TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 444.481 | Formula: C22H28N4O6
H donors: 4 H acceptors: 5 LogP: -0.1 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C1C[C@@H](C(O1)O)NC(=O)[C@@H]1CNC[C@H]2N1C(=O)[C@H](CCCC2)NC(=O)c1ccccc1
InChi: 1S/C22H28N4O6/c27-18-10-16(22(31)32-18)25-20(29)17-12-23-11-14-8-4-5-9-15(21(30)26(14)17)24-19(28)13-6-2-1-3-7-13/h1-3,6-7,14-17,22-23,31H,4-5,8-12H2,(H,24,28)(H,25,29)/t14-,15-,16-,17-,22?/m0/s1
InChiKey: DGOJTUAQSDYETG-VBASKTGHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	caspase 1, apoptosis-related cysteine peptidase	Starlite/ChEMBL	References
Homo sapiens	caspase 3, apoptosis-related cysteine peptidase	Starlite/ChEMBL	References
Homo sapiens	caspase 8, apoptosis-related cysteine peptidase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	caspase-3 (C14 family)	Get druggable targets OG5_130238	All targets in OG5_130238
Schistosoma mansoni	caspase-7 (C14 family)	Get druggable targets OG5_130238	All targets in OG5_130238
Schistosoma japonicum	ko:K02187 caspase 3, apoptosis-related cysteine protease, putative	Get druggable targets OG5_130238	All targets in OG5_130238
Echinococcus granulosus	caspase	Get druggable targets OG5_130238	All targets in OG5_130238
Schistosoma japonicum	ko:K04397 caspase 7, apoptosis-related cysteine protease, putative	Get druggable targets OG5_130238	All targets in OG5_130238
Echinococcus granulosus	caspase 3	Get druggable targets OG5_130238	All targets in OG5_130238
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	Get druggable targets OG5_130238	All targets in OG5_130238
Echinococcus multilocularis	caspase 3	Get druggable targets OG5_130238	All targets in OG5_130238
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	Get druggable targets OG5_130238	All targets in OG5_130238
Echinococcus multilocularis	caspase	Get druggable targets OG5_130238	All targets in OG5_130238

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Cell death protein 3 precursor	caspase 3, apoptosis-related cysteine peptidase	277 aa	253 aa	38.7 %
Echinococcus granulosus	caspase 8	caspase 1, apoptosis-related cysteine peptidase	383 aa	312 aa	26.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0075	0.0017	0.0013
Brugia malayi	probable protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	NEK protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK-like	0.0058	0.0004	0.5
Loa Loa (eye worm)	BUB protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	CASK	0.0058	0.0004	0.0004
Mycobacterium ulcerans	anchored-membrane serine/threonine-protein kinase PknF	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK-frag	0.0058	0.0004	0.5
Loa Loa (eye worm)	TKL/IRAK protein kinase	0.0058	0.0004	0.0004
Brugia malayi	cell division control protein 2 homolog	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Long-flagella protein, kinase, CMGC RCK	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, Wee	0.0058	0.0004	0.5
Brugia malayi	hypothetical protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1/TTBKL protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Phospholipase A2 family protein	0.1295	0.092	0.0923
Brugia malayi	Ribonuclease 2-5A family protein	0.0058	0.0004	0.0004
Chlamydia trachomatis	serine/threonine protein kinase	0.0058	0.0004	0.5
Loa Loa (eye worm)	STE/STE20/PAKB protein kinase	0.0058	0.0004	0.0004
Brugia malayi	serine/threonine-protein kinase 6	0.0058	0.0004	0.0004
Schistosoma mansoni	hypothetical protein	0.0088	0.0027	0.0022
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	NRBP protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, CMGC CDK	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.5255	0.3849	0.3864
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0075	0.0017	1
Giardia lamblia	Kinase, STE STE20	0.0058	0.0004	0.5
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, CMGC CMGC-GL1	0.0058	0.0004	0.5
Loa Loa (eye worm)	WEE protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, VPS15	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	P38 map kinase family protein 2	1.0423	0.7672	0.7701
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	CMGC/CDK protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Serine/threonine-protein kinase ZK507.1	0.0058	0.0004	0.0004
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK-frag	0.0058	0.0004	0.5
Brugia malayi	hypothetical protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	TKL/MLK/MLK protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1/TTBKL protein kinase	0.0058	0.0004	0.0004
Leishmania major	protein kinase, putative	0.0063	0.0008	0.0005
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.5694	0.4174	0.419
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Trypanosoma cruzi	metacaspase, putative	0.0075	0.0017	0.0017
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	hypothetical protein	0.5255	0.3849	0.3864
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	MGC81364 protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1 protein kinase	0.0058	0.0004	0.0004
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0075	0.0017	1
Loa Loa (eye worm)	CAMK/DAPK/DAPK protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0058	0.0004	0.0004
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0063	0.0008	0.0004
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0058	0.0004	0.5
Loa Loa (eye worm)	CAMK protein kinase	0.006	0.0006	0.0006
Loa Loa (eye worm)	CMGC/DYRK/PRP4 protein kinase	0.0058	0.0004	0.0004
Trypanosoma brucei	metacaspase 5, putative	0.0075	0.0017	0.0017
Giardia lamblia	Hypothetical protein	0.0058	0.0004	0.5
Brugia malayi	Ser/Thr kinase.	0.0058	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CAMK/CAMKL/LKB protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK-like	0.0058	0.0004	0.5
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0163	0.0082	0.0078
Loa Loa (eye worm)	CAMK/CASK protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, Nek-like	0.0058	0.0004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0058	0.0004	0.0004
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	1.0423	0.7672	1
Brugia malayi	Neuronal symmetry protein 1	0.0058	0.0004	0.0004
Brugia malayi	bone morphogenetic protein type 1 receptor	1.3518	0.9961	1
Giardia lamblia	Kinase	0.0058	0.0004	0.5
Brugia malayi	Casein kinase II, alpha chain	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	STE/STE20/STLK protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	protein kinase C3,putative	0.0058	0.0004	0.0004
Loa Loa (eye worm)	STE/STE7/MEK3 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	TKL/LISK/TESK protein kinase	0.0058	0.0004	0.0004
Echinococcus multilocularis	caspase 3	0.0088	0.0027	0.0022
Trypanosoma brucei	metacaspase	0.0075	0.0017	0.0017
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	serine/threonine-protein kinase plk-2	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Echinococcus granulosus	mitogen activated protein kinase 11	1.0423	0.7672	0.7671
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	NAK/MPSK protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase	0.0058	0.0004	0.5
Brugia malayi	Serine/threonine-protein kinase K06H7.1	0.0058	0.0004	0.0004
Brugia malayi	glycogen synthase kinase 3 alpha	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, PLK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, CMGC CDK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, STE STE20	0.0058	0.0004	0.5
Brugia malayi	casein kinase 1, delta	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, CMGC DYRK	0.0058	0.0004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0004	0.0004
Trichomonas vaginalis	conserved hypothetical protein	0.0075	0.0017	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	1.3518	0.9961	1
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	STE/STE11/ASK protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK-frag	0.0058	0.0004	0.5
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, AGC AKT	0.0058	0.0004	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0063	0.0008	0.0005
Brugia malayi	Serine/threonine-protein kinase C05D10.2 in chromosome III	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK-like	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Trypanosoma cruzi	metacaspase, putative	0.0075	0.0017	0.0017
Giardia lamblia	Kinase, AGC PKA	0.0058	0.0004	0.5
Brugia malayi	Protein kinase sperm-specific MAP kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, CMGC DYRK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	ULK protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.006	0.0006	0.0006
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	TM2 domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, CMGC CDK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	MAP kinase sur-1	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK-frag	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	PEK/HRI protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0058	0.0004	0.0004
Giardia lamblia	Kinase	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK-frag	0.0058	0.0004	0.5
Trypanosoma cruzi	metacaspase, putative	0.0075	0.0017	0.0017
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0004	0.0004
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0006	0.0002
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, CMGC DYRK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	CK1 protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CAMK/CAMKL/AMPK protein kinase	0.0058	0.0004	0.0004
Schistosoma mansoni	titin	0.006	0.0006	0.0002
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, STE Dicty2	0.0058	0.0004	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0075	0.0017	1
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0163	0.0082	0.0078
Plasmodium falciparum	metacaspase 1	0.0075	0.0017	1
Brugia malayi	Protein kinase domain containing protein	0.5694	0.4174	0.419
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0058	0.0004	0.0004
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0075	0.0017	1
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0075	0.0017	1
Loa Loa (eye worm)	AGC/DMPK/ROCK protein kinase	0.0058	0.0004	0.0004
Echinococcus multilocularis	mitogen activated protein kinase 14	1.0423	0.7672	0.7671
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0063	0.0008	0.0008
Echinococcus granulosus	caspase 2	0.0163	0.0082	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0004	0.0004
Brugia malayi	cell division control protein 2 homolog	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Echinococcus multilocularis	titin	0.006	0.0006	0.0002
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	AGC/MAST/MAST protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Cell death protein 3 precursor	0.0163	0.0082	0.0082
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0058	0.0004	0.0004
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0075	0.0017	1
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Echinococcus multilocularis	mitogen activated protein kinase 11	1.0423	0.7672	0.7671
Echinococcus multilocularis	mitogen activated protein kinase 14	1.0423	0.7672	0.7671
Trypanosoma brucei	metacaspase MCA2	0.0075	0.0017	0.0017
Plasmodium vivax	metacaspase 1, putative	0.0075	0.0017	1
Giardia lamblia	Kinase, STE Dicty2	0.0058	0.0004	0.5
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1/TTBK protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	ULK/ULK protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0075	0.0017	0.0017
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Schistosoma mansoni	caspase-7 (C14 family)	0.0163	0.0082	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0075	0.0017	1
Giardia lamblia	Kinase, CMGC CDK	0.0058	0.0004	0.5
Brugia malayi	intracellular kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1/VRK protein kinase	0.0058	0.0004	0.0004
Echinococcus granulosus	titin	0.006	0.0006	0.0002
Loa Loa (eye worm)	CK1/TTBKL protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK-frag	0.0058	0.0004	0.5
Brugia malayi	cell division protein kinase 10	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1 protein kinase	0.0058	0.0004	0.0004
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Onchocerca volvulus	Phospholipase A2 homolog	0.1295	0.092	1
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	1.0423	0.7672	0.7701
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK-frag	0.0058	0.0004	0.5
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CMGC/CDK/CRK7 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Aurora kinase	0.0058	0.0004	0.5
Giardia lamblia	Kinase, CAMKK	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	activin receptor:ISOTYPE=IIA.	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	STE/STE11/MEKK2 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	WNK protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	STE/STE7/MEK4 protein kinase	0.0058	0.0004	0.0004
Onchocerca volvulus		0.006	0.0006	0.0018
Giardia lamblia	Kinase, STE STE11	0.0058	0.0004	0.5
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	TKL/STKR/TYPE2 protein kinase	0.5313	0.3892	0.3907
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Onchocerca volvulus	Tyrosine kinase homolog	0.0135	0.0062	0.0625
Loa Loa (eye worm)	STE/STE20/SLK protein kinase	0.0058	0.0004	0.0004
Brugia malayi	phosphoinositide-dependent protein kinase I	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) (STPK E)	0.0058	0.0004	0.5
Echinococcus granulosus	TGF-beta receptor type-1	1.3571	1	1
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CMGC/SRPK protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, CMGC RCK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	p70 ribosomal S6 kinase beta	0.0058	0.0004	0.0004
Trichomonas vaginalis	conserved hypothetical protein	0.0075	0.0017	1
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0058	0.0004	0.0004
Trypanosoma brucei	metacaspase MCA3	0.0075	0.0017	0.0017
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	putative serine/threonine kinase SADA gamma	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	TTK protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0058	0.0004	0.0004
Mycobacterium ulcerans	serine/threonine-protein kinase transcriptional regulatory protein PknK_3	0.0058	0.0004	0.5
Mycobacterium tuberculosis	Serine/threonine-protein kinase PknG (protein kinase G) (STPK G)	0.0058	0.0004	0.5
Echinococcus multilocularis	caspase 2	0.0163	0.0082	0.0078
Loa Loa (eye worm)	hypothetical protein	0.1295	0.092	0.0923
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	TKL/MLK/LZK protein kinase	0.0058	0.0004	0.0004
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0063	0.0008	0.3095
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0017	0.0017
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Echinococcus multilocularis	caspase 8	0.0075	0.0017	0.0013
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, CAMK CAMKL	0.0058	0.0004	0.5
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1/TTBKL protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, CAMK CAMKL	0.0058	0.0004	0.5
Loa Loa (eye worm)	STE/STE20/YSK protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK-GL-like	0.0058	0.0004	0.5
Brugia malayi	serine/threonine-protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	serine/threonine-protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	hypothetical protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, CMGC CDK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	serine/threonine protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CAMK/CAMKL/NIM1 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Mycobacterium ulcerans	transmembrane serine/threonine-protein kinase PknQ	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CMGC/CDK/CDK10 protein kinase	0.0058	0.0004	0.0004
Plasmodium falciparum	protein kinase, putative	0.0063	0.0008	0.3095
Mycobacterium tuberculosis	Serine/threonine-protein kinase transcriptional regulatory protein PknK (protein kinase K) (STPK K)	0.0058	0.0004	0.5
Echinococcus multilocularis	twitchin	0.006	0.0006	0.0002
Chlamydia trachomatis	serine/threonine protein kinase	0.0058	0.0004	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0144	0.0068	0.0069
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	1.0423	0.7672	1
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	NEK/NEK6 protein kinase	0.0058	0.0004	0.0004
Trypanosoma brucei	protein kinase, putative	0.0063	0.0008	0.0005
Echinococcus granulosus	activin receptor type	0.6583	0.4831	0.4829
Giardia lamblia	Kinase, ULK	0.0058	0.0004	0.5
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	1.0423	0.7672	1
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	CAMK/TRBL protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, CAMK CAMKL	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	CMGC/CDK/CDK7 protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Serine/threonine-protein kinase K06H7.1	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, CMGC CDK	0.0058	0.0004	0.5
Loa Loa (eye worm)	TLK protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, Nek-like	0.0058	0.0004	0.5
Schistosoma mansoni	protein kinase	1.3571	1	1
Giardia lamblia	Kinase, NEK-frag	0.0058	0.0004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0027	0.0027
Loa Loa (eye worm)	plk/plk-unclassified protein kinase	0.0058	0.0004	0.0004
Brugia malayi	serine/threonine protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	AGC/YANK protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0075	0.0017	1
Loa Loa (eye worm)	CMGC/CDK protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, CMGC RCK	0.0058	0.0004	0.5
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, STE STE20	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	STE/STE20/PAKA protein kinase	0.0058	0.0004	0.0004
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0075	0.0017	1
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0058	0.0004	0.0004
Brugia malayi	serine/threonine kinase 12	0.0058	0.0004	0.0004
Giardia lamblia	Kinase	0.0058	0.0004	0.5
Loa Loa (eye worm)	CAMK/TSSK protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Serine/threonine-protein kinase SULU	0.0058	0.0004	0.0004
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0144	0.0068	0.0069
Mycobacterium ulcerans	serine/threonine-protein kinase B PknB	0.0058	0.0004	0.5
Brugia malayi	KIAA0303	0.0058	0.0004	0.0004
Echinococcus granulosus	caspase 3	0.0088	0.0027	0.0022
Loa Loa (eye worm)	IKK protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Trypanosoma cruzi	metacaspase, putative	0.0075	0.0017	0.0017
Brugia malayi	Dual specificity mitogen-activated protein kinase kinase 6	0.0058	0.0004	0.0004
Brugia malayi	ribosomal protein S6 kinase alpha 3	0.0058	0.0004	0.0004
Loa Loa (eye worm)	STE/STE20/PAKA protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase	0.0058	0.0004	0.5
Mycobacterium leprae	Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B)	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	protein C17H12.11	0.5255	0.3849	0.3864
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	STE/STE20/KHS protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, AGC MAST	0.0058	0.0004	0.5
Giardia lamblia	Kinase	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0075	0.0017	1
Giardia lamblia	Kinase, NEK-frag	0.0058	0.0004	0.5
Loa Loa (eye worm)	CK1 protein kinase	0.0058	0.0004	0.0004
Onchocerca volvulus	Cell death protein 3 homolog	0.0163	0.0082	0.0849
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CAMK/CAMKL/SNRK protein kinase	0.0058	0.0004	0.0004
Chlamydia trachomatis	serine/threonine-protein kinase	0.0058	0.0004	0.5
Loa Loa (eye worm)	STE/STE20/FRAY protein kinase	0.0058	0.0004	0.0004
Brugia malayi	serine/threonine protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	haspin protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, CMGC DYRK	0.0058	0.0004	0.5
Loa Loa (eye worm)	CAMK/TSSK protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, CAMK CAMKL	0.0058	0.0004	0.5
Schistosoma mansoni	protein kinase	0.0063	0.0008	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Dual specificity mitogen-activated protein kinase kinase 7. -TRUNCATED-	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, CMGC CDKL	0.0058	0.0004	0.5
Brugia malayi	hypothetical protein	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK-frag	0.0058	0.0004	0.5
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0058	0.0004	0.0004
Brugia malayi	Dual specificity mitogen-activated protein kinase kinase 7. -TRUNCATED-	0.0058	0.0004	0.0004
Echinococcus multilocularis	activin receptor type	0.6583	0.4831	0.4829
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	CAMKK/META protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CAMK/CAMKL/BRSK protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, CMGC CK2	0.0058	0.0004	0.5
Giardia lamblia	Kinase, CMGC GSK	0.0058	0.0004	0.5
Mycobacterium tuberculosis	Anchored-membrane serine/threonine-protein kinase PknF (protein kinase F) (STPK F)	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK-like	0.0058	0.0004	0.5
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	NEK/NEK8 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, CMGC MAPK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK-frag	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	STE/STE7/MEK1 protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	VPS15 protein kinase	0.0058	0.0004	0.0004
Brugia malayi	oxidative-stress responsive 1	0.0058	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Echinococcus granulosus	mitogen activated protein kinase 14	1.0423	0.7672	0.7671
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	SCY1 protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	SCY1 protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Pctaire class cell cycle kinase protein 1	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CMGC/CDK/CDK9 protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	p21/Cdc42/Rac1-activated kinase	0.0058	0.0004	0.0004
Onchocerca volvulus	Phospholipase A2 homolog	0.1295	0.092	1
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, CDC7	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Schistosoma mansoni	protein kinase	0.0063	0.0008	0.0004
Giardia lamblia	Kinase, NEK-frag	0.0058	0.0004	0.5
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CMGC/MAPK/NMO protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK-like	0.0058	0.0004	0.5
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1/TTBKL protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase	0.0058	0.0004	0.5
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0063	0.0008	0.0004
Giardia lamblia	Kinase, CMGC GSK	0.0058	0.0004	0.5
Mycobacterium ulcerans	serine/threonine-protein kinase a PknA	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	CAMK/CAMKL/MARK protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, STE STE20	0.0058	0.0004	0.5
Loa Loa (eye worm)	TBCK protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	AUR protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	NAK/BIKE protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	CAMK/CAMKL/MELK protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, ULK	0.0058	0.0004	0.5
Mycobacterium ulcerans	serine/threonine-protein kinase PknG	0.0058	0.0004	0.5
Loa Loa (eye worm)	IRE protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK-frag	0.0058	0.0004	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.006	0.0006	0.0006
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0004	0.0004
Brugia malayi	cyclin-dependent kinase 9	0.0058	0.0004	0.0004
Brugia malayi	map kinase activated protein kinase protein 2	0.0058	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.1295	0.092	0.0923
Loa Loa (eye worm)	camk/mapkapk/mnk protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK-frag	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	cell division control protein 2 homolog	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, TTK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Stress-activated protein kinase jnk-1	0.0058	0.0004	0.0004
Mycobacterium ulcerans	serine/threonine-protein kinase PknF_2	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK-frag	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	AGC protein kinase	0.0058	0.0004	0.0004
Mycobacterium leprae	PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE L PKNL (PROTEIN KINASE L) (STPK L)	0.0058	0.0004	0.5
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	serine/threonine protein kinase	0.0058	0.0004	0.0004
Brugia malayi	FMRFamide related peptide family protein	0.0058	0.0004	0.0004
Brugia malayi	Serine/threonine-protein kinase C07A9.3	0.0058	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1/TTBK protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CAMK/CAMKL/NUAK protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1 protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CMGC/MAPK protein kinase	0.0058	0.0004	0.0004
Mycobacterium tuberculosis	Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A)	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CMGC/DYRK/HIPK protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Homeodomain interacting protein kinase protein 1	0.0058	0.0004	0.0004
Mycobacterium tuberculosis	Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B)	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0088	0.0027	0.0022
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Mycobacterium ulcerans	serine/threonine-protein kinase transcriptional regulatory protein PknK_2	0.0058	0.0004	0.5
Loa Loa (eye worm)	NAK/GAK protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	STE/STE7/MEK4 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	STE/STE11/MEKK4 protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	serine/threonine protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1/CK1/CK1-D protein kinase	0.0058	0.0004	0.0004
Trypanosoma cruzi	metacaspase 5, putative	0.0075	0.0017	0.0017
Loa Loa (eye worm)	STE/STE7 protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	STE/STE7/MEK7 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Echinococcus granulosus	titin	0.006	0.0006	0.0002
Brugia malayi	Serine/threonine-protein kinase F42G10.2	0.0058	0.0004	0.0004
Echinococcus multilocularis	caspase	0.0163	0.0082	0.0078
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0063	0.0008	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0075	0.0017	1
Onchocerca volvulus		0.0088	0.0027	0.0244
Echinococcus granulosus	caspase	0.0163	0.0082	0.0078
Loa Loa (eye worm)	cmgc/cdk/pitslre protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase	0.0058	0.0004	0.5
Brugia malayi	casein kinase I	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CAMK/PHK protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1/DUAL protein kinase	0.0058	0.0004	0.0004
Echinococcus multilocularis	serine:threonine protein kinase receptor R3	0.6578	0.4828	0.4825
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	Variant SH3 domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	CMGC/CK2 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	serine/threonine-protein kinase PAK 7	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, CAMK unique	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Entamoeba histolytica	protein kinase domain containing protein	0.0063	0.0008	1
Giardia lamblia	Kinase, CAMK CAMKL	0.0058	0.0004	0.5
Giardia lamblia	Kinase	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0075	0.0017	1
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CMGC/CDK/CDK4 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CAMK/CAMKL/PASK protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NAK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Serine/threonine-protein kinase Nek7	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1/TTBKL protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, STE STE20	0.0058	0.0004	0.5
Schistosoma mansoni	protein kinase	0.6254	0.4588	0.4586
Loa Loa (eye worm)	serine/threonine protein kinase	0.0058	0.0004	0.0004
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0075	0.0017	1
Brugia malayi	Cell division protein kinase 2	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	hypothetical protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Dual-specificity tyrosine-phosphorylation regulated kinase 2	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	cyclin-dependent kinase 7 homolog	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CMGC/CDK protein kinase	0.0058	0.0004	0.0004
Brugia malayi	glycogen synthase kinase	0.0058	0.0004	0.0004
Brugia malayi	protein kinase C II.	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK-frag	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CMGC/RCK/MAK protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1/TTBK protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CMGC/CDK/CDK8 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK-frag	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Trypanosoma cruzi	metacaspase 5, putative	0.0075	0.0017	0.0017
Schistosoma mansoni	caspase-7 (C14 family)	0.0163	0.0082	0.0078
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	PEK/PEK protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CDC7 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, Uni1	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Schistosoma mansoni	protein kinase	0.0063	0.0008	0.0004
Loa Loa (eye worm)	STE/STE20/MSN protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	Serine/threonine-protein kinase K06H7.1	0.0058	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	Cam kinase protein 1	0.0058	0.0004	0.0004
Loa Loa (eye worm)	STE/STE20/MST protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, CMGC CLK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, STE STE20	0.0058	0.0004	0.5
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, Wnk	0.0058	0.0004	0.5
Brugia malayi	C1-like domain containing protein	0.0058	0.0004	0.0004
Mycobacterium leprae	Probable transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A)	0.0058	0.0004	0.5
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0058	0.0004	0.0004
Loa Loa (eye worm)	camk/dcamkl protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0004	0.0004
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0063	0.0008	0.0005
Loa Loa (eye worm)	CMGC/MAPK protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase I PknI (protein kinase I) (STPK I) (phosphorylase B kinase kinase) (hydro	0.0058	0.0004	0.5
Brugia malayi	Egg laying defective protein 4	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase	0.0058	0.0004	0.5
Giardia lamblia	Kinase, CMGC SRPK	0.0058	0.0004	0.5
Brugia malayi	PRKD2 protein	0.0058	0.0004	0.0004
Onchocerca volvulus		0.0127	0.0056	0.0564
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	protein unc-22	0.006	0.0006	0.0006
Loa Loa (eye worm)	serine/threonine protein kinase	0.0058	0.0004	0.0004
Brugia malayi	HLS7-interacting protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0058	0.0004	0.0004
Brugia malayi	cell division control protein 2 homolog	0.0058	0.0004	0.0004
Brugia malayi	RWD domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	AUR protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, AGC PKA	0.0058	0.0004	0.5
Giardia lamblia	Kinase, PEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase	0.0058	0.0004	0.5
Echinococcus granulosus	twitchin	0.0068	0.0012	0.0008
Loa Loa (eye worm)	CAMK/DAPK/DAPK protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CMGC/DYRK/DYRK2 protein kinase	0.0058	0.0004	0.0004
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Echinococcus multilocularis	mitogen activated protein kinase 11	1.0423	0.7672	0.7671
Leishmania major	metacaspase, putative	0.0075	0.0017	0.0017
Brugia malayi	Doublecortin family protein	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	Hr1 repeat family protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Trypanosoma brucei	Metacaspase-4	0.0075	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0163	0.0082	0.0082
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Echinococcus multilocularis	TGF beta receptor type 1	1.3571	1	1
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	Serine/threonine-protein kinase SULU	0.0058	0.0004	0.0004
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	hypothetical protein	0.0088	0.0027	0.0027
Schistosoma mansoni	caspase-3 (C14 family)	0.0163	0.0082	0.0078
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0058	0.0004	0.0004
Trichomonas vaginalis	conserved hypothetical protein	0.0075	0.0017	1
Loa Loa (eye worm)	CAMK/TSSK protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase c protein 2	0.0058	0.0004	0.0004
Loa Loa (eye worm)	AUR protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, CMGC CMGC-GL1	0.0058	0.0004	0.5
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase H PknH (protein kinase H) (STPK H)	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK-frag	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	Germinal center kinase family protein 1	0.0058	0.0004	0.0004
Brugia malayi	Dual specificity mitogen-activated protein kinase kinase mek-2	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0075	0.0017	1
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NAK	0.0058	0.0004	0.5
Brugia malayi	STE20-like kinase MST	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0075	0.0017	1
Giardia lamblia	Kinase	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, CAMK CAMK1	0.0058	0.0004	0.5
Loa Loa (eye worm)	CAMK protein kinase	0.0058	0.0004	0.0004
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0063	0.0008	0.0005
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	CAMK/PSK protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK-frag	0.0058	0.0004	0.5
Echinococcus granulosus	apoptotic protease activating factor 1	0.0088	0.0027	0.0022
Giardia lamblia	Kinase, CK1 Casein kinase	0.0058	0.0004	0.5
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0075	0.0017	1
Giardia lamblia	Kinase	0.0058	0.0004	0.5
Loa Loa (eye worm)	STE/STE7/MEK7 protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Mitogen-activated protein kinase	0.0058	0.0004	0.0004
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0006	0.0002
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0058	0.0004	0.0004
Brugia malayi	EST embl\|AI107989\|AI107989 comes from the 3' UTR, putative	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0058	0.0004	0.0004
Brugia malayi	serine/threonine protein kinase 6	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Echinococcus granulosus	caspase 8	0.0075	0.0017	0.0013
Giardia lamblia	Kinase, CMGC MAPK	0.0058	0.0004	0.5
Mycobacterium ulcerans	membrane-anchored serine/threonine-protein kinase	0.0058	0.0004	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	serine/threonine protein kinase	0.0058	0.0004	0.0004
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	1.0423	0.7672	1
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK	0.0058	0.0004	0.5
Brugia malayi	Calcium/calmodulin-dependent serine/threonine-protein kinase	0.0058	0.0004	0.0004
Giardia lamblia	Kinase, AGC NDR	0.0058	0.0004	0.5
Giardia lamblia	Kinase, NEK-frag	0.0058	0.0004	0.5
Plasmodium falciparum	metacaspase-like protein	0.0075	0.0017	1
Loa Loa (eye worm)	STE/STE20/TAO protein kinase	0.0058	0.0004	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 10 nM	Inhibitory activity against Caspase 1	ChEMBL.	16216507
IC50 (binding)	= 10 nM	Inhibitory activity against Caspase 1	ChEMBL.	16216507
IC50 (functional)	= 245 nM	Inhibitory activity in THP1 whole cell assay measuring IL-1beta production	ChEMBL.	16216507
IC50 (functional)	= 245 nM	Inhibitory activity in THP1 whole cell assay measuring IL-1beta production	ChEMBL.	16216507
IC50 (binding)	= 384 nM	Inhibitory activity against Caspase 8	ChEMBL.	16216507
IC50 (binding)	= 384 nM	Inhibitory activity against Caspase 8	ChEMBL.	16216507
IC50 (binding)	> 10000 nM	Inhibitory activity against Caspase 3	ChEMBL.	16216507
IC50 (binding)	> 10000 nM	Inhibitory activity against Caspase 3	ChEMBL.	16216507

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	16216507

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL198743

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 345983