Detailed information for compound 323734

Basic information

Technical information
  • TDR Targets ID: 323734
  • Name: 3-(2,4-difluorophenyl)sulfanyl-6-methylsulfon yl-1H-indole-2-carbonitrile
  • MW: 364.39 | Formula: C16H10F2N2O2S2
  • H donors: 1 H acceptors: 3 LogP: 3.61 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1[nH]c2c(c1Sc1ccc(cc1F)F)ccc(c2)S(=O)(=O)C
  • InChi: 1S/C16H10F2N2O2S2/c1-24(21,22)10-3-4-11-13(7-10)20-14(8-19)16(11)23-15-5-2-9(17)6-12(15)18/h2-7,20H,1H3
  • InChiKey: XAOIOAYWZAVEIW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(2,4-difluorophenyl)thio]-6-methylsulfonyl-1H-indole-2-carbonitrile
  • 3-[(2,4-difluorophenyl)thio]-6-mesyl-1H-indole-2-carbonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni protein kinase 0.016 0.0558 0.0547
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0096 0.0207 0.0163
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.1091 0.1081
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0113 0.03 0.2514
Plasmodium vivax protein kinase Crk2 0.0137 0.0433 0.6012
Brugia malayi Protein kinase domain containing protein 0.01 0.0228 0.0236
Echinococcus granulosus epidermal growth factor receptor 0.0419 0.1995 0.1958
Plasmodium vivax protein kinase, putative 0.0063 0.0024 0.0183
Brugia malayi Blistered cuticle protein 3 0.0071 0.0068 0.0071
Entamoeba histolytica PH domain containing protein kinase, putative 0.0135 0.0422 0.0664
Loa Loa (eye worm) AGC/NDR protein kinase 0.0168 0.0606 0.0628
Trypanosoma cruzi casein kinase, putative 0.0121 0.0345 0.0347
Loa Loa (eye worm) thyroid receptor interactor 0.0115 0.0311 0.0322
Echinococcus multilocularis N chimaerin 0.0096 0.0207 0.019
Loa Loa (eye worm) hypothetical protein 0.0106 0.0262 0.0271
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0101 0.0234 0.0218
Echinococcus granulosus casein kinase i 0.0121 0.0345 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0078 0.0108
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0161 0.0566 0.055
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0197 0.0765 0.0723
Brugia malayi protein-tyrosine kinase 0.0161 0.0566 0.0587
Loa Loa (eye worm) hypothetical protein 0.0116 0.0319 0.0331
Trypanosoma cruzi aurora B kinase, putative 0.016 0.0558 0.0567
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.0606 0.0596
Leishmania major casein kinase II, putative 0.0112 0.0296 0.0296
Brugia malayi map kinase activated protein kinase protein 2 0.0419 0.1992 0.2065
Echinococcus multilocularis mitogen activated protein kinase 11 0.1802 0.9646 0.9645
Brugia malayi Animal haem peroxidase family protein 0.0071 0.0068 0.0071
Schistosoma mansoni serine/threonine protein kinase 0.0283 0.1242 0.1233
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0079 0.0111 0.0104
Loa Loa (eye worm) hypothetical protein 0.0077 0.01 0.0104
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0168 0.0606 0.0591
Trichomonas vaginalis AGC family protein kinase 0.0093 0.0188 0.0287
Brugia malayi Animal haem peroxidase family protein 0.0071 0.0068 0.0071
Echinococcus multilocularis expressed protein 0.0095 0.0198 0.0182
Trichomonas vaginalis CMGC family protein kinase 0.0095 0.0201 0.0308
Loa Loa (eye worm) hypothetical protein 0.0088 0.0164 0.017
Schistosoma mansoni hypothetical protein 0.0106 0.0262 0.0251
Schistosoma mansoni tyrosine kinase 0.0372 0.1732 0.1723
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0113 0.03 0.0284
Echinococcus granulosus activin receptor type 0.009 0.0171 0.0127
Loa Loa (eye worm) hypothetical protein 0.0145 0.0475 0.0492
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0234 0.036
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0095 0.0198 0.0194
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0276 0.12 0.1244
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0461 0.0726
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0082 0.0127 0.0083
Brugia malayi Immunoglobulin I-set domain containing protein 0.0274 0.1188 0.1232
Loa Loa (eye worm) hypothetical protein 0.0313 0.1406 0.1458
Brugia malayi Protein kinase domain containing protein 0.0633 0.3178 0.3295
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0188 0.0712 0.0728
Trichomonas vaginalis CMGC family protein kinase 0.0168 0.0605 0.0959
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.039 0.1833 0.1901
Entamoeba histolytica protein kinase , putative 0.016 0.0558 0.0883
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.016 0.0558 0.0883
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0465 0.2245 0.2327
Schistosoma mansoni serine/threonine protein kinase 0.0274 0.1189 0.1179
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0391 0.184 0.2956
Trypanosoma brucei aurora B kinase 0.016 0.0558 0.0567
Entamoeba histolytica protein kinase, putative 0.0095 0.0198 0.0302
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0188 0.0712 0.1133
Echinococcus granulosus protein kinase shaggy 0.0142 0.0461 0.0418
Echinococcus multilocularis mitogen activated protein kinase 3 0.0095 0.0201 0.0185
Entamoeba histolytica protein kinase domain containing protein 0.0142 0.0461 0.0726
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0233 0.0964 0.0923
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.052 0.0822
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0126 0.037 0.0373
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0234 0.0223
Brugia malayi serine/threonine protein kinase 6 0.016 0.0558 0.0578
Brugia malayi Peroxidasin 0.0106 0.0262 0.0271
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0228 0.0236
Leishmania major protein kinase, putative 0.0113 0.03 0.03
Brugia malayi Immunoglobulin I-set domain containing protein 0.0465 0.2245 0.2327
Echinococcus multilocularis hypothetical protein 0.0106 0.0262 0.0246
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0867 0.4469 0.7205
Brugia malayi SH2 domain containing protein 0.0416 0.1977 0.205
Loa Loa (eye worm) hypothetical protein 0.0077 0.0099 0.0102
Loa Loa (eye worm) hypothetical protein 0.0149 0.0498 0.0516
Echinococcus multilocularis serine:threonine protein kinase 0.0127 0.0377 0.0361
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0027 0.0025
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0095 0.0201 0.1656
Echinococcus granulosus serine/threonine protein kinase 0.0152 0.0515 0.0472
Schistosoma mansoni serine/threonine protein kinase 0.0233 0.0964 0.0954
Echinococcus multilocularis protein tyrosine kinase 0.0575 0.2855 0.2843
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0234 0.036
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0126 0.037 0.0384
Echinococcus multilocularis roundabout 2 0.0128 0.038 0.0364
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0113 0.03 0.4123
Trichomonas vaginalis AGC family protein kinase 0.0093 0.0188 0.0287
Trypanosoma cruzi polo-like protein kinase, putative 0.029 0.1277 0.1314
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0095 0.0201 0.0198
Entamoeba histolytica serine/threonine protein kinase, putative 0.0101 0.0234 0.036
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0234 0.036
Loa Loa (eye worm) TK protein kinase 0.0109 0.0275 0.0285
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0027 0.0025
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.024 0.1 0.1037
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.009 0.0171 0.0166
Brugia malayi serine/threonine kinase 12 0.016 0.0558 0.0578
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0098 0.0215 0.0198
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0975 0.5071 0.8177
Loa Loa (eye worm) hypothetical protein 0.0116 0.0319 0.0331
Echinococcus multilocularis rac serine:threonine kinase 0.0152 0.0515 0.0499
Entamoeba histolytica protein kinase domain containing protein 0.009 0.0171 0.0259
Giardia lamblia Kinase, NEK 0.015 0.0504 0.1479
Loa Loa (eye worm) hypothetical protein 0.0217 0.0875 0.0907
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0663 0.3341 1
Giardia lamblia Kinase, CMGC CDK 0.0137 0.0433 0.1266
Echinococcus multilocularis protein kinase shaggy 0.0142 0.0461 0.0445
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.029 0.1277 0.1314
Schistosoma mansoni cell adhesion molecule 0.0108 0.0272 0.0262
Brugia malayi Protein kinase domain containing protein 0.023 0.0948 0.0983
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0153 0.052 0.0528
Echinococcus granulosus tyrosine protein kinase HCK 0.0109 0.0275 0.0231
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0147 0.049 0.0774
Echinococcus multilocularis dual specificity 0.0153 0.052 0.0504
Trichomonas vaginalis AGC family protein kinase 0.019 0.0724 0.1152
Loa Loa (eye worm) hypothetical protein 0.0071 0.0068 0.0071
Onchocerca volvulus 0.0071 0.0068 0.0137
Brugia malayi Protein kinase domain containing protein 0.019 0.0724 0.0751
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0234 0.036
Schistosoma mansoni serine/threonine protein kinase 0.023 0.0948 0.0938
Echinococcus multilocularis tyrosine protein kinase shark 0.0323 0.1459 0.1445
Echinococcus multilocularis NCK adaptor protein 0.0091 0.0176 0.0159
Echinococcus granulosus dual specificity 0.0153 0.052 0.0477
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.106 0.5538 0.5518
Entamoeba histolytica protein kinase, putative 0.0095 0.02 0.0305
Loa Loa (eye worm) hypothetical protein 0.0369 0.1715 0.1778
Echinococcus granulosus fibroblast growth factor receptor 4 0.0254 0.108 0.104
Loa Loa (eye worm) phosphatidylinositol 3 0.1662 0.8872 0.9198
Loa Loa (eye worm) hypothetical protein 0.0111 0.029 0.0301
Echinococcus granulosus Protein kinase C brain isozyme 0.0256 0.1089 0.1048
Trichomonas vaginalis CAMK family protein kinase 0.029 0.1277 0.2046
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0414 0.1965 0.1951
Loa Loa (eye worm) hypothetical protein 0.0481 0.2335 0.2421
Brugia malayi Protein kinase domain containing protein 0.0581 0.289 0.2996
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0419 0.1995 0.1958
Echinococcus multilocularis Immunoglobulin 0.0077 0.0099 0.0082
Plasmodium vivax serine/threonine protein kinase 6, putative 0.016 0.0558 0.7795
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0159 0.0553 0.0537
Echinococcus granulosus mitogen activated protein kinase 11 0.1802 0.9646 0.9644
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0142 0.0461 0.391
Loa Loa (eye worm) hypothetical protein 0.0093 0.0189 0.0196
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0202 0.079 0.0819
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0753 0.3842 0.3832
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0098 0.0215 0.0171
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0256 0.1091 0.1131
Loa Loa (eye worm) hypothetical protein 0.0475 0.2303 0.2388
Plasmodium falciparum glycogen synthase kinase 3 0.0142 0.0461 0.6412
Trypanosoma brucei polo-like protein kinase 0.029 0.1277 0.1314
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0096 0.0207 0.0316
Loa Loa (eye worm) hypothetical protein 0.01 0.0228 0.0236
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0128 0.0382 0.0366
Trypanosoma cruzi casein kinase II, putative 0.0112 0.0296 0.0296
Schistosoma mansoni tyrosine kinase 0.0323 0.1459 0.145
Entamoeba histolytica protein kinase 2, putative 0.0143 0.0463 0.0731
Trichomonas vaginalis CK1 family protein kinase 0.0121 0.0345 0.054
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.024 0.1 0.0985
Echinococcus granulosus tyrosine protein kinase Src64B 0.0197 0.0765 0.0723
Toxoplasma gondii AGC kinase 0.0126 0.037 0.3125
Leishmania major phosphatidylinositol 3-kinase, putative 0.0188 0.0712 0.0728
Echinococcus multilocularis insulin receptor 0.0467 0.2258 0.2245
Loa Loa (eye worm) hypothetical protein 0.0067 0.0044 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0419 0.1992 0.1983
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0077 0.0099 0.0088
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0126 0.037 0.0327
Trypanosoma brucei Casein kinase II 0.0112 0.0296 0.0296
Loa Loa (eye worm) animal heme peroxidase 0.0071 0.0068 0.0071
Entamoeba histolytica protein kinase domain containing protein 0.0142 0.0461 0.0726
Brugia malayi Protein kinase domain containing protein 0.039 0.1833 0.1901
Trypanosoma brucei protein kinase, putative 0.009 0.0171 0.0166
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0088 0.0164 0.017
Giardia lamblia Kinase, CMGC DYRK 0.0153 0.052 0.1528
Entamoeba histolytica protein kinase domain containing protein 0.0153 0.052 0.0822
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0095 0.0198 0.0194
Plasmodium vivax tyrosine kinase-like protein, putative 0.0092 0.0186 0.2492
Echinococcus multilocularis Zinc finger, PHD finger 0.0188 0.0712 0.0697
Echinococcus multilocularis cyclin dependent kinase 1 0.0137 0.0433 0.0417
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0433 0.0681
Trichomonas vaginalis CAMK family protein kinase 0.029 0.1277 0.2046
Echinococcus granulosus raf serine:threonine protein kinase 0.0091 0.0178 0.0134
Echinococcus granulosus hypothetical protein 0.0126 0.037 0.0327
Entamoeba histolytica cell division protein kinase 2, putative 0.0137 0.0433 0.0681
Giardia lamblia Kinase, CAMK CAMKL 0.011 0.0285 0.0823
Schistosoma mansoni tyrosine kinase 0.0419 0.1995 0.1986
Trichomonas vaginalis AGC family protein kinase 0.0278 0.1212 0.1941
Trichomonas vaginalis AGC family protein kinase 0.016 0.0558 0.0883
Plasmodium vivax serine/threonine protein kinase, putative 0.0095 0.0198 0.2664
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.1089 0.1079
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0197 0.0765 0.0749
Echinococcus multilocularis 0.0126 0.037 0.0354
Plasmodium falciparum protein kinase 5 0.0137 0.0433 0.6012
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0483 0.2348 0.2313
Giardia lamblia Kinase, CMGC CDK 0.0137 0.0433 0.1266
Loa Loa (eye worm) hypothetical protein 0.0077 0.0099 0.0102
Schistosoma mansoni protein kinase 0.0209 0.083 0.082
Brugia malayi Sex muscle abnormal protein 5 0.0088 0.0164 0.017
Echinococcus granulosus tyrosine protein kinase shark 0.0323 0.1459 0.1421
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0188 0.0178
Brugia malayi ribosomal protein S6 kinase alpha 3 0.013 0.0394 0.0408
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0078 0.0108
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0126 0.037 0.0373
Brugia malayi probable protein kinase 0.0284 0.1246 0.1292
Echinococcus granulosus mitogen activated protein kinase 3 0.0095 0.0201 0.0157
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0296 0.046
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1179 0.6199 1
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0142 0.0461 0.045
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0234 0.097 0.1005
Schistosoma mansoni serine/threonine kinase 0.0243 0.1021 0.1011
Loa Loa (eye worm) hypothetical protein 0.0202 0.0791 0.082
Trypanosoma brucei rac serine-threonine kinase, putative 0.0278 0.1212 0.1247
Echinococcus granulosus ephrin type A receptor 4 A 0.0114 0.0306 0.0262
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0034 0.0023
Loa Loa (eye worm) TK protein kinase 0.0274 0.1188 0.1232
Echinococcus granulosus tyrosine protein kinase Blk 0.0161 0.0566 0.0524
Leishmania major protein kinase, putative 0.0096 0.0207 0.0203
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0088 0.0164 0.0153
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0095 0.02 0.0305
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0083 0.0136 0.0092
Onchocerca volvulus 0.0071 0.0068 0.0137
Giardia lamblia Kinase, CMGC SRPK 0.0095 0.0198 0.0561
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0188 0.0712 0.1133
Schistosoma mansoni growth factor receptor-bound protein 0.0091 0.0176 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.0495 0.0484
Trichomonas vaginalis cAMP-dependent protein kinase catalytic subunit, putative 0.0064 0.0027 0.0025
Schistosoma mansoni tyrosine kinase 0.027 0.1168 0.1158
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0077 0.0099 0.0088
Brugia malayi Fibronectin type III domain containing protein 0.0093 0.0189 0.0196
Loa Loa (eye worm) TK/FER protein kinase 0.0416 0.1977 0.205
Echinococcus granulosus cyclin dependent kinase 7 0.0132 0.0404 0.0361
Echinococcus granulosus tyrosine protein kinase Srms 0.0525 0.2579 0.2545
Giardia lamblia Kinase, CMGC MAPK 0.0095 0.0201 0.0572
Plasmodium falciparum calcium-dependent protein kinase 5 0.0113 0.03 0.4123
Echinococcus granulosus growth factor receptor bound protein 2 0.0091 0.0176 0.0131
Entamoeba histolytica protein kinase, putative 0.0084 0.0141 0.021
Schistosoma mansoni titin 0.0078 0.0107 0.0096
Loa Loa (eye worm) hypothetical protein 0.0071 0.0068 0.0071
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0256 0.1091 0.1051
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0214 0.086 0.0892
Brugia malayi hypothetical protein 0.0093 0.0189 0.0196
Schistosoma mansoni serine/threonine protein kinase 0.0253 0.1074 0.1064
Entamoeba histolytica protein kinase domain containing protein 0.0112 0.0296 0.046
Loa Loa (eye worm) hypothetical protein 0.0071 0.0068 0.0071
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0168 0.0605 0.0616
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0234 0.0223
Loa Loa (eye worm) hypothetical protein 0.0242 0.1012 0.1049
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0391 0.184 0.2956
Schistosoma mansoni serine/threonine protein kinase 0.0233 0.0964 0.0954
Loa Loa (eye worm) animal heme peroxidase 0.0091 0.0176 0.0183
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0461 0.0726
Schistosoma mansoni kinase 0.0095 0.0199 0.0188
Echinococcus granulosus titin 0.0078 0.0107 0.0062
Trypanosoma cruzi casein kinase, putative 0.0121 0.0345 0.0347
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0867 0.4469 0.7205
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0095 0.0199 0.0207
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0283 0.1242 0.1228
Echinococcus granulosus tyrosine kinase 0.01 0.0228 0.0184
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0197 0.0765 0.0749
Schistosoma mansoni serine/threonine-protein kinase 0.0152 0.0515 0.0504
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.009 0.0171 0.0166
Schistosoma mansoni vesicular amine transporter 0.0077 0.0099 0.0088
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0027 0.0025
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0269 0.1161 0.1203
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0197 0.0765 0.0749
Schistosoma mansoni serine/threonine protein kinase 0.0505 0.2469 0.2461
Schistosoma mansoni tyrosine kinase 0.0419 0.1995 0.1986
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0382 0.06
Echinococcus granulosus NCK adaptor protein 0.0088 0.0164 0.012
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0095 0.0201 0.0198
Entamoeba histolytica protein kinase, putative 0.016 0.0558 0.0883
Entamoeba histolytica protein kinase, putative 0.0098 0.0215 0.0329
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0168 0.0605 0.0627
Echinococcus multilocularis calcium activated potassium channel 0.0149 0.0496 0.048
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0073 0.0078 0.0108
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.016 0.0558 0.0883
Echinococcus multilocularis serine:threonine protein kinase N2 0.0303 0.1354 0.1339
Onchocerca volvulus 0.0145 0.0475 0.2393
Echinococcus granulosus titin 0.0078 0.0107 0.0062
Echinococcus multilocularis dual specificity protein kinase clk2 0.0168 0.0605 0.0589
Echinococcus granulosus Glutaredoxin protein 5 0.01 0.0229 0.0185
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0419 0.1992 0.1956
Entamoeba histolytica PH domain containing protein kinase, putative 0.0135 0.0422 0.0664
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.046 0.2221 0.2208
Trichomonas vaginalis AGC family protein kinase 0.0102 0.0239 0.0369
Echinococcus multilocularis Glutaredoxin protein 5 0.01 0.0229 0.0213
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0027 0.0025
Toxoplasma gondii casein kinase I 0.0121 0.0345 0.2906
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0283 0.1242 0.1288
Brugia malayi ephrin receptor 1 precursor 0.0079 0.0111 0.0115
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0236 0.0364
Echinococcus granulosus serine:threonine kinase SAD 1 0.0101 0.0234 0.019
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0228 0.0236
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0101 0.0234 0.0243
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0101 0.0234 0.0232
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0188 0.0712 0.1133
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0168 0.0605 0.0616
Brugia malayi Protein kinase domain containing protein 0.01 0.0228 0.0236
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0198 0.0187
Echinococcus granulosus serine:threonine protein kinase 12 B 0.016 0.0558 0.0515
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0027 0.0025
Brugia malayi Protein kinase domain containing protein 0.0179 0.0665 0.0689
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0101 0.0234 0.0232
Echinococcus granulosus peroxidasin 0.0106 0.0262 0.0218
Schistosoma mansoni serine/threonine protein kinase 0.0375 0.1752 0.1742
Echinococcus multilocularis c src tyrosine kinase 0.0136 0.0427 0.0411
Echinococcus multilocularis epidermal growth factor receptor 0.0636 0.3195 0.3184
Trichomonas vaginalis CAMK family protein kinase 0.0234 0.097 0.1549
Loa Loa (eye worm) phosphatidylinositol 3 0.0349 0.1604 0.1663
Echinococcus granulosus dual specificity 0.0153 0.052 0.0477
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0419 0.1992 0.1978
Echinococcus multilocularis rho associated protein kinase 0.0347 0.1593 0.1579
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0152 0.0515 0.0523
Schistosoma mansoni protein kinase 0.0075 0.009 0.0079
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0113 0.03 0.4123
Schistosoma mansoni kinase 0.0309 0.1383 0.1374
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0234 0.036
Plasmodium falciparum NIMA related kinase 1 0.015 0.0504 0.7027
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0116 0.0319 0.0303
Echinococcus multilocularis serine:threonine protein kinase 3 0.0276 0.12 0.1185
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0219 0.0887 0.0872
Trichomonas vaginalis CMGC family protein kinase 0.0095 0.0201 0.0308
Loa Loa (eye worm) AUR protein kinase 0.016 0.0558 0.0578
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.0495 0.0484
Toxoplasma gondii aurora kinase 0.016 0.0558 0.4753
Echinococcus granulosus dual specificity protein kinase clk2 0.0168 0.0605 0.0562
Echinococcus granulosus tyrosine protein kinase ABL1 0.01 0.0228 0.0184
Loa Loa (eye worm) hypothetical protein 0.0093 0.0189 0.0196
Echinococcus granulosus twitchin 0.0138 0.0441 0.0398
Echinococcus granulosus serine:threonine protein kinase PLK1 0.029 0.1277 0.1238
Loa Loa (eye worm) TK protein kinase 0.0297 0.1319 0.1368
Brugia malayi phosphoinositide-dependent protein kinase I 0.0093 0.0188 0.0195
Entamoeba histolytica protein kinase, putative 0.0082 0.0127 0.0188
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0153 0.052 0.0539
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.0606 0.0596
Echinococcus granulosus calcium dependent protein kinase 0.0071 0.0066 0.0021
Brugia malayi casein kinase I 0.0121 0.0345 0.0358
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0197 0.0765 0.0749
Brugia malayi Protein kinase domain containing protein 0.0217 0.0876 0.0908
Schistosoma mansoni ste20-related kinase 0.0222 0.0901 0.0891
Loa Loa (eye worm) AGC/PKA protein kinase 0.0126 0.037 0.0384
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0095 0.0201 0.0198
Schistosoma mansoni hypothetical protein 0.0106 0.0262 0.0251
Brugia malayi Fes/CIP4 homology domain containing protein 0.0115 0.0311 0.0322
Echinococcus multilocularis cyclin dependent kinase 9 0.0095 0.0199 0.0183
Onchocerca volvulus 0.01 0.0228 0.1023
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.01 0.0229 0.0185
Echinococcus multilocularis tyrosine protein kinase ABL1 0.01 0.0228 0.0212
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0098 0.0215 0.0171
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0027 0.0025
Loa Loa (eye worm) TK/ALK protein kinase 0.0294 0.1301 0.1348
Brugia malayi Protein kinase domain containing protein 0.0102 0.0236 0.0245
Echinococcus granulosus roundabout 2 0.0128 0.038 0.0337
Onchocerca volvulus 0.0142 0.0461 0.2314
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0096 0.0207 0.0214
Schistosoma mansoni hypothetical protein 0.0116 0.0319 0.0308
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0153 0.052 0.4426
Entamoeba histolytica protein kinase, putative 0.0084 0.0141 0.021
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0143 0.0463 0.042
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0142 0.0461 0.0467
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.01 0.0229 0.0213
Onchocerca volvulus Serine\/threonine kinase homolog 0.0179 0.0665 0.3447
Echinococcus granulosus casein kinase I delta 0.0121 0.0345 0.0302
Loa Loa (eye worm) hypothetical protein 0.0101 0.0234 0.0243
Onchocerca volvulus Serine\/threonine kinase homolog 0.029 0.1277 0.6846
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0242 0.1012 0.0971
Trichomonas vaginalis STE family protein kinase 0.015 0.0504 0.0796
Trichomonas vaginalis CAMK family protein kinase 0.014 0.0447 0.0705
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0095 0.0198 0.0194
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0296 0.046
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.037 0.036
Entamoeba histolytica protein kinase, putative 0.0135 0.0424 0.0666
Echinococcus granulosus serine:threonine protein kinase 3 0.0276 0.12 0.116
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0178 0.0167
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.0404 0.0394
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0137 0.0433 0.0389
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1179 0.6199 0.6426
Trypanosoma cruzi cdc2-related kinase 3 0.0137 0.0433 0.0437
Echinococcus multilocularis 0.0181 0.0676 0.066
Echinococcus granulosus dual specificity 0.0153 0.052 0.0477
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0296 0.046
Trichomonas vaginalis AGC family protein kinase 0.016 0.0558 0.0883
Loa Loa (eye worm) TK/ABL protein kinase 0.01 0.0228 0.0236
Loa Loa (eye worm) hypothetical protein 0.015 0.0502 0.0521
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0391 0.184 0.1898
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0168 0.0605 0.5162
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0137 0.0433 0.0448
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0027 0.0025
Schistosoma mansoni protein kinase 0.0112 0.0296 0.0285
Echinococcus multilocularis tyrosine protein kinase Abl 0.0136 0.0427 0.0411
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0188 0.0712 0.067
Echinococcus granulosus dual specificity 0.0135 0.0424 0.038
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0228 0.0236
Trichomonas vaginalis CK1 family protein kinase 0.0121 0.0345 0.054
Loa Loa (eye worm) AGC/PKG protein kinase 0.0148 0.0495 0.0513
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0496 0.0486
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0197 0.0765 0.0749
Entamoeba histolytica serine/threonine protein kinase, putative 0.029 0.1277 0.2046
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0093 0.019 0.0197
Entamoeba histolytica protein kinase, putative 0.0135 0.0424 0.0666
Echinococcus multilocularis ephrin type A receptor 4 A 0.0114 0.0306 0.029
Echinococcus multilocularis serine:threonine protein kinase N2 0.0135 0.0422 0.0406
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0148 0.0495 0.0479
Echinococcus granulosus casein kinase I alpha 0.0121 0.0345 0.0302
Plasmodium falciparum cGMP-dependent protein kinase 0.0148 0.0495 0.6899
Trypanosoma cruzi casein kinase, putative 0.0121 0.0345 0.0347
Loa Loa (eye worm) hypothetical protein 0.0369 0.1715 0.1778
Brugia malayi Protein kinase domain containing protein 0.0294 0.1301 0.1349
Echinococcus granulosus calcium activated potassium channel 0.0149 0.0496 0.0453
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0112 0.0296 0.0307
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0296 0.046
Trichomonas vaginalis AGC family protein kinase 0.0278 0.1212 0.1941
Trichomonas vaginalis CAMK family protein kinase 0.014 0.0447 0.0705
Echinococcus granulosus cGMP dependent protein kinase 0.0148 0.0495 0.0452
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0633 0.3178 0.3295
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0416 0.1977 0.1964
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0188 0.0712 0.6097
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.009 0.0171 0.0166
Echinococcus multilocularis CDC7 cell division cycle 7 0.0102 0.0236 0.022
Schistosoma mansoni protein kinase 0.039 0.1833 0.1824
Brugia malayi Doublecortin family protein 0.0165 0.0588 0.061
Echinococcus granulosus tyrosine protein kinase Fyn 0.0197 0.0765 0.0723
Schistosoma mansoni nck2/grb4 0.0088 0.0164 0.0153
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0236 0.0364
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0296 0.046
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0113 0.03 0.0311
Plasmodium falciparum serine/threonine protein kinase, putative 0.016 0.0558 0.7795
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0234 0.036
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0234 0.036
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.1802 0.9646 1
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0234 0.0223
Echinococcus granulosus serine:threonine protein kinase N2 0.0303 0.1354 0.1315
Trichomonas vaginalis AGC family protein kinase 0.0278 0.1212 0.1941
Loa Loa (eye worm) CAMK protein kinase 0.0078 0.0107 0.0111
Echinococcus multilocularis Immunoglobulin 0.0077 0.0099 0.0082
Echinococcus multilocularis serine:threonine protein kinase 0.0127 0.0377 0.0361
Loa Loa (eye worm) hypothetical protein 0.025 0.1057 0.1096
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0121 0.0345 0.0347
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0126 0.037 0.0373
Entamoeba histolytica protein kinase, putative 0.0153 0.052 0.0822
Echinococcus multilocularis activin receptor type 0.009 0.0171 0.0155
Onchocerca volvulus 0.01 0.0228 0.1023
Loa Loa (eye worm) CDC7 protein kinase 0.0102 0.0236 0.0245
Onchocerca volvulus 0.01 0.0228 0.1023
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0496 0.0486
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0101 0.0234 0.0232
Brugia malayi Serine/threonine-protein kinase SULU 0.024 0.1 0.1037
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0142 0.0461 0.0418
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0687 0.3476 0.3604
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0113 0.03 0.0256
Brugia malayi Protein kinase domain containing protein 0.0137 0.0433 0.0448
Echinococcus multilocularis tyrosine protein kinase 0.0297 0.1319 0.1305
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0034 0.0023
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0202 0.079 0.0775
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0375 0.1752 0.1816
Onchocerca volvulus 0.0149 0.0498 0.2522
Echinococcus granulosus cyclin dependent kinase 9 0.0095 0.0199 0.0155
Brugia malayi intracellular kinase 0.0142 0.0461 0.0478
Schistosoma mansoni tyrosine kinase 0.0197 0.0765 0.0754
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0082 0.0127 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.0605 0.0594
Brugia malayi Protein kinase domain 0.0098 0.0215 0.0223
Schistosoma mansoni protein kinase 0.0284 0.1246 0.1236
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0168 0.0606 0.0564
Brugia malayi Protein kinase domain containing protein 0.01 0.0228 0.0236
Leishmania major protein kinase, putative 0.009 0.0171 0.0166
Brugia malayi hypothetical protein 0.024 0.1 0.1037
Trypanosoma cruzi Protein kinase B 0.0152 0.0515 0.0523
Trypanosoma cruzi cdc2-related kinase 1 0.0137 0.0433 0.0437
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0096 0.0207 0.019
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0078 0.0108
Echinococcus multilocularis neuroglian 0.0096 0.0207 0.019
Trichomonas vaginalis CAMK family protein kinase 0.029 0.1277 0.2046
Loa Loa (eye worm) protein kinase domain-containing protein 0.023 0.0948 0.0983
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0444 0.2133 0.2125
Onchocerca volvulus 0.0202 0.0791 0.4147
Leishmania major protein kinase, putative 0.0168 0.0605 0.0616
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0128 0.0382 0.0339
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0433 0.0681
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0153 0.052 0.0539
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0126 0.037 0.0373
Echinococcus granulosus cyclin dependent kinase 0.0137 0.0433 0.0389
Echinococcus granulosus aurora kinase A 0.016 0.0558 0.0515
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0126 0.037 0.3125
Echinococcus multilocularis death associated protein kinase 1 0.0892 0.461 0.4601
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0116 0.0315 0.0299
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0078 0.0108
Brugia malayi Variant SH3 domain containing protein 0.0064 0.003 0.0031
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0027 0.0025
Schistosoma mansoni tyrosine kinase 0.0467 0.2258 0.2249
Loa Loa (eye worm) hypothetical protein 0.0145 0.0475 0.0492
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0252 0.1068 0.1053
Echinococcus granulosus serine:threonine protein kinase TAO1 0.024 0.1 0.0959
Loa Loa (eye worm) hypothetical protein 0.0188 0.0716 0.0742
Loa Loa (eye worm) hypothetical protein 0.0095 0.0198 0.0206
Giardia lamblia Kinase, AGC AKT 0.013 0.0394 0.1149
Trypanosoma cruzi polo-like protein kinase, putative 0.029 0.1277 0.1314
Echinococcus granulosus mitogen activated protein kinase 14 0.1802 0.9646 0.9644
Brugia malayi serine/threonine-protein kinase 6 0.016 0.0558 0.0578
Loa Loa (eye worm) AGC/PKA protein kinase 0.0126 0.037 0.0384
Onchocerca volvulus 0.0102 0.0236 0.1069
Trypanosoma brucei casein kinase I, isoform 2 0.0121 0.0345 0.0347
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0188 0.0712 0.067
Onchocerca volvulus 0.01 0.0228 0.1023
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0349 0.1604 0.1654
Onchocerca volvulus 0.0347 0.1593 0.8602
Onchocerca volvulus 0.0121 0.0345 0.1674
Entamoeba histolytica protein kinase domain containing protein 0.016 0.0558 0.0883
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0254 0.108 0.1065
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0116 0.0319 0.0319
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0219 0.0887 0.092
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0093 0.0188 0.0144
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0234 0.036
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0093 0.0188 0.0195
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.039 0.1833 0.1797
Echinococcus multilocularis mitogen activated protein kinase 11 0.1802 0.9646 0.9645
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0753 0.3842 0.3814
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0496 0.0486
Schistosoma mansoni serine/threonine protein kinase 0.029 0.1277 0.1267
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0414 0.1965 0.1929
Schistosoma mansoni protein kinase 0.0252 0.1068 0.1058
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0095 0.0201 0.0209
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0116 0.0319 0.0308
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0086 0.015 0.0156
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.0887 0.0877
Brugia malayi Protein kinase domain containing protein 0.01 0.0228 0.0236
Entamoeba histolytica casein kinase 1, putative 0.0121 0.0345 0.054
Schistosoma mansoni protein kinase 0.046 0.2221 0.2212
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0391 0.184 0.1898
Brugia malayi Protein kinase domain containing protein 0.0633 0.3178 0.3295
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0078 0.0108
Brugia malayi Protein kinase domain containing protein 0.0467 0.2258 0.234
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0137 0.0433 0.0448
Echinococcus multilocularis peroxidasin 0.0106 0.0262 0.0245
Echinococcus granulosus tyrosine kinase 0.0161 0.0566 0.0524
Brugia malayi RhoGAP domain containing protein 0.0096 0.0207 0.0214
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0197 0.0765 0.0723
Loa Loa (eye worm) TK/INSR protein kinase 0.0467 0.2258 0.234
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0179 0.0665 0.0689
Echinococcus granulosus protein kinase c epsilon type 0.0214 0.086 0.0819
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0095 0.0198 0.0205
Entamoeba histolytica casein kinase, putative 0.0112 0.0296 0.046
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.0876 0.0866
Trypanosoma cruzi cdc2-related kinase 1 0.0137 0.0433 0.0437
Plasmodium falciparum protein serine/threonine kinase-1 0.0168 0.0605 0.8466
Loa Loa (eye worm) hypothetical protein 0.0071 0.0068 0.0071
Entamoeba histolytica hypothetical protein 0.0975 0.5071 0.8177
Schistosoma mansoni protein kinase 0.0252 0.1068 0.1058
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0095 0.0201 0.0198
Echinococcus granulosus CDC7 cell division cycle 7 0.0102 0.0236 0.0192
Brugia malayi MAP kinase sur-1 0.0095 0.0201 0.0209
Loa Loa (eye worm) hypothetical protein 0.0126 0.037 0.0384
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0027 0.0025
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0067 0.0045 0.0028
Loa Loa (eye worm) AGC/PKN protein kinase 0.0303 0.1354 0.1403
Echinococcus granulosus serine threonine protein kinase nrc 0.0143 0.0463 0.042
Echinococcus multilocularis casein kinase I delta 0.0121 0.0345 0.0329
Loa Loa (eye worm) TK/EPH protein kinase 0.0132 0.0407 0.0422
Brugia malayi Protein kinase domain containing protein 0.0234 0.097 0.1005
Echinococcus multilocularis tyrosine protein kinase Srms 0.0161 0.0566 0.055
Echinococcus multilocularis casein kinase I gamma 0.023 0.0948 0.0933
Schistosoma mansoni atypical protein kinase C 0.0305 0.136 0.1351
Plasmodium falciparum calcium-dependent protein kinase 3 0.0113 0.03 0.4123
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0188 0.0712 0.1133
Entamoeba histolytica hypothetical protein 0.0135 0.0424 0.0666
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1866 1 1
Plasmodium falciparum serine/threonine protein kinase 0.0095 0.0198 0.2664
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0098 0.0215 0.0198
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0253 0.1074 0.1033
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0027 0.0025
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0121 0.0345 0.0358
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0228 0.0236
Schistosoma mansoni protein kinase 0.0098 0.0215 0.0204
Giardia lamblia Kinase, AGC PKA 0.0126 0.037 0.1079
Brugia malayi Protein kinase domain containing protein 0.0297 0.1319 0.1368
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0095 0.0201 0.0198
Onchocerca volvulus 0.008 0.0119 0.0418
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0078 0.0108
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0153 0.052 0.0528
Echinococcus granulosus tyrosine protein kinase 0.0297 0.1319 0.128
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0168 0.0605 0.0616
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0219 0.0887 0.092
Brugia malayi Protein kinase domain containing protein 0.0168 0.0606 0.0628
Echinococcus granulosus protein tyrosine kinase 0.0575 0.2855 0.2823
Schistosoma mansoni protein kinase 0.009 0.0171 0.016
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0127 0.0116
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0135 0.0424 0.0428
Brugia malayi Protein kinase domain containing protein 0.099 0.515 0.5339
Onchocerca volvulus Chorion peroxidase homolog 0.0071 0.0068 0.0137
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.009 0.0171 0.1392
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0199 0.0188
Entamoeba histolytica protein kinase, putative 0.0093 0.0188 0.0287
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0101 0.0234 0.0232
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0113 0.03 0.0284
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0375 0.1752 0.1816
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0179 0.0663 0.0687
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.03 0.0467
Echinococcus granulosus cyclin dependent kinase 5 0.0137 0.0433 0.0389
Trichomonas vaginalis AGC family protein kinase 0.016 0.0558 0.0883
Echinococcus granulosus cGMP dependent protein kinase 1 0.0148 0.0495 0.0452
Echinococcus multilocularis aurora kinase A 0.016 0.0558 0.0542
Trichomonas vaginalis AGC family protein kinase 0.0278 0.1212 0.1941
Loa Loa (eye worm) hypothetical protein 0.0149 0.0498 0.0516
Plasmodium falciparum casein kinase 2, alpha subunit 0.0112 0.0296 0.4063
Loa Loa (eye worm) hypothetical protein 0.0126 0.037 0.0384
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0065 0.0034 0.0024
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0202 0.079 0.0819
Onchocerca volvulus Peroxidasin homolog 0.0091 0.0178 0.0745
Brugia malayi protein unc-22 0.0078 0.0107 0.0111
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0098 0.0215 0.0171
Leishmania major protein kinase A catalytic subunit isoform 1 0.0126 0.037 0.0373
Trichomonas vaginalis STE family protein kinase 0.0098 0.0215 0.0329
Echinococcus granulosus protein kinase C gamma type 0.0212 0.0847 0.0806
Giardia lamblia Kinase, NEK 0.015 0.0504 0.1479
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0234 0.036
Echinococcus granulosus tyrosine protein kinase Fyn 0.0197 0.0765 0.0723
Brugia malayi cell division control protein 2 homolog 0.0137 0.0433 0.0448
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0126 0.037 0.0354
Loa Loa (eye worm) SRC-1 0.0197 0.0765 0.0793
Loa Loa (eye worm) hypothetical protein 0.0106 0.0262 0.0272
Schistosoma mansoni tyrosine kinase 0.0082 0.0128 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0345 0.0334
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0126 0.037 0.0373
Brugia malayi Immunoglobulin I-set domain containing protein 0.0078 0.0107 0.0111
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0112 0.0296 0.4063
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0113 0.03 0.0284
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0168 0.0605 0.0616
Trichomonas vaginalis AGC family protein kinase 0.0126 0.037 0.0581
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.1802 0.9646 1
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0078 0.0108
Brugia malayi Protein kinase domain containing protein 0.01 0.0228 0.0236
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0168 0.0602 0.0624
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0113 0.03 0.0311
Entamoeba histolytica protein kinase, putative 0.0142 0.0461 0.0726
Trichomonas vaginalis AGC family protein kinase 0.019 0.0724 0.1152
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0228 0.0236
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.05 0.2442 0.3928
Echinococcus granulosus tyrosine protein kinase Src42A 0.0197 0.0765 0.0723
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0096 0.0207 0.0196
Onchocerca volvulus Peroxidase homolog 0.0071 0.0068 0.0137
Echinococcus multilocularis casein kinase I alpha 0.0121 0.0345 0.0329
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.016 0.0558 0.0542
Loa Loa (eye worm) hypothetical protein 0.0062 0.0017 0.0018
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0093 0.0188 0.0172
Schistosoma mansoni peroxidasin 0.0087 0.0154 0.0143
Plasmodium vivax serine/threonine kinase-1, putative 0.0168 0.0605 0.8466
Loa Loa (eye worm) hypothetical protein 0.0145 0.0475 0.0492
Echinococcus multilocularis growth factor receptor bound protein 2 0.0088 0.0164 0.0148
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.0665 0.0654
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0168 0.0606 0.0564
Loa Loa (eye worm) AGC/AKT protein kinase 0.0278 0.1212 0.1257
Schistosoma mansoni tyrosine kinase 0.0372 0.1732 0.1723
Schistosoma mansoni serine/threonine protein kinase 0.0253 0.1074 0.1064
Loa Loa (eye worm) hypothetical protein 0.0071 0.0068 0.0071
Echinococcus multilocularis raf serine:threonine protein kinase 0.0091 0.0178 0.0162
Echinococcus multilocularis casein kinase I delta 0.0121 0.0345 0.0329
Onchocerca volvulus 0.01 0.0228 0.1023
Schistosoma mansoni rap gtpase-activating protein 0.0116 0.0319 0.0308
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0161 0.0566 0.0524
Loa Loa (eye worm) blistered cuticle protein 3 0.0071 0.0068 0.0071
Toxoplasma gondii histone kinase SNF1, putative 0.0101 0.0234 0.194
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0092 0.0186 0.2492
Echinococcus granulosus rho-associated protein kinase 1 0.0347 0.1593 0.1556
Toxoplasma gondii AGC kinase 0.0269 0.1161 1
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0228 0.0236
Echinococcus multilocularis nervana 2 0.01 0.0229 0.0213
Trichomonas vaginalis STE family protein kinase 0.0098 0.0215 0.0329
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0126 0.037 0.0354
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0095 0.0201 0.0198
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0082 0.0127 0.0083
Echinococcus multilocularis 0.0168 0.0602 0.0586
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0757 0.3863 0.4005
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0353 0.1629 0.1689
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0096 0.0207 0.0203
Entamoeba histolytica protein kinase, putative 0.0269 0.1161 0.1858
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0197 0.0765 0.0749
Echinococcus granulosus casein kinase ii subunit alpha 0.0112 0.0296 0.0252
Trichomonas vaginalis CAMK family protein kinase 0.029 0.1277 0.2046
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0078 0.0108
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0159 0.0553 0.051
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0027 0.0025
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0419 0.1992 0.2065
Trichomonas vaginalis STE family protein kinase 0.0098 0.0215 0.0329
Entamoeba histolytica p21-activated kinase 0.0107 0.0266 0.0412
Giardia lamblia Kinase, STE STE20 0.0096 0.0207 0.0588
Leishmania major protein kinase A catalytic subunit isoform 2 0.0126 0.037 0.0373
Onchocerca volvulus 0.0192 0.0739 0.3861
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0126 0.037 0.0327
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0234 0.036
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.019 0.0724 0.0751
Plasmodium falciparum casein kinase 1 0.0121 0.0345 0.4766
Echinococcus multilocularis epidermal growth factor receptor 0.0419 0.1995 0.1981
Entamoeba histolytica protein kinase, putative 0.0278 0.1212 0.1941
Brugia malayi Protein kinase domain containing protein 0.0475 0.2305 0.239
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.052 0.0822
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1179 0.6199 1
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0375 0.1752 0.1738
Entamoeba histolytica protein kinase, putative 0.0278 0.1212 0.1941
Brugia malayi Furin-like cysteine rich region family protein 0.0636 0.3195 0.3312
Loa Loa (eye worm) hypothetical protein 0.0124 0.036 0.0374
Schistosoma mansoni serine/threonine protein kinase 0.0214 0.086 0.085
Loa Loa (eye worm) hypothetical protein 0.0071 0.0068 0.0071
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1802 0.9646 1
Trypanosoma brucei cdc2-related kinase 1 0.0137 0.0433 0.0437
Echinococcus multilocularis cyclin dependent kinase 5 0.0137 0.0433 0.0417
Echinococcus multilocularis casein kinase I alpha 0.0121 0.0345 0.0329
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.0316 0.0306
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0234 0.036
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.016 0.0558 0.0883
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.1089 0.1079
Echinococcus granulosus casein kinase I alpha 0.0121 0.0345 0.0302
Trichomonas vaginalis serine/threonine-protein kinase ypk, putative 0.0064 0.0027 0.0025
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0228 0.0236
Echinococcus multilocularis calcium dependent protein kinase 0.0071 0.0066 0.0049
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0391 0.184 0.2956
Loa Loa (eye worm) hypothetical protein 0.0071 0.0068 0.0071
Echinococcus multilocularis expressed conserved protein 0.0148 0.0495 0.0479
Entamoeba histolytica protein kinase domain containing protein 0.0219 0.0887 0.1416
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0159 0.0554 0.0511
Entamoeba histolytica protein kinase, putative 0.0168 0.0606 0.0962
Schistosoma mansoni serine/threonine protein kinase 0.0347 0.1593 0.1584
Plasmodium vivax unspecified product 0.0112 0.0296 0.4063
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1179 0.6199 0.6422
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0234 0.036
Entamoeba histolytica protein kinase, putative 0.0109 0.0275 0.0427
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0142 0.0461 0.0467
Echinococcus multilocularis titin 0.0078 0.0107 0.009
Schistosoma mansoni protein kinase 0.046 0.2221 0.2212
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0234 0.036
Echinococcus granulosus nervana 2 0.01 0.0229 0.0185
Entamoeba histolytica protein kinase, putative 0.0115 0.0313 0.0488
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.052 0.0822
Schistosoma mansoni vam6/vps39 related 0.0116 0.0319 0.0308
Trichomonas vaginalis STE family protein kinase 0.0075 0.009 0.0127
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0165 0.0588 0.061
Echinococcus granulosus casein kinase I alpha 0.0121 0.0345 0.0302
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0296 0.046
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0027 0.0025
Loa Loa (eye worm) hypothetical protein 0.0085 0.0144 0.015
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0252 0.1068 0.1027
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0256 0.1091 0.1076
Echinococcus multilocularis mitogen activated protein kinase 14 0.1802 0.9646 0.9645
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0416 0.1977 0.1941
Echinococcus granulosus cyclin dependent kinase 9 0.0104 0.025 0.0206
Loa Loa (eye worm) TK/FAK protein kinase 0.0581 0.289 0.2996
Brugia malayi Protein kinase domain containing protein 0.0072 0.0075 0.0078
Brugia malayi Variant SH3 domain containing protein 0.0096 0.0207 0.0214
Entamoeba histolytica PH domain containing protein kinase, putative 0.0152 0.0515 0.0814
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0065 0.0034 0.0035
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0188 0.0712 0.0728
Echinococcus granulosus c src tyrosine kinase 0.0136 0.0427 0.0383
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0523 0.2569 0.2557
Trichomonas vaginalis CMGC family protein kinase 0.0095 0.0201 0.0308
Onchocerca volvulus Tyrosine kinase homolog 0.0392 0.1845 1
Schistosoma mansoni tyrosine kinase 0.0254 0.108 0.107
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0126 0.037 0.0354
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0137 0.0433 0.0437
Plasmodium falciparum calcium-dependent protein kinase 1 0.0113 0.03 0.4123
Schistosoma mansoni protein kinase 0.046 0.2221 0.2212
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.025 0.1057 0.1096
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0296 0.046
Brugia malayi Protein kinase domain containing protein 0.0095 0.0198 0.0205
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1179 0.6199 0.6422
Brugia malayi Hr1 repeat family protein 0.0303 0.1354 0.1403
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0113 0.03 0.2514
Schistosoma mansoni protein kinase 0.0168 0.0602 0.0591
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0142 0.0461 0.0445
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0235 0.0973 0.1009
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.1802 0.9646 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0146 0.0484 0.0763
Brugia malayi SH2 domain containing protein 0.01 0.0228 0.0236
Brugia malayi hypothetical protein 0.01 0.0228 0.0236
Entamoeba histolytica SH2-protein kinase domain containing protein 0.01 0.0228 0.035
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0391 0.184 0.1908
Loa Loa (eye worm) hypothetical protein 0.0071 0.0068 0.0071
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0197 0.0765 0.0749
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0113 0.03 0.4123
Giardia lamblia Kinase, CMGC GSK 0.0142 0.0461 0.135
Plasmodium vivax glycogen synthase kinase 3, putative 0.0142 0.0461 0.6412
Echinococcus multilocularis protein kinase c iota type 0.0298 0.1325 0.1311
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0483 0.2348 0.2335
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0382 0.06
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0078 0.0108
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.03 0.0289
Giardia lamblia Kinase, CMGC GSK 0.0142 0.0461 0.135
Onchocerca volvulus 0.01 0.0228 0.1023
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0143 0.0463 0.0469
Loa Loa (eye worm) TK/EGFR protein kinase 0.0636 0.3195 0.3312
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0375 0.1752 0.1714
Entamoeba histolytica protein kinase, putative 0.0082 0.0127 0.0188
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0065 0.0034 0.0035
Echinococcus granulosus insulin receptor 0.0467 0.2258 0.2223
Entamoeba histolytica PH domain containing protein kinase, putative 0.0152 0.0515 0.0814
Schistosoma mansoni protein kinase 0.0098 0.0215 0.0204
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0236 0.0364
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0143 0.0463 0.6451
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0523 0.2569 0.2536
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0135 0.0424 0.0428
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0121 0.0345 0.0358
Brugia malayi Immunoglobulin I-set domain containing protein 0.0093 0.0189 0.0196
Trichomonas vaginalis CAMK family protein kinase 0.029 0.1277 0.2046
Echinococcus granulosus Vam6:Vps39 protein 0.0116 0.0319 0.0275
Leishmania major protein kinase, putative 0.0168 0.0605 0.0616
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0102 0.0239 0.0248
Echinococcus multilocularis dual specificity 0.0135 0.0424 0.0408
Schistosoma mansoni serine/threonine-protein kinase 0.0152 0.0515 0.0504
Schistosoma mansoni growth factor receptor-bound protein 0.0088 0.0164 0.0153
Plasmodium falciparum calcium-dependent protein kinase 2 0.0113 0.03 0.4123
Loa Loa (eye worm) hypothetical protein 0.0093 0.0189 0.0196
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0137 0.0433 0.0437
Echinococcus granulosus epidermal growth factor receptor 0.0636 0.3195 0.3164
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0116 0.0319 0.0319
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.046 0.2221 0.2186
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0201 0.0191
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0092 0.0182 0.0138
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0121 0.0345 0.0358
Giardia lamblia Aurora kinase 0.016 0.0558 0.1641
Schistosoma mansoni tyrosine kinase 0.0372 0.1732 0.1723
Brugia malayi Tyrosine-protein kinase abl-1 0.0136 0.0427 0.0442
Trichomonas vaginalis AGC family protein kinase 0.0199 0.0776 0.1236
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0441 0.2112 0.3396
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0168 0.0605 0.0616
Brugia malayi C1-like domain containing protein 0.0235 0.0973 0.1009
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0078 0.0108
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0073 0.0078 0.0108
Trichomonas vaginalis STE family protein kinase 0.0096 0.0207 0.0316
Trichomonas vaginalis STE family protein kinase 0.0098 0.0215 0.0329
Echinococcus multilocularis serine:threonine protein kinase 38 0.0168 0.0606 0.0591
Loa Loa (eye worm) AUR protein kinase 0.016 0.0558 0.0578
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0142 0.0461 0.0478
Trypanosoma brucei cdc2-related kinase 3 0.0137 0.0433 0.0437
Loa Loa (eye worm) hypothetical protein 0.0071 0.0068 0.0071
Loa Loa (eye worm) hypothetical protein 0.0071 0.0068 0.0071
Brugia malayi STE20-like kinase MST 0.0276 0.12 0.1244
Loa Loa (eye worm) hypothetical protein 0.0071 0.0068 0.0071
Trichomonas vaginalis CAMK family protein kinase 0.0299 0.1328 0.2128
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.015 0.0504 0.4284
Loa Loa (eye worm) hypothetical protein 0.0111 0.029 0.0301
Giardia lamblia Kinase, PLK 0.029 0.1277 0.3802
Echinococcus multilocularis serine threonine protein kinase 0.0212 0.0847 0.0832
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0027 0.0025
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0209 0.083 0.0861
Schistosoma mansoni adapter molecule crk 0.0088 0.0164 0.0153
Echinococcus multilocularis cyclin dependent kinase 1 0.0137 0.0433 0.0417
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0027 0.0025
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0347 0.1595 0.1654
Entamoeba histolytica protein kinase, putative 0.0113 0.03 0.0467
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0096 0.0207 0.0203
Loa Loa (eye worm) TK/ROR protein kinase 0.0067 0.0045 0.0047
Trypanosoma brucei SNF1-related protein kinases, putative 0.0101 0.0234 0.0232
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.052 0.0822
Echinococcus multilocularis cyclin dependent kinase 9 0.0104 0.025 0.0234
Trichomonas vaginalis CAMK family protein kinase 0.0127 0.0377 0.0591
Leishmania major protein kinase A catalytic subunit 0.0126 0.037 0.0373
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0135 0.0424 0.0439
Trichomonas vaginalis serine/threonine-protein kinase, putative 0.0064 0.0027 0.0025
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.015 0.0504 0.7027
Schistosoma mansoni tyrosine kinase 0.0467 0.2258 0.2249
Trichomonas vaginalis CK1 family protein kinase 0.0121 0.0345 0.054
Schistosoma mansoni tyrosine kinase 0.0136 0.0427 0.0416
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0083 0.0136 0.012
Schistosoma mansoni serine/threonine protein kinase 0.0135 0.0424 0.0413
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0137 0.0433 0.3666
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0168 0.0605 0.0616
Echinococcus granulosus NDR protein kinase 0.0168 0.0606 0.0564
Brugia malayi cyclin-dependent kinase 7 homolog 0.0141 0.0455 0.0472
Onchocerca volvulus 0.0304 0.1359 0.7302
Echinococcus multilocularis serine:threonine protein kinase N2 0.0168 0.0606 0.0591
Schistosoma mansoni ephrin receptor 0.0114 0.0306 0.0295
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0254 0.108 0.104
Echinococcus granulosus mitogen activated protein kinase 0.0095 0.0201 0.0157
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0188 0.0712 0.0728
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.1137 0.5963 0.9619
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0234 0.036
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0126 0.037 0.0373
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0113 0.03 0.2514
Schistosoma mansoni peroxidasin 0.0071 0.0068 0.0057
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0217 0.0876 0.0908
Echinococcus granulosus N chimaerin 0.0096 0.0207 0.0163
Echinococcus multilocularis mitogen activated protein kinase 14 0.1802 0.9646 0.9645
Brugia malayi serine/threonine-protein kinase PAK 7 0.025 0.1057 0.1096
Echinococcus granulosus tyrosine protein kinase Src42A 0.0116 0.0315 0.0272
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0191 0.0732 0.0759
Echinococcus multilocularis dual specificity 0.0153 0.052 0.0504
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0142 0.0461 0.0478
Echinococcus multilocularis nervana 2 0.01 0.0229 0.0213
Brugia malayi Protein kinase domain containing protein 0.0278 0.1212 0.1257
Loa Loa (eye worm) hypothetical protein 0.0113 0.03 0.0311
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0188 0.0712 1
Onchocerca volvulus Peroxidase homolog 0.0071 0.0068 0.0137
Loa Loa (eye worm) animal heme peroxidase 0.0071 0.0068 0.0071
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.029 0.1277 0.1324
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0233 0.0964 0.0923
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0078 0.0108
Echinococcus multilocularis tyrosine protein kinase HCK 0.0109 0.0275 0.0259
Brugia malayi p70 ribosomal S6 kinase beta 0.0269 0.1161 0.1203
Plasmodium falciparum calcium-dependent protein kinase 4 0.0113 0.03 0.4123
Schistosoma mansoni serine/threonine protein kinase 0.016 0.0558 0.0547
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0113 0.03 0.0311
Echinococcus granulosus casein kinase I delta 0.0121 0.0345 0.0302
Onchocerca volvulus 0.0071 0.0068 0.0137
Trichomonas vaginalis AGC family protein kinase 0.015 0.0504 0.0796
Echinococcus multilocularis protein kinase c epsilon type 0.0214 0.086 0.0845
Brugia malayi Variant SH3 domain containing protein 0.0088 0.0164 0.017
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0633 0.3178 0.3295
Echinococcus multilocularis casein kinase ii subunit alpha 0.0112 0.0296 0.028
Brugia malayi SRC-1 0.0197 0.0765 0.0793
Leishmania major protein kinase, putative 0.016 0.0558 0.0567
Brugia malayi Animal haem peroxidase family protein 0.0091 0.0176 0.0183
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0233 0.0964 0.0949
Mycobacterium ulcerans hypothetical protein 0.0106 0.0261 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0433 0.0681
Echinococcus granulosus Immunoglobulin 0.0077 0.0099 0.0054
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.037 0.036
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0228 0.0236
Brugia malayi hypothetical protein 0.0116 0.0319 0.0331
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0375 0.1752 0.1816
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0027 0.0025
Trichomonas vaginalis CMGC family protein kinase 0.0095 0.0201 0.0308
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0137 0.0433 0.0448
Loa Loa (eye worm) casein kinase 0.0188 0.0714 0.074
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0188 0.0712 0.0702
Brugia malayi Animal haem peroxidase family protein 0.0071 0.0068 0.0071
Loa Loa (eye worm) AUR protein kinase 0.016 0.0558 0.0578
Toxoplasma gondii AGC kinase 0.0126 0.037 0.3125
Brugia malayi Animal haem peroxidase family protein 0.0071 0.0068 0.0071
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0179 0.0665 0.0623
Entamoeba histolytica protein kinase, putative 0.016 0.0558 0.0883
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0098 0.0215 0.0198
Brugia malayi Cam kinase protein 1 0.0113 0.03 0.0311
Onchocerca volvulus 0.0078 0.0107 0.0351
Loa Loa (eye worm) hypothetical protein 0.0753 0.3842 0.3983
Brugia malayi Kinase associated domain 1 family protein 0.0106 0.0262 0.0272
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0127 0.0377 0.039
Brugia malayi Temporarily assigned gene name protein 59 0.0134 0.0418 0.0434
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0027 0.0025
Schistosoma mansoni tyrosine kinase 0.008 0.0118 0.0107
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0116 0.0319 0.0275
Entamoeba histolytica protein kinase, putative 0.0075 0.009 0.0127
Schistosoma mansoni serine/threonine protein kinase 0.0137 0.0433 0.0422
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0082 0.0127 0.0111
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0113 0.03 0.0256
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0116 0.0319 0.0319
Echinococcus multilocularis casein kinase i 0.0121 0.0345 0.0329
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0219 0.0887 0.0846
Brugia malayi Protein kinase domain containing protein 0.0135 0.0424 0.0439
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0188 0.0712 0.0738
Trichomonas vaginalis AGC family protein kinase 0.0278 0.1212 0.1941
Schistosoma mansoni vav2 0.0105 0.0258 0.0247
Brugia malayi serine/threonine-protein kinase plk-2 0.029 0.1277 0.1324
Echinococcus granulosus expressed protein 0.0095 0.0198 0.0154
Loa Loa (eye worm) hypothetical protein 0.0192 0.0739 0.0766
Trypanosoma cruzi casein kinase, putative 0.0121 0.0345 0.0347
Brugia malayi Protein kinase c protein 2 0.013 0.0391 0.0406
Loa Loa (eye worm) hypothetical protein 0.0071 0.0068 0.0071
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0197 0.0765 0.0749
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0148 0.0495 0.0479
Brugia malayi hypothetical protein 0.0071 0.0068 0.0071
Plasmodium falciparum protein kinase, putative 0.009 0.0171 0.2282
Echinococcus granulosus defective proboscis extension response 0.0077 0.0099 0.0054
Echinococcus multilocularis dual specificity 0.0153 0.052 0.0504
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0027 0.0025
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0126 0.037 0.5125
Entamoeba histolytica protein kinase, putative 0.0095 0.0198 0.0302
Echinococcus multilocularis tyrosine protein kinase Blk 0.0161 0.0566 0.055
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0135 0.0424 0.0428
Schistosoma mansoni ephrin receptor 0.0064 0.0027 0.0016
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0179 0.0665 0.0649
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.079 0.078
Schistosoma mansoni protein kinase C mu 0.0235 0.0973 0.0963
Giardia lamblia Kinase, CAMK CAMKL 0.011 0.0285 0.0823
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0064 0.003 0.0031
Brugia malayi Protein kinase domain containing protein 0.0168 0.0605 0.0627
Echinococcus granulosus serine:threonine protein kinase N2 0.0135 0.0422 0.0379
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.0404 0.0394
Brugia malayi protein kinase C3,putative 0.0172 0.0628 0.0651
Brugia malayi Casein kinase II, alpha chain 0.0112 0.0296 0.0307
Giardia lamblia Kinase, STE STE20 0.0098 0.0215 0.0611
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.052 0.0822
Schistosoma mansoni tyrosine kinase 0.0197 0.0765 0.0754
Brugia malayi Protein kinase domain containing protein 0.0375 0.1752 0.1816
Brugia malayi Temporarily assigned gene name protein 59 0.0116 0.0319 0.0331
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0143 0.0463 0.6451
Brugia malayi protein kinase C II. 0.0214 0.086 0.0892
Loa Loa (eye worm) hypothetical protein 0.0093 0.0189 0.0196
Onchocerca volvulus 0.0102 0.0236 0.1069
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0126 0.037 0.0354
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0078 0.0107 0.0111
Schistosoma mansoni tyrosine kinase 0.0136 0.0427 0.0416
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0078 0.0108
Loa Loa (eye worm) hypothetical protein 0.0071 0.0068 0.0071
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0027 0.0025
Entamoeba histolytica hypothetical protein 0.0396 0.1866 0.2998
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.099 0.515 0.5339
Loa Loa (eye worm) hypothetical protein 0.0633 0.3178 0.3295
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0078 0.0108
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0153 0.052 0.0528
Trypanosoma cruzi cdc2-related kinase 3 0.0137 0.0433 0.0437
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0126 0.037 0.5125
Brugia malayi Protein kinase domain containing protein 0.0209 0.083 0.0861
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0065 0.0034 0.0037
Trichomonas vaginalis AGC family protein kinase 0.0178 0.0657 0.1044
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.011 0.0285 0.3909
Giardia lamblia Kinase, CMGC CK2 0.0112 0.0296 0.0855
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0078 0.0108
Onchocerca volvulus 0.0079 0.0111 0.0374
Brugia malayi cyclin-dependent kinase 9 0.0095 0.0199 0.0207
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0188 0.0712 0.0697
Echinococcus multilocularis cyclin dependent kinase 0.0137 0.0433 0.0417
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0217 0.0876 0.0861
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0078 0.0108
Echinococcus granulosus cGMP dependent protein kinase 1 0.0148 0.0495 0.0452
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0233 0.0964 0.0949
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0017 0.0006
Giardia lamblia Kinase, CK1 Casein kinase 0.0121 0.0345 0.1003
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0116 0.0319 0.0308
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0159 0.0554 0.0538
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0256 0.1089 0.1074
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0027 0.0025
Brugia malayi Protein kinase domain containing protein 0.021 0.0836 0.0866
Echinococcus multilocularis mitogen activated protein kinase 0.0095 0.0201 0.0185
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.039 0.1833 0.182
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0234 0.036
Schistosoma mansoni tyrosine kinase 0.038 0.1778 0.1768
Loa Loa (eye worm) animal heme peroxidase 0.0071 0.0068 0.0071
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0095 0.0198 0.1624
Echinococcus multilocularis myosin iiia 0.0096 0.0207 0.019
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0202 0.079 0.0748
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1179 0.6199 1
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0234 0.036
Schistosoma mansoni nephrin 0.0112 0.0297 0.0286
Brugia malayi Stress-activated protein kinase jnk-1 0.0283 0.1242 0.1288
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0168 0.0606 0.0591
Brugia malayi Protein kinase domain containing protein 0.0127 0.0377 0.039
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0188 0.0712 0.0728
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0126 0.037 0.0327
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1802 0.9646 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0188 0.0712 0.6097
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0113 0.03 0.0256
Echinococcus granulosus protein kinase c iota type 0.0298 0.1325 0.1286
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.052 0.0822
Echinococcus granulosus protein kinase 0.0168 0.0602 0.0559
Schistosoma mansoni tyrosine kinase 0.0575 0.2855 0.2847
Entamoeba histolytica protein kinase domain containing protein 0.0095 0.0199 0.0304
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0228 0.0236
Echinococcus multilocularis casein kinase I alpha 0.0121 0.0345 0.0329
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0235 0.0973 0.1009
Loa Loa (eye worm) hypothetical protein 0.0116 0.0319 0.0331
Loa Loa (eye worm) TK protein kinase 0.0161 0.0566 0.0587
Loa Loa (eye worm) hypothetical protein 0.0092 0.0182 0.0189
Echinococcus granulosus serine:threonine protein kinase 0.0127 0.0377 0.0333
Brugia malayi Variant SH3 domain containing protein 0.0088 0.0164 0.017
Giardia lamblia Kinase, CDC7 0.0102 0.0236 0.0676
Echinococcus granulosus casein kinase I gamma 0.023 0.0948 0.0907
Schistosoma mansoni serine/threonine protein kinase 0.024 0.1 0.099
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.0605 0.0594
Trichomonas vaginalis CAMK family protein kinase 0.029 0.1277 0.2046
Trichomonas vaginalis AGC family protein kinase 0.0278 0.1212 0.1941
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0188 0.0712 0.0702
Echinococcus granulosus c-Jun N-terminal kinases 0.0283 0.1242 0.1203
Onchocerca volvulus 0.0116 0.0319 0.1527
Loa Loa (eye worm) hypothetical protein 0.0127 0.0377 0.039
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0197 0.0765 0.0749
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0188 0.0712 1
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0096 0.0207 0.0316
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0139 0.0445 0.0451
Toxoplasma gondii CMGC kinase, CK2 family 0.0112 0.0296 0.2477
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0096 0.0207 0.0196
Plasmodium vivax calcium-dependent protein kinase, putative 0.0113 0.03 0.4123
Entamoeba histolytica protein kinase domain containing protein 0.0135 0.0424 0.0666
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0246 0.1038 0.3085
Brugia malayi P38 map kinase family protein 2 0.1802 0.9646 1
Trypanosoma brucei protein kinase, putative 0.0104 0.0252 0.025
Onchocerca volvulus 0.0325 0.1475 0.7945
Schistosoma mansoni serine/threonine protein kinase 0.0303 0.1354 0.1344
Giardia lamblia Kinase, CMGC CLK 0.0168 0.0605 0.1782
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0475 0.2305 0.239
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0234 0.0223
Echinococcus granulosus tyrosine protein kinase Fyn 0.0197 0.0765 0.0723
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0375 0.1752 0.948
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.037 0.036
Echinococcus granulosus serine:threonine protein kinase 0.0127 0.0377 0.0333
Onchocerca volvulus Peroxidasin homolog 0.0091 0.0176 0.0736
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0092 0.0186 0.1519
Schistosoma mansoni protein kinase 0.0121 0.0345 0.0334
Schistosoma mansoni serine/threonine kinase 0.0168 0.0606 0.0596
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0078 0.0108
Echinococcus granulosus neuroglian 0.0096 0.0207 0.0162
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0132 0.0404 0.0419
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0077 0.0099 0.0082
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.052 0.0509
Trypanosoma brucei protein kinase, putative 0.0142 0.0461 0.0467
Onchocerca volvulus Dual oxidase homolog 0.0071 0.0068 0.0137
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0096 0.0207 0.0203
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0217 0.0876 0.0835
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0136 0.0427 0.0416
Brugia malayi casein kinase 1, delta 0.0121 0.0345 0.0358
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0253 0.1074 0.1059
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0236 0.0225
Trichomonas vaginalis AGC family protein kinase 0.0278 0.1212 0.1941
Schistosoma mansoni tyrosine kinase 0.0636 0.3195 0.3187
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0126 0.037 0.0373
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0113 0.03 0.03
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0391 0.184 0.2956
Plasmodium falciparum serine/threonine protein kinase KIN 0.0101 0.0234 0.3182
Loa Loa (eye worm) TK protein kinase 0.0364 0.1686 0.1748
Giardia lamblia Kinase, NEK 0.015 0.0504 0.1479
Giardia lamblia Kinase, AGC PKA 0.0143 0.0463 0.1358
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0107 0.0096
Brugia malayi Protein kinase domain containing protein 0.0093 0.0188 0.0195
Schistosoma mansoni serine/threonine protein kinase 0.0137 0.0433 0.0422
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0254 0.108 0.1065
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0188 0.0712 0.0738
Echinococcus multilocularis PAK box P21 Rho binding 0.0075 0.009 0.0073
Brugia malayi Egg laying defective protein 4 0.0148 0.0495 0.0513
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0095 0.0201 0.0198
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0234 0.036
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0065 0.0034 0.0035
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0101 0.0234 0.0232
Entamoeba histolytica casein kinase, putative 0.0121 0.0345 0.054
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1179 0.6199 1
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0135 0.0424 0.0428
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0347 0.1595 0.1654
Trypanosoma cruzi casein kinase, putative 0.0121 0.0345 0.0347
Brugia malayi putative serine/threonine kinase SADA gamma 0.0101 0.0234 0.0243
Loa Loa (eye worm) hypothetical protein 0.0093 0.0189 0.0196
Loa Loa (eye worm) hypothetical protein 0.0299 0.1327 0.1375
Trypanosoma cruzi p21-activated kinase 3, putative 0.0065 0.0034 0.0024
Echinococcus multilocularis tyrosine kinase 0.01 0.0228 0.0212
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0148 0.0495 0.4207
Leishmania major casein kinase, putative 0.0121 0.0345 0.0347
Echinococcus granulosus nervana 2 0.01 0.0229 0.0185
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0078 0.0108
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0188 0.0712 0.1133
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1866 1 1
Brugia malayi Protein kinase domain containing protein 0.0197 0.0765 0.0793
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0143 0.0463 0.0447
Echinococcus multilocularis cyclin dependent kinase 7 0.0132 0.0404 0.0388
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0088 0.0164 0.017
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.029 0.1277 0.1263
Plasmodium vivax casein kinase 1, putative 0.0121 0.0345 0.4766
Trichomonas vaginalis AGC family protein kinase 0.016 0.0558 0.0883
Echinococcus granulosus tyrosine protein kinase Lyn 0.0239 0.0999 0.0958
Echinococcus granulosus cyclin dependent kinase 1 0.0137 0.0433 0.0389

Activities

Activity type Activity value Assay description Source Reference
AUC (ADMET) = 316 uM Area under curve plasma concentration of compound in rat when administered perorally at 10 mg/kg dose ChEMBL. 15324899
IC50 (binding) = 0.94 uM In vitro inhibitory concentration against Prostaglandin G/H synthase 2 enzyme activity ChEMBL. 15324899
IC50 (binding) = 0.94 uM In vitro inhibitory concentration against Prostaglandin G/H synthase 2 enzyme activity ChEMBL. 15324899
IC50 (binding) = 1.27 uM Inhibitory concentration against human whole blood Prostaglandin G/H synthase 2 enzyme activity was determined ChEMBL. 15324899
IC50 (binding) = 1.27 uM Inhibitory concentration against human whole blood Prostaglandin G/H synthase 2 enzyme activity was determined ChEMBL. 15324899
IC50 (binding) > 60 uM Inhibitory concentration against human whole blood Prostaglandin G/H synthase 1 enzyme activity ChEMBL. 15324899
IC50 (binding) > 60 uM Inhibitory concentration against human whole blood Prostaglandin G/H synthase 1 enzyme activity ChEMBL. 15324899
Inhibition (functional) = 92 % Percent inhibition of carrageenan induced inflammation in rat air pouch model at 1 mg/kg dose ChEMBL. 15324899
Inhibition (functional) = 92 % Percent inhibition of carrageenan induced inflammation in rat air pouch model at 1 mg/kg dose ChEMBL. 15324899
T1/2 (ADMET) = 6.3 hr Plasma half life of compound was determined in rat ChEMBL. 15324899

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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