.1271
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Echinococcus granulosus receptor type guanylyl cyclase 0.0016 0.0001 0.0001
Toxoplasma gondii thioredoxin reductase 0.0049 0.0082 0.1386
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.003 0.0035 0.1271
Loa Loa (eye worm) hypothetical protein 0.0027 0.0028 0.0028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.0284 0.0324
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0132 0.0284 0.0324
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0011 0.0011
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0132 0.0284 0.0324
Brugia malayi Peroxidasin 0.0069 0.013 0.013
Echinococcus multilocularis musashi 0.0028 0.003 0.0034
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0132 0.0284 0.0324
Loa Loa (eye worm) CYP4Cod1 0.0039 0.0057 0.0057
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0051 0.0917
Echinococcus multilocularis neuropeptide Y receptor 0.0132 0.0284 0.0324
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0105 0.1791
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0165 0.0364 0.632
Brugia malayi Animal haem peroxidase family protein 0.0069 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Schistosoma mansoni inositol monophosphatase 0.0111 0.0232 0.0264
Loa Loa (eye worm) hypothetical protein 0.0165 0.0364 0.0364
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0134 0.0152
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0105 0.1817
Brugia malayi Glutamate receptor 2 precursor 0.0152 0.0331 0.0331
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0051 0.0058
Loa Loa (eye worm) hypothetical protein 0.0031 0.0038 0.0038
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.0235 0.4423
Schistosoma mansoni opsin-like receptor 0.0132 0.0284 0.0324
Onchocerca volvulus 0.0132 0.0284 0.0324
Echinococcus granulosus orexin receptor type 2 0.0132 0.0284 0.0324
Brugia malayi Uncoordinated protein 44 0.0015 0.0000000053194 0.0000000053194
Leishmania major sterol C-24 reductase, putative 0.0051 0.0087 0.0086
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.0245 0.0278
Echinococcus granulosus tachykinin peptides receptor 99D 0.0132 0.0284 0.0324
Onchocerca volvulus Peroxidase homolog 0.0069 0.013 0.0148
Echinococcus granulosus 7TM GPCR rhodopsin 0.0132 0.0284 0.0324
Onchocerca volvulus Putative nachr subunit 0.0052 0.009 0.0102
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0051 0.0048
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.003 0.0035 0.0603
Echinococcus multilocularis carbonic anhydrase 0.0251 0.0574 0.0652
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0052 0.009 0.0102
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.0057 0.0065
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.0265 0.5003
Loa Loa (eye worm) beta-lactamase 0.0036 0.0051 0.0051
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.009 0.009
Schistosoma mansoni metabotropic glutamate receptor 0.0016 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0028 0.0031 0.124
Brugia malayi Serotonin receptor 0.0132 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Echinococcus granulosus glycine receptor subunit alpha 1 0.0052 0.009 0.0102
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.009
Echinococcus multilocularis sodium and chloride dependent glycine 0.0165 0.0364 0.0414
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0167 0.0369 0.042
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0322 0.0746 0.0848
Echinococcus multilocularis geminin 0.1035 0.2481 0.2822
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0057 0.0057
Echinococcus granulosus carbonic anhydrase 0.0251 0.0574 0.0652
Brugia malayi hypothetical protein 0.0016 0.0001 0.0001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.0338 0.0338
Brugia malayi Cytochrome P450 family protein 0.0039 0.0057 0.0057
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0003 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0121 0.0138
Brugia malayi Thioredoxin reductase 0.0049 0.0082 0.0082
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0132 0.0284 0.0324
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0097 0.0198 0.0225
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.003 0.0035 0.1271
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0167 0.0369 0.042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0077 0.0087
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0165 0.0364 0.0414
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0052 0.009 0.0102
Echinococcus multilocularis carbonic anhydrase 0.0251 0.0574 0.0652
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.003 0.0035 0.0603
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0111 0.0232 0.0232
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.0245 0.0278
Plasmodium falciparum glutathione reductase 0.0017 0.0004 0.0018
Schistosoma mansoni acetylcholine receptor-related 0.0024 0.0021 0.0024
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0132 0.0284 0.0324
Echinococcus granulosus neuropeptide receptor 0.0132 0.0284 0.0324
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0167 0.0369 0.042
Echinococcus granulosus neuropeptide s receptor 0.0132 0.0284 0.0324
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0028 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.1035 0.2481 0.2822
Echinococcus granulosus inositol monophosphatase 1 0.0111 0.0232 0.0264
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0039 0.0629
Brugia malayi Protein kinase domain containing protein 0.0015 0.0000000053194 0.0000000053194
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0004 0.0001
Echinococcus granulosus glutamate receptor subunit protein glur 0.0056 0.0099 0.0113
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0132 0.0284 0.0324
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0039 0.0968
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0132 0.0284 0.0324
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0004 0.0003
Schistosoma mansoni adenoreceptor 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0165 0.0364 0.0364
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0111 0.0232 0.0232
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0011 0.0012
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0102 0.0211 0.0211
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0105 0.0102
Loa Loa (eye worm) hypothetical protein 0.2109 0.5093 0.5093
Brugia malayi Inositol-1 0.0111 0.0232 0.0232
Schistosoma mansoni carbonic anhydrase-related 0.0251 0.0574 0.0652
Mycobacterium ulcerans 6-phosphofructokinase 0.0116 0.0245 1
Brugia malayi G protein-coupled receptor 0.0132 0.0284 0.0284
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0014 0.0016
Brugia malayi hypothetical protein 0.0132 0.0284 0.0284
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0062 0.007
Leishmania major DNA polymerase eta, putative 0.002 0.0011 0.001
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0165 0.0364 0.0414
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0018 0.0007 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0971 0.2325 0.2325
Echinococcus granulosus single minded 2 0.0041 0.0063 0.0072
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0004 0.0003
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Onchocerca volvulus 0.0165 0.0364 0.0414
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0011 0.0011
Treponema pallidum sodium- and chloride- dependent transporter 0.0971 0.2325 1
Plasmodium vivax glutathione reductase, putative 0.0049 0.0082 0.2192
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0052 0.009 0.009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0132 0.0284 0.0324
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0039 0.0057 0.2215
Schistosoma mansoni hypothetical protein 0.0049 0.0081 0.0093
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0024 0.0021 0.0024
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0011 0.001
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0087 0.0098
Loa Loa (eye worm) GABA receptor subunit 0.0028 0.0031 0.0031
Loa Loa (eye worm) ACC-1 protein 0.0052 0.009 0.009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0038 0.0043
Loa Loa (eye worm) hypothetical protein 0.0049 0.0081 0.0081
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0077 0.0077
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0051 0.0714
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0167 0.0369 0.042
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0132 0.0284 0.0284
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0568 0.1345 0.1529
Toxoplasma gondii hypothetical protein 0.0165 0.0364 0.632
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0051
Schistosoma mansoni amine GPCR 0.0132 0.0284 0.0324
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.0105 0.4432
Echinococcus granulosus dna polymerase eta 0.002 0.0011 0.0012
Onchocerca volvulus 0.0165 0.0364 0.0414
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0116 0.0245 0.9102
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0165 0.0364 0.0364
Echinococcus granulosus biogenic amine 5HT receptor 0.0132 0.0284 0.0324
Mycobacterium tuberculosis Conserved protein 0.0036 0.0051 0.0917
Echinococcus multilocularis RUN 0.0021 0.0014 0.0016
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0165 0.0364 0.632
Brugia malayi 6-phosphofructokinase 0.0116 0.0245 0.0245
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0004 0.0001
Schistosoma mansoni histamine h1 receptor 0.0132 0.0284 0.0324
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0021 0.0021
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0052 0.009 0.0102
Brugia malayi hypothetical protein 0.0024 0.0021 0.0021
Loa Loa (eye worm) neuropeptide F receptor 0.0132 0.0284 0.0284
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0383 0.0895 0.0895
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.0284 0.0324
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0105 0.0436
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0052 0.009 0.009
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0165 0.0364 0.0414
Brugia malayi neuropeptide F receptor 0.0132 0.0284 0.0284
Schistosoma mansoni growth hormone secretagogue receptor 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0251 0.0574 0.0574
Echinococcus granulosus lamin dm0 0.0028 0.003 0.0034
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0165 0.0364 0.0364
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0121 0.0138
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.003 0.0035 0.0603
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Brugia malayi Receptor family ligand binding region containing protein 0.0016 0.0001 0.0001
Echinococcus granulosus metabotropic glutamate receptor 5 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0126 0.027 0.027
Trichomonas vaginalis esterase, putative 0.0036 0.0051 0.0845
Plasmodium falciparum transporter, putative 0.0165 0.0364 0.632
Schistosoma mansoni tyrosine kinase 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.0284 0.0324
Schistosoma mansoni glutamate receptor AMPA 0.0152 0.0331 0.0377
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.003 0.0035 0.1271
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0004 0.0018
Onchocerca volvulus 0.0132 0.0284 0.0324
Echinococcus granulosus dna polymerase kappa 0.002 0.0011 0.0012
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0111 0.0232 0.4101
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.009 0.009
Trypanosoma cruzi cytochrome p450-like protein, putative 0.003 0.0035 0.0034
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0056 0.0099 0.0113
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0111 0.0232 0.9488
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.0235 0.4423
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0132 0.0284 0.0324
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0077 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.0284 0.0324
Schistosoma mansoni acetylcholine receptor subunit beta 0.0024 0.0021 0.0024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.0284 0.0324
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0132 0.0284 0.0324
Schistosoma mansoni hypothetical protein 0.0132 0.0284 0.0324
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0051 0.0917
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.0245 0.0245
Echinococcus multilocularis serotonin receptor 0.0132 0.0284 0.0324
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0028 0.0439
Onchocerca volvulus 0.0024 0.0021 0.0024
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0011 0.001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.0488 0.0488
Echinococcus granulosus g protein coupled receptor 0.0132 0.0284 0.0324
Echinococcus granulosus tar DNA binding protein 0.0065 0.0121 0.0138
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0000000053194 0.0000000060508
Toxoplasma gondii hypothetical protein 0.0251 0.0574 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0003 0.0003
Echinococcus granulosus glutamate receptor NMDA 0.0081 0.016 0.0182
Onchocerca volvulus Chorion peroxidase homolog 0.0069 0.013 0.0148
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0134 0.0133
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0132 0.0284 0.0324
Onchocerca volvulus 0.0132 0.0284 0.0324
Onchocerca volvulus 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Echinococcus granulosus neuropeptides capa receptor 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Brugia malayi Melatonin receptor type 1A 0.0132 0.0284 0.0284
Mycobacterium tuberculosis Probable reductase 0.0112 0.0235 0.4423
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0134 0.0152
Schistosoma mansoni vesicular acetylcholine transporter 0.363 0.8791 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0018 0.0007 0.0293
Echinococcus multilocularis 0.003 0.0035 0.0039
Echinococcus granulosus fmrfamide receptor 0.0132 0.0284 0.0324
Schistosoma mansoni metabotropic glutamate receptor 0.0016 0.0001 0.0001
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0003
Plasmodium falciparum thioredoxin reductase 0.0049 0.0082 0.1386
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0018 0.0007 0.007
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0028 0.0031 0.0031
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.1008 0.2415 0.2415
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0052 0.009 0.009
Brugia malayi phosphofructokinase 0.0116 0.0245 0.0245
Trypanosoma cruzi sterol C-24 reductase, putative 0.0051 0.0087 0.0086
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0167 0.0369 0.042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0003
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0051 0.1955
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0003
Schistosoma mansoni carbonic anhydrase-related 0.0251 0.0574 0.0652
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.013
Brugia malayi G-protein coupled receptor 0.0132 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0165 0.0364 0.0364
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0052 0.009 0.0102
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.003 0.0035 0.1271
Schistosoma mansoni ap endonuclease 0.0059 0.0105 0.012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Mycobacterium tuberculosis Conserved protein 0.0036 0.0051 0.0917
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.0265 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0132 0.0284 0.0324
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0034 0.0551
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.003 0.0035 0.0603
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0008
Echinococcus granulosus 7tm_1 domain containing protein 0.0132 0.0284 0.0324
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.013
Echinococcus granulosus tm gpcr rhodopsin 0.0132 0.0284 0.0324
Leishmania major hypothetical protein, conserved 0.0027 0.0028 0.0027
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.0057 0.0947
Schistosoma mansoni neuropeptide F-like receptor 0.0132 0.0284 0.0324
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0014 0.0016
Echinococcus granulosus sex peptide receptor 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.0245 0.0242
Brugia malayi Cytochrome P450 family protein 0.003 0.0035 0.0035
Schistosoma mansoni neuropeptide receptor 0.0132 0.0284 0.0324
Trypanosoma brucei C-8 sterol isomerase, putative 0.4127 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0077 0.0087
Brugia malayi Animal haem peroxidase family protein 0.0069 0.013 0.013
Schistosoma mansoni carbonic anhydrase 0.0251 0.0574 0.0652
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Echinococcus multilocularis glycine receptor subunit beta 0.0052 0.009 0.0102
Schistosoma mansoni hypothetical protein 0.0021 0.0014 0.0016
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0245 0.4322
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0038 0.0043
Loa Loa (eye worm) RGC/RGC protein kinase 0.0016 0.0001 0.0001
Trichomonas vaginalis DNA helicase recq1, putative 0.0044 0.007 0.1186
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0245 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0008
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.0219 0.0219
Brugia malayi beta-lactamase family protein 0.0036 0.0051 0.0051
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0132 0.0284 0.0324
Onchocerca volvulus 0.0069 0.013 0.0148
Loa Loa (eye worm) hypothetical protein 0.0028 0.0031 0.0031
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0121 0.0138
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0111 0.0232 0.0229
Echinococcus granulosus nmda type glutamate receptor 0.0097 0.0198 0.0226
Schistosoma mansoni opsin-like receptor 0.0132 0.0284 0.0324
Onchocerca volvulus 0.0132 0.0284 0.0324
Brugia malayi cytochrome P450 0.003 0.0035 0.0035
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0167 0.0369 0.042
Leishmania major ATP-dependent phosphofructokinase 0.0116 0.0245 0.0244
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0024 0.0021 0.0021
Echinococcus multilocularis neuropeptide s receptor 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0028 0.0031 0.0031
Brugia malayi Cytochrome P450 family protein 0.003 0.0035 0.0035
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0016 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.0284 0.0324
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0003
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0132 0.0284 0.0324
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0052 0.009 0.0102
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Onchocerca volvulus 0.0126 0.027 0.0307
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0165 0.0364 0.0414
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0065 0.0074
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Echinococcus granulosus tm gpcr rhodopsin 0.0132 0.0284 0.0324
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0165 0.0364 0.0364
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0082 0.2192
Echinococcus granulosus glutamate NMDA receptor subunit 0.0322 0.0746 0.0848
Onchocerca volvulus 0.0132 0.0284 0.0324
Schistosoma mansoni neurotransmitter gated ion channel 0.0024 0.0021 0.0024
Schistosoma mansoni glutamate receptor kainate 0.0152 0.0331 0.0377
Echinococcus multilocularis neuropeptides capa receptor 0.0132 0.0284 0.0324
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0024 0.0021 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0028 0.0031 0.0031
Schistosoma mansoni nAChR subunit 0.0052 0.009 0.0102
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0008
Schistosoma mansoni tyrosine kinase 0.0016 0.0001 0.0001
Schistosoma mansoni peroxidasin 0.0069 0.013 0.0148
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.0235 0.4423
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0039 0.0625
Schistosoma mansoni lamin 0.0028 0.003 0.0034
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0003 0.0002
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0051 0.1955
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.363 0.8791 0.8791
Brugia malayi Receptor family ligand binding region containing protein 0.0016 0.0001 0.0001
Onchocerca volvulus 0.0052 0.009 0.0102
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0251 0.0574 0.0574
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.0284 0.0324
Schistosoma mansoni neuropeptide f receptor 76f 0.0132 0.0284 0.0324
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0004 0.0005
Brugia malayi Tachykinin-like peptides receptor 99D 0.0132 0.0284 0.0284
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0024 0.0021 0.0024
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.003 0.0035 0.1271
Echinococcus multilocularis glutamate receptor NMDA 0.0081 0.016 0.0182
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.003 0.0035 0.1271
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0011 0.0117
Brugia malayi hypothetical protein 0.0021 0.0014 0.0014
Schistosoma mansoni opsin-like receptor 0.0132 0.0284 0.0324
Schistosoma mansoni amine GPCR 0.0132 0.0284 0.0324
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0014 0.019
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0052 0.009 0.0102
Loa Loa (eye worm) solute carrier family 6 member 4 0.0971 0.2325 0.2325
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0004 0.0003
Schistosoma mansoni alpha-1 adrenergic receptor 0.0132 0.0284 0.0324
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0035 0.004
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.003 0.0035 0.1271
Schistosoma mansoni nAChR subunit 0.0052 0.009 0.0102
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0028 0.0031 0.0035
Brugia malayi hypothetical protein 0.0132 0.0284 0.0284
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0165 0.0364 0.0414
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0003 0.0003
Brugia malayi neuropeptide F receptor 0.0132 0.0284 0.0284
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.0057 0.0057
Echinococcus granulosus sodium and chloride dependent glycine 0.0165 0.0364 0.0414
Onchocerca volvulus 0.0132 0.0284 0.0324
Echinococcus granulosus tyrosine kinase 0.0016 0.0001 0.0001
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0111 0.0232 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0132 0.0284 0.0324
Echinococcus granulosus biogenic amine 5HT receptor 0.0132 0.0284 0.0324
Onchocerca volvulus 0.0024 0.0021 0.0024
Onchocerca volvulus Dual oxidase homolog 0.0069 0.013 0.0148
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0245 1
Echinococcus multilocularis inositol monophosphatase 1 0.0111 0.0232 0.0264
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0116 0.0245 0.1037
Loa Loa (eye worm) G-protein coupled receptor 0.0132 0.0284 0.0284
Schistosoma mansoni amine GPCR 0.0132 0.0284 0.0324
Loa Loa (eye worm) intermediate filament protein 0.0028 0.003 0.003
Echinococcus granulosus hypothetical protein 0.0132 0.0284 0.0324
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0132 0.0284 0.0284
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0132 0.0284 0.0324
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0038 0.0043
Loa Loa (eye worm) blistered cuticle protein 3 0.0069 0.013 0.013
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0081 0.0081
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0568 0.1345 0.1344
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0568 0.1345 0.1344
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0011 0.0117
Loa Loa (eye worm) hypothetical protein 0.0035 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Schistosoma mansoni sodium/chloride dependent transporter 0.0971 0.2325 0.2644
Brugia malayi hypothetical protein 0.0132 0.0284 0.0284
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0132 0.0284 0.0284
Echinococcus multilocularis microtubule associated protein 2 0.1416 0.3407 0.3875
Brugia malayi Serotonin receptor 0.0132 0.0284 0.0284
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.003 0.0035 0.1271
Echinococcus granulosus glycine receptor subunit beta 0.0052 0.009 0.0102
Loa Loa (eye worm) cytochrome P450 0.003 0.0035 0.0035
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0051 0.0845
Schistosoma mansoni rab6-interacting 0.0021 0.0014 0.0016
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0052 0.009 0.009
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0081 0.0093
Loa Loa (eye worm) LGC-31 protein 0.0052 0.009 0.009
Trichomonas vaginalis set domain proteins, putative 0.0246 0.0561 1
Echinococcus multilocularis neuropeptide receptor 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Onchocerca volvulus 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.009
Toxoplasma gondii hypothetical protein 0.0165 0.0364 0.632
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0612 0.1452 0.1452
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0251 0.0574 0.0574
Leishmania major C-14 sterol reductase, putative 0.0098 0.0202 0.0201
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Onchocerca volvulus 0.0069 0.013 0.0148
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0028 0.0695
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0007 0.0007
Echinococcus multilocularis serotonin receptor 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Schistosoma mansoni ATP-binding cassette transporter 0.0152 0.0331 0.0377
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0011 0.0271
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0245 1
Echinococcus granulosus lamin b receptor 0.0098 0.0202 0.0229
Toxoplasma gondii cytochrome p450 superfamily protein 0.003 0.0035 0.0554
Brugia malayi 6-phosphofructokinase 0.0116 0.0245 0.0245
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.002 0.0288
Loa Loa (eye worm) hypothetical protein 0.0165 0.0364 0.0364
Mycobacterium ulcerans hypothetical protein 0.0036 0.0051 0.1955
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0014 0.0016
Brugia malayi beta-lactamase family protein 0.0036 0.0051 0.0051
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0051 0.0051
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0011 0.0008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0105 0.0104
Loa Loa (eye worm) hypothetical protein 0.0028 0.0031 0.0031
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0105 0.0105
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0038 0.0043
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0052 0.009 0.0102
Leishmania major lanosterol 14-alpha-demethylase, putative 0.003 0.0035 0.0034
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0039 0.0625
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0011 0.0012
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0028 0.0027
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0004 0.0018
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0077 0.0077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0051 0.0058
Echinococcus granulosus geminin 0.1035 0.2481 0.2822
Brugia malayi hypothetical protein 0.0017 0.0005 0.0005
Brugia malayi Doublecortin family protein 0.0021 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0105 0.0219 0.0249
Schistosoma mansoni glutamate receptor AMPA 0.0152 0.0331 0.0377
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0008
Trypanosoma brucei unspecified product 0.002 0.0011 0.0008
Schistosoma mansoni nAChR subunit 0.0052 0.009 0.0102
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0011 0.0011
Brugia malayi hypothetical protein 0.0132 0.0284 0.0284
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0105 0.4281
Brugia malayi Death domain containing protein 0.0015 0.0000000053194 0.0000000053194
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0568 0.1345 0.1345
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0971 0.2325 0.2325
Loa Loa (eye worm) hypothetical protein 0.0028 0.0031 0.0031
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.003 0.0035 0.1271
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.0284 0.0324
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0051 0.005
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.003 0.0035 0.0603
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.009
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0003 0.0003
Schistosoma mansoni protein kinase 0.0016 0.0001 0.0001
Echinococcus granulosus G protein coupled receptor 139 0.0132 0.0284 0.0324
Schistosoma mansoni biogenic amine receptor 0.0132 0.0284 0.0324
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Echinococcus granulosus glutamate receptor 2 0.0111 0.0233 0.0265
Schistosoma mansoni biogenic amine (5HT) receptor 0.0132 0.0284 0.0324
Onchocerca volvulus 0.0165 0.0364 0.0414
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0052 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0251 0.0574 0.0574
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0018 0.0007 0.0008
Echinococcus granulosus alpha 1A adrenergic receptor 0.0132 0.0284 0.0324
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0035 0.0896
Echinococcus granulosus neuropeptide Y receptor 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.009
Echinococcus multilocularis G protein coupled receptor 139 0.0468 0.1101 0.1252
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.009
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.0284 0.0324
Echinococcus granulosus neuropeptide receptor 0.0468 0.1101 0.1252
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.003 0.0035 0.0603
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.003 0.0035 0.1271
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0052 0.009 0.0102
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0132 0.0284 0.0284
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0011 0.001
Schistosoma mansoni DNA polymerase eta 0.002 0.0011 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.009
Echinococcus granulosus serotonin transporter 0.0971 0.2325 0.2644
Schistosoma mansoni hypothetical protein 0.003 0.0035 0.0039
Schistosoma mansoni nAChR subunit 0.0024 0.0021 0.0024
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.013
Echinococcus granulosus g protein coupled receptor 0.0132 0.0284 0.0324
Trypanosoma brucei carbonic anhydrase-like protein 0.0568 0.1345 0.1342
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0011 0.0144
Onchocerca volvulus Peroxidasin homolog 0.0069 0.013 0.0148
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0038 0.0614
Schistosoma mansoni hypothetical protein 0.0056 0.0099 0.0113
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Loa Loa (eye worm) RNA binding protein 0.0065 0.0121 0.0121
Schistosoma mansoni intermediate filament proteins 0.0028 0.003 0.0034
Onchocerca volvulus 0.0036 0.0051 0.0058
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0111 0.0232 0.0232
Schistosoma mansoni nAChR subunit 0.0052 0.009 0.0102
Trypanosoma cruzi sterol C-24 reductase, putative 0.0051 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0039 0.0625
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Plasmodium vivax hypothetical protein, conserved 0.0165 0.0364 1
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0039 0.0629
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0024 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0056 0.0099 0.0113
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0052 0.009 0.0102
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.013
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.003 0.0035 0.0603
Schistosoma mansoni DNA helicase recq5 0.0018 0.0007 0.0008
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.0235 0.4423
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0051
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0011 0.001
Trypanosoma brucei cytochrome P450, putative 0.0039 0.0057 0.0054
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0051 0.0845
Schistosoma mansoni biogenic amine receptor 0.0132 0.0284 0.0324
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0134 0.0152
Loa Loa (eye worm) RecQ helicase 0.0044 0.007 0.007
Echinococcus multilocularis receptor type guanylyl cyclase 0.0016 0.0001 0.0001
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0052 0.009 0.009
Schistosoma mansoni nAChR subunit 0.0052 0.009 0.0102
Schistosoma mansoni biogenic amine (5HT) receptor 0.0132 0.0284 0.0324
Echinococcus multilocularis neuropeptide Y receptor 0.0132 0.0284 0.0324
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0051 0.0845
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0052 0.009 0.0102
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0052 0.009 0.0102
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0057 0.0057
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0056 0.0099 0.0113
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0105 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0052 0.009 0.0102
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0132 0.0284 0.0324
Echinococcus multilocularis carbonic anhydrase 0.0251 0.0574 0.0652
Brugia malayi hypothetical protein 0.0132 0.0284 0.0284
Loa Loa (eye worm) RGC/RGC protein kinase 0.0016 0.0001 0.0001
Loa Loa (eye worm) animal heme peroxidase 0.0069 0.013 0.013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.0284 0.0324
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0105 0.2835
Schistosoma mansoni hypothetical protein 0.0251 0.0574 0.0652
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0245 0.4322
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.0284 0.0324
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.003 0.0035 0.1271
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0052 0.009 0.009
Brugia malayi Animal haem peroxidase family protein 0.0069 0.013 0.013
Trichomonas vaginalis inositol monophosphatase, putative 0.0111 0.0232 0.4101
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.0284 0.0324
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0054 0.2089
Onchocerca volvulus 0.0132 0.0284 0.0324
Leishmania major cytochrome p450-like protein 0.003 0.0035 0.0034
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.009
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0121 0.0121
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0011 0.001
Echinococcus multilocularis GPCR, family 2 0.0049 0.0081 0.0093
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0039 0.0629
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0004 0.0004
Schistosoma mansoni neurotransmitter gated ion channel 0.0024 0.0021 0.0024
Mycobacterium ulcerans beta-lactamase 0.0036 0.0051 0.1955
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0004 0.0029
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Brugia malayi Dopamine receptor 0.0132 0.0284 0.0284
Toxoplasma gondii exonuclease III APE 0.0059 0.0105 0.1791
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0039 0.0629
Echinococcus granulosus survival motor neuron protein 1 0.0474 0.1117 0.127
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0165 0.0364 0.0414
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0065 0.0074
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0165 0.0364 0.632
Echinococcus granulosus atrial natriuretic peptide receptor 0.0016 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0038 0.0043
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.0057 0.0065
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.009
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0165 0.0364 0.0364
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0132 0.0284 0.0284
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0111 0.0232 0.4019
Brugia malayi Metabotropic glutamate receptor precursor. 0.0016 0.0001 0.0001
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0028 0.0031 0.0031
Brugia malayi intermediate filament protein 0.0028 0.003 0.003
Echinococcus multilocularis neuropeptide FF receptor 2 0.0132 0.0284 0.0324
Schistosoma mansoni lipoxygenase 0.0126 0.0269 0.0306
Schistosoma mansoni amine GPCR 0.0132 0.0284 0.0324
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.003 0.0035 0.0034
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0004 0.002
Schistosoma mansoni lipoxygenase 0.0088 0.0177 0.0201
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0052 0.009 0.0102
Echinococcus granulosus nAChR subunit 0.0052 0.009 0.0102
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0132 0.0284 0.0324
Echinococcus granulosus carbonic anhydrase II 0.0568 0.1345 0.1529
Brugia malayi Animal haem peroxidase family protein 0.0069 0.013 0.013
Schistosoma mansoni sodium-dependent amino acid transporter 0.0165 0.0364 0.0414
Schistosoma mansoni single-minded 0.0051 0.0087 0.0098
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0081 0.0081
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0121 0.0121
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0245 0.4322
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0568 0.1345 0.1345
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284
Leishmania major C-8 sterol isomerase-like protein 0.4127 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0035 0.0035
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0132 0.0284 0.0324
Schistosoma mansoni microtubule-associated protein tau 0.1416 0.3407 0.3875
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0082 0.0093
Loa Loa (eye worm) RGC/RGC protein kinase 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0051
Onchocerca volvulus Peroxidasin homolog 0.0069 0.013 0.0148
Schistosoma mansoni polycystin 1-related 0.0021 0.0014 0.0016
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0165 0.0364 0.0414
Trypanosoma cruzi C-14 sterol reductase, putative 0.0098 0.0202 0.0201
Mycobacterium tuberculosis Conserved protein 0.0036 0.0051 0.0917
Brugia malayi G protein-coupled receptor F59B2.13 0.0132 0.0284 0.0284
Schistosoma mansoni peroxidasin 0.0069 0.013 0.0148
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0029
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0167 0.0369 0.042
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0011 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0051 0.0845
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0004 0.0001
Loa Loa (eye worm) inositol-1 0.0111 0.0232 0.0232
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.0235 0.8683
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0011 0.0012
Echinococcus multilocularis fmrfamide receptor 0.0132 0.0284 0.0324
Loa Loa (eye worm) hypothetical protein 0.0132 0.0284 0.0284

Activities

Activity type Activity value Assay description Source Reference
Body weight change (functional) = -3.6 g Mice were inoculated intraperitoneally with L1210 leukemia cells and the change in body weight of the mice with the compound was evaluated at a dose of 800 mg/kg ChEMBL. 6699872
Body weight change (functional) = -2 g Mice were inoculated intraperitoneally with L1210 leukemia cells and the change in body weight of the mice with the compound was evaluated at a dose of 400 mg/kg ChEMBL. 6699872
Body weight change (functional) = -1.4 g Mice were inoculated intraperitoneally with L1210 leukemia cells and the change in body weight of the mice with the compound was evaluated at a dose of 200 mg/kg ChEMBL. 6699872
Body weight change (functional) = -1 g Mice were inoculated intraperitoneally with L1210 leukemia cells and the change in body weight of the mice with the compound was evaluated at a dose of 100 mg/kg ChEMBL. 6699872
Body weight change (functional) = -0.6 g Mice were inoculated intraperitoneally with L1210 leukemia cells and the change in body weight of the mice with the compound was evaluated at a dose of 50 mg/kg ChEMBL. 6699872
ID50 (functional) = 0.0000032 M Compound was evaluated for the cytotoxicty to L1210 leukemia cells in culture at ~1.6-fold higher concentrations and expressed as ID50 ChEMBL. 6699872
ID50 (ADMET) = 10 uM Cytotoxicity against P388 cells in culture ChEMBL. 2856943
ILS (functional) = 36 % Mice were inoculated intraperitoneally with L1210 leukemia cells and the percentage ILS of the mice with the compound was evaluated at a dose of 50 mg/kg ChEMBL. 6699872
ILS (functional) = 83 % Mice were inoculated intraperitoneally with L1210 leukemia cells and the percentage ILS of the mice with the compound was evaluated at a dose of 400 mg/kg ChEMBL. 6699872
ILS (functional) = 86 % Mice were inoculated intraperitoneally with L1210 leukemia cells and the percentage ILS of the mice with the compound was evaluated at a dose of 100 mg/kg ChEMBL. 6699872
ILS (functional) = 96 % Mice were inoculated intraperitoneally with L1210 leukemia cells and the percentage ILS of the mice with the compound was evaluated at a dose of 800 mg/kg ChEMBL. 6699872
ILS (functional) = 159 % Mice were inoculated intraperitoneally with L1210 leukemia cells and the percentage ILS of the mice with the compound was evaluated at a dose of 200 mg/kg ChEMBL. 6699872
Ki (binding) uM In vitro inhibitory activity against pig heart cytoplasmic malate dehydrogenase (MDH); No data ChEMBL. 1969483
Ki (binding) uM In vitro inhibitory activity against pig heart lactate dehydrogenase (LDH); No data ChEMBL. 1969483
Ki (binding) = 65.2 uM In vitro inhibitory activity against bovine liver glutamate dehydrogenase (GDH) ChEMBL. 1969483
Ki (binding) = 105 uM In vitro inhibitory activity against horse liver Alcohol dehydrogenase ChEMBL. 1969483
Median life span (functional) = 11.3 day Mice were inoculated intraperitoneally with L1210 leukemia cells and the median life span of the mice with the compound was evaluated at a dose of 50 mg/kg ChEMBL. 6699872
Median life span (functional) = 15.2 day Mice were inoculated intraperitoneally with L1210 leukemia cells and the median life span of the mice with the compound was evaluated at a dose of 400 mg/kg ChEMBL. 6699872
Median life span (functional) = 15.5 day Mice were inoculated intraperitoneally with L1210 leukemia cells and the median life span of the mice with the compound was evaluated at a dose of 100 mg/kg ChEMBL. 6699872
Median life span (functional) = 16.3 day Mice were inoculated intraperitoneally with L1210 leukemia cells and the median life span of the mice with the compound was evaluated at a dose of 800 mg/kg ChEMBL. 6699872
Median life span (functional) = 21.5 day Mice were inoculated intraperitoneally with L1210 leukemia cells and the median life span of the mice with the compound was evaluated at a dose of 200 mg/kg ChEMBL. 6699872

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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