Detailed information for compound 272622

Basic information

Technical information
  • TDR Targets ID: 272622
  • Name: 1-[4-[2-[(E)-2-(2-fluorophenyl)ethenyl]phenox y]butyl]-4-methylpiperazine
  • MW: 368.488 | Formula: C23H29FN2O
  • H donors: 0 H acceptors: 0 LogP: 4.83 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)CCCCOc1ccccc1/C=C/c1ccccc1F
  • InChi: 1S/C23H29FN2O/c1-25-15-17-26(18-16-25)14-6-7-19-27-23-11-5-3-9-21(23)13-12-20-8-2-4-10-22(20)24/h2-5,8-13H,6-7,14-19H2,1H3/b13-12+
  • InChiKey: HERCREJRFBCMAE-OUKQBFOZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[4-[2-[(E)-2-(2-fluorophenyl)vinyl]phenoxy]butyl]-4-methyl-piperazine
  • 1-[4-[2-[(E)-2-(2-fluorophenyl)vinyl]phenoxy]butyl]-4-methylpiperazine
  • 1-[4-[2-[(E)-2-(2-fluorophenyl)ethenyl]phenoxy]butyl]-4-methyl-piperazine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Patched family protein 0.0012 0.0004 0.0012
Echinococcus multilocularis Niemann Pick C1 protein 0.0195 0.0423 0.1134
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0033 0.0132
Echinococcus multilocularis segment polarity protein dishevelled 0.0018 0.0017 0.0047
Echinococcus granulosus thioredoxin glutathione reductase 0.0083 0.0168 0.0685
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0008 0.0008
Schistosoma mansoni coup transcription factor 0.0051 0.0094 0.0501
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0132
Schistosoma mansoni ras GTP exchange factor 0.0012 0.0006 0.0032
Brugia malayi follicle stimulating hormone receptor 0.0236 0.0516 0.2105
Onchocerca volvulus Dual oxidase homolog 0.0161 0.0344 0.1517
Leishmania major acetyl-CoA synthetase, putative 0.0065 0.0125 0.0909
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0171 0.2072
Brugia malayi Bromodomain containing protein 0.0082 0.0165 0.067
Toxoplasma gondii LsmAD domain-containing protein 0.0105 0.0216 0.2621
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0223 0.0598
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0188 0.0406 0.0415
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0611 0.137 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.022 0.0479 0.0459
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0188 0.0406 0.0415
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.0125 0.0104
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0011 0.0002 0.0008
Brugia malayi hypothetical protein 0.0027 0.0039 0.0154
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0033 0.0137
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.4153 0.945 1
Onchocerca volvulus 0.0065 0.0125 0.0546
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0082 0.0165 0.016
Trypanosoma cruzi phosphomannose isomerase, putative 0.0095 0.0194 0.1416
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0164 0.0352 0.0359
Leishmania major acetyl-CoA synthetase, putative 0.0065 0.0125 0.0909
Brugia malayi Patched family protein 0.0012 0.0004 0.0012
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0012 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.007
Brugia malayi Patched related family protein 12 0.0012 0.0004 0.0012
Schistosoma mansoni cellular tumor antigen P53 0.0106 0.022 0.1171
Trichomonas vaginalis rotamase, putative 0.0032 0.0051 0.0051
Brugia malayi Ubiquitin-like protein SMT3 0.003 0.0046 0.0183
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0085 0.0171 0.0458
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0065 0.0125 0.0909
Toxoplasma gondii thioredoxin reductase 0.0082 0.0165 0.2003
Entamoeba histolytica hypothetical protein 0.0177 0.0382 0.7238
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0384
Schistosoma mansoni inositol monophosphatase 0.0038 0.0064 0.034
Leishmania major importin beta-1 subunit, putative 0.005 0.0091 0.066
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0033 0.0133
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0223 0.0223
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0171 0.4142
Onchocerca volvulus 0.0065 0.0125 0.0546
Echinococcus multilocularis dnaJ subfamily B 0.0835 0.1881 0.504
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0023
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0177 0.0382 0.1562
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0065 0.0125 0.0314
Brugia malayi glutathione reductase 0.0082 0.0165 0.0669
Mycobacterium leprae Probable lipase LipE 0.0107 0.0222 0.0694
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0011 0.0002 0.0009
Echinococcus granulosus peroxidasin 0.0161 0.0344 0.1407
Loa Loa (eye worm) hypothetical protein 0.0107 0.0222 0.0907
Toxoplasma gondii patched family protein 0.0012 0.0004 0.0054
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0384
Onchocerca volvulus 0.0018 0.0017 0.007
Schistosoma mansoni bromodomain containing protein 0.0011 0.0003 0.0016
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.0313 0.1665
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0014 0.0037
Brugia malayi Patched family protein 0.0012 0.0004 0.0012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0155 0.0332 0.0337
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Trichomonas vaginalis ras GTP exchange factor, putative 0.0012 0.0006 0.0006
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0018 0.0017 0.0065
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.008 0.0971
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0104 0.0096
Echinococcus multilocularis Small ubiquitin modifier 2 0.003 0.0046 0.0124
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0132
Echinococcus multilocularis peroxidasin 0.0161 0.0344 0.0922
Echinococcus granulosus tumor protein p63 0.0727 0.1636 0.6692
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0005 0.0005
Onchocerca volvulus 0.0107 0.0222 0.0978
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0005 0.0005
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.008 0.0584
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0356 0.079 0.3494
Onchocerca volvulus 0.0024 0.0033 0.0137
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0241 0.0528 0.1884
Echinococcus granulosus hyperpolarization activated cyclic 0.0011 0.0002 0.0009
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0002 0.0012
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0033 0.0127
Trypanosoma brucei trypanothione reductase 0.0082 0.0165 0.1204
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.0222 0.0903
Trichomonas vaginalis ran, putative 0.0045 0.008 0.008
Echinococcus multilocularis 0.0012 0.0005 0.0014
Brugia malayi 6-phosphofructokinase 0.0108 0.0223 0.0908
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0371 0.0824 0.337
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0014 0.0098
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0209 0.0453 0.1595
Loa Loa (eye worm) beta-lactamase 0.0107 0.0222 0.0907
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0044 0.0533
Trichomonas vaginalis ubiquitin, putative 0.0011 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0008 0.0008
Loa Loa (eye worm) patched family protein 0.0012 0.0004 0.0017
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0033 0.0087
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0051 0.0094 0.0501
Trypanosoma brucei ISWI complex protein 0.0015 0.0013 0.009
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0002 0.0012
Onchocerca volvulus Peroxidasin homolog 0.0161 0.0344 0.1517
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0171 0.015
Loa Loa (eye worm) animal heme peroxidase 0.0161 0.0344 0.1404
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0039 0.0208
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0039 0.0105
Schistosoma mansoni carbonic anhydrase 0.0241 0.0528 0.2804
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0012 0.0006 0.0113
Loa Loa (eye worm) hypothetical protein 0.0045 0.0079 0.0322
Loa Loa (eye worm) hypothetical protein 0.0107 0.0222 0.0907
Plasmodium vivax sulfate transporter, putative 0.0159 0.0341 0.9668
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0044 0.0044
Brugia malayi Myosin head containing protein 0.0012 0.0004 0.0012
Brugia malayi Patched family protein 0.0012 0.0004 0.0012
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0042 0.0308
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0039 0.0154
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0371 0.0824 0.3367
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0223 0.1629
Trichomonas vaginalis dullard protein, putative 0.0012 0.0005 0.0005
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0042 0.0308
Loa Loa (eye worm) hypothetical protein 0.0065 0.0125 0.0509
Echinococcus multilocularis FTZ F1 alpha 0.0051 0.0094 0.0252
Brugia malayi DIX domain containing protein 0.0018 0.0017 0.0065
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0012 0.0006 0.0113
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0042 0.0308
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0248 0.1011
Brugia malayi Patched related family protein 10 0.0012 0.0004 0.0012
Echinococcus multilocularis importin subunit beta 1 0.0061 0.0117 0.0314
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0 0.0003
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0012 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0384
Echinococcus granulosus GPCR family 2 0.0048 0.0088 0.0358
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0065 0.0125 0.0118
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0012 0.0006 0.0113
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0014 0.0166
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0223 0.1187
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0044 0.1246
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0065 0.0125 0.0118
Loa Loa (eye worm) blistered cuticle protein 3 0.0161 0.0344 0.1404
Loa Loa (eye worm) RasGEF domain-containing protein 0.0012 0.0006 0.0023
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0177 0.0382 0.1023
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0017 0.0044
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0052 0.0095 0.0198
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0064 0.0043
Loa Loa (eye worm) hypothetical protein 0.0104 0.0215 0.0879
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0018 0.0017 0.0065
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0094 0.0501
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0196 0.0425 0.1737
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0011 0.0044
Toxoplasma gondii phosphomannose isomerase type I protein 0.0095 0.0194 0.2357
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0011 0.0002 0.0008
Schistosoma mansoni cpg binding protein 0.0064 0.0123 0.0655
Brugia malayi Steroid receptor seven-up type 2 0.0051 0.0094 0.0379
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0042 0.0515
Plasmodium vivax glutathione reductase, putative 0.0082 0.0165 0.4687
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0051 0.0094 0.0385
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0051 0.0094 0.0384
Loa Loa (eye worm) hypothetical protein 0.0039 0.0066 0.0267
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0002 0.0012
Plasmodium vivax thioredoxin reductase, putative 0.0082 0.0165 0.4687
Trichomonas vaginalis conserved hypothetical protein 0.4394 1 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0012 0.0006 0.0019
Brugia malayi Patched family protein 0.0012 0.0004 0.0012
Plasmodium vivax importin-beta 2, putative 0.0061 0.0117 0.3323
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0078
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0033 0.0087
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0222 0.0222
Echinococcus granulosus FTZ F1 alpha 0.0051 0.0094 0.0385
Plasmodium falciparum glutathione reductase 0.0029 0.0042 0.0515
Plasmodium falciparum transportin 0.0012 0.0004 0.0047
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0012 0.0006 0.0024
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0044 0.0077 0.1454
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0159 0.0341 0.4132
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0123 0.0651
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0132
Leishmania major 4-coumarate:coa ligase-like protein 0.022 0.0479 0.3496
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0051 0.0094 0.0252
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0095 0.0194 0.0173
Trichomonas vaginalis importin beta-1, putative 0.005 0.0091 0.0091
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.022 0.0479 0.0493
Trypanosoma cruzi PAB1-binding protein , putative 0.0105 0.0216 0.1575
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0033 0.0173
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0012 0.0006 0.0006
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0223 0.4234
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0042 0.0167
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.013 0.0349
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.0052 0.0095 0.0086
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Echinococcus granulosus Niemann Pick C1 protein 0.0279 0.0615 0.2513
Schistosoma mansoni carbonic anhydrase-related 0.0371 0.0824 0.4381
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0044 0.1251
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0065 0.0125 0.0104
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0017 0.0088
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0002 0.0006
Brugia malayi hypothetical protein 0.0012 0.0004 0.0012
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0064 0.3733
Brugia malayi Patched family protein 0.0012 0.0004 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0042 0.0308
Echinococcus multilocularis muscleblind protein 0.1082 0.2445 0.6551
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0052 0.0213
Entamoeba histolytica hypothetical protein 0.0011 0.0002 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0123 0.0651
Loa Loa (eye worm) DIX domain-containing protein 0.0018 0.0017 0.007
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0002 0.0006
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.0222 0.0595
Loa Loa (eye worm) importin-beta domain-containing protein 0.0012 0.0004 0.0014
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.0299 0.1221
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0105 0.0216 0.0882
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0021 0.0008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0132
Brugia malayi 6-phosphofructokinase 0.0108 0.0223 0.0908
Toxoplasma gondii hypothetical protein 0.0029 0.0044 0.0535
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0371 0.0824 0.3367
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.1154 0.2611 0.2752
Loa Loa (eye worm) glutathione reductase 0.0082 0.0165 0.0674
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0044 0.0044
Schistosoma mansoni transcription factor LCR-F1 0.0177 0.0382 0.203
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0095 0.0194 0.0789
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0064 0.0465
Brugia malayi ecdysone receptor 0.0024 0.0033 0.0127
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0021 0.0154
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0067 0.8292
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0012 0.0005 0.0065
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.0125 0.0104
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0195 0.0423 0.8021
Brugia malayi Blistered cuticle protein 3 0.0161 0.0344 0.14
Schistosoma mansoni inositol monophosphatase 0.0038 0.0064 0.034
Leishmania major phosphomannose isomerase 0.0095 0.0194 0.1416
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.008 0.0215
Loa Loa (eye worm) hypothetical protein 0.0161 0.0344 0.1404
Schistosoma mansoni hypothetical protein 0.0835 0.1881 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0171 0.2072
Plasmodium falciparum ataxin-2 like protein, putative 0.0105 0.0216 0.2621
Onchocerca volvulus 0.0107 0.0222 0.0978
Loa Loa (eye worm) patched family protein 0.0012 0.0004 0.0017
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0094 0.0501
Echinococcus multilocularis cpg binding protein 0.0064 0.0123 0.033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0008 0.0008
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0611 0.137 0.56
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0611 0.137 0.56
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0094 0.0379
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0044 0.0533
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0012 0.0005 0.0014
Entamoeba histolytica hypothetical protein 0.0177 0.0382 0.7238
Echinococcus granulosus tar DNA binding protein 0.0064 0.0123 0.0501
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0065 0.0125 0.0118
Echinococcus granulosus hyperpolarization activated cyclic 0.0011 0.0002 0.0009
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0065 0.0125 0.0314
Trypanosoma brucei small ubiquitin-related modifier 0.003 0.0046 0.0336
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0223 0.0222
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0014 0.0037
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0033 0.0132
Loa Loa (eye worm) hypothetical protein 0.0164 0.0352 0.1439
Echinococcus granulosus neuropeptide s receptor 0.0463 0.1034 0.4227
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.008 1
Echinococcus granulosus expressed conserved protein 0.0184 0.0396 0.162
Onchocerca volvulus Chorion peroxidase homolog 0.0161 0.0344 0.1517
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0065 0.0125 0.0909
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0023 0.0086
Toxoplasma gondii patched family protein 0.0012 0.0004 0.0054
Schistosoma mansoni peroxidasin 0.0161 0.0344 0.1828
Echinococcus multilocularis carbonic anhydrase 0.0371 0.0824 0.2208
Loa Loa (eye worm) oxidoreductase 0.0065 0.0125 0.0509
Brugia malayi hypothetical protein 0.0012 0.0004 0.0012
Echinococcus granulosus son of sevenless 1 0.0012 0.0006 0.0024
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.0222 0.0221
Loa Loa (eye worm) hypothetical protein 0.0164 0.0352 0.1439
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0132
Echinococcus granulosus muscleblind protein 0.1082 0.2445 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0012 0.0006 0.0113
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0065 0.0125 0.2364
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0248 0.1011
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0018 0.0017 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0051 0.0094 0.0384
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0095 0.0194 0.2357
Loa Loa (eye worm) hypothetical protein 0.0107 0.0222 0.0907
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0196 0.0425 0.1732
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0021 0.0259
Echinococcus multilocularis thyroid hormone receptor alpha 0.0051 0.0094 0.0252
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0085 0.0171 0.4849
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0039 0.0208
Loa Loa (eye worm) hypothetical protein 0.0161 0.0344 0.1404
Entamoeba histolytica acyl-CoA synthetase, putative 0.022 0.0479 0.9081
Loa Loa (eye worm) hypothetical protein 0.0027 0.0039 0.0159
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0017 0.0047
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0065 0.0125 0.0909
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0095 0.0194 0.0793
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0065 0.0125 0.0118
Brugia malayi Animal haem peroxidase family protein 0.0161 0.0344 0.14
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.0516 0.2109
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0056 0.0104 0.0096
Echinococcus multilocularis neuropeptide receptor A26 0.0463 0.1034 0.2769
Echinococcus granulosus translational activator gcn1 0.0012 0.0004 0.0016
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.008 0.0973
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0025 0.0097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.0425 0.2258
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0164 0.0352 0.1439
Onchocerca volvulus Protein patched homolog 0.0012 0.0004 0.0013
Brugia malayi nuclear hormone receptor 0.0051 0.0094 0.0379
Loa Loa (eye worm) hypothetical protein 0.0071 0.014 0.057
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0064 0.0465
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0065 0.0125 0.0104
Brugia malayi hypothetical protein 0.0018 0.0017 0.0065
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.0313 0.1276
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0018 0.0017 0.007
Loa Loa (eye worm) hypothetical protein 0.0161 0.0344 0.1404
Loa Loa (eye worm) SMO-1 protein 0.003 0.0046 0.0188
Loa Loa (eye worm) patched family protein 0.0012 0.0004 0.0017
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0104 0.0426
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0044 0.0044
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0064 0.0064
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0044 0.0045
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0044 0.1246
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0005 0.0028
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0039 0.016
Onchocerca volvulus 0.0024 0.0033 0.0137
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0065 0.0125 0.0909
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0042 0.0308
Mycobacterium leprae conserved hypothetical protein 0.0107 0.0222 0.0694
Brugia malayi ecdysteroid receptor 0.0051 0.0094 0.0379
Trypanosoma cruzi small ubiquitin protein, putative 0.003 0.0046 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0051 0.0094 0.0379
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0039 0.0159
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0104 0.0279
Brugia malayi Thioredoxin reductase 0.0082 0.0165 0.0669
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0014 0.0098
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0005 0.0005
Mycobacterium leprae Probable transmembrane transport protein 0.1154 0.2611 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0051 0.0094 0.0501
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.0125 0.0104
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0384
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0012 0.0006 0.0032
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0611 0.137 0.5602
Schistosoma mansoni zinc finger protein 0.0015 0.0013 0.0067
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0044 0.0533
Mycobacterium tuberculosis Probable reductase 0.0188 0.0406 0.0415
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0033 0.0087
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0021 0.2664
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.0125 0.0104
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0222 0.0222
Schistosoma mansoni carbonic anhydrase 0.0371 0.0824 0.4381
Schistosoma mansoni hypothetical protein 0.0654 0.1468 0.7803
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0164 0.0352 0.0332
Brugia malayi hypothetical protein 0.0024 0.0033 0.0127
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0033 0.0137
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0033 0.0127
Schistosoma mansoni hypothetical protein 0.0047 0.0084 0.0449
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0037 0.0151
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0012 0.0006 0.0032
Trichomonas vaginalis antibiotic synthetase, putative 0.0065 0.0125 0.0125
Schistosoma mansoni mannose-6-phosphate isomerase 0.0095 0.0194 0.1033
Onchocerca volvulus 0.0012 0.0006 0.0019
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0051 0.0368
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0065 0.0125 0.0314
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0051 0.0094 0.0252
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.008 0.008
Brugia malayi hypothetical protein 0.0161 0.0344 0.14
Brugia malayi nuclear receptor RXR 0.0024 0.0033 0.0127
Schistosoma mansoni acetyl-CoA synthetase 0.0065 0.0125 0.0663
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0042 0.0308
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0011 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Loa Loa (eye worm) carbonic anhydrase 3 0.0611 0.137 0.5602
Mycobacterium tuberculosis Probable oxidoreductase 0.0209 0.0453 0.0466
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0052 0.0208
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0123 0.0651
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0132
Echinococcus multilocularis ubiquitin 0.0011 0.0002 0.0004
Brugia malayi Probable ClpP-like protease 0.0085 0.0171 0.0693
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0021 0.0154
Schistosoma mansoni dishevelled 0.0018 0.0017 0.0093
Brugia malayi beta-lactamase family protein 0.0107 0.0222 0.0903
Echinococcus multilocularis translational activator gcn1 0.0012 0.0004 0.001
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0021 0.0021
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0064 0.0064
Loa Loa (eye worm) thioredoxin reductase 0.0082 0.0165 0.0674
Brugia malayi AMP-binding enzyme family protein 0.0065 0.0125 0.0504
Toxoplasma gondii patched family protein 0.0012 0.0004 0.0054
Schistosoma mansoni retinoic acid receptor RXR 0.0051 0.0094 0.0501
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0051 0.0094 0.0379
Echinococcus granulosus neuropeptide receptor A26 0.0463 0.1034 0.4227
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0051 0.0094 0.0252
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0123 0.0495
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0033 0.0133
Brugia malayi Patched family protein 0.0012 0.0004 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0094 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0008 0.0008
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.0004 0.0054
Echinococcus granulosus cpg binding protein 0.0064 0.0123 0.0504
Echinococcus multilocularis expressed conserved protein 0.0184 0.0396 0.1061
Onchocerca volvulus 0.0161 0.0344 0.1517
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0042 0.0308
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0008 0.0008
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0014 0.0098
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0051 0.0094 0.0385
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0123 0.05
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0065 0.0125 0.0909
Onchocerca volvulus 0.0107 0.0222 0.0978
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0012 0.0005 0.0015
Schistosoma mansoni hypothetical protein 0.0371 0.0824 0.4381
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.008 0.0322
Plasmodium vivax acyl-CoA synthetase, putative 0.0164 0.0352 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0042 0.0308
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0014 0.0037
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0011 0.0002 0.0009
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0012 0.0006 0.0113
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0005
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0002 0.0012
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.022 0.0479 0.0459
Echinococcus granulosus carbonic anhydrase 0.0371 0.0824 0.3371
Chlamydia trachomatis sulfate transporter 0.0159 0.0341 0.9622
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0215 0.0875
Entamoeba histolytica acyl-CoA synthetase, putative 0.022 0.0479 0.9081
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0159 0.0341 0.032
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0384
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0064 0.0064
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0159 0.0341 0.2484
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0042 0.1206
Loa Loa (eye worm) hypothetical protein 0.0107 0.0222 0.0907
Onchocerca volvulus 0.022 0.0479 0.2117
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.0222 0.0908
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0188 0.0406 0.0415
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0042 0.0021
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0042 0.0515
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0012 0.0004 0.0026
Trichomonas vaginalis antibiotic synthetase, putative 0.0065 0.0125 0.0125
Schistosoma mansoni zinc finger protein 0.0024 0.0033 0.0173
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.022 0.0479 0.1695
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0008 0.0008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0033 0.0087
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0065 0.0125 0.1513
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0064 0.0776
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0171 0.015
Echinococcus granulosus ras GTP exchange factor 0.0012 0.0006 0.0024
Schistosoma mansoni cpg binding protein 0.0064 0.0123 0.0655
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0123 0.0651
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.008 0.2272
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0064 0.0465
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0051 0.0094 0.0384
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0002 0.0009
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0033 0.0173
Leishmania major 4-coumarate:coa ligase-like protein 0.022 0.0479 0.3496
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Loa Loa (eye worm) inositol-1 0.0038 0.0064 0.026
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0196 0.0425 0.1736
Loa Loa (eye worm) hypothetical protein 0.1082 0.2445 1
Echinococcus granulosus CTD small phosphatase protein like 0.0012 0.0005 0.0022
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.002
Trichomonas vaginalis dullard protein, putative 0.0012 0.0005 0.0005
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0223 0.1187
Onchocerca volvulus 0.0012 0.0004 0.0013
Brugia malayi MH2 domain containing protein 0.0118 0.0248 0.1007
Entamoeba histolytica ubiquitin like protein 0.003 0.0046 0.0878
Echinococcus granulosus Pleckstrin G protein interacting region 0.0018 0.0017 0.0071
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0223 0.0223
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0042 0.0042
Echinococcus multilocularis importin 5 0.0012 0.0004 0.001
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0164 0.0352 1
Schistosoma mansoni ran 0.0045 0.008 0.0426
Loa Loa (eye worm) patched family protein 0.0012 0.0004 0.0017
Trichomonas vaginalis rotamase, putative 0.0033 0.0052 0.0052
Echinococcus granulosus Small ubiquitin modifier 2 0.003 0.0046 0.0189
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0104 0.0234
Brugia malayi Animal haem peroxidase family protein 0.0161 0.0344 0.14
Leishmania major hypothetical protein, conserved 0.0105 0.0216 0.1575
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0014 0.0389
Echinococcus granulosus segment polarity protein dishevelled 0.0018 0.0017 0.0071
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0095 0.0194 0.0789
Loa Loa (eye worm) RasGEF domain-containing protein 0.0012 0.0006 0.0023
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0223 0.0913
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0188 0.0406 0.1408
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0095 0.0194 0.5514
Schistosoma mansoni hypothetical protein 0.0048 0.0088 0.0465
Echinococcus multilocularis expressed protein 0.0033 0.0052 0.0141
Brugia malayi beta-lactamase 0.0107 0.0222 0.0903
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0088 0.0358
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.0125 0.0104
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0021 0.0086
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.0125 0.0104
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0044 0.0044
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0037 0.0196
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0044 0.0044
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0012 0.0006 0.0113
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0095 0.0194 0.0793
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0223 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0042 0.5297
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.013 0.0532
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.0222 0.0221
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0065 0.0125 0.0118
Loa Loa (eye worm) hypothetical protein 0.0164 0.0352 0.1439
Schistosoma mansoni hypothetical protein 0.0048 0.0088 0.0465
Brugia malayi Importin beta-1 subunit 0.0061 0.0117 0.0473
Brugia malayi regulator of G-protein signaling egl-10 0.0018 0.0017 0.0065
Leishmania major hypothetical protein, conserved 0.0012 0.0005 0.0037
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.008 0.2277
Brugia malayi nuclear hormone receptor 0.0024 0.0033 0.0127
Loa Loa (eye worm) hypothetical protein 0.0027 0.0039 0.0159
Brugia malayi AMP-binding enzyme family protein 0.022 0.0479 0.1954
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.007
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0117 0.0853
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0051 0.0094 0.0379
Plasmodium vivax patched family protein, putative 0.0012 0.0004 0.0127
Brugia malayi RasGEF domain containing protein 0.0012 0.0006 0.0018
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.006 0.0245
Entamoeba histolytica acyl-coA synthetase, putative 0.022 0.0479 0.9081
Onchocerca volvulus 0.0012 0.0004 0.0013
Brugia malayi Inositol-1 0.0038 0.0064 0.0255
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0088 0.0357
Leishmania major GTP-binding protein, putative 0.0045 0.008 0.0584
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0042 0.0042
Trypanosoma cruzi PAB1-binding protein , putative 0.0105 0.0216 0.1575
Brugia malayi nuclear receptor NHR-67 0.0024 0.0033 0.0127
Schistosoma mansoni peroxidasin 0.0161 0.0344 0.1827
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0384
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0008 0.0008
Onchocerca volvulus 0.0012 0.0004 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0155 0.0332 0.0337
Echinococcus granulosus importin 5 0.0012 0.0004 0.0016
Entamoeba histolytica hypothetical protein 0.005 0.0091 0.1719
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.0125 0.0104
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0159 0.0341 0.2484
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.0222 0.0221
Toxoplasma gondii small ubiquitin family modifier, putative 0.003 0.0046 0.0562
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Loa Loa (eye worm) hypothetical protein 0.0153 0.0325 0.1329
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0065 0.0125 0.0104
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0169 0.069
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0123 0.0651
Leishmania major hypothetical protein, conserved 0.0012 0.0004 0.0026
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0094 0.0252
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0011 0.0002 0.0006
Onchocerca volvulus 0.0999 0.2257 1
Brugia malayi Patched family protein 0.0012 0.0004 0.0012
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0164 0.0352 0.1439
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0051 0.0094 0.0411
Schistosoma mansoni hypothetical protein 0.0515 0.1153 0.6127
Loa Loa (eye worm) hypothetical protein 0.0027 0.0039 0.0159
Loa Loa (eye worm) hypothetical protein 0.0195 0.0423 0.1729
Plasmodium vivax hypothetical protein, conserved 0.0107 0.0222 0.6306
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0033 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0169 0.0169
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0011 0.0002 0.0006
Brugia malayi kap beta 3 protein 0.0012 0.0004 0.0009
Brugia malayi tailless protein 0.0024 0.0033 0.0127
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0014 0.0098
Brugia malayi Patched family protein 0.0012 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.1082 0.2445 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0094 0.0379
Giardia lamblia Sentrin 0.003 0.0046 0.5777
Brugia malayi Patched family protein 0.0012 0.0004 0.0012
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0051 0.0094 0.0385
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0019 0.0077
Schistosoma mansoni hypothetical protein 0.0012 0.0005 0.0026
Schistosoma mansoni carbonic anhydrase-related 0.0371 0.0824 0.4381
Loa Loa (eye worm) animal heme peroxidase 0.0161 0.0344 0.1404
Brugia malayi RNA, U transporter 1 0.0174 0.0375 0.1526
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0004 0.0047
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.007
Schistosoma mansoni carbonic anhydrase-related 0.0371 0.0824 0.4381
Schistosoma mansoni dep domain containing protein 0.0018 0.0017 0.0093
Echinococcus multilocularis carbonic anhydrase 0.0371 0.0824 0.2208
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.022 0.0479 0.0459
Mycobacterium ulcerans fatty-acid-CoA ligase 0.022 0.0479 0.0459
Loa Loa (eye worm) kap beta 3 protein 0.0012 0.0004 0.0014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.022 0.0479 0.0493
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0002 0.0012
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0051 0.0094 0.0385
Loa Loa (eye worm) hypothetical protein 0.0161 0.0344 0.1405
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0132
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0064 0.1212
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.0425 0.2258
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0033 0.0133
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0371 0.0824 0.3367
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0085 0.0171 0.0699
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Echinococcus multilocularis thioredoxin glutathione reductase 0.0083 0.0168 0.0449
Entamoeba histolytica hypothetical protein 0.0177 0.0382 0.7238
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0685 0.1541 0.1618
Brugia malayi Patched family protein 0.0012 0.0004 0.0012
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0002 0.0002
Plasmodium falciparum thioredoxin reductase 0.0029 0.0042 0.0515
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0012 0.0006 0.0032
Schistosoma mansoni hypothetical protein 0.0048 0.0088 0.0465
Loa Loa (eye worm) acetyltransferase 0.0147 0.0313 0.128
Brugia malayi photoreceptor-specific nuclear receptor 0.0051 0.0094 0.0379
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0012 0.0006 0.0113
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0042 0.0174
Plasmodium vivax ataxin-2 like protein, putative 0.0105 0.0216 0.6131
Entamoeba histolytica carbonic anhydrase, putative 0.0241 0.0528 1
Echinococcus multilocularis GPCR, family 2 0.0048 0.0088 0.0235
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0132
Toxoplasma gondii hypothetical protein 0.0371 0.0824 1
Brugia malayi hypothetical protein 0.0018 0.0017 0.0065
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0008 0.0008
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.0313 0.0839
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0196 0.0425 0.1138
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0021 0.0405
Echinococcus multilocularis protein patched 0.0084 0.0169 0.0452
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0051 0.0094 0.0384
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0019 0.005
Schistosoma mansoni RAR-like nuclear receptor 0.0051 0.0094 0.0501
Trichomonas vaginalis conserved hypothetical protein 0.4394 1 1
Loa Loa (eye worm) hypothetical protein 0.0161 0.0344 0.1404
Plasmodium vivax acetyl-CoA synthetase, putative 0.0065 0.0125 0.3541
Brugia malayi hypothetical protein 0.0177 0.0382 0.1556
Brugia malayi hypothetical protein 0.0027 0.0039 0.0154
Loa Loa (eye worm) hypothetical protein 0.0085 0.0171 0.0697
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0012 0.0006 0.0032
Brugia malayi Patched related family protein 4 0.0012 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0132
Schistosoma mansoni steroid hormone receptor ad4bp 0.0051 0.0094 0.0501
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0044 0.0832
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0611 0.137 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.0325 0.1329
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0012 0.0005 0.0151
Loa Loa (eye worm) hypothetical protein 0.0027 0.0039 0.0159
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0064 0.0261
Brugia malayi N-terminal motif family protein 0.0012 0.0006 0.0018
Brugia malayi Patched family protein 0.0012 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0161 0.0344 0.1404
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0065 0.0125 0.0104
Echinococcus multilocularis protein dispatched 1 0.0096 0.0196 0.0524
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0012 0.0005 0.0663
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0169 0.0452
Echinococcus granulosus geminin 0.0515 0.1153 0.4713
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.008 0.0973
Onchocerca volvulus Peroxidasin homolog 0.0161 0.0344 0.1518
Echinococcus granulosus ubiquitin 0.0011 0.0002 0.0006
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0223 0.0912
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0021 0.0081
Echinococcus granulosus mannose 6 phosphate isomerase 0.0095 0.0194 0.0794
Echinococcus granulosus segment polarity protein dishevelled 0.0018 0.0017 0.0071
Loa Loa (eye worm) hypothetical protein 0.0356 0.079 0.3228
Trypanosoma cruzi hypothetical protein 0.0012 0.0006 0.0042
Mycobacterium tuberculosis Probable dehydrogenase 0.0188 0.0406 0.0415
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0044 0.0535
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0042 0.0114
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0095 0.0194 0.052
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0222 0.0222
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0005 0.0005
Onchocerca volvulus 0.0012 0.0004 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0005 0.0037
Loa Loa (eye worm) hypothetical protein 0.0084 0.0169 0.0689
Plasmodium vivax small ubiquitin-related modifier, putative 0.003 0.0046 0.1315
Echinococcus granulosus importin subunit beta 1 0.0061 0.0117 0.0479
Brugia malayi hypothetical protein 0.0024 0.0033 0.0127
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0051 0.0615
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0065 0.0125 0.0118
Brugia malayi nuclear receptor NHR-88 0.0024 0.0033 0.0127
Brugia malayi Patched protein homolog 1 0.0012 0.0004 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0051 0.0094 0.0379
Schistosoma mansoni ran 0.0045 0.008 0.0426
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0223 0.0912
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0371 0.0824 0.3367
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0033 0.0087
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0209 0.0453 0.0466
Schistosoma mansoni hypothetical protein 0.0081 0.0162 0.086
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0042 0.0021
Echinococcus multilocularis Protein son of sevenless 0.0012 0.0006 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.022 0.0479 0.0459
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0155 0.0332 0.0337
Loa Loa (eye worm) hypothetical protein 0.0161 0.0344 0.1404
Loa Loa (eye worm) animal heme peroxidase 0.0161 0.0344 0.1404
Loa Loa (eye worm) animal heme peroxidase 0.0161 0.0344 0.1404
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0021 0.0154
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0012 0.0006 0.0113
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0042 0.1206
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.0222 0.0201
Leishmania major small ubiquitin protein, putative 0.003 0.0046 0.0336
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0169 0.0689
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0223 0.0912
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.0222 0.0221
Onchocerca volvulus Protein patched homolog 0.0012 0.0004 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0046 0.0046
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0064 0.0171
Echinococcus multilocularis carbonic anhydrase II 0.0611 0.137 0.3671
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0037 0.0099
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.008 0.0584
Echinococcus granulosus carbonic anhydrase 0.0371 0.0824 0.3371
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.008 0.008
Brugia malayi Niemann-Pick C1 protein precursor 0.0195 0.0423 0.1725
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0011 0.0002 0.0006
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0044 0.0044
Mycobacterium tuberculosis Conserved protein 0.0107 0.0222 0.0221
Brugia malayi AMP-binding enzyme family protein 0.0065 0.0125 0.0504
Echinococcus multilocularis hyperpolarization activated cyclic 0.0011 0.0002 0.0006
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0051 0.0094 0.0501
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0384
Brugia malayi AMP-binding enzyme family protein 0.022 0.0479 0.1954
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0021 0.0154
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0033 0.0127
Loa Loa (eye worm) patched family protein 0.0012 0.0004 0.0017
Onchocerca volvulus 0.0012 0.0004 0.0013
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0004 0.0047
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.002 0.0052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0008
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.022 0.0479 0.1695
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0012 0.0006 0.0113
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0094 0.0379
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0019
Loa Loa (eye worm) hypothetical protein 0.005 0.0091 0.0371
Loa Loa (eye worm) hypothetical protein 0.022 0.0479 0.1958
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0051 0.0368
Trichomonas vaginalis ras GTP exchange factor, putative 0.0012 0.0006 0.0006
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.0325 0.1325
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0123 0.0328
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0065 0.0125 0.0509
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0042 0.0308
Schistosoma mansoni rotamase 0.0033 0.0052 0.0279
Echinococcus multilocularis ecdysone induced protein 78C 0.0051 0.0094 0.0252
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0051 0.0094 0.0252
Echinococcus granulosus transportin 1 0.0012 0.0004 0.0016
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0014 0.0098
Schistosoma mansoni ap endonuclease 0.0019 0.0021 0.0114
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0611 0.137 0.7283
Treponema pallidum NADH oxidase 0.0029 0.0042 0.1045
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0611 0.137 0.7283
Loa Loa (eye worm) hypothetical protein 0.0161 0.0344 0.1404
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0094 0.0379
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.006 0.0161
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0044 0.0533
Onchocerca volvulus 0.0065 0.0125 0.0546
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0198 0.043 0.2286
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0019 0.0076
Brugia malayi Animal haem peroxidase family protein 0.0161 0.0344 0.14
Onchocerca volvulus 0.0161 0.0344 0.1517
Echinococcus multilocularis transportin 1 0.0012 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0161 0.0344 0.1404
Leishmania major carbonic anhydrase-like protein 0.0611 0.137 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0085 0.0171 0.0494
Echinococcus multilocularis muscleblind protein 1 0.1082 0.2445 0.6551
Brugia malayi RasGEF domain containing protein 0.0012 0.0006 0.0018
Brugia malayi Animal haem peroxidase family protein 0.0161 0.0344 0.14
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0042 0.2476
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.008 0.0328
Brugia malayi Patched family protein 0.0012 0.0004 0.0012
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0011 0.0002 0.0009
Schistosoma mansoni nuclear receptor 0.0024 0.0033 0.0173
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0042 0.0021
Trypanosoma cruzi ISWI complex protein 0.0015 0.0013 0.009
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0012 0.0006 0.0113
Toxoplasma gondii patched family protein 0.0012 0.0004 0.0054
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1646 0.3733 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0117 0.0477
Brugia malayi protein C24B5.3 0.0012 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0132
Plasmodium falciparum glutathione reductase 0.0082 0.0165 0.2003
Toxoplasma gondii propionate-CoA ligase 0.0065 0.0125 0.1513
Schistosoma mansoni ap endonuclease 0.0019 0.0021 0.0114
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0021 0.0021
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0014 0.0073
Echinococcus multilocularis neuropeptide s receptor 0.0463 0.1034 0.2769
Plasmodium falciparum importin beta, putative 0.0061 0.0117 0.142
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0044 0.1115
Loa Loa (eye worm) hypothetical protein 0.0161 0.0344 0.1404
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0044 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0021 0.1238
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.0222 0.0201
Entamoeba histolytica Ran family GTPase 0.0045 0.008 0.152
Schistosoma mansoni hypothetical protein 0.0048 0.0088 0.0465
Schistosoma mansoni hypothetical protein 0.0021 0.0025 0.0132
Loa Loa (eye worm) RasGEF domain-containing protein 0.0012 0.0006 0.0023
Schistosoma mansoni patched 1 0.0084 0.0169 0.0897
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0159 0.0341 0.032
Trypanosoma cruzi trypanothione reductase, putative 0.0082 0.0165 0.1204
Brugia malayi steroid hormone receptor 0.0051 0.0094 0.0379
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0021 0.0057
Echinococcus granulosus carbonic anhydrase II 0.0611 0.137 0.5603
Trypanosoma brucei phosphomannose isomerase 0.0095 0.0194 0.1416
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0002 0.0012
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0012 0.0004 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0222 0.162
Loa Loa (eye worm) hypothetical protein 0.0371 0.0824 0.337
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0026 0.0105
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0091 0.0091
Echinococcus multilocularis carbonic anhydrase 0.0371 0.0824 0.2208
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0094 0.0252
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0042 0.003
Leishmania major trypanothione reductase 0.0082 0.0165 0.1204
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0012 0.0006 0.0024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.0325 0.1325
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0013 0.0007 0.0048
Onchocerca volvulus Protein ultraspiracle homolog 0.0051 0.0094 0.0411
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0171 0.2072
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.008 0.0584
Mycobacterium tuberculosis Conserved protein 0.0107 0.0222 0.0221
Trichomonas vaginalis hypothetical protein 0.0012 0.0004 0.0004
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0067 0.0807
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0033 0.0173
Loa Loa (eye worm) hypothetical protein 0.022 0.0479 0.1958
Echinococcus granulosus Niemann Pick C1 protein 0.0195 0.0423 0.1731
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0222 0.162
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0065 0.0125 0.051
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0039 0.0154
Loa Loa (eye worm) hypothetical protein 0.0161 0.0344 0.1404
Schistosoma mansoni hypothetical protein 0.0015 0.0013 0.0067
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.003 0.0046 0.0246
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0065 0.0125 0.0909
Plasmodium falciparum ataxin-2 like protein, putative 0.0105 0.0216 0.2621
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0052 0.0052
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0065 0.0125 0.0118
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0117 0.0853
Schistosoma mansoni zinc finger protein 0.0027 0.0038 0.0203
Echinococcus multilocularis geminin 0.0515 0.1153 0.3088
Toxoplasma gondii hypothetical protein 0.0018 0.0017 0.0211
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0012 0.0006 0.0113
Onchocerca volvulus 0.0161 0.0344 0.1517
Loa Loa (eye worm) hypothetical protein 0.0107 0.0222 0.0907
Loa Loa (eye worm) hypothetical protein 0.0027 0.0039 0.0159
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0065 0.0125 0.0118
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0088 0.0352
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0017 0.0068
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.0125 0.0104
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.008 0.0327
Brugia malayi protein C24B5.3 0.0012 0.0004 0.0012
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0042 0.0226
Schistosoma mansoni nuclear hormone receptor 0.0051 0.0094 0.0501
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0123 0.05
Brugia malayi Peroxidasin 0.0161 0.0344 0.1401
Entamoeba histolytica phosphomannose isomerase, putative 0.0095 0.0194 0.3682
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0223 0.4234
Brugia malayi Cyclic-nucleotide gated cation channel 0.0011 0.0002 0.0003
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0011 0.0029
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0012 0.0005 0.0101
Loa Loa (eye worm) hypothetical protein 0.0161 0.0344 0.1404
Echinococcus granulosus Protein son of sevenless 0.0012 0.0006 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0008 0.0008
Brugia malayi nuclear receptor NHR-88 0.0051 0.0094 0.0379
Loa Loa (eye worm) hypothetical protein 0.0103 0.0212 0.0865
Brugia malayi Animal haem peroxidase family protein 0.0161 0.0344 0.14
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0196 0.0425 0.1737
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0017 0.0071
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0171 0.4142
Mycobacterium ulcerans acyl-CoA synthetase 0.022 0.0479 0.0459
Schistosoma mansoni cpg binding protein 0.0059 0.0111 0.0591
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0065 0.0125 0.0118
Mycobacterium ulcerans acyl-CoA synthetase 0.022 0.0479 0.0459
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0065 0.0125 0.0504
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0008 0.0008
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0033 0.0133
Schistosoma mansoni hypothetical protein 0.0515 0.1153 0.6127
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.0222 0.0221
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0088 0.0235
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0065 0.0125 0.0104
Schistosoma mansoni dishevelled 0.0018 0.0017 0.0093
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0017 0.0093
Entamoeba histolytica hypothetical protein 0.0012 0.0006 0.0113
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0222 0.0222
Echinococcus multilocularis Niemann Pick C1 protein 0.0279 0.0615 0.1646
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0095 0.0194 0.0194
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0055 0.0044
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0018 0.0017 0.0047
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0222 0.1181
Echinococcus granulosus dnaJ subfamily B 0.0835 0.1881 0.7693
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Brugia malayi Bromodomain containing protein 0.0042 0.0073 0.0294
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0042 0.0515
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0042 0.0515
Mycobacterium ulcerans beta-lactamase 0.0107 0.0222 0.0201
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0088 0.0352
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0088 0.0358
Echinococcus granulosus carbonic anhydrase 0.0371 0.0824 0.3371
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0051 0.0094 0.0501
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0067 0.1261
Trypanosoma cruzi ISWI complex protein 0.0015 0.0013 0.009
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.0084 0.0226
Trypanosoma cruzi small ubiquitin protein, putative 0.003 0.0046 0.0336
Trypanosoma cruzi hypothetical protein 0.0012 0.0006 0.0042
Leishmania major carbonic anhydrase family protein, putative 0.0241 0.0528 0.385
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0012 0.0005 0.0022
Echinococcus multilocularis hyperpolarization activated cyclic 0.0011 0.0002 0.0006
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0111 0.0453
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0223 0.0699
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0051 0.0094 0.0385
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0261 0.1387
Brugia malayi Patched family protein 0.0012 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0384
Mycobacterium ulcerans acetyl-CoA synthetase 0.0065 0.0125 0.0104
Brugia malayi CXXC zinc finger family protein 0.0059 0.0111 0.0448
Schistosoma mansoni z-protein (S1r protein) 0.0018 0.0017 0.0093
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0222 0.1181
Schistosoma mansoni hypothetical protein 0.0104 0.0215 0.1144
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.0222 0.0221
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.1396 0.3161 0.3335
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Entamoeba histolytica hypothetical protein 0.0177 0.0382 0.7238
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.0094 0.0501
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0223 0.1629
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0051 0.0094 0.0384
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0044 0.1124
Mycobacterium ulcerans hypothetical protein 0.022 0.0479 0.0459
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0042 0.0308
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0094 0.0379
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0012 0.0005 0.0151
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0014 0.0037
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0033 0.0173
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0065 0.0125 0.0509
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0021 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0051 0.0094 0.0379
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0012 0.0006 0.0113
Brugia malayi isocitrate dehydrogenase 0.0016 0.0014 0.005
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0033 0.0087
Brugia malayi CHE-14 protein 0.0084 0.0169 0.0684
Brugia malayi N-terminal motif family protein 0.0012 0.0006 0.0018
Trypanosoma cruzi phosphomannose isomerase, putative 0.0095 0.0194 0.1416
Toxoplasma gondii hypothetical protein 0.0012 0.0004 0.0054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.002 0.0104
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0132
Brugia malayi AMP-binding enzyme family protein 0.022 0.0479 0.1954
Onchocerca volvulus Peroxidase homolog 0.0161 0.0344 0.1517
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0017 0.0047
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.002 0.008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0042 0.0308
Brugia malayi AMP-binding enzyme family protein 0.0065 0.0125 0.0504
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0051 0.0368
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0065 0.0125 0.0909
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0014 0.0055
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0042 0.2476
Loa Loa (eye worm) hypothetical protein 0.0371 0.0824 0.337
Mycobacterium tuberculosis Conserved protein 0.0107 0.0222 0.0221
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0021 0.0607
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0033 0.0133
Loa Loa (eye worm) hypothetical protein 0.0106 0.022 0.0899
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0014 0.0056
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0002 0.0012
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0011 0.0002 0.0003
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0042 0.0308
Schistosoma mansoni bromodomain containing protein 0.0071 0.0138 0.0736
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0033 0.0132
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0033 0.0133
Onchocerca volvulus Peroxidase homolog 0.0161 0.0344 0.1517
Entamoeba histolytica HEAT repeat domain containing protein 0.0012 0.0004 0.0073
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0012 0.0006 0.0113
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0132
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0132
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0012 0.0006 0.0042
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.002 0.0104
Brugia malayi RNA binding protein 0.0064 0.0123 0.0495
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0012 0.0006 0.0016
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0044 0.0044
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0065 0.0125 0.0118
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0014 0.005
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0002 0.0009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0042 0.0308
Brugia malayi PHD-finger family protein 0.0032 0.005 0.02
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0042 0.0308
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0065 0.0125 0.0118
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0017 0.0088
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0107 0.0222 0.0907
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.0222 0.0907
Loa Loa (eye worm) hypothetical protein 0.0048 0.0088 0.0357
Loa Loa (eye worm) steroid hormone receptor 0.0051 0.0094 0.0384
Plasmodium vivax transportin, putative 0.0012 0.0004 0.011
Loa Loa (eye worm) hypothetical protein 0.0161 0.0344 0.1404
Brugia malayi hypothetical protein 0.0012 0.0004 0.0012
Leishmania major hypothetical protein, conserved 0.0107 0.0222 0.162
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0155 0.0332 0.0337
Echinococcus multilocularis zinc finger protein 0.0027 0.0038 0.0102
Schistosoma mansoni hypothetical protein 0.0081 0.0162 0.086
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0011 0.0057
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0014 0.0166
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0104 0.0096
Brugia malayi hypothetical protein 0.0105 0.0216 0.0878
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0065 0.0125 0.0334
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0065 0.0125 0.1513
Loa Loa (eye worm) hypothetical protein 0.022 0.0479 0.1958
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0223 0.4234
Brugia malayi RasGEF domain containing protein 0.0012 0.0006 0.0018
Mycobacterium ulcerans carbonic anhydrase 0.0241 0.0528 0.0507
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.0084 0.0345
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0025 0.0097
Schistosoma mansoni hypothetical protein 0.0177 0.0382 0.203
Toxoplasma gondii ABC1 family protein 0.0107 0.0222 0.2695
Schistosoma mansoni hypothetical protein 0.0081 0.0162 0.086
Leishmania major hypothetical protein, conserved 0.0015 0.0013 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0051 0.0094 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0002 0.0002
Toxoplasma gondii exonuclease III APE 0.0019 0.0021 0.0259
Loa Loa (eye worm) hypothetical protein 0.0371 0.0824 0.337
Loa Loa (eye worm) hypothetical protein 0.0161 0.0344 0.1404
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.0222 0.162
Onchocerca volvulus 0.0012 0.0004 0.0013
Echinococcus multilocularis son of sevenless 1 0.0012 0.0006 0.0016
Loa Loa (eye worm) RNA binding protein 0.0064 0.0123 0.05
Brugia malayi hypothetical protein 0.0068 0.0131 0.0532
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0011 0.0002 0.0008
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0371 0.0824 0.3367
Loa Loa (eye worm) hypothetical protein 0.0065 0.0125 0.0509
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0012 0.0006 0.0006
Brugia malayi beta-lactamase family protein 0.0107 0.0222 0.0903
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0169 0.069
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0033 0.0173
Plasmodium falciparum acyl-CoA synthetase 0.0164 0.0352 0.4274
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0025 0.01
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0094 0.0385
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.0425 0.2258
Onchocerca volvulus 0.0051 0.0094 0.0411
Onchocerca volvulus 0.0059 0.0111 0.0486
Schistosoma mansoni importin-beta 2 0.0012 0.0004 0.0021
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0065 0.0125 0.0504
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.0117 0.142
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0051 0.0961
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0008 0.0008
Leishmania major 4-coumarate:coa ligase-like protein 0.022 0.0479 0.3496
Schistosoma mansoni importin beta-1 0.0061 0.0117 0.0622
Echinococcus multilocularis ras GTP exchange factor 0.0012 0.0006 0.0016
Onchocerca volvulus 0.0106 0.022 0.097
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0042 0.0308
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0044 0.0533
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0042 0.0308
Brugia malayi N-terminal motif family protein 0.0356 0.079 0.3225
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0223 0.0223
Schistosoma mansoni hypothetical protein 0.0081 0.0162 0.086
Trypanosoma brucei PAB1-binding protein , putative 0.0105 0.0216 0.1575
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0159 0.0341 0.4132
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0011
Echinococcus granulosus zinc finger protein 0.0027 0.0038 0.0156
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0085 0.0171 1
Brugia malayi hypothetical protein 0.0012 0.0004 0.0012
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0094 0.0379
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0017 0.0071
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.008 0.0971
Mycobacterium ulcerans hypothetical protein 0.0107 0.0222 0.0201
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0014 0.0037
Echinococcus granulosus expressed protein 0.0033 0.0052 0.0214
Plasmodium falciparum small ubiquitin-related modifier 0.003 0.0046 0.0562
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0065 0.0125 0.1513
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0159 0.0341 0.2484
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0002 0.0012
Mycobacterium ulcerans integral membrane transporter 0.0159 0.0341 0.032
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0008
Echinococcus multilocularis segment polarity protein dishevelled 0.0018 0.0017 0.0047
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0223 0.1629
Trichomonas vaginalis helicase, putative 0.0013 0.0008 0.0008
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.0222 0.0221
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0171 0.7398
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0008 0.0008
Echinococcus multilocularis tumor protein p63 0.0727 0.1636 0.4384
Schistosoma mansoni nuclear receptor 0.0024 0.0033 0.0173
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.008 0.0327
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0051 0.0094 0.0379
Onchocerca volvulus 0.0012 0.0004 0.0013
Brugia malayi Patched family protein 0.0012 0.0004 0.0012
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0223 0.0202
Echinococcus granulosus snurportin 1 0.0654 0.1468 0.6003
Schistosoma mansoni peptidase Clp (S14 family) 0.0085 0.0171 0.0908
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0051 0.0094 0.0379
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.0244 0.2963
Plasmodium falciparum carbonic anhydrase 0.0371 0.0824 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Brugia malayi nuclear receptor RXR 0.0027 0.0039 0.0154
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0017
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0011 0.0029
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0011 0.0044
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0023
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0051 0.0094 0.0384
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0033 0.0127
Trichomonas vaginalis dullard protein, putative 0.0012 0.0005 0.0005
Trypanosoma brucei carbonic anhydrase-like protein 0.0611 0.137 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0209 0.0453 0.0466
Onchocerca volvulus Putative sulfate transporter 0.0999 0.2257 1
Mycobacterium ulcerans lipase LipD 0.0107 0.0222 0.0201
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0014 0.0166
Brugia malayi AMP-binding enzyme family protein 0.0065 0.0125 0.0504
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0654 0.1468 0.6002
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0064 0.0465
Brugia malayi Muscleblind-like protein 0.1082 0.2445 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0008 0.0008
Loa Loa (eye worm) DR-78 0.0024 0.0033 0.0132
Brugia malayi TAR-binding protein 0.0064 0.0123 0.0495
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0051 0.0094 0.0501
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0094 0.0385
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0065 0.0125 0.0104
Echinococcus granulosus ecdysone induced protein 78C 0.0051 0.0094 0.0385
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0088 0.0235
Trypanosoma cruzi importin beta-1 subunit, putative 0.005 0.0091 0.066
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0042 0.0308
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0008 0.0008
Trichomonas vaginalis esterase, putative 0.0107 0.0222 0.0222
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0055 0.0042
Onchocerca volvulus 0.0065 0.0125 0.0546
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0033 0.0127
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0012 0.0005 0.0065
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0065 0.0125 0.0104
Onchocerca volvulus Bile acid receptor homolog 0.0051 0.0094 0.0411
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0188 0.0406 0.0415
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0223 0.0223
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0044 0.5472
Leishmania major pantothenate kinase subunit, putative 0.0013 0.0007 0.0048
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0065 0.0125 0.0104
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0012 0.0005 0.0037
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0051 0.0368
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0005 0.0028
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0018 0.0017 0.0093
Brugia malayi phosphofructokinase 0.0108 0.0223 0.0908
Echinococcus multilocularis snurportin 1 0.0654 0.1468 0.3933
Plasmodium falciparum thioredoxin reductase 0.0082 0.0165 0.2003
Brugia malayi conserved hypotetical protein 0.0024 0.0033 0.0127
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0196 0.0425 0.1138

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % Ability to supress maximal electroshock induced tonic extensor convulsion in mice after oral administration at 50 mg/kg ChEMBL. 6716402

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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