Detailed information for compound 374916

Basic information

Technical information
  • TDR Targets ID: 374916
  • Name: (1R,2S,5S)-N-(4-amino-1-cyclopropyl-3,4-dioxo butan-2-yl)-3-[(2S)-2-[[tert-butyl(methyl)car bamoyl]amino]-3,3-dimethylbutanoyl]-6,6-dimet hyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
  • MW: 519.677 | Formula: C27H45N5O5
  • H donors: 3 H acceptors: 5 LogP: 2.79 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C([C@H]1N(C[C@H]2[C@@H]1C2(C)C)C(=O)[C@H](C(C)(C)C)NC(=O)N(C(C)(C)C)C)NC(C(=O)C(=O)N)CC1CC1
  • InChi: 1S/C27H45N5O5/c1-25(2,3)20(30-24(37)31(9)26(4,5)6)23(36)32-13-15-17(27(15,7)8)18(32)22(35)29-16(12-14-10-11-14)19(33)21(28)34/h14-18,20H,10-13H2,1-9H3,(H2,28,34)(H,29,35)(H,30,37)/t15-,16?,17-,18-,20+/m0/s1
  • InChiKey: PFUMEOBJFIZGIN-DOVBMPENSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (1R,2S,5S)-N-[3-amino-1-(cyclopropylmethyl)-2,3-dioxo-propyl]-3-[(2S)-2-[[tert-butyl(methyl)carbamoyl]amino]-3,3-dimethyl-butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
  • (1R,2S,5S)-N-[3-amino-1-(cyclopropylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[tert-butyl(methyl)amino]-oxomethyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
  • (1R,2S,5S)-N-(4-azanyl-1-cyclopropyl-3,4-dioxo-butan-2-yl)-3-[(2S)-2-[[tert-butyl(methyl)carbamoyl]amino]-3,3-dimethyl-butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
  • (1R,2S,5S)-N-[3-amino-1-(cyclopropylmethyl)-2,3-diketo-propyl]-3-[(2S)-2-[[tert-butyl(methyl)carbamoyl]amino]-3,3-dimethyl-butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
  • (1R,2S,5S)-N-(4-amino-1-cyclopropyl-3,4-dioxobutan-2-yl)-3-[(2S)-2-[(tert-butyl-methylcarbamoyl)amino]-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
  • (1R,2S,5S)-N-[3-amino-1-(cyclopropylmethyl)-2,3-dioxo-propyl]-3-[(2S)-2-[(tert-butyl-methyl-carbamoyl)amino]-3,3-dimethyl-butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
  • (1R,2S,5S)-N-[3-amino-1-(cyclopropylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[(tert-butyl-methylamino)-oxomethyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
  • (1R,2S,5S)-N-[3-amino-1-(cyclopropylmethyl)-2,3-diketo-propyl]-3-[(2S)-2-[(tert-butyl-methyl-carbamoyl)amino]-3,3-dimethyl-butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
  • (1R,2S,5S)-N-(4-amino-1-cyclopropyl-3,4-dioxo-butan-2-yl)-3-[(2S)-2-[(tert-butyl-methyl-carbamoyl)amino]-3,3-dimethyl-butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Hepatitis C virus Hepatitis C virus NS3 protease/helicase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus granulosus eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma mansoni DEAD box ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium vivax RNA helicase-1, putative Get druggable targets OG5_126984 All targets in OG5_126984
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126984 All targets in OG5_126984
Cryptosporidium hominis eukaryotic initiation factor 4A (eIF4A) (eIF-4A) Get druggable targets OG5_126984 All targets in OG5_126984
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma brucei Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania mexicana Get druggable targets OG5_126984 All targets in OG5_126984
Babesia bovis eukaryotic translation initiation factor 4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Neospora caninum DEAD-box ATP-dependent RNA helicase 34 (EC 3.6.1.-), related Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Candida albicans similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania donovani Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium knowlesi eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania major eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania major eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus granulosus eukaryotic initiation factor 4A III Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma japonicum Eukaryotic initiation factor 4A-II, putative Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium yoelii RNA helicase-1 Get druggable targets OG5_126984 All targets in OG5_126984
Cryptosporidium parvum eukaryotic initiation factor 4A (eIF4A) (eIF-4A) Get druggable targets OG5_126984 All targets in OG5_126984
Candida albicans similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit Get druggable targets OG5_126984 All targets in OG5_126984
Brugia malayi eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma japonicum ATP-dependent RNA helicase eIF4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma mansoni DEAD box ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma japonicum Eukaryotic initiation factor 4A-III, putative Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus multilocularis eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Giardia lamblia Translation initiation factor eIF-4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania infantum eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus multilocularis eukaryotic initiation factor 4A III Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium berghei eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Toxoplasma gondii eukaryotic initiation factor-4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Onchocerca volvulus Eukaryotic initiation factor 4A homolog Get druggable targets OG5_126984 All targets in OG5_126984
Theileria parva RNA helicase-1, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma congolense eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania braziliensis eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania infantum eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Treponema pallidum ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium falciparum eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Entamoeba histolytica DEAD/DEAH box helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Pyruvate kinase, muscle isozyme 0.0038 0.0065 0.0062
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0059 0.0056
Echinococcus granulosus dnaJ subfamily B 0.1731 0.4421 0.4419
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0007 0.0004
Schistosoma mansoni ferritin 0.0016 0.0009 0.0007
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0039 0.0067 0.1204
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0011 0.0009
Entamoeba histolytica hypothetical protein 0.0019 0.0016 0.0521
Onchocerca volvulus 0.0026 0.0034 0.003
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0105 0.0238 0.0235
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0071 0.012
Onchocerca volvulus 0.0105 0.0238 0.0234
Loa Loa (eye worm) hypothetical protein 0.0039 0.0067 0.0065
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0263 0.0644 0.218
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.0108 0.0106
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0016 0.0009 0.0011
Brugia malayi MH2 domain containing protein 0.013 0.0303 0.0301
Echinococcus granulosus pyruvate kinase 0.0038 0.0065 0.0062
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0005 0.0005
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0795 0.2013 0.2011
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0011 0.0015
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.0007 0.0056
Onchocerca volvulus 0.0026 0.0034 0.003
Echinococcus multilocularis Niemann Pick C1 protein 0.016 0.0378 0.0376
Brugia malayi hypothetical protein 0.0026 0.0034 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0035 0.1297
Onchocerca volvulus 0.002 0.0019 0.0015
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0012 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0034 0.0031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0151 0.0149
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0032 0.047
Loa Loa (eye worm) hypothetical protein 0.0029 0.0042 0.0039
Echinococcus granulosus geminin 0.0881 0.2234 0.2232
Schistosoma mansoni hypothetical protein 0.0046 0.0086 0.0084
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0005 0.0033
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0254 0.062 0.2098
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0019 0.0017
Plasmodium vivax acyl-CoA synthetase, putative 0.0039 0.0067 0.1044
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0003 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0038 0.3002
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.002 0.0019 0.0017
Trypanosoma brucei prolyl oligopeptidase, putative 0.0062 0.0127 0.0217
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0223 0.054 0.0538
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0062 0.0127 0.0124
Onchocerca volvulus 0.0055 0.0108 0.0104
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.002 0.0019 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.0108 0.0106
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0046
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0055 0.0108 0.0106
Loa Loa (eye worm) hypothetical protein 0.0055 0.0108 0.0106
Onchocerca volvulus 0.002 0.0019 0.0015
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0007 0.0099
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0003 0.0001
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1225 0.3118 0.3117
Loa Loa (eye worm) hypothetical protein 0.0039 0.0067 0.0065
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0027 0.0024
Loa Loa (eye worm) serotonin transporter b 0.0149 0.0349 0.0347
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.015 0.0148
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0023 0.0021
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0062 0.0127 0.0217
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0007 0.0007
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0004 0.0313
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0055 0.0108 0.0106
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.002 0.0019 0.0017
Loa Loa (eye worm) oxidoreductase 0.0015 0.0007 0.0004
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0025 0.0032 0.003
Schistosoma mansoni tar DNA-binding protein 0.0208 0.0503 0.0501
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0098 0.0095
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0019 0.0017
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0048 0.008
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0011 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0101 0.1594
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0066 0.0111
Leishmania major eukaryotic initiation factor 4a, putative 0.003 0.0043 0.0071
Loa Loa (eye worm) CXXC zinc finger family protein 0.0122 0.028 0.0278
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0007 0.0004
Schistosoma mansoni protein-tyrosine phosphatase n9 0.002 0.0019 0.0017
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0062 0.0127 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0055 0.0108 0.0106
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0071 0.1266
Echinococcus multilocularis high affinity choline transporter 1 0.0083 0.018 0.0178
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0151 0.0149
Schistosoma mansoni sodium/chloride dependent transporter 0.0025 0.0032 0.003
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.002 0.0019 0.0017
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0055 0.0108 0.0106
Leishmania major pyruvate kinase 0.0038 0.0065 0.0109
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0071 0.0068
Mycobacterium tuberculosis Probable reductase 0.0092 0.0204 0.3678
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0031
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0055 0.0108 0.0106
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0263 0.0644 0.1121
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0065 0.5011
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0015 0.0005 0.0108
Loa Loa (eye worm) hypothetical protein 0.0254 0.062 0.0617
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0011 0.0009
Echinococcus granulosus prolyl endopeptidase 0.0062 0.0127 0.0124
Loa Loa (eye worm) beta-lactamase 0.0036 0.0059 0.0056
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0014 0.0003 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0003 0.0001
Loa Loa (eye worm) protein-tyrosine phosphatase 0.002 0.0019 0.0017
Onchocerca volvulus 0.002 0.0019 0.0015
Echinococcus granulosus snurportin 1 0.0336 0.0833 0.0831
Loa Loa (eye worm) hypothetical protein 0.0201 0.0484 0.0482
Mycobacterium ulcerans beta-lactamase 0.0036 0.0059 0.0902
Entamoeba histolytica hypothetical protein 0.0072 0.0151 0.5895
Onchocerca volvulus 0.0025 0.0032 0.0028
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0032 0.003
Schistosoma mansoni tar DNA-binding protein 0.0208 0.0503 0.0501
Loa Loa (eye worm) prolyl oligopeptidase 0.0062 0.0127 0.0124
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0031
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0031
Brugia malayi hypothetical protein 0.0029 0.0042 0.0039
Schistosoma mansoni DNA helicase recq5 0.0022 0.0023 0.0021
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0032 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.1228
Loa Loa (eye worm) TAR-binding protein 0.0208 0.0503 0.0501
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0062 0.0127 0.0422
Schistosoma mansoni hypothetical protein 0.0046 0.0086 0.0084
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0011 0.0009
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0319 0.0316
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0048 0.0046
Echinococcus granulosus peptidase Clp S14 family 0.0166 0.0395 0.0392
Echinococcus multilocularis musashi 0.0117 0.0268 0.0266
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0004 0.0313
Onchocerca volvulus 0.0036 0.0059 0.0055
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.002 0.0019 0.0017
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0034 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0055 0.0108 0.0106
Echinococcus multilocularis muscleblind protein 0.0316 0.078 0.0778
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.002 0.0019 0.0017
Onchocerca volvulus 0.0083 0.018 0.0176
Brugia malayi hypothetical protein 0.0201 0.0484 0.0482
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0091 0.0088
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0132 0.013
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0007 0.0099
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0007 0.0518
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0004
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0059 0.4634
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.002 0.0019 0.0017
Onchocerca volvulus 0.002 0.0019 0.0015
Onchocerca volvulus Huntingtin homolog 0.0267 0.0654 0.0651
Loa Loa (eye worm) protein-tyrosine phosphatase 0.002 0.0019 0.0017
Echinococcus multilocularis tar DNA binding protein 0.0208 0.0503 0.0501
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0224 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Schistosoma mansoni thyroid hormone receptor 0.0055 0.0108 0.0106
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0007 0.0056
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.002 0.0019 0.0017
Echinococcus granulosus intermediate filament protein 0.0117 0.0268 0.0266
Echinococcus granulosus serotonin transporter 0.0149 0.0349 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0038 0.3002
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0024 0.0029 0.0027
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0007 0.0007
Brugia malayi prolyl oligopeptidase family protein 0.0263 0.0644 0.0641
Leishmania major hypothetical protein, conserved 0.0036 0.0059 0.0098
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0019 0.0017
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0055 0.0108 0.0106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0055 0.0108 0.0106
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0032 0.003
Echinococcus multilocularis GPCR, family 2 0.0051 0.0098 0.0095
Mycobacterium tuberculosis Conserved protein 0.0036 0.0059 0.1046
Echinococcus multilocularis 0.002 0.0019 0.0017
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.002 0.0019 0.0017
Plasmodium falciparum amino acid transporter, putative 0.0025 0.0032 0.047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0224 0.0221
Giardia lamblia Pyruvate kinase 0.0019 0.0017 0.119
Loa Loa (eye worm) hypothetical protein 0.0055 0.0108 0.0106
Mycobacterium tuberculosis Probable peptidase 0.0062 0.0127 0.2279
Brugia malayi F/Y-rich N-terminus family protein 0.0037 0.0063 0.006
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0127 0.0217
Brugia malayi hypothetical protein 0.002 0.0019 0.0017
Brugia malayi jmjC domain containing protein 0.0017 0.0011 0.0009
Plasmodium falciparum glutathione reductase 0.004 0.0071 0.1099
Brugia malayi nuclear hormone receptor family member odr-7 0.0026 0.0034 0.0031
Toxoplasma gondii FATC domain-containing protein 0.0019 0.0016 0.0045
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0048 0.0046
Brugia malayi steroid hormone receptor 0.0055 0.0108 0.0106
Schistosoma mansoni vesicular acetylcholine transporter 0.39 1 1
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0065 0.0062
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0031
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0263 0.0644 0.1121
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0016 0.0009 0.0096
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0007 0.0056
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0091 0.0088
Plasmodium falciparum peptidase, putative 0.0062 0.0127 0.2004
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0019 0.0017
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0083 0.018 0.0178
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0101 0.0099
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0101 0.1546
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0065 0.5101
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0062 0.0127 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0059 0.0056
Echinococcus multilocularis ferritin 0.0016 0.0009 0.0007
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.002 0.0019 0.0017
Leishmania major oligopeptidase b 0.0062 0.0127 0.0217
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0007 0.0004
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0066 0.521
Trypanosoma brucei C-8 sterol isomerase, putative 0.2238 0.5725 1
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0071 0.0068
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0102 0.023 0.4157
Brugia malayi Steroid receptor seven-up type 2 0.0055 0.0108 0.0106
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.0132 0.013
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0055 0.0108 0.0106
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.0003 0.0001
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.002 0.0019 0.0017
Schistosoma mansoni ferritin 0.0016 0.0009 0.0007
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0034 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.0007 0.0007
Brugia malayi RNA binding protein 0.0208 0.0503 0.0501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0007 0.0007
Brugia malayi nuclear hormone receptor 0.0026 0.0034 0.0031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0091 0.0088
Loa Loa (eye worm) hypothetical protein 0.0083 0.018 0.0178
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.1157 0.2944 0.2942
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.003 0.0043 0.0764
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Leishmania major hypothetical protein, conserved 0.0017 0.0011 0.0015
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.002 0.0019 0.0017
Schistosoma mansoni growth factor receptor-bound protein 0.0122 0.028 0.0278
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0055 0.0108 0.0106
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0303 0.0746 0.0744
Loa Loa (eye worm) hypothetical protein 0.0052 0.0101 0.0099
Echinococcus multilocularis pyruvate kinase 0.0038 0.0065 0.0062
Toxoplasma gondii thioredoxin reductase 0.004 0.0071 0.0233
Entamoeba histolytica protein tyrosine phosphatase, putative 0.002 0.0019 0.0659
Loa Loa (eye worm) RecQ helicase 0.0022 0.0023 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0005 0.0409
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Brugia malayi jmjC domain containing protein 0.0017 0.0011 0.0009
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0042 0.0039
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.003 0.0043 0.0041
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0007 0.0004
Schistosoma mansoni hypothetical protein 0.0105 0.0238 0.0235
Onchocerca volvulus 0.002 0.0019 0.0015
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0263 0.0644 0.1121
Trypanosoma brucei oligopeptidase b 0.0062 0.0127 0.0217
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0192 0.3063
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0027 0.0385
Trypanosoma cruzi C-8 sterol isomerase, putative 0.2238 0.5725 1
Trichomonas vaginalis hypothetical protein 0.0015 0.0005 0.0409
Brugia malayi conserved hypotetical protein 0.0026 0.0034 0.0031
Trichomonas vaginalis glutathione reductase, putative 0.0014 0.0003 0.0244
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0015 0.0005 0.0005
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0004 0.0003
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.003 0.0043 0.3407
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0795 0.2013 0.2011
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0007 0.0007
Brugia malayi RNA, U transporter 1 0.009 0.0198 0.0195
Entamoeba histolytica hypothetical protein 0.0072 0.0151 0.5895
Brugia malayi jmjC domain containing protein 0.0064 0.0132 0.013
Onchocerca volvulus 0.002 0.0019 0.0015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0003 0.0001
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0011 0.0009
Onchocerca volvulus 0.002 0.0019 0.0015
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.002 0.0019 0.0017
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0066 0.521
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.002 0.0019 0.0017
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0025 0.0032 0.003
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0074 0.1142
Brugia malayi jmjC domain containing protein 0.0017 0.0011 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0034 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0066 0.0111
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0015 0.0007 0.0056
Schistosoma mansoni DNA helicase recq1 0.0022 0.0023 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.0224 0.0221
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0056
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0071 0.0068
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0065 0.2467
Loa Loa (eye worm) hypothetical protein 0.0055 0.0108 0.0106
Toxoplasma gondii ABC1 family protein 0.0036 0.0059 0.0191
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.002 0.0019 0.0017
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0019 0.0017
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0003 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0091 0.7152
Loa Loa (eye worm) protein-tyrosine phosphatase 0.002 0.0019 0.0017
Toxoplasma gondii histone lysine methyltransferase SET1 0.0234 0.0568 0.1924
Echinococcus multilocularis ecdysone induced protein 78C 0.0055 0.0108 0.0106
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0052 0.0101 0.1594
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0019 0.0017
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0026 0.0034 0.0031
Brugia malayi prolyl oligopeptidase family protein 0.0062 0.0127 0.0124
Echinococcus granulosus tar DNA binding protein 0.0208 0.0503 0.0501
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0062 0.0127 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0098 0.0095
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0034 0.003
Echinococcus granulosus Niemann Pick C1 protein 0.016 0.0378 0.0376
Onchocerca volvulus 0.002 0.0019 0.0015
Onchocerca volvulus Protein ultraspiracle homolog 0.0055 0.0108 0.0104
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0005 0.0405
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0015 0.0005 0.0005
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0062 0.0127 0.0217
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0038 0.3002
Loa Loa (eye worm) hypothetical protein 0.1144 0.291 0.2908
Mycobacterium tuberculosis Probable oxidoreductase 0.0102 0.023 0.4157
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0007 0.0056
Loa Loa (eye worm) hypothetical protein 0.0025 0.0032 0.003
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0016 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0038 0.3002
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.002 0.0019 0.0017
Treponema pallidum ATP-dependent RNA helicase 0.003 0.0043 0.065
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0019 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0224 0.0221
Echinococcus granulosus microtubule associated protein 2 0.1306 0.3327 0.3325
Brugia malayi Niemann-Pick C1 protein precursor 0.0112 0.0255 0.0252
Onchocerca volvulus 0.002 0.0019 0.0015
Brugia malayi beta-lactamase family protein 0.0036 0.0059 0.0056
Loa Loa (eye worm) protein-tyrosine phosphatase 0.002 0.0019 0.0017
Brugia malayi Glycosyl hydrolases family 31 protein 0.0173 0.0412 0.041
Loa Loa (eye worm) hypothetical protein 0.0267 0.0654 0.0652
Loa Loa (eye worm) prolyl oligopeptidase 0.0782 0.1979 0.1977
Plasmodium vivax pyruvate kinase, putative 0.0038 0.0065 0.0998
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0101 0.0099
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0254 0.062 0.0617
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0108 0.0106
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.0101 0.1594
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0038 0.3002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0033 0.2599
Brugia malayi hypothetical protein 0.0029 0.0042 0.0039
Trypanosoma brucei pyruvate kinase 1 0.0038 0.0065 0.0109
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0074 0.0242
Schistosoma mansoni cpg binding protein 0.0122 0.028 0.0278
Schistosoma mansoni steroid hormone receptor ad4bp 0.0055 0.0108 0.0106
Schistosoma mansoni ferritin 0.0016 0.0009 0.0007
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0003 0.0001
Echinococcus granulosus expressed protein 0.0016 0.0009 0.0007
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0004 0.0313
Loa Loa (eye worm) hypothetical protein 0.0055 0.0108 0.0106
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0039 0.0067 0.1044
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0015 0.0007 0.0056
Onchocerca volvulus 0.0157 0.037 0.0366
Entamoeba histolytica acyl-coA synthetase, putative 0.0052 0.0101 0.3922
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0098 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0055 0.0108 0.0106
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0007 0.0014
Toxoplasma gondii hypothetical protein 0.0025 0.0032 0.0101
Schistosoma mansoni hypothetical protein 0.011 0.0249 0.0247
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.002 0.0019 0.0017
Plasmodium vivax RNA helicase-1, putative 0.003 0.0043 0.065
Entamoeba histolytica protein tyrosine phosphatase, putative 0.002 0.0019 0.0659
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.016 0.038 0.0377
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0102 0.023 0.4157
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0019 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0055 0.0108 0.0106
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0066 0.0111
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0074 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0074 0.0071
Brugia malayi prolyl oligopeptidase family protein 0.0062 0.0127 0.0124
Onchocerca volvulus 0.002 0.0019 0.0015
Brugia malayi beta-lactamase 0.0036 0.0059 0.0056
Trypanosoma brucei protein tyrosine phosphatase 1 0.002 0.0019 0.0029
Loa Loa (eye worm) hypothetical protein 0.0054 0.0107 0.0105
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0092 0.0204 0.3216
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Entamoeba histolytica prolyl oligopeptidase family protein 0.0062 0.0127 0.4924
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0117 0.0268 0.0266
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0027 0.1968
Echinococcus granulosus survival motor neuron protein 1 0.0515 0.1293 0.1291
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0011 0.0009
Echinococcus multilocularis FTZ F1 alpha 0.0055 0.0108 0.0106
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0031
Onchocerca volvulus 0.002 0.0019 0.0015
Brugia malayi hypothetical protein 0.0515 0.1293 0.1291
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0062 0.1105
Loa Loa (eye worm) protein tyrosine phosphatase 0.002 0.0019 0.0017
Schistosoma mansoni nuclear hormone receptor 0.0055 0.0108 0.0106
Loa Loa (eye worm) hypothetical protein 0.0515 0.1293 0.1291
Loa Loa (eye worm) hypothetical protein 0.1157 0.2944 0.2942
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0014 0.0003 0.0001
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0011 0.0009
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0045 0.0042
Echinococcus multilocularis lamin 0.0117 0.0268 0.0266
Onchocerca volvulus 0.0036 0.0059 0.0055
Loa Loa (eye worm) hypothetical protein 0.0029 0.0042 0.0039
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0062 0.0127 0.0217
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0192 0.3063
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0032 0.003
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.002 0.0019 0.0029
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.002 0.0019 0.0017
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0039 0.0067 0.1044
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0083 0.018 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0055 0.0108 0.0106
Giardia lamblia Alanyl dipeptidyl peptidase 0.0062 0.0127 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.018 0.0178
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0015 0.0007 0.0056
Loa Loa (eye worm) hypothetical protein 0.0062 0.0127 0.0124
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0007 0.0004
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0005 0.0003
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.002 0.0019 0.0017
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0007 0.0099
Giardia lamblia Alanyl dipeptidyl peptidase 0.0062 0.0127 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0029 0.0042 0.0039
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0254 0.062 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0014 0.0003 0.0057
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0329 0.0326
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0004 0.0063
Loa Loa (eye worm) solute carrier family 6 member 4 0.0149 0.0349 0.0347
Brugia malayi Protein-tyrosine phosphatase 0.002 0.0019 0.0017
Echinococcus multilocularis protein patched 0.0048 0.0091 0.0088
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.002 0.0019 0.0017
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0016 0.0009 0.0144
Mycobacterium ulcerans lipase LipD 0.0036 0.0059 0.0902
Onchocerca volvulus 0.0025 0.0032 0.0028
Leishmania major GTP-binding protein, putative 0.0023 0.0027 0.0043
Echinococcus granulosus pyruvate kinase 0.0019 0.0017 0.0015
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0032 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0007 0.0056
Mycobacterium leprae Probable pyruvate kinase PykA 0.0038 0.0065 0.0947
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0004 0.0313
Leishmania major protein-tyrosine phosphatase 1-like protein 0.002 0.0019 0.0029
Echinococcus granulosus mixed lineage leukemia protein mll 0.003 0.0045 0.0042
Brugia malayi hypothetical protein 0.002 0.0019 0.0017
Mycobacterium ulcerans hypothetical protein 0.0036 0.0059 0.0902
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.002 0.0019 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Schistosoma mansoni growth factor receptor-bound protein 0.0122 0.028 0.0278
Echinococcus multilocularis acylamino acid releasing enzyme 0.0062 0.0127 0.0124
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0011 0.0015
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0016 0.0009 0.0144
Onchocerca volvulus 0.002 0.0019 0.0015
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0065 0.0109
Loa Loa (eye worm) hypothetical protein 0.0025 0.0032 0.003
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0007 0.0099
Toxoplasma gondii hypothetical protein 0.1157 0.2944 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0031
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0007 0.0004
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0023 0.0036
Loa Loa (eye worm) protein-tyrosine phosphatase 0.002 0.0019 0.0017
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0056 0.0112 0.011
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0023 0.165
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.0412 0.041
Echinococcus granulosus FTZ F1 alpha 0.0055 0.0108 0.0106
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0034 0.0031
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.003 0.0043 0.0071
Plasmodium falciparum transporter, putative 0.0025 0.0032 0.047
Loa Loa (eye worm) hypothetical protein 0.0025 0.0032 0.003
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0087 0.0192 0.3063
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0065 0.5101
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0011 0.0009
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.002 0.0019 0.0029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0006
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0071 0.1099
Onchocerca volvulus 0.01 0.0225 0.0221
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0025 0.0031 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0055 0.0108 0.0106
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0048 0.008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0062 0.1105
Echinococcus multilocularis pyruvate kinase 0.003 0.0044 0.0042
Toxoplasma gondii hypothetical protein 0.0025 0.0032 0.0101
Echinococcus multilocularis mixed lineage leukemia protein mll 0.003 0.0045 0.0042
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0025 0.0032 0.003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.003 0.0045 0.0042
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0034 0.0031
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.003 0.0043 0.0071
Brugia malayi nuclear receptor RXR 0.0029 0.0042 0.0039
Brugia malayi jmjC domain containing protein 0.0071 0.015 0.0148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0055 0.0108 0.0106
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0007 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Schistosoma mansoni myst-related protein 0.0014 0.0004 0.0002
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0059 0.1046
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0015 0.0007 0.0056
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0059 0.1046
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0224 0.0221
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0048 0.0046
Onchocerca volvulus 0.0036 0.0059 0.0055
Trichomonas vaginalis mercuric reductase, putative 0.0014 0.0003 0.0244
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0038 0.3002
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0254 0.062 0.2098
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.0132 0.013
Schistosoma mansoni lamin 0.0117 0.0268 0.0266
Schistosoma mansoni protein tyrosine phosphatase 0.002 0.0019 0.0017
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0062 0.0127 0.0124
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0325 0.0802 0.08
Brugia malayi Dual specificity protein phosphatase CDC14B 0.002 0.0019 0.0017
Brugia malayi Muscleblind-like protein 0.0316 0.078 0.0778
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0029 0.0042 0.0039
Toxoplasma gondii prolyl endopeptidase 0.0062 0.0127 0.0422
Loa Loa (eye worm) hypothetical protein 0.0029 0.0042 0.0039
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0092 0.0204 0.3678
Loa Loa (eye worm) hypothetical protein 0.0029 0.0042 0.0039
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0009
Brugia malayi nuclear receptor NHR-88 0.0026 0.0034 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0127 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0059 0.0098
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0019 0.0017
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.002 0.0019 0.0017
Schistosoma mansoni hypothetical protein 0.0881 0.2234 0.2232
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0056 0.0112 0.011
Plasmodium falciparum acyl-CoA synthetase 0.0039 0.0067 0.1044
Schistosoma mansoni importin beta-1 0.0032 0.0048 0.0046
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0062 0.0127 0.4924
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0056
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.0108 0.0106
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.002 0.0019 0.0017
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0027 0.0024
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0023 0.0036
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0062 0.0127 0.0217
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0782 0.1979 0.1977
Schistosoma mansoni ferritin light chain 0.0016 0.0009 0.0007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0059 0.0056
Schistosoma mansoni high-affinity choline transporter 0.0083 0.018 0.0178
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0336 0.0833 0.0831
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.003 0.0043 0.3407
Echinococcus granulosus eukaryotic initiation factor 4A 0.003 0.0043 0.0041
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0092 0.0204 0.3678
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0019 0.0017
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0015 0.0007 0.0056
Loa Loa (eye worm) hypothetical protein 0.0062 0.0127 0.0124
Echinococcus granulosus vesicular acetylcholine transporter 0.39 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0003 0.0001
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0074 0.5804
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0066 0.521
Echinococcus multilocularis survival motor neuron protein 1 0.0515 0.1293 0.1291
Loa Loa (eye worm) hypothetical protein 0.0038 0.0065 0.0062
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0166 0.0395 0.7147
Brugia malayi orphan nuclear receptor NR2E1 0.0026 0.0034 0.0031
Schistosoma mansoni zinc finger protein 0.0026 0.0034 0.0031
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0056
Schistosoma mansoni pyruvate kinase 0.0038 0.0065 0.0062
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0114 0.0259 0.0257
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0027 0.0083
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0059 0.085
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0016 0.0023
Onchocerca volvulus 0.0149 0.0349 0.0346
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0033 0.2599
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0007 0.0056
Onchocerca volvulus 0.0025 0.0032 0.0028
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0004 0.0003
Echinococcus multilocularis dnaJ subfamily B 0.1731 0.4421 0.4419
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Brugia malayi nuclear receptor NHR-88 0.0055 0.0108 0.0106
Echinococcus granulosus phd:f box containing protein 0.0017 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0055 0.0108 0.0106
Leishmania major pyruvate kinase 0.0038 0.0065 0.0109
Loa Loa (eye worm) glutathione reductase 0.004 0.0071 0.0068
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.0552 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0038 0.0064 0.0062
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0011 0.0009
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0032 0.003
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0007 0.0099
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0052 0.0101 0.1594
Plasmodium falciparum pyruvate kinase 0.0038 0.0065 0.0998
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0029 0.0042 0.0039
Mycobacterium ulcerans pyruvate kinase 0.0038 0.0065 0.0998
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0032 0.003
Onchocerca volvulus Bile acid receptor homolog 0.0055 0.0108 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.002 0.0019 0.0017
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0263 0.0644 0.1121
Plasmodium falciparum thioredoxin reductase 0.004 0.0071 0.1099
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.002 0.0019 0.0017
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0151 0.0149
Echinococcus granulosus sodium:glucose cotransporter 2 0.0325 0.0802 0.08
Loa Loa (eye worm) acetyltransferase 0.0141 0.0329 0.0326
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0026 0.0034 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.0108 0.0106
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.0007 0.0014
Schistosoma mansoni survival motor neuron protein 0.0105 0.0238 0.0235
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0059 0.0056
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0023 0.0036
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0007 0.0004
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.002 0.0019 0.0017
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0027 0.0043
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0019 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0038 0.3002
Loa Loa (eye worm) nuclear hormone receptor 0.0026 0.0034 0.0031
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0056
Plasmodium vivax JmjC domain containing protein 0.0017 0.0011 0.0131
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0027 0.0024
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0042 0.0039
Echinococcus granulosus lamin 0.0117 0.0268 0.0266
Loa Loa (eye worm) RNA binding protein 0.0208 0.0503 0.0501
Loa Loa (eye worm) hypothetical protein 0.0039 0.0067 0.0065
Plasmodium vivax amine transporter, putative 0.0025 0.0032 0.047
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0004 0.0313
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0007 0.0004
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0023 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0173 0.0412 0.041
Brugia malayi hypothetical protein 0.0072 0.0151 0.0149
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0019 0.0017
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0007 0.0099
Giardia lamblia Pyruvate kinase 0.0038 0.0065 0.5007
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.002 0.0019 0.0017
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.002 0.0019 0.0017
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0101 0.0173
Schistosoma mansoni hypothetical protein 0.0051 0.0098 0.0095
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0007 0.0518
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0032 0.003
Echinococcus granulosus growth factor receptor bound protein 2 0.0122 0.028 0.0278
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0052 0.0101 0.182
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0782 0.1979 0.1976
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0031
Brugia malayi Calcitonin receptor-like protein seb-1 0.016 0.038 0.0377
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0015 0.0007 0.0056
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.003 0.0043 0.1615
Schistosoma mansoni peptidase Clp (S14 family) 0.0254 0.062 0.0617
Schistosoma mansoni ferritin 0.0016 0.0009 0.0007
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.002 0.0019 0.0017
Toxoplasma gondii propionate-CoA ligase 0.0015 0.0007 0.0014
Brugia malayi Pyruvate kinase, M2 isozyme 0.0038 0.0065 0.0062
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0016 0.0009 0.004
Mycobacterium ulcerans bacterioferritin BfrA 0.0016 0.0009 0.0096
Brugia malayi Intermediate filament tail domain containing protein 0.0117 0.0268 0.0266
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0032 0.003
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0065 0.0061
Loa Loa (eye worm) hypothetical protein 0.0054 0.0107 0.0105
Toxoplasma gondii NADPH-glutathione reductase 0.0014 0.0003 0.0002
Schistosoma mansoni ap endonuclease 0.0015 0.0005 0.0003
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0011 0.0009
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0015 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0055 0.0108 0.0106
Echinococcus multilocularis hypothetical protein 0.002 0.0019 0.0017
Onchocerca volvulus 0.002 0.0019 0.0015
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0062 0.0127 0.0124
Loa Loa (eye worm) protein-tyrosine phosphatase 0.002 0.0019 0.0017
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0101 0.0173
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0027 0.0043
Schistosoma mansoni inositol transporter 0.0325 0.0802 0.08
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Echinococcus granulosus protein tyrosine phosphatase n9 0.002 0.0019 0.0017
Echinococcus granulosus pyruvate kinase 0.0019 0.0017 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.002 0.0019 0.0017
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0032 0.0101
Plasmodium vivax glutathione reductase, putative 0.004 0.0071 0.1099
Onchocerca volvulus 0.002 0.0019 0.0015
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0059 0.0056
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0025 0.0031 0.0029
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0034 0.0031
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0066 0.0064
Onchocerca volvulus 0.002 0.0019 0.0015
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0316 0.078 0.0778
Loa Loa (eye worm) hypothetical protein 0.0115 0.0263 0.026
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0048 0.0156
Treponema pallidum bacterioferrin (TpF1) 0.0016 0.0009 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.0108 0.0106
Echinococcus granulosus sodium:glucose cotransporter 0.0325 0.0802 0.08
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.002 0.0019 0.0017
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.0005 0.0003
Schistosoma mansoni myst-related protein 0.0014 0.0004 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0127 0.0217
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0065 0.0061
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0015 0.0007 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0038 0.3002
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0034 0.0031
Brugia malayi jmjC domain containing protein 0.0017 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Schistosoma mansoni nuclear receptor 0.0026 0.0034 0.0031
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0254 0.062 1
Brugia malayi latrophilin 2 splice variant baaae 0.011 0.0249 0.0247
Echinococcus multilocularis microtubule associated protein 2 0.1306 0.3327 0.3325
Schistosoma mansoni alpha-glucosidase 0.0149 0.035 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Toxoplasma gondii exonuclease III APE 0.0015 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0039 0.0067 0.0065
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0055 0.0108 0.0106
Onchocerca volvulus 0.0117 0.0268 0.0264
Onchocerca volvulus 0.0122 0.028 0.0276
Trichomonas vaginalis helicase, putative 0.0028 0.0038 0.3002
Echinococcus granulosus muscleblind protein 0.0316 0.078 0.0778
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0066 0.521
Plasmodium falciparum zinc finger protein, putative 0.0014 0.0004 0.0016
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.002 0.0019 0.0017
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0098 0.0095
Brugia malayi beta-lactamase family protein 0.0036 0.0059 0.0056
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0101 0.0099
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0025 0.0031 0.0029
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0045 0.0042
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0024 0.0029 0.0027
Echinococcus multilocularis lamin dm0 0.0117 0.0268 0.0266
Brugia malayi GH02984p 0.0083 0.018 0.0178
Brugia malayi nuclear receptor NHR-67 0.0026 0.0034 0.0031
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.003 0.0043 0.0039
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0112 0.0255 1
Leishmania major trypanothione reductase 0.004 0.0071 0.012
Echinococcus multilocularis vesicular acetylcholine transporter 0.39 1 1
Brugia malayi intermediate filament protein 0.0117 0.0268 0.0266
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0014 0.0003 0.0001
Treponema pallidum exodeoxyribonuclease (exoA) 0.0015 0.0005 0.0033
Loa Loa (eye worm) hypothetical protein 0.0029 0.0042 0.0039
Loa Loa (eye worm) hypothetical protein 0.0157 0.037 0.0368
Trichomonas vaginalis pten, drome, putative 0.002 0.0019 0.1502
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0015 0.0005 0.022
Leishmania major tyrosine specific protein phosphatase, putative 0.002 0.0019 0.0029
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0166 0.0395 0.7147
Schistosoma mansoni RAR-like nuclear receptor 0.0055 0.0108 0.0106
Echinococcus granulosus ecdysone induced protein 78C 0.0055 0.0108 0.0106
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.002 0.0019 0.0017
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0059 0.1046
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0004 0.0002
Entamoeba histolytica hypothetical protein 0.0072 0.0151 0.5895
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0027 0.0043
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.003 0.0043 0.0041
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.002 0.0019 0.0017
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0098 0.0095
Schistosoma mansoni pyruvate kinase 0.0038 0.0065 0.0062
Echinococcus granulosus pyruvate kinase 0.0038 0.0065 0.0062
Loa Loa (eye worm) hypothetical protein 0.0025 0.0032 0.003
Onchocerca volvulus 0.002 0.0019 0.0015
Loa Loa (eye worm) hypothetical protein 0.003 0.0043 0.0041
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0254 0.062 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0108 0.0106
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0048 0.008
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0007 0.0056
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0034 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0003 0.0001
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.003 0.0043 0.0071
Schistosoma mansoni apoferritin-2 0.0016 0.0009 0.0007
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0017 0.005
Echinococcus granulosus tachykinin peptides receptor 99D 0.0303 0.0746 0.0744
Brugia malayi tailless protein 0.0026 0.0034 0.0031
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0795 0.2013 0.2011
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0254 0.062 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0055 0.0108 0.0104
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0254 0.062 1
Onchocerca volvulus 0.002 0.0019 0.0015
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0059 0.1046
Echinococcus multilocularis pyruvate kinase 0.0019 0.0017 0.0015
Echinococcus granulosus GPCR family 2 0.0051 0.0098 0.0095
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0066 0.521
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0055 0.0108 0.0106
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0059 0.1046
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.002 0.0019 0.0017
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0263 0.0644 0.1121
Loa Loa (eye worm) histone methyltransferase 0.0038 0.0064 0.0062
Entamoeba histolytica hypothetical protein 0.0026 0.0033 0.1209
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.002 0.0019 0.0017
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.002 0.0019 0.0017
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0007 0.0099
Echinococcus multilocularis growth factor receptor bound protein 2 0.0122 0.028 0.0278
Echinococcus granulosus importin subunit beta 1 0.0032 0.0048 0.0046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0108 0.0106
Schistosoma mansoni sodium/chloride dependent transporter 0.0149 0.0349 0.0347
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0062 0.0127 0.1959
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0023 0.0321
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.0224 0.0221
Mycobacterium leprae Probable lipase LipE 0.0036 0.0059 0.085
Echinococcus multilocularis protein tyrosine phosphatase n9 0.002 0.0019 0.0017
Onchocerca volvulus 0.0117 0.0268 0.0264
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0063 0.0128 0.0126
Echinococcus granulosus Niemann Pick C1 protein 0.0112 0.0255 0.0252
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0019 0.0017
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.002 0.0019 0.0029
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0048 0.0046
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0059 0.0902
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0055 0.0108 0.0106
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0102 0.023 0.3646
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0032 0.003
Echinococcus granulosus serine protein kinase ATM 0.0019 0.0016 0.0013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0031
Schistosoma mansoni hypothetical protein 0.0072 0.0151 0.0149
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0048 0.0728
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0004 0.0003
Onchocerca volvulus 0.0015 0.0007 0.0003
Brugia malayi Protein-tyrosine phosphatase 0.002 0.0019 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Loa Loa (eye worm) protein-tyrosine phosphatase 0.002 0.0019 0.0017
Brugia malayi hypothetical protein 0.002 0.0019 0.0017
Mycobacterium tuberculosis Probable dehydrogenase 0.0092 0.0204 0.3678
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0003 0.0001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.016 0.038 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0038 0.3002
Loa Loa (eye worm) protein-tyrosine phosphatase 0.002 0.0019 0.0017
Schistosoma mansoni intermediate filament proteins 0.0117 0.0268 0.0266
Onchocerca volvulus 4.1 G protein, putative homolog 0.002 0.0019 0.0015
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0038 0.0065 0.1153
Echinococcus multilocularis eukaryotic initiation factor 4A 0.003 0.0043 0.0041
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0003 0.0001
Brugia malayi eukaryotic initiation factor 4A 0.003 0.0043 0.0041
Loa Loa (eye worm) hypothetical protein 0.0062 0.0127 0.0124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0038 0.3002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0101 0.3922
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0029 0.0042 0.0039
Brugia malayi hypothetical protein 0.0026 0.0034 0.0031
Onchocerca volvulus 0.002 0.0019 0.0015
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0004 0.0313
Onchocerca volvulus 0.0015 0.0007 0.0003
Echinococcus multilocularis cpg binding protein 0.0128 0.0298 0.0295
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1759 0.4493 0.4492
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0038 0.0064 0.0062
Schistosoma mansoni thyroid hormone receptor 0.0055 0.0108 0.0106
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.002 0.0019 0.0017
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0782 0.1979 0.1977
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0055 0.0108 0.0106
Echinococcus granulosus solute carrier family 5 0.0325 0.0802 0.08
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0062 0.1105
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0003 0.0001
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0017 0.0228
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0011 0.0015
Schistosoma mansoni alpha glucosidase 0.0038 0.0066 0.0064
Loa Loa (eye worm) hypothetical protein 0.011 0.0249 0.0247
Schistosoma mansoni coup transcription factor 0.0055 0.0108 0.0106
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0003 0.0001
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0101 0.1546
Brugia malayi ERG2 and Sigma1 receptor like protein 0.2238 0.5725 0.5724
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0011 0.0009
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0795 0.2013 0.2011
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0023 0.0021
Schistosoma mansoni ran 0.0023 0.0027 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0014 0.0003 0.0002
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.002 0.0019 0.0017
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0032 0.003
Schistosoma mansoni ferritin light chain 0.0016 0.0009 0.0007
Trypanosoma brucei trypanothione reductase 0.004 0.0071 0.012
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0005 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Plasmodium falciparum importin beta, putative 0.0032 0.0048 0.0733
Onchocerca volvulus 0.002 0.0019 0.0015
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0025 0.0031 0.0029
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0066 0.0064
Loa Loa (eye worm) hypothetical protein 0.0055 0.0108 0.0106
Loa Loa (eye worm) protein-tyrosine phosphatase 0.002 0.0019 0.0017
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.002 0.0019 0.0017
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0026 0.0034 0.0031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0038 0.3002
Plasmodium vivax importin-beta 2, putative 0.0032 0.0048 0.0733
Schistosoma mansoni alpha-glucosidase 0.0149 0.035 0.0348
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0325 0.0802 0.08
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Brugia malayi prolyl oligopeptidase family protein 0.0782 0.1979 0.1977
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0048 0.0046
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0048 0.0046
Echinococcus granulosus ferritin 0.0016 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0056
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0122 0.028 0.0278
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0098 0.0095
Loa Loa (eye worm) protein-tyrosine phosphatase 0.002 0.0019 0.0017
Loa Loa (eye worm) nuclear receptor NHR-67 0.0026 0.0034 0.0031
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0038 0.3002
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.003 0.0043 0.0041
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0019 0.0017
Schistosoma mansoni hypothetical protein 0.1731 0.4421 0.4419
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0224 0.0221
Schistosoma mansoni tar DNA-binding protein 0.0208 0.0503 0.0501
Toxoplasma gondii pyruvate kinase PyK1 0.0038 0.0065 0.0211
Treponema pallidum sodium- and chloride- dependent transporter 0.0149 0.0349 0.5617
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0007 0.0007
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0048 0.0046
Loa Loa (eye worm) hypothetical protein 0.0149 0.0349 0.0347
Schistosoma mansoni nuclear receptor 0.0026 0.0034 0.0031
Schistosoma mansoni hypothetical protein 0.0051 0.0098 0.0095
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0038 0.3002
Brugia malayi isocitrate dehydrogenase 0.0031 0.0048 0.0046
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0023 0.007
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Giardia lamblia Protein tyrosine phosphatase 0.002 0.0019 0.1339
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0055 0.0108 0.0106
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0782 0.1979 0.1977
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0019 0.0017
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0015 0.0005 0.0073
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0023 0.1808
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0007 0.0004
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0254 0.062 1
Mycobacterium ulcerans hypothetical protein 0.0052 0.0101 0.1594
Schistosoma mansoni apoferritin-2 0.0016 0.0009 0.0007
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0059 0.4634
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0098 0.0095
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0019 0.0017
Echinococcus multilocularis geminin 0.0881 0.2234 0.2232
Echinococcus multilocularis solute carrier family 5 0.0325 0.0802 0.08
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0166 0.0395 0.6333
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0003 0.0001
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0066 0.521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0224 0.0221
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0065 0.0109
Brugia malayi nuclear receptor RXR 0.0026 0.0034 0.0031
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.0303 0.0301
Entamoeba histolytica hypothetical protein 0.0014 0.0004 0.0066
Loa Loa (eye worm) hypothetical protein 0.2238 0.5725 0.5724
Loa Loa (eye worm) hypothetical protein 0.0117 0.0268 0.0266
Loa Loa (eye worm) hypothetical protein 0.0022 0.0023 0.0021
Loa Loa (eye worm) norepinephrine transporter 0.0149 0.0349 0.0347
Leishmania major importin beta-1 subunit, putative 0.0026 0.0033 0.0053
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0025 0.0031 0.0029
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.002 0.0019 0.0017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0062 0.1105
Schistosoma mansoni ran 0.0023 0.0027 0.0024
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0004 0.0313
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0048 0.0046
Echinococcus multilocularis prolyl endopeptidase 0.0062 0.0127 0.0124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0038 0.3002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0031
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0254 0.062 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0065 0.0999
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0004 0.0003
Mycobacterium ulcerans acetyl-CoA synthetase 0.0015 0.0007 0.0056
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0027 0.0385
Brugia malayi RNA recognition motif domain containing protein 0.0208 0.0503 0.0501
Trichomonas vaginalis ferritin, putative 0.0016 0.0009 0.0714
Onchocerca volvulus Prolyl endopeptidase homolog 0.0062 0.0127 0.0123
Onchocerca volvulus 0.0015 0.0007 0.0003
Echinococcus multilocularis thyroid hormone receptor alpha 0.0055 0.0108 0.0106
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.0007 0.0056
Echinococcus multilocularis expressed conserved protein 0.0105 0.0237 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0038 0.3002
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0023 0.0813
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0033 0.0053
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.0007 0.0165
Plasmodium falciparum eukaryotic initiation factor 4A 0.003 0.0043 0.065
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0055 0.0108 0.0106
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0026 0.0034 0.0031
Loa Loa (eye worm) hypothetical protein 0.0316 0.078 0.0778
Brugia malayi photoreceptor-specific nuclear receptor 0.0055 0.0108 0.0106
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.002 0.0019 0.0017
Echinococcus granulosus expressed conserved protein 0.0105 0.0237 0.0235
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0149 0.0349 0.0347
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0066 0.252
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0032 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Echinococcus multilocularis serine protein kinase ATM 0.0019 0.0016 0.0013
Loa Loa (eye worm) hypothetical protein 0.0059 0.0118 0.0116
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.0108 0.0106
Loa Loa (eye worm) steroid hormone receptor 0.0055 0.0108 0.0106
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0101 0.3922
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0048 0.0728
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.002 0.0019 0.0017
Toxoplasma gondii hypothetical protein 0.0087 0.0192 0.0644
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0066 0.252
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0007 0.0099
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0025 0.0032 0.003
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0023 0.1808
Loa Loa (eye worm) hypothetical protein 0.0112 0.0255 0.0252
Onchocerca volvulus 0.002 0.0019 0.0015
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.39 1 1
Leishmania major eukaryotic initiation factor 4a, putative 0.003 0.0043 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.002 0.0019 0.0017
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0048 0.0046
Loa Loa (eye worm) hypothetical protein 0.016 0.038 0.0377
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0059 0.4634
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0015 0.0007 0.0056
Brugia malayi hypothetical protein 0.002 0.0019 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Schistosoma mansoni cpg binding protein 0.0128 0.0298 0.0295
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0011 0.0009
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0303 0.0301
Echinococcus granulosus sodium:myo inositol cotransporter 0.0325 0.0802 0.08
Mycobacterium tuberculosis Conserved protein 0.0036 0.0059 0.1046
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0019 0.0017
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0017 0.0228
Loa Loa (eye worm) DR-78 0.0026 0.0034 0.0031
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.002 0.0019 0.0017
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0019 0.0017
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0031
Brugia malayi ecdysteroid receptor 0.0055 0.0108 0.0106
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Echinococcus granulosus Dipeptidyl peptidase 9 0.0263 0.0644 0.0641
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0059 0.0098
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0031
Schistosoma mansoni cpg binding protein 0.0128 0.0298 0.0295
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0055 0.0108 0.0106
Trichomonas vaginalis ran, putative 0.0023 0.0027 0.2119
Onchocerca volvulus 0.0052 0.0101 0.0097
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0003 0.0001
Echinococcus multilocularis nuclear receptor nhr 48 0.0026 0.0034 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0015 0.0005 0.0033
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0005 0.0405
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0023 0.0021
Loa Loa (eye worm) protein-tyrosine phosphatase 0.002 0.0019 0.0017
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0048 0.0155
Loa Loa (eye worm) hypothetical protein 0.0149 0.0349 0.0347
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0023 0.0021
Onchocerca volvulus 0.002 0.0019 0.0015
Schistosoma mansoni patched 1 0.0048 0.0091 0.0088
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0025 0.0032 0.003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0048 0.0046
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0032 0.003
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0025 0.0031 0.0029
Schistosoma mansoni hypothetical protein 0.0881 0.2234 0.2232
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0091 0.0088
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0019 0.0016 0.0023
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0092 0.0204 0.3678
Entamoeba histolytica Ran family GTPase 0.0023 0.0027 0.0969
Loa Loa (eye worm) hypothetical protein 0.0267 0.0654 0.0652
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0098 0.0095
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.39 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0032 0.003
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.015 0.0148
Echinococcus multilocularis snurportin 1 0.0336 0.0833 0.0831
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Brugia malayi hypothetical protein 0.0025 0.0032 0.003
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0062 0.0127 0.2004
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0004 0.0313
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0023 0.0321
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0055 0.0108 0.0106
Schistosoma mansoni sodium-dependent amino acid transporter 0.0025 0.0032 0.003
Schistosoma mansoni nuclear receptor nhr-48 0.0026 0.0034 0.0031
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0019 0.0017
Brugia malayi Probable ClpP-like protease 0.0254 0.062 0.0617
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0059 0.0098
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0101 0.1594
Schistosoma mansoni ap endonuclease 0.0015 0.0005 0.0003
Trypanosoma cruzi oligopeptidase b 0.0062 0.0127 0.0217
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0127 0.2004
Brugia malayi Sodium:solute symporter family protein 0.0083 0.018 0.0178
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0066 0.521
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0019 0.0017
Schistosoma mansoni rgs-gaip interacting protein gipc 0.002 0.0019 0.0017
Echinococcus granulosus eukaryotic initiation factor 4A III 0.003 0.0043 0.0041
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0055 0.0108 0.0106
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0108 0.0106
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0048 0.008
Entamoeba histolytica prolyl oligopeptidase family protein 0.0062 0.0127 0.4924
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Onchocerca volvulus Huntingtin homolog 0.0267 0.0654 0.0651
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0254 0.062 1
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0007 0.0004
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0074 0.5804
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Schistosoma mansoni lamin 0.0117 0.0268 0.0266
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0011 0.0009
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0208 0.0503 0.0501
Brugia malayi CXXC zinc finger family protein 0.0122 0.028 0.0278
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0059 0.0902
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.002 0.0019 0.0659
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0108 0.0106
Echinococcus multilocularis expressed protein 0.0016 0.0009 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Schistosoma mansoni inositol transporter 0.0325 0.0802 0.08
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0062 0.0127 0.0217
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0048 0.008
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0033 0.2599
Trypanosoma brucei pyruvate kinase 1, putative 0.0038 0.0065 0.0109
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0023 0.0021
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0263 0.0644 0.0641
Schistosoma mansoni hypothetical protein 0.0046 0.0086 0.0084
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0083 0.018 0.0605
Brugia malayi hypothetical protein 0.0157 0.037 0.0368
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0034 0.0031
Echinococcus multilocularis Niemann Pick C1 protein 0.0112 0.0255 0.0252
Brugia malayi hypothetical protein 0.002 0.0019 0.0017
Schistosoma mansoni hypothetical protein 0.0051 0.0098 0.0095
Schistosoma mansoni microtubule-associated protein tau 0.1306 0.3327 0.3325
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0009
Echinococcus multilocularis serotonin transporter 0.0149 0.0349 0.0347
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0065 0.0061
Echinococcus multilocularis pyruvate kinase 0.0038 0.0065 0.0062
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0263 0.0644 0.0641
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0019 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Brugia malayi nuclear hormone receptor 0.0055 0.0108 0.0106
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0038 0.3002
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0026 0.0034 0.0031
Brugia malayi Importin beta-1 subunit 0.0032 0.0048 0.0046
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0059 0.4634
Echinococcus granulosus pyruvate kinase 0.0019 0.0017 0.0015
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0026 0.0034 0.0031
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0092 0.0204 0.3678
Onchocerca volvulus 0.002 0.0019 0.0015
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0795 0.2013 0.2011
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0023 0.0021
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0019 0.0016 0.0013
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0091 0.0088
Loa Loa (eye worm) intermediate filament protein 0.0117 0.0268 0.0266
Loa Loa (eye worm) hypothetical protein 0.0052 0.0101 0.0099
Mycobacterium ulcerans bacterioferritin BfrB 0.0016 0.0009 0.0096
Echinococcus granulosus bloom syndrome protein 0.0022 0.0023 0.0021
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.002 0.0019 0.0017
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0066 0.521
Brugia malayi glutathione reductase 0.004 0.0071 0.0068
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0025 0.0032 0.047
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0023 0.0021
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0025 0.0031 0.0029
Schistosoma mansoni hypothetical protein 0.0051 0.0098 0.0095
Schistosoma mansoni retinoic acid receptor RXR 0.0055 0.0108 0.0106
Loa Loa (eye worm) protein-tyrosine phosphatase 0.002 0.0019 0.0017
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0065 0.0062
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0032 0.003
Echinococcus granulosus thyroid hormone receptor alpha 0.0026 0.0034 0.0031
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.0412 0.041
Echinococcus multilocularis pyruvate kinase 0.0019 0.0017 0.0015
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0007 0.0099
Brugia malayi cytoplasmic intermediate filament protein 0.0063 0.0128 0.0126
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.003 0.0043 0.3407
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0007 0.0007
Toxoplasma gondii hypothetical protein 0.0062 0.0127 0.0422
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0062 0.0127 0.0124
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0025 0.0032 0.003
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0025 0.0032 0.003
Echinococcus granulosus high affinity choline transporter 1 0.0083 0.018 0.0178
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.0033
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.003 0.0043 0.0139
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0059 0.0056
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0059 0.4634
Mycobacterium tuberculosis Conserved protein 0.0036 0.0059 0.1046
Schistosoma mansoni receptor protein tyrosine phosphatase 0.002 0.0019 0.0017
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0059 0.1046
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.0132 0.013
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0005 0.0033
Schistosoma mansoni sodium/solute symporter 0.0083 0.018 0.0178
Echinococcus multilocularis pyruvate kinase 0.0019 0.0017 0.0015
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0066 0.521
Loa Loa (eye worm) hypothetical protein 0.1157 0.2944 0.2942
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0062 0.0127 0.4924
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0048 0.0851
Loa Loa (eye worm) hypothetical protein 0.0149 0.0349 0.0347
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0007 0.0056
Entamoeba histolytica prolyl oligopeptidase family protein 0.0062 0.0127 0.4924
Echinococcus multilocularis muscleblind protein 1 0.0316 0.078 0.0778
Schistosoma mansoni protein tyrosine phosphatase 0.002 0.0019 0.0017
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0032 0.003
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0011 0.003
Onchocerca volvulus 0.0015 0.0007 0.0003
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0011 0.003
Schistosoma mansoni tar DNA-binding protein 0.0208 0.0503 0.0501
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0026 0.0034 0.0031
Leishmania major C-8 sterol isomerase-like protein 0.2238 0.5725 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0066 0.0216
Schistosoma mansoni hypothetical protein 0.0336 0.0833 0.0831
Entamoeba histolytica hypothetical protein, conserved 0.0062 0.0127 0.4924
Loa Loa (eye worm) hypothetical protein 0.0052 0.0101 0.0099
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0023 0.1808
Trypanosoma brucei glucosidase, putative 0.0038 0.0066 0.0111
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0032 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0055 0.0108 0.0106
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0254 0.062 0.0617
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0014 0.0003 0.0036
Brugia malayi nuclear hormone receptor family member nhr-6 0.0026 0.0034 0.0031
Schistosoma mansoni hypothetical protein 0.0046 0.0086 0.0084
Brugia malayi prolyl oligopeptidase family protein 0.0062 0.0127 0.0124
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0003 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0101 0.1594
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0032 0.003
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0048 0.008
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0014 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0004
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0254 0.062 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0038 0.3002
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0032 0.0101
Brugia malayi CHE-14 protein 0.0048 0.0091 0.0088
Trypanosoma brucei prolyl endopeptidase 0.0062 0.0127 0.0217
Brugia malayi ecdysone receptor 0.0026 0.0034 0.0031
Brugia malayi Protein-tyrosine phosphatase 1 0.002 0.0019 0.0017
Schistosoma mansoni sodium/chloride dependent transporter 0.0025 0.0032 0.003
Trypanosoma cruzi oligopeptidase b 0.0062 0.0127 0.0217
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0059 0.0902
Brugia malayi TAR-binding protein 0.0208 0.0503 0.0501
Brugia malayi hypothetical protein 0.0267 0.0654 0.0652
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0329 0.0326
Schistosoma mansoni pyruvate kinase 0.0019 0.0017 0.0015
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0042 0.0039
Loa Loa (eye worm) protein-tyrosine phosphatase 0.002 0.0019 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0224 0.0221
Giardia lamblia Translation initiation factor eIF-4A, putative 0.003 0.0043 0.328
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.002 0.0019 0.0017
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.002 0.0019 0.0017
Schistosoma mansoni tar DNA-binding protein 0.0208 0.0503 0.0501
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0035 0.0033
Echinococcus multilocularis peptidase Clp (S14 family) 0.0166 0.0395 0.0392
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0048 0.0155
Loa Loa (eye worm) hypothetical protein 0.0055 0.0108 0.0106
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0059 0.1046
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0066 0.0064
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0007 0.0007
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0032 0.003
Trichomonas vaginalis esterase, putative 0.0036 0.0059 0.4634
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0034 0.0031
Loa Loa (eye worm) hypothetical protein 0.1157 0.2944 0.2942
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0032 0.003
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0005 0.0409
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0258 0.063 0.0628
Echinococcus granulosus cpg binding protein 0.0128 0.0298 0.0295
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0052 0.0101 0.1594
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0007 0.0056
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0062 0.0127 0.2279
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0329 0.0326
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0101 0.182
Echinococcus granulosus lamin dm0 0.0117 0.0268 0.0266
Entamoeba histolytica hypothetical protein 0.0072 0.0151 0.5895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0007 0.0099
Echinococcus granulosus nuclear receptor nhr 48 0.0026 0.0034 0.0031
Schistosoma mansoni pcd6 interacting protein-related 0.002 0.0019 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.015 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.0108 0.0106
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0055 0.0108 0.0106
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0015 0.0005 0.0033
Schistosoma mansoni protein tyrosine phosphatase 0.002 0.0019 0.0017
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0055 0.0108 0.0106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0055 0.0108 0.0106
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0011 0.0131
Trypanosoma cruzi prolyl endopeptidase 0.0062 0.0127 0.0217
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0087 0.0192 0.3024
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0032 0.0101
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0066 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0017
Echinococcus granulosus acylamino acid releasing enzyme 0.0062 0.0127 0.0124
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0011 0.0009
Echinococcus multilocularis protein dispatched 1 0.0055 0.0108 0.0106
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0023 0.0021
Brugia malayi Thioredoxin reductase 0.004 0.0071 0.0068
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.015 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0189
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0149 0.0349 0.0347
Chlamydia trachomatis pyruvate kinase 0.0038 0.0065 0.0998
Loa Loa (eye worm) hypothetical protein 0.0025 0.0032 0.003
Brugia malayi Sex muscle abnormal protein 5 0.0122 0.028 0.0278
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0048 0.008
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0065 0.0062
Loa Loa (eye worm) hypothetical protein 0.0056 0.0112 0.011
Onchocerca volvulus 0.002 0.0019 0.0015
Loa Loa (eye worm) hypothetical protein 0.0039 0.0067 0.0065
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0027 0.0024
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0101 0.0173
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0056
Echinococcus granulosus lysosomal alpha glucosidase 0.0173 0.0412 0.041

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) > 5 uM Cytotoxicity against hepatoma cell line containing HCV replicon measured as change in GAPDH RNA level ChEMBL. 17004721
Activity (functional) > 5 uM Cytotoxicity against hepatoma cell line containing HCV replicon measured as change in GAPDH RNA level ChEMBL. 17004721
EC90 (functional) > 1 uM Inhibition of HCV replication in hepatocytes measured by cellular replicon assay ChEMBL. 17004721
Ki (binding) = 0.06 uM Binding affinity at HCV NS3 protease ChEMBL. 17004721
Ki (binding) = 0.06 uM Binding affinity at HCV NS3 protease ChEMBL. 17004721
Selectivity ratio (binding) = 45 Selectivity for human neutrophil elastase (HNE) over HCV NS3 protease ChEMBL. 17004721

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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