Detailed information for compound 18729

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 402.934 | Formula: C23H29ClNO3-
  • H donors: 0 H acceptors: 1 LogP: 4.98 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OCCCN1CCC(CC1)c1ccccc1)C(=O)C.[Cl-]
  • InChi: 1S/C23H29NO3.ClH/c1-18(25)21-9-10-22(23(17-21)26-2)27-16-6-13-24-14-11-20(12-15-24)19-7-4-3-5-8-19;/h3-5,7-10,17,20H,6,11-16H2,1-2H3;1H/p-1
  • InChiKey: XWTKVWIHNYNXHD-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0049 0.0147 0.0148
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0049 0.0147 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0095 0.0496
Onchocerca volvulus 0.0114 0.0468 0.0746
Echinococcus multilocularis excitatory amino acid transporter 2 0.0374 0.1768 0.1768
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0114 0.0738
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0003 0.0005
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0234 0.5091
Loa Loa (eye worm) hypothetical protein 0.0053 0.0164 0.03
Brugia malayi Cache domain containing protein 0.0408 0.1934 0.3537
Echinococcus granulosus beta LACTamase domain containing family member 0.0308 0.1436 0.1436
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0308 0.1436 1
Mycobacterium ulcerans beta-lactamase 0.0308 0.1436 1
Brugia malayi nuclear receptor RXR 0.003 0.0053 0.0097
Onchocerca volvulus 0.0025 0.0024 0.0034
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0256 0.1176 0.1208
Echinococcus granulosus cytochrome P450 2K1 0.0049 0.0147 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0035 0.0068
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0094 0.0094
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0095 0.0612
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0029 0.0048 0.0884
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0058 0.0189 0.0345
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0308 0.1436 0.3304
Loa Loa (eye worm) hypothetical protein 0.0038 0.0089 0.0162
Echinococcus multilocularis tissue type plasminogen activator 0.0025 0.0024 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0058 0.0189 0.0345
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0058 0.0189 0.0189
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0086 0.0138
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0095 0.0505
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0143 0.0612 0.0612
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0037 0.0085
Brugia malayi tailless protein 0.0027 0.0037 0.0067
Brugia malayi exodeoxyribonuclease III family protein 0.0078 0.0292 0.0533
Echinococcus granulosus thyroid hormone receptor alpha 0.0027 0.0037 0.0037
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0049 0.0147 0.0971
Brugia malayi cytochrome P450 0.0049 0.0147 0.0268
Echinococcus granulosus intermediate filament protein 0.0114 0.0468 0.0468
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.0118 0.0118
Brugia malayi hypothetical protein 0.0034 0.0072 0.0132
Leishmania major cytochrome p450-like protein 0.0049 0.0147 0.0868
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0069 0.0429
Brugia malayi hypothetical protein 0.0044 0.0118 0.0216
Onchocerca volvulus 0.0044 0.0118 0.0185
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0044
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0089 0.0162
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0049 0.0147 0.1004
Brugia malayi cytoplasmic intermediate filament protein 0.0061 0.0205 0.0374
Brugia malayi von Willebrand factor type A domain containing protein 0.0038 0.0089 0.0162
Loa Loa (eye worm) hypothetical protein 0.0032 0.0061 0.0111
Schistosoma mansoni coup transcription factor 0.0058 0.0189 0.0435
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0069 0.0327
Brugia malayi CXXC zinc finger family protein 0.0058 0.0189 0.0346
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0078 0.0292 0.1985
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.0288 0.987
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0058 0.0189 0.0345
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0018 0.0034
Brugia malayi nuclear receptor RXR 0.0027 0.0037 0.0067
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0058 0.0189 0.0189
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0025 0.0026 0.0013
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0095 0.0175
Schistosoma mansoni smad 0.0034 0.0068 0.0157
Trypanosoma cruzi extracellular receptor, putative 0.0032 0.0061 0.0367
Brugia malayi laminin alpha chain 0.005 0.0151 0.0277
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0884 0.4307 0.9907
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0049 0.0147 0.0148
Echinococcus granulosus excitatory amino acid transporter 3 0.0374 0.1768 0.1768
Loa Loa (eye worm) glutamate receptor 0.0094 0.0372 0.068
Schistosoma mansoni hypothetical protein 0.0823 0.4003 0.9207
Loa Loa (eye worm) hypothetical protein 0.0308 0.1436 0.2626
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0029 0.0048 0.0087
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0049 0.0147 0.1004
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0079 0.0297 0.0297
Echinococcus multilocularis Smad4 0.0034 0.0068 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0095 0.0496
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0078 0.0288 0.0294
Brugia malayi Augmenter of liver regeneration 0.0068 0.024 0.044
Loa Loa (eye worm) hypothetical protein 0.0058 0.0189 0.0345
Schistosoma mansoni cpg binding protein 0.0061 0.0205 0.0473
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0266 0.1228 0.1228
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0308 0.1436 0.2626
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0035 0.0068
Plasmodium vivax multidomain scavenger receptor, putative 0.0044 0.0118 0.0664
Schistosoma mansoni hypothetical protein 0.0053 0.0167 0.0385
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0049 0.0147 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0095 0.0496
Toxoplasma gondii ABC1 family protein 0.0308 0.1436 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1967 0.971 1
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0374 0.1768 0.1818
Loa Loa (eye worm) hypothetical protein 0.0038 0.0089 0.0162
Onchocerca volvulus 0.0058 0.0189 0.0299
Onchocerca volvulus 0.0102 0.0411 0.0655
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0078 0.0292 0.1985
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0038 0.0089 0.0463
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0071 0.0255 0.0466
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0049 0.0147 0.086
Schistosoma mansoni hypothetical protein 0.0053 0.0167 0.0385
Loa Loa (eye worm) hypothetical protein 0.0114 0.0468 0.0855
Echinococcus granulosus geminin 0.0892 0.4347 0.4347
Chlamydia trachomatis neutral amino acid transporter 0.0166 0.0729 0.2976
Echinococcus multilocularis musashi 0.0114 0.0468 0.0468
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0058 0.0189 0.0435
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0032 0.0061 0.0092
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0067
Plasmodium vivax thrombospondin-related anonymous protein 0.0038 0.0089 0.0456
Brugia malayi von Willebrand Factor 0.0038 0.0089 0.0162
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0058 0.0189 0.0435
Schistosoma mansoni tar DNA-binding protein 0.0191 0.0852 0.1961
Onchocerca volvulus 0.0027 0.0037 0.0055
Leishmania major DNA polymerase kappa, putative 0.0039 0.0095 0.0505
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0308 0.1436 0.3304
Trichomonas vaginalis esterase, putative 0.0308 0.1436 0.2303
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0921 0.4494 0.4494
Echinococcus multilocularis dnaJ subfamily B 0.0823 0.4003 0.4003
Schistosoma mansoni nuclear receptor 0.0027 0.0037 0.0085
Mycobacterium ulcerans lipase LipD 0.0308 0.1436 1
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0038 0.0089 0.0142
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0026 0.0122
Schistosoma mansoni glutamate receptor AMPA 0.005 0.0148 0.0341
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0234 0.0539
Brugia malayi Nuclear hormone receptor-like 1 0.0058 0.0189 0.0345
Loa Loa (eye worm) glutamate receptor 0.0249 0.1145 0.2094
Echinococcus granulosus sodium:dicarboxylate symporter 0.0374 0.1768 0.1768
Onchocerca volvulus 0.0308 0.1436 0.2299
Brugia malayi hypothetical protein 0.003 0.0053 0.0097
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0049 0.0147 0.0148
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0161 0.0705 0.1622
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0078 0.0292 0.0292
Echinococcus granulosus neutral amino acid transporter A 0.0374 0.1768 0.1768
Loa Loa (eye worm) hypothetical protein 0.0115 0.0477 0.0871
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.046 0.1059
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0078 0.0288 0.199
Brugia malayi Bloom's syndrome protein homolog 0.0042 0.0111 0.0203
Entamoeba histolytica hypothetical protein 0.0038 0.0089 0.1925
Schistosoma mansoni hypothetical protein 0.0266 0.1228 0.2824
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0166 0.0729 0.0729
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0049 0.0147 0.1004
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0305 0.1422 0.1422
Schistosoma mansoni slit 0.005 0.0151 0.0348
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0058 0.0189 0.0189
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0112 0.046 0.1059
Echinococcus granulosus nuclear receptor nhr 48 0.0027 0.0037 0.0037
Echinococcus multilocularis tar DNA binding protein 0.0191 0.0852 0.0852
Brugia malayi Inositol-1 0.0037 0.0086 0.0157
Schistosoma mansoni lipoxygenase 0.0122 0.0509 0.117
Brugia malayi hypothetical protein 0.003 0.0053 0.0097
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0111 0.0454 0.0454
Echinococcus granulosus tyrosine kinase 0.0032 0.0061 0.0061
Schistosoma mansoni thyroid hormone receptor 0.0324 0.1515 0.3486
Schistosoma mansoni metabotropic glutamate receptor 0.0211 0.0951 0.2187
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0068 0.024 0.024
Onchocerca volvulus 0.0308 0.1436 0.2299
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0029 0.0048 0.0048
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0374 0.1768 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.0697 0.0715
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0049 0.0147 0.1004
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.046 0.046
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0068 0.0068
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0078 0.0292 0.1222
Echinococcus granulosus lamin 0.0114 0.0468 0.0468
Echinococcus multilocularis bloom syndrome protein 0.0042 0.0111 0.0111
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0038 0.0089 0.0162
Toxoplasma gondii aldehyde dehydrogenase 0.0256 0.1176 0.8156
Loa Loa (eye worm) abnormal epIthelia family member 0.005 0.0151 0.0277
Schistosoma mansoni zinc finger protein 0.0027 0.0037 0.0085
Brugia malayi ecdysone receptor 0.0027 0.0037 0.0067
Toxoplasma gondii cytochrome p450 superfamily protein 0.0049 0.0147 0.0875
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0097
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0068 0.024 0.024
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0038 0.0089 0.0162
Schistosoma mansoni hypothetical protein 0.0476 0.2273 0.5229
Onchocerca volvulus 0.0038 0.0089 0.0138
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0068 0.0068
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.0118 0.0118
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0079 0.0297 0.0297
Echinococcus granulosus receptor type guanylyl cyclase 0.0032 0.0061 0.0061
Echinococcus multilocularis lamin 0.0114 0.0468 0.0468
Schistosoma mansoni DNA helicase recq1 0.0029 0.0048 0.011
Brugia malayi Pre-SET motif family protein 0.1117 0.5469 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0095 0.0496
Plasmodium falciparum LCCL domain-containing protein 0.0044 0.0118 0.3508
Brugia malayi orphan nuclear receptor NR2E1 0.0027 0.0037 0.0067
Echinococcus granulosus Excitatory amino acid transporter 0.0374 0.1768 0.1768
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0058 0.0189 0.0189
Brugia malayi von Willebrand factor type A domain containing protein 0.0038 0.0089 0.0162
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0058 0.0189 0.0298
Brugia malayi Pre-SET motif family protein 0.0161 0.0705 0.1289
Trypanosoma cruzi hypothetical protein, conserved 0.0308 0.1436 1
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0049 0.0147 0.1004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0061 0.0111
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2025 1 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0114 0.0738
Loa Loa (eye worm) hypothetical protein 0.0058 0.0189 0.0345
Onchocerca volvulus 0.0032 0.0061 0.0092
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0068 0.024 0.1531
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0053 0.0097
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0068 0.0125
Schistosoma mansoni intermediate filament proteins 0.0114 0.0468 0.1076
Loa Loa (eye worm) hypothetical protein 0.0058 0.0189 0.0345
Echinococcus multilocularis leukotriene A 4 hydrolase 0.024 0.11 0.11
Brugia malayi nuclear hormone receptor 0.0058 0.0189 0.0345
Loa Loa (eye worm) hypothetical protein 0.066 0.3194 0.584
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0049 0.0147 0.0148
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0111 0.0454 0.083
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0026 0.0047
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0048 0.0087
Echinococcus granulosus metabotropic glutamate receptor 5 0.0305 0.1422 0.1422
Loa Loa (eye worm) hypothetical protein 0.0078 0.0288 0.0527
Schistosoma mansoni thyroid hormone receptor 0.0324 0.1515 0.3486
Loa Loa (eye worm) excitatory amino acid transporter 0.0374 0.1768 0.3233
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0247 0.113 0.26
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0067
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.002 0.002
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.0111 0.0178
Mycobacterium leprae putative cytochrome p450 0.0049 0.0147 0.1004
Loa Loa (eye worm) TAR-binding protein 0.0191 0.0852 0.1559
Schistosoma mansoni ATP-binding cassette transporter 0.005 0.0148 0.0341
Plasmodium falciparum thrombospondin-related anonymous protein 0.0038 0.0089 0.2409
Brugia malayi steroid hormone receptor 0.0058 0.0189 0.0345
Onchocerca volvulus Bile acid receptor homolog 0.0058 0.0189 0.0298
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0027 0.0037 0.0037
Echinococcus granulosus tar DNA binding protein 0.0191 0.0852 0.0852
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0058 0.0189 0.0345
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0049 0.0147 0.0868
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0049 0.0147 0.0971
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0191 0.0852 0.1559
Loa Loa (eye worm) nuclear receptor NHR-67 0.0027 0.0037 0.0067
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0049 0.0147 0.0148
Brugia malayi Cytochrome P450 family protein 0.0068 0.024 0.044
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0024 0.0113
Schistosoma mansoni glutamate receptor NMDA 0.0082 0.0308 0.0708
Trichomonas vaginalis set domain proteins, putative 0.1271 0.6238 1
Plasmodium vivax hypothetical protein, conserved 0.0308 0.1436 1
Brugia malayi hypothetical protein 0.0053 0.0166 0.0304
Loa Loa (eye worm) inositol-1 0.0037 0.0086 0.0157
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0049 0.0147 0.1004
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.005 0.0151 0.0277
Brugia malayi nuclear hormone receptor family member odr-7 0.0027 0.0037 0.0067
Brugia malayi von Willebrand factor type A domain containing protein 0.0038 0.0089 0.0162
Onchocerca volvulus 0.0114 0.0468 0.0746
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0067 0.0066
Schistosoma mansoni steroid hormone receptor ad4bp 0.0058 0.0189 0.0435
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.0167 0.0167
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0095 0.0496
Brugia malayi Steroid receptor seven-up type 2 0.0058 0.0189 0.0345
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0048 0.0087
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0049 0.0147 0.1004
Schistosoma mansoni hypothetical protein 0.0892 0.4347 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0038 0.0089 0.0162
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0247 0.113 0.26
Loa Loa (eye worm) histone methyltransferase 0.0024 0.002 0.0036
Echinococcus multilocularis 0.0049 0.0147 0.0147
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0028 0.0039 0.0072
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0086 0.0086
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0061 0.0251
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0002 0.0002
Brugia malayi MH1 domain containing protein 0.0034 0.0068 0.0125
Loa Loa (eye worm) hypothetical protein 0.0044 0.0118 0.0216
Brugia malayi hypothetical protein 0.0112 0.046 0.0842
Loa Loa (eye worm) hypothetical protein 0.0038 0.0089 0.0162
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.046 0.046
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0161 0.0705 0.0705
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0071 0.0255 0.0466
Loa Loa (eye worm) RNA binding protein 0.0191 0.0852 0.1559
Loa Loa (eye worm) hypothetical protein 0.0161 0.0705 0.1289
Echinococcus granulosus RUN 0.0044 0.0118 0.0118
Trichomonas vaginalis rotamase, putative 0.0034 0.0069 0.0111
Brugia malayi MH2 domain containing protein 0.0034 0.0068 0.0125
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0169 0.0743 0.1358
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0308 0.1436 0.2626
Echinococcus multilocularis nmda type glutamate receptor 0.0032 0.0061 0.0061
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0095 0.0496
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0079 0.0297 0.0297
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0095 0.0496
Mycobacterium ulcerans hypothetical protein 0.0308 0.1436 1
Schistosoma mansoni hypothetical protein 0.0044 0.0118 0.0271
Loa Loa (eye worm) RGC/RGC protein kinase 0.0032 0.0061 0.0111
Loa Loa (eye worm) hepatopoietin HPO2 0.0068 0.024 0.044
Loa Loa (eye worm) hypothetical protein 0.0038 0.0089 0.0162
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0073 0.0134
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0097
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0256 0.1176 0.1176
Schistosoma mansoni inositol monophosphatase 0.0037 0.0086 0.0198
Leishmania major hypothetical protein, conserved 0.0068 0.024 0.1531
Loa Loa (eye worm) hypothetical protein 0.0305 0.1422 0.2599
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0068 0.024 0.8085
Brugia malayi beta-lactamase 0.0308 0.1436 0.2626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0026 0.0041
Echinococcus multilocularis tumor protein p63 0.0699 0.3386 0.3386
Echinococcus multilocularis beta LACTamase domain containing family member 0.0308 0.1436 0.1436
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0067
Schistosoma mansoni ap endonuclease 0.0078 0.0292 0.0671
Echinococcus granulosus FTZ F1 alpha 0.0058 0.0189 0.0189
Echinococcus multilocularis geminin 0.0892 0.4347 0.4347
Brugia malayi Guanylyl cyclase protein 23 0.0032 0.0061 0.0111
Mycobacterium leprae Probable lipase LipE 0.0308 0.1436 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0058 0.0189 0.0345
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0067
Trypanosoma cruzi cytochrome P450, putative 0.0068 0.024 0.1626
Schistosoma mansoni cellular tumor antigen P53 0.0102 0.0411 0.0946
Loa Loa (eye worm) RGC/RGC protein kinase 0.0032 0.0061 0.0111
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0273 0.1262 0.2903
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0166 0.0996
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0166 0.0729 0.0729
Loa Loa (eye worm) beta-lactamase 0.0308 0.1436 0.2626
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.024 0.11 0.253
Entamoeba histolytica hypothetical protein, conserved 0.0038 0.0089 0.1925
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0067 0.0446
Mycobacterium tuberculosis Conserved protein 0.0308 0.1436 0.1477
Echinococcus granulosus neutral amino acid transporter 0.0374 0.1768 0.1768
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0069 0.1507
Toxoplasma gondii Erv1 / Alr family protein 0.0068 0.024 0.1537
Brugia malayi photoreceptor-specific nuclear receptor 0.0058 0.0189 0.0345
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0154 0.0669 0.0669
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0266 0.1228 0.1228
Echinococcus granulosus GPCR family 2 0.0053 0.0167 0.0167
Echinococcus granulosus bloom syndrome protein 0.0042 0.0111 0.0111
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0086 0.0546
Echinococcus multilocularis pikachurin 0.005 0.0151 0.0151
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0061 0.026
Onchocerca volvulus 0.0038 0.0089 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0058 0.0189 0.0345
Brugia malayi Excitatory amino acid transporter 0.0374 0.1768 0.3233
Loa Loa (eye worm) hypothetical protein 0.0032 0.0061 0.0111
Entamoeba histolytica hypothetical protein 0.0032 0.0061 0.1314
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0061 0.037
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0039 0.0095 0.0148
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0445 0.2122 0.4881
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0082 0.0308 0.0308
Brugia malayi RNA recognition motif domain containing protein 0.0191 0.0852 0.1559
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0058 0.0189 0.0189
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.0509 0.0509
Mycobacterium tuberculosis Probable lipase LipE 0.0308 0.1436 0.1477
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0055 0.0175 0.0175
Schistosoma mansoni glutamate receptor kainate 0.005 0.0148 0.0341
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0029 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0067
Schistosoma mansoni smad1 5 8 and 0.0034 0.0068 0.0157
Echinococcus granulosus leukotriene A 4 hydrolase 0.024 0.11 0.11
Schistosoma mansoni lamin 0.0114 0.0468 0.1076
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0095 0.0612
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0234 0.1585
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0049 0.0147 0.0148
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0616 0.4192
Echinococcus granulosus dnaJ subfamily B 0.0823 0.4003 0.4003
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0086 0.0086
Echinococcus multilocularis Polycystic kidney disease protein 0.0044 0.0118 0.0118
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.002 0.002
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.0509 0.0509
Brugia malayi Cytochrome P450 family protein 0.0049 0.0147 0.0268
Brugia malayi Receptor family ligand binding region containing protein 0.0032 0.0061 0.0111
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0049 0.0147 0.0148
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0097
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0069 0.032
Brugia malayi von Willebrand factor type A domain containing protein 0.0038 0.0089 0.0162
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0049 0.0147 0.1004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0058 0.0189 0.0345
Schistosoma mansoni blooms syndrome DNA helicase 0.0027 0.0036 0.0084
Mycobacterium leprae Conserved hypothetical protein 0.0049 0.0147 0.1004
Loa Loa (eye worm) CUTiclin family member 0.0038 0.0089 0.0162
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0095 0.2074
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.1069 0.1955
Brugia malayi hypothetical protein 0.0027 0.0037 0.0067
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0078 0.0292 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0078 0.0292 0.1894
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0038 0.0089 0.0089
Loa Loa (eye worm) transcription factor SMAD2 0.0493 0.2357 0.431
Schistosoma mansoni Smad4 0.0034 0.0068 0.0157
Brugia malayi beta-lactamase family protein 0.0308 0.1436 0.2626
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0067
Brugia malayi MH2 domain containing protein 0.0493 0.2357 0.431
Brugia malayi Calcitonin receptor-like protein seb-1 0.0169 0.0743 0.1358
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0095 0.0646
Brugia malayi Zona pellucida-like domain containing protein 0.0038 0.0089 0.0162
Loa Loa (eye worm) hypothetical protein 0.0308 0.1436 0.2626
Echinococcus granulosus tumor protein p63 0.0699 0.3386 0.3386
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.0288 0.1869
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0308 0.1436 0.2626
Echinococcus multilocularis neurogenic locus notch protein 0.005 0.0151 0.0151
Trypanosoma brucei hypothetical protein, conserved 0.0308 0.1436 1
Toxoplasma gondii exonuclease III APE 0.0078 0.0292 0.1899
Echinococcus granulosus excitatory amino acid transporter 2 0.0374 0.1768 0.1768
Brugia malayi ecdysteroid receptor 0.0058 0.0189 0.0345
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0049 0.0147 0.0148
Loa Loa (eye worm) hypothetical protein 0.0058 0.0189 0.0345
Schistosoma mansoni protein kinase 0.0032 0.0061 0.0139
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0095 0.0612
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0037 0.0067
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0068 0.024 0.1627
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0166 0.1005
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0049 0.0147 0.1004
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0189 0.0346
Loa Loa (eye worm) hypothetical protein 0.0039 0.0095 0.0175
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0058 0.0189 0.0189
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0049 0.0147 0.1004
Brugia malayi Glutamate receptor 1 precursor 0.005 0.0148 0.0271
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0027 0.0037 0.0085
Echinococcus multilocularis lamin dm0 0.0114 0.0468 0.0468
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.152 0.7479 1
Trypanosoma brucei unspecified product 0.0027 0.0035 0.0068
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.0098 0.2761
Onchocerca volvulus 0.1271 0.6238 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0256 0.1176 0.8182
Schistosoma mansoni smad1 5 8 and 0.0034 0.0068 0.0157
Onchocerca volvulus 0.0038 0.0089 0.0138
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0053 0.0166 0.0304
Schistosoma mansoni tyrosine kinase 0.0032 0.0061 0.0139
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0058 0.0189 0.0189
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0234 0.0429
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.1412 0.983
Echinococcus multilocularis excitatory amino acid transporter 2 0.0374 0.1768 0.1768
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0055 0.0175 0.0175
Entamoeba histolytica elongation factor-2 kinase, putative 0.0038 0.0089 0.1925
Echinococcus granulosus tissue type plasminogen activator 0.0025 0.0024 0.0024
Echinococcus multilocularis nuclear receptor nhr 48 0.0027 0.0037 0.0037
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0049 0.0147 0.0148
Schistosoma mansoni smad1 5 8 and 0.0034 0.0068 0.0157
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0053 0.0167 0.0167
Echinococcus granulosus expressed protein 0.0386 0.1827 0.1827
Loa Loa (eye worm) hypothetical protein 0.0038 0.0089 0.0162
Mycobacterium tuberculosis Probable hydrolase 0.0308 0.1436 0.1477
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0234 0.0234
Echinococcus multilocularis GPCR, family 2 0.0053 0.0167 0.0167
Schistosoma mansoni hypothetical protein 0.0892 0.4347 1
Schistosoma mansoni DNA helicase recq5 0.0029 0.0048 0.011
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0068 0.0068
Brugia malayi follicle stimulating hormone receptor 0.0234 0.1069 0.1955
Loa Loa (eye worm) cytochrome P450 0.0049 0.0147 0.0268
Brugia malayi hypothetical protein 0.0032 0.0061 0.0111
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0049 0.0147 0.1004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0095 0.0612
Loa Loa (eye worm) glutamate receptor 1 0.005 0.0148 0.0271
Brugia malayi Glutamate receptor 2 precursor 0.005 0.0148 0.0271
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0058 0.0189 0.0435
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0234 0.1481
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0097
Brugia malayi laminin-like protein K08C7.3 precursor 0.005 0.0151 0.0277
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0058 0.0189 0.0345
Brugia malayi Kringle domain containing protein 0.0025 0.0024 0.0044
Echinococcus granulosus neurogenic locus notch protein 0.005 0.0151 0.0151
Schistosoma mansoni inositol monophosphatase 0.0037 0.0086 0.0198
Onchocerca volvulus 0.0308 0.1436 0.2299
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0143 0.0612 0.0612
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0032 0.0061 0.0061
Loa Loa (eye worm) cytochrome P450 family protein 0.0068 0.024 0.044
Brugia malayi intermediate filament protein 0.0114 0.0468 0.0855
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0058 0.0189 0.0189
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0308 0.1436 0.1477
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0095 0.0095
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0037 0.0037
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0058 0.0189 0.0345
Schistosoma mansoni polycystin 1-related 0.0044 0.0118 0.0271
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.0167 0.0306
Mycobacterium ulcerans esterase/lipase LipP 0.0308 0.1436 1
Brugia malayi Doublecortin family protein 0.0044 0.0118 0.0216
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0049 0.0147 0.0148
Schistosoma mansoni cytochrome P450 0.0049 0.0147 0.0338
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.005 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0029 0.0048 0.0087
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.0118 0.0118
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0143 0.0612 0.0612
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1653 0.8143 0.8143
Echinococcus multilocularis expressed protein 0.0386 0.1827 0.1827
Giardia lamblia DINP protein human, muc B family 0.0039 0.0095 0.1955
Onchocerca volvulus 0.0032 0.0061 0.0092
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.0292 1
Loa Loa (eye worm) nuclear hormone receptor 0.0027 0.0037 0.0067
Echinococcus multilocularis neutral amino acid transporter A 0.0374 0.1768 0.1768
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0374 0.1768 0.1768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.0292 0.1894
Echinococcus multilocularis excitatory amino acid transporter 3 0.0374 0.1768 0.1768
Schistosoma mansoni ap endonuclease 0.0078 0.0292 0.0671
Loa Loa (eye worm) cytochrome P450 family protein 0.0068 0.024 0.044
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0114 0.0468 0.0855
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0247 0.113 0.113
Echinococcus granulosus GPCR family 3 C terminal 0.0039 0.0095 0.0095
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0029 0.0048 0.0048
Loa Loa (eye worm) CYP4Cod1 0.0068 0.024 0.044
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0049 0.0147 0.1004
Entamoeba histolytica hypothetical protein 0.0025 0.0026 0.0554
Brugia malayi MH1 domain containing protein 0.0034 0.0068 0.0125
Trichomonas vaginalis penicillin-binding protein, putative 0.0308 0.1436 0.2303
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0095 0.0095
Schistosoma mansoni rotamase 0.0035 0.0073 0.0169
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0303 0.1412 0.9828
Echinococcus multilocularis Excitatory amino acid transporter 0.0374 0.1768 0.1768
Echinococcus multilocularis Excitatory amino acid transporter 0.0374 0.1768 0.1768
Echinococcus granulosus collagen alpha 1VII chain 0.0038 0.0089 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0161 0.0705 0.1622
Echinococcus granulosus atrial natriuretic peptide receptor 0.0032 0.0061 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0058 0.0189 0.0345
Echinococcus multilocularis thyroid hormone receptor alpha 0.0324 0.1515 0.1515
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0067
Echinococcus multilocularis expressed protein 0.0035 0.0073 0.0073
Brugia malayi RNA binding protein 0.0191 0.0852 0.1559
Schistosoma mansoni hypothetical protein 0.0038 0.0089 0.0204
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0049 0.0147 0.0148
Entamoeba histolytica hypothetical protein, conserved 0.0038 0.0089 0.1925
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0095 0.0175
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0086 0.0438
Brugia malayi hypothetical protein 0.0253 0.1164 0.2129
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0049 0.0147 0.1004
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0166 0.1011
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0161 0.0705 0.4825
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0143 0.0612 0.0612
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0038 0.0089 0.0456
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0037 0.0037
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0038 0.0089 0.0456
Leishmania major DNA polymerase eta, putative 0.0039 0.0095 0.0505
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0049 0.0147 0.0148
Mycobacterium ulcerans endonuclease IV 0.0078 0.0288 0.199
Brugia malayi nuclear hormone receptor 0.0027 0.0037 0.0067
Trypanosoma cruzi hypothetical protein, conserved 0.0308 0.1436 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0049 0.0147 0.1004
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0095 0.0496
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0095 0.0153
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0086 0.0445
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0169 0.0743 0.1358
Treponema pallidum exodeoxyribonuclease (exoA) 0.0078 0.0292 0.0275
Schistosoma mansoni loxhd1 0.0044 0.0118 0.0271
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0234 0.0429
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1117 0.5469 1
Brugia malayi nuclear receptor NHR-88 0.0058 0.0189 0.0345
Toxoplasma gondii microneme protein MIC2 0.0038 0.0089 0.0463
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0058 0.0189 0.0345
Entamoeba histolytica recQ family helicase, putative 0.0032 0.0061 0.1323
Echinococcus granulosus Polycystic kidney disease protein 0.0044 0.0118 0.0118
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0308 0.1436 0.1477
Echinococcus granulosus lamin dm0 0.0114 0.0468 0.0468
Onchocerca volvulus 0.0044 0.0118 0.0185
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0037 0.0037
Loa Loa (eye worm) CUTiclin-Like family member 0.0038 0.0089 0.0162
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0058 0.0189 0.0435
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0058 0.0189 0.0345
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0086 0.0581
Loa Loa (eye worm) hypothetical protein 0.0038 0.0089 0.0162
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0097
Echinococcus granulosus nmda type glutamate receptor 0.0032 0.0061 0.0061
Schistosoma mansoni lipoxygenase 0.0044 0.0118 0.0271
Treponema pallidum glutamate/aspartate transporter 0.0166 0.0729 0.0866
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0308 0.1436 0.1477
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0166 0.5306
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0049 0.0147 0.1004
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0616 0.4187
Loa Loa (eye worm) hypothetical protein 0.0058 0.0189 0.0345
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0058 0.0189 0.0345
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0058 0.0189 0.0345
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0067
Loa Loa (eye worm) hypothetical protein 0.005 0.0151 0.0277
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0049 0.0147 0.1004
Echinococcus multilocularis microtubule associated protein 2 0.072 0.3491 0.3491
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0234 0.0234
Brugia malayi von Willebrand factor type A domain containing protein 0.0038 0.0089 0.0162
Schistosoma mansoni nuclear receptor nhr-48 0.0027 0.0037 0.0085
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0095 0.0496
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0161 0.0705 0.1622
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0161 0.0705 0.1622
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0027 0.0037 0.0037
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0026 0.0059
Loa Loa (eye worm) hypothetical protein 0.005 0.0151 0.0277
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0049 0.0147 0.0148
Entamoeba histolytica hypothetical protein 0.0112 0.046 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0049 0.0147 0.0148
Schistosoma mansoni DNA polymerase eta 0.0039 0.0095 0.022
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0058 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0032 0.0061 0.0111
Loa Loa (eye worm) hypothetical protein 0.0032 0.0061 0.0111
Brugia malayi Smad1 0.0034 0.0068 0.0125
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0166 0.0729 0.1676
Schistosoma mansoni hypothetical protein 0.0025 0.0024 0.0056
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0037 0.0037
Schistosoma mansoni rab6-interacting 0.0044 0.0118 0.0271
Schistosoma mansoni hypothetical protein 0.0049 0.0147 0.0338
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0053 0.0167 0.0167
Plasmodium vivax SET domain protein, putative 0.0161 0.0705 0.4821
Onchocerca volvulus 0.0027 0.0037 0.0055
Echinococcus granulosus microtubule associated protein 2 0.072 0.3491 0.3491
Echinococcus granulosus ecdysone induced protein 78C 0.0058 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0169 0.0743 0.1358
Schistosoma mansoni cell polarity protein 0.005 0.0151 0.0348
Loa Loa (eye worm) hypothetical protein 0.0032 0.0061 0.0111
Trichomonas vaginalis penicillin-binding protein, putative 0.0308 0.1436 0.2303
Loa Loa (eye worm) hypothetical protein 0.0038 0.0089 0.0162
Trypanosoma brucei unspecified product 0.0039 0.0095 0.0496
Brugia malayi hypothetical protein 0.0111 0.0452 0.0827
Entamoeba histolytica hypothetical protein 0.0112 0.046 1
Echinococcus multilocularis glutamate receptor 2 0.0063 0.0216 0.0216
Brugia malayi latrophilin 2 splice variant baaae 0.0115 0.0477 0.0871
Schistosoma mansoni glutamate receptor kainate 0.0111 0.0453 0.1041
Brugia malayi EGF-like domain containing protein 0.005 0.0151 0.0277
Mycobacterium tuberculosis Probable esterase LipL 0.0308 0.1436 0.1477
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0247 0.113 0.113
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0026 0.0026
Leishmania major hypothetical protein, conserved 0.0308 0.1436 1
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0026 0.0026
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0078 0.0292 0.6333
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.003 0.0053 0.0053
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0027 0.0037 0.0067
Onchocerca volvulus 0.0038 0.0089 0.0138
Toxoplasma gondii Erv1 / Alr family protein 0.0068 0.024 0.1537
Mycobacterium ulcerans hypothetical protein 0.016 0.0697 0.4842
Loa Loa (eye worm) hypothetical protein 0.0038 0.0089 0.0162
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0058 0.0189 0.0189
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0049 0.0147 0.0148
Leishmania major cytochrome p450-like protein 0.0049 0.0147 0.0868
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0095 0.022
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0049 0.0147 0.1004
Echinococcus multilocularis mixed lineage leukemia protein mll 0.002 0.0002 0.0002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0247 0.113 0.2067
Loa Loa (eye worm) hypothetical protein 0.0071 0.0255 0.0466
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0067
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0078 0.0292 0.0297
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0038 0.0089 0.0162
Echinococcus multilocularis slit 2 protein 0.005 0.0151 0.0151
Trichomonas vaginalis D-aminoacylase, putative 0.0308 0.1436 0.2303
Brugia malayi von Willebrand factor type A domain containing protein 0.0038 0.0089 0.0162
Echinococcus multilocularis RUN 0.0044 0.0118 0.0118
Echinococcus granulosus cpg binding protein 0.0061 0.0205 0.0205
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0069 0.0429
Echinococcus multilocularis neutral amino acid transporter A 0.0374 0.1768 0.1768
Brugia malayi nuclear receptor NHR-67 0.0027 0.0037 0.0067
Echinococcus granulosus dna polymerase kappa 0.0039 0.0095 0.0095
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.0115 0.0477 0.1096
Echinococcus multilocularis ecdysone induced protein 78C 0.0058 0.0189 0.0189
Loa Loa (eye worm) TK/ROR protein kinase 0.0025 0.0024 0.0044
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0095 0.0496
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0069 0.0311
Schistosoma mansoni rab6-interacting 0.0044 0.0118 0.0271
Schistosoma mansoni aldehyde dehydrogenase 0.0256 0.1176 0.2705
Brugia malayi Protein kinase domain containing protein 0.0025 0.0024 0.0044
Schistosoma mansoni RAR-like nuclear receptor 0.0058 0.0189 0.0435
Mycobacterium ulcerans aldehyde dehydrogenase 0.0256 0.1176 0.8182
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0161 0.0705 0.0705
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0095 0.0496
Schistosoma mansoni tar DNA-binding protein 0.0191 0.0852 0.1961
Schistosoma mansoni lamin 0.0114 0.0468 0.1076
Echinococcus granulosus Excitatory amino acid transporter 0.0374 0.1768 0.1768
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0143 0.0612 0.0612
Echinococcus multilocularis dna polymerase eta 0.0039 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0102 0.0411 0.0752
Brugia malayi Zona pellucida-like domain containing protein 0.0038 0.0089 0.0162
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0247 0.113 0.2067
Echinococcus granulosus smad 0.0034 0.0068 0.0068
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0049 0.0147 0.0148
Entamoeba histolytica hypothetical protein 0.0112 0.046 1
Schistosoma mansoni aldehyde dehydrogenase 0.0256 0.1176 0.2705
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0082 0.0308 0.0308
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0049 0.0147 0.1004
Loa Loa (eye worm) hypothetical protein 0.0308 0.1436 0.2626
Schistosoma mansoni tyrosine kinase 0.0032 0.0061 0.0139
Trichomonas vaginalis D-aminoacylase, putative 0.0308 0.1436 0.2303
Loa Loa (eye worm) hypothetical protein 0.0038 0.0089 0.0162
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0005
Schistosoma mansoni hypothetical protein 0.0053 0.0167 0.0385
Toxoplasma gondii kringle domain-containing protein 0.0025 0.0024 0.0007
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0068 0.0157
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0089 0.0456
Loa Loa (eye worm) hypothetical protein 0.0038 0.0089 0.0162
Loa Loa (eye worm) hypothetical protein 0.0058 0.0189 0.0345
Brugia malayi Cytochrome P450 family protein 0.0068 0.024 0.044
Loa Loa (eye worm) hypothetical protein 0.0058 0.0189 0.0345
Loa Loa (eye worm) hypothetical protein 0.0058 0.0189 0.0345
Loa Loa (eye worm) Smad1 0.0034 0.0068 0.0125
Loa Loa (eye worm) hypothetical protein 0.0038 0.0089 0.0162
Brugia malayi nuclear hormone receptor family member nhr-6 0.0027 0.0037 0.0067
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.003 0.0053 0.0097
Schistosoma mansoni cpg binding protein 0.0058 0.0189 0.0435
Schistosoma mansoni serine-rich repeat protein 0.0476 0.2273 0.5229
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0086 0.0138
Trypanosoma brucei unspecified product 0.0027 0.0035 0.0068
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0048 0.0174
Schistosoma mansoni tar DNA-binding protein 0.0191 0.0852 0.1961
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0095 0.0612
Echinococcus granulosus metabotropic glutamate receptor 2 0.0211 0.0951 0.0951
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0166 0.1106
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0078 0.0292 0.2014
Brugia malayi hypothetical protein 0.0044 0.0118 0.0216
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0095 0.0496
Loa Loa (eye worm) hypothetical protein 0.0053 0.0164 0.03
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0068 0.0125
Echinococcus granulosus glutamate receptor 2 0.0063 0.0216 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0058 0.0189 0.0345
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0256 0.1176 0.1176
Loa Loa (eye worm) DR-78 0.0027 0.0037 0.0067
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0086 0.0138
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0038 0.0089 0.2409
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0067
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0616 0.4258
Mycobacterium tuberculosis Conserved protein 0.0308 0.1436 0.1477
Schistosoma mansoni hypothetical protein 0.0024 0.002 0.0046
Treponema pallidum glutamate transporter 0.0166 0.0729 0.0866
Echinococcus multilocularis cpg binding protein 0.0061 0.0205 0.0205
Trichomonas vaginalis DNA helicase recq1, putative 0.0042 0.0111 0.0178
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0079 0.0297 0.0297
Leishmania major mitochondrial DNA polymerase beta 0.0303 0.1412 0.9829
Schistosoma mansoni nuclear hormone receptor 0.0058 0.0189 0.0435
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0039 0.0095 0.0174
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0095 0.0646
Schistosoma mansoni cpg binding protein 0.0061 0.0205 0.0473
Onchocerca volvulus 0.0161 0.0705 0.1126
Loa Loa (eye worm) hypothetical protein 0.0032 0.0061 0.0111
Schistosoma mansoni tar DNA-binding protein 0.0191 0.0852 0.1961
Brugia malayi MH2 domain containing protein 0.0034 0.0068 0.0125
Brugia malayi TAR-binding protein 0.0191 0.0852 0.1559
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0086 0.0546
Schistosoma mansoni laminin gamma-3 chain 0.005 0.0151 0.0348
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.0167 0.0167
Echinococcus granulosus mixed lineage leukemia protein mll 0.002 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0408 0.1934 0.3537
Loa Loa (eye worm) hypothetical protein 0.0038 0.0089 0.0162
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0095 0.0496
Trypanosoma brucei cytochrome P450, putative 0.0068 0.024 0.1523
Loa Loa (eye worm) hypothetical protein 0.0112 0.0457 0.0836
Loa Loa (eye worm) hypothetical protein 0.0053 0.0167 0.0306
Schistosoma mansoni metabotropic glutamate receptor 0.0126 0.0531 0.1222
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0234 0.1489
Brugia malayi Receptor family ligand binding region containing protein 0.0071 0.0255 0.0466
Brugia malayi hypothetical protein 0.0038 0.0089 0.0162
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0037 0.0067
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0095 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0058 0.0189 0.0345
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0067
Brugia malayi hypothetical protein 0.0027 0.0037 0.0067
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0032 0.0061 0.0111
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0049 0.0147 0.0971
Loa Loa (eye worm) glutamate receptor 2 0.005 0.0148 0.0271
Onchocerca volvulus Protein ultraspiracle homolog 0.0058 0.0189 0.0298
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.0167 0.0306
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0095 0.0095
Brugia malayi Latrophilin receptor protein 2 0.0053 0.0167 0.0306
Loa Loa (eye worm) steroid hormone receptor 0.0058 0.0189 0.0345
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0111 0.0454 0.1044
Echinococcus granulosus pikachurin 0.005 0.0151 0.0151
Echinococcus granulosus histone lysine methyltransferase setb 0.0161 0.0705 0.0705
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0143 0.0612 0.0612
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0234 0.1585
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0166 0.1106
Schistosoma mansoni tar DNA-binding protein 0.0191 0.0852 0.1961
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0111 0.0454 0.1044
Leishmania major extracellular receptor, putative 0.0032 0.0061 0.0257
Loa Loa (eye worm) hypothetical protein 0.0055 0.0175 0.0319
Echinococcus multilocularis glutamate receptor 2 0.0082 0.0308 0.0308
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.1412 0.983
Brugia malayi Intermediate filament tail domain containing protein 0.0114 0.0468 0.0855
Loa Loa (eye worm) hypothetical protein 0.0308 0.1436 0.2626
Echinococcus multilocularis GPCR, family 3, C terminal 0.0039 0.0095 0.0095
Echinococcus granulosus neutral amino acid transporter A 0.0374 0.1768 0.1768
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0256 0.1176 0.8155
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.003 0.0053 0.0122
Mycobacterium ulcerans aldehyde dehydrogenase 0.0256 0.1176 0.8182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0058 0.0189 0.0345
Echinococcus multilocularis neutral amino acid transporter A 0.0374 0.1768 0.1768
Chlamydia trachomatis glutamate symporter 0.0374 0.1768 1
Schistosoma mansoni glutamate receptor NMDA 0.005 0.0148 0.0341
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.0292 0.0468
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0032 0.0061 0.0111
Loa Loa (eye worm) hypothetical protein 0.0038 0.0089 0.0162
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0086 0.1871
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0038 0.0089 0.2409
Mycobacterium leprae conserved hypothetical protein 0.0308 0.1436 1
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0374 0.1768 0.2831
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0068 0.024 0.1627
Echinococcus granulosus slit 2 protein 0.005 0.0151 0.0151
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0114 0.0738
Schistosoma mansoni glutamate receptor kainate 0.0111 0.0453 0.1041
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0027 0.0037 0.0067
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0067
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0078 0.0288 0.0527
Toxoplasma gondii endonuclease IV APN 0.0078 0.0288 0.1875
Entamoeba histolytica hypothetical protein 0.0112 0.046 1
Trichomonas vaginalis D-aminoacylase, putative 0.0308 0.1436 0.2303
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0049 0.0147 0.0148
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0068 0.024 0.1627
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0058 0.0189 0.0189
Onchocerca volvulus 0.0058 0.0189 0.0298
Echinococcus multilocularis smad 0.0034 0.0068 0.0068
Schistosoma mansoni retinoic acid receptor RXR 0.0058 0.0189 0.0435
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0027 0.0037 0.0085
Brugia malayi von Willebrand factor type A domain containing protein 0.0038 0.0089 0.0162
Schistosoma mansoni glutamate receptor AMPA 0.005 0.0148 0.0341
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0374 0.1768 0.1768
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0218 0.0986 0.1802
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0053 0.0122
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0078 0.0292 0.1886
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0247 0.113 0.113
Toxoplasma gondii hypothetical protein 0.0049 0.0145 0.086
Loa Loa (eye worm) hypothetical protein 0.005 0.0151 0.0277
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0374 0.1768 0.4067
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0068 0.024 0.1523
Leishmania major hypothetical protein, conserved 0.0053 0.0166 0.1005
Brugia malayi nuclear receptor NHR-88 0.0027 0.0037 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0035 0.0068
Schistosoma mansoni hypothetical protein 0.0039 0.0095 0.0219
Loa Loa (eye worm) leukotriene A4 hydrolase 0.024 0.11 0.2011
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0073 0.0118
Echinococcus multilocularis NMDA receptor 0.0079 0.0297 0.0297
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0002 0.0004
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.0292 0.0468
Onchocerca volvulus 0.0038 0.0089 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0058 0.0189 0.0345
Schistosoma mansoni hypothetical protein 0.0038 0.0089 0.0204
Mycobacterium tuberculosis Probable lipase LipD 0.0308 0.1436 0.1477
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0476 0.3204
Echinococcus multilocularis tyrosine kinase 0.0032 0.0061 0.0061
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0049 0.0147 0.0148
Loa Loa (eye worm) cytochrome P450 family protein 0.0192 0.086 0.1573
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0111 0.0454 0.0454
Brugia malayi beta-lactamase family protein 0.0308 0.1436 0.2626
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0037 0.0085
Echinococcus granulosus expressed protein 0.0035 0.0073 0.0073
Onchocerca volvulus 0.0038 0.0089 0.0138
Loa Loa (eye worm) RecQ helicase 0.0042 0.0111 0.0203
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.016 0.1064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0247 0.113 0.113
Schistosoma mansoni nuclear receptor 0.0027 0.0037 0.0085
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.002 0.002
Mycobacterium tuberculosis Conserved protein 0.0308 0.1436 0.1477
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.005 0.0151 0.0348
Trichomonas vaginalis DNA helicase recq, putative 0.0032 0.0061 0.0098
Loa Loa (eye worm) RGC/RGC protein kinase 0.0032 0.0061 0.0111
Loa Loa (eye worm) MH2 domain-containing protein 0.0493 0.2357 0.431
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0037 0.0055
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0111 0.0454 0.1044
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0078 0.0292 0.0292
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0073 0.0134
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0067
Onchocerca volvulus Poor gastrulation protein homolog 0.0039 0.0095 0.0148
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0037 0.0055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0247 0.113 0.26
Brugia malayi metabotropic glutamate receptor type 2 0.0126 0.0531 0.0972
Echinococcus granulosus glutamate NMDA receptor subunit 0.005 0.0148 0.0148
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0128 0.0541 0.1245
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0095 0.0153
Loa Loa (eye worm) hypothetical protein 0.0308 0.1436 0.2626
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0095 0.0175
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0027 0.0037 0.0037
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0049 0.0147 0.1004
Echinococcus granulosus dna polymerase eta 0.0039 0.0095 0.0095
Schistosoma mansoni microtubule-associated protein tau 0.072 0.3491 0.803
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0038 0.0089 0.0456
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0111 0.0454 0.083
Loa Loa (eye worm) doublecortin family protein 0.0044 0.0118 0.0216
Trypanosoma cruzi cytochrome P450, putative 0.0068 0.024 0.1626
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0095 0.0496
Trichomonas vaginalis rotamase, putative 0.0035 0.0073 0.0118
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0048 0.0174
Echinococcus granulosus excitatory amino acid transporter 2 0.0374 0.1768 0.1768
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0058 0.0189 0.0189
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0029 0.0048 0.0048
Leishmania major cytochrome p450-like protein 0.0068 0.024 0.1531
Echinococcus multilocularis FTZ F1 alpha 0.0058 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0038 0.0089 0.0162
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0058 0.0189 0.0435
Echinococcus granulosus glutamate receptor 2 0.0082 0.0308 0.0308
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0166 0.0729 0.1676
Echinococcus multilocularis receptor type guanylyl cyclase 0.0032 0.0061 0.0061
Brugia malayi Cytochrome P450 family protein 0.0192 0.086 0.1573
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0166 0.5306
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0049 0.0147 0.1004
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0058 0.0189 0.0189
Loa Loa (eye worm) intermediate filament protein 0.0114 0.0468 0.0855
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0058 0.0189 0.0345
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0086 0.043
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0068 0.024 0.1657
Loa Loa (eye worm) hypothetical protein 0.0039 0.0095 0.0174
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0053 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0058 0.0189 0.0345
Brugia malayi Metabotropic glutamate receptor precursor. 0.0249 0.1145 0.2094
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0061 0.0205 0.0374
Echinococcus granulosus voltage dependent calcium channel subunit 0.0921 0.4494 0.4494
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0068 0.0068
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0095 0.022
Brugia malayi conserved hypotetical protein 0.0027 0.0037 0.0067
Schistosoma mansoni hypothetical protein 0.0053 0.0167 0.0385
Loa Loa (eye worm) hypothetical protein 0.0044 0.0118 0.0216
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0058 0.0189 0.0435
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0037 0.0037
Echinococcus granulosus Smad4 0.0034 0.0068 0.0068
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0078 0.0292 0.0533
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0211 0.0951 0.0951
Onchocerca volvulus 0.0038 0.0089 0.0138
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.003 0.0053 0.0053
Echinococcus multilocularis glutamate receptor 2 0.005 0.0148 0.0148
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0026 0.0016
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0114 0.0624

Activities

Activity type Activity value Assay description Source Reference
PFA (functional) 0 mg kg-1 Oral antiallergy activity in the passive foot anaphylaxis (PFA) model of rat, at a dose of 10 (mg/kg); not significantly different from negative control group ChEMBL. 2562852

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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