Detailed information for compound 460297

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 646.73 | Formula: C35H42N4O8
  • H donors: 4 H acceptors: 6 LogP: 2.29 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@H](C(=O)N1COC2([C@H]1C(=O)NCc1c(C)noc1C)CCCC2)C[C@H](C(=O)N[C@@H]1[C@H](O)COc2c1cccc2)Cc1ccccc1
  • InChi: 1S/C35H42N4O8/c1-21-26(22(2)47-38-21)18-36-33(43)31-35(14-8-9-15-35)46-20-39(31)34(44)27(40)17-24(16-23-10-4-3-5-11-23)32(42)37-30-25-12-6-7-13-29(25)45-19-28(30)41/h3-7,10-13,24,27-28,30-31,40-41H,8-9,14-20H2,1-2H3,(H,36,43)(H,37,42)/t24-,27+,28-,30+,31-/m1/s1
  • InChiKey: WLSFSMDYWCPRCG-WGHHUXKWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Protease Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Protease   99 aa 102 aa 32.4 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Protease   99 aa 102 aa 32.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus integrin beta 2 0.1903 0.3994 0.399
Trichomonas vaginalis cyclin B, putative 0.0301 0.0528 0.1246
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0079 0.0046 0.065
Plasmodium vivax vivapain-1 0.0099 0.0091 0.1211
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0147 0.0194 0.2197
Schistosoma mansoni tyrosine kinase 0.0507 0.0973 0.1138
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0097 0.0086 0.0499
Onchocerca volvulus 0.0494 0.0945 0.6898
Schistosoma mansoni neuropeptide F-like receptor 0.0494 0.0945 0.1106
Echinococcus granulosus allatostatin A receptor 0.0494 0.0945 0.094
Trypanosoma cruzi cyclin 6, putative 0.0565 0.1099 0.6742
Giardia lamblia Cyclin B-like protein 0.0073 0.0033 0.0113
Schistosoma mansoni serine/threonine protein kinase 0.0164 0.0232 0.0266
Brugia malayi EGF-like domain containing protein 0.006 0.0006 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.0281 0.0657
Trichomonas vaginalis cyclin B, putative 0.0073 0.0033 0.0066
Loa Loa (eye worm) hypothetical protein 0.006 0.0006 0.0009
Onchocerca volvulus 0.0077 0.0042 0.0306
Echinococcus granulosus calpain A 0.0271 0.0463 0.0457
Echinococcus granulosus cathepsin L cysteine proteinase 0.0187 0.0281 0.0275
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0081 0.0051 0.0275
Schistosoma mansoni z-protein (S1r protein) 0.0081 0.0051 0.0053
Loa Loa (eye worm) hypothetical protein 0.0565 0.1099 0.1595
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0417 0.0777 0.4758
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Entamoeba histolytica hypothetical protein 0.0073 0.0033 0.0275
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0215 0.0341 0.08
Brugia malayi Cyclin, N-terminal domain containing protein 0.0073 0.0033 0.0048
Plasmodium falciparum subtilisin-like protease 2 0.0147 0.0194 0.2666
Leishmania major cyclin 9, putative 0.0073 0.0033 0.0174
Leishmania major PFPI/DJ-1-like protein, putative 0.0443 0.0836 0.5116
Plasmodium vivax cyclin 4, putative 0.0073 0.0033 0.0392
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0097 0.0086 0.0192
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0528 0.1018 0.6242
Loa Loa (eye worm) melatonin receptor type 1A 0.0494 0.0945 0.1371
Schistosoma mansoni growth hormone secretagogue receptor 0.0494 0.0945 0.1106
Schistosoma mansoni ubiquitinyl hydrolase-BAP1 (C12 family) 0.0061 0.0007 0.0002
Schistosoma mansoni myosin xvIII 0.0494 0.0945 0.1106
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0494 0.0945 0.1106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0326 0.0581 0.3548
Toxoplasma gondii subtilisin SUB12 0.0204 0.0318 0.4467
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0061 0.0009 0.0003
Echinococcus multilocularis Ubiquitin thioesterase otubain protein 0.0084 0.0059 0.0053
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Loa Loa (eye worm) integrin beta-2 0.2577 0.5453 0.7908
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0494 0.0945 0.1371
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0017 0.0066
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0073 0.0033 0.0028
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0686 0.136 0.1355
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Trichomonas vaginalis hypothetical protein 0.0215 0.0341 0.08
Echinococcus granulosus G1:S specific cyclin D1 0.0073 0.0033 0.0028
Loa Loa (eye worm) hypothetical protein 0.0084 0.0059 0.0085
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0228 0.037 0.2246
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0191 0.0289 0.0334
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0129 0.0156 0.1393
Brugia malayi hypothetical protein 0.0494 0.0945 0.1371
Onchocerca volvulus Putative endochitinase 0.0307 0.0541 0.3948
Echinococcus multilocularis G1:S specific cyclin D1 0.0073 0.0033 0.0028
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0081 0.0051 0.0279
Brugia malayi Subtilase family protein 0.0147 0.0194 0.0281
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0105 0.0104 0.1392
Leishmania major cathepsin L-like protease 0.0187 0.0281 0.17
Trichomonas vaginalis conserved hypothetical protein 0.0665 0.1315 0.3126
Echinococcus granulosus single minded 2 0.0071 0.003 0.0024
Brugia malayi Stress-activated protein kinase jnk-1 0.0473 0.0899 0.1303
Trichomonas vaginalis cyclin D, putative 0.0301 0.0528 0.1246
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0456 0.0863 0.5288
Schistosoma mansoni ubiquitin-specific peptidase 10 (C19 family) 0.0129 0.0156 0.0177
Echinococcus multilocularis cysteine protease 0.0187 0.0281 0.0275
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0494 0.0945 0.094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.0091 0.0204
Loa Loa (eye worm) hypothetical protein 0.0236 0.0386 0.056
Echinococcus granulosus rhodopsin orphan GPCR 0.0494 0.0945 0.094
Loa Loa (eye worm) hypothetical protein 0.007 0.0027 0.0039
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0076 0.004 0.0489
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0147 0.0194 0.0222
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0494 0.0945 0.1371
Echinococcus multilocularis neuropeptide receptor 0.0494 0.0945 0.094
Trypanosoma cruzi pyroglutamyl-peptidase I, putative 0.0422 0.079 0.4837
Trichomonas vaginalis cyclin B, putative 0.0565 0.1099 0.2612
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0207 0.0324 0.1966
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0494 0.0945 0.1106
Echinococcus multilocularis fibrillin 1 0.0075 0.0039 0.0033
Onchocerca volvulus 0.0077 0.0042 0.0306
Brugia malayi Cyclin, N-terminal domain containing protein 0.0073 0.0033 0.0048
Brugia malayi sulfakinin receptor protein 0.0494 0.0945 0.1371
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase isozyme 0.0111 0.0116 0.011
Giardia lamblia Hypothetical protein 0.0073 0.0033 0.0113
Echinococcus multilocularis cathepsin L cysteine protease 0.0187 0.0281 0.0275
Brugia malayi putative neuropeptide receptor 0.0494 0.0945 0.1371
Onchocerca volvulus 0.0565 0.1099 0.8022
Onchocerca volvulus Cathepsin F homolog 0.0187 0.0281 0.2051
Loa Loa (eye worm) hypothetical protein 0.0158 0.0219 0.0317
Echinococcus granulosus calpain A 0.0271 0.0463 0.0457
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0812 0.1633 0.3886
Schistosoma mansoni hypothetical protein 0.0165 0.0234 0.0269
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0494 0.0945 0.1106
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0033 0.0174
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0767 0.1537 0.9435
Echinococcus multilocularis cyclins 0.0301 0.0528 0.0522
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0147 0.0194 0.293
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0017 0.0011
Schistosoma mansoni cyclin G 0.0073 0.0033 0.0033
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0102 0.0096 0.014
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0114 0.0123 0.0118
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0061 0.0009 0.0003
Brugia malayi G protein-coupled receptor 0.0494 0.0945 0.1371
Echinococcus multilocularis somatostatin receptor 0.0494 0.0945 0.094
Echinococcus multilocularis dro:myosuppressin receptor 0.0494 0.0945 0.094
Onchocerca volvulus 0.0494 0.0945 0.6898
Brugia malayi hypothetical protein 0.0081 0.0051 0.0074
Mycobacterium ulcerans zinc metalloprotease 0.0312 0.0551 0.6967
Echinococcus multilocularis transfer RNA-Lys 0.0071 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0061 0.0009 0.0013
Trypanosoma cruzi cysteine proteinase, putative 0.0099 0.0091 0.053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0187 0.0281 0.0657
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0114 0.0123 0.0118
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0494 0.0945 0.094
Brugia malayi hypothetical protein 0.0494 0.0945 0.1371
Entamoeba histolytica hypothetical protein 0.0081 0.0051 0.0434
Echinococcus granulosus rhodopsin orphan GPCR 0.0494 0.0945 0.094
Leishmania major trypanothione synthetase, putative 0.0066 0.0019 0.0087
Loa Loa (eye worm) hypothetical protein 0.007 0.0027 0.0039
Loa Loa (eye worm) hypothetical protein 0.0133 0.0163 0.0237
Trichomonas vaginalis cyclin D, putative 0.0301 0.0528 0.1246
Loa Loa (eye worm) hypothetical protein 0.0171 0.0247 0.0358
Loa Loa (eye worm) latrophilin receptor protein 2 0.0061 0.0009 0.0013
Loa Loa (eye worm) ctsf protein 0.0187 0.0281 0.0408
Leishmania major ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C12, putative 0.0111 0.0116 0.0681
Leishmania major hypothetical protein, unknown function 0.0649 0.128 0.7855
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.0281 0.0657
Brugia malayi endoprotease bli-4 precursor 0.3244 0.6895 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0099 0.0091 0.0526
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0215 0.0341 0.08
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0033 0.0066
Loa Loa (eye worm) hypothetical protein 0.0271 0.0463 0.0671
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0152 0.0348
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0077 0.0042 0.0043
Loa Loa (eye worm) hypothetical protein 0.0395 0.0731 0.1061
Schistosoma mansoni hypothetical protein 0.0081 0.0052 0.0055
Echinococcus multilocularis Cyclin L1 0.0073 0.0033 0.0028
Brugia malayi Cyclin, N-terminal domain containing protein 0.0073 0.0033 0.0048
Trypanosoma cruzi Cysteine peptidase, Clan CF, family C15 0.0422 0.079 0.4837
Onchocerca volvulus Putative endochitinase 0.0307 0.0541 0.3948
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0326 0.0581 0.3548
Loa Loa (eye worm) hypothetical protein 0.0565 0.1099 0.1595
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0147 0.0194 0.0281
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0257 0.0432 0.2627
Brugia malayi hypoxia-induced factor 1 0.0297 0.0519 0.0752
Leishmania major calpain protease-like protein 0.0246 0.0408 0.2482
Onchocerca volvulus 0.0077 0.0042 0.0306
Entamoeba histolytica cysteine proteinase, putative 0.0099 0.0091 0.0802
Loa Loa (eye worm) hypothetical protein 0.0691 0.1371 0.1988
Loa Loa (eye worm) hypothetical protein 0.0105 0.0104 0.0151
Echinococcus multilocularis cysteine protease atg4b 0.0081 0.0051 0.0045
Trypanosoma brucei Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0071 0.0031 0.0153
Toxoplasma gondii subtilisin SUB11 0.0147 0.0194 0.2726
Trypanosoma brucei cyclin 9 0.0073 0.0033 0.017
Loa Loa (eye worm) peptidase family M13 containing protein 0.023 0.0375 0.0543
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0076 0.004 0.0041
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.3809 0.8118 0.9543
Loa Loa (eye worm) hypothetical protein 0.006 0.0006 0.0008
Plasmodium vivax vivapain-3 0.0099 0.0091 0.1211
Echinococcus granulosus cathepsin L cysteine protease 0.0099 0.0091 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.0281 0.0657
Echinococcus granulosus Niemann Pick C1 protein 0.0171 0.0247 0.0241
Echinococcus multilocularis endothelin converting enzyme 1 0.0312 0.0551 0.0545
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0812 0.1633 0.3886
Schistosoma mansoni endothelin-converting enzyme-related 0.0076 0.004 0.0041
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0307 0.054 0.3295
Schistosoma mansoni adenoreceptor 0.0494 0.0945 0.1106
Echinococcus multilocularis cathepsin b 0.01 0.0093 0.0087
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0187 0.0281 0.0408
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0042 0.0043
Trichomonas vaginalis cyclins, putative 0.0565 0.1099 0.2612
Trypanosoma cruzi mitotic cyclin, putative 0.0073 0.0033 0.0174
Echinococcus multilocularis epidermal growth factor receptor 0.0081 0.0051 0.0045
Loa Loa (eye worm) hypothetical protein 0.0691 0.1371 0.1988
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0081 0.0051 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.0194 0.0449
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0195 0.0299 0.07
Schistosoma mansoni Cyclin fold protein 0.0073 0.0033 0.0033
Brugia malayi bHLH-PAS transcription factor 0.0071 0.003 0.0043
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0494 0.0945 0.094
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0386 0.0712 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0494 0.0945 0.094
Brugia malayi Calcitonin receptor-like protein seb-1 0.0194 0.0296 0.043
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0686 0.136 0.1355
Entamoeba histolytica hypothetical protein 0.0061 0.0007 0.0035
Plasmodium vivax GPI-anchor transamidase, putative 0.006 0.0006 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C51, putative 0.0307 0.054 0.3292
Loa Loa (eye worm) hypothetical protein 0.023 0.0375 0.0543
Loa Loa (eye worm) neuropeptide F receptor 0.0494 0.0945 0.1371
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0097 0.0086 0.0499
Echinococcus multilocularis protoporphyrinogen oxidase 0.0105 0.0104 0.0098
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Echinococcus granulosus transmembrane protease serine 3 0.0077 0.0042 0.0036
Loa Loa (eye worm) aminopeptidase N 0.0114 0.0123 0.0179
Loa Loa (eye worm) microfilarial chitinase 0.0262 0.0443 0.0643
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.081 0.1628 1
Entamoeba histolytica cysteine protease, putative 0.0099 0.0091 0.0802
Brugia malayi Tachykinin-like peptides receptor 99D 0.0972 0.1979 0.287
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.0194 0.0449
Toxoplasma gondii subtilisin SUB9 0.0147 0.0194 0.2726
Loa Loa (eye worm) hypothetical protein 0.0165 0.0234 0.034
Schistosoma mansoni cyclin k 0.0073 0.0033 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0328 0.0586 0.358
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0081 0.0051 0.0053
Mycobacterium leprae Possible secreted protease 0.0147 0.0194 0.2014
Echinococcus multilocularis regulator of G protein signaling 7 0.0081 0.0051 0.0045
Echinococcus granulosus calpain 0.0271 0.0463 0.0457
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0494 0.0945 0.1371
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0061 0.0009 0.0003
Plasmodium falciparum subtilisin-like protease 3 0.0147 0.0194 0.2666
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0171 0.0247 0.0284
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0063 0.0013 0.0049
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0079 0.0046 0.0097
Plasmodium vivax hypothetical protein, conserved 0.0063 0.0013 0.0105
Toxoplasma gondii hypothetical protein 0.0073 0.0033 0.0468
Toxoplasma gondii hypothetical protein 0.0228 0.037 0.5205
Echinococcus granulosus inhibitor of apoptosis protein 0.016 0.0222 0.0216
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0471 0.0896 0.5488
Leishmania major trypanothione synthetase, putative 0.0066 0.0019 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.0281 0.0657
Entamoeba histolytica cysteine protease, putative 0.0099 0.0091 0.0802
Leishmania major trypanothione synthetase-like protein 0.0066 0.0019 0.0087
Loa Loa (eye worm) hypothetical protein 0.01 0.0093 0.0135
Schistosoma mansoni cathepsin D (A01 family) 0.0567 0.1102 0.129
Brugia malayi endochitinase 0.0307 0.0541 0.0785
Echinococcus multilocularis rhodopsin orphan GPCR 0.0494 0.0945 0.094
Giardia lamblia Cyclin A 0.0301 0.0528 0.2147
Leishmania major small myristoylated protein-3, putative 0.0357 0.0648 0.3961
Trypanosoma brucei inhibitor of cysteine peptidase 0.023 0.0373 0.2265
Echinococcus multilocularis sterol regulatory element binding protein 0.0171 0.0247 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0033 0.0066
Loa Loa (eye worm) fibroinase 0.0187 0.0281 0.0408
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0036 0.0031
Echinococcus multilocularis neuropeptide Y receptor 0.0494 0.0945 0.094
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase isozyme 0.0122 0.0141 0.0135
Echinococcus multilocularis tissue type plasminogen activator 0.0158 0.0219 0.0213
Schistosoma mansoni calpain-7 (C02 family) 0.0345 0.0624 0.0727
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.004 0.0083
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0147 0.0194 0.0188
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0494 0.0945 0.1106
Trypanosoma brucei otubain cysteine peptidase, Clan CA, family C65, putative 0.0084 0.0059 0.0325
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0076 0.0042 0.0225
Echinococcus granulosus g-protein coupled receptor 0.0494 0.0945 0.094
Leishmania major receptor-type adenylate cyclase a-like protein 0.0263 0.0446 0.2715
Echinococcus multilocularis cyclin B3 1 0.0301 0.0528 0.0522
Entamoeba histolytica cysteine proteinase 2 0.0099 0.0091 0.0802
Schistosoma mansoni hypothetical protein 0.0158 0.0219 0.0251
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Schistosoma mansoni cyclin B 0.0565 0.1099 0.1287
Brugia malayi Cathepsin L-like precursor 0.0127 0.0152 0.022
Entamoeba histolytica cysteine protease, putative 0.0099 0.0091 0.0802
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0494 0.0945 0.1106
Loa Loa (eye worm) hypothetical protein 0.006 0.0006 0.0009
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0079 0.0046 0.0253
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 12 0.0071 0.0031 0.0025
Brugia malayi hypothetical protein 0.0494 0.0945 0.1371
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0114 0.0123 0.0118
Echinococcus granulosus Regulator of G protein signaling 20 0.0081 0.0051 0.0045
Loa Loa (eye worm) hypothetical protein 0.0073 0.0033 0.0048
Brugia malayi cyclin fold protein 1 variant b 0.0073 0.0033 0.0048
Trichomonas vaginalis cyclin B, putative 0.0565 0.1099 0.2612
Loa Loa (eye worm) hypothetical protein 0.0215 0.0341 0.0494
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0042 0.0043
Onchocerca volvulus Putative endochitinase 0.0307 0.0541 0.3948
Schistosoma mansoni cathepsin F (C01 family) 0.0187 0.0281 0.0324
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0079 0.0046 0.0249
Echinococcus granulosus neuropeptide receptor A26 0.0959 0.195 0.1946
Trypanosoma brucei calpain, putative 0.0215 0.0341 0.2064
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0595 0.1164 0.7138
Trichomonas vaginalis cyclins, putative 0.0565 0.1099 0.2612
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0187 0.0281 0.0657
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.0091 0.0204
Onchocerca volvulus 0.0494 0.0945 0.6898
Trypanosoma brucei calpain-like protein, putative 0.029 0.0504 0.307
Echinococcus granulosus cyclins 0.0301 0.0528 0.0522
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0114 0.0123 0.0118
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0494 0.0945 0.094
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0129 0.0156 0.0928
Loa Loa (eye worm) papain family cysteine protease containing protein 0.006 0.0006 0.0008
Giardia lamblia G2/mitotic-specific cyclin B 0.0565 0.1099 0.45
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0565 0.1099 0.6742
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0079 0.0046 0.0393
Trypanosoma cruzi trypanothione synthetase 0.0066 0.0019 0.0087
Loa Loa (eye worm) hypothetical protein 0.0215 0.0341 0.0494
Trichomonas vaginalis cyclin D, putative 0.0073 0.0033 0.0066
Brugia malayi Cathepsin L-like precursor 0.0187 0.0281 0.0408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.0281 0.0657
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Onchocerca volvulus 0.0494 0.0945 0.6898
Plasmodium falciparum cyclin 1 0.0073 0.0033 0.039
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0042 0.0043
Echinococcus multilocularis neuropeptide s receptor 0.0959 0.195 0.1946
Brugia malayi hypothetical protein 0.0081 0.0051 0.0074
Echinococcus multilocularis serotonin receptor 0.0494 0.0945 0.094
Echinococcus multilocularis cyclins 0.0301 0.0528 0.0522
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.01 0.0093 0.0541
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0033 0.0392
Trypanosoma brucei calpain, putative 0.0471 0.0896 0.5488
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.0281 0.0657
Toxoplasma gondii subtilisin SUB8 0.0147 0.0194 0.2726
Echinococcus granulosus rhodopsin orphan GPCR 0.0494 0.0945 0.094
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0619 0.1215 0.7454
Echinococcus multilocularis membrane bound transcription factor site 1 0.0147 0.0194 0.0188
Trichomonas vaginalis calpain, putative 0.0215 0.0341 0.08
Echinococcus multilocularis ubiquitin specific peptidase (c family) ubiquitin terminal hydrolase 0.0129 0.0156 0.015
Plasmodium vivax aspartyl proteinase, putative 0.0192 0.0292 0.4055
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0097 0.0086 0.008
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 14 0.007 0.0027 0.0298
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0665 0.1315 0.3126
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.006 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0074 0.0036 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0326 0.0581 0.3548
Loa Loa (eye worm) hypothetical protein 0.023 0.0375 0.0543
Loa Loa (eye worm) calpain 0.0302 0.053 0.0769
Loa Loa (eye worm) cuticular endochitinase 0.0307 0.0541 0.0785
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0076 0.004 0.0035
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0215 0.0341 0.08
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Schistosoma mansoni neuropeptide receptor 0.0494 0.0945 0.1106
Loa Loa (eye worm) hypothetical protein 0.0077 0.0042 0.0061
Brugia malayi celfurPC protein 0.2579 0.5456 0.7913
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0081 0.0051 0.0279
Loa Loa (eye worm) G-protein coupled receptor 0.0494 0.0945 0.1371
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0194 0.0296 0.043
Onchocerca volvulus Putative endochitinase 0.0307 0.0541 0.3948
Leishmania major hypothetical protein, conserved 0.0426 0.0798 0.4883
Schistosoma mansoni g1/s-specific cyclin C 0.0073 0.0033 0.0033
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0147 0.0194 0.0188
Brugia malayi Peptidase family C54 containing protein 0.0081 0.0051 0.0073
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0042 0.0225
Schistosoma mansoni alpha-1 adrenergic receptor 0.0494 0.0945 0.1106
Loa Loa (eye worm) integrin alpha pat-2 0.1187 0.2445 0.3546
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.004 0.0083
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0079 0.0046 0.022
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0395 0.073 0.4466
Loa Loa (eye worm) hypothetical protein 0.3244 0.6895 1
Echinococcus multilocularis neuroendocrine convertase 2 0.2061 0.4335 0.4332
Echinococcus multilocularis neuropeptide FF receptor 2 0.0972 0.1979 0.1974
Entamoeba histolytica cysteine protease, putative 0.0187 0.0281 0.2535
Trypanosoma brucei SUMO1/Ulp2, putative 0.0177 0.0259 0.1558
Schistosoma mansoni cyclin G2 0.0073 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Loa Loa (eye worm) RGS-3 protein 0.0081 0.0051 0.0074
Brugia malayi peptidase family M13 containing protein 0.0076 0.004 0.0059
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0767 0.1537 0.9435
Entamoeba histolytica peptidase, C54 family 0.0081 0.0051 0.0432
Loa Loa (eye worm) hypothetical protein 0.0154 0.021 0.0305
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0109 0.0113 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0051 0.0107
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0307 0.054 0.3295
Echinococcus granulosus Peptidase C54 0.0081 0.0051 0.0045
Echinococcus granulosus calpain 7 C02 family 0.0302 0.053 0.0525
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0157 0.0216 0.0248
Trypanosoma cruzi aminopeptidase, putative 0.0114 0.0123 0.0729
Loa Loa (eye worm) hypothetical protein 0.0583 0.1137 0.1648
Schistosoma mansoni tyrosine kinase 0.008 0.0049 0.0051
Echinococcus multilocularis cyclins 0.0301 0.0528 0.0522
Toxoplasma gondii subtilisin SUB7 0.0147 0.0194 0.2726
Schistosoma mansoni hypothetical protein 0.0061 0.0009 0.0004
Trypanosoma cruzi major cysteine proteinase, putative 0.0178 0.0262 0.1582
Echinococcus multilocularis sex peptide receptor 0.0494 0.0945 0.094
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.081 0.1628 1
Leishmania major D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative 0.0307 0.054 0.3295
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0494 0.0945 0.094
Trichomonas vaginalis ubiquitin specific protease, putative 0.0062 0.001 0.0011
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0071 0.0031 0.0153
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0129 0.0156 0.0928
Onchocerca volvulus 0.0494 0.0945 0.6898
Loa Loa (eye worm) hypothetical protein 0.0081 0.0051 0.0073
Echinococcus multilocularis g-protein coupled receptor 0.0494 0.0945 0.094
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1995 0.4193 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0494 0.0945 0.094
Echinococcus granulosus neuroendocrine convertase 2 0.2061 0.4335 0.4332
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0076 0.004 0.0041
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0494 0.0945 0.094
Echinococcus granulosus epidermal growth factor receptor 0.0507 0.0973 0.0968
Echinococcus granulosus cathepsin l1 0.0127 0.0152 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.0281 0.0657
Onchocerca volvulus 0.0494 0.0945 0.6898
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0187 0.0281 0.0275
Entamoeba histolytica calpain family cysteine protease, putative 0.0282 0.0487 0.441
Onchocerca volvulus 0.0187 0.0281 0.2051
Leishmania major chitinase 0.0307 0.0541 0.3302
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0081 0.0051 0.0045
Schistosoma mansoni hypothetical protein 0.0081 0.0052 0.0055
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0147 0.0194 0.0222
Schistosoma mansoni opsin-like receptor 0.0494 0.0945 0.1106
Trypanosoma cruzi cruzipain precursor, putative 0.006 0.0006 0.0003
Brugia malayi Peptidase family M13 containing protein 0.0312 0.0551 0.0799
Echinococcus multilocularis protein patched 0.0171 0.0247 0.0241
Brugia malayi Peptidase family M1 containing protein 0.0114 0.0123 0.0179
Trypanosoma cruzi cysteine protease, putative 0.0099 0.0091 0.053
Loa Loa (eye worm) hypothetical protein 0.0076 0.0042 0.006
Trypanosoma brucei mitotic cyclin 0.0073 0.0033 0.017
Schistosoma mansoni Mername-AA248 (C02 family) 0.0271 0.0463 0.0538
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Echinococcus granulosus dro:myosuppressin receptor 0.0494 0.0945 0.094
Schistosoma mansoni regulator of G protein signaling 0.0081 0.0051 0.0053
Brugia malayi G-protein coupled receptor 0.0494 0.0945 0.1371
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0081 0.0051 0.0074
Onchocerca volvulus 0.0494 0.0945 0.6898
Loa Loa (eye worm) hypothetical protein 0.0274 0.0469 0.068
Trypanosoma cruzi UDP-galactopyranose mutase 0.0105 0.0104 0.0609
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0494 0.0945 0.094
Loa Loa (eye worm) hypothetical protein 0.0312 0.0551 0.0799
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0116 0.0126 0.0183
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.01 0.0093 0.0541
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0494 0.0945 0.094
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0076 0.0042 0.0036
Loa Loa (eye worm) hypothetical protein 0.0264 0.0448 0.065
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Echinococcus granulosus cyclin y 0.0073 0.0033 0.0028
Entamoeba histolytica cysteine proteinase, putative 0.0187 0.0281 0.2535
Schistosoma mansoni neuropeptide receptor 0.126 0.2603 0.3055
Brugia malayi AKH receptor 0.0494 0.0945 0.1371
Trichomonas vaginalis cyclin B3, putative 0.0073 0.0033 0.0066
Entamoeba histolytica cysteine protease, putative 0.0099 0.0091 0.0802
Giardia lamblia Hypothetical protein 0.0073 0.0033 0.0113
Schistosoma mansoni calpain-7 (C02 family) 0.0345 0.0624 0.0727
Brugia malayi cathepsin F-like cysteine proteinase 0.006 0.0006 0.0008
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0076 0.004 0.0041
Brugia malayi endochitinase 0.0307 0.0541 0.0785
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0105 0.0104 0.0116
Toxoplasma gondii cathepsin CPC2 0.0386 0.0712 1
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0207 0.0324 0.1966
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0207 0.0324 0.1963
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.007 0.0027 0.0377
Onchocerca volvulus 0.0614 0.1205 0.879
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0147 0.0194 0.2014
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0263 0.0446 0.2712
Echinococcus multilocularis rhodopsin orphan GPCR 0.0494 0.0945 0.094
Brugia malayi Kelch motif family protein 0.0395 0.0731 0.1061
Schistosoma mansoni serine/threonine protein kinase 0.0164 0.0232 0.0266
Schistosoma mansoni neprilysin-2 (M13 family) 0.0157 0.0216 0.0248
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0079 0.0046 0.004
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0114 0.0123 0.0118
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0074 0.0036 0.0192
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0259 0.0436 0.2653
Echinococcus granulosus dnaJ subfamily B 0.2823 0.5984 0.5982
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0432 0.2624
Echinococcus granulosus regulator of G protein signaling 7 0.0081 0.0051 0.0045
Echinococcus multilocularis neuropeptides capa receptor 0.0494 0.0945 0.094
Onchocerca volvulus 0.0147 0.0194 0.1415
Schistosoma mansoni amine GPCR 0.0494 0.0945 0.1106
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.3244 0.6895 0.8105
Loa Loa (eye worm) hypothetical protein 0.023 0.0375 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.0194 0.0449
Entamoeba histolytica cysteine protease, putative 0.0099 0.0091 0.0802
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0081 0.0052 0.0055
Brugia malayi hypothetical protein 0.0494 0.0945 0.1371
Leishmania major hypothetical protein, conserved,calpain-like cysteine peptidase, Clan CA, family C2 0.0552 0.107 0.6559
Echinococcus multilocularis sortilin 0.0282 0.0486 0.048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0494 0.0945 0.094
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Brugia malayi latrophilin 2 splice variant baaae 0.0133 0.0163 0.0237
Toxoplasma gondii peptidase family M13 protein 0.0312 0.0551 0.7738
Echinococcus multilocularis cyclin A3 4 0.0073 0.0033 0.0028
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0228 0.037 0.2246
Plasmodium falciparum protoporphyrinogen oxidase 0.0105 0.0104 0.1392
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.081 0.1628 1
Echinococcus granulosus cyclin b3 0.0301 0.0528 0.0522
Schistosoma mansoni hypothetical protein 0.0081 0.0052 0.0055
Onchocerca volvulus 0.0494 0.0945 0.6898
Echinococcus granulosus axis inhibition protein axin 0.0081 0.0051 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0665 0.1315 0.3126
Loa Loa (eye worm) hypothetical protein 0.0189 0.0285 0.0414
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0528 0.1018 0.6243
Onchocerca volvulus Cathepsin L homolog 0.0187 0.0281 0.2051
Mycobacterium ulcerans chitinase/cellulase 0.0262 0.0443 0.5529
Brugia malayi Latrophilin receptor protein 2 0.0061 0.0009 0.0013
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.016 0.0222 0.0321
Trichomonas vaginalis hypothetical protein 0.0665 0.1315 0.3126
Loa Loa (eye worm) hypothetical protein 0.0081 0.0051 0.0074
Entamoeba histolytica hypothetical protein 0.0081 0.0051 0.0434
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0338 0.0608 0.3712
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0273 0.0467 0.2848
Loa Loa (eye worm) hypothetical protein 0.0074 0.0036 0.0053
Brugia malayi Papain family cysteine protease containing protein 0.0099 0.0091 0.0132
Trichomonas vaginalis cyclin A, putative 0.0565 0.1099 0.2612
Loa Loa (eye worm) hypothetical protein 0.0077 0.0042 0.0061
Echinococcus granulosus G protein coupled receptor kinase 1 0.0084 0.0057 0.0052
Schistosoma mansoni furin-1 (S08 family) 0.1396 0.2896 0.3401
Plasmodium vivax hypothetical protein, conserved 0.0105 0.0104 0.1394
Trichomonas vaginalis cyclins, putative 0.0073 0.0033 0.0066
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.016 0.0222 0.0216
Schistosoma mansoni integrin beta subunit 0.1508 0.3139 0.3686
Schistosoma mansoni regulator of G protein signaling 0.0081 0.0051 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0247 0.0576
Schistosoma mansoni biogenic amine (5HT) receptor 0.0494 0.0945 0.1106
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0417 0.0777 0.4758
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0114 0.0123 0.0118
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0417 0.0777 1
Loa Loa (eye worm) cysteine protease 0.0187 0.0281 0.0408
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0147 0.0194 0.293
Trypanosoma brucei calpain-like protein, putative 0.0271 0.0463 0.2818
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0312 0.0551 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0494 0.0945 0.094
Plasmodium falciparum subtilisin-like protease 1 0.0147 0.0194 0.2666
Entamoeba histolytica cysteine protease, putative 0.0099 0.0091 0.0802
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.081 0.1628 1
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0081 0.0051 0.0107
Schistosoma mansoni autophagin-1 (C54 family) 0.0081 0.0051 0.0053
Echinococcus granulosus g protein coupled receptor 0.0494 0.0945 0.094
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0494 0.0945 0.1371
Onchocerca volvulus 0.0494 0.0945 0.6898
Trypanosoma cruzi cruzipain precursor, putative 0.0326 0.0581 0.355
Trypanosoma cruzi cyclin, putative 0.0565 0.1099 0.6742
Schistosoma mansoni serine/threonine protein kinase 0.0473 0.0899 0.1051
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Schistosoma mansoni glutamate receptor NMDA 0.0259 0.0436 0.0506
Schistosoma mansoni cathepsin F (C01 family) 0.0127 0.0152 0.0172
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.1995 0.4193 0.4189
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0147 0.0194 0.293
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0494 0.0945 0.1106
Brugia malayi hypothetical protein 0.0073 0.0033 0.0048
Loa Loa (eye worm) calpain family protein 1 0.0271 0.0463 0.0671
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.04 0.0741 0.4534
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0099 0.0091 0.053
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0116 0.0126 0.012
Trypanosoma brucei Calpain-like protein CALP1.3 0.0478 0.091 0.5575
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0076 0.0042 0.0042
Schistosoma mansoni calpain-2 (C02 family) 0.0215 0.0341 0.0394
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0301 0.0528 0.0522
Entamoeba histolytica cysteine proteinase, putative 0.0099 0.0091 0.0802
Echinococcus granulosus calpain 5 0.0271 0.0463 0.0457
Echinococcus granulosus sterol regulatory element binding protein 0.0171 0.0247 0.0241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0326 0.0581 0.3548
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0081 0.0051 0.0045
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase BAP1 0.0061 0.0007 0.0001
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0192 0.0292 0.4102
Schistosoma mansoni hypothetical protein 0.0069 0.0026 0.0023
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0691 0.1371 0.1606
Echinococcus granulosus rhodopsin orphan GPCR 0.0494 0.0945 0.094
Echinococcus multilocularis nmda type glutamate receptor 0.0109 0.0113 0.0107
Echinococcus multilocularis protein dispatched 1 0.0171 0.0247 0.0241
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0254 0.0426 0.2595
Trypanosoma cruzi trypanothione synthetase, putative 0.0066 0.0019 0.0087
Loa Loa (eye worm) hypothetical protein 0.016 0.0222 0.0321
Brugia malayi Papain family cysteine protease containing protein 0.0187 0.0281 0.0408
Brugia malayi Trypsin family protein 0.0077 0.0042 0.0061
Brugia malayi calpain 7 0.0302 0.053 0.0769
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0417 0.0777 0.1127
Trypanosoma cruzi Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0228 0.037 0.2246
Brugia malayi hypothetical protein 0.0494 0.0945 0.1371
Toxoplasma gondii kringle domain-containing protein 0.0158 0.0219 0.3073
Trypanosoma cruzi cysteine peptidase, putative 0.0099 0.0091 0.053
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0456 0.0863 0.5288
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0017 0.007
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0129 0.0156 0.0358
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0494 0.0945 0.094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.0281 0.0657
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 14 0.007 0.0027 0.0021
Loa Loa (eye worm) hypothetical protein 0.0127 0.0152 0.022
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0271 0.0463 0.0538
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0271 0.0463 0.0457
Loa Loa (eye worm) hypothetical protein 0.023 0.0375 0.0543
Leishmania major hypothetical protein, conserved 0.0328 0.0586 0.358
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0177 0.0259 0.1561
Onchocerca volvulus 0.006 0.0006 0.0043
Echinococcus granulosus integrin alpha ps 0.0165 0.0234 0.0229
Trichomonas vaginalis Clan CA, family C12, ubiquitin hydrolase-like cysteine peptidase 0.0122 0.0141 0.0323
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0257 0.0432 0.2624
Echinococcus multilocularis cathepsin b 0.01 0.0093 0.0087
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0114 0.0123 0.0118
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0061 0.0009 0.0013
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.007 0.0027 0.0086
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0147 0.0194 0.2197
Trichomonas vaginalis conserved hypothetical protein 0.0665 0.1315 0.3126
Brugia malayi Trypsin family protein 0.0077 0.0042 0.0061
Echinococcus granulosus cathepsin L 0.0099 0.0091 0.0085
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0076 0.004 0.0058
Plasmodium vivax sortilin, putative 0.0282 0.0486 0.6803
Echinococcus granulosus cyclin 0.0073 0.0033 0.0028
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.04 0.0741 0.4534
Onchocerca volvulus 0.0388 0.0716 0.5226
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0147 0.0194 0.293
Schistosoma mansoni calpain C (C02 family) 0.0271 0.0463 0.0538
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0494 0.0945 0.1106
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0051 0.0107
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0168 0.0239 0.3822
Echinococcus granulosus serotonin receptor 0.0494 0.0945 0.094
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0051 0.0107
Loa Loa (eye worm) hypothetical protein 0.0562 0.1093 0.1585
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0084 0.0057 0.0052
Loa Loa (eye worm) PXA domain-containing protein 0.0081 0.0051 0.0074
Echinococcus granulosus expressed protein 0.1164 0.2394 0.239
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0063 0.0013 0.0049
Echinococcus multilocularis ubiquitin specific peptidase 42 (C19 family) 0.0063 0.0013 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0357 0.0648 0.3958
Echinococcus granulosus cyclin A3 4 0.0073 0.0033 0.0028
Trichomonas vaginalis calpain, putative 0.0215 0.0341 0.08
Entamoeba histolytica cyclin, putative 0.0565 0.1099 1
Echinococcus granulosus regulator of G protein signaling 7 0.0081 0.0051 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0326 0.0581 0.3548
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0073 0.0033 0.039
Brugia malayi Cyclin, N-terminal domain containing protein 0.0565 0.1099 0.1595
Entamoeba histolytica cysteine protease, putative 0.0099 0.0091 0.0802
Entamoeba histolytica peptidase, C54 family 0.0192 0.0292 0.2632
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.01 0.0093 0.0541
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0494 0.0945 0.094
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0494 0.0945 0.1371
Trypanosoma cruzi otubain cysteine peptidase, Clan CA, family C65, putative 0.0084 0.0059 0.0329
Trypanosoma cruzi UDP-galactopyranose mutase 0.0105 0.0104 0.0609
Trypanosoma brucei conserved protein 0.0211 0.0333 0.2018
Brugia malayi EGF-like domain containing protein 0.006 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0312 0.0551 0.0799
Entamoeba histolytica cysteine protease, putative 0.0099 0.0091 0.0802
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0076 0.004 0.0058
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0077 0.0042 0.0043
Schistosoma mansoni amine oxidase 0.0105 0.0104 0.0116
Brugia malayi Serotonin receptor 0.0494 0.0945 0.1371
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0042 0.0043
Plasmodium falciparum plasmepsin VI 0.0192 0.0292 0.4054
Schistosoma mansoni otubain-1 (C65 family) 0.0084 0.0059 0.0062
Loa Loa (eye worm) hypothetical protein 0.0322 0.0573 0.0831
Trypanosoma cruzi cysteine peptidase, putative 0.0187 0.0281 0.17
Brugia malayi RE15519p 0.0494 0.0945 0.1371
Schistosoma mansoni hypothetical protein 0.0494 0.0945 0.1106
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0063 0.0013 0.0103
Plasmodium falciparum deubiquinating/deneddylating enzyme 0.0111 0.0116 0.1556
Schistosoma mansoni neuropeptide receptor 0.0494 0.0945 0.1106
Trichomonas vaginalis cyclins, putative 0.0073 0.0033 0.0066
Entamoeba histolytica hypothetical protein 0.0081 0.0051 0.0434
Echinococcus granulosus cyclin y 0.0073 0.0033 0.0028
Trypanosoma cruzi cyclin, putative 0.0565 0.1099 0.6742
Entamoeba histolytica cysteine proteinase, putative 0.0099 0.0091 0.0802
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0228 0.037 0.2243
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0171 0.0247 0.0358
Loa Loa (eye worm) cyclin domain-containing protein 0.0073 0.0033 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.0281 0.0657
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.007 0.0027 0.0133
Echinococcus multilocularis cyclin b3 0.0301 0.0528 0.0522
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0064 0.0015 0.0022
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 46 0.0071 0.0031 0.0045
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0073 0.0033 0.039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0187 0.0281 0.0657
Schistosoma mansoni family C12 unassigned peptidase (C12 family) 0.0122 0.0141 0.0159
Loa Loa (eye worm) hypothetical protein 0.0236 0.0386 0.056
Loa Loa (eye worm) TK/EGFR protein kinase 0.0507 0.0973 0.1411
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0076 0.0042 0.0351
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0129 0.0156 0.0928
Trichomonas vaginalis cyclins, putative 0.0337 0.0605 0.1432
Mycobacterium ulcerans chitinase/cellulase 0.0262 0.0443 0.5529
Echinococcus granulosus fmrfamide receptor 0.0494 0.0945 0.094
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0042 0.0086
Loa Loa (eye worm) chitinase I 0.0307 0.0541 0.0785
Plasmodium falciparum plasmepsin II 0.0192 0.0292 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.0281 0.0657
Echinococcus granulosus ubiquitin specific peptidase c family 0.0129 0.0156 0.015
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0812 0.1633 0.3886
Schistosoma mansoni biogenic amine (5HT) receptor 0.0494 0.0945 0.1106
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0187 0.0281 0.0657
Trichomonas vaginalis conserved hypothetical protein 0.0665 0.1315 0.3126
Brugia malayi Cyclin, N-terminal domain containing protein 0.0073 0.0033 0.0048
Schistosoma mansoni histamine h1 receptor 0.0494 0.0945 0.1106
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0033 0.0066
Echinococcus multilocularis allatostatin A receptor 0.0494 0.0945 0.094
Brugia malayi regulator of G-protein signaling rgs-7 0.0081 0.0051 0.0074
Loa Loa (eye worm) hypothetical protein 0.0081 0.0051 0.0074
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0192 0.0292 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.0194 0.0449
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0073 0.0033 0.0028
Schistosoma mansoni aryl hydrocarbon receptor 0.0096 0.0084 0.0092
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0494 0.0945 0.6898
Brugia malayi Myb-like DNA-binding domain containing protein 0.0189 0.0285 0.0414
Trypanosoma cruzi cysteine peptidase, putative 0.0326 0.0581 0.355
Brugia malayi G-protein coupled receptor 0.0494 0.0945 0.1371
Mycobacterium ulcerans epoxide hydrolase EphA 0.0168 0.0239 0.2798
Brugia malayi Regulator of G protein signaling domain containing protein 0.0081 0.0051 0.0074
Onchocerca volvulus 0.0187 0.0281 0.2051
Plasmodium falciparum plasmepsin IV 0.0192 0.0292 0.4054
Loa Loa (eye worm) hypothetical protein 0.0312 0.0551 0.0799
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0153 0.0208 0.1247
Plasmodium falciparum cysteine proteinase falcipain 1 0.0099 0.0091 0.1209
Brugia malayi calpain family protein 1 0.0271 0.0463 0.0671
Trypanosoma brucei CHAP domain containing protein, putative 0.0066 0.0019 0.0083
Entamoeba histolytica cysteine proteinase, putative 0.0187 0.0281 0.2535
Echinococcus granulosus sortilin 0.0282 0.0486 0.048
Brugia malayi Cathepsin L-like precursor 0.0187 0.0281 0.0408
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.01 0.0093 0.0103
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0228 0.037 0.2246
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Schistosoma mansoni opsin-like receptor 0.0494 0.0945 0.1106
Trypanosoma brucei cysteine peptidase, putative 0.0558 0.1084 0.6646
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0071 0.0031 0.0059
Echinococcus multilocularis regulator of G protein signaling 0.0081 0.0051 0.0045
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0076 0.0042 0.0042
Brugia malayi hypothetical protein 0.0494 0.0945 0.1371
Schistosoma mansoni neuropeptide F-like receptor 0.0494 0.0945 0.1106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0326 0.0581 0.3548
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0301 0.0528 0.0522
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0494 0.0945 0.094
Schistosoma mansoni ubiquitin-specific peptidase 7 (C19 family) 0.0097 0.0086 0.0095
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0081 0.0051 0.0107
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase isozyme L3, putative 0.0122 0.0141 0.1919
Echinococcus granulosus cathepsin l cysteine peptidase 0.0187 0.0281 0.0275
Brugia malayi Peptidase family M1 containing protein 0.0388 0.0716 0.1039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0187 0.0281 0.0657
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0528 0.1018 0.6243
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Giardia lamblia Hypothetical protein 0.0301 0.0528 0.2147
Loa Loa (eye worm) hypothetical protein 0.0077 0.0042 0.0061
Trypanosoma cruzi cysteine peptidase inhibitor, putative 0.023 0.0373 0.2268
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0079 0.0046 0.5
Echinococcus multilocularis fibrillin 2 0.006 0.0006 0.0000067591
Trypanosoma brucei unspecified product 0.0263 0.0446 0.2712
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0254 0.0426 0.2595
Loa Loa (eye worm) hypothetical protein 0.0605 0.1184 0.1718
Echinococcus granulosus aminopeptidase N 0.0388 0.0716 0.0711
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0215 0.0341 0.08
Loa Loa (eye worm) hypothetical protein 0.0147 0.0194 0.0281
Echinococcus granulosus axis inhibition protein axin 0.0081 0.0051 0.0045
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0073 0.0033 0.0033
Echinococcus granulosus beta-adrenergic receptor kinase 0.0164 0.0232 0.0226
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0063 0.0013 0.0017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0357 0.0648 0.3961
Trypanosoma cruzi hypothetical protein, conserved 0.0263 0.0446 0.2715
Echinococcus multilocularis integrin alpha ps 0.0165 0.0234 0.0229
Brugia malayi G protein-coupled receptor F59B2.13 0.0494 0.0945 0.1371
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0196 0.0301 0.0436
Schistosoma mansoni amine GPCR 0.0494 0.0945 0.1106
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0077 0.0042 0.0043
Schistosoma mansoni hypothetical protein 0.0077 0.0042 0.0043
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0077 0.0042 0.0043
Echinococcus granulosus epidermal growth factor receptor 0.0081 0.0051 0.0045
Brugia malayi Dopamine receptor protein 1 0.0494 0.0945 0.1371
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Schistosoma mansoni ubiquitin-specific peptidase 42 (C19 family) 0.0063 0.0013 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0187 0.0281 0.0657
Plasmodium vivax subtilisin-like serine protease, putative 0.0147 0.0194 0.2668
Echinococcus multilocularis Furin 1 0.0812 0.1633 0.1628
Echinococcus granulosus Furin 1 0.0812 0.1633 0.1628
Schistosoma mansoni serine-type protease inhibitor 0.3988 0.8506 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0033 0.0048
Toxoplasma gondii cyclin dependent kinase binding protein 0.0073 0.0033 0.0468
Onchocerca volvulus 0.0494 0.0945 0.6898
Trypanosoma brucei cyclin 3 0.0073 0.0033 0.017
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0417 0.0777 0.4758
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0076 0.0042 0.0036
Leishmania major cathepsin L-like protease 0.0326 0.0581 0.355
Onchocerca volvulus 0.0691 0.1371 1
Entamoeba histolytica cysteine protease inhibitor 1 (EhICP1) 0.023 0.0373 0.3377
Schistosoma mansoni neuropeptide receptor 0.0494 0.0945 0.1106
Onchocerca volvulus 0.0187 0.0281 0.2051
Echinococcus multilocularis cathepsin L cysteine protease 0.0187 0.0281 0.0275
Loa Loa (eye worm) hypothetical protein 0.006 0.0006 0.0009
Echinococcus granulosus cyclin t1 0.0073 0.0033 0.0028
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase isozyme L3 0.0122 0.0141 0.1918
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0558 0.1084 0.6647
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0395 0.0731 0.1061
Entamoeba histolytica chitinase, putative 0.0307 0.0541 0.4907
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0228 0.037 0.2246
Brugia malayi follicle stimulating hormone receptor 0.0494 0.0945 0.1371
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.0281 0.0657
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0042 0.0043
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0471 0.0896 0.5489
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0102 0.0096 0.014
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0114 0.0123 0.0281
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase BAP1 0.0061 0.0007 0.0001
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-4 0.0552 0.107 0.6558
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0076 0.004 0.0035
Toxoplasma gondii aspartyl protease ASP1 0.0192 0.0292 0.4102
Echinococcus granulosus cyclin B3 1 0.0301 0.0528 0.0522
Echinococcus granulosus hypothetical protein 0.0494 0.0945 0.094
Schistosoma mansoni hypothetical protein 0.0133 0.0163 0.0185
Loa Loa (eye worm) cyclin domain-containing protein 0.0073 0.0033 0.0048
Plasmodium vivax vivapain-2 0.0187 0.0281 0.3902
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0583 0.1137 0.1648
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0812 0.1633 0.3886
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0177 0.0259 0.1561
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0192 0.0292 0.0683
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0494 0.0945 0.1106
Toxoplasma gondii subtilisin SUB2 0.0147 0.0194 0.2726
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0116 0.0126 0.0183
Echinococcus granulosus 7TM GPCR rhodopsin 0.0494 0.0945 0.094
Chlamydia trachomatis protoporphyrinogen oxidase 0.0105 0.0104 1
Entamoeba histolytica cysteine protease, putative 0.0099 0.0091 0.0802
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0017 0.0024
Echinococcus multilocularis Regulator of G protein signaling 20 0.0081 0.0051 0.0045
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0273 0.0467 0.2845
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0257 0.0432 0.2624
Trypanosoma brucei Domain of unknown function (DUF1935), putative 0.0263 0.0446 0.2712
Trypanosoma brucei trypanothione synthetase, putative 0.0066 0.0019 0.0083
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0192 0.0292 0.1766
Echinococcus multilocularis beta adrenergic receptor kinase 0.0164 0.0232 0.0226
Echinococcus multilocularis cyclin 0.0073 0.0033 0.0028
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0263 0.0446 0.2712
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0081 0.0051 0.0107
Echinococcus granulosus furin 0.3244 0.6895 0.6893
Loa Loa (eye worm) zinc metallopeptidase 4 0.0076 0.004 0.0059
Onchocerca volvulus 0.0127 0.0152 0.1106
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0228 0.037 0.2246
Brugia malayi Regulator of G protein signaling domain containing protein 0.0081 0.0051 0.0074
Echinococcus granulosus cathepsin l1 0.0187 0.0281 0.0275
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0641 0.1263 0.775
Echinococcus granulosus cyclins 0.0301 0.0528 0.0522
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.081 0.1628 1
Leishmania major mitotic cyclin, putative 0.0073 0.0033 0.0174
Loa Loa (eye worm) cyclin domain-containing protein 0.0301 0.0528 0.0765
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Leishmania major pyroglutamyl-peptidase I (C15 family) 0.0422 0.079 0.4837
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0076 0.004 0.0041
Trypanosoma brucei subtilisin peptidase 0.0147 0.0194 0.116
Schistosoma mansoni site-1 peptidase (S08 family) 0.0147 0.0194 0.0222
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0081 0.0051 0.0107
Loa Loa (eye worm) cyclin C 0.0073 0.0033 0.0048
Loa Loa (eye worm) hypothetical protein 0.0122 0.0141 0.0205
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Loa Loa (eye worm) hypothetical protein 0.0425 0.0795 0.1154
Trichomonas vaginalis cyclin B, putative 0.0565 0.1099 0.2612
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1995 0.4193 1
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0693 0.1375 0.161
Brugia malayi ubiquitin carboxyl-terminal hydrolase 46 0.0071 0.0031 0.0045
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0074 0.0036 0.0036
Entamoeba histolytica cyclin family protein 0.0301 0.0528 0.4783
Echinococcus multilocularis 0.0105 0.0104 0.0098
Giardia lamblia Cathepsin B precursor 0.01 0.0093 0.0359
Brugia malayi GnHR receptor homolog 0.0494 0.0945 0.1371
Leishmania major ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C12, putative 0.0122 0.0141 0.0838
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.4679 1 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0357 0.0648 0.3961
Plasmodium vivax plasmepsin IV, putative 0.0192 0.0292 0.4055
Echinococcus multilocularis orexin receptor type 2 0.0494 0.0945 0.094
Echinococcus multilocularis dnaJ subfamily B 0.2823 0.5984 0.5982
Echinococcus multilocularis regulator of G protein signaling 3 0.0081 0.0051 0.0045
Onchocerca volvulus 0.016 0.0222 0.1616
Echinococcus granulosus tissue type plasminogen activator 0.0158 0.0219 0.0213
Trypanosoma brucei small myristoylated protein 1-1 0.041 0.0764 0.4671
Leishmania major cathepsin L-like protease 0.0187 0.0281 0.17
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0042 0.0086
Echinococcus multilocularis cyclins 0.0301 0.0528 0.0522
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Schistosoma mansoni amine GPCR 0.0494 0.0945 0.1106
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0073 0.0033 0.0028
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase isozyme 0.0111 0.0116 0.011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0494 0.0945 0.1106
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0417 0.0777 0.0772
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0494 0.0945 0.1106
Schistosoma mansoni cyclin l 0.0073 0.0033 0.0033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Mycobacterium tuberculosis Possible chitinase 0.0262 0.0443 0.787
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0395 0.073 0.4466
Schistosoma mansoni cathepsin F (C01 family) 0.0187 0.0281 0.0324
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0187 0.0281 0.0275
Brugia malayi GPI-anchor transamidase 0.006 0.0006 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Loa Loa (eye worm) hypothetical protein 0.0077 0.0042 0.0061
Onchocerca volvulus Cathepsin L homolog 0.0187 0.0281 0.2051
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Echinococcus multilocularis regulator of G protein signaling 3 0.0081 0.0051 0.0045
Mycobacterium leprae probable zinc metalloprotease 0.0312 0.0551 1
Brugia malayi calpain D 0.0282 0.0487 0.0706
Mycobacterium tuberculosis Possible oxidoreductase 0.0105 0.0104 0.1147
Echinococcus granulosus rhodopsin orphan GPCR 0.0494 0.0945 0.094
Echinococcus granulosus fibrillin 1 0.0062 0.0009 0.0004
Loa Loa (eye worm) hypothetical protein 0.0149 0.0199 0.0289
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0195 0.0299 0.1206
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0122 0.0141 0.0834
Echinococcus multilocularis cyclin G2 0.0073 0.0033 0.0028
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.0263 0.0446 0.2715
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 36 0.0063 0.0013 0.0007
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0129 0.0156 0.0358
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0494 0.0945 0.094
Trichomonas vaginalis cyclins, putative 0.0301 0.0528 0.1246
Trichomonas vaginalis conserved hypothetical protein 0.0665 0.1315 0.3126
Trypanosoma cruzi hypothetical protein, conserved 0.0263 0.0446 0.2715
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0051 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0215 0.0341 0.08
Echinococcus multilocularis cyclin y 0.0073 0.0033 0.0028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0494 0.0945 0.1106
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0196 0.0301 0.0436
Trypanosoma brucei Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0228 0.037 0.2243
Toxoplasma gondii histone lysine-specific demethylase 0.0105 0.0104 0.1463
Toxoplasma gondii cathepsin B 0.01 0.0093 0.1308
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0017 0.0024
Echinococcus granulosus regulator of G protein signaling 3 0.0081 0.0051 0.0045
Onchocerca volvulus Neuropeptide F receptor homolog 0.0494 0.0945 0.6898
Plasmodium vivax vivapain-2 0.0187 0.0281 0.3902
Toxoplasma gondii hypothetical protein 0.006 0.0006 0.0083
Leishmania major hypothetical protein, conserved 0.0263 0.0446 0.2715
Schistosoma mansoni opsin-like receptor 0.0494 0.0945 0.1106
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0266 0.0452 0.2752
Echinococcus granulosus Mastin 0.0077 0.0042 0.0036
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0518 0.0998 0.1167
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0271 0.0463 0.0538
Entamoeba histolytica cyclin, domain containing protein 0.0073 0.0033 0.0275
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0158 0.0219 0.3018
Mycobacterium ulcerans monoamine oxidase 0.0105 0.0104 0.0994
Loa Loa (eye worm) peptidase family M13 containing protein 0.023 0.0375 0.0543
Schistosoma mansoni family C12 unassigned peptidase (C12 family) 0.0122 0.0141 0.0159
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Schistosoma mansoni hypothetical protein 0.0061 0.0009 0.0004
Entamoeba histolytica cysteine protease, putative 0.0099 0.0091 0.0802
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0494 0.0945 0.094
Loa Loa (eye worm) hypoxia-induced factor 1 0.0297 0.0519 0.0752
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0073 0.0033 0.0392
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0187 0.0281 0.0657
Loa Loa (eye worm) hypothetical protein 0.0518 0.0998 0.1447
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0518 0.0998 0.0993
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0395 0.073 0.4466
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0122 0.0141 0.0838
Echinococcus granulosus regulator of G protein signaling 3 0.0081 0.0051 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0263 0.0446 0.2715
Echinococcus granulosus cyclins 0.0301 0.0528 0.0522
Trypanosoma cruzi cysteine peptidase, putative 0.0326 0.0581 0.355
Echinococcus multilocularis fmrfamide receptor 0.0494 0.0945 0.094
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase, putative 0.0111 0.0116 0.1026
Echinococcus granulosus neuropeptide Y receptor 0.0494 0.0945 0.094
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0077 0.0042 0.0061
Brugia malayi Cyclin, N-terminal domain containing protein 0.0565 0.1099 0.1595
Schistosoma mansoni ubiquitinyl hydrolase-UCH37 (C12 family) 0.0111 0.0116 0.0129
Trypanosoma cruzi trypanothione synthetase-like protein, putative 0.0066 0.0019 0.0087
Schistosoma mansoni hypothetical protein 0.0073 0.0033 0.0033
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0528 0.1018 0.6243
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.004 0.0083
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0215 0.0341 0.08
Schistosoma mansoni hypothetical protein 0.2823 0.5984 0.7034
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0494 0.0945 0.094
Brugia malayi hypothetical protein 0.0494 0.0945 0.1371
Trichomonas vaginalis conserved hypothetical protein 0.0665 0.1315 0.3126
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0234 0.0382 0.5362
Trypanosoma cruzi Aminopeptidase M1, putative 0.0114 0.0123 0.0729
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0192 0.0292 0.0337
Loa Loa (eye worm) TYRA-2 protein 0.0494 0.0945 0.1371
Brugia malayi Cyclin, N-terminal domain containing protein 0.0073 0.0033 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C19, putative 0.0102 0.0096 0.0559
Echinococcus granulosus Cyclin L1 0.0073 0.0033 0.0028
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0074 0.0036 0.0193
Onchocerca volvulus 0.0114 0.0123 0.0901
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0259 0.0436 0.043
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.007 0.0027 0.0133
Echinococcus granulosus membrane bound transcription factor site 1 0.0147 0.0194 0.0188
Schistosoma mansoni site-1 peptidase (S08 family) 0.0147 0.0194 0.0222
Echinococcus multilocularis aminopeptidase N 0.0388 0.0716 0.0711
Leishmania major subtilisin-like serine peptidase 0.0147 0.0194 0.1163
Echinococcus multilocularis g protein coupled receptor 0.0494 0.0945 0.094
Toxoplasma gondii cathepsin CPL 0.0187 0.0281 0.395
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0063 0.0013 0.0017
Loa Loa (eye worm) hypothetical protein 0.0236 0.0386 0.056
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Brugia malayi Cathepsin L-like precursor 0.0187 0.0281 0.0408
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.04 0.0741 0.4534
Echinococcus multilocularis GPCR, family 2 0.0061 0.0009 0.0003
Trichomonas vaginalis cyclin B3, putative 0.0301 0.0528 0.1246
Trypanosoma brucei trypanothione synthetase 0.0066 0.0019 0.0083
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0312 0.0551 0.0799
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase isozyme 0.0111 0.0116 0.011
Brugia malayi EGF-like domain containing protein 0.006 0.0006 0.0009
Brugia malayi Serotonin receptor 0.0494 0.0945 0.1371
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.029 0.0504 0.3073
Trypanosoma cruzi hypothetical protein, conserved 0.0328 0.0586 0.358
Loa Loa (eye worm) hypothetical protein 0.0518 0.0998 0.1447
Echinococcus multilocularis rhodopsin orphan GPCR 0.0494 0.0945 0.094
Entamoeba histolytica GPI-anchor transamidase, putative 0.006 0.0006 0.0024
Trypanosoma cruzi conserved protein 0.0426 0.0798 0.4883
Echinococcus granulosus GPCR family 2 0.0061 0.0009 0.0003
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0257 0.0432 0.2624
Plasmodium vivax calpain, putative 0.029 0.0504 0.7058
Echinococcus multilocularis calpain 0.0271 0.0463 0.0457
Echinococcus multilocularis axis inhibition protein axin 0.0081 0.0051 0.0045
Loa Loa (eye worm) hypothetical protein 0.0236 0.0386 0.056
Leishmania major UDP-galactopyranose mutase 0.0105 0.0104 0.0609
Brugia malayi Cathepsin L-like precursor 0.006 0.0006 0.0008
Brugia malayi Cyclin, N-terminal domain containing protein 0.0073 0.0033 0.0048
Echinococcus granulosus cyclin G2 0.0073 0.0033 0.0028
Entamoeba histolytica cyclin, putative 0.0301 0.0528 0.4783
Entamoeba histolytica cysteine proteinase, putative 0.0127 0.0152 0.1354
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.0194 0.0449
Schistosoma mansoni cathepsin D (A01 family) 0.0567 0.1102 0.129
Brugia malayi hypothetical protein 0.0114 0.0123 0.0179
Onchocerca volvulus 0.0077 0.0042 0.0306
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0478 0.091 0.5577
Entamoeba histolytica cyclin, domain containing protein 0.0073 0.0033 0.0275
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0079 0.0046 0.0253
Brugia malayi Cyclin, N-terminal domain containing protein 0.0301 0.0528 0.0765
Schistosoma mansoni hypothetical protein 0.0077 0.0042 0.0043
Loa Loa (eye worm) hypothetical protein 0.1249 0.2578 0.374
Brugia malayi Trypsin family protein 0.0077 0.0042 0.0061
Echinococcus granulosus sex peptide receptor 0.0494 0.0945 0.094
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0528 0.1018 0.6243
Echinococcus multilocularis g protein coupled receptor 0.0494 0.0945 0.094
Schistosoma mansoni axis inhibition protein axin 0.0081 0.0051 0.0053
Brugia malayi Cyclin C 0.0073 0.0033 0.0048
Trypanosoma brucei calpain-like protein, putative 0.0528 0.1018 0.6242
Brugia malayi Dopamine receptor protein 2 0.0494 0.0945 0.1371
Schistosoma mansoni hypothetical protein 0.0081 0.0052 0.0055
Entamoeba histolytica cysteine protease, putative 0.0099 0.0091 0.0802
Trypanosoma brucei pyroglutamyl-peptidase I, putative 0.0422 0.079 0.4834
Echinococcus granulosus tm gpcr rhodopsin 0.0494 0.0945 0.094
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0063 0.0013 0.009
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0192 0.0292 0.1766
Brugia malayi larval opioid receptor 0.0494 0.0945 0.1371
Trypanosoma cruzi trypanothione synthetase, putative 0.0066 0.0019 0.0087
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0076 0.004 0.0041
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.081 0.1628 1
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0073 0.0033 0.0468
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0105 0.0104 0.0994
Echinococcus granulosus neuropeptides capa receptor 0.0494 0.0945 0.094
Schistosoma mansoni family C19 unassigned peptidase (C19 family) 0.0102 0.0096 0.0107
Echinococcus multilocularis calpain 5 0.0271 0.0463 0.0457
Echinococcus granulosus g protein coupled receptor 0.0494 0.0945 0.094
Plasmodium falciparum cyclin 0.0301 0.0528 0.7393
Echinococcus granulosus cyclin G2 0.0073 0.0033 0.0028
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0114 0.0123 0.0118
Trypanosoma cruzi trypanothione synthetase 0.0066 0.0019 0.0087
Loa Loa (eye worm) hypothetical protein 0.0194 0.0296 0.043
Leishmania major cathepsin L-like protease 0.0326 0.0581 0.355
Trypanosoma brucei calpain-like protein, putative 0.029 0.0504 0.307
Echinococcus granulosus neuropeptide Y receptor 0.0494 0.0945 0.094
Brugia malayi putative neuropeptide receptor NPR1 0.0494 0.0945 0.1371
Brugia malayi Ubiquitin carboxyl-terminal hydrolase, family 1 protein 0.0122 0.0141 0.0205
Echinococcus granulosus G protein coupled receptor 139 0.0494 0.0945 0.094
Echinococcus granulosus lysine specific histone demethylase 1A 0.0105 0.0104 0.0098
Onchocerca volvulus 0.0494 0.0945 0.6898
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.04 0.0741 0.4534
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0357 0.0648 0.3958
Loa Loa (eye worm) hypothetical protein 0.0058 0.0002 0.0003
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0114 0.0123 0.0139
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0494 0.0945 0.1106
Echinococcus multilocularis glycoprotein Antigen 5 0.0077 0.0042 0.0036
Brugia malayi ubiquitin specific protease 14 0.007 0.0027 0.0039
Echinococcus granulosus cyclins 0.0073 0.0033 0.0028
Entamoeba histolytica cysteine proteinase, putative 0.0099 0.0091 0.0802
Trypanosoma brucei Aminopeptidase M1, putative 0.0114 0.0123 0.0725
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0558 0.1084 0.6646
Brugia malayi Cathepsin L-like cysteine proteinase 0.0127 0.0152 0.022
Brugia malayi hypothetical protein 0.0395 0.0731 0.1061
Mycobacterium ulcerans hypothetical protein 0.0097 0.0087 0.0759
Loa Loa (eye worm) proprotein convertase 2 0.0812 0.1633 0.2368
Echinococcus multilocularis integrin alpha 3 0.059 0.1153 0.1148
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Brugia malayi hypothetical protein 0.0494 0.0945 0.1371
Echinococcus granulosus cysteine protease atg4b 0.0081 0.0051 0.0045
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0129 0.0156 0.0925
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0326 0.0581 0.3548
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0228 0.037 0.2243
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0097 0.0086 0.0495
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0017 0.0122
Trypanosoma cruzi glutathionylspermidine synthase, putative 0.0066 0.0019 0.0087
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0147 0.0194 0.1163
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0147 0.0194 0.116
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0177 0.0259 0.1561
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0649 0.128 0.7855
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0494 0.0945 0.094
Trypanosoma brucei hypothetical protein 0.0471 0.0896 0.5488
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0064 0.0015 0.0022
Schistosoma mansoni cyclins 0.0301 0.0528 0.0614
Plasmodium vivax subtilisin-like protease 1 0.0147 0.0194 0.2668
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0473 0.0899 0.0893
Schistosoma mansoni tyrosine kinase 0.0081 0.0051 0.0053
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.016 0.0222 0.0254
Trichomonas vaginalis cyclins, putative 0.0565 0.1099 0.2612
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0619 0.1215 0.7454
Echinococcus multilocularis protein jagged 2 0.006 0.0006 0.0000067591
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0076 0.004 0.0491
Plasmodium falciparum cysteine repeat modular protein 1 0.0158 0.0219 0.3016
Trichomonas vaginalis conserved hypothetical protein 0.0328 0.0586 0.1386
Echinococcus multilocularis cyclins 0.0301 0.0528 0.0522
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0042 0.0225
Loa Loa (eye worm) hypothetical protein 0.0236 0.0386 0.056
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0061 0.0007 0.0008
Loa Loa (eye worm) peptidase family M1 containing protein 0.0314 0.0556 0.0806
Onchocerca volvulus 0.0494 0.0945 0.6898
Echinococcus multilocularis integrin alpha ps 0.0345 0.0623 0.0618
Mycobacterium tuberculosis Conserved hypothetical protein 0.0105 0.0104 0.1147
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0157 0.0216 0.0248
Onchocerca volvulus 0.0562 0.1093 0.7973
Brugia malayi SWIRM domain containing protein 0.0562 0.1093 0.1585
Schistosoma mansoni hypothetical protein 0.0494 0.0945 0.1106
Brugia malayi Protein kinase domain containing protein 0.0159 0.0221 0.032
Onchocerca volvulus 0.0494 0.0945 0.6898
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0417 0.0777 0.0772
Brugia malayi neuropeptide F receptor 0.0494 0.0945 0.1371
Schistosoma mansoni biogenic amine receptor 0.0494 0.0945 0.1106
Brugia malayi hypothetical protein 0.0077 0.0042 0.0061
Echinococcus multilocularis calpain family protein 1, d 0.0215 0.0341 0.0335
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0105 0.0104 0.1394
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0307 0.054 0.3295
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.0006 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0494 0.0945 0.094
Trichomonas vaginalis cyclin B, putative 0.0073 0.0033 0.0066
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase, putative 0.007 0.0027 0.03
Entamoeba histolytica cysteine protease, putative 0.0099 0.0091 0.0802
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0147 0.0194 0.1163
Schistosoma mansoni sortilin 0.02 0.0308 0.0356
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0105 0.0104 0.1463
Brugia malayi hypothetical protein 0.0494 0.0945 0.1371
Echinococcus granulosus neuropeptides capa receptor 0.0494 0.0945 0.094
Echinococcus multilocularis hypothetical protein 0.0271 0.0463 0.0457
Schistosoma mansoni integrin alpha-ps 0.0345 0.0623 0.0726
Echinococcus granulosus tachykinin peptides receptor 99D 0.0494 0.0945 0.094
Entamoeba histolytica cysteine protease inhibitor 2 (EhICP2) 0.023 0.0373 0.3377
Echinococcus multilocularis Mastin 0.0077 0.0042 0.0036
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0494 0.0945 0.094
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.04 0.0741 0.4532
Echinococcus multilocularis calpain 7 (C02 family) 0.0302 0.053 0.0525
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Echinococcus multilocularis transmembrane protease serine 3 0.0077 0.0042 0.0036
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 12 0.0071 0.0031 0.0025
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0017 0.007
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 36 0.0063 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.007 0.0027 0.005
Echinococcus granulosus enteropeptidase 0.0077 0.0042 0.0036
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0767 0.1537 0.9435
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Brugia malayi Cathepsin L-like precursor 0.0187 0.0281 0.0408
Trichomonas vaginalis Clan CA, family C12, ubiquitin hydrolase-like cysteine peptidase 0.0122 0.0141 0.0323
Brugia malayi Dopamine receptor 0.0494 0.0945 0.1371
Schistosoma mansoni patched 1 0.0171 0.0247 0.0284
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0473 0.0899 0.1303
Trypanosoma brucei glutathionylspermidine synthetase, putative 0.0066 0.0019 0.0083
Trypanosoma cruzi unspecified product 0.041 0.0764 0.4673
Echinococcus multilocularis 0.2579 0.5456 0.5454
Plasmodium falciparum calpain 0.0234 0.0382 0.5324
Onchocerca volvulus 0.0494 0.0945 0.6898
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0558 0.1084 0.6647
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0254 0.0426 0.2595
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0079 0.0046 0.0048
Giardia lamblia Cyclin fold protein 1, putative 0.0073 0.0033 0.0113
Echinococcus granulosus rhodopsin orphan GPCR 0.0494 0.0945 0.094
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0147 0.0194 0.2197
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0494 0.0945 0.1106
Trichomonas vaginalis cyclins, putative 0.0565 0.1099 0.2612
Echinococcus multilocularis cyclin t1 0.0073 0.0033 0.0028
Brugia malayi Integrin beta pat-3 precursor 0.2577 0.5453 0.7908
Trypanosoma brucei amidase, putative 0.0066 0.0019 0.0083
Echinococcus granulosus Ubiquitin thioesterase otubain protein 0.0084 0.0059 0.0053
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0081 0.0051 0.0053
Brugia malayi ubiquitin C-terminal hydrolase UCH-L5 0.0111 0.0116 0.0168
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0076 0.0042 0.0147
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0312 0.0551 0.0641
Trypanosoma brucei Aminopeptidase M1, putative 0.0114 0.0123 0.0725
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0641 0.1263 0.775
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0147 0.0194 0.2014
Echinococcus multilocularis cysteine protease 0.0187 0.0281 0.0275
Loa Loa (eye worm) TK/ROR protein kinase 0.0159 0.0221 0.032
Echinococcus multilocularis cyclin G2 0.0073 0.0033 0.0028
Schistosoma mansoni amine GPCR 0.0494 0.0945 0.1106
Entamoeba histolytica cysteine proteinase 1, putative 0.0099 0.0091 0.0802
Loa Loa (eye worm) hypothetical protein 0.0081 0.0051 0.0074
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0257 0.0432 0.2624
Brugia malayi amine oxidase, flavin-containing family protein 0.0149 0.0199 0.0289
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Schistosoma mansoni hypothetical protein 0.0215 0.0341 0.0394
Trypanosoma brucei mitotic cyclin 6 0.0565 0.1099 0.6741
Brugia malayi Endochitinase 0.0307 0.0541 0.0785
Trypanosoma brucei Calpain-like protein 2 0.0601 0.1177 0.7221
Loa Loa (eye worm) neuropeptide F receptor 0.0494 0.0945 0.1371
Echinococcus granulosus nmda type glutamate receptor 0.0109 0.0113 0.0107
Echinococcus multilocularis G-protein coupled receptor, putative 0.0494 0.0945 0.094
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0271 0.0463 0.0538
Leishmania major mitotic cyclin, putative 0.0073 0.0033 0.0174
Trypanosoma cruzi cysteine peptidase, Clan CD, family C13, putative 0.006 0.0006 0.0004
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0105 0.0104 0.0994
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0042 0.0043
Echinococcus granulosus peptide allatostatin:somatostatin 0.0494 0.0945 0.094
Trypanosoma brucei Calpain-like protein 1.2 0.0619 0.1215 0.7453
Brugia malayi Kringle domain containing protein 0.0158 0.0219 0.0317
Loa Loa (eye worm) cyclin domain-containing protein 0.0073 0.0033 0.0048
Onchocerca volvulus 0.0187 0.0281 0.2051
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0116 0.0126 0.012
Echinococcus granulosus cathepsin b 0.01 0.0093 0.0087
Leishmania major ubiqitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0102 0.0096 0.0562
Loa Loa (eye worm) hypothetical protein 0.0127 0.0152 0.022
Loa Loa (eye worm) hypothetical protein 0.018 0.0265 0.0384
Toxoplasma gondii cyclin 4, putative 0.0073 0.0033 0.0468
Echinococcus multilocularis cathepsin L 0.0099 0.0091 0.0085
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0611 0.1199 0.7356
Leishmania major META domain containing protein 0.0263 0.0446 0.2715
Toxoplasma gondii ubiquitin thioesterase otubain-like family protein 0.0084 0.0059 0.0824
Schistosoma mansoni hypothetical protein 0.0316 0.0559 0.0651
Brugia malayi CG8232-PA 0.0058 0.0002 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.0281 0.0657
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0641 0.1263 0.775
Schistosoma mansoni hypothetical protein 0.0665 0.1315 0.154
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0187 0.0281 0.0408
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0042 0.0043
Schistosoma mansoni amine GPCR 0.0494 0.0945 0.1106
Brugia malayi CHE-14 protein 0.0171 0.0247 0.0358
Loa Loa (eye worm) hypothetical protein 0.006 0.0006 0.0008
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0192 0.0292 0.0286
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0063 0.0013 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.01 0.0093 0.0208
Trypanosoma cruzi subtilisin peptidase 0.0147 0.0194 0.1163
Echinococcus granulosus baculoviral IAP repeat containing protein 0.016 0.0222 0.0216
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0357 0.0648 0.3961
Brugia malayi Trypsin-like protease protein 5 0.0077 0.0042 0.0061
Echinococcus multilocularis serotonin receptor 0.0494 0.0945 0.094
Trichomonas vaginalis conserved hypothetical protein 0.0665 0.1315 0.3126
Onchocerca volvulus 0.0494 0.0945 0.6898
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.081 0.1628 1
Leishmania major inhibitor of cysteine peptidase 0.023 0.0373 0.2268
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0042 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0051 0.0107
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0153 0.0208 0.1247
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0391 0.0723 0.442
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Trypanosoma cruzi hypothetical protein, conserved 0.0158 0.0219 0.1316
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0494 0.0945 0.1106
Schistosoma mansoni biogenic amine receptor 0.0494 0.0945 0.1106
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0081 0.0051 0.0045
Loa Loa (eye worm) hypothetical protein 0.0262 0.0443 0.0643
Onchocerca volvulus Deterin homolog 0.016 0.0222 0.1616
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0187 0.0281 0.0657
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0017 0.007
Trypanosoma cruzi cyclin 9, putative 0.0073 0.0033 0.0174
Brugia malayi cathepsin B-like cysteine proteinase 0.01 0.0093 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0033 0.0066
Echinococcus granulosus cyclins 0.0301 0.0528 0.0522
Mycobacterium ulcerans oxidoreductase 0.0105 0.0104 0.0994
Loa Loa (eye worm) hypothetical protein 0.0081 0.0051 0.0074
Echinococcus granulosus 7tm_1 domain containing protein 0.0494 0.0945 0.094
Brugia malayi Melatonin receptor type 1A 0.0494 0.0945 0.1371
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0228 0.037 0.2246
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase UCHL3 0.0122 0.0141 0.1984
Schistosoma mansoni regulator of G protein signaling 0.0081 0.0051 0.0053
Schistosoma mansoni hypothetical protein 0.0081 0.0052 0.0055
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0157 0.0216 0.0248
Brugia malayi hypothetical protein 0.0322 0.0573 0.0831
Echinococcus multilocularis fmrfamide receptor 0.0494 0.0945 0.094
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.01 0.0093 0.0103
Trypanosoma brucei small myristoylated protein 1-2 0.041 0.0764 0.4671
Loa Loa (eye worm) trypsin family protein 0.0077 0.0042 0.0061
Loa Loa (eye worm) subtilase 0.0147 0.0194 0.0281
Toxoplasma gondii subtilisin SUB1 0.0147 0.0194 0.2726
Schistosoma mansoni integrin alpha-ps 0.018 0.0265 0.0305
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase family 2, putative 0.0078 0.0045 0.0559
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.007 0.0027 0.0133
Onchocerca volvulus 0.0494 0.0945 0.6898
Schistosoma mansoni hypothetical protein 0.016 0.0222 0.0254
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.0301 0.0347
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0042 0.0043
Trichomonas vaginalis cyclin A, putative 0.0073 0.0033 0.0066
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0163 0.0229 0.1378
Brugia malayi regulator of G-protein signaling egl-10 0.0081 0.0051 0.0074
Echinococcus multilocularis enteropeptidase 0.0077 0.0042 0.0036
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0071 0.0031 0.0157
Echinococcus multilocularis rhodopsin orphan GPCR 0.0494 0.0945 0.094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0494 0.0945 0.1106
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0187 0.0281 0.39
Toxoplasma gondii sortilin, putative 0.0282 0.0486 0.6829
Leishmania major cathepsin L-like protease 0.0187 0.0281 0.17
Trichomonas vaginalis conserved hypothetical protein 0.0665 0.1315 0.3126
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0073 0.0033 0.017
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Schistosoma mansoni cyclin d 0.0073 0.0033 0.0033
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.007 0.0027 0.0039
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0105 0.0104 0.1392
Onchocerca volvulus 0.0494 0.0945 0.6898
Loa Loa (eye worm) hypothetical protein 0.006 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0081 0.0051 0.0074
Entamoeba histolytica cyclin family protein 0.0301 0.0528 0.4783
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0601 0.1177 0.7222
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.01 0.0093 0.0103
Echinococcus multilocularis cyclins 0.0301 0.0528 0.0522
Trypanosoma cruzi hypothetical protein, conserved 0.0263 0.0446 0.2715
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Loa Loa (eye worm) hypothetical protein 0.006 0.0006 0.0009
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase isozyme 0.0122 0.0141 0.0135
Echinococcus multilocularis adam 0.006 0.0006 0.0000067591
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0114 0.0123 0.0729
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0207 0.0324 0.1966
Toxoplasma gondii subtilisin SUB5 0.0147 0.0194 0.2726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.0281 0.0657
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0494 0.0945 0.1371
Trichomonas vaginalis conserved hypothetical protein 0.0665 0.1315 0.3126
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0195 0.0299 0.07
Echinococcus granulosus orexin receptor type 2 0.0494 0.0945 0.094
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0019 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0301 0.0528 0.1246
Trichomonas vaginalis conserved hypothetical protein 0.0665 0.1315 0.3126
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0494 0.0945 0.094
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Onchocerca volvulus Cyclin L homolog 0.0073 0.0033 0.0243
Toxoplasma gondii subtilisin SUB6 0.0147 0.0194 0.2726
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0587 0.1147 0.7035
Brugia malayi hypothetical protein 0.0494 0.0945 0.1371
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.007 0.0027 0.0129
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.0263 0.0446 0.2715
Toxoplasma gondii hypothetical protein 0.0215 0.0341 0.4787
Loa Loa (eye worm) hypothetical protein 0.0105 0.0104 0.0151
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0812 0.1633 0.3886
Brugia malayi Cathepsin L-like precursor 0.0187 0.0281 0.0408
Brugia malayi hypothetical protein 0.0105 0.0104 0.0151
Schistosoma mansoni family C12 unassigned peptidase (C12 family) 0.0122 0.0141 0.0159
Leishmania major hypothetical protein, conserved 0.0263 0.0446 0.2715
Loa Loa (eye worm) hypothetical protein 0.0192 0.0292 0.0423
Leishmania major D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative 0.0307 0.054 0.3295
Loa Loa (eye worm) hypothetical protein 0.0127 0.0152 0.022
Brugia malayi Cathepsin L-like precursor 0.0127 0.0152 0.022
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0195 0.0299 0.07
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0111 0.0116 0.0681
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0456 0.0863 0.5286
Schistosoma mansoni ubiquitin-specific peptidase 46 (C19 family) 0.0071 0.0031 0.0029
Echinococcus granulosus integrin alpha 3 0.059 0.1153 0.1148
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0042 0.0043
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0665 0.1315 0.3126
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0064 0.0015 0.0022
Echinococcus granulosus rhodopsin orphan GPCR 0.0494 0.0945 0.094
Echinococcus multilocularis rhodopsin orphan GPCR 0.0494 0.0945 0.094
Onchocerca volvulus 0.0077 0.0042 0.0306
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0079 0.0046 0.5
Loa Loa (eye worm) calpain family protein 1 0.0215 0.0341 0.0494
Onchocerca volvulus 0.0158 0.0219 0.1596
Loa Loa (eye worm) cyclin domain-containing protein 0.0073 0.0033 0.0048
Echinococcus multilocularis cyclin B 0.0565 0.1099 0.1094
Schistosoma mansoni hypothetical protein 0.0082 0.0054 0.0057
Leishmania major cysteine peptidase A (CPA) 0.0187 0.0281 0.17
Echinococcus multilocularis g protein coupled receptor 0.0494 0.0945 0.094
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0147 0.0194 0.1163
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0558 0.1084 0.6647
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0187 0.0281 0.0657
Leishmania major cyclin 0.0565 0.1099 0.6742
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0187 0.0281 0.0657
Echinococcus multilocularis integrin beta 2 0.1903 0.3994 0.399
Trypanosoma cruzi cysteine proteinase, putative 0.0099 0.0091 0.053
Echinococcus granulosus cyclins 0.0301 0.0528 0.0522
Echinococcus multilocularis ubiquitin specific protease 41 0.0076 0.0042 0.0036
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0558 0.1084 0.6647
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0307 0.054 0.3295
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0494 0.0945 0.1371
Plasmodium falciparum plasmepsin I 0.0192 0.0292 0.4054
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0263 0.0446 0.2715
Echinococcus granulosus neuropeptide receptor 0.126 0.2603 0.2598
Plasmodium vivax unspecified product 0.0099 0.0091 0.1211
Trypanosoma brucei cysteine peptidase C (CPC) 0.01 0.0093 0.0538
Schistosoma mansoni serine-type protease inhibitor 0.3988 0.8506 1
Onchocerca volvulus 0.0101 0.0096 0.0697
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0076 0.004 0.0142
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0073 0.0033 0.0048
Trypanosoma cruzi cysteine peptidase, putative 0.0326 0.0581 0.355
Echinococcus granulosus neuropeptide FF receptor 2 0.0972 0.1979 0.1974
Onchocerca volvulus Protein CNPPD1 homolog 0.0073 0.0033 0.0243
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0494 0.0945 0.1106
Loa Loa (eye worm) hypothetical protein 0.0236 0.0386 0.056
Brugia malayi Furin-like cysteine rich region family protein 0.0507 0.0973 0.1411
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0215 0.0341 0.08
Leishmania major hypothetical protein, conserved 0.0263 0.0446 0.2715
Loa Loa (eye worm) hypothetical protein 0.0348 0.0629 0.0913
Trypanosoma brucei cysteine peptidase, Clan CA, family C51, putative 0.0307 0.054 0.3292
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 20 0.0102 0.0096 0.0091
Schistosoma mansoni calpain (C02 family) 0.0271 0.0463 0.0538
Echinococcus granulosus endothelin converting enzyme 1 0.0312 0.0551 0.0545
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Brugia malayi calpain 5 0.0215 0.0341 0.0494
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0105 0.0104 0.1394
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0194 0.0296 0.043
Leishmania major GPI-anchor transamidase subunit 8 (GPI8), putative 0.006 0.0006 0.0004
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0081 0.0051 0.0107
Loa Loa (eye worm) hypothetical protein 0.0972 0.1979 0.287
Mycobacterium ulcerans dehydrogenase 0.0105 0.0104 0.0994
Schistosoma mansoni hypothetical protein 0.0061 0.0009 0.0004
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0114 0.0123 0.0281
Schistosoma mansoni cyclin B3 0.0301 0.0528 0.0614
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0114 0.0123 0.0118
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Loa Loa (eye worm) hypothetical protein 0.0081 0.0051 0.0074
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0271 0.0463 0.0457
Brugia malayi calpain family protein 1 0.0271 0.0463 0.0671
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0097 0.0086 0.008
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.01 0.0093 0.0103
Leishmania major otubain, putative,otubain cysteine peptidase, Clan CA, family C65, putative 0.0084 0.0059 0.0329
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0157 0.0216 0.0248
Brugia malayi proprotein convertase 2 0.2061 0.4335 0.6287
Leishmania major hypothetical protein, conserved 0.0066 0.0019 0.0087
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0017 0.0011
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0114 0.0123 0.0725
Schistosoma mansoni inhibitor of apoptosis protein 0.016 0.0222 0.0254
Echinococcus granulosus neuropeptide receptor 0.0494 0.0945 0.094
Schistosoma mansoni regulator of G protein signaling 0.0081 0.0051 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.0281 0.0657
Toxoplasma gondii subtilisin SUB4 0.0147 0.0194 0.2726
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.016 0.0222 0.0321
Loa Loa (eye worm) hypothetical protein 0.006 0.0006 0.0008
Echinococcus multilocularis neuropeptides capa receptor 0.0494 0.0945 0.094
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0099 0.0091 0.0101
Schistosoma mansoni hypothetical protein 0.0073 0.0033 0.0033
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.029 0.0504 0.3073
Trichomonas vaginalis conserved hypothetical protein 0.0665 0.1315 0.3126
Echinococcus granulosus tm gpcr rhodopsin 0.0494 0.0945 0.094
Echinococcus granulosus cysteine protease 0.0099 0.0091 0.0085
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0192 0.0292 0.0423
Leishmania major cathepsin L-like protease 0.0187 0.0281 0.17
Schistosoma mansoni ubiquitinyl hydrolase-UCH37 (C12 family) 0.0111 0.0116 0.0129
Loa Loa (eye worm) ubiquitin C-terminal hydrolase UCH-L5 0.0111 0.0116 0.0168
Echinococcus granulosus neuropeptide s receptor 0.0959 0.195 0.1946
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0114 0.0123 0.0118
Echinococcus granulosus fibrillin 2 0.006 0.0006 0.0000067591
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0587 0.1147 0.7035
Mycobacterium ulcerans aminopeptidase N PepN 0.0114 0.0123 0.1252
Trypanosoma cruzi otubain cysteine peptidase, Clan CA, family C65, putative 0.0084 0.0059 0.0329
Giardia lamblia Cathepsin B precursor 0.01 0.0093 0.0359
Loa Loa (eye worm) cyclin domain-containing protein 0.0073 0.0033 0.0048
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0192 0.0292 0.1766
Brugia malayi Trypsin family protein 0.0691 0.1371 0.1988
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 20 0.0102 0.0096 0.0091
Brugia malayi A-kinase anchor protein 10, precursor 0.0081 0.0051 0.0074
Loa Loa (eye worm) hypothetical protein 0.016 0.0222 0.0321
Trypanosoma cruzi CYC2-like cyclin, putative 0.0565 0.1099 0.6742
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0326 0.0581 0.3548
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0114 0.0123 0.0729
Leishmania major small myristoylated protein-1 0.041 0.0764 0.4673
Plasmodium vivax ubiquitin C-terminal hydrolase, family 1, putative 0.0111 0.0116 0.1558
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Loa Loa (eye worm) G-protein coupled receptor 0.0494 0.0945 0.1371
Loa Loa (eye worm) hypothetical protein 0.0195 0.0297 0.0431
Onchocerca volvulus 0.0071 0.003 0.0217
Giardia lamblia High cysteine membrane protein Group 2 0.1183 0.2436 1
Plasmodium vivax subtilisin-like protease 2, putative 0.0147 0.0194 0.2668
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0153 0.0208 0.1244
Entamoeba histolytica cysteine protease, putative 0.0099 0.0091 0.0802
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0097 0.0086 0.0125
Echinococcus multilocularis regulator of G protein signaling 7 0.0081 0.0051 0.0045
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0417 0.0777 0.0908
Trypanosoma brucei Calpain-like protein 1.1 0.081 0.1628 1
Schistosoma mansoni hypothetical protein 0.0494 0.0945 0.1106
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0192 0.0292 0.1762
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 5 0.0074 0.0036 0.0031
Onchocerca volvulus 0.0154 0.021 0.1534
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0102 0.0096 0.0562
Leishmania major hypothetical protein, conserved 0.0263 0.0446 0.2715
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0391 0.0723 0.442
Echinococcus granulosus g protein coupled receptor 0.0494 0.0945 0.094
Echinococcus multilocularis epidermal growth factor receptor 0.0507 0.0973 0.0968
Leishmania major cathepsin L-like protease 0.0326 0.0581 0.355
Echinococcus multilocularis Niemann Pick C1 protein 0.0171 0.0247 0.0241
Trypanosoma cruzi cysteine peptidase inhibitor 0.023 0.0373 0.2268
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0097 0.0086 0.0125
Trypanosoma cruzi small myristoylated protein 1-2 0.041 0.0764 0.4673
Onchocerca volvulus Cyclin L homolog 0.0073 0.0033 0.0243
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0077 0.0042 0.0036
Schistosoma mansoni neuropeptide f receptor 76f 0.0494 0.0945 0.1106
Schistosoma mansoni tyrosine kinase 0.008 0.0049 0.0051
Brugia malayi hypothetical protein 0.0073 0.0033 0.0048
Schistosoma mansoni regulator of G protein signaling 0.0081 0.0051 0.0053
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0528 0.1018 0.6243
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0528 0.1018 0.6243
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.1995 0.4193 0.4189
Echinococcus multilocularis Peptidase C54 0.0081 0.0051 0.0045
Brugia malayi PXA domain containing protein 0.0081 0.0051 0.0074
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0153 0.0208 0.1865
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-5 0.0263 0.0446 0.2712
Loa Loa (eye worm) cyclin domain-containing protein 0.0073 0.0033 0.0048
Schistosoma mansoni single-minded 0.0096 0.0084 0.0092
Leishmania major hypothetical protein, conserved 0.0158 0.0219 0.1316
Schistosoma mansoni tyrosine kinase 0.0081 0.0051 0.0053
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0099 0.0091 0.0101
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0812 0.1633 0.3886
Brugia malayi Cathepsin L-like precursor 0.0187 0.0281 0.0408
Schistosoma mansoni amine oxidase 0.0105 0.0104 0.0116
Trypanosoma brucei antigen, putative 0.0271 0.0463 0.2818
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0073 0.0033 0.0028
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 14 0.007 0.0027 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0338 0.0608 0.3709
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0061 0.0009 0.0003
Echinococcus granulosus cathepsin b 0.01 0.0093 0.0087
Schistosoma mansoni hypothetical protein 0.0069 0.0026 0.0023
Brugia malayi PXA domain containing protein 0.0081 0.0051 0.0074
Leishmania major small myristoylated protein 4, putative 0.0611 0.1199 0.7356
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0051 0.0107
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0417 0.0777 0.4755
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase, family 1 protein 0.0111 0.0116 0.1625
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0187 0.0281 0.39
Echinococcus granulosus somatostatin receptor 0.0494 0.0945 0.094
Leishmania major hypothetical protein, conserved 0.0263 0.0446 0.2715
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0153 0.0208 0.1247
Schistosoma mansoni neprilysin 0.0081 0.0052 0.0055
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0494 0.0945 0.094
Echinococcus multilocularis cyclins 0.0301 0.0528 0.0522
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0494 0.0945 0.1371
Echinococcus granulosus c-Jun N-terminal kinases 0.0473 0.0899 0.0893
Toxoplasma gondii peptidase c13 family protein 0.006 0.0006 0.0082
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0494 0.0945 0.1106
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0076 0.0042 0.0036
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0215 0.0341 0.2064
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0042 0.0086
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0111 0.0116 0.0681
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0105 0.0104 0.0994
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 23 0.0063 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Schistosoma mansoni integrin alpha 0.077 0.1542 0.1808
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0494 0.0945 0.1106
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0081 0.0051 0.0053
Echinococcus granulosus lysine specific histone demethylase 1A 0.0518 0.0998 0.0993
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0494 0.0945 0.1106
Trypanosoma brucei RNA helicase, putative 0.0316 0.0559 0.3409
Echinococcus granulosus Protein patched homolog 1 0.0171 0.0247 0.0241
Loa Loa (eye worm) CYL-1 protein 0.0073 0.0033 0.0048
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0619 0.1215 0.7454
Onchocerca volvulus CoRest homolog 0.0195 0.0297 0.2167
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0076 0.0042 0.0036
Trypanosoma brucei hypothetical protein, conserved 0.0328 0.0586 0.3577
Brugia malayi neuropeptide F receptor 0.0494 0.0945 0.1371
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0386 0.0712 1
Echinococcus granulosus adam 0.006 0.0006 0.0000067591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0099 0.0091 0.0526
Brugia malayi neuroendocrine convertase 1 precursor 0.2061 0.4335 0.6287
Giardia lamblia Furin precursor putative serine protease 0.0665 0.1315 0.5386
Echinococcus granulosus alpha 1A adrenergic receptor 0.0494 0.0945 0.094
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0099 0.0091 0.0101
Echinococcus multilocularis neuropeptide Y receptor 0.0494 0.0945 0.094
Onchocerca volvulus 0.0187 0.0281 0.2051
Schistosoma mansoni ubiquitin-specific peptidase 14 (C19 family) 0.007 0.0027 0.0025
Brugia malayi EGF-like domain containing protein 0.006 0.0006 0.0009
Giardia lamblia Cathepsin B precursor 0.01 0.0093 0.0359
Plasmodium falciparum sortilin 0.0282 0.0486 0.6803
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0077 0.0042 0.0036
Plasmodium vivax hypothetical protein, conserved 0.0105 0.0104 0.1394
Brugia malayi Integrin alpha pat-2 precursor 0.077 0.1542 0.2237
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0042 0.0221
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0077 0.0042 0.0043
Toxoplasma gondii subtilisin SUB10 0.0147 0.0194 0.2726
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0307 0.054 0.3295
Echinococcus granulosus cyclin k 0.0073 0.0033 0.0028
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0102 0.0096 0.0562
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0187 0.0281 0.0657
Schistosoma mansoni hypothetical protein 0.0061 0.0009 0.0004
Trichomonas vaginalis cyclin B, putative 0.0565 0.1099 0.2612
Trypanosoma cruzi Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0071 0.0031 0.0157
Echinococcus granulosus glycoprotein Antigen 5 0.0077 0.0042 0.0036
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Schistosoma mansoni hypothetical protein 0.0494 0.0945 0.1106
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0063 0.0013 0.0049
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0228 0.037 0.2246
Echinococcus multilocularis expressed protein 0.1164 0.2394 0.239
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0017 0.0013
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0164 0.0232 0.0336
Plasmodium vivax cyclin homologue, putative 0.0073 0.0033 0.0392
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449
Plasmodium falciparum cysteine proteinase falcipain 3 0.0187 0.0281 0.39
Trypanosoma cruzi small myristoylated protein 1-1 0.041 0.0764 0.4673
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0812 0.1633 0.1914
Entamoeba histolytica aminopeptidase, putative 0.0114 0.0123 0.1097
Trichomonas vaginalis calpain, putative 0.0215 0.0341 0.08
Loa Loa (eye worm) endoprotease bli-4 0.3244 0.6895 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0691 0.1371 0.1606
Onchocerca volvulus Putative endochitinase 0.0307 0.0541 0.3948
Onchocerca volvulus 0.0073 0.0033 0.0243
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0494 0.0945 0.1106
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0077 0.0042 0.0036
Onchocerca volvulus 0.0187 0.0281 0.2051
Mycobacterium ulcerans hypothetical protein 0.0077 0.0042 0.0162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0326 0.0581 0.3548
Schistosoma mansoni hypothetical protein 0.0081 0.0052 0.0055
Toxoplasma gondii exonuclease 0.006 0.0005 0.0073
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.01 0.0093 0.0103
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0077 0.0042 0.0036
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0478 0.091 0.5577
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0326 0.0581 0.3548
Schistosoma mansoni biogenic amine receptor 0.0494 0.0945 0.1106
Leishmania major small myristoylated protein-2 0.0697 0.1385 0.8503
Echinococcus granulosus integrin alpha ps 0.0345 0.0623 0.0618
Echinococcus granulosus cyclin B 0.0565 0.1099 0.1094
Schistosoma mansoni tyrosine kinase 0.008 0.0049 0.0051
Loa Loa (eye worm) calpain D 0.0282 0.0487 0.0706
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0494 0.0945 0.1371
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0116 0.0126 0.0183
Brugia malayi cathepsin L-like precursor 0.0127 0.0152 0.022
Schistosoma mansoni axis inhibition protein axin 0.0081 0.0051 0.0053
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Leishmania major calpain family cysteine protease-like protein 0.0545 0.1056 0.6476
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0478 0.091 0.5577
Echinococcus multilocularis cyclin y 0.0073 0.0033 0.0028
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0042 0.0043
Loa Loa (eye worm) cathepsin B 0.01 0.0093 0.0135
Brugia malayi ORL1-like opioid receptor 0.0494 0.0945 0.1371
Echinococcus granulosus glutamate NMDA receptor subunit 0.0259 0.0436 0.043
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0494 0.0945 0.1106
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0081 0.0051 0.0107
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0063 0.0013 0.0045
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0114 0.0123 0.0729
Onchocerca volvulus 0.0187 0.0281 0.2051
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Echinococcus multilocularis integrin alpha ps 0.0345 0.0623 0.0618
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0494 0.0945 0.1371
Echinococcus granulosus ubiquitin specific protease 41 0.0076 0.0042 0.0036
Echinococcus multilocularis neuropeptide receptor A26 0.0959 0.195 0.1946
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0263 0.0446 0.2712
Echinococcus multilocularis cyclin k 0.0073 0.0033 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0326 0.0581 0.3548
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0073 0.0033 0.0468
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0147 0.0194 0.0281
Brugia malayi Cyclin, N-terminal domain containing protein 0.0073 0.0033 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0494 0.0945 0.094
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0649 0.128 0.7855
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0228 0.037 0.2246
Echinococcus multilocularis calpain A 0.0271 0.0463 0.0457
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0254 0.0426 0.2595
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0063 0.0013 0.0184
Leishmania major hypothetical protein, conserved 0.0263 0.0446 0.2715
Loa Loa (eye worm) hypothetical protein 0.0077 0.0042 0.0061
Leishmania major cathepsin L-like protease 0.0187 0.0281 0.17
Echinococcus multilocularis neuropeptide receptor 0.126 0.2603 0.2598
Trichomonas vaginalis cyclin B3, putative 0.0073 0.0033 0.0066
Echinococcus multilocularis axis inhibition protein axin 0.0081 0.0051 0.0045
Loa Loa (eye worm) hypothetical protein 0.0187 0.0281 0.0408
Loa Loa (eye worm) hypothetical protein 0.0417 0.0777 0.1127
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0587 0.1147 0.7035
Brugia malayi Papain family cysteine protease containing protein 0.0099 0.0091 0.0132
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0076 0.0042 0.006
Entamoeba histolytica cyclin C, putative 0.0073 0.0033 0.0275
Echinococcus multilocularis G protein coupled receptor 139 0.126 0.2603 0.2598
Echinococcus multilocularis inhibitor of apoptosis protein 0.016 0.0222 0.0216
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0081 0.0051 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0152 0.0348
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0494 0.0945 0.1106
Brugia malayi PAS domain containing protein 0.0096 0.0084 0.0121
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Loa Loa (eye worm) hypothetical protein 0.0494 0.0945 0.1371
Trypanosoma cruzi mitotic cyclin, putative 0.0073 0.0033 0.0174
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0665 0.1315 0.3126
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0147 0.0194 0.0449

Activities

Activity type Activity value Assay description Source Reference
CIC95 (functional) = 250 nM Antiviral activity against HIV1 NL4-3 in MT4 cells by viral spread assay ChEMBL. 17692518
CIC95 (functional) = 500 nM Antiviral activity against HIV1 with protease K60C mutant in HeLa cells by viral spread assay ChEMBL. 17692518
CIC95 (functional) = 1000 nM Antiviral activity against HIV1 with protease V18C mutant in HeLa cells by viral spread assay ChEMBL. 17692518
IC50 (binding) = 0.2 nM Inhibition of wild type HIV1 NL4-3 protease ChEMBL. 17692518
IC50 (binding) = 0.2 nM Inhibition of wild type HIV1 NL4-3 protease ChEMBL. 17692518
IC50 (binding) = 1.5 nM Inhibition of HIV1 NL4-3 protease K60C mutant ChEMBL. 17692518
IC50 (binding) = 3.2 nM Inhibition of HIV1 NL4-3 protease V18C mutant ChEMBL. 17692518

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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