Detailed information for compound 24043

Basic information

Technical information
  • TDR Targets ID: 24043
  • Name: 3-[4-(2-methoxyphenyl)piperazin-1-yl]-1,2,3,4 ,4a,5,6,7,8,8a-decahydronaphthalen-2-ol
  • MW: 344.491 | Formula: C21H32N2O2
  • H donors: 1 H acceptors: 1 LogP: 4.22 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1N1CCN(CC1)C1CC2CCCCC2CC1O
  • InChi: 1S/C21H32N2O2/c1-25-21-9-5-4-8-18(21)22-10-12-23(13-11-22)19-14-16-6-2-3-7-17(16)15-20(19)24/h4-5,8-9,16-17,19-20,24H,2-3,6-7,10-15H2,1H3
  • InChiKey: AQASAEVOTVAACQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[4-(2-methoxyphenyl)piperazin-1-yl]decalin-2-ol
  • 3-[4-(2-methoxyphenyl)-1-piperazinyl]-2-decalinol
  • 3-[4-(2-methoxyphenyl)piperazino]decalin-2-ol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 18 (vesicular acetylcholine transporter), member 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus vesicular acetylcholine transporter Get druggable targets OG5_133283 All targets in OG5_133283
Schistosoma japonicum ko:K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular, putative Get druggable targets OG5_133283 All targets in OG5_133283
Brugia malayi vesicular acetylcholine transporter unc-17 Get druggable targets OG5_133283 All targets in OG5_133283
Echinococcus multilocularis vesicular acetylcholine transporter Get druggable targets OG5_133283 All targets in OG5_133283
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 Get druggable targets OG5_133283 All targets in OG5_133283
Schistosoma mansoni vesicular acetylcholine transporter Get druggable targets OG5_133283 All targets in OG5_133283
Onchocerca volvulus Vesicular acetylcholine transporter homolog Get druggable targets OG5_133283 All targets in OG5_133283
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Abnormal catecholamine distribution protein 1 solute carrier family 18 (vesicular acetylcholine transporter), member 3 532 aa 504 aa 34.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni z-protein (S1r protein) 0.006 0.0185 0.0427
Onchocerca volvulus 0.0037 0.01 0.0503
Loa Loa (eye worm) hypothetical protein 0.0045 0.0131 0.0641
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.006 0.0185 0.0182
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.0106 0.0103
Loa Loa (eye worm) hypothetical protein 0.0049 0.0146 0.0716
Brugia malayi hypothetical protein 0.0105 0.0358 0.1794
Trichomonas vaginalis rotamase, putative 0.0036 0.0094 0.0473
Loa Loa (eye worm) hypothetical protein 0.0045 0.0131 0.0641
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0091 0.2256
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0106 0.0518
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0312 0.114 0.1138
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0015 0.0017 0.0039
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.006 0.0185 0.0917
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0185 0.0427
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0037 0.0085
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0037 0.01 0.0488
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0165
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0091 0.226
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0131 0.0644
Toxoplasma gondii subtilisin SUB12 0.0014 0.0013 0.0111
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0177
Toxoplasma gondii hypothetical protein 0.0014 0.0013 0.0111
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.006 0.0185 0.0917
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0106 0.0518
Toxoplasma gondii microneme protein, putative 0.0014 0.0013 0.0111
Onchocerca volvulus 0.0045 0.0131 0.0666
Treponema pallidum hypothetical protein 0.0049 0.0146 0.0188
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.0042 0.2613
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.0106 0.0518
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0017 0.0024 0.0104
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0017 0.0024 0.0593
Echinococcus granulosus nAChR subunit 0.002 0.0035 0.0032
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0403 1
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0042 0.0039
Loa Loa (eye worm) aldehyde dehydrogenase 0.0017 0.0024 0.0102
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.0106 0.0103
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0123
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0039 0.0036
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.011 0.2733
Onchocerca volvulus 0.0022 0.0042 0.0195
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.0106 0.0244
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.0106 0.0516
Plasmodium falciparum amino acid transporter, putative 0.0045 0.0131 0.8941
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0028 0.0025
Brugia malayi regulator of G-protein signaling rgs-7 0.006 0.0185 0.0919
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0079 0.0392
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0037 0.01 0.023
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.0106 0.0518
Loa Loa (eye worm) hypothetical protein 0.0049 0.0146 0.0716
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.006 0.0185 0.0427
Brugia malayi Cytochrome P450 family protein 0.0026 0.0057 0.0271
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0005 0.0002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0312 0.114 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0157
Toxoplasma gondii microneme protein MIC17B 0.0014 0.0013 0.0111
Onchocerca volvulus 0.0017 0.0024 0.01
Brugia malayi hypothetical protein 0.0017 0.0024 0.0104
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0102
Brugia malayi PXA domain containing protein 0.006 0.0185 0.0919
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0403 1
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0024 0.0056
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.0106 0.0244
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.0045 0.0131 0.0641
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0005 0.0002
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.0106 0.0103
Brugia malayi Intermediate filament tail domain containing protein 0.0085 0.028 0.1397
Schistosoma mansoni DNA helicase recq5 0.0021 0.0039 0.0091
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0039 0.0971
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0017 0.0024 0.0593
Echinococcus multilocularis lamin 0.0085 0.028 0.0277
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0017 0.0024 0.0021
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0156 0.0772
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0012 0.0005 0.0124
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.0403 0.3397
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.0403 0.04
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0299 0.1092 0.109
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0094 0.0459
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0039 0.0181
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0039 0.0036
Echinococcus granulosus Excitatory amino acid transporter 0.0127 0.044 0.0437
Onchocerca volvulus 0.0085 0.028 0.1458
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.0106 0.0103
Schistosoma mansoni thyroid hormone receptor 0.0303 0.1106 0.255
Loa Loa (eye worm) hypothetical protein 0.0255 0.0925 0.4661
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0037 0.01 0.0486
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0049 0.0146 0.0716
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0005 0.0002
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0028 0.0025
Onchocerca volvulus 0.0021 0.0039 0.0179
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0037 0.01 0.0097
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0017 0.0024 0.0102
Entamoeba histolytica hypothetical protein, conserved 0.0049 0.0146 0.361
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0264 0.096 0.0957
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0045 0.0131 0.0301
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0104 0.0101
Schistosoma mansoni coup transcription factor 0.0039 0.0106 0.0244
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.0106 0.0103
Entamoeba histolytica hypothetical protein 0.002 0.0035 0.0868
Treponema pallidum 76K protein 0.0049 0.0146 0.0188
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0045 0.0131 0.0643
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0146 0.0718
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0017 0.0024 0.0021
Loa Loa (eye worm) peptidase family M1 containing protein 0.0012 0.0005 0.0006
Echinococcus granulosus serotonin transporter 0.0045 0.0131 0.0128
Entamoeba histolytica hypothetical protein 0.0037 0.0099 0.2464
Echinococcus multilocularis Excitatory amino acid transporter 0.0127 0.044 0.0437
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0039 0.0179
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0013 0.0044
Brugia malayi hypothetical protein 0.0017 0.0024 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0094 0.0473
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0013 0.0044
Toxoplasma gondii hypothetical protein 0.0014 0.0013 0.0111
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.011 0.0107
Echinococcus granulosus sodium and chloride dependent glycine 0.0045 0.0131 0.0128
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0017 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0102
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0486
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0028 0.0065
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0104 0.0509
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0013 0.0111
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0188 0.1651
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0028 0.0025
Brugia malayi von Willebrand Factor 0.0049 0.0146 0.0718
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0106 0.0518
Echinococcus multilocularis beta adrenergic receptor kinase 0.006 0.0185 0.0182
Onchocerca volvulus 0.0045 0.0131 0.0666
Loa Loa (eye worm) hypothetical protein 0.006 0.0185 0.0917
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0037 0.01 0.0097
Loa Loa (eye worm) hypothetical protein 0.0039 0.0108 0.0526
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0079 0.0392
Brugia malayi nuclear hormone receptor 0.0039 0.0106 0.0518
Brugia malayi ecdysteroid receptor 0.0039 0.0106 0.0518
Entamoeba histolytica hypothetical protein 0.0049 0.0146 0.361
Plasmodium vivax hypothetical protein, conserved 0.0045 0.0131 0.6392
Brugia malayi photoreceptor-specific nuclear receptor 0.0039 0.0106 0.0518
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0013 0.0044
Schistosoma mansoni hypothetical protein 0.0049 0.0146 0.0335
Onchocerca volvulus 0.0049 0.0146 0.0745
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.006 0.0185 0.0427
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0123
Entamoeba histolytica hypothetical protein 0.0037 0.0099 0.2464
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0037 0.0034
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0044
Brugia malayi hypothetical protein 0.0021 0.0039 0.0179
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0102
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0127 0.044 0.0437
Onchocerca volvulus 0.0017 0.0024 0.01
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0024 0.0104
Schistosoma mansoni hypothetical protein 0.0181 0.0645 0.1487
Schistosoma mansoni ap endonuclease 0.0038 0.0104 0.024
Echinococcus granulosus glycine receptor subunit beta 0.0037 0.01 0.0097
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0106 0.0244
Brugia malayi Pre-SET motif family protein 0.0065 0.0204 0.1016
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0017 0.0024 0.0021
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0049 0.0146 0.1277
Toxoplasma gondii microneme protein MIC2 0.0049 0.0146 0.1277
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0157
Brugia malayi hypothetical protein 0.0018 0.0028 0.0126
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0028 0.0025
Trypanosoma brucei aminopeptidase, putative 0.0012 0.0005 0.0124
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0312 0.114 1
Brugia malayi hypothetical protein 0.0012 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0039 0.0106 0.0516
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0102
Toxoplasma gondii exonuclease III APE 0.0038 0.0104 0.0913
Schistosoma mansoni hypothetical protein 0.0021 0.0039 0.009
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0204 0.0201
Schistosoma mansoni nAChR subunit 0.0037 0.01 0.023
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0013 0.0111
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0104 0.0871
Schistosoma mansoni vesicular acetylcholine transporter 0.0267 0.0971 0.2237
Plasmodium falciparum transporter, putative 0.0045 0.0131 0.8941
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0044
Echinococcus multilocularis survival motor neuron protein 1 0.0255 0.0925 0.0922
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0044
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0146 0.0718
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0028 0.0126
Loa Loa (eye worm) hypothetical protein 0.006 0.0185 0.0917
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0024 0.0593
Schistosoma mansoni cpg binding protein 0.0032 0.0082 0.0189
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.0204 0.0471
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0106 0.0518
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0017 0.0024 0.0021
Onchocerca volvulus 0.0014 0.0013 0.0039
Loa Loa (eye worm) hypothetical protein 0.0049 0.0146 0.0716
Onchocerca volvulus 0.0014 0.0013 0.0039
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0042 0.0192
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0039 0.2401
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0127 0.044 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.011 0.0557
Echinococcus multilocularis regulator of G protein signaling 0.006 0.0185 0.0182
Brugia malayi nuclear receptor RXR 0.002 0.0037 0.0168
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0012 0.0005 0.0012
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0146 0.0718
Brugia malayi PAN domain containing protein 0.0014 0.0013 0.0046
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0013 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.0106 0.0516
Echinococcus multilocularis sodium and chloride dependent glycine 0.0045 0.0131 0.0128
Treponema pallidum sodium- and chloride- dependent transporter 0.0045 0.0131 0.0165
Treponema pallidum glutamate/aspartate transporter 0.0056 0.0172 0.0229
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0037 0.0168
Schistosoma mansoni rotamase 0.0036 0.0094 0.0217
Onchocerca volvulus 0.0018 0.0028 0.0123
Brugia malayi Cation transporter family protein 0.0037 0.01 0.0488
Brugia malayi nuclear receptor NHR-88 0.0039 0.0106 0.0518
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.0106 0.0516
Echinococcus multilocularis nAChR subunit 0.0037 0.01 0.0097
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0102
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0045 0.0131 0.1146
Loa Loa (eye worm) intermediate filament protein 0.0085 0.028 0.1395
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0045 0.0131 0.0641
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0079 0.6387
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0165
Schistosoma mansoni serine-rich repeat protein 0.0622 0.2318 0.5341
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0024 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.0106 0.0518
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0104 0.2577
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0017 0.0024 0.0166
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0157
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0044
Schistosoma mansoni hypothetical protein 0.0017 0.0024 0.0056
Brugia malayi Zona pellucida-like domain containing protein 0.0049 0.0146 0.0718
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0039 0.0181
Echinococcus granulosus regulator of G protein signaling 3 0.006 0.0185 0.0182
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0013 0.0044
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0037 0.01 0.023
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0013 0.0111
Brugia malayi hypothetical protein 0.006 0.0185 0.0919
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0075 0.0361
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0403 0.2113
Brugia malayi PAN domain containing protein 0.0014 0.0013 0.0046
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0037 0.01 0.0097
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0037 0.01 0.0488
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0024 0.0056
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0102
Schistosoma mansoni cpg binding protein 0.0032 0.0082 0.0189
Schistosoma mansoni neurotransmitter gated ion channel 0.0017 0.0024 0.0056
Plasmodium vivax SET domain protein, putative 0.0065 0.0204 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0185 0.0917
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0104 0.2577
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0039 0.0345
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0102
Entamoeba histolytica hypothetical protein, conserved 0.0049 0.0146 0.361
Schistosoma mansoni aminopeptidase A (M01 family) 0.0012 0.0005 0.0012
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0079 0.5264
Echinococcus granulosus dnaJ subfamily B 0.0437 0.1615 0.1612
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0012 0.0005 0.0124
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0005 0.0044
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0017 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0299 0.1092 0.5506
Loa Loa (eye worm) hypothetical protein 0.0045 0.0131 0.0641
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0017 0.0024 0.0598
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0045 0.0131 0.0641
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0099 0.0096
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0079 0.0694
Onchocerca volvulus 0.002 0.0035 0.0158
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0045 0.0131 0.1431
Onchocerca volvulus 0.0049 0.0146 0.0745
Echinococcus granulosus regulator of G protein signaling 7 0.006 0.0185 0.0182
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0185 0.0427
Brugia malayi hypothetical protein 0.0018 0.0028 0.0126
Brugia malayi hypothetical protein 0.0045 0.0131 0.0643
Loa Loa (eye worm) hypothetical protein 0.0039 0.0106 0.0516
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0039 0.2431
Echinococcus multilocularis excitatory amino acid transporter 2 0.0127 0.044 0.0437
Echinococcus granulosus cpg binding protein 0.0032 0.0082 0.0079
Loa Loa (eye worm) acetylcholine receptor protein 0.0017 0.0024 0.0102
Onchocerca volvulus 0.0039 0.0106 0.0535
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0123
Schistosoma mansoni sodium/chloride dependent transporter 0.0045 0.0131 0.0301
Chlamydia trachomatis neutral amino acid transporter 0.0056 0.0172 0.258
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0114 0.0111
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0005 0.0002
Onchocerca volvulus 0.0037 0.01 0.0503
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0486
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0037 0.01 0.0488
Onchocerca volvulus 0.0037 0.01 0.0503
Leishmania major aldehyde dehydrogenase, putative 0.0017 0.0024 0.0209
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0104 0.0717
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0037 0.01 0.023
Brugia malayi PAN domain containing protein 0.0014 0.0013 0.0046
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.0106 0.0244
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.0403 0.3507
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0017 0.0024 0.0593
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0229 0.0827 0.1906
Toxoplasma gondii aminopeptidase n, putative 0.0012 0.0005 0.0046
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1205 0.4526 0.4524
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.006 0.0185 0.0182
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0312 0.114 0.1138
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0057 0.1418
Loa Loa (eye worm) DR-78 0.0018 0.0028 0.0123
Brugia malayi Zona pellucida-like domain containing protein 0.0049 0.0146 0.0718
Echinococcus multilocularis sodium and chloride dependent glycine 0.0045 0.0131 0.0128
Schistosoma mansoni survival motor neuron protein 0.0052 0.0156 0.036
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0146 0.0718
Echinococcus multilocularis thyroid hormone receptor alpha 0.0303 0.1106 0.1104
Brugia malayi PAN domain containing protein 0.0014 0.0013 0.0046
Echinococcus granulosus vesicular acetylcholine transporter 0.0267 0.0971 0.0968
Onchocerca volvulus 0.0049 0.0146 0.0745
Toxoplasma gondii hypothetical protein 0.0045 0.0131 0.1146
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0106 0.0518
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0583 0.2167 0.4994
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.0024 0.0209
Schistosoma mansoni hypothetical protein 0.0181 0.0645 0.1487
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0018 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0486
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0079 0.0392
Brugia malayi nuclear receptor NHR-67 0.0018 0.0028 0.0126
Brugia malayi excitatory GABA receptor EXP-1A 0.0037 0.01 0.0488
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0193 0.019
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.0106 0.0535
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0104 0.0101
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0104 0.7045
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0045 0.0131 0.0643
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0104 0.5091
Brugia malayi ecdysone receptor 0.0018 0.0028 0.0126
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0157
Brugia malayi 6-phosphofructokinase 0.0117 0.0403 0.2022
Echinococcus multilocularis regulator of G protein signaling 7 0.006 0.0185 0.0182
Loa Loa (eye worm) hypothetical protein 0.0039 0.0106 0.0516
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0017 0.0024 0.0166
Entamoeba histolytica hypothetical protein 0.0037 0.0099 0.2464
Schistosoma mansoni rab6-interacting 0.0021 0.0039 0.009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0006
Echinococcus granulosus bloom syndrome protein 0.0021 0.0039 0.0036
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0017 0.0024 0.0056
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0057 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0185 0.0956
Echinococcus multilocularis axis inhibition protein axin 0.006 0.0185 0.0182
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0012 0.0005 0.0012
Echinococcus multilocularis neutral amino acid transporter A 0.0127 0.044 0.0437
Echinococcus granulosus collagen alpha 1VII chain 0.0049 0.0146 0.0142
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0037 0.01 0.0486
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0017 0.0024 0.0021
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0057 0.3716
Brugia malayi CXXC zinc finger family protein 0.0031 0.0075 0.0363
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0157
Entamoeba histolytica elongation factor-2 kinase, putative 0.0049 0.0146 0.361
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0185 0.0956
Echinococcus granulosus glycine receptor subunit beta 0.0037 0.01 0.0097
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0011 0 0.0002
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.0106 0.0103
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0028 0.0025
Echinococcus granulosus glycine receptor subunit alpha 1 0.0037 0.01 0.0097
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0127 0.044 0.3724
Onchocerca volvulus 0.0052 0.0156 0.0802
Schistosoma mansoni nAChR subunit 0.0037 0.01 0.023
Schistosoma mansoni acetylcholine receptor-related 0.0017 0.0024 0.0056
Loa Loa (eye worm) aminopeptidase N 0.0012 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0045 0.0131 0.0641
Onchocerca volvulus 0.0037 0.01 0.0503
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1156 0.4339 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0045 0.0131 0.1146
Trypanosoma cruzi aminopeptidase, putative 0.0012 0.0005 0.0124
Onchocerca volvulus 0.0021 0.0039 0.0179
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0035 0.0081
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0403 0.202
Leishmania major hypothetical protein, conserved 0.0026 0.0057 0.0501
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0204 0.1793
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0024 0.0056
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0045 0.0131 0.0128
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0017 0.0024 0.0104
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0037 0.01 0.0486
Echinococcus granulosus RUN 0.0021 0.0039 0.0036
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0252 0.0915 0.4609
Echinococcus granulosus survival motor neuron protein 1 0.0255 0.0925 0.0922
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0185 0.0956
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.011 0.0254
Schistosoma mansoni zinc finger protein 0.0018 0.0028 0.0065
Echinococcus multilocularis nAChR subunit 0.002 0.0035 0.0032
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0057 0.2806
Onchocerca volvulus 0.0014 0.0013 0.0039
Loa Loa (eye worm) phosphofructokinase 0.0117 0.0403 0.202
Toxoplasma gondii aminopeptidase N protein 0.0012 0.0005 0.0046
Schistosoma mansoni polycystin 1-related 0.0021 0.0039 0.009
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0486
Echinococcus multilocularis expressed protein 0.0036 0.0094 0.0091
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0039 0.0036
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0017 0.0024 0.0104
Echinococcus granulosus leukotriene A 4 hydrolase 0.0229 0.0827 0.0824
Onchocerca volvulus 0.002 0.0035 0.0158
Brugia malayi regulator of G-protein signaling egl-10 0.006 0.0185 0.0919
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0486
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0106 0.0518
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0157
Trypanosoma cruzi aminopeptidase, putative 0.0012 0.0005 0.0124
Echinococcus multilocularis lamin dm0 0.0085 0.028 0.0277
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0028 0.0025
Toxoplasma gondii PAN/Apple domain-containing protein 0.0014 0.0013 0.0111
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0102
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0017 0.0024 0.0166
Onchocerca volvulus 0.0014 0.0013 0.0039
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0037 0.01 0.0097
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0037 0.01 0.0097
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.01 0.0488
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0146 0.7119
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.0106 0.0103
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0079 0.0694
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0028 0.0025
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0028 0.0025
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0037 0.01 0.0488
Entamoeba histolytica hypothetical protein 0.006 0.0185 0.4593
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0017 0.0024 0.0166
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0017 0.0024 0.0021
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0037 0.01 0.023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0123
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0403 0.0929
Brugia malayi hypothetical protein 0.006 0.0185 0.0919
Plasmodium vivax thrombospondin-related anonymous protein 0.0049 0.0146 0.7119
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0049 0.0146 1
Echinococcus multilocularis RUN 0.0021 0.0039 0.0036
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0045 0.0131 0.0128
Schistosoma mansoni cpg binding protein 0.0031 0.0075 0.0174
Echinococcus granulosus beta-adrenergic receptor kinase 0.006 0.0185 0.0182
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0106 0.0244
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.0017 0.0024 0.0543
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.01 0.0488
Schistosoma mansoni regulator of G protein signaling 0.006 0.0185 0.0427
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.011 0.2729
Echinococcus multilocularis tumor protein p63 0.0348 0.1276 0.1274
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0204 0.0471
Entamoeba histolytica hypothetical protein 0.0037 0.0099 0.2464
Echinococcus granulosus excitatory amino acid transporter 2 0.0127 0.044 0.0437
Loa Loa (eye worm) hypothetical protein 0.0049 0.0146 0.0716
Brugia malayi hypothetical protein 0.0012 0.0005 0.0008
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.0106 0.0244
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0039 0.0036
Loa Loa (eye worm) RecQ helicase 0.0021 0.0039 0.0179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.0106 0.0516
Echinococcus multilocularis glycine receptor subunit beta 0.0037 0.01 0.0097
Echinococcus granulosus axis inhibition protein axin 0.006 0.0185 0.0182
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.0403 0.3535
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.0106 0.0244
Echinococcus multilocularis regulator of G protein signaling 3 0.006 0.0185 0.0182
Loa Loa (eye worm) LGC-31 protein 0.0037 0.01 0.0486
Schistosoma mansoni DNA helicase recq1 0.0021 0.0039 0.0091
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0017 0.0024 0.0166
Brugia malayi conserved hypotetical protein 0.0018 0.0028 0.0126
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.011 0.2729
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.011 0.0107
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0104 0.0525
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0024 0.0056
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0486
Schistosoma mansoni hypothetical protein 0.0437 0.1615 0.3722
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.0106 0.0516
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0185 0.0956
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0185 0.0427
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0045 0.0131 0.0301
Schistosoma mansoni rab6-interacting 0.0021 0.0039 0.009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0102
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0005 0.0002
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0079 0.0392
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0039 0.0106 0.0516
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0017 0.0024 0.0166
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0057 0.3716
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0028 0.0126
Echinococcus granulosus nAChR subunit 0.0037 0.01 0.0097
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0079 0.3868
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.006 0.0185 0.0917
Echinococcus multilocularis cpg binding protein 0.0032 0.0082 0.0079
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0059 0.0183 0.0179
Echinococcus granulosus regulator of G protein signaling 7 0.006 0.0185 0.0182
Echinococcus multilocularis vesicular acetylcholine transporter 0.0267 0.0971 0.0968
Onchocerca volvulus 0.0014 0.0013 0.0039
Echinococcus granulosus lamin dm0 0.0085 0.028 0.0277
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0037 0.01 0.0097
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0017 0.0024 0.0166
Loa Loa (eye worm) hypothetical protein 0.0039 0.0106 0.0516
Echinococcus granulosus regulator of G protein signaling 3 0.006 0.0185 0.0182
Echinococcus granulosus lamin 0.0085 0.028 0.0277
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0014 0.0013 0.0111
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0049 0.0146 1
Schistosoma mansoni lipoxygenase 0.0021 0.0039 0.009
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0035 0.0159
Loa Loa (eye worm) hypothetical protein 0.0065 0.0204 0.1014
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0486
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0049 0.0146 0.7119
Echinococcus multilocularis regulator of G protein signaling 3 0.006 0.0185 0.0182
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0079 0.1961
Schistosoma mansoni nuclear receptor 0.0018 0.0028 0.0065
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0146 0.0718
Schistosoma mansoni lamin 0.0085 0.028 0.0645
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0037 0.01 0.0486
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.0403 0.0587
Leishmania major hypothetical protein, conserved 0.0022 0.0042 0.0366
Onchocerca volvulus 0.0045 0.0131 0.0666
Brugia malayi A-kinase anchor protein 10, precursor 0.006 0.0185 0.0919
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0042 0.0039
Onchocerca volvulus 0.0017 0.0024 0.01
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0403 1
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0017 0.0024 0.0166
Loa Loa (eye worm) hypothetical protein 0.0049 0.0146 0.0716
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0102
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0017 0.0024 0.0211
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0037 0.01 0.0486
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0079 0.0085
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0486
Loa Loa (eye worm) solute carrier family 6 member 4 0.0045 0.0131 0.0641
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0102
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0012 0.0005 0.0124
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0215 0.0495
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0045 0.0131 0.0643
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0486
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0044
Chlamydia trachomatis glutamate symporter 0.0127 0.044 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0039 0.0036
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0037 0.01 0.023
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0045 0.0131 0.0643
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0028 0.0123
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0017 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0299 0.1092 0.5506
Loa Loa (eye worm) hypothetical protein 0.0049 0.0146 0.0716
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0024 0.0593
Brugia malayi hypothetical protein 0.0021 0.0039 0.0179
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0104 0.0525
Brugia malayi hypothetical protein 0.002 0.0037 0.0168
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0005 0.0008
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0037 0.01 0.0488
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0037 0.01 0.0488
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0017 0.0024 0.0211
Plasmodium falciparum thrombospondin-related anonymous protein 0.0049 0.0146 1
Echinococcus multilocularis expressed protein 0.1162 0.4362 0.436
Echinococcus multilocularis excitatory amino acid transporter 3 0.0127 0.044 0.0437
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.0106 0.0244
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.0106 0.0518
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0079 0.0392
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.011 0.2729
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0024 0.0104
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.0106 0.0516
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0028 0.0126
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0039 0.2431
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0152 0.035
Loa Loa (eye worm) hypothetical protein 0.0533 0.1981 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0204 0.0471
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0039 0.0036
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.0024 0.0593
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0017 0.0024 0.0598
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0005 0.0044
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.01 0.0488
Brugia malayi hypothetical protein 0.0017 0.0023 0.0096
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0165
Onchocerca volvulus 0.0037 0.01 0.0503
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0037 0.01 0.0488
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0024 0.0593
Brugia malayi hypothetical protein 0.0017 0.0024 0.0104
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0123
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0039 0.0036
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0204 0.0201
Brugia malayi hypothetical protein 0.0255 0.0925 0.4662
Brugia malayi hypothetical protein 0.0017 0.0024 0.0104
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0229 0.0827 0.4164
Onchocerca volvulus 0.0037 0.01 0.0503
Echinococcus granulosus glycine receptor subunit alpha 1 0.0037 0.01 0.0097
Loa Loa (eye worm) hypothetical protein 0.006 0.0185 0.0917
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0104 0.2577
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0102
Loa Loa (eye worm) PXA domain-containing protein 0.006 0.0185 0.0917
Loa Loa (eye worm) hypothetical protein 0.0039 0.0106 0.0516
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0037 0.01 0.0488
Toxoplasma gondii microneme protein MIC4 0.0014 0.0013 0.0111
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0486
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0039 0.0181
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.0106 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.004 0.011 0.0557
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0024 0.0593
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0486
Loa Loa (eye worm) hypothetical protein 0.0045 0.0131 0.0641
Entamoeba histolytica hypothetical protein 0.006 0.0185 0.4593
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.0024 0.0593
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0012 0.0005 0.0124
Loa Loa (eye worm) hypothetical protein 0.0339 0.1243 0.627
Echinococcus granulosus neutral amino acid transporter A 0.0127 0.044 0.0437
Leishmania major aldehyde dehydrogenase, putative 0.0017 0.0024 0.0209
Schistosoma mansoni sodium/chloride dependent transporter 0.0045 0.0131 0.0301
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0017 0.0024 0.0593
Echinococcus multilocularis excitatory amino acid transporter 2 0.0127 0.044 0.0437
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0123
Echinococcus granulosus sodium:dicarboxylate symporter 0.0127 0.044 0.0437
Schistosoma mansoni nAChR subunit 0.0017 0.0024 0.0056
Echinococcus multilocularis serotonin transporter 0.0045 0.0131 0.0128
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0146 0.0718
Toxoplasma gondii hypothetical protein 0.0045 0.0131 0.1146
Brugia malayi Cache domain containing protein 0.0533 0.1981 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.0106 0.0244
Entamoeba histolytica hypothetical protein 0.006 0.0185 0.4593
Echinococcus multilocularis Excitatory amino acid transporter 0.0127 0.044 0.0437
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0204 0.0471
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0039 0.0181
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0131 0.0642
Onchocerca volvulus 0.0049 0.0146 0.0745
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0028 0.0025
Schistosoma mansoni lamin 0.0085 0.028 0.0645
Onchocerca volvulus 0.0014 0.0013 0.0039
Loa Loa (eye worm) hypothetical protein 0.0045 0.0131 0.0641
Loa Loa (eye worm) RGS-3 protein 0.006 0.0185 0.0917
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.011 0.0539
Brugia malayi intermediate filament protein 0.0085 0.028 0.1397
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0123
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0299 0.1092 0.2517
Echinococcus granulosus neutral amino acid transporter A 0.0127 0.044 0.0437
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0123
Toxoplasma gondii microneme protein MIC17A 0.0014 0.0013 0.0111
Onchocerca volvulus 0.0051 0.0152 0.0779
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0039 0.0036
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0049 0.0146 0.0142
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0004 0.0001
Brugia malayi TATA binding protein associated factor 0.0012 0.0005 0.0008
Brugia malayi PAN domain containing protein 0.0014 0.0013 0.0046
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.006 0.0185 0.0427
Toxoplasma gondii aminopeptidase N, putative 0.0012 0.0005 0.0046
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0045 0.0131 0.0643
Schistosoma mansoni axis inhibition protein axin 0.006 0.0185 0.0427
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0037 0.01 0.0097
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0123
Schistosoma mansoni regulator of G protein signaling 0.006 0.0185 0.0427
Brugia malayi hypothetical protein 0.0026 0.0057 0.0272
Brugia malayi Immunoglobulin I-set domain containing protein 0.0049 0.0146 0.0718
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0091 0.2256
Brugia malayi phosphofructokinase 0.0117 0.0403 0.2022
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.002 0.0035 0.0081
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0127 0.044 0.0437
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.006 0.0185 0.0956
Onchocerca volvulus 0.0018 0.0028 0.0123
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0192
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0045 0.0131 0.0301
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0165
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0028 0.0123
Onchocerca volvulus 0.0085 0.028 0.1458
Echinococcus granulosus aminopeptidase N 0.0012 0.0005 0.0002
Schistosoma mansoni acetylcholine receptor subunit beta 0.0017 0.0024 0.0056
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0165
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0045 0.0131 0.0128
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0005 0.0002
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0403 0.2113
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0037 0.01 0.0097
Schistosoma mansoni nAChR subunit 0.0037 0.01 0.023
Schistosoma mansoni nAChR subunit 0.0017 0.0024 0.0056
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0486
Echinococcus multilocularis axis inhibition protein axin 0.006 0.0185 0.0182
Schistosoma mansoni hypothetical protein 0.0037 0.0099 0.0229
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0123
Brugia malayi Pre-SET motif family protein 0.0447 0.1655 0.8351
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0157
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0039 0.1904
Mycobacterium ulcerans aldehyde dehydrogenase 0.0017 0.0024 0.0166
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0037 0.0034
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0102
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0486
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0106 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0102
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.01 0.0488
Schistosoma mansoni hypothetical protein 0.0022 0.0042 0.0097
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0057 0.1418
Loa Loa (eye worm) hypothetical protein 0.006 0.0185 0.0917
Onchocerca volvulus 0.0014 0.0013 0.0039
Toxoplasma gondii aldehyde dehydrogenase 0.0312 0.114 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0037 0.0165
Schistosoma mansoni neurotransmitter gated ion channel 0.0017 0.0024 0.0056
Echinococcus granulosus Excitatory amino acid transporter 0.0127 0.044 0.0437
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0146 0.0718
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0146 0.0718
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.0042 0.2049
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0028 0.0123
Brugia malayi Protein kinase domain containing protein 0.0022 0.0042 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.0106 0.0518
Schistosoma mansoni nAChR subunit 0.0037 0.01 0.023
Brugia malayi hypothetical protein 0.002 0.0037 0.0168
Brugia malayi Cation transporter family protein 0.0037 0.01 0.0488
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0099 0.0096
Mycobacterium ulcerans aldehyde dehydrogenase 0.0312 0.114 1
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0013 0.0111
Schistosoma mansoni hypothetical protein 0.0049 0.0146 0.0335
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.011 0.0107
Schistosoma mansoni hypothetical protein 0.0264 0.096 0.2211
Brugia malayi nuclear hormone receptor 0.0018 0.0028 0.0126
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0123
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0028 0.0065
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0127 0.044 0.2308
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0104 0.0506
Echinococcus granulosus FTZ F1 alpha 0.0039 0.0106 0.0103
Loa Loa (eye worm) TATA binding protein associated factor 0.0012 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0039 0.0106 0.0516
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.006 0.0185 0.0917
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.006 0.0185 0.0919
Loa Loa (eye worm) serotonin transporter b 0.0045 0.0131 0.0641
Brugia malayi Regulator of G protein signaling domain containing protein 0.006 0.0185 0.0919
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0486
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0024 0.0593
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0017 0.0024 0.0209
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0079 0.0392
Treponema pallidum glutamate transporter 0.0056 0.0172 0.0229
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0037 0.0085
Onchocerca volvulus 0.0065 0.0204 0.1058
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0017 0.0024 0.0021
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0037 0.01 0.023
Echinococcus granulosus expressed protein 0.1162 0.4362 0.436
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0037 0.01 0.0097
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0005 0.0008
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0104 0.0911
Echinococcus granulosus voltage dependent calcium channel subunit 0.1205 0.4526 0.4524
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0017 0.0024 0.0104
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0056 0.0172 0.0397
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0035 0.0159
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0085 0.028 0.1395
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.011 0.0107
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0045 0.0131 0.0128
Brugia malayi 6-phosphofructokinase 0.0117 0.0403 0.2022
Brugia malayi follicle stimulating hormone receptor 0.0252 0.0915 0.461
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0042 0.1034
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0028 0.0126
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0079 0.0392
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0106 0.0518
Echinococcus multilocularis glycine receptor subunit beta 0.0037 0.01 0.0097
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.0106 0.0518
Schistosoma mansoni thyroid hormone receptor 0.0303 0.1106 0.255
Schistosoma mansoni loxhd1 0.0021 0.0039 0.009
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.0106 0.0103
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0039 0.0343
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0017 0.0024 0.0166
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0024 0.0104
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0403 0.2113
Brugia malayi PAN domain containing protein 0.0014 0.0013 0.0046
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0049 0.0146 0.0716
Echinococcus granulosus tumor protein p63 0.0348 0.1276 0.1274
Brugia malayi hypothetical protein 0.013 0.0452 0.2268
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0104 0.2363
Mycobacterium ulcerans aldehyde dehydrogenase 0.0312 0.114 1
Schistosoma mansoni regulator of G protein signaling 0.006 0.0185 0.0427
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0091 0.2256
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0039 0.1769
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0037 0.01 0.0488
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.011 1
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0229 0.0827 0.0824
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0106 0.0103
Echinococcus granulosus sodium and chloride dependent glycine 0.0045 0.0131 0.0128
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0403 0.0929
Schistosoma mansoni sodium-dependent amino acid transporter 0.0045 0.0131 0.0301
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.0106 0.0244
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0486
Brugia malayi PAN domain containing protein 0.0014 0.0013 0.0046
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.0028 0.0123
Echinococcus granulosus expressed protein 0.0036 0.0094 0.0091
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0017 0.0024 0.0593
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0079 0.0694
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.011 0.0965
Onchocerca volvulus 0.0014 0.0013 0.0039
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0045 0.0131 0.0301
Trypanosoma cruzi Aminopeptidase M1, putative 0.0012 0.0005 0.0124
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0017 0.0024 0.0593
Loa Loa (eye worm) hypothetical protein 0.0049 0.0146 0.0716
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0017 0.0024 0.0104
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0037 0.01 0.0097
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0056 0.0172 0.0169
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0037 0.01 0.0488
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0091 0.0797
Echinococcus multilocularis Regulator of G protein signaling 20 0.006 0.0185 0.0182
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0044
Brugia malayi Aldehyde dehydrogenase protein 4 0.0017 0.0024 0.0104
Schistosoma mansoni nAChR subunit 0.0037 0.01 0.023
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0017 0.0024 0.0166
Schistosoma mansoni nAChR subunit 0.0037 0.01 0.023
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0013 0.0111
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0039 0.0971
Loa Loa (eye worm) ACC-1 protein 0.0037 0.01 0.0486
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0099 0.0229
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0486
Schistosoma mansoni nuclear receptor 0.0018 0.0028 0.0065
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0123
Loa Loa (eye worm) GABA receptor subunit 0.002 0.0035 0.0157
Loa Loa (eye worm) hypothetical protein 0.0039 0.0106 0.0516
Loa Loa (eye worm) hypothetical protein 0.0049 0.0146 0.0716
Loa Loa (eye worm) hypothetical protein 0.0049 0.0146 0.0716
Loa Loa (eye worm) hypothetical protein 0.0045 0.0131 0.0641
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0039 0.0345
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0123
Loa Loa (eye worm) hypothetical protein 0.0041 0.0114 0.0556
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0017 0.0024 0.0593
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.0106 0.0516
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0094 0.0457
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0017 0.0024 0.0211
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0106 0.0103
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0017 0.0024 0.0102
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0102
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0037 0.01 0.0097
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0267 0.0971 0.5128
Loa Loa (eye worm) norepinephrine transporter 0.0045 0.0131 0.0641
Brugia malayi steroid hormone receptor 0.0039 0.0106 0.0518
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0312 0.114 1
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0037 0.01 0.0097
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0037 0.01 0.0097
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0057 0.0503
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0059 0.0183 0.0179
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0017 0.0024 0.0211
Echinococcus multilocularis musashi 0.0085 0.028 0.0277
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0117 0.0403 1
Echinococcus granulosus excitatory amino acid transporter 3 0.0127 0.044 0.0437
Echinococcus granulosus neutral amino acid transporter 0.0127 0.044 0.0437
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0028 0.0126
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.0106 0.0103
Echinococcus granulosus geminin 0.0181 0.0645 0.0642
Brugia malayi Cation transporter family protein 0.0037 0.01 0.0488
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0017 0.0024 0.0593
Brugia malayi PAN domain containing protein 0.0014 0.0013 0.0046
Onchocerca volvulus 0.0014 0.0013 0.0039
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0079 0.3868
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0079 0.5264
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0017 0.0024 0.0166
Loa Loa (eye worm) hypothetical protein 0.004 0.011 0.0537
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.002 0.0035 0.0159
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0017 0.0024 0.0166
Toxoplasma gondii kringle domain-containing protein 0.0022 0.0042 0.0367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.0106 0.0516
Trypanosoma brucei Aminopeptidase M1, putative 0.0012 0.0005 0.0124
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.172 0.6478 1
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.011 0.0107
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0039 0.0181
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0264 0.096 0.0957
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.0106 0.0518
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0486
Loa Loa (eye worm) excitatory amino acid transporter 0.0127 0.044 0.2205
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0057 0.1418
Onchocerca volvulus 0.0014 0.0013 0.0039
Loa Loa (eye worm) CUTiclin-Like family member 0.0049 0.0146 0.0716
Loa Loa (eye worm) CUTiclin family member 0.0049 0.0146 0.0716
Loa Loa (eye worm) hypothetical protein 0.0051 0.0152 0.0748
Trichomonas vaginalis set domain proteins, putative 0.0509 0.1889 1
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0056 0.0172 0.0169
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0114 0.0111
Schistosoma mansoni axis inhibition protein axin 0.006 0.0185 0.0427
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0039 0.0181
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0045 0.0131 0.0128
Loa Loa (eye worm) ACC-1 protein 0.0037 0.01 0.0486
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.0106 0.0518
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0039 0.0177
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0012 0.0005 0.0002
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0039 0.0036
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0039 0.0108 0.0526
Brugia malayi nuclear receptor RXR 0.0018 0.0028 0.0126
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0012 0.0005 0.0124
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0017 0.0024 0.0021
Brugia malayi vesicular acetylcholine transporter unc-17 0.0267 0.0971 0.4893
Loa Loa (eye worm) hypothetical protein 0.0049 0.0146 0.0716
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0035 0.0159
Brugia malayi nuclear receptor NHR-88 0.0018 0.0028 0.0126
Onchocerca volvulus 0.0509 0.1889 1
Brugia malayi hypothetical protein 0.0037 0.0099 0.0485
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0104 0.929
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0037 0.01 0.0097
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0049 0.0146 0.7119
Echinococcus multilocularis dnaJ subfamily B 0.0437 0.1615 0.1612
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0403 1
Toxoplasma gondii microneme protein MIC17C 0.0014 0.0013 0.0111
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0017 0.0024 0.0021
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.011 0.0557
Schistosoma mansoni sodium/chloride dependent transporter 0.0045 0.0131 0.0301
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0157
Onchocerca volvulus 0.0031 0.0075 0.0372
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0049 0.0146 0.0745
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0045 0.0131 0.0301
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0006
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0403 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0017 0.0024 0.0021
Onchocerca volvulus Putative nachr subunit 0.0037 0.01 0.0503
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0017 0.0024 0.0102
Entamoeba histolytica aminopeptidase, putative 0.0012 0.0005 0.013
Schistosoma mansoni intermediate filament proteins 0.0085 0.028 0.0645
Trypanosoma brucei Aminopeptidase M1, putative 0.0012 0.0005 0.0124
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0013 0.0111
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0486
Echinococcus granulosus axis inhibition protein axin 0.006 0.0185 0.0182
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0403 0.2113
Onchocerca volvulus 0.0049 0.0146 0.0745
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0102
Brugia malayi Regulator of G protein signaling domain containing protein 0.006 0.0185 0.0919
Schistosoma mansoni ap endonuclease 0.0038 0.0104 0.024
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.011 0.0107
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0017 0.0024 0.01
Echinococcus granulosus Regulator of G protein signaling 20 0.006 0.0185 0.0182
Plasmodium vivax amine transporter, putative 0.0045 0.0131 0.6392
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0039 0.0036
Echinococcus multilocularis regulator of G protein signaling 7 0.006 0.0185 0.0182
Onchocerca volvulus 0.0049 0.0146 0.0745
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0028 0.0065
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0012 0.0005 0.0124
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0028 0.0065
Echinococcus multilocularis geminin 0.0181 0.0645 0.0642
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0299 0.1092 0.2517
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0127 0.044 0.1014
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0017 0.0024 0.0593
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0102
Trichomonas vaginalis rotamase, putative 0.0035 0.0091 0.0456
Echinococcus granulosus excitatory amino acid transporter 2 0.0127 0.044 0.0437
Brugia malayi PXA domain containing protein 0.006 0.0185 0.0919
Brugia malayi aldehyde dehydrogenase 0.0017 0.0024 0.0104
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0104 0.0124
Echinococcus multilocularis neutral amino acid transporter A 0.0127 0.044 0.0437
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0017 0.0024 0.0102
Schistosoma mansoni hypothetical protein 0.0622 0.2318 0.5341
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0447 0.1655 0.835
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0006
Brugia malayi Excitatory amino acid transporter 0.0127 0.044 0.2206
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0177
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.0106 0.0103
Loa Loa (eye worm) hypothetical protein 0.0083 0.0274 0.1366
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0299 0.1092 0.109
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0403 0.202
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0045 0.0131 0.1146
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0005 0.0002
Brugia malayi Doublecortin family protein 0.0021 0.0039 0.0179
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0037 0.01 0.0097
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0005 0.0002
Echinococcus granulosus intermediate filament protein 0.0085 0.028 0.0277
Leishmania major aldehyde dehydrogenase, putative 0.0017 0.0024 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0185 0.0956
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0037 0.01 0.0486
Brugia malayi hypothetical protein 0.0049 0.0146 0.0718
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0299 0.1092 0.2517
Onchocerca volvulus 0.0049 0.0146 0.0745
Loa Loa (eye worm) hypothetical protein 0.0049 0.0146 0.0716
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0185 0.0956
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0017 0.0024 0.01
Onchocerca volvulus 0.0014 0.0013 0.0039
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.011 0.0254
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0267 0.0971 0.4891
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.027
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0037 0.01 0.0097
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2649 1 1
Schistosoma mansoni nAChR subunit 0.0037 0.01 0.023
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.0106 0.0103
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0012 0.0005 0.0255
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0028 0.0123
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0179
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.0106 0.0535
Schistosoma mansoni regulator of G protein signaling 0.006 0.0185 0.0427
Echinococcus multilocularis neutral amino acid transporter A 0.0127 0.044 0.0437
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.01 0.0488
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0028 0.0065
Schistosoma mansoni hypothetical protein 0.0052 0.0156 0.036
Brugia malayi tailless protein 0.0018 0.0028 0.0126
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0004 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0106 0.0103
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0005 0.0044
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0204 0.0201
Onchocerca volvulus Bile acid receptor homolog 0.0039 0.0106 0.0535
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0045 0.0131 0.0301
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0017 0.0024 0.0598
Brugia malayi PAN domain containing protein 0.0014 0.0013 0.0046
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0049 0.0146 0.7119
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0017 0.0024 0.0166
Loa Loa (eye worm) hypothetical protein 0.0049 0.0146 0.0716
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.0403 0.04
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0005 0.0008
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0017 0.0024 0.0598
Schistosoma mansoni aldehyde dehydrogenase 0.0312 0.114 0.2628
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0037 0.01 0.0097
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0091 0.0799
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0044
Loa Loa (eye worm) hypothetical protein 0.0049 0.0146 0.0716
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0037 0.0168
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0049 0.0146 0.0718
Schistosoma mansoni regulator of G protein signaling 0.006 0.0185 0.0427
Brugia malayi PAN domain containing protein 0.0014 0.0013 0.0046
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.01 0.0488
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0085 0.028 0.1395
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0039 0.0036
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0005 0.0002
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0104 0.2581
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0017 0.0024 0.0021
Brugia malayi hypothetical protein 0.0017 0.0024 0.0104
Schistosoma mansoni lipoxygenase 0.0059 0.0183 0.0421
Echinococcus granulosus glycine receptor subunit alpha 1 0.0037 0.01 0.0097
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.0024 0.0593
Onchocerca volvulus 0.0045 0.0131 0.0666
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0039 0.0976
Brugia malayi Kringle domain containing protein 0.0022 0.0042 0.0194
Schistosoma mansoni aldehyde dehydrogenase 0.0312 0.114 0.2628
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0486
Echinococcus multilocularis aminopeptidase N 0.0012 0.0005 0.0002
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0028 0.0126
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0017 0.0024 0.0056
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0012 0.0005 0.0255
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0056 0.0172 0.0397
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0866 0.3242 0.324
Schistosoma mansoni neurotransmitter gated ion channel 0.002 0.0035 0.0081
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0037 0.01 0.0097
Loa Loa (eye worm) hypothetical protein 0.0049 0.0146 0.0716

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 200 nM Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles ChEMBL. 2724295
IC50 (binding) = 200 nM Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles ChEMBL. 2724295
IC50 (binding) = 300 nM Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles ChEMBL. 2724295
IC50 (binding) = 300 nM Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles ChEMBL. 2724295
LD50 (ADMET) = 6.2 uM kg-1 Lethal dose of the compound, when administered intraperitoneally in mice ChEMBL. 2724295
LD50 (ADMET) = 6.2 uM kg-1 Lethal dose of the compound, when administered intraperitoneally in mice ChEMBL. 2724295
LD50 (ADMET) = 12 uM kg-1 Lethal dose of the compound, when administered intraperitoneally in mice ChEMBL. 2724295
LD50 (ADMET) = 12 uM kg-1 Lethal dose of the compound, when administered intraperitoneally in mice ChEMBL. 2724295

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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