Detailed information for compound 1865847

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 487.031 | Formula: C27H35ClN2O4
  • H donors: 2 H acceptors: 2 LogP: 4.21 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CN1CCN(CC1)C(C(c1ccc(cc1)OC)O)c1ccccc1.Cl.O
  • InChi: 1S/C27H32N2O3.ClH.H2O/c1-31-24-12-8-21(9-13-24)20-28-16-18-29(19-17-28)26(22-6-4-3-5-7-22)27(30)23-10-14-25(32-2)15-11-23;;/h3-15,26-27,30H,16-20H2,1-2H3;1H;1H2
  • InChiKey: QLSCRYIMVAERIH-UHFFFAOYSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0338 0.1704
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0835 0.3432
Mycobacterium tuberculosis Conserved protein 0.004 0.0475 0.1381
Schistosoma mansoni apoferritin-2 0.0005 0.0022 0.0022
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0209 0.0788
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0049 0.0595 0.0595
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0007 0.004 0.0055
Schistosoma mansoni peptidase Clp (S14 family) 0.0086 0.109 0.109
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0696 0.3544
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0007 0.004 0.0076
Mycobacterium ulcerans monophosphatase CysQ 0.0007 0.004 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1424 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0086 0.109 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0595 0.3026
Loa Loa (eye worm) cysteine protease 0.0029 0.0338 0.0576
Brugia malayi Cathepsin L-like precursor 0.0029 0.0338 0.0576
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0835 0.2479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0338 0.1704
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0086 0.109 0.9708
Brugia malayi Probable ClpP-like protease 0.0086 0.109 0.1859
Brugia malayi MH2 domain containing protein 0.0153 0.1976 0.337
Brugia malayi cathepsin F-like cysteine proteinase 0.0005 0.0022 0.0038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0338 0.1704
Loa Loa (eye worm) hypothetical protein 0.0259 0.3385 0.5775
Schistosoma mansoni kinase 0.0037 0.0435 0.0435
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0086 0.109 1
Onchocerca volvulus Cathepsin L homolog 0.0005 0.0022 0.005
Echinococcus multilocularis cathepsin L 0.0005 0.0022 0.0022
Plasmodium vivax vivapain-2 0.0029 0.0338 0.3093
Mycobacterium leprae POSSIBLE MONOPHOSPHATASE CYSQ 0.0007 0.004 0.0159
Trypanosoma brucei Metacaspase-4 0.0049 0.0595 0.4086
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.109 1
Brugia malayi cytochrome P450 0.0007 0.004 0.0069
Trichomonas vaginalis CAMK family protein kinase 0.0071 0.0898 0.458
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0052 0.0052
Echinococcus granulosus hypothetical protein 0.0038 0.0451 0.0451
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0052 0.0214
Loa Loa (eye worm) latrophilin receptor protein 2 0.0012 0.0108 0.0184
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0064 0.08 0.4079
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0005 0.0022 0.0022
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0029 0.0338 0.0338
Trypanosoma cruzi cytochrome P450, putative 0.0007 0.004 0.0129
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0052 0.0239
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0006 0.0036 0.0134
Onchocerca volvulus 0.0029 0.0338 0.1675
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0835 0.3432
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0007 0.004 0.0129
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0475 0.1381
Onchocerca volvulus 0.004 0.0475 0.2384
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0007 0.004 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0338 0.1704
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0595 0.3026
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0007 0.004 0.004
Trypanosoma brucei metacaspase MCA2 0.0049 0.0595 0.4086
Loa Loa (eye worm) hypothetical protein 0.001 0.0079 0.0134
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0697 0.0697
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0005 0.0022 0.0022
Echinococcus granulosus cysteine protease 0.0015 0.015 0.015
Echinococcus multilocularis muscleblind protein 1 0.0259 0.3385 0.3385
Mycobacterium ulcerans monophosphatase CysQ 0.0007 0.004 0.0074
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0696 0.0696
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0005 0.0022 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0022 0.0085
Echinococcus granulosus cathepsin L 0.0015 0.015 0.015
Brugia malayi F/Y-rich N-terminus family protein 0.0006 0.0034 0.0058
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0007 0.004 0.0076
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0089 0.0151
Schistosoma mansoni cytochrome P450 0.0007 0.004 0.004
Mycobacterium tuberculosis Conserved protein 0.004 0.0475 0.1381
Plasmodium vivax SET domain protein, putative 0.0019 0.0208 0.1901
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0086 0.109 0.109
Echinococcus granulosus geminin 0.0294 0.3847 0.3847
Leishmania major cytochrome p450-like protein 0.0007 0.004 0.0129
Brugia malayi CXXC zinc finger family protein 0.0018 0.0193 0.0329
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.015 0.113
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0038
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0475 0.0811
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0007 0.004 0.0076
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0296 0.2421
Loa Loa (eye worm) hypothetical protein 0.0007 0.004 0.0068
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0209 0.0569
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0338 0.1704
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0052 0.0126
Echinococcus granulosus expressed protein 0.0021 0.0232 0.0232
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0007 0.004 0.0055
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0338 0.0576
Echinococcus multilocularis ferritin 0.0005 0.0022 0.0022
Entamoeba histolytica cysteine protease, putative 0.0015 0.015 0.113
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0505
Trypanosoma cruzi metacaspase, putative 0.0049 0.0595 0.4086
Echinococcus granulosus GPCR family 2 0.0012 0.0108 0.0108
Brugia malayi cathepsin L-like cysteine proteinase 0.0005 0.0022 0.0038
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0697 0.6139
Plasmodium falciparum cysteine proteinase falcipain 1 0.0015 0.015 0.1197
Echinococcus granulosus cathepsin l cysteine peptidase 0.0029 0.0338 0.0338
Brugia malayi Cell death protein 3 precursor 0.0094 0.1195 0.2038
Brugia malayi MAP kinase sur-1 0.0056 0.0696 0.1187
Brugia malayi acetyltransferase, GNAT family protein 0.0109 0.1393 0.2377
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0005 0.0022 0.0197
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0019 0.0209 0.0356
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0595 0.3026
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0012 0.0108 0.0108
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0052 0.0126
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0052 0.0091
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0006 0.0036 0.0102
Brugia malayi cathepsin L-like precursor 0.002 0.021 0.0358
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0835 0.0835
Schistosoma mansoni cathepsin F (C01 family) 0.0029 0.0338 0.0338
Echinococcus multilocularis cathepsin L cysteine protease 0.0029 0.0338 0.0338
Echinococcus granulosus histone acetyltransferase KAT2B 0.0106 0.1353 0.1353
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0007 0.004 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.021 0.1047
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0005 0.0022 0.0085
Schistosoma mansoni pap-inositol-14-phosphatase 0.0007 0.004 0.004
Trypanosoma cruzi cysteine proteinase, putative 0.0015 0.015 0.0912
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0007 0.0038 0.0048
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0128 0.1654 0.1654
Loa Loa (eye worm) hypothetical protein 0.0019 0.0208 0.0354
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0018 0.0192 0.121
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0005 0.0022 0.0197
Mycobacterium leprae Probable lipase LipE 0.004 0.0475 0.4119
Brugia malayi tumor suppressor. 0.0445 0.5862 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0209 0.161
Brugia malayi cathepsin F-like cysteine proteinase 0.001 0.0079 0.0134
Schistosoma mansoni hypothetical protein 0.0294 0.3847 0.3847
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0038
Trichomonas vaginalis inositol monophosphatase, putative 0.0064 0.08 0.4079
Loa Loa (eye worm) cytochrome P450 0.0007 0.004 0.0069
Schistosoma mansoni smad 0.0005 0.0013 0.0013
Echinococcus multilocularis mothers against decapentaplegic 2 0.0005 0.0013 0.0013
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0052 0.0126
Brugia malayi Cathepsin L-like precursor 0.0029 0.0338 0.0576
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.015 0.113
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0209 0.1911
Leishmania major cathepsin L-like protease 0.0029 0.0338 0.2249
Toxoplasma gondii cathepsin CPL 0.0029 0.0338 0.2954
Loa Loa (eye worm) oxidoreductase 0.0008 0.0052 0.0089
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0595 0.3026
Loa Loa (eye worm) MH2 domain-containing protein 0.0153 0.1976 0.337
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0007 0.004 0.0055
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0008 0.0052 0.0126
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0184 0.239 1
Trypanosoma brucei polo-like protein kinase 0.0071 0.0898 0.6245
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0032 0.0375 0.3305
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0209 0.1748
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0091 0.1154 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0071 0.0898 0.7738
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0338 0.1704
Leishmania major cathepsin L-like protease 0.0029 0.0338 0.2249
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0101 0.1296 0.9088
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.015 0.015
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0296 0.1156
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0005 0.0022 0.0085
Entamoeba histolytica cysteine protease, putative 0.0015 0.015 0.113
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0021 0.0226 0.1452
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0052 0.0091
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0052 0.0126
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0696 0.6312
Schistosoma mansoni hypothetical protein 0.0012 0.0108 0.0108
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0005 0.0022 0.0022
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0032 0.0375 0.3437
Mycobacterium ulcerans acetyl-CoA synthetase 0.0008 0.0052 0.0126
Schistosoma mansoni cellular tumor antigen P53 0.0031 0.0368 0.0368
Trichomonas vaginalis set domain proteins, putative 0.0151 0.1953 1
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0088 0.1122 0.3354
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0005 0.0022 0.0038
Brugia malayi Cytochrome P450 family protein 0.0007 0.004 0.0069
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0007 0.004 0.0076
Echinococcus granulosus muscleblind protein 0.0259 0.3385 0.3385
Schistosoma mansoni hypothetical protein 0.0012 0.0108 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0005 0.0022 0.0085
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.015 0.113
Onchocerca volvulus 0.0045 0.0551 0.2774
Entamoeba histolytica cysteine protease, putative 0.0015 0.015 0.113
Schistosoma mansoni hypothetical protein 0.0007 0.004 0.004
Schistosoma mansoni Smad4 0.0005 0.0013 0.0013
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0007 0.004 0.0055
Echinococcus granulosus apoptotic protease activating factor 1 0.0045 0.0551 0.0551
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0296 0.249
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0696 0.0696
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0086 0.109 0.109
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0021 0.0226 0.18
Brugia malayi T-complex protein 1, beta subunit 0.0018 0.0192 0.0327
Schistosoma mansoni ferritin 0.0005 0.0022 0.0022
Loa Loa (eye worm) beta-lactamase 0.004 0.0475 0.0811
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0008 0.0052 0.0126
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0007 0.004 0.0156
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0696 0.0696
Brugia malayi Papain family cysteine protease containing protein 0.0005 0.0022 0.0038
Plasmodium vivax metacaspase 1, putative 0.0049 0.0595 0.5458
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0015 0.015 0.0912
Brugia malayi Cathepsin L-like precursor 0.0029 0.0338 0.0576
Schistosoma mansoni cathepsin s 0.001 0.0079 0.0079
Onchocerca volvulus 0.0019 0.0208 0.1006
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0007 0.004 0.0055
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0195 0.0526
Loa Loa (eye worm) hypothetical protein 0.0006 0.0027 0.0046
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0052 0.0091
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0029 0.0338 0.0338
Brugia malayi Inositol monophosphatase family protein 0.0007 0.004 0.0068
Schistosoma mansoni Smad4 0.0005 0.0013 0.0013
Echinococcus granulosus mothers against decapentaplegic 2 0.0005 0.0013 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1424 1
Schistosoma mansoni caspase-3 (C14 family) 0.0128 0.1654 0.1654
Schistosoma mansoni smad 0.001 0.0089 0.0089
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0475 0.1381
Onchocerca volvulus Cathepsin L homolog 0.0029 0.0338 0.1675
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0012 0.0108 0.0184
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0007 0.004 0.0055
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.021 0.021
Echinococcus multilocularis muscleblind protein 0.0259 0.3385 0.3385
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0475 0.3231
Loa Loa (eye worm) hypothetical protein 0.0049 0.0595 0.1015
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0475 0.2411
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0338 0.1704
Schistosoma mansoni ferritin 0.0005 0.0022 0.0022
Brugia malayi Papain family cysteine protease containing protein 0.0005 0.0022 0.0038
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0007 0.004 0.0055
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0007 0.004 0.0055
Echinococcus multilocularis expressed protein 0.0021 0.0232 0.0232
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0018 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.002 0.021 0.0358
Onchocerca volvulus 0.0008 0.0052 0.0205
Trypanosoma cruzi major cysteine proteinase, putative 0.0087 0.1109 0.7751
Echinococcus multilocularis microtubule associated protein 2 0.0757 1 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0029 0.0338 0.0576
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0007 0.004 0.0076
Leishmania major cathepsin L-like protease 0.0111 0.1424 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0475 0.1381
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0423 0.2142
Trichomonas vaginalis inositol monophosphatase, putative 0.0007 0.004 0.0175
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0029 0.0338 0.2954
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0343 0.3145
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0052 0.0214
Loa Loa (eye worm) ctsf protein 0.0029 0.0338 0.0576
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0338 0.1704
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0064 0.08 0.7287
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0038
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0071 0.0898 0.6245
Plasmodium vivax unspecified product 0.001 0.0079 0.0716
Loa Loa (eye worm) hypothetical protein 0.0007 0.004 0.0068
Loa Loa (eye worm) hypothetical protein 0.0259 0.3385 0.5775
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.015 0.113
Brugia malayi Pre-SET motif family protein 0.0019 0.0208 0.0354
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0006 0.0036 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1424 1
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0475 0.2411
Trichomonas vaginalis CAMK family protein kinase 0.0071 0.0898 0.458
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0252 0.3301 1
Echinococcus granulosus expressed protein 0.0005 0.0022 0.0022
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0018 0.0193 0.0193
Echinococcus granulosus protein quaking 0.0038 0.0451 0.0451
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0338 0.1704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0338 0.1704
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0006 0.0035 0.0035
Mycobacterium tuberculosis Monophosphatase CysQ 0.0007 0.004 0.0053
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0296 0.1156
Mycobacterium ulcerans monophosphatase 0.0007 0.004 0.0074
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0032 0.0375 0.1897
Loa Loa (eye worm) hypothetical protein 0.0037 0.0447 0.0762
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0296 0.1156
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0296 0.0505
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0038
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0052 0.0281
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0595 0.5458
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0008 0.0052 0.0272
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0005 0.0022 0.0197
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0038
Echinococcus multilocularis cathepsin b 0.0005 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0031 0.0368 0.0627
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0012 0.0108 0.0108
Toxoplasma gondii ABC1 family protein 0.004 0.0475 0.4243
Entamoeba histolytica cysteine protease, putative 0.0015 0.015 0.113
Brugia malayi Cathepsin L-like precursor 0.001 0.0079 0.0134
Toxoplasma gondii hypothetical protein 0.0007 0.004 0.0165
Mycobacterium leprae Probable monophosphatase 0.0007 0.004 0.0159
Entamoeba histolytica cysteine proteinase 2 0.0015 0.015 0.113
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0089 0.0151
Loa Loa (eye worm) hypothetical protein 0.001 0.0079 0.0134
Echinococcus multilocularis GPCR, family 2 0.0012 0.0108 0.0108
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0007 0.004 0.0055
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0052 0.0089
Entamoeba histolytica cysteine protease, putative 0.0015 0.015 0.113
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0005 0.0022 0.0022
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0052 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0005 0.0022 0.0085
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0296 0.0505
Schistosoma mansoni caspase-7 (C14 family) 0.0094 0.1195 0.1195
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0052 0.0214
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0296 0.1954
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0007 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0029 0.0338 0.0576
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0015 0.015 0.0912
Plasmodium vivax hypothetical protein, conserved 0.004 0.0475 0.4357
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0052 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.015 0.0741
Onchocerca volvulus 0.0029 0.0338 0.1675
Trypanosoma cruzi cysteine peptidase, putative 0.0111 0.1424 1
Brugia malayi MH2 domain containing protein 0.001 0.0089 0.0151
Schistosoma mansoni caspase-7 (C14 family) 0.0128 0.1654 0.1654
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.021 0.1047
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0835 0.7615
Echinococcus multilocularis caspase 3 0.008 0.101 0.101
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0005 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0086 0.109 0.1859
Loa Loa (eye worm) inositol-1 0.0064 0.08 0.1365
Giardia lamblia Histone acetyltransferase GCN5 0.0029 0.034 0.3627
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0005 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0026 0.029 0.0495
Mycobacterium tuberculosis Conserved protein 0.004 0.0475 0.1381
Mycobacterium leprae Conserved hypothetical protein 0.0007 0.004 0.0164
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0296 0.1954
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0696 0.3544
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.015 0.0741
Loa Loa (eye worm) transcription factor SMAD2 0.0153 0.1976 0.337
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0008 0.0052 0.0126
Echinococcus granulosus ferritin 0.0005 0.0022 0.0022
Echinococcus granulosus histone acetyltransferase KAT2B 0.0032 0.0375 0.0375
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0835 0.5799
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0475 0.2411
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0052 0.0214
Loa Loa (eye worm) hypothetical protein 0.001 0.0079 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0005 0.0022 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0338 0.1704
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1424 1
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0595 0.3026
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0007 0.004 0.0055
Trichomonas vaginalis rotamase, putative 0.0021 0.0226 0.113
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0005 0.0022 0.0022
Plasmodium falciparum T-complex protein 1 subunit beta 0.0018 0.0192 0.1588
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0086 0.109 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0089 0.0089
Schistosoma mansoni microtubule-associated protein tau 0.0757 1 1
Brugia malayi MH1 domain containing protein 0.0006 0.0027 0.0046
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0296 0.1156
Entamoeba histolytica cysteine protease, putative 0.0015 0.015 0.113
Entamoeba histolytica cysteine protease, putative 0.0029 0.0338 0.2787
Plasmodium vivax unspecified product 0.0005 0.0022 0.0197
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.0089
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0052 0.0281
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0133 0.1711 0.2918
Echinococcus multilocularis smad 0.001 0.0089 0.0089
Leishmania major cytochrome p450-like protein 0.0007 0.004 0.0129
Brugia malayi Temporarily assigned gene name protein 44 0.0038 0.0451 0.077
Onchocerca volvulus 0.0005 0.0022 0.005
Loa Loa (eye worm) hypothetical protein 0.004 0.0475 0.0811
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.002 0.002
Echinococcus multilocularis geminin 0.0294 0.3847 0.3847
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.0595 0.5366
Plasmodium vivax vivapain-1 0.0015 0.015 0.1371
Loa Loa (eye worm) hypothetical protein 0.004 0.0475 0.0811
Brugia malayi Calcitonin receptor-like protein seb-1 0.0037 0.0447 0.0762
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0007 0.004 0.0175
Schistosoma mansoni Smad4 0.001 0.0089 0.0089
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0475 0.2411
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0007 0.004 0.0055
Brugia malayi Inositol-1 0.0064 0.08 0.1365
Loa Loa (eye worm) hypothetical protein 0.0019 0.0209 0.0356
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0005 0.0022 0.0197
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0021
Echinococcus granulosus cathepsin L 0.0005 0.0022 0.0022
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0475 0.1381
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0007 0.004 0.0129
Echinococcus multilocularis apoptotic protease activating factor 1 0.0045 0.0551 0.0551
Loa Loa (eye worm) hypothetical protein 0.0094 0.1195 0.2038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0005 0.0022 0.0085
Brugia malayi Cathepsin L-like precursor 0.0029 0.0338 0.0576
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0696 0.4806
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0088 0.1122 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0005 0.0022 0.0085
Trypanosoma cruzi cruzipain precursor, putative 0.0111 0.1424 1
Onchocerca volvulus 0.0014 0.0139 0.0651
Echinococcus multilocularis caspase 8 0.0049 0.0595 0.0595
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0835 0.0835
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0195 0.0526
Leishmania major cysteine peptidase A (CPA) 0.0029 0.0338 0.2249
Echinococcus multilocularis mothers against decapentaplegic 6 0.0005 0.0013 0.0013
Onchocerca volvulus 0.004 0.0475 0.2384
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0697 0.2059
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0338 0.2787
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0064 0.08 0.3285
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0296 0.0505
Trichomonas vaginalis CAMK family protein kinase 0.0071 0.0898 0.458
Trypanosoma cruzi cysteine peptidase, putative 0.0111 0.1424 1
Echinococcus multilocularis cathepsin L 0.0015 0.015 0.015
Trypanosoma cruzi metacaspase, putative 0.0049 0.0595 0.4086
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0362 0.0618
Schistosoma mansoni ferritin 0.0005 0.0022 0.0022
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0343 0.3007
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0475 0.1912
Leishmania major cathepsin L-like protease 0.0111 0.1424 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0475 0.0811
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0007 0.004 0.0076
Schistosoma mansoni smad1 5 8 and 0.001 0.0089 0.0089
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0064 0.08 0.5549
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0595 0.3026
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0005 0.0022 0.0085
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.109 1
Echinococcus granulosus dnaJ subfamily B 0.026 0.3399 0.3399
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0005 0.0022 0.0022
Brugia malayi Muscleblind-like protein 0.0259 0.3385 0.5775
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.109 0.4507
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0007 0.004 0.0076
Brugia malayi serine/threonine-protein kinase plk-2 0.0071 0.0898 0.1531
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0005 0.0022 0.0085
Loa Loa (eye worm) hypothetical protein 0.0019 0.0209 0.0356
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1424 1
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0018 0.0192 0.0955
Trypanosoma cruzi cysteine peptidase, putative 0.0029 0.0338 0.2249
Schistosoma mansoni smad1 5 8 and 0.001 0.0089 0.0089
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0475 0.0475
Plasmodium vivax serine-repeat antigen (SERA) 0.0005 0.0022 0.0197
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0475 0.3231
Leishmania major cathepsin L-like protease 0.0029 0.0338 0.2249
Toxoplasma gondii hypothetical protein 0.003 0.0343 0.3007
Brugia malayi Papain family cysteine protease containing protein 0.0005 0.0022 0.0038
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0086 0.109 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0338 0.1704
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0018 0.0192 0.1754
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0296 0.2421
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0296 0.1954
Giardia lamblia Hypothetical protein 0.0007 0.004 0.0202
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0835 0.3432
Mycobacterium leprae conserved hypothetical protein 0.004 0.0475 0.4119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1424 1
Onchocerca volvulus 0.001 0.0085 0.0372
Trypanosoma cruzi polo-like protein kinase, putative 0.0071 0.0898 0.6245
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0005 0.0022 0.0022
Schistosoma mansoni inositol monophosphatase 0.0064 0.08 0.08
Echinococcus granulosus caspase 0.0128 0.1654 0.1654
Leishmania major cathepsin L-like protease 0.0111 0.1424 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0296 0.2421
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0064 0.08 0.7287
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0007 0.004 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0022 0.0085
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0037 0.0447 0.0762
Onchocerca volvulus 0.0018 0.0193 0.093
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0007 0.004 0.0076
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0007 0.004 0.0055
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.109 1
Trichomonas vaginalis chaperonin, putative 0.0018 0.0192 0.0955
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0296 0.1156
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.004 0.0475 0.0811
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0029 0.0338 0.1704
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0052 0.0052
Brugia malayi Cathepsin L-like precursor 0.002 0.021 0.0358
Plasmodium falciparum metacaspase 1 0.0049 0.0595 0.5366
Schistosoma mansoni cpg binding protein 0.0018 0.0193 0.0193
Trypanosoma cruzi metacaspase 5, putative 0.0049 0.0595 0.4086
Onchocerca volvulus 0.004 0.0475 0.2384
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0208 0.0208
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0006 0.0036 0.0102
Onchocerca volvulus Cathepsin L homolog 0.0029 0.0338 0.1675
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0696 0.4806
Loa Loa (eye worm) hypothetical protein 0.002 0.021 0.0358
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0039 0.0474 0.0474
Echinococcus multilocularis cathepsin L cysteine protease 0.0029 0.0338 0.0338
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0008 0.0052 0.0126
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0007 0.004 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0005 0.0022 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0338 0.1704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0005 0.0022 0.0085
Loa Loa (eye worm) MH1 domain-containing protein 0.0005 0.0013 0.0021
Entamoeba histolytica cysteine protease, putative 0.0015 0.015 0.113
Brugia malayi MH1 domain containing protein 0.0006 0.0027 0.0046
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0007 0.004 0.0076
Echinococcus multilocularis cysteine protease 0.0029 0.0338 0.0338
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0052 0.0091
Mycobacterium ulcerans lipase LipD 0.004 0.0475 0.1912
Loa Loa (eye worm) hypothetical protein 0.002 0.021 0.0358
Loa Loa (eye worm) hypothetical protein 0.0045 0.0551 0.094
Onchocerca volvulus 0.0029 0.0338 0.1675
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0835 0.0835
Echinococcus multilocularis protein quaking 0.0038 0.0451 0.0451
Toxoplasma gondii peptidylprolyl isomerase 0.0021 0.0226 0.1907
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0595 0.3026
Loa Loa (eye worm) papain family cysteine protease containing protein 0.001 0.0079 0.0134
Leishmania major cathepsin L-like protease 0.0029 0.0338 0.2249
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0052 0.0091
Brugia malayi Cathepsin L-like precursor 0.0029 0.0338 0.0576
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0008 0.0052 0.0272
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0595 0.3026
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0696 0.0696
Schistosoma mansoni hypothetical protein 0.0007 0.004 0.004
Trypanosoma brucei protein kinase, putative 0.0056 0.0696 0.4806
Brugia malayi Cytochrome P450 family protein 0.0007 0.004 0.0069
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0007 0.004 0.0129
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0018 0.0192 0.0192
Echinococcus multilocularis caspase 0.0128 0.1654 0.1654
Onchocerca volvulus 0.002 0.021 0.1016
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0007 0.004 0.0076
Brugia malayi Pre-SET motif family protein 0.0133 0.1711 0.2918
Schistosoma mansoni apoferritin-2 0.0005 0.0022 0.0022
Brugia malayi cathepsin B-like cysteine proteinase 0.0005 0.0022 0.0038
Schistosoma mansoni cpg binding protein 0.0019 0.0207 0.0207
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.003 0.0343 0.3006
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0696 0.4806
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0089 0.0089
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0052 0.0091
Trypanosoma brucei metacaspase 0.0049 0.0595 0.4086
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0052 0.0265
Onchocerca volvulus 0.0029 0.0338 0.1675
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0007 0.004 0.0076
Brugia malayi Cathepsin L-like precursor 0.002 0.021 0.0358
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0007 0.004 0.0076
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0007 0.004 0.0055
Schistosoma mansoni ferritin 0.0005 0.0022 0.0022
Echinococcus granulosus inositol monophosphatase 1 0.0064 0.08 0.08
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0021 0.0226 0.1452
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0005 0.0022 0.0197
Giardia lamblia Kinase, PLK 0.0071 0.0898 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0595 0.3026
Onchocerca volvulus Serine\/threonine kinase homolog 0.0071 0.0898 0.4561
Echinococcus granulosus cathepsin l1 0.002 0.021 0.021
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0008 0.0052 0.0126
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.004 0.0069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0338 0.1704
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0052 0.0281
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0007 0.004 0.0055
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0007 0.004 0.0156
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0296 0.1156
Onchocerca volvulus 0.0029 0.0338 0.1675
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0296 0.249
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0008 0.0052 0.0126
Brugia malayi latrophilin 2 splice variant baaae 0.0026 0.029 0.0495
Schistosoma mansoni cathepsin S (C01 family) 0.0005 0.0022 0.0022
Brugia malayi cathepsin Z-like cysteine proteinase 0.0005 0.0022 0.0038
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0007 0.004 0.0175
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0008 0.0052 0.0272
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0032 0.0375 0.3305
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0696 0.4806
Echinococcus granulosus cathepsin b 0.0005 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0209 0.0356
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.0079 0.0403
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0019 0.0208 0.1739
Entamoeba histolytica cysteine protease, putative 0.0015 0.015 0.113
Mycobacterium ulcerans hypothetical protein 0.0026 0.0296 0.1156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0338 0.1704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0338 0.1704
Leishmania major inositol polyphosphate 1-phosphatase, putative 0.0007 0.004 0.0126
Brugia malayi beta-lactamase family protein 0.004 0.0475 0.0811
Echinococcus granulosus mothers against decapentaplegic 6 0.0005 0.0013 0.0013
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0052 0.0091
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0052 0.0089
Schistosoma mansoni myo inositol monophosphatase 0.0007 0.004 0.004
Echinococcus multilocularis dnaJ subfamily B 0.026 0.3399 0.3399
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0029 0.0338 0.2954
Schistosoma mansoni inositol monophosphatase 0.0064 0.08 0.08
Plasmodium vivax vivapain-2 0.0029 0.0338 0.3093
Loa Loa (eye worm) hypothetical protein 0.0019 0.0209 0.0356
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0005 0.0022 0.0038
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0021 0.0226 0.1452
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0005 0.0022 0.0197
Loa Loa (eye worm) hypothetical protein 0.0012 0.0108 0.0184
Echinococcus multilocularis 0.0007 0.004 0.004
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0052 0.0126
Brugia malayi MH2 domain containing protein 0.001 0.0089 0.0151
Plasmodium falciparum histone acetyltransferase GCN5 0.0029 0.034 0.2974
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0005 0.0022 0.0085
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0005 0.0022 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1424 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0338 0.1704
Echinococcus multilocularis cysteine protease 0.0029 0.0338 0.0338
Onchocerca volvulus 0.0026 0.0296 0.1461
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0007 0.004 0.0076
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0475 0.0475
Brugia malayi Cathepsin L-like precursor 0.0029 0.0338 0.0576
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0007 0.004 0.0076
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0696 0.4806
Trypanosoma brucei metacaspase MCA3 0.0049 0.0595 0.4086
Brugia malayi mothers against decapentaplegic homolog 3 0.0005 0.0013 0.0021
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0696 0.3544
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0005 0.0022 0.0197
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0052 0.0214
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0018 0.0192 0.0192
Brugia malayi hypothetical protein 0.0045 0.0551 0.094
Trichomonas vaginalis CAMK family protein kinase 0.0071 0.0898 0.458
Schistosoma mansoni hypothetical protein 0.0045 0.0551 0.0551
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0052 0.0214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0015 0.015 0.0912
Plasmodium vivax serine-repeat antigen (SERA) 0.0005 0.0022 0.0197
Brugia malayi MH1 domain containing protein 0.001 0.0089 0.0151
Onchocerca volvulus 0.0008 0.0052 0.0205
Echinococcus multilocularis tumor protein p63 0.0215 0.2799 0.2799
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0007 0.004 0.0055
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0475 0.1381
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0019 0.0208 0.0208
Brugia malayi Smad1 0.001 0.0089 0.0151
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0057 0.0711 0.2101
Echinococcus multilocularis expressed protein 0.0005 0.0022 0.0022
Echinococcus granulosus cpg binding protein 0.0019 0.0207 0.0207
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0091 0.1154 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0006 0.0035 0.0035
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0005 0.0022 0.0022
Onchocerca volvulus 0.0151 0.1953 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0037 0.0447 0.0762
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0475 0.1912
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0005 0.0022 0.0038
Mycobacterium leprae putative cytochrome p450 0.0007 0.004 0.0164
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.015 0.0256
Schistosoma mansoni cathepsin C 0.0005 0.0022 0.0022
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0696 0.4806
Loa Loa (eye worm) hypothetical protein 0.004 0.0475 0.0811
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0005 0.0022 0.0085
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.109 0.4507
Echinococcus multilocularis inositol monophosphatase 0.0007 0.004 0.004
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0052 0.0091
Schistosoma mansoni cpg binding protein 0.0019 0.0207 0.0207
Echinococcus multilocularis cathepsin b 0.0005 0.0022 0.0022
Brugia malayi cathepsin L precursor 0.0005 0.0022 0.0038
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0696 0.7696
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0052 0.0091
Schistosoma mansoni hypothetical protein 0.0007 0.004 0.004
Brugia malayi hypothetical protein 0.0038 0.0451 0.077
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0052 0.0281
Loa Loa (eye worm) hypothetical protein 0.0038 0.0451 0.077
Loa Loa (eye worm) hypothetical protein 0.004 0.0475 0.0811
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0029 0.0338 0.1704
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0007 0.004 0.0076
Loa Loa (eye worm) hypothetical protein 0.0091 0.1154 0.1968
Schistosoma mansoni hypothetical protein 0.0026 0.029 0.029
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0018 0.0192 0.121
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0005 0.0022 0.0197
Mycobacterium tuberculosis Probable monophosphatase 0.0007 0.004 0.0053
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0109 0.1393 0.1393
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0005 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0038 0.0451 0.0451
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0696 0.0696
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0696 0.1187
Schistosoma mansoni hypothetical protein 0.0012 0.0108 0.0108
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0208 0.0208
Onchocerca volvulus 0.0029 0.0338 0.1675
Trypanosoma cruzi cysteine peptidase, putative 0.0111 0.1424 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0012 0.0108 0.0108
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0007 0.004 0.0129
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0052 0.0214
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0052 0.0473
Onchocerca volvulus 0.0031 0.0368 0.1831
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0595 0.3026
Plasmodium falciparum cysteine proteinase falcipain 3 0.0029 0.0338 0.2954
Echinococcus granulosus Smad4 0.001 0.0089 0.0089
Schistosoma mansoni hypothetical protein 0.0294 0.3847 0.3847
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0338 0.1704
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0007 0.004 0.0055
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0005 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0232 0.1164
Trypanosoma cruzi cruzipain precursor, putative 0.001 0.0079 0.0403
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0005 0.002 0.002
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0089 0.0089
Trypanosoma cruzi polo-like protein kinase, putative 0.0071 0.0898 0.6245
Mycobacterium ulcerans hypothetical protein 0.004 0.0475 0.1912
Trypanosoma cruzi metacaspase, putative 0.0049 0.0595 0.4086
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0595 0.3026
Trypanosoma cruzi cytochrome P450, putative 0.0007 0.004 0.0129
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0005 0.0022 0.0197
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0007 0.004 0.0055
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0052 0.0239
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.003 0.0343 0.2918
Entamoeba histolytica cysteine protease, putative 0.0015 0.015 0.113
Loa Loa (eye worm) cathepsin B 0.0005 0.0022 0.0038
Trypanosoma brucei beta lactamase 0.0088 0.1122 0.7844
Brugia malayi fibroinase precursor 0.0005 0.0022 0.0038
Echinococcus multilocularis caspase 2 0.0094 0.1195 0.1195
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0696 0.4806
Brugia malayi Cytochrome P450 family protein 0.0007 0.004 0.0069
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0007 0.004 0.0129
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative 0.0007 0.004 0.0126
Schistosoma mansoni smad1 5 8 and 0.001 0.0089 0.0089
Plasmodium vivax vivapain-3 0.0015 0.015 0.1371
Leishmania major cytochrome p450-like protein 0.0007 0.004 0.0129
Echinococcus multilocularis inositol monophosphatase 1 0.0064 0.08 0.08
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0012 0.0108 0.0108
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0019 0.0208 0.0208
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0057 0.0711 0.6265
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0052 0.0214
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.015 0.015
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0005 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0005 0.0022 0.0085
Loa Loa (eye worm) fibroinase 0.0029 0.0338 0.0576
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0071 0.0898 0.0898
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.004 0.0069
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.0007 0.004 0.0126
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0052 0.0052
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0835 0.0835
Plasmodium falciparum metacaspase-like protein 0.0049 0.0595 0.5366
Loa Loa (eye worm) acetyltransferase 0.0109 0.1393 0.2377
Trypanosoma brucei cytochrome P450, putative 0.0007 0.004 0.0129
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0109 0.1393 0.1393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0005 0.0022 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0338 0.1704
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0128 0.1654 0.1654
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.0595 0.5366
Loa Loa (eye worm) tumor suppressor 0.0445 0.5862 1
Echinococcus granulosus inositol monophosphatase 0.0007 0.004 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0423 0.2142
Onchocerca volvulus 0.0008 0.0052 0.0205
Loa Loa (eye worm) MH2 domain-containing protein 0.0005 0.0013 0.0021
Echinococcus granulosus caspase 2 0.0094 0.1195 0.1195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1424 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0375 0.1897
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1424 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0038 0.0454 0.4046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0338 0.1704
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0475 0.0475
Onchocerca volvulus Cathepsin F homolog 0.0029 0.0338 0.1675
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0005 0.002 0.002
Leishmania major cathepsin L-like protease 0.0029 0.0338 0.2249
Trichomonas vaginalis esterase, putative 0.004 0.0475 0.2411
Echinococcus granulosus caspase 3 0.008 0.101 0.101
Trichomonas vaginalis rotamase, putative 0.0021 0.0232 0.1164
Trichomonas vaginalis ferritin, putative 0.0005 0.0022 0.0085
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0052 0.0089
Schistosoma mansoni hypothetical protein 0.0012 0.0108 0.0108
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0898 0.0898
Brugia malayi Cathepsin L-like cysteine proteinase 0.002 0.021 0.0358
Brugia malayi MH1 domain containing protein 0.001 0.0089 0.0151
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.015 0.015
Giardia lamblia TCP-1 chaperonin subunit beta 0.0018 0.0192 0.1937
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0089 0.0089
Echinococcus granulosus cathepsin b 0.0005 0.0022 0.0022
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0018 0.0192 0.0192
Onchocerca volvulus 0.0029 0.0338 0.1675
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0018 0.0192 0.0192
Loa Loa (eye worm) T-complex protein 1 0.0018 0.0192 0.0327
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0021 0.0226 0.1452
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0005 0.0022 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0195 0.0526
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0296 0.1156
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0195 0.0526
Leishmania major myo-inositol-1 phosphatase, putative 0.0007 0.004 0.0126
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.0595 0.5366
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0071 0.0898 0.1531
Onchocerca volvulus Cell death protein 3 homolog 0.0094 0.1195 0.6094
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0338 0.2787
Entamoeba histolytica cysteine proteinase, putative 0.002 0.021 0.1657
Schistosoma mansoni ferritin light chain 0.0005 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.026 0.3399 0.3399
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0007 0.004 0.0076
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0697 0.0697
Trypanosoma cruzi cysteine proteinase, putative 0.0015 0.015 0.0912
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0006 0.0036 0.0102
Entamoeba histolytica cysteine proteinase 1, putative 0.0015 0.015 0.113
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0052 0.0091
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0595 0.3026
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0008 0.0052 0.0126
Mycobacterium ulcerans inositol-monophosphatase ImpA 0.0007 0.004 0.0074
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0064 0.08 0.5549
Brugia malayi Inositol monophosphatase family protein 0.0007 0.004 0.0068
Trypanosoma cruzi cysteine protease, putative 0.0015 0.015 0.0912
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0475 0.2411
Brugia malayi beta-lactamase 0.004 0.0475 0.0811
Entamoeba histolytica cysteine protease, putative 0.0015 0.015 0.113
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0475 0.1381
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0064 0.08 0.4079
Trichomonas vaginalis CAMK family protein kinase 0.0071 0.0898 0.458
Loa Loa (eye worm) nuclear factor I 0.0006 0.0027 0.0046
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0052 0.0089
Echinococcus multilocularis Smad4 0.001 0.0089 0.0089
Leishmania major hypothetical protein, conserved 0.004 0.0475 0.3231
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0021 0.0232 0.0396
Loa Loa (eye worm) CYP4Cod1 0.0007 0.004 0.0069
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0052 0.0089
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0064 0.08 0.5549
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0049 0.0595 0.1015
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0296 0.0835
Brugia malayi Latrophilin receptor protein 2 0.0012 0.0108 0.0184
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0064 0.08 0.5549
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0475 0.3231
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0697 0.2059
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0052 0.0091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1424 1
Entamoeba histolytica cysteine protease, putative 0.0015 0.015 0.113
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0064 0.08 0.6876
Schistosoma mansoni cathepsin F (C01 family) 0.0029 0.0338 0.0338
Onchocerca volvulus Inositol monophosphatase 3 homolog 0.0007 0.004 0.0141
Brugia malayi MH2 domain containing protein 0.0005 0.0013 0.0021
Schistosoma mansoni hypothetical protein 0.0038 0.0451 0.0451
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0208 0.0208
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0338 0.1704
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0007 0.004 0.0076
Echinococcus granulosus smad 0.001 0.0089 0.0089
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.109 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0005 0.0022 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1424 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0007 0.004 0.017
Trichomonas vaginalis CAMK family protein kinase 0.0071 0.0898 0.458
Brugia malayi Cytochrome P450 family protein 0.0031 0.0362 0.0618
Schistosoma mansoni ferritin light chain 0.0005 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0038
Echinococcus granulosus caspase 8 0.0049 0.0595 0.0595
Echinococcus granulosus cathepsin l1 0.0029 0.0338 0.0338
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0052 0.0089
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0008 0.0052 0.0126
Trypanosoma cruzi cysteine peptidase, putative 0.0015 0.015 0.0912
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0338 0.1704
Echinococcus granulosus cathepsin L cysteine protease 0.0015 0.015 0.015
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0052 0.0126
Trypanosoma cruzi metacaspase 5, putative 0.0049 0.0595 0.4086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0208 0.0208
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0018 0.0192 0.1499
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0184 0.239 0.7223
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0338 0.1704
Trypanosoma cruzi metacaspase, putative 0.0049 0.0595 0.4086
Trichomonas vaginalis CAMK family protein kinase 0.0071 0.0898 0.458
Echinococcus granulosus cytochrome P450 2K1 0.0007 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.004 0.0475 0.0811
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0052 0.0214
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0007 0.004 0.0055
Entamoeba histolytica acetyltransferase, GNAT family 0.0029 0.034 0.2806
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0475 0.1381
Mycobacterium ulcerans beta-lactamase 0.004 0.0475 0.1912
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0475 0.0475
Mycobacterium ulcerans lipoprotein LpqF 0.0088 0.1122 0.4643
Leishmania major T-complex protein 1, beta subunit, putative 0.0018 0.0192 0.121
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0696 0.3544
Brugia malayi beta-lactamase family protein 0.004 0.0475 0.0811
Toxoplasma gondii t-complex protein beta subunit 0.0018 0.0192 0.1588
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.015 0.0256
Loa Loa (eye worm) CXXC zinc finger family protein 0.0018 0.0193 0.0329
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0005 0.0022 0.0085
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0006 0.0036 0.0102
Loa Loa (eye worm) histone methyltransferase 0.0006 0.0035 0.006
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0089
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0021 0.0232 0.0396
Trichomonas vaginalis inositol monophosphatase, putative 0.0007 0.004 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0595 0.3026
Loa Loa (eye worm) Smad1 0.001 0.0089 0.0151
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0005 0.0022 0.0085
Entamoeba histolytica cysteine protease, putative 0.0015 0.015 0.113
Schistosoma mansoni rotamase 0.0021 0.0232 0.0232
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0296 0.0835
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0029 0.0338 0.0576
Entamoeba histolytica cysteine protease, putative 0.0015 0.015 0.113
Echinococcus granulosus tumor protein p63 0.0215 0.2799 0.2799
Brugia malayi T-complex protein 1, beta subunit 0.0018 0.0192 0.0327
Brugia malayi cathepsin Z-like cysteine proteinase 0.0005 0.0022 0.0038
Trypanosoma brucei inositol polyphosphate 1-phosphatase, putative 0.0007 0.004 0.0126
Echinococcus granulosus cathepsin L cysteine proteinase 0.0029 0.0338 0.0338
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0005 0.0022 0.0197
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0052 0.0089
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0595 0.3026
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0595 0.3026
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0007 0.004 0.0076
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0505
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0505
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.0007 0.004 0.0126
Echinococcus granulosus mixed lineage leukemia protein mll 0.0005 0.002 0.002
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0007 0.004 0.0055
Schistosoma mansoni cathepsin B (C01 family) 0.0005 0.0022 0.0022
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.001 0.0079 0.0134
Plasmodium vivax unspecified product 0.0015 0.015 0.1371
Leishmania major metacaspase, putative 0.0049 0.0595 0.4086
Echinococcus multilocularis cpg binding protein 0.0019 0.0207 0.0207
Trypanosoma brucei metacaspase 5, putative 0.0049 0.0595 0.4086
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0071 0.0898 0.0898

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 160 mg kg-1 Analgesic activity in sc dosed ddN mouse assessed as inhibition of light radiation-induced thermal pain by D'Amour-Smith method ChEMBL. 106119

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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