Detailed information for compound 591119

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 588.42 | Formula: C26H30Cl4N4OS
  • H donors: 3 H acceptors: 1 LogP: 7.1 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)NC(=S)Nc1ccc(c(c1)Cl)Cl
  • InChi: 1S/C26H30Cl4N4OS/c27-21-7-4-18(16-23(21)29)5-9-25(35)31-12-2-1-3-13-34-14-10-19(11-15-34)32-26(36)33-20-6-8-22(28)24(30)17-20/h4-9,16-17,19H,1-3,10-15H2,(H,31,35)(H2,32,33,36)/b9-5+
  • InChiKey: KXCVXJJWJDZVEA-WEVVVXLNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0061 0.0062 0.0068
Echinococcus multilocularis g protein coupled receptor 0.0274 0.0383 0.0422
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0061 0.0062 0.1332
Onchocerca volvulus 0.0087 0.0101 0.0151
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0083 0.0096 0.1073
Echinococcus granulosus serotonin transporter 0.0186 0.0251 0.0277
Echinococcus granulosus histone acetyltransferase KAT2B 0.015 0.0196 0.0216
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0274 0.0383 0.0422
Echinococcus granulosus rhodopsin orphan GPCR 0.0274 0.0383 0.0422
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0071 0.0077 0.0085
Echinococcus granulosus tm gpcr rhodopsin 0.6027 0.9083 1
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0062 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0274 0.0383 0.0422
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0006 0.001
Schistosoma mansoni neurotransmitter gated ion channel 0.0023 0.0005 0.0007
Echinococcus granulosus Mastin 0.0021 0.0001 0.0002
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0022 0.0003 0.0003
Loa Loa (eye worm) inositol-1 0.0039 0.0028 0.0028
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0006 0.001
Onchocerca volvulus 0.0024 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0043 0.0034 0.0034
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1291 0.1922 0.2923
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0075 0.0083 0.5717
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0028 0.0313
Brugia malayi sulfakinin receptor protein 0.0274 0.0383 0.0383
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.0003 0.0004
Brugia malayi cytosol aminopeptidase 0.0022 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0026 0.0009 0.0014
Trypanosoma brucei unspecified product 0.0061 0.0062 0.0058
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0298 0.0421 1
Schistosoma mansoni biogenic amine receptor 0.0274 0.0383 0.0583
Echinococcus granulosus fmrfamide receptor 0.0274 0.0383 0.0422
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0006 0.0006
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0043 0.0034 0.0052
Loa Loa (eye worm) oxidoreductase 0.0024 0.0006 0.0006
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0016 0.0685
Leishmania major hypothetical protein, conserved 0.0075 0.0083 0.0079
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0154 0.0203 0.0309
Schistosoma mansoni polycystin 1-related 0.0124 0.0157 0.0239
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0006 0.0006
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0006 0.0003
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0274 0.0383 0.0422
Echinococcus multilocularis lipoxygenase domain containing protein 0.0124 0.0157 0.0173
Echinococcus multilocularis G protein coupled receptor 139 0.0274 0.0383 0.0422
Schistosoma mansoni DNA polymerase eta 0.0061 0.0062 0.0094
Loa Loa (eye worm) hypothetical protein 0.0032 0.0017 0.0017
Entamoeba histolytica hypothetical protein, conserved 0.0024 0.0006 0.0073
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Mycobacterium ulcerans ketoacyl reductase 0.0024 0.0006 0.006
Brugia malayi jmjC domain containing protein 0.0075 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0274 0.0383 0.0422
Loa Loa (eye worm) neuropeptide F receptor 0.0274 0.0383 0.0383
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0006 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0062 0.0058
Schistosoma mansoni alpha-glucosidase 0.0293 0.0413 0.0628
Schistosoma mansoni sodium/chloride dependent transporter 0.0032 0.0017 0.0027
Onchocerca volvulus 0.0024 0.0006 0.0008
Trypanosoma brucei C-8 sterol isomerase, putative 0.6633 1 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0043 0.0034 0.0038
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0193 0.0262 0.3101
Mycobacterium ulcerans short-chain dehydrogenase 0.0024 0.0006 0.006
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0028 0.0031
Loa Loa (eye worm) hypothetical protein 0.0075 0.0083 0.0083
Leishmania major quinonoid dihydropteridine reductase 0.0024 0.0006 0.0003
Loa Loa (eye worm) trypsin family protein 0.0021 0.0001 0.0001
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0066 0.1432
Echinococcus granulosus sodium and chloride dependent glycine 0.0032 0.0017 0.0019
Echinococcus granulosus lysine specific demethylase 6a 0.0075 0.0083 0.0091
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Onchocerca volvulus Alhambra homolog 0.003 0.0016 0.0021
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.005 0.0047
Loa Loa (eye worm) hypothetical protein 0.0124 0.0157 0.0157
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0006 0.001
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0043 0.0034 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0072 0.0069
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0066 0.0767
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0006 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0084 0.008
Onchocerca volvulus 0.0124 0.0157 0.0237
Brugia malayi hypothetical protein 0.0274 0.0383 0.0383
Trichomonas vaginalis steroid dehydrogenase, putative 0.0024 0.0006 0.0073
Brugia malayi jmjC domain containing protein 0.0075 0.0083 0.0083
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0006 0.0006
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0006 0.001
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0022 0.0003 0.0003
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0112 0.014 0.8825
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0001 0.0002
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0028 0.0043
Echinococcus multilocularis neuropeptides capa receptor 0.0274 0.0383 0.0422
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0032 0.0017 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0274 0.0383 0.0583
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0076 0.0085 0.0094
Onchocerca volvulus 0.0274 0.0383 0.0581
Mycobacterium ulcerans dehydrogenase 0.0024 0.0006 0.006
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0274 0.0383 0.0422
Brugia malayi Tachykinin-like peptides receptor 99D 0.0274 0.0383 0.0383
Plasmodium falciparum amino acid transporter, putative 0.0032 0.0017 0.0728
Leishmania major alpha glucosidase II subunit, putative 0.0076 0.0084 0.008
Brugia malayi jmjC domain containing protein 0.0343 0.0488 0.0488
Loa Loa (eye worm) oxidoreductase 0.0024 0.0006 0.0006
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0112 0.014 1
Schistosoma mansoni hypothetical protein 0.0274 0.0383 0.0583
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0006 0.006
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0006 0.0073
Echinococcus multilocularis glycine receptor subunit beta 0.0043 0.0034 0.0038
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0006 0.001
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0006 0.006
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0021 0.0001 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0062 0.0058
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0071 0.0077 0.0077
Leishmania major quinonoid dihydropteridine reductase 0.0024 0.0006 0.0003
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0006 0.001
Schistosoma mansoni leucine aminopeptidase 0.0022 0.0003 0.0005
Echinococcus granulosus hypothetical protein 0.524 0.7894 0.8691
Plasmodium falciparum cysteine repeat modular protein 1 0.0026 0.0009 0.0179
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0028 0.0313
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0001 0.0002
Echinococcus multilocularis neuropeptide receptor 0.0274 0.0383 0.0422
Echinococcus multilocularis lysosomal alpha glucosidase 0.0341 0.0485 0.0534
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0001 0.0002
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Echinococcus granulosus rhodopsin orphan GPCR 0.0274 0.0383 0.0422
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0006 0.0006
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0007 0.0001
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0066 0.0073
Onchocerca volvulus 0.0024 0.0006 0.0008
Mycobacterium ulcerans short-chain dehydrogenase 0.0024 0.0006 0.006
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Echinococcus multilocularis fmrfamide receptor 0.0274 0.0383 0.0422
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0006 0.006
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0043 0.0034 0.0038
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0022 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0637 0.0933 0.0933
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0028 0.1628
Trypanosoma cruzi short chain dehydrogenase, putative 0.0024 0.0006 0.0003
Brugia malayi G-protein coupled receptor 0.0274 0.0383 0.0383
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0072 0.0069
Schistosoma mansoni protein phosphatase 2C 0.0075 0.0083 0.0126
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0218 0.03 0.03
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0112 0.014 0.3211
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0274 0.0383 0.0422
Echinococcus multilocularis neuropeptide Y receptor 0.0274 0.0383 0.0422
Brugia malayi G protein-coupled receptor F59B2.13 0.0274 0.0383 0.0383
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0006 0.001
Leishmania major cathepsin L-like protease 0.0068 0.0072 0.0069
Echinococcus granulosus biogenic amine 5HT receptor 0.2889 0.4338 0.4776
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0005
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0043 0.0034 0.0038
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0006
Brugia malayi hypothetical protein 0.0124 0.0157 0.0157
Schistosoma mansoni hypothetical protein 0.0124 0.0157 0.0239
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0169 0.0225 0.0225
Leishmania major quinonoid dihydropteridine reductase 0.0024 0.0006 0.0003
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0022 0.0003 0.0004
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0274 0.0383 0.0422
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Schistosoma mansoni biogenic amine receptor 0.0274 0.0383 0.0583
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0072 0.0069
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0024 0.0006 0.0008
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0021 0.0001 0.0001
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0066 0.4459
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.4369 0.6576 0.6576
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0043 0.0034 0.0034
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0298 0.0421 0.4997
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0072 0.0069
Echinococcus granulosus rhodopsin orphan GPCR 0.0274 0.0383 0.0422
Echinococcus multilocularis phd:f box containing protein 0.0075 0.0083 0.0091
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Echinococcus granulosus g protein coupled receptor 0.0274 0.0383 0.0422
Loa Loa (eye worm) hypothetical protein 0.0032 0.0017 0.0017
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Schistosoma mansoni amine GPCR 0.0274 0.0383 0.0583
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0005
Echinococcus multilocularis serotonin receptor 0.0693 0.1017 0.112
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0006 0.006
Loa Loa (eye worm) hypothetical protein 0.0032 0.0017 0.0017
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0066 0.0073
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.0003 0.0004
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0193 0.0262 0.0258
Schistosoma mansoni opsin-like receptor 0.0274 0.0383 0.0583
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0024 0.0006 0.0008
Echinococcus granulosus biogenic amine 5HT receptor 0.0693 0.1017 0.112
Echinococcus multilocularis peregrin 0.0034 0.0021 0.0023
Onchocerca volvulus 0.0043 0.0034 0.005
Onchocerca volvulus 0.0032 0.0017 0.0024
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0274 0.0383 0.0383
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0024 0.0006 0.0007
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Brugia malayi hypothetical protein 0.0032 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0028 0.0313
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0006 0.001
Leishmania major short chain dehydrogenase-like protein 0.0024 0.0006 0.0003
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0043 0.0034 0.0038
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0017 0.0728
Schistosoma mansoni cpg binding protein 0.0032 0.0019 0.0028
Onchocerca volvulus 0.0274 0.0383 0.0581
Brugia malayi hypothetical protein 0.0274 0.0383 0.0383
Trypanosoma brucei glycosyl hydrolase-like protein 0.0028 0.0012 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0611 0.0894 1
Toxoplasma gondii kringle domain-containing protein 0.0026 0.0009 0.0202
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0043 0.0034 0.0034
Brugia malayi Melatonin receptor type 1A 0.0274 0.0383 0.0383
Echinococcus multilocularis carbonyl reductase 1 0.0024 0.0006 0.0007
Schistosoma mansoni neuropeptide receptor 0.0274 0.0383 0.0583
Schistosoma mansoni phosphatidylserine receptor 0.0075 0.0083 0.0126
Brugia malayi Dopamine receptor 0.0274 0.0383 0.0383
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0274 0.0383 0.0422
Plasmodium vivax hypothetical protein, conserved 0.003 0.0016 0.0605
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0024 0.0006 0.006
Brugia malayi AKH receptor 0.0274 0.0383 0.0383
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0075 0.0083 0.5717
Echinococcus multilocularis rhodopsin orphan GPCR 0.0274 0.0383 0.0422
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0005
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0024 0.0006 0.0073
Schistosoma mansoni sodium/chloride dependent transporter 0.0186 0.0251 0.0382
Echinococcus multilocularis dnaJ subfamily B 0.0436 0.0628 0.0692
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0006 0.0073
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Schistosoma mansoni inositol monophosphatase 0.0039 0.0028 0.0043
Schistosoma mansoni nAChR subunit 0.0043 0.0034 0.0052
Echinococcus granulosus peptide allatostatin:somatostatin 0.0274 0.0383 0.0422
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0274 0.0383 0.0583
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Loa Loa (eye worm) melatonin receptor type 1A 0.0274 0.0383 0.0383
Loa Loa (eye worm) solute carrier family 6 member 4 0.0186 0.0251 0.0251
Brugia malayi hypothetical protein 0.0274 0.0383 0.0383
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0006 0.001
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0341 0.0485 0.0485
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0006 0.001
Brugia malayi excitatory GABA receptor EXP-1A 0.0043 0.0034 0.0034
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0024 0.0006 0.006
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0001 0.0002
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0021 0.0001 0.0002
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0084 0.0939
Loa Loa (eye worm) hypothetical protein 0.0028 0.0012 0.0012
Brugia malayi hypothetical protein 0.0274 0.0383 0.0383
Loa Loa (eye worm) oxidoreductase 0.0024 0.0006 0.0006
Echinococcus granulosus transmembrane protease serine 3 0.0021 0.0001 0.0002
Onchocerca volvulus 0.0274 0.0383 0.0581
Echinococcus granulosus sex peptide receptor 0.0274 0.0383 0.0422
Brugia malayi hypothetical protein 0.0024 0.0006 0.0006
Brugia malayi Trypsin family protein 0.0021 0.0001 0.0001
Echinococcus granulosus neutral alpha glucosidase AB 0.0076 0.0084 0.0092
Echinococcus multilocularis carbonyl reductase 1 0.0024 0.0006 0.0007
Loa Loa (eye worm) ACC-1 protein 0.0043 0.0034 0.0034
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0072 0.0069
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0006 0.0006
Echinococcus granulosus glycine receptor subunit alpha 1 0.0043 0.0034 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0072 0.0069
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0071 0.0108
Echinococcus multilocularis RUN 0.0124 0.0157 0.0173
Schistosoma mansoni sodium-dependent amino acid transporter 0.0032 0.0017 0.0027
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0024 0.0006 0.0006
Brugia malayi Doublecortin family protein 0.0124 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Onchocerca volvulus 0.0031 0.0016 0.0022
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Loa Loa (eye worm) jmjC domain-containing protein 0.0075 0.0083 0.0083
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0112 0.014 0.0136
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0007 0.006
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0024 0.0006 0.0073
Brugia malayi hypothetical protein 0.0274 0.0383 0.0383
Echinococcus multilocularis retinol dehydrogenase 11 0.0024 0.0006 0.0007
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0043 0.0034 0.0034
Echinococcus multilocularis neuropeptide Y receptor 0.0274 0.0383 0.0422
Schistosoma mansoni jumonji domain containing protein 0.0322 0.0457 0.0695
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0066 0.0072
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0001 0.0002
Echinococcus multilocularis neuropeptides capa receptor 0.0274 0.0383 0.0422
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0034 0.0037
Brugia malayi Pre-SET motif family protein 0.044 0.0635 0.0635
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0033 0.003
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0479 0.0693 0.0763
Echinococcus multilocularis rhodopsin orphan GPCR 0.0274 0.0383 0.0422
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0024 0.0006 0.0003
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0007 0.0002
Onchocerca volvulus 0.0274 0.0383 0.0581
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0028 0.0031
Echinococcus multilocularis steroid dehydrogenase 0.0024 0.0006 0.0007
Echinococcus multilocularis carbonyl reductase 1 0.0024 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0033 0.0294
Schistosoma mansoni biogenic amine (5HT) receptor 0.0693 0.1017 0.1546
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0006 0.0006
Loa Loa (eye worm) oxidoreductase 0.0024 0.0006 0.0006
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0061 0.0062 0.0062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0611 0.0894 1
Onchocerca volvulus 0.0024 0.0006 0.0008
Echinococcus multilocularis somatostatin receptor 0.0274 0.0383 0.0422
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0038 0.2388
Leishmania major quinonoid dihydropteridine reductase 0.0024 0.0006 0.0003
Echinococcus multilocularis neuropeptide receptor A26 0.0274 0.0383 0.0422
Schistosoma mansoni nAChR subunit 0.0043 0.0034 0.0052
Trypanosoma brucei short-chain dehydrogenase, putative 0.0024 0.0006 0.0003
Loa Loa (eye worm) norepinephrine transporter 0.0186 0.0251 0.0251
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0043 0.0034 0.0034
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0006 0.001
Onchocerca volvulus 0.0274 0.0383 0.0581
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0072 0.0069
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0028 0.0315
Schistosoma mansoni lipoxygenase 0.0255 0.0356 0.0541
Leishmania major quinonoid dihydropteridine reductase 0.0024 0.0006 0.0003
Schistosoma mansoni amine GPCR 0.0274 0.0383 0.0583
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0162 0.0162
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0006 0.0073
Leishmania major hypothetical protein, conserved 0.0024 0.0006 0.0003
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0043 0.0034 0.0038
Loa Loa (eye worm) hypothetical protein 0.0218 0.03 0.03
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0043 0.0034 0.0038
Echinococcus granulosus dna polymerase kappa 0.0061 0.0062 0.0068
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0071 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.0005 0.0005
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0024 0.0006 0.0003
Brugia malayi Protein kinase domain containing protein 0.0026 0.0009 0.0009
Echinococcus multilocularis steroid dehydrogenase 0.0024 0.0006 0.0007
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0012 0.0137
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0032 0.0017 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0062 0.0058
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Echinococcus granulosus sodium and chloride dependent glycine 0.0032 0.0017 0.0019
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Onchocerca volvulus 0.0043 0.0034 0.005
Echinococcus granulosus lipoxygenase domain containing protein 0.0124 0.0157 0.0173
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0043 0.0034 0.0034
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0012 0.0137
Echinococcus multilocularis sodium and chloride dependent glycine 0.0032 0.0017 0.0019
Echinococcus multilocularis glycine receptor subunit beta 0.0043 0.0034 0.0038
Schistosoma mansoni nAChR subunit 0.0043 0.0034 0.0052
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0043 0.0034 0.0038
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0274 0.0383 0.0422
Echinococcus granulosus rhodopsin orphan GPCR 0.0274 0.0383 0.0422
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0274 0.0383 0.0383
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0028 0.0028
Entamoeba histolytica deoxycytidyl transferase, putative 0.0061 0.0062 0.0691
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0043 0.0034 0.0034
Loa Loa (eye worm) jmjC domain-containing protein 0.0075 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0006
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0298 0.0421 1
Loa Loa (eye worm) TYRA-2 protein 0.0274 0.0383 0.0383
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0007 0.0001
Echinococcus granulosus leucine aminopeptidase protein 0.0112 0.014 0.0154
Brugia malayi CXXC zinc finger family protein 0.0031 0.0016 0.0016
Onchocerca volvulus 0.0043 0.0034 0.005
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0072 0.0069
Leishmania major DNA polymerase eta, putative 0.0061 0.0062 0.0058
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0076 0.0084 0.0939
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0028 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0006 0.0003
Trypanosoma brucei oxidoreductase-like protein 0.0024 0.0006 0.0003
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0043 0.0034 0.0034
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0032 0.0017 0.0027
Echinococcus multilocularis conserved hypothetical protein 0.0024 0.0006 0.0007
Brugia malayi Trypsin family protein 0.0021 0.0001 0.0001
Loa Loa (eye worm) dehydrogenase 0.0024 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0274 0.0383 0.0422
Brugia malayi Trypsin-like protease protein 5 0.0021 0.0001 0.0001
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0218 0.03 0.0456
Trypanosoma brucei short-chain dehydrogenase, putative 0.0024 0.0006 0.0003
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0043 0.0034 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0274 0.0383 0.0583
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0032 0.0017 0.0019
Mycobacterium ulcerans glutaminase 0.0576 0.0841 1
Brugia malayi Serotonin receptor 0.0274 0.0383 0.0383
Echinococcus granulosus glycoprotein Antigen 5 0.0021 0.0001 0.0002
Leishmania major short chain dehydrogenase, putative 0.0024 0.0006 0.0003
Onchocerca volvulus 0.0032 0.0017 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0072 0.0069
Onchocerca volvulus Putative nachr subunit 0.0043 0.0034 0.005
Brugia malayi G protein-coupled receptor 0.0274 0.0383 0.0383
Echinococcus granulosus rhodopsin orphan GPCR 0.0274 0.0383 0.0422
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0001 0.0002
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0006 0.001
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0006 0.001
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.0101 0.0111
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0084 0.0939
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0066 0.0073
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0005
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0043 0.0034 0.0034
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0043 0.0034 0.0038
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Brugia malayi glutaminase DH11.1 0.0576 0.0841 0.0841
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0274 0.0383 0.0583
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0062 0.0058
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0022 0.0375
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0043 0.0034 0.0034
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0028 0.0315
Loa Loa (eye worm) hypothetical protein 0.0075 0.0083 0.0083
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0611 0.0894 1
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0062 0.0058
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0274 0.0383 0.0581
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Leishmania major C-8 sterol isomerase-like protein 0.6633 1 1
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0024 0.0006 0.0006
Echinococcus multilocularis vesicular acetylcholine transporter 0.4369 0.6576 0.7241
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0032 0.0017 0.0017
Brugia malayi Kringle domain containing protein 0.0026 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Echinococcus multilocularis dna polymerase eta 0.0061 0.0062 0.0068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0274 0.0383 0.0583
Echinococcus granulosus neuropeptide Y receptor 0.0274 0.0383 0.0422
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0007 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0066 0.01
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0024 0.0006 0.0073
Brugia malayi follicle stimulating hormone receptor 0.0274 0.0383 0.0383
Trypanosoma cruzi DNA polymerase eta, putative 0.0061 0.0062 0.0058
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0005
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0012 0.0137
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0024 0.0006 0.006
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0072 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0072 0.0069
Echinococcus multilocularis retinol dehydrogenase 11 0.0024 0.0006 0.0007
Schistosoma mansoni loxhd1 0.0124 0.0157 0.0239
Onchocerca volvulus 0.0197 0.0268 0.0406
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Brugia malayi Dehydrogenases, short chain protein 2 0.0024 0.0006 0.0006
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0274 0.0383 0.0583
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0006 0.001
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0193 0.0262 0.3101
Echinococcus granulosus tm gpcr rhodopsin 0.0274 0.0383 0.0422
Echinococcus multilocularis sodium and chloride dependent glycine 0.0032 0.0017 0.0019
Brugia malayi hypothetical protein 0.0021 0.0001 0.0001
Schistosoma mansoni voltage-gated potassium channel 0.0078 0.0087 0.0132
Echinococcus granulosus voltage gated potassium channel 0.0021 0.0001 0.0001
Schistosoma mansoni neuropeptide f receptor 76f 0.0274 0.0383 0.0583
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0072 0.0069
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0076 0.0084 0.0939
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.0062 0.0718
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0274 0.0383 0.0422
Echinococcus granulosus jumonji domain containing 1A 0.0075 0.0083 0.0091
Plasmodium vivax JmjC domain containing protein 0.0075 0.0083 0.5045
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0066 0.007 0.0783
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0193 0.0262 0.0398
Echinococcus multilocularis neuropeptide FF receptor 2 0.0274 0.0383 0.0422
Echinococcus granulosus WW domain containing oxidoreductase 0.0024 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0274 0.0383 0.0422
Mycobacterium ulcerans leucyl aminopeptidase 0.0112 0.014 0.1645
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0024 0.0006 0.0003
Echinococcus granulosus dna polymerase eta 0.0061 0.0062 0.0068
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0611 0.0894 1
Toxoplasma gondii hypothetical protein 0.0032 0.0017 0.0824
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0112 0.014 0.0136
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0611 0.0894 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0024 0.0006 0.0008
Trypanosoma brucei short-chain dehydrogenase, putative 0.0024 0.0006 0.0003
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0021 0.0001 0.0002
Schistosoma mansoni amine GPCR 0.1042 0.1545 0.2349
Echinococcus granulosus alpha 1A adrenergic receptor 0.0274 0.0383 0.0422
Echinococcus granulosus allatostatin A receptor 0.0274 0.0383 0.0422
Loa Loa (eye worm) hypothetical protein 0.339 0.5096 0.5096
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0006 0.0006
Brugia malayi dehydrogenases, short chain protein 2 0.0024 0.0006 0.0006
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.0012 0.0137
Trypanosoma brucei unspecified product 0.0042 0.0033 0.003
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0043 0.0034 0.0038
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0032 0.0017 0.0824
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0274 0.0383 0.0383
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.0101 0.0111
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0028 0.0025
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0193 0.0262 0.0288
Schistosoma mansoni alpha glucosidase 0.0076 0.0084 0.0128
Brugia malayi hypothetical protein 0.0274 0.0383 0.0383
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0066 0.01
Giardia lamblia Fructose-bisphosphate aldolase 0.0611 0.0894 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0341 0.0485 0.0485
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.0062 0.0718
Loa Loa (eye worm) oxidoreductase 0.0024 0.0006 0.0006
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0024 0.0006 0.0073
Onchocerca volvulus Sepiapterin reductase homolog 0.0024 0.0006 0.0008
Schistosoma mansoni rab6-interacting 0.0124 0.0157 0.0239
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0274 0.0383 0.0583
Onchocerca volvulus 0.0024 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0186 0.0251 0.0251
Echinococcus granulosus JmjC domain containing protein 4 0.0075 0.0083 0.0091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0066 0.01
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0006
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0075 0.0083 0.0126
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0274 0.0383 0.0583
Loa Loa (eye worm) TK/ROR protein kinase 0.0026 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.0016 0.0016
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0026 0.0009 0.0179
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0043 0.0034 0.0034
Onchocerca volvulus 0.0024 0.0006 0.0008
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0043 0.0034 0.0034
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0024 0.0006 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0024 0.0006 0.0003
Echinococcus multilocularis transmembrane protease serine 3 0.0021 0.0001 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0062 0.0058
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0024 0.0006 0.0007
Leishmania major short chain dehydrogenase/reductase, putative 0.0024 0.0006 0.0003
Entamoeba histolytica short chain dehydrogenase family protein 0.0024 0.0006 0.0073
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0003 0.0004
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.0012 0.0012
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0032 0.0017 0.0027
Echinococcus multilocularis biogenic amine (5HT) receptor 0.2889 0.4338 0.4776
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0005
Mycobacterium ulcerans carveol-like dehydrogenase 0.0024 0.0006 0.006
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0066 0.0062
Echinococcus granulosus neuropeptides capa receptor 0.0274 0.0383 0.0422
Onchocerca volvulus 0.0024 0.0006 0.0008
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Onchocerca volvulus 0.0274 0.0383 0.0581
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Echinococcus multilocularis oxidoreductase 0.0024 0.0006 0.0007
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0043 0.0034 0.0052
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0274 0.0383 0.0422
Treponema pallidum sodium- and chloride- dependent transporter 0.0186 0.0251 0.276
Loa Loa (eye worm) hypothetical protein 0.1291 0.1922 0.1922
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0611 0.0894 1
Echinococcus granulosus retinol dehydrogenase 11 0.0024 0.0006 0.0007
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0024 0.0006 0.0003
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0016 0.0017
Echinococcus multilocularis g protein coupled receptor 0.0274 0.0383 0.0422
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0033 0.0364
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0021 0.0001 0.0002
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Onchocerca volvulus 0.0274 0.0383 0.0581
Onchocerca volvulus 0.0274 0.0383 0.0581
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0193 0.0262 0.6159
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Leishmania major cathepsin L-like protease 0.0068 0.0072 0.0069
Schistosoma mansoni hypothetical protein 0.0274 0.0383 0.0583
Onchocerca volvulus 0.0043 0.0034 0.005
Echinococcus granulosus lysine specific demethylase 5A 0.0282 0.0396 0.0436
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0005
Onchocerca volvulus 0.0274 0.0383 0.0581
Brugia malayi oxidoreductase 0.0024 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0186 0.0251 0.0251
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0006 0.001
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0611 0.0894 1
Trichomonas vaginalis set domain proteins, putative 0.0501 0.0727 0.814
Schistosoma mansoni vesicular acetylcholine transporter 0.4369 0.6576 1
Brugia malayi acetyltransferase, GNAT family protein 0.0154 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0064 0.0066 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0274 0.0383 0.0583
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Loa Loa (eye worm) hypothetical protein 0.0039 0.0028 0.0028
Leishmania major oxidoreductase-like protein 0.0024 0.0006 0.0003
Echinococcus multilocularis serotonin receptor 0.0693 0.1017 0.112
Echinococcus multilocularis conserved hypothetical protein 0.4967 0.748 0.8235
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0083 0.0096 0.1073
Echinococcus multilocularis retinol dehydrogenase 13 0.0024 0.0006 0.0007
Loa Loa (eye worm) acetyltransferase 0.0154 0.0203 0.0203
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0274 0.0383 0.0422
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0061 0.0062 0.0094
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0066 0.01
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Mycobacterium ulcerans ketoacyl reductase 0.0024 0.0006 0.006
Brugia malayi PHD-finger family protein 0.003 0.0016 0.0016
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0006 0.001
Onchocerca volvulus 0.0024 0.0006 0.0008
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0024 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0124 0.0157 0.0157
Brugia malayi Pre-SET motif family protein 0.0064 0.0066 0.0066
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0012 0.0009
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0007 0.006
Schistosoma mansoni nAChR subunit 0.0043 0.0034 0.0052
Loa Loa (eye worm) jmjC domain-containing protein 0.0075 0.0083 0.0083
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0274 0.0383 0.0383
Mycobacterium tuberculosis Conserved hypothetical protein 0.0061 0.0062 0.1332
Loa Loa (eye worm) oxidoreductase 0.0024 0.0006 0.0006
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0274 0.0383 0.0422
Echinococcus granulosus tm gpcr rhodopsin 0.0274 0.0383 0.0422
Echinococcus granulosus rhodopsin orphan GPCR 0.0274 0.0383 0.0422
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0024 0.0006 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0274 0.0383 0.0422
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0016 0.0685
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0032 0.0017 0.0027
Echinococcus granulosus G protein coupled receptor 139 0.0274 0.0383 0.0422
Echinococcus granulosus lipoxygenase domain containing protein 0.0124 0.0157 0.0173
Brugia malayi Cation transporter family protein 0.0043 0.0034 0.0034
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0043 0.0034 0.0034
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0024 0.0006 0.0003
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0024 0.0006 0.0003
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0028 0.0024
Echinococcus granulosus neuropeptide receptor 0.0274 0.0383 0.0422
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0024 0.0006 0.0007
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0006 0.0006
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0274 0.0383 0.0583
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0024 0.0006 0.0007
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0043 0.0034 0.0038
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0006 0.0006
Onchocerca volvulus 0.0043 0.0034 0.005
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0028 0.0024
Loa Loa (eye worm) hypothetical protein 0.0083 0.0096 0.0096
Onchocerca volvulus 0.0274 0.0383 0.0581
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0043 0.0034 0.0038
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0062 0.0058
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Onchocerca volvulus 0.0024 0.0006 0.0008
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0076 0.0085 0.0094
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0038 0.0428
Echinococcus multilocularis nAChR subunit 0.0023 0.0005 0.0005
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0024 0.0006 0.0003
Brugia malayi hypothetical protein 0.0274 0.0383 0.0383
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0003 0.0004
Leishmania major quinonoid dihydropteridine reductase 0.0024 0.0006 0.0003
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0611 0.0894 1
Echinococcus multilocularis serotonin transporter 0.0186 0.0251 0.0277
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0006 0.0073
Schistosoma mansoni carbonyl reductase 0.0024 0.0006 0.001
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0007 0.0003
Brugia malayi vesicular acetylcholine transporter unc-17 0.4369 0.6576 0.6576
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0063 0.006
Schistosoma mansoni neuropeptide F-like receptor 0.0274 0.0383 0.0583
Schistosoma mansoni amine GPCR 0.0274 0.0383 0.0583
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0066 0.007 0.0783
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0028 0.0315
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0274 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0693 0.1017 0.1017
Schistosoma mansoni lipoxygenase 0.0479 0.0693 0.1054
Plasmodium falciparum JmjC domain-containing protein, putative 0.0075 0.0083 0.5045
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0006 0.0003
Leishmania major glycosyl hydrolase-like protein 0.0028 0.0012 0.0009
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0024 0.0006 0.0073
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0024 0.0006 0.001
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0028 0.0043
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0274 0.0383 0.0583
Leishmania major hypothetical protein, conserved 0.0024 0.0006 0.0003
Echinococcus granulosus serotonin receptor 0.0274 0.0383 0.0422
Leishmania major cathepsin L-like protease 0.0068 0.0072 0.0069
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0274 0.0383 0.0383
Schistosoma mansoni sodium/chloride dependent transporter 0.0032 0.0017 0.0027
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0061 0.0068
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0024 0.0006 0.0003
Onchocerca volvulus 0.0274 0.0383 0.0581
Brugia malayi Inositol-1 0.0039 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0023 0.0005 0.0005
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0274 0.0383 0.0422
Brugia malayi Cation transporter family protein 0.0043 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0043 0.0034 0.0052
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0274 0.0383 0.0583
Treponema pallidum fructose-bisphosphate aldolase 0.0611 0.0894 1
Entamoeba histolytica hypothetical protein 0.0024 0.0006 0.0073
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0479 0.0693 0.0763
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0006
Echinococcus granulosus carbonyl reductase 1 0.0024 0.0006 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0033 0.003
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0028 0.0315
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0024 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Echinococcus granulosus vesicular acetylcholine transporter 0.4369 0.6576 0.7241
Brugia malayi Dopamine receptor protein 2 0.0274 0.0383 0.0383
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0066 0.4472
Trypanosoma brucei unspecified product 0.0042 0.0033 0.003
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0006 0.0073
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0032 0.0017 0.0824
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0075 0.0083 0.0079
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0043 0.0034 0.0038
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0006 0.001
Schistosoma mansoni hypothetical protein 0.0274 0.0383 0.0583
Loa Loa (eye worm) LGC-31 protein 0.0043 0.0034 0.0034
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0022 0.0003 0.0003
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0034 0.0037
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0043 0.0034 0.0038
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0032 0.0017 0.0027
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0084 0.0939
Schistosoma mansoni neuropeptide receptor 0.0274 0.0383 0.0583
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0028 0.0031
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0023 0.0005 0.0005
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0043 0.0034 0.0052
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0001 0.0002
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0024 0.0006 0.006
Echinococcus granulosus dro:myosuppressin receptor 0.0274 0.0383 0.0422
Schistosoma mansoni hypothetical protein 0.0436 0.0628 0.0955
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0021 0.0001 0.0001
Brugia malayi ImpB/MucB/SamB family protein 0.0061 0.0062 0.0062
Echinococcus multilocularis G-protein coupled receptor, putative 0.0274 0.0383 0.0422
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0024 0.0006 0.001
Loa Loa (eye worm) glutaminase 0.0576 0.0841 0.0841
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0193 0.0262 0.0262
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0274 0.0383 0.0583
Schistosoma mansoni biogenic amine (5HT) receptor 0.2889 0.4338 0.6596
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0028 0.0031
Echinococcus granulosus neuropeptides capa receptor 0.0274 0.0383 0.0422
Brugia malayi hypothetical protein 0.0274 0.0383 0.0383
Mycobacterium ulcerans dehydrogenase/reductase 0.0024 0.0006 0.006
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0032 0.0017 0.0017
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0006 0.001
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0028 0.0024
Echinococcus multilocularis enteropeptidase 0.0021 0.0001 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0065 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0033 0.003
Echinococcus granulosus g protein coupled receptor 0.0274 0.0383 0.0422
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.044 0.0635 0.0635
Echinococcus granulosus orexin receptor type 2 0.0274 0.0383 0.0422
Schistosoma mansoni hypothetical protein 0.0021 0.0001 0.0002
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0162 0.0162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0072 0.0069
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0066 0.4507
Onchocerca volvulus 0.0024 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Schistosoma mansoni retinal dehydrogenase 0.0024 0.0006 0.001
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0001 0.0002
Onchocerca volvulus 0.0024 0.0006 0.0008
Brugia malayi G-protein coupled receptor 0.0274 0.0383 0.0383
Echinococcus multilocularis Mastin 0.0021 0.0001 0.0002
Echinococcus granulosus g-protein coupled receptor 0.0274 0.0383 0.0422
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0016 0.0017
Schistosoma mansoni neuropeptide receptor 0.0274 0.0383 0.0583
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0611 0.0894 1
Echinococcus multilocularis leucine aminopeptidase protein 0.0112 0.014 0.0154
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0032 0.0017 0.0824
Onchocerca volvulus 0.0023 0.0005 0.0005
Echinococcus multilocularis lipoxygenase domain containing protein 0.0124 0.0157 0.0173
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0006 0.0073
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0001 0.0002
Echinococcus multilocularis transient receptor potential cation channel 0.0024 0.0006 0.0007
Echinococcus granulosus 7TM GPCR rhodopsin 0.0274 0.0383 0.0422
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0023 0.0005 0.0007
Schistosoma mansoni terminal deoxycytidyl transferase 0.0061 0.0062 0.0094
Schistosoma mansoni cpg binding protein 0.0031 0.0016 0.0024
Chlamydia trachomatis cytosol aminopeptidase 0.0112 0.014 1
Trichomonas vaginalis glutaminase, putative 0.0576 0.0841 0.9411
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.0101 0.0153
Entamoeba histolytica hypothetical protein, conserved 0.0024 0.0006 0.0073
Onchocerca volvulus 0.0026 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0006
Echinococcus multilocularis sex peptide receptor 0.0274 0.0383 0.0422
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0062 0.0058
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0016 0.0016
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0028 0.0031
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0071 0.0077 0.0085
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0032 0.0017 0.0019
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0006
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0038 0.0042
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Echinococcus granulosus oxidoreductase 0.0024 0.0006 0.0007
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0006 0.006
Schistosoma mansoni carbonyl reductase 0.0024 0.0006 0.001
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0043 0.0034 0.0052
Brugia malayi hypothetical protein 0.0124 0.0157 0.0157
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0043 0.0034 0.0038
Loa Loa (eye worm) jmjC domain-containing protein 0.0282 0.0396 0.0396
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.0012 0.0137
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0066 0.01
Brugia malayi neuropeptide F receptor 0.0274 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0693 0.1017 0.1017
Toxoplasma gondii leucyl aminopeptidase LAP 0.0112 0.014 1
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Echinococcus multilocularis expressed protein 0.0391 0.0561 0.0618
Onchocerca volvulus 0.0024 0.0006 0.0008
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0028 0.0313
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Echinococcus multilocularis glycoprotein Antigen 5 0.0021 0.0001 0.0002
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0032 0.0017 0.0823
Echinococcus granulosus carbonyl reductase 1 0.0024 0.0006 0.0007
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0043 0.0034 0.0034
Echinococcus granulosus carbonyl reductase 1 0.0024 0.0006 0.0007
Loa Loa (eye worm) oxidoreductase 0.0024 0.0006 0.0006
Brugia malayi hypothetical protein 0.0274 0.0383 0.0383
Onchocerca volvulus 0.0124 0.0157 0.0237
Schistosoma mansoni biogenic amine receptor 0.0274 0.0383 0.0583
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0006 0.001
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0006 0.0006
Echinococcus granulosus 7tm_1 domain containing protein 0.0274 0.0383 0.0422
Schistosoma mansoni nAChR subunit 0.0043 0.0034 0.0052
Loa Loa (eye worm) GABA receptor subunit 0.0023 0.0005 0.0005
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0218 0.03 0.0456
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0006
Echinococcus multilocularis lysosomal alpha glucosidase 0.0341 0.0485 0.0534
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0032 0.0017 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0062 0.0058
Giardia lamblia DINP protein human, muc B family 0.0061 0.0062 0.0623
Mycobacterium ulcerans short-chain dehydrogenase 0.0024 0.0006 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0062 0.0058
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0076 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Echinococcus multilocularis dna polymerase kappa 0.0061 0.0062 0.0068
Loa Loa (eye worm) oxidoreductase 0.0024 0.0006 0.0006
Echinococcus multilocularis neutral alpha glucosidase AB 0.0076 0.0084 0.0092
Echinococcus granulosus somatostatin receptor 0.0274 0.0383 0.0422
Echinococcus multilocularis nAChR subunit 0.0043 0.0034 0.0038
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0028 0.0031
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0016 0.0016
Loa Loa (eye worm) G-protein coupled receptor 0.0274 0.0383 0.0383
Echinococcus granulosus rhodopsin orphan GPCR 0.0274 0.0383 0.0422
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0043 0.0034 0.0038
Echinococcus granulosus tissue type plasminogen activator 0.0026 0.0009 0.001
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0001 0.0002
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0024 0.0006 0.0003
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0006 0.0006
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0061 0.0062 0.0068
Plasmodium falciparum LCCL domain-containing protein 0.0124 0.0157 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0274 0.0383 0.0583
Loa Loa (eye worm) hypothetical protein 0.0186 0.0251 0.0251
Schistosoma mansoni alpha-1 adrenergic receptor 0.0274 0.0383 0.0583
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0006 0.001
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0033 0.1728
Loa Loa (eye worm) hypothetical protein 0.6633 1 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0075 0.0083 0.0091
Echinococcus granulosus neuropeptide s receptor 0.0274 0.0383 0.0422
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0001 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0066 0.01
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0084 0.0939
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Loa Loa (eye worm) G-protein coupled receptor 0.0274 0.0383 0.0383
Echinococcus multilocularis tissue type plasminogen activator 0.0026 0.0009 0.001
Giardia lamblia PHD finger protein 15 0.003 0.0016 0.0103
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0026 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0274 0.0383 0.0422
Echinococcus multilocularis rhodopsin orphan GPCR 0.0274 0.0383 0.0422
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0043 0.0034 0.0038
Onchocerca volvulus 0.0023 0.0005 0.0005
Echinococcus multilocularis allatostatin A receptor 0.0274 0.0383 0.0422
Schistosoma mansoni nAChR subunit 0.0043 0.0034 0.0052
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0007 0.0002
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0061 0.0062 0.0691
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0043 0.0034 0.0034
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0038 0.2107
Plasmodium vivax amine transporter, putative 0.0032 0.0017 0.0728
Brugia malayi Retinol dehydrogenase 12 0.0024 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0032 0.0017 0.0017
Echinococcus granulosus expressed protein 0.0391 0.0561 0.0618
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0021 0.0001 0.0001
Schistosoma mansoni neuropeptide receptor 0.0274 0.0383 0.0583
Echinococcus multilocularis neuropeptide receptor 0.0274 0.0383 0.0422
Echinococcus granulosus glycine receptor subunit alpha 1 0.0043 0.0034 0.0038
Onchocerca volvulus 0.0274 0.0383 0.0581
Loa Loa (eye worm) hypothetical protein 0.1291 0.1922 0.1922
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Onchocerca volvulus 0.0064 0.0066 0.0098
Mycobacterium ulcerans oxidoreductase 0.0024 0.0006 0.006
Entamoeba histolytica hypothetical protein 0.0023 0.0005 0.0051
Echinococcus granulosus RUN 0.0124 0.0157 0.0173
Leishmania major hypothetical protein, conserved 0.0026 0.0009 0.0006
Brugia malayi RE15519p 0.0274 0.0383 0.0383
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0072 0.0069
Echinococcus multilocularis rhodopsin orphan GPCR 0.0274 0.0383 0.0422
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0084 0.008
Leishmania major dehydrogenase-like protein 0.0024 0.0006 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0611 0.0894 1
Plasmodium vivax SET domain protein, putative 0.0064 0.0066 0.3947
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0006 0.006
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.6027 0.9083 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0022 0.0375
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Brugia malayi larval opioid receptor 0.0274 0.0383 0.0383
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0028 0.0025
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0024 0.0006 0.0073
Onchocerca volvulus 0.0197 0.0268 0.0405
Schistosoma mansoni jumonji/arid domain-containing protein 0.0282 0.0396 0.0602
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0006 0.0006
Brugia malayi ImpB/MucB/SamB family protein 0.0061 0.0062 0.0062
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0024 0.0006 0.0007
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0274 0.0383 0.0583
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0062 0.0058
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0076 0.0084 0.0939
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.4369 0.6576 1
Leishmania major pteridine reductase 1 0.0024 0.0006 0.0003
Brugia malayi Dopamine receptor protein 1 0.0637 0.0933 0.0933
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Mycobacterium ulcerans short-chain type oxidoreductase 0.0024 0.0006 0.006
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0028 0.0031
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0043 0.0034 0.0052
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0032 0.0017 0.0027
Entamoeba histolytica short chain dehydrogenase family protein 0.0024 0.0006 0.0073
Brugia malayi Cation transporter family protein 0.0043 0.0034 0.0034
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0006 0.006
Leishmania major short chain dehydrogenase, putative 0.0024 0.0006 0.0003
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0012 0.0009
Brugia malayi dehydrogenases, short chain protein 9 0.0024 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0062 0.0063 0.0063
Leishmania major hypothetical protein, conserved 0.0024 0.0006 0.0003
Echinococcus multilocularis lysine specific demethylase 6a 0.0075 0.0083 0.0091
Brugia malayi jmjC domain containing protein 0.0075 0.0083 0.0083
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.0005 0.0007
Trypanosoma brucei glucosidase, putative 0.0076 0.0084 0.008
Echinococcus granulosus tachykinin peptides receptor 99D 0.0274 0.0383 0.0422
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0024 0.0006 0.0073
Echinococcus multilocularis fmrfamide receptor 0.0274 0.0383 0.0422
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0274 0.0383 0.0583
Mycobacterium ulcerans ketoacyl reductase 0.0024 0.0006 0.006
Echinococcus granulosus carbonyl reductase 1 0.0024 0.0006 0.0007
Trypanosoma brucei DNA polymerase eta, putative 0.0061 0.0062 0.0058
Onchocerca volvulus 0.0032 0.0017 0.0024
Plasmodium falciparum transporter, putative 0.0032 0.0017 0.0728
Onchocerca volvulus 0.0186 0.0251 0.038
Trichomonas vaginalis maltase-glucoamylase, putative 0.0076 0.0084 0.0939
Loa Loa (eye worm) hypothetical protein 0.0032 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0005
Echinococcus granulosus g protein coupled receptor 0.0274 0.0383 0.0422
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0112 0.014 0.3211
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0021 0.0001 0.0001
Schistosoma mansoni amine GPCR 0.0274 0.0383 0.0583
Onchocerca volvulus 0.0274 0.0383 0.0581
Brugia malayi Glycosyl hydrolases family 31 protein 0.0076 0.0084 0.0084
Echinococcus multilocularis Polycystic kidney disease protein 0.0124 0.0157 0.0173
Echinococcus multilocularis rhodopsin orphan GPCR 0.0274 0.0383 0.0422
Mycobacterium ulcerans short-chain dehydrogenase 0.0024 0.0006 0.006
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0024 0.0006 0.0006
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0154 0.0203 0.0224
Echinococcus granulosus enteropeptidase 0.0021 0.0001 0.0002
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0186 0.0251 0.0251
Plasmodium vivax multidomain scavenger receptor, putative 0.0124 0.0157 1
Echinococcus granulosus peregrin 0.0034 0.0021 0.0023
Brugia malayi hypothetical protein 0.0024 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Entamoeba histolytica hypothetical protein 0.0024 0.0007 0.0073
Echinococcus multilocularis orexin receptor type 2 0.0274 0.0383 0.0422
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0024 0.0006 0.0007
Plasmodium falciparum M17 leucyl aminopeptidase 0.0112 0.014 0.8825
Leishmania major DNA polymerase kappa, putative 0.0061 0.0062 0.0058
Echinococcus granulosus hypothetical protein 0.0024 0.0006 0.0007
Echinococcus multilocularis cpg binding protein 0.0032 0.0019 0.002
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0274 0.0383 0.0383
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0043 0.0034 0.0034
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.0101 0.0101
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0007 0.0001
Brugia malayi putative neuropeptide receptor NPR1 0.0274 0.0383 0.0383
Loa Loa (eye worm) dehydrogenase 0.0024 0.0006 0.0006
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0061 0.0062 0.0058
Onchocerca volvulus Neuropeptide F receptor homolog 0.0274 0.0383 0.0581
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0072 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0062 0.0058
Schistosoma mansoni neuropeptide F-like receptor 0.0274 0.0383 0.0583
Schistosoma mansoni histamine h1 receptor 0.0274 0.0383 0.0583
Schistosoma mansoni nAChR subunit 0.0043 0.0034 0.0052
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0012 0.0137
Echinococcus multilocularis jumonji domain containing 1A 0.0075 0.0083 0.0091
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0024 0.0006 0.0003
Loa Loa (eye worm) neuropeptide F receptor 0.0274 0.0383 0.0383
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0076 0.0084 0.0939
Echinococcus multilocularis g protein coupled receptor 0.0274 0.0383 0.0422
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0028 0.0242
Schistosoma mansoni phd/f-box containing protein 0.0075 0.0083 0.0126
Echinococcus multilocularis rhodopsin orphan GPCR 0.0274 0.0383 0.0422
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0038 0.2388
Echinococcus multilocularis dro:myosuppressin receptor 0.0274 0.0383 0.0422
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0006 0.0003
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0016 0.0024
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0028 0.0031
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0028 0.1628
Brugia malayi ORL1-like opioid receptor 0.0274 0.0383 0.0383
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0075 0.0083 0.0079
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0032 0.0017 0.0019
Echinococcus granulosus glycine receptor subunit alpha 1 0.0043 0.0034 0.0038
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0028 0.0012 0.0016
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0001 0.0001
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Loa Loa (eye worm) oxidoreductase 0.0024 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0006 0.006
Onchocerca volvulus 0.0043 0.0034 0.005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0274 0.0383 0.0583
Brugia malayi hypothetical protein 0.0274 0.0383 0.0383
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0343 0.0488 0.0537
Schistosoma mansoni hypothetical protein 0.0021 0.0001 0.0002
Schistosoma mansoni jumonji/arid domain-containing protein 0.0282 0.0396 0.0602
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1291 0.1922 0.1922
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0032 0.0017 0.0017
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0274 0.0383 0.0583
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0002 0.0002
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0032 0.0017 0.0019
Brugia malayi Bromodomain containing protein 0.0034 0.0021 0.0021
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0043 0.0034 0.0034
Trichomonas vaginalis DNA polymerase eta, putative 0.0061 0.0062 0.0691
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0066 0.0072
Schistosoma mansoni rab6-interacting 0.0124 0.0157 0.0239
Echinococcus granulosus glycine receptor subunit beta 0.0043 0.0034 0.0038
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0006 0.001
Schistosoma mansoni cpg binding protein 0.0032 0.0019 0.0028
Schistosoma mansoni opsin-like receptor 0.0274 0.0383 0.0583
Brugia malayi neuropeptide F receptor 0.0274 0.0383 0.0383
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0024 0.0006 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0062 0.0058
Onchocerca volvulus 0.0501 0.0727 0.1104
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0274 0.0383 0.0583
Onchocerca volvulus 0.0024 0.0006 0.0008
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0038 0.0428
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0274 0.0383 0.0583
Trypanosoma cruzi short chain dehydrogenase, putative 0.0024 0.0006 0.0003
Schistosoma mansoni adenoreceptor 0.0274 0.0383 0.0583
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0061 0.0062 0.0062
Brugia malayi jmjC domain containing protein 0.0282 0.0396 0.0396
Toxoplasma gondii hypothetical protein 0.0032 0.0017 0.0824
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0274 0.0383 0.0583
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0032 0.0017 0.0027
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0024 0.0006 0.001
Brugia malayi Trypsin family protein 0.0218 0.03 0.03
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0024 0.0006 0.0003
Echinococcus granulosus steroid dehydrogenase 0.0024 0.0006 0.0007
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0032 0.0017 0.0027
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0003 0.0004
Schistosoma mansoni carbonyl reductase 0.0024 0.0006 0.001
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0001 0.0002
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0084 0.0939
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0032 0.0017 0.0019
Loa Loa (eye worm) hypothetical protein 0.0117 0.0147 0.0147
Trypanosoma brucei short-chain dehydrogenase, putative 0.0024 0.0006 0.0003
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0075 0.0083 0.0079
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0006 0.006
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0274 0.0383 0.0583
Leishmania major 3-keto-dihydrosphingosine reductase 0.0024 0.0006 0.0003
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0043 0.0034 0.0038
Leishmania major short chain dehydrogenase/reductase, putative 0.0024 0.0006 0.0003
Echinococcus granulosus retinol dehydrogenase 11 0.0024 0.0006 0.0007
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0186 0.0251 0.0382
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0032 0.0017 0.0019
Echinococcus granulosus dnaJ subfamily B 0.0436 0.0628 0.0692
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0001 0.0002
Schistosoma mansoni inositol monophosphatase 0.0039 0.0028 0.0043
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0028 0.0024
Leishmania major hypothetical protein, conserved 0.0024 0.0006 0.0003
Echinococcus granulosus neuropeptide Y receptor 0.0274 0.0383 0.0422
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0022 0.0003 0.0003
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0043 0.0034 0.0034
Onchocerca volvulus 0.0274 0.0383 0.0581
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0112 0.014 0.0136
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0001 0.0002
Echinococcus multilocularis voltage gated potassium channel 0.0021 0.0001 0.0001
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.0005 0.0005
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0274 0.0383 0.0383
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0024 0.0006 0.0003
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0012 0.0137
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0066 0.0767
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0006 0.0073
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0024 0.0006 0.0073
Echinococcus granulosus neuropeptide receptor A26 0.0274 0.0383 0.0422
Schistosoma mansoni myosin xvIII 0.0274 0.0383 0.0583
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0006 0.001
Onchocerca volvulus 0.0218 0.03 0.0454
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0006 0.0073
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0066 0.0767
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0006 0.001
Echinococcus granulosus glycine receptor subunit beta 0.0043 0.0034 0.0038
Schistosoma mansoni voltage-gated potassium channel 0.0078 0.0087 0.0132
Onchocerca volvulus 0.0274 0.0383 0.0581
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0193 0.0262 0.0288
Mycobacterium ulcerans oxidoreductase 0.0024 0.0006 0.006
Echinococcus granulosus Polycystic kidney disease protein 0.0124 0.0157 0.0173
Brugia malayi Serotonin receptor 0.6548 0.987 0.987
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0043 0.0034 0.0034
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0006 0.0006
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0012 0.0137
Leishmania major hypothetical protein, conserved 0.0024 0.0006 0.0003
Echinococcus granulosus neuropeptide FF receptor 2 0.0274 0.0383 0.0422
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0005
Brugia malayi GnHR receptor homolog 0.0274 0.0383 0.0383
Echinococcus multilocularis carbonyl reductase 1 0.0024 0.0006 0.0007
Echinococcus granulosus hypothetical protein 0.0024 0.0006 0.0007
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0274 0.0383 0.0422
Echinococcus granulosus lysosomal alpha glucosidase 0.0341 0.0485 0.0534
Brugia malayi putative neuropeptide receptor 0.0274 0.0383 0.0383
Brugia malayi Trypsin family protein 0.0021 0.0001 0.0001
Echinococcus granulosus phd:f box containing protein 0.0075 0.0083 0.0091
Onchocerca volvulus 0.0274 0.0383 0.0581
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0043 0.0034 0.0038
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0032 0.0017 0.0027
Echinococcus granulosus nAChR subunit 0.0023 0.0005 0.0005
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0112 0.014 0.0136
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0043 0.0034 0.0034
Schistosoma mansoni opsin-like receptor 0.0274 0.0383 0.0583
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0006 0.001
Leishmania major quinonoid dihydropteridine reductase 0.0024 0.0006 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0062 0.0058
Echinococcus granulosus nAChR subunit 0.0043 0.0034 0.0038
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0032 0.0017 0.0017
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0274 0.0383 0.0422
Loa Loa (eye worm) glutaminase 2 0.0576 0.0841 0.0841
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0024 0.0006 0.0003
Echinococcus granulosus cpg binding protein 0.0032 0.0019 0.002
Echinococcus granulosus neuropeptide receptor 0.0274 0.0383 0.0422
Schistosoma mansoni hypothetical protein 0.0274 0.0383 0.0583
Schistosoma mansoni alpha-glucosidase 0.0293 0.0413 0.0628
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0083 0.0126
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0009 0.0006
Brugia malayi jmjC domain containing protein 0.0075 0.0083 0.0083
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0006 0.006
Loa Loa (eye worm) hypothetical protein 0.0935 0.1383 0.1383
Loa Loa (eye worm) ACC-1 protein 0.0043 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.003 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.0032 0.0017 0.0017
Onchocerca volvulus 0.0274 0.0383 0.0581
Loa Loa (eye worm) hypothetical protein 0.0032 0.0017 0.0017
Schistosoma mansoni glutaminase 0.0576 0.0841 0.1279
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0343 0.0488 0.0537
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0012 0.0137
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0274 0.0383 0.0383
Trichomonas vaginalis sucrase-isomaltase, putative 0.0076 0.0084 0.0939
Trypanosoma cruzi C-8 sterol isomerase, putative 0.6633 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0024 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Echinococcus multilocularis lysine specific demethylase 5A 0.028 0.0393 0.0433
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0076 0.0084 0.5819
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0062 0.0058
Plasmodium falciparum phd finger protein, putative 0.003 0.0016 0.0605
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0028 0.0318
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0006 0.0003
Loa Loa (eye worm) doublecortin family protein 0.0124 0.0157 0.0157
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0024 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Brugia malayi Dehydrogenases, short chain protein 30 0.0024 0.0006 0.0006
Brugia malayi MH2 domain containing protein 0.0127 0.0162 0.0162
Loa Loa (eye worm) serotonin transporter b 0.0186 0.0251 0.0251
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0062 0.0058
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0024 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0274 0.0383 0.0383
Echinococcus multilocularis g-protein coupled receptor 0.0274 0.0383 0.0422
Echinococcus multilocularis neuropeptide s receptor 0.0274 0.0383 0.0422
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0001 0.0001

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 2 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 3.5 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 4.99 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 5.09 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 29 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 65 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 99 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 11.9 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = 2 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 29 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 65 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 99 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.28 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.52769 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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