Detailed information for compound 258325

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 543.691 | Formula: C31H45NO7
  • H donors: 1 H acceptors: 5 LogP: 4.61 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=CC12CC3C(C2(C(=O)O)C(=C3)C(C)C)(CC2C1CC[C@H]2C)CCOC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C
  • InChi: 1S/C31H45NO7/c1-18(2)23-14-20-15-30(17-33)22-10-9-19(3)21(22)16-29(20,31(23,30)26(35)36)11-13-38-25(34)24-8-7-12-32(24)27(37)39-28(4,5)6/h14,17-22,24H,7-13,15-16H2,1-6H3,(H,35,36)/t19-,20?,21?,22?,24+,29?,30?,31?/m1/s1
  • InChiKey: VKOMWZFRODGSKR-BKSODZDSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cyclin B3 1 0.0038 0.0018 0.0018
Echinococcus multilocularis calpain 5 0.0077 0.0147 0.0147
Schistosoma mansoni cyclins 0.0038 0.0018 0.0006
Trichomonas vaginalis synaptotagmin, putative 0.0077 0.0147 0.0544
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0014 0.0007
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0014 0.0007
Trichomonas vaginalis synaptotagmin, putative 0.0077 0.0147 0.0544
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0077 0.0147 0.0147
Toxoplasma gondii hypothetical protein 0.0077 0.0147 0.0567
Echinococcus granulosus cyclins 0.0038 0.0018 0.0018
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.0016 0.0016
Trichomonas vaginalis AGC family protein kinase 0.068 0.2154 0.8654
Echinococcus multilocularis serine:threonine protein kinase N2 0.068 0.2154 0.2154
Schistosoma mansoni serine/threonine protein kinase 0.0299 0.0886 0.0875
Trypanosoma brucei glucosidase, putative 0.0036 0.0012 0.0025
Trichomonas vaginalis synaptotagmin, putative 0.0077 0.0147 0.0544
Echinococcus granulosus synaptotagmin 0.0077 0.0147 0.0147
Onchocerca volvulus 0.0571 0.1792 0.3333
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0016 0.0016
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0037 0.0014 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Brugia malayi C2 domain containing protein 0.0077 0.0147 0.0143
Trichomonas vaginalis Proline-rich protein, putative 0.0077 0.0147 0.0544
Echinococcus granulosus synaptotagmin 0.0077 0.0147 0.0147
Schistosoma mansoni serine/threonine protein kinase 0.0496 0.154 0.153
Trichomonas vaginalis cyclin B, putative 0.0038 0.0018 0.0024
Loa Loa (eye worm) raf kinase 0.0494 0.1537 0.1534
Echinococcus multilocularis cyclin b3 0.0038 0.0018 0.0018
Echinococcus multilocularis protein kinase c iota type 0.1354 0.4396 0.4396
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0037 0.0016 0.0016
Entamoeba histolytica PH domain containing protein kinase, putative 0.079 0.2521 0.4219
Brugia malayi C2 domain containing protein 0.0077 0.0147 0.0143
Trypanosoma cruzi NIMA-related kinase, putative 0.0037 0.0014 0.0032
Echinococcus granulosus protein kinase c eta type 0.0494 0.1537 0.1537
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0003 0.0003
Brugia malayi RhoGEF domain containing protein 0.0494 0.1537 0.1534
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0014 0.0007
Schistosoma mansoni synaptotagmin 12 0.0077 0.0147 0.0135
Entamoeba histolytica hypothetical protein 0.0375 0.1139 0.1896
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0108 0.025 0.0238
Schistosoma mansoni serine/threonine kinase 0.068 0.2154 0.2145
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0077 0.0147 0.0147
Brugia malayi diacylglycerol kinase 0.0494 0.1537 0.1534
Echinococcus granulosus protein piccolo 0.0077 0.0147 0.0147
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0063 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Plasmodium falciparum cGMP-dependent protein kinase 0.0063 0.0102 0.0387
Loa Loa (eye worm) hypothetical protein 0.0181 0.0493 0.049
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0077 0.0147 0.0147
Echinococcus multilocularis synaptotagmin 15 0.0077 0.0147 0.0147
Schistosoma mansoni regulator of G protein signaling 0.0108 0.025 0.0238
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0102 0.009
Echinococcus multilocularis UNCoordinated family member (unc 13) 0.0077 0.0147 0.0147
Trypanosoma cruzi cyclin, putative 0.0038 0.0018 0.0049
Echinococcus multilocularis tyrosine protein kinase Blk 0.0034 0.0003 0.0003
Entamoeba histolytica Rap/Ran GTPase activating protein, putative 0.0077 0.0147 0.0226
Trypanosoma cruzi C2 domain containing protein, putative 0.0077 0.0147 0.0567
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Echinococcus multilocularis myoferlin 0.0077 0.0147 0.0147
Toxoplasma gondii Elicitor-responsive protein, putative 0.0077 0.0147 0.0567
Brugia malayi PXA domain containing protein 0.0108 0.025 0.0247
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0483 0.1499 0.1496
Schistosoma mansoni synaptotagmin 0.0077 0.0147 0.0135
Loa Loa (eye worm) hypothetical protein 0.0108 0.025 0.0247
Onchocerca volvulus 0.0077 0.0147 0.0242
Brugia malayi glutaminase DH11.1 0.0274 0.0804 0.0801
Toxoplasma gondii hypothetical protein 0.0077 0.0147 0.0567
Echinococcus multilocularis protein kinase c eta type 0.0494 0.1537 0.1537
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Schistosoma mansoni nedd-4-like E3 ubiquitin-protein ligase 0.0077 0.0147 0.0135
Brugia malayi Synapse defective protein 1 0.0077 0.0147 0.0143
Echinococcus multilocularis Regulator of G protein signaling 20 0.0108 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Echinococcus granulosus Immunoglobulin E set 0.0077 0.0147 0.0147
Brugia malayi Protein kinase domain containing protein 0.004 0.0024 0.002
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0037 0.0016 0.0016
Trichomonas vaginalis AGC family protein kinase 0.069 0.2188 0.879
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0014 0.0007
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.078 0.2487 1
Giardia lamblia Kinase, AGC PKA 0.078 0.2487 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0591 0.1858 0.1855
Echinococcus multilocularis synaptotagmin 0.0077 0.0147 0.0147
Loa Loa (eye worm) cyclin domain-containing protein 0.0038 0.0018 0.0014
Schistosoma mansoni regulator of G protein signaling 0.0108 0.025 0.0238
Schistosoma mansoni copine 0.0077 0.0147 0.0135
Schistosoma mansoni unc-13 (munc13) 0.0571 0.1792 0.1782
Loa Loa (eye worm) hypothetical protein 0.0108 0.025 0.0247
Echinococcus granulosus serine:threonine protein kinase N2 0.068 0.2154 0.2154
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.078 0.2487 0.2487
Trypanosoma cruzi Coiled-coil and C2 domain-containing protein 0.0077 0.0147 0.0567
Brugia malayi p70 ribosomal S6 kinase beta 0.068 0.2154 0.2151
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Trichomonas vaginalis vab10 spectraplakin, putative 0.0077 0.0147 0.0544
Schistosoma mansoni tyrosine kinase 0.0037 0.0016 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Echinococcus multilocularis synaptotagmin 0.0077 0.0147 0.0147
Echinococcus granulosus Regulator of G protein signaling 20 0.0108 0.025 0.025
Plasmodium vivax double C2-like domain-containing protein, putative 0.0077 0.0147 0.0567
Entamoeba histolytica protein kinase, putative 0.069 0.2188 0.3659
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0147 0.0567
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0108 0.025 0.025
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.078 0.2487 1
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.0077 0.0147 0.0135
Onchocerca volvulus 0.0077 0.0147 0.0242
Entamoeba histolytica hypothetical protein 0.0077 0.0147 0.0226
Loa Loa (eye worm) hypothetical protein 0.0505 0.1571 0.1568
Onchocerca volvulus 0.0077 0.0147 0.0242
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0077 0.0147 0.0147
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.078 0.2487 0.2487
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.078 0.2487 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0108 0.025 0.0238
Echinococcus granulosus N chimaerin 0.0498 0.1549 0.1549
Trichomonas vaginalis copine, putative 0.0077 0.0147 0.0544
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0077 0.0147 0.0135
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0037 0.0014 0.0032
Trichomonas vaginalis cyclin B, putative 0.0038 0.0018 0.0024
Loa Loa (eye worm) PXA domain-containing protein 0.0108 0.025 0.0247
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0435 0.0435
Schistosoma mansoni protein kinase C mu 0.0702 0.2227 0.2218
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0037 0.0016 0.0016
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0037 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0108 0.025 0.0247
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0498 0.1549 0.1539
Brugia malayi Cyclin, N-terminal domain containing protein 0.0038 0.0018 0.0014
Echinococcus granulosus synaptotagmin 15 0.0077 0.0147 0.0147
Trypanosoma brucei protein kinase, putative 0.0037 0.0014 0.0032
Trichomonas vaginalis cyclins, putative 0.0038 0.0018 0.0024
Trichomonas vaginalis AGC family protein kinase 0.069 0.2188 0.879
Echinococcus multilocularis regulator of G protein signaling 7 0.0108 0.025 0.025
Echinococcus granulosus raf serine:threonine protein kinase 0.0496 0.154 0.154
Toxoplasma gondii ferlin family protein 0.0077 0.0147 0.0567
Echinococcus multilocularis regulator of G protein signaling 3 0.0108 0.025 0.025
Entamoeba histolytica hypothetical protein 0.0108 0.025 0.04
Schistosoma mansoni serine/threonine-protein kinase 0.0037 0.0014 0.0002
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0006 0.0006
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.1388 0.4511 0.4511
Brugia malayi Synapse defective protein 1 0.0077 0.0147 0.0143
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0702 0.2227 0.2224
Brugia malayi WW domain containing protein 0.0077 0.0147 0.0143
Leishmania major hypothetical protein, conserved 0.0077 0.0147 0.0567
Schistosoma mansoni serine/threonine protein kinase 0.0521 0.1626 0.1616
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0014 0.0007
Echinococcus multilocularis regulator of G protein signaling 3 0.0108 0.025 0.025
Onchocerca volvulus 0.004 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.1638 0.5342 0.534
Schistosoma mansoni serine/threonine protein kinase 0.068 0.2154 0.2145
Trichomonas vaginalis cyclins, putative 0.0038 0.0018 0.0024
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0191 0.0527 0.0527
Entamoeba histolytica hypothetical protein, conserved 0.0077 0.0147 0.0226
Trypanosoma cruzi synaptotagmin, putative 0.0077 0.0147 0.0567
Schistosoma mansoni vav2 0.0508 0.1583 0.1573
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0038 0.0018 0.0018
Schistosoma mansoni rabphilin-3a 0.0077 0.0147 0.0135
Echinococcus granulosus G protein coupled receptor kinase 1 0.0191 0.0527 0.0527
Brugia malayi A-kinase anchor protein 10, precursor 0.0108 0.025 0.0247
Trichomonas vaginalis synaptotagmin, putative 0.0077 0.0147 0.0544
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0012 0.0025
Echinococcus multilocularis raf serine:threonine protein kinase 0.0496 0.154 0.154
Entamoeba histolytica diacylglycerol kinase, putative 0.0494 0.1537 0.2564
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Echinococcus multilocularis synaptotagmin 2 0.0077 0.0147 0.0147
Brugia malayi Cyclin, N-terminal domain containing protein 0.0038 0.0018 0.0014
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.078 0.2487 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Trichomonas vaginalis cyclin D, putative 0.0038 0.0018 0.0024
Echinococcus granulosus tyrosine protein kinase Src42A 0.0037 0.0016 0.0016
Brugia malayi C2 domain containing protein 0.0077 0.0147 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Brugia malayi calpain 5 0.0077 0.0147 0.0143
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Echinococcus granulosus cyclins 0.0038 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.2318 0.7605 0.7604
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0571 0.1792 0.1789
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Brugia malayi LD23056p 0.0077 0.0147 0.0143
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Schistosoma mansoni z-protein (S1r protein) 0.0108 0.025 0.0238
Loa Loa (eye worm) Nedd4-PD 0.0077 0.0147 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Echinococcus granulosus tyrosine protein kinase Lyn 0.0064 0.0104 0.0104
Entamoeba histolytica calcium-binding protein, putative 0.0077 0.0147 0.0226
Echinococcus granulosus copine 9 0.0077 0.0147 0.0147
Echinococcus granulosus synaptotagmin 0.0077 0.0147 0.0147
Brugia malayi C2 domain containing protein 0.0077 0.0147 0.0143
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0037 0.0014 0.0032
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0498 0.1549 0.1539
Echinococcus granulosus cyclins 0.0038 0.0018 0.0018
Entamoeba histolytica protein kinase, putative 0.0103 0.0235 0.0375
Echinococcus granulosus tyrosine protein kinase Blk 0.0034 0.0003 0.0003
Leishmania major hypothetical protein, conserved 0.0077 0.0147 0.0567
Entamoeba histolytica cyclin family protein 0.0038 0.0018 0.001
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0012 0.0009
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0077 0.0147 0.0135
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0498 0.1549 0.1549
Trichomonas vaginalis copine, putative 0.0077 0.0147 0.0544
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0077 0.0147 0.0567
Echinococcus multilocularis serine threonine protein kinase 0.2145 0.7029 0.7029
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0713 0.2266 0.2263
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0014 0.0007
Schistosoma mansoni glutaminase 0.0274 0.0804 0.0793
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.068 0.2154 0.2154
Echinococcus multilocularis synaptotagmin protein 4 0.0077 0.0147 0.0147
Schistosoma mansoni otoferlin 0.0077 0.0147 0.0135
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0077 0.0147 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Schistosoma mansoni hypothetical protein 0.0077 0.0147 0.0135
Schistosoma mansoni fer-1-related 0.0077 0.0147 0.0135
Schistosoma mansoni synaptotagmin 0.0077 0.0147 0.0135
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0077 0.0147 0.0147
Schistosoma mansoni synaptotagmin 0.0077 0.0147 0.0135
Leishmania major hypothetical protein, conserved 0.0077 0.0147 0.0567
Brugia malayi C2 domain containing protein 0.0077 0.0147 0.0143
Schistosoma mansoni unc-13 (munc13) 0.0077 0.0147 0.0135
Entamoeba histolytica C2 domain containing protein 0.0077 0.0147 0.0226
Entamoeba histolytica protein kinase, putative 0.068 0.2154 0.3602
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0077 0.0147 0.0147
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.068 0.2154 0.2151
Echinococcus multilocularis copine 9 0.0077 0.0147 0.0147
Echinococcus multilocularis cyclins 0.0038 0.0018 0.0018
Trichomonas vaginalis copine, putative 0.0077 0.0147 0.0544
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.025 0.0961
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0077 0.0147 0.0567
Echinococcus granulosus regulator of G protein signaling 3 0.0108 0.025 0.025
Schistosoma mansoni serine/threonine protein kinase 0.078 0.2487 0.2478
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.078 0.2487 1
Brugia malayi Variant SH3 domain containing protein 0.0091 0.0193 0.0189
Echinococcus multilocularis regulator of G protein signaling 7 0.0108 0.025 0.025
Leishmania major protein kinase A catalytic subunit 0.078 0.2487 1
Toxoplasma gondii AGC kinase 0.078 0.2487 1
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0207 0.0581 0.0578
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.3037 1 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0012 0.0012
Entamoeba histolytica protein kinase, putative 0.0103 0.0235 0.0375
Brugia malayi Cyclin, N-terminal domain containing protein 0.0038 0.0018 0.0014
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0483 0.1499 0.1496
Leishmania major protein kinase, putative 0.0037 0.0014 0.0032
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.078 0.2487 1
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.078 0.2487 0.2485
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Trypanosoma cruzi cyclin, putative 0.0038 0.0018 0.0049
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0014 0.0007
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.068 0.2154 0.2151
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.068 0.2154 0.2154
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0037 0.0014 0.0032
Brugia malayi Protein kinase domain containing protein 0.0521 0.1626 0.1623
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0018 0.0024
Schistosoma mansoni E3 ubiquitin-protein ligase nedd-4 0.0077 0.0147 0.0135
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0077 0.0147 0.0544
Plasmodium falciparum ferlin, putative 0.0077 0.0147 0.0567
Toxoplasma gondii hypothetical protein 0.0077 0.0147 0.0567
Echinococcus granulosus serine/threonine protein kinase 0.0037 0.0014 0.0014
Echinococcus granulosus unc 13 munc13 0.0571 0.1792 0.1792
Entamoeba histolytica protein kinase, putative 0.0037 0.0014 0.0003
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0016 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0147 0.0567
Schistosoma mansoni synaptotagmin 0.0077 0.0147 0.0135
Leishmania major protein kinase A catalytic subunit isoform 2 0.078 0.2487 1
Echinococcus granulosus Diacylglycerol kinase theta 0.0494 0.1537 0.1537
Schistosoma mansoni serine/threonine-protein kinase 0.0037 0.0014 0.0002
Brugia malayi protein kinase C3,putative 0.07 0.2222 0.2219
Leishmania major hypothetical protein, conserved 0.0077 0.0147 0.0567
Trichomonas vaginalis synaptotagmin, putative 0.0077 0.0147 0.0544
Entamoeba histolytica hypothetical protein 0.0037 0.0014 0.0003
Plasmodium falciparum calcium-dependent protein kinase 7 0.0037 0.0014 0.0032
Trichomonas vaginalis cyclins, putative 0.0038 0.0018 0.0024
Loa Loa (eye worm) glutaminase 2 0.0274 0.0804 0.0801
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0483 0.1499 0.1499
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0077 0.0147 0.0147
Brugia malayi C2 domain containing protein 0.0077 0.0147 0.0143
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.068 0.2154 0.2154
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.025 0.0961
Entamoeba histolytica C2 domain containing protein 0.0077 0.0147 0.0226
Onchocerca volvulus 0.0077 0.0147 0.0242
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0147 0.0567
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0037 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Schistosoma mansoni serine/threonine protein kinase 0.2639 0.8675 0.8673
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0037 0.0016 0.0016
Echinococcus multilocularis cyclins 0.0038 0.0018 0.0018
Trichomonas vaginalis cyclin A, putative 0.0038 0.0018 0.0024
Brugia malayi Ras association domain family 1 isoform A 0.0494 0.1537 0.1534
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Entamoeba histolytica C2 domain containing protein 0.0077 0.0147 0.0226
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0077 0.0147 0.0567
Echinococcus granulosus calpain 5 0.0077 0.0147 0.0147
Entamoeba histolytica C2 domain containing protein 0.0077 0.0147 0.0226
Loa Loa (eye worm) glutaminase 0.0274 0.0804 0.0801
Loa Loa (eye worm) AGC/PKN protein kinase 0.068 0.2154 0.2151
Toxoplasma gondii diacylglycerol kinase, putative 0.0494 0.1537 0.6171
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0014 0.0007
Entamoeba histolytica p21-activated kinase 0.0037 0.0014 0.0003
Trichomonas vaginalis copine, putative 0.0077 0.0147 0.0544
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0037 0.0016 0.0016
Echinococcus multilocularis protein piccolo 0.0077 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0494 0.1537 0.1534
Loa Loa (eye worm) hypothetical protein 0.0494 0.1537 0.1534
Entamoeba histolytica PH domain containing protein kinase, putative 0.0037 0.0014 0.0003
Onchocerca volvulus 0.0077 0.0147 0.0242
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.004 0.0024 0.002
Loa Loa (eye worm) C2 domain-containing protein 0.0077 0.0147 0.0143
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0147 0.0567
Onchocerca volvulus 0.1638 0.5342 1
Schistosoma mansoni hypothetical protein 0.0077 0.0147 0.0135
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0077 0.0147 0.0147
Trypanosoma brucei predicted C2 domain protein 0.0077 0.0147 0.0567
Brugia malayi RhoGAP domain containing protein 0.0494 0.1537 0.1534
Trypanosoma cruzi synaptotagmin, putative 0.0077 0.0147 0.0567
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0077 0.0147 0.0135
Echinococcus granulosus neural cell expressed developmentally 0.0077 0.0147 0.0147
Echinococcus granulosus axis inhibition protein axin 0.0108 0.025 0.025
Schistosoma mansoni Mername-AA248 (C02 family) 0.0077 0.0147 0.0135
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0006 0.0002
Trichomonas vaginalis cyclin B, putative 0.0038 0.0018 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Echinococcus multilocularis myotubularin protein 13 0.0505 0.1571 0.1571
Schistosoma mansoni synaptotagmin-like protein 0.0077 0.0147 0.0135
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0702 0.2227 0.2224
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.025 0.0961
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.068 0.2154 0.2154
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0012 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.025 0.0961
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0037 0.0014 0.0007
Echinococcus granulosus axis inhibition protein axin 0.0108 0.025 0.025
Trichomonas vaginalis cyclin D, putative 0.0038 0.0018 0.0024
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.0435 0.0432
Echinococcus granulosus UNCoordinated family member unc 13 0.0077 0.0147 0.0147
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0483 0.1499 0.1499
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0494 0.1537 0.1534
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Schistosoma mansoni synaptotagmin 12 0.0077 0.0147 0.0135
Loa Loa (eye worm) hypothetical protein 0.1638 0.5342 0.534
Entamoeba histolytica C2 domain containing protein 0.0077 0.0147 0.0226
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0038 0.0018 0.0049
Plasmodium vivax ferlin, putative 0.0077 0.0147 0.0567
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Echinococcus granulosus beta-adrenergic receptor kinase 0.0299 0.0886 0.0886
Onchocerca volvulus 0.0077 0.0147 0.0242
Trypanosoma brucei mitotic cyclin 6 0.0038 0.0018 0.0049
Echinococcus granulosus cyclin b3 0.0038 0.0018 0.0018
Brugia malayi Protein kinase domain containing protein 0.068 0.2154 0.2151
Leishmania major hypothetical protein, conserved 0.0082 0.0163 0.0632
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0077 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0685 0.2172 0.217
Loa Loa (eye worm) hypothetical protein 0.0038 0.0018 0.0014
Echinococcus granulosus otoferlin 0.0077 0.0147 0.0147
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.078 0.2487 1
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0014 0.0007
Entamoeba histolytica PH domain containing protein kinase, putative 0.0037 0.0014 0.0003
Echinococcus multilocularis axis inhibition protein axin 0.0108 0.025 0.025
Brugia malayi NEDD4.2 0.0077 0.0147 0.0143
Schistosoma mansoni serine/threonine protein kinase 0.0521 0.1626 0.1616
Echinococcus multilocularis synaptotagmin 0.0077 0.0147 0.0147
Entamoeba histolytica DENN domain protein 0.0077 0.0147 0.0226
Brugia malayi diacylglycerol kinase 0.0494 0.1537 0.1534
Loa Loa (eye worm) hypothetical protein 0.0108 0.025 0.0247
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0102 0.009
Schistosoma mansoni serine/threonine protein kinase 0.078 0.2487 0.2478
Trichomonas vaginalis copine, putative 0.0077 0.0147 0.0544
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0591 0.1858 0.1855
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0483 0.1499 0.1496
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0147 0.0567
Schistosoma mansoni protein kinase C 0.0571 0.1792 0.1782
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0014 0.0007
Echinococcus multilocularis cyclins 0.0038 0.0018 0.0018
Brugia malayi C2 domain containing protein 0.0077 0.0147 0.0143
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0038 0.0018 0.0018
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.0435 0.0435
Schistosoma mansoni hypothetical protein 0.0077 0.0147 0.0135
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0571 0.1792 0.1792
Echinococcus multilocularis regulator of G protein signaling 0.0108 0.025 0.025
Schistosoma mansoni serine/threonine protein kinase 0.068 0.2154 0.2145
Schistosoma mansoni synaptotagmin 0.0077 0.0147 0.0135
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0521 0.1626 0.1626
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0037 0.0016 0.0016
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0014 0.0007
Echinococcus multilocularis axis inhibition protein axin 0.0108 0.025 0.025
Loa Loa (eye worm) RGS-3 protein 0.0108 0.025 0.0247
Mycobacterium ulcerans glutaminase 0.0274 0.0804 1
Trichomonas vaginalis cyclin B, putative 0.0038 0.0018 0.0024
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0077 0.0147 0.0567
Brugia malayi C2 domain containing protein 0.0077 0.0147 0.0143
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0494 0.1537 0.1534
Trypanosoma brucei C2 domain containing protein, putative 0.0077 0.0147 0.0567
Brugia malayi Pleckstrin Homology Domain 0.0505 0.1571 0.1568
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.078 0.2487 1
Loa Loa (eye worm) AGC/PKA protein kinase 0.078 0.2487 0.2485
Leishmania major hypothetical protein, conserved 0.0077 0.0147 0.0567
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Echinococcus granulosus Rac GTPase activating protein 1 0.0494 0.1537 0.1537
Leishmania major copine i-like protein 0.0077 0.0147 0.0567
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Loa Loa (eye worm) hypothetical protein 0.0494 0.1537 0.1534
Entamoeba histolytica hypothetical protein 0.0077 0.0147 0.0226
Trichomonas vaginalis synaptotagmin, putative 0.0077 0.0147 0.0544
Entamoeba histolytica protein kinase, putative 0.0037 0.0014 0.0003
Onchocerca volvulus Putative cc2d1b protein 0.0077 0.0147 0.0242
Brugia malayi C2 domain containing protein 0.0077 0.0147 0.0143
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Echinococcus granulosus cGMP dependent protein kinase 1 0.0063 0.0102 0.0102
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0037 0.0014 0.0032
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0077 0.0147 0.0544
Schistosoma mansoni regulator of G protein signaling 0.0108 0.025 0.0238
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0012 0.0012
Echinococcus granulosus tyrosine protein kinase Src64B 0.0037 0.0016 0.0016
Schistosoma mansoni rho gtpase activating protein 0.0077 0.0147 0.0135
Entamoeba histolytica C2 domain containing protein 0.0077 0.0147 0.0226
Brugia malayi regulator of G-protein signaling egl-10 0.0108 0.025 0.0247
Loa Loa (eye worm) AGC/AKT protein kinase 0.069 0.2188 0.2185
Echinococcus granulosus synaptotagmin 2 0.0077 0.0147 0.0147
Schistosoma mansoni serine/threonine protein kinase 0.2639 0.8675 0.8673
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0147 0.0567
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0037 0.0014 0.0032
Entamoeba histolytica hypothetical protein 0.0077 0.0147 0.0226
Brugia malayi Augmenter of liver regeneration 0.0034 0.0006 0.0002
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0037 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.2132 0.6988 0.6987
Echinococcus granulosus myotubularin protein 13 0.0505 0.1571 0.1571
Echinococcus multilocularis cyclin B 0.0038 0.0018 0.0018
Leishmania major hypothetical protein, conserved 0.0077 0.0147 0.0567
Echinococcus multilocularis synaptotagmin 0.0077 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0494 0.1537 0.1534
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0037 0.0014 0.0032
Schistosoma mansoni diacylglycerol kinase theta 0.0494 0.1537 0.1527
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0077 0.0147 0.0147
Loa Loa (eye worm) RasGEF domain-containing protein 0.0494 0.1537 0.1534
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0108 0.025 0.0961
Entamoeba histolytica cyclin, putative 0.0038 0.0018 0.001
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0108 0.025 0.0247
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0571 0.1792 0.1792
Entamoeba histolytica cyclin family protein 0.0038 0.0018 0.001
Trichomonas vaginalis calcium-dependent lipid-binding protein, putative 0.0077 0.0147 0.0544
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0014 0.0007
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Schistosoma mansoni serine/threonine protein kinase 0.068 0.2154 0.2145
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0014 0.0007
Trypanosoma brucei synaptotagmin, putative 0.0077 0.0147 0.0567
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.068 0.2154 0.2151
Echinococcus granulosus cGMP dependent protein kinase 0.0063 0.0102 0.0102
Echinococcus multilocularis cyclin B3 1 0.0038 0.0018 0.0018
Schistosoma mansoni axis inhibition protein axin 0.0108 0.025 0.0238
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0037 0.0014 0.0032
Echinococcus multilocularis tyrosine protein kinase Srms 0.0034 0.0003 0.0003
Trypanosoma brucei rac serine-threonine kinase, putative 0.069 0.2188 0.8793
Echinococcus multilocularis Rac GTPase activating protein 1 0.0494 0.1537 0.1537
Brugia malayi Protein kinase domain containing protein 0.069 0.2188 0.2185
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0077 0.0147 0.0143
Echinococcus granulosus protein kinase C gamma type 0.2145 0.7029 0.7029
Entamoeba histolytica hypothetical protein 0.0077 0.0147 0.0226
Brugia malayi hypothetical protein 0.0108 0.025 0.0247
Trichomonas vaginalis AGC family protein kinase 0.069 0.2188 0.879
Echinococcus granulosus RNA directed DNA polymerase 0.1388 0.4511 0.4511
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0077 0.0147 0.0147
Trichomonas vaginalis AGC family protein kinase 0.069 0.2188 0.879
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0299 0.0886 0.0882
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Onchocerca volvulus 0.0077 0.0147 0.0242
Loa Loa (eye worm) hypothetical protein 0.0675 0.2139 0.2136
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0012 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0012 0.0025
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.078 0.2487 1
Trichomonas vaginalis AGC family protein kinase 0.069 0.2188 0.879
Brugia malayi C2 domain containing protein 0.0077 0.0147 0.0143
Loa Loa (eye worm) hypothetical protein 0.0494 0.1537 0.1534
Entamoeba histolytica protein kinase, putative 0.0037 0.0014 0.0003
Trichomonas vaginalis AGC family protein kinase 0.069 0.2188 0.879
Brugia malayi RhoGAP domain containing protein 0.0498 0.1549 0.1546
Trichomonas vaginalis synaptotagmin, putative 0.0077 0.0147 0.0544
Trichomonas vaginalis AGC family protein kinase 0.068 0.2154 0.8654
Brugia malayi regulator of G-protein signaling rgs-7 0.0108 0.025 0.0247
Entamoeba histolytica PH domain containing protein kinase, putative 0.079 0.2521 0.4219
Echinococcus granulosus active breakpoint cluster region 0.0077 0.0147 0.0147
Brugia malayi Regulator of G protein signaling domain containing protein 0.0108 0.025 0.0247
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0012 0.0025
Loa Loa (eye worm) hypothetical protein 0.078 0.2487 0.2485
Trichomonas vaginalis cyclin B3, putative 0.0038 0.0018 0.0024
Entamoeba histolytica C2 domain containing protein 0.0077 0.0147 0.0226
Brugia malayi Synaptotagmin protein 3 0.0077 0.0147 0.0143
Entamoeba histolytica PH domain containing protein kinase, putative 0.0037 0.0014 0.0003
Schistosoma mansoni glut4 vesicle protein-related 0.0077 0.0147 0.0135
Schistosoma mansoni serine/threonine protein kinase 0.0299 0.0886 0.0875
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0077 0.0147 0.0135
Trichomonas vaginalis splicing factor 3A subunit, putative 0.0077 0.0147 0.0544
Leishmania major cyclin 0.0038 0.0018 0.0049
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0498 0.1549 0.1546
Entamoeba histolytica hypothetical protein 0.0108 0.025 0.04
Loa Loa (eye worm) SRC-1 0.0037 0.0016 0.0012
Onchocerca volvulus 0.0685 0.2172 0.4047
Schistosoma mansoni synaptotagmin 0.0077 0.0147 0.0135
Echinococcus granulosus NEDD4 E3 ubiquitin protein ligase WWP1 0.0077 0.0147 0.0147
Onchocerca volvulus 0.0181 0.0493 0.0892
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Schistosoma mansoni protein kinase C mu 0.0494 0.1537 0.1527
Entamoeba histolytica protein kinase, putative 0.0037 0.0014 0.0003
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0037 0.0014 0.0032
Leishmania major hypothetical protein, conserved 0.0077 0.0147 0.0567
Entamoeba histolytica C2 domain containing protein 0.0077 0.0147 0.0226
Leishmania major c2 domain protein, putative 0.0077 0.0147 0.0567
Loa Loa (eye worm) hypothetical protein 0.0181 0.0493 0.049
Schistosoma mansoni tyrosine kinase 0.0037 0.0016 0.0004
Entamoeba histolytica PH domain containing protein kinase, putative 0.1823 0.5959 1
Schistosoma mansoni atypical protein kinase C 0.1367 0.444 0.4433
Echinococcus multilocularis microtubule associated protein 2 0.0692 0.2196 0.2196
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0037 0.0014 0.0032
Trypanosoma cruzi cAMP binding protein, putative 0.0082 0.0163 0.0632
Schistosoma mansoni cyclin B 0.0038 0.0018 0.0006
Echinococcus granulosus intersectin 2 0.008 0.0159 0.0159
Leishmania major phospholipase c-like protein 0.0077 0.0147 0.0567
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0077 0.0147 0.0143
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0498 0.1549 0.1549
Trypanosoma cruzi cyclin 6, putative 0.0038 0.0018 0.0049
Echinococcus multilocularis cyclins 0.0038 0.0018 0.0018
Trypanosoma brucei Coiled-coil and C2 domain-containing protein 0.0077 0.0147 0.0567
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0147 0.0567
Toxoplasma gondii AGC kinase 0.078 0.2487 1
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0077 0.0147 0.0544
Brugia malayi Hr1 repeat family protein 0.068 0.2154 0.2151
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.1491 0.4855 0.4853
Echinococcus multilocularis serine:threonine protein kinase 38 0.068 0.2154 0.2154
Trypanosoma brucei cAMP binding protein, putative 0.0082 0.0163 0.0632
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.0147 0.0143
Brugia malayi C1-like domain containing protein 0.0702 0.2227 0.2224
Schistosoma mansoni diacylglycerol kinase theta 0.0494 0.1537 0.1527
Loa Loa (eye worm) hypothetical protein 0.1388 0.4511 0.4509
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0037 0.0014 0.0032
Loa Loa (eye worm) AGC/PKG protein kinase 0.0063 0.0102 0.0098
Echinococcus multilocularis cyclins 0.0038 0.0018 0.0018
Trypanosoma brucei C2 domain containing protein, putative 0.0077 0.0147 0.0567
Loa Loa (eye worm) C2 domain-containing protein 0.0077 0.0147 0.0143
Echinococcus multilocularis copine 9 0.0077 0.0147 0.0147
Entamoeba histolytica hypothetical protein 0.0077 0.0147 0.0226
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0077 0.0147 0.0147
Brugia malayi Egg laying defective protein 4 0.0063 0.0102 0.0098
Toxoplasma gondii protein kinase domain-containing protein 0.0037 0.0014 0.0032
Schistosoma mansoni unc-13 (munc13) 0.0571 0.1792 0.1782
Echinococcus multilocularis Protein kinase C, brain isozyme 0.2639 0.8675 0.8675
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0147 0.0567
Trypanosoma brucei predicted C2 domain protein 0.0077 0.0147 0.0567
Echinococcus granulosus protein kinase c epsilon type 0.3037 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.025 0.0961
Brugia malayi C2 domain containing protein 0.0077 0.0147 0.0143
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0037 0.0014 0.0032
Plasmodium vivax ferlin, putative 0.0077 0.0147 0.0567
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0037 0.0014 0.0032
Loa Loa (eye worm) AGC/PKA protein kinase 0.078 0.2487 0.2485
Echinococcus granulosus extended synaptotagmin 2 0.0077 0.0147 0.0147
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0037 0.0014 0.0032
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0077 0.0147 0.0147
Schistosoma mansoni serine/threonine protein kinase 0.068 0.2154 0.2145
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0077 0.0147 0.0544
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Leishmania major protein kinase A catalytic subunit isoform 1 0.078 0.2487 1
Plasmodium falciparum cyclin 0.0038 0.0018 0.0049
Toxoplasma gondii Sma protein 0.0077 0.0147 0.0567
Trichomonas vaginalis cyclins, putative 0.0038 0.0018 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0591 0.1858 0.1848
Trichomonas vaginalis AGC family protein kinase 0.068 0.2154 0.8654
Toxoplasma gondii AGC kinase 0.068 0.2154 0.8657
Brugia malayi Protein kinase domain containing protein 0.068 0.2154 0.2151
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0077 0.0147 0.0147
Echinococcus granulosus synaptotagmin 0.0077 0.0147 0.0147
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.078 0.2487 0.2487
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.078 0.2487 0.2487
Brugia malayi C2 domain containing protein 0.0077 0.0147 0.0143
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0077 0.0147 0.0135
Echinococcus granulosus cyclin B 0.0038 0.0018 0.0018
Schistosoma mansoni alpha-glucosidase 0.0141 0.036 0.0348
Schistosoma mansoni hypothetical protein 0.0077 0.0147 0.0135
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0014 0.0007
Loa Loa (eye worm) C2 domain-containing protein 0.0077 0.0147 0.0143
Schistosoma mansoni cyclin B3 0.0038 0.0018 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Echinococcus multilocularis NEDD4 E3 ubiquitin protein ligase WWP1 0.0077 0.0147 0.0147
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0753 0.2399 0.2399
Trichomonas vaginalis cyclins, putative 0.0038 0.0018 0.0024
Plasmodium falciparum double C2-like domain-containing protein 0.0077 0.0147 0.0567
Entamoeba histolytica cyclin, putative 0.0038 0.0018 0.001
Echinococcus granulosus synaptotagmin 0.0077 0.0147 0.0147
Brugia malayi C2 domain containing protein 0.0077 0.0147 0.0143
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0077 0.0147 0.0567
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0014 0.0007
Brugia malayi phospholipase C homolog 0.0077 0.0147 0.0143
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0037 0.0016 0.0016
Trypanosoma brucei C2 domain containing protein, putative 0.0077 0.0147 0.0567
Trypanosoma cruzi Protein kinase B 0.0037 0.0014 0.0032
Echinococcus multilocularis intersectin 2 0.008 0.0159 0.0159
Entamoeba histolytica hypothetical protein, conserved 0.0077 0.0147 0.0226
Loa Loa (eye worm) hypothetical protein 0.0108 0.025 0.0247
Trypanosoma brucei C2 domain containing protein, putative 0.0077 0.0147 0.0567
Trichomonas vaginalis glutaminase, putative 0.0274 0.0804 0.32
Echinococcus multilocularis expressed conserved protein 0.0063 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0063 0.0102 0.0387
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0077 0.0147 0.0544
Echinococcus multilocularis extended synaptotagmin 2 0.0077 0.0147 0.0147
Brugia malayi SRC-1 0.0037 0.0016 0.0012
Echinococcus multilocularis expressed protein 0.0108 0.025 0.025
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0091 0.0193 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Loa Loa (eye worm) C2 domain-containing protein 0.0077 0.0147 0.0143
Leishmania major protein kinase, putative 0.0037 0.0014 0.0032
Toxoplasma gondii C2 domain-containing protein 0.0077 0.0147 0.0567
Schistosoma mansoni axis inhibition protein axin 0.0108 0.025 0.0238
Loa Loa (eye worm) AGC/NDR protein kinase 0.068 0.2154 0.2151
Loa Loa (eye worm) hypothetical protein 0.1638 0.5342 0.534
Trichomonas vaginalis AGC family protein kinase 0.078 0.2487 1
Brugia malayi PXA domain containing protein 0.0108 0.025 0.0247
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.0016 0.0016
Echinococcus granulosus synaptotagmin protein 4 0.0077 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.1883 0.6157 0.6156
Entamoeba histolytica C2 domain protein, putative 0.0077 0.0147 0.0226
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0034 0.0003 0.0003
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.068 0.2154 0.2151
Brugia malayi Copine VIII 0.0077 0.0147 0.0143
Onchocerca volvulus 0.0675 0.2139 0.3983
Loa Loa (eye worm) synaptotagmin-1 0.0077 0.0147 0.0143
Echinococcus multilocularis 0.0077 0.0147 0.0147
Entamoeba histolytica protein kinase, putative 0.0037 0.0014 0.0003
Onchocerca volvulus Multiple C2 domain and transmembrane region protein homolog 0.0077 0.0147 0.0242
Echinococcus multilocularis active breakpoint cluster region 0.0077 0.0147 0.0147
Trypanosoma cruzi CYC2-like cyclin, putative 0.0038 0.0018 0.0049
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0108 0.025 0.025
Brugia malayi Regulator of G protein signaling domain containing protein 0.0108 0.025 0.0247
Schistosoma mansoni serine/threonine protein kinase 0.3037 1 1
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.078 0.2487 1
Loa Loa (eye worm) copine family protein 0.0077 0.0147 0.0143
Echinococcus granulosus cyclins 0.0038 0.0018 0.0018
Echinococcus granulosus copine 9 0.0077 0.0147 0.0147
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0147 0.0567
Echinococcus multilocularis cyclins 0.0038 0.0018 0.0018
Schistosoma mansoni microtubule-associated protein tau 0.0692 0.2196 0.2186
Leishmania major folate/biopterin transporter, putative 0.0037 0.0014 0.0032
Leishmania major serine/threonine-protein kinase a, putative 0.0037 0.0014 0.0032
Echinococcus granulosus myoferlin 0.0077 0.0147 0.0147
Brugia malayi Protein kinase c protein 2 0.1986 0.6501 0.65
Echinococcus granulosus expressed protein 0.0108 0.025 0.025
Entamoeba histolytica diacylglycerol kinase, putative 0.0494 0.1537 0.2564
Loa Loa (eye worm) C2 domain-containing protein 0.0077 0.0147 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.025 0.0961
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Trypanosoma brucei C2 domain/Ankyrin repeats (3 copies), putative 0.0077 0.0147 0.0567
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0014 0.0007
Brugia malayi Synaptotagmin I 0.0077 0.0147 0.0143
Brugia malayi C2 domain containing protein 0.0077 0.0147 0.0143
Echinococcus multilocularis serine:threonine protein kinase N2 0.2466 0.8099 0.8099
Echinococcus granulosus serine:threonine protein kinase N2 0.1813 0.5925 0.5925
Trichomonas vaginalis AGC family protein kinase 0.069 0.2188 0.879
Loa Loa (eye worm) hypothetical protein 0.0038 0.0018 0.0014
Entamoeba histolytica protein kinase, putative 0.068 0.2154 0.3602
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0063 0.0102 0.0102
Entamoeba histolytica protein kinase, putative 0.069 0.2188 0.3659
Echinococcus multilocularis Diacylglycerol kinase theta 0.0494 0.1537 0.1537
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0077 0.0147 0.0567
Entamoeba histolytica hypothetical protein 0.0037 0.0014 0.0003
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0653 0.2065 0.8296
Echinococcus multilocularis neural cell expressed, developmentally 0.0077 0.0147 0.0147
Schistosoma mansoni mctp-related 0.0077 0.0147 0.0135
Loa Loa (eye worm) hypothetical protein 0.0494 0.1537 0.1534
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0435 0.0435
Echinococcus granulosus regulator of G protein signaling 7 0.0108 0.025 0.025
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.078 0.2487 0.2487
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0521 0.1626 0.1626
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Echinococcus granulosus NDR protein kinase 0.068 0.2154 0.2154
Schistosoma mansoni serine/threonine protein kinase 0.078 0.2487 0.2478
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Echinococcus granulosus regulator of G protein signaling 7 0.0108 0.025 0.025
Schistosoma mansoni hypothetical protein 0.0494 0.1537 0.1527
Plasmodium falciparum ferlin, putative 0.0077 0.0147 0.0567
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0077 0.0147 0.0544
Entamoeba histolytica C2 domain containing protein 0.0077 0.0147 0.0226
Entamoeba histolytica hypothetical protein 0.0494 0.1537 0.2564
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.068 0.2154 0.2154
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.078 0.2487 0.2487
Echinococcus granulosus microtubule associated protein 2 0.0692 0.2196 0.2196
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Echinococcus multilocularis N chimaerin 0.0498 0.1549 0.1549
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0108 0.025 0.0238
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.0435 0.0432
Echinococcus multilocularis rac serine:threonine kinase 0.0037 0.0014 0.0014
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0753 0.2399 0.2399
Echinococcus multilocularis unc 13 (munc13) 0.0571 0.1792 0.1792
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0037 0.0014 0.0032
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0077 0.0147 0.0143
Trypanosoma cruzi C2 domain/Ankyrin repeats (3 copies), putative 0.0077 0.0147 0.0567
Schistosoma mansoni alpha-glucosidase 0.0141 0.036 0.0348
Loa Loa (eye worm) hypothetical protein 0.0108 0.025 0.0247
Schistosoma mansoni regulator of G protein signaling 0.0108 0.025 0.0238
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0014 0.0007
Echinococcus multilocularis beta adrenergic receptor kinase 0.0299 0.0886 0.0886
Schistosoma mansoni synaptic ras gtpase activating protein syngap 0.0077 0.0147 0.0135
Echinococcus granulosus regulator of G protein signaling 3 0.0108 0.025 0.025
Echinococcus granulosus Protein kinase C brain isozyme 0.2639 0.8675 0.8675
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0037 0.0014 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0147 0.0567
Brugia malayi hypothetical protein 0.0108 0.025 0.0247
Trichomonas vaginalis ion channel nompc, putative 0.0077 0.0147 0.0544
Trichomonas vaginalis cyclin B, putative 0.0038 0.0018 0.0024
Echinococcus multilocularis cyclins 0.0038 0.0018 0.0018
Echinococcus granulosus protein kinase c iota type 0.1354 0.4396 0.4396
Entamoeba histolytica hypothetical protein 0.0077 0.0147 0.0226
Leishmania major c2 domain protein, putative 0.0077 0.0147 0.0567
Echinococcus multilocularis protein kinase c epsilon type 0.3037 1 1
Echinococcus granulosus tyrosine kinase 0.0034 0.0003 0.0003
Echinococcus multilocularis synaptotagmin 0.0077 0.0147 0.0147
Schistosoma mansoni rac gtpase activating protein 0.0494 0.1537 0.1527
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0147 0.0544
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.0016 0.0016
Trypanosoma brucei predicted C2 domain protein 0.0077 0.0147 0.0567
Trichomonas vaginalis AGC family protein kinase 0.069 0.2188 0.879
Loa Loa (eye worm) hypothetical protein 0.0077 0.0147 0.0143
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.078 0.2487 0.2487
Echinococcus granulosus cyclins 0.0038 0.0018 0.0018
Brugia malayi Copine family protein 0.0077 0.0147 0.0143
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.068 0.2154 0.2154
Onchocerca volvulus 0.0095 0.0206 0.0353
Schistosoma mansoni regulator of G protein signaling 0.0108 0.025 0.0238
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0077 0.0147 0.0147
Echinococcus multilocularis RNA directed DNA polymerase 0.1388 0.4511 0.4511
Echinococcus granulosus cGMP dependent protein kinase 1 0.0063 0.0102 0.0102
Loa Loa (eye worm) C2 domain-containing protein 0.0077 0.0147 0.0143
Trypanosoma cruzi NIMA-related kinase, putative 0.0037 0.0014 0.0032
Entamoeba histolytica hypothetical protein 0.0108 0.025 0.04
Trichomonas vaginalis annexin VII, putative 0.0077 0.0147 0.0544
Brugia malayi Variant SH3 domain containing protein 0.0498 0.1549 0.1546
Trichomonas vaginalis Circumsporozoite protein precursor, putative 0.0077 0.0147 0.0544

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 16 ug ml-1 Minimum inhibitory concentration to inhibit 90 to 100% visible growth of Candida albicans ChEMBL. 12565963
MIC (functional) = 16 ug ml-1 Minimum inhibitory concentration to inhibit 90 to 100% visible growth of Candida albicans ChEMBL. 12565963
MIC (functional) = 128 ug ml-1 Minimum inhibitory concentration required to inhibit 90 to 100% visible growth of Candida glabrata ChEMBL. 12565963

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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