Detailed information for compound 655944

Basic information

Technical information
  • TDR Targets ID: 655944
  • Name: methyl 2-[(2-chloro-4-nitrobenzoyl)amino]-4,5 ,6,7-tetrahydro-1-benzothiophene-3-carboxylat e
  • MW: 394.829 | Formula: C17H15ClN2O5S
  • H donors: 1 H acceptors: 4 LogP: 4.86 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1c(NC(=O)c2ccc(cc2Cl)[N+](=O)[O-])sc2c1CCCC2
  • InChi: 1S/C17H15ClN2O5S/c1-25-17(22)14-11-4-2-3-5-13(11)26-16(14)19-15(21)10-7-6-9(20(23)24)8-12(10)18/h6-8H,2-5H2,1H3,(H,19,21)
  • InChiKey: ASPLMPZYZVDJNL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • methyl 2-[(2-chloro-4-nitro-benzoyl)amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylate
  • 2-[[(2-chloro-4-nitrophenyl)-oxomethyl]amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylic acid methyl ester
  • 2-[(2-chloro-4-nitro-benzoyl)amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylic acid methyl ester
  • methyl 2-[(2-chloro-4-nitro-phenyl)carbonylamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
  • A2670/0113708
  • ZINC04577023
  • EU-0075066
  • Oprea1_830084

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0008 0.002 0.0017
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0157 0.015
Echinococcus multilocularis vesicular acetylcholine transporter 0.0969 0.9989 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0008 0.0018 0.0033
Plasmodium falciparum LCCL domain-containing protein 0.0013 0.0064 0.0758
Trypanosoma brucei C-14 sterol reductase, putative 0.0023 0.0169 0.0162
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0065 0.0057
Echinococcus multilocularis traf and tnf receptor associated protein 0.0013 0.0065 0.0057
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0065 0.0057
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0063 0.0586 0.7079
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0013 0.0065 0.0364
Leishmania major hypothetical protein, conserved 0.0013 0.0065 0.0057
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0222 0.2231 0.2229
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0086 0.0827 0.2518
Schistosoma mansoni amine GPCR 0.0008 0.002 0.002
Brugia malayi jmjC domain containing protein 0.0021 0.0146 0.0139
Loa Loa (eye worm) hypothetical protein 0.0008 0.0018 0.0016
Schistosoma mansoni bromodomain containing protein 0.0007 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0008 0.0018 0.0016
Brugia malayi CCR4 0.0013 0.0065 0.0057
Schistosoma mansoni lipoxygenase 0.0076 0.0717 0.0717
Trypanosoma cruzi Bromodomain, putative 0.0007 0.0007 0.0005
Brugia malayi putative neuropeptide receptor 0.0008 0.002 0.0012
Onchocerca volvulus 0.0008 0.002 0.0012
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0013 0.0065 0.0062
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.002 0.0012
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0013 0.0065 0.0364
Loa Loa (eye worm) melatonin receptor type 1A 0.0008 0.002 0.0017
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.0157 0.1206
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0008 0.002 0.0012
Leishmania major cytochrome p450-like protein 0.0022 0.0157 0.015
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0041 0.0356 0.4306
Loa Loa (eye worm) hypothetical protein 0.0604 0.6195 0.6194
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0146 0.0143
Echinococcus granulosus lipoxygenase domain containing protein 0.0013 0.0064 0.0057
Trichomonas vaginalis set domain proteins, putative 0.0321 0.3263 1
Brugia malayi Bloom's syndrome protein homolog 0.0013 0.007 0.0063
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0157 0.0155
Leishmania major cytochrome p450-like protein 0.0065 0.0609 0.0602
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0013 0.007 0.0839
Trypanosoma cruzi bromodomain-containing protein 3 0.0007 0.0007 0.0005
Leishmania major hypothetical protein, conserved 0.0171 0.1712 0.1706
Brugia malayi BRM protein 0.0007 0.0007 0.000000000056546
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0022 0.0157 0.1206
Plasmodium vivax bromodomain protein, putative 0.0007 0.0007 0.0089
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.002 0.0012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0178 0.1777 0.5435
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.002 0.002
Onchocerca volvulus 0.0008 0.002 0.0012
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0008 0.002 0.002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0041 0.0361 0.0362
Treponema pallidum fructose-bisphosphate aldolase 0.0178 0.1777 1
Schistosoma mansoni DNA helicase recq1 0.0013 0.007 0.007
Loa Loa (eye worm) CBP-B 0.0007 0.0007 0.0005
Schistosoma mansoni rab6-interacting 0.0013 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Trypanosoma cruzi Bromodomain, putative 0.0007 0.0007 0.0005
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0013 0.0065 0.0781
Loa Loa (eye worm) RecQ helicase 0.0013 0.007 0.0067
Echinococcus multilocularis JmjC domain containing protein 4 0.0021 0.0146 0.0139
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.0157 0.1206
Echinococcus multilocularis fmrfamide receptor 0.0008 0.002 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.002 0.0012
Entamoeba histolytica recQ family helicase, putative 0.0013 0.007 0.0393
Loa Loa (eye worm) bromodomain containing protein 0.0007 0.0007 0.0005
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0008 0.002 0.0012
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0013 0.0065 0.0364
Schistosoma mansoni histamine h1 receptor 0.0008 0.002 0.002
Schistosoma mansoni jumonji/arid domain-containing protein 0.0078 0.0744 0.0744
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0008 0.0001
Echinococcus multilocularis lamin b receptor 0.0023 0.0169 0.0162
Treponema pallidum hypothetical protein 0.0013 0.0065 0.0349
Schistosoma mansoni blooms syndrome DNA helicase 0.0007 0.0003 0.0003
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0008 0.002 0.0012
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0039 0.0333 0.0334
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0013 0.0065 0.0364
Schistosoma mansoni cytochrome P450 0.0022 0.0157 0.0158
Schistosoma mansoni synaptojanin 0.0013 0.0065 0.0065
Brugia malayi Dopamine receptor protein 2 0.0008 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Brugia malayi Cytochrome P450 family protein 0.0043 0.0384 0.0377
Schistosoma mansoni lipoxygenase 0.0053 0.0481 0.0481
Schistosoma mansoni Lamin B receptor (ERG24) 0.0023 0.0169 0.0169
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0008 0.0018 0.0011
Echinococcus granulosus sex peptide receptor 0.0008 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0063 0.0586 0.0579
Echinococcus granulosus phd:f box containing protein 0.0021 0.0146 0.0139
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0171 0.1712 0.1706
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0021 0.0146 0.1765
Leishmania major endonuclease/exonuclease protein-like protein 0.0013 0.0065 0.0057
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0065 0.0062
Giardia lamblia hypothetical protein 0.0013 0.0065 0.0324
Echinococcus granulosus alpha 1A adrenergic receptor 0.0008 0.002 0.0012
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0039 0.0333 0.3496
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0013 0.0065 0.0781
Schistosoma mansoni carbon catabolite repressor protein 0.0013 0.0065 0.0065
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0732 0.0733
Schistosoma mansoni hypothetical protein 0.0007 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0013 0.007 0.0067
Loa Loa (eye worm) CXXC zinc finger family protein 0.0019 0.0127 0.0125
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0013 0.007 0.0063
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0077 0.0732 0.0726
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0008 0.002 0.0012
Echinococcus granulosus 7tm_1 domain containing protein 0.0008 0.002 0.0012
Schistosoma mansoni cpg binding protein 0.002 0.0139 0.0139
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0013 0.0065 0.0364
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0013 0.0065 0.0057
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0086 0.0827 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0013 0.0065 0.0062
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0013 0.007 0.0063
Leishmania major C-8 sterol isomerase-like protein 0.097 1 1
Onchocerca volvulus 0.0008 0.002 0.0012
Echinococcus granulosus orexin receptor type 2 0.0008 0.002 0.0012
Plasmodium falciparum JmjC domain-containing protein, putative 0.0021 0.0146 0.1861
Echinococcus granulosus neutral sphingomyelinase 0.0013 0.0065 0.0057
Schistosoma mansoni phd/f-box containing protein 0.0021 0.0146 0.0146
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0178 0.1777 1
Echinococcus multilocularis RUN 0.0013 0.0064 0.0057
Loa Loa (eye worm) hypothetical protein 0.0496 0.5078 0.5077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0178 0.1777 0.5435
Echinococcus granulosus neuropeptide Y receptor 0.0008 0.002 0.0012
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0008 0.002 0.0012
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.0157 0.1206
Onchocerca volvulus 0.0321 0.3263 0.3262
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0008 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0044 0.0385 0.0382
Echinococcus multilocularis neuropeptides capa receptor 0.0008 0.002 0.0012
Brugia malayi jmjC domain containing protein 0.0078 0.0744 0.0737
Trypanosoma cruzi sterol C-24 reductase, putative 0.0023 0.0169 0.0166
Brugia malayi jmjC domain containing protein 0.0021 0.0146 0.0139
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0013 0.0064 0.0061
Schistosoma mansoni polybromo-1 0.0007 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.054 0.5533 0.5539
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0157 0.015
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0007 0.0007 0.0089
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0008 0.002 0.0012
Trypanosoma cruzi Bromodomain, putative 0.0007 0.0007 0.0005
Schistosoma mansoni growth hormone secretagogue receptor 0.0008 0.002 0.002
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.007 0.0192
Schistosoma mansoni biogenic amine receptor 0.0008 0.002 0.002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0178 0.1777 0.5435
Brugia malayi Dopamine receptor protein 1 0.0008 0.002 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.002 0.002
Onchocerca volvulus 0.0013 0.0065 0.0057
Brugia malayi Tachykinin-like peptides receptor 99D 0.0008 0.002 0.0012
Brugia malayi Dopamine receptor 0.0008 0.002 0.0012
Trypanosoma cruzi sterol C-24 reductase, putative 0.0023 0.0169 0.0166
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0005
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0086 0.0827 1
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.002 0.0017
Echinococcus multilocularis neuropeptide receptor 0.0067 0.0631 0.0625
Onchocerca volvulus 0.0008 0.002 0.0012
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0013 0.0065 0.0176
Schistosoma mansoni neuropeptide F-like receptor 0.0008 0.002 0.002
Echinococcus granulosus histone lysine methyltransferase setb 0.0041 0.0356 0.035
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0063 0.0586 0.6775
Leishmania major cytochrome p450-like protein 0.0022 0.0157 0.015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.002 0.002
Brugia malayi ATPase, AAA family protein 0.0007 0.0007 0.00000034396
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0013 0.0065 0.0065
Brugia malayi hypothetical protein 0.0008 0.002 0.0012
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0008 0.002 0.0012
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0008 0.002 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.002 0.002
Echinococcus granulosus RUN 0.0013 0.0064 0.0057
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.0157 0.1206
Schistosoma mansoni lozenge 0.0076 0.0718 0.0719
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0013 0.0065 0.0176
Trypanosoma cruzi bromodomain factor 2 protein 0.0007 0.0007 0.0005
Brugia malayi ORL1-like opioid receptor 0.0008 0.002 0.0012
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0063 0.0586 0.3268
Echinococcus multilocularis phd:f box containing protein 0.0021 0.0146 0.0139
Echinococcus granulosus G protein coupled receptor 139 0.0008 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Echinococcus granulosus g protein coupled receptor 0.0008 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0008 0.002 0.0012
Plasmodium vivax SET domain containing protein 0.0009 0.0027 0.0326
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.0157 0.1206
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0005
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0008 0.002 0.0012
Echinococcus granulosus 7TM GPCR rhodopsin 0.0008 0.002 0.0012
Brugia malayi hypothetical protein 0.0013 0.0064 0.0057
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0065 0.0057
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0005
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0007 0.0007 0.0007
Schistosoma mansoni amine GPCR 0.0008 0.002 0.002
Brugia malayi larval opioid receptor 0.0008 0.002 0.0012
Schistosoma mansoni biogenic amine (5HT) receptor 0.0008 0.002 0.002
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0021 0.0146 0.0143
Brugia malayi G protein-coupled receptor F59B2.13 0.0008 0.002 0.0012
Echinococcus granulosus histone acetyltransferase KAT2B 0.0285 0.2889 0.2887
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0013 0.0065 0.0062
Schistosoma mansoni opsin-like receptor 0.0008 0.002 0.002
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.002 0.0012
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0008 0.002 0.0012
Echinococcus granulosus jumonji domain containing 1A 0.0021 0.0146 0.0139
Echinococcus granulosus JmjC domain containing protein 4 0.0021 0.0146 0.0139
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0008 0.002 0.002
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0039 0.0333 0.0327
Loa Loa (eye worm) hypothetical protein 0.0013 0.0065 0.0062
Echinococcus multilocularis lipoxygenase domain containing protein 0.0013 0.0064 0.0057
Trichomonas vaginalis ap endonuclease, putative 0.0063 0.0586 0.1776
Schistosoma mansoni neuropeptide F-like receptor 0.0008 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Brugia malayi hypothetical protein 0.0604 0.6195 0.6192
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.0007 0.0007 0.00000034434
Echinococcus granulosus serotonin receptor 0.0008 0.002 0.0012
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0013 0.0065 0.0062
Schistosoma mansoni jumonji/arid domain-containing protein 0.0078 0.0744 0.0744
Loa Loa (eye worm) bromodomain containing protein 0.0007 0.0007 0.0005
Trichomonas vaginalis Phospholipase C precursor, putative 0.0013 0.0065 0.0176
Schistosoma mansoni neuropeptide f receptor 76f 0.0008 0.002 0.002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0178 0.1777 0.5435
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0013 0.0065 0.0781
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Brugia malayi PHD-finger family protein 0.0008 0.0018 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0065 0.0062
Brugia malayi vesicular acetylcholine transporter unc-17 0.0969 0.9989 0.9989
Trypanosoma cruzi Bromodomain, putative 0.0007 0.0007 0.0005
Trypanosoma cruzi cytochrome P450, putative 0.0065 0.0609 0.0607
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.002 0.0017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0178 0.1777 0.5435
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0013 0.007 0.0063
Echinococcus multilocularis synaptojanin 1 0.0013 0.0065 0.0057
Echinococcus multilocularis G protein coupled receptor 139 0.0067 0.0631 0.0625
Schistosoma mansoni amine GPCR 0.0008 0.002 0.002
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0013 0.0065 0.0176
Onchocerca volvulus 0.0008 0.002 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.002 0.002
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0013 0.0065 0.0176
Echinococcus multilocularis geminin 0.054 0.5533 0.5536
Schistosoma mansoni hypothetical protein 0.0008 0.002 0.002
Echinococcus multilocularis orexin receptor type 2 0.0008 0.002 0.0012
Brugia malayi jmjC domain containing protein 0.0021 0.0146 0.0139
Echinococcus granulosus tm gpcr rhodopsin 0.0318 0.3233 0.3232
Onchocerca volvulus 0.0171 0.1712 0.1707
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0013 0.0065 0.0062
Loa Loa (eye worm) hypothetical protein 0.0041 0.0356 0.0354
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0008 0.0018 0.0033
Brugia malayi jmjC domain containing protein 0.0021 0.0146 0.0139
Brugia malayi Serotonin receptor 0.0008 0.002 0.0012
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.002 0.0012
Schistosoma mansoni bromodomain containing protein 0.0008 0.0018 0.0018
Schistosoma mansoni CREB-binding protein 2 0.0007 0.0007 0.0007
Echinococcus granulosus bloom syndrome protein 0.0013 0.007 0.0063
Schistosoma mansoni amine GPCR 0.0008 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0064 0.0061
Toxoplasma gondii hypothetical protein 0.0007 0.0007 0.0089
Echinococcus granulosus g-protein coupled receptor 0.0008 0.002 0.0012
Trypanosoma brucei Emopamil binding protein, putative 0.0171 0.1712 0.1706
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.007 0.0192
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0013 0.0065 0.0062
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.007 0.0063
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0065 0.0062
Echinococcus granulosus biogenic amine 5HT receptor 0.0008 0.002 0.0012
Brugia malayi hypothetical protein 0.0171 0.1703 0.1697
Echinococcus granulosus peptide allatostatin:somatostatin 0.0008 0.002 0.0012
Echinococcus multilocularis cpg binding protein 0.002 0.0139 0.0132
Echinococcus multilocularis neuropeptide receptor A26 0.0008 0.002 0.0012
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0008 0.002 0.0012
Brugia malayi RE15519p 0.0008 0.002 0.0012
Onchocerca volvulus 0.0013 0.0064 0.0057
Onchocerca volvulus Putative neutral sphingomyelinase 0.0013 0.0065 0.0057
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0063 0.0586 0.5
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0013 0.0065 0.0364
Giardia lamblia Transcription regulatory protein SNF2 0.0007 0.0007 0.00000000031931
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0065 0.0609 0.668
Echinococcus multilocularis lysine specific demethylase 5A 0.0077 0.0732 0.0726
Brugia malayi Cytochrome P450 family protein 0.0065 0.0609 0.0602
Schistosoma mansoni hypothetical protein 0.054 0.5533 0.5539
Brugia malayi hypothetical protein 0.0008 0.002 0.0012
Echinococcus granulosus lamin b receptor 0.0023 0.0169 0.0162
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Brugia malayi hypothetical protein 0.0008 0.002 0.0012
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0039 0.0333 0.0326
Schistosoma mansoni adenoreceptor 0.0008 0.002 0.002
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0039 0.0333 0.0327
Trypanosoma brucei cytochrome P450, putative 0.0065 0.0609 0.0602
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0087 0.0834 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.0157 0.1206
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0008 0.002 0.0012
Schistosoma mansoni microtubule-associated protein tau 0.0882 0.9083 0.9093
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0008 0.0018 0.0011
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0021 0.0146 0.0146
Schistosoma mansoni helicase 0.0007 0.0007 0.0007
Echinococcus granulosus neuropeptide s receptor 0.0008 0.002 0.0012
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0013 0.0065 0.0176
Plasmodium vivax bromodomain protein, putative 0.0007 0.0007 0.0089
Loa Loa (eye worm) runx1 0.0076 0.0718 0.0716
Echinococcus multilocularis allatostatin A receptor 0.0008 0.002 0.0012
Trypanosoma cruzi C-8 sterol isomerase, putative 0.097 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.002 0.002
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0021 0.0146 0.0143
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0063 0.0586 0.0579
Brugia malayi hypothetical protein 0.0008 0.002 0.0012
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0008 0.0001
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0008 0.002 0.0012
Schistosoma mansoni hypothetical protein 0.0007 0.0007 0.0007
Schistosoma mansoni opsin-like receptor 0.0008 0.002 0.002
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0065 0.0062
Onchocerca volvulus 0.0008 0.002 0.0012
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0013 0.0065 0.0062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0178 0.1777 0.5435
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Plasmodium falciparum bromodomain protein 1 0.0007 0.0007 0.00000023554
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0008 0.002 0.0012
Leishmania major pantothenate kinase subunit, putative 0.0013 0.0065 0.0057
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0021 0.0146 0.0139
Giardia lamblia Fructose-bisphosphate aldolase 0.0178 0.1777 1
Toxoplasma gondii bromodomain-containing protein 0.0007 0.0007 0.0089
Onchocerca volvulus 0.0008 0.002 0.0012
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0008 0.002 0.0012
Echinococcus granulosus neuropeptide receptor A26 0.0008 0.002 0.0012
Schistosoma mansoni amine GPCR 0.0008 0.002 0.002
Onchocerca volvulus 0.0041 0.0356 0.035
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0008 0.002 0.002
Trypanosoma cruzi C-14 sterol reductase, putative 0.0023 0.0169 0.0166
Echinococcus multilocularis serotonin receptor 0.0008 0.002 0.0012
Brugia malayi CXXC zinc finger family protein 0.0019 0.0127 0.012
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0013 0.0065 0.0057
Brugia malayi Doublecortin family protein 0.0013 0.0064 0.0057
Brugia malayi putative neuropeptide receptor NPR1 0.0008 0.002 0.0012
Schistosoma mansoni ap endonuclease 0.0063 0.0586 0.0586
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0013 0.007 0.0067
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0008 0.002 0.002
Onchocerca volvulus 0.0008 0.002 0.0012
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0065 0.0057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.002 0.0012
Schistosoma mansoni neuropeptide receptor 0.0008 0.002 0.002
Echinococcus multilocularis g protein coupled receptor 0.0008 0.002 0.0012
Schistosoma mansoni jumonji domain containing protein 0.0021 0.0146 0.0146
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.0157 0.1206
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0063 0.0586 0.0579
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0063 0.0586 0.6333
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0013 0.0065 0.0057
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0065 0.0057
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.0157 0.1206
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0013 0.0065 0.0364
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0013 0.007 0.0063
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0013 0.0065 0.0781
Brugia malayi G protein-coupled receptor 0.0008 0.002 0.0012
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0039 0.0333 0.2604
Trypanosoma cruzi Emopamil binding protein, putative 0.0171 0.1712 0.1709
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0005
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0013 0.0065 0.0062
Loa Loa (eye worm) histone methyltransferase 0.0007 0.0008 0.0006
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0013 0.0065 0.0781
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0013 0.0065 0.0057
Entamoeba histolytica recQ family DNA helicase 0.0007 0.0003 0.0015
Brugia malayi sulfakinin receptor protein 0.0008 0.002 0.0012
Schistosoma mansoni hypothetical protein 0.0013 0.0065 0.0065
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0039 0.0337 0.033
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0065 0.0057
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0008 0.002 0.0012
Schistosoma mansoni biogenic amine receptor 0.0008 0.002 0.002
Echinococcus granulosus tachykinin peptides receptor 99D 0.0008 0.002 0.0012
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.007 0.0067
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0008 0.002 0.0012
Onchocerca volvulus 0.0008 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Entamoeba histolytica acetyltransferase, GNAT family 0.0079 0.0753 0.4236
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0013 0.0065 0.0768
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0013 0.0065 0.0057
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0065 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.0157 0.1206
Echinococcus multilocularis neuropeptides capa receptor 0.0008 0.002 0.0012
Echinococcus granulosus zinc finger protein 0.0008 0.0018 0.0011
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.0007 0.0007 0.00000034434
Trichomonas vaginalis lymphoid specific helicase, putative 0.0007 0.0007 0.00000000017354
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0318 0.3233 0.3232
Schistosoma mansoni hypothetical protein 0.0008 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0013 0.0065 0.0057
Echinococcus multilocularis global transcription activator snf2l2 0.0007 0.0007 0.00000000005661
Schistosoma mansoni loxhd1 0.0013 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0013 0.0065 0.0364
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0039 0.0333 0.2604
Loa Loa (eye worm) hypothetical protein 0.0013 0.0065 0.0062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0178 0.1777 0.5435
Toxoplasma gondii histone lysine methyltransferase SET1 0.0044 0.0392 0.4733
Loa Loa (eye worm) acetyltransferase 0.0293 0.2975 0.2973
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.0157 0.1206
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.0157 0.1206
Schistosoma mansoni neutral sphingomyelinase 0.0013 0.0065 0.0065
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0008 0.002 0.002
Echinococcus granulosus lysine specific demethylase 5A 0.0078 0.0744 0.0738
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.002 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.0157 0.1206
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.002 0.0012
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0013 0.0065 0.0781
Leishmania major sterol C-24 reductase, putative 0.0023 0.0169 0.0162
Echinococcus multilocularis zinc finger protein 0.0008 0.0018 0.0011
Treponema pallidum exodeoxyribonuclease (exoA) 0.0063 0.0586 0.3286
Entamoeba histolytica bromodomain-containing protein 0.0007 0.0007 0.0041
Echinococcus granulosus microtubule associated protein 2 0.0882 0.9083 0.9092
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0178 0.1777 1
Brugia malayi neuropeptide F receptor 0.0008 0.002 0.0012
Echinococcus multilocularis bloom syndrome protein 0.0013 0.007 0.0063
Echinococcus multilocularis neuropeptide receptor 0.0008 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Echinococcus granulosus g protein coupled receptor 0.0008 0.002 0.0012
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0076 0.0717 0.0711
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0013 0.0065 0.0781
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0157 0.015
Schistosoma mansoni synaptojanin 0.0013 0.0065 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0041 0.0356 0.0357
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.002 0.0012
Echinococcus multilocularis neuropeptide Y receptor 0.0008 0.002 0.0012
Echinococcus multilocularis deoxyribonuclease 1 2 0.0013 0.0065 0.0057
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.002 0.0012
Schistosoma mansoni hypothetical protein 0.0022 0.0157 0.0158
Giardia lamblia Inositol 5-phosphatase 4 0.0013 0.0065 0.0324
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0171 0.1712 0.1709
Schistosoma mansoni bromodomain containing 0.0007 0.0007 0.0007
Trypanosoma cruzi Bromodomain factor 1 0.0007 0.0007 0.0005
Brugia malayi neuropeptide F receptor 0.0008 0.002 0.0012
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0013 0.007 0.0844
Brugia malayi hypothetical protein 0.0013 0.0064 0.0057
Brugia malayi Pre-SET motif family protein 0.0041 0.0356 0.0349
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Onchocerca volvulus 0.0604 0.6195 0.6199
Loa Loa (eye worm) hypothetical protein 0.0604 0.6195 0.6194
Schistosoma mansoni transcription initiation factor tfiid 0.0007 0.0007 0.0007
Loa Loa (eye worm) cytochrome P450 0.0022 0.0157 0.0155
Loa Loa (eye worm) transcription factor SMAD2 0.0076 0.0726 0.0724
Brugia malayi Cytochrome P450 family protein 0.0065 0.0609 0.0602
Echinococcus granulosus Polycystic kidney disease protein 0.0013 0.0064 0.0057
Trypanosoma cruzi Emopamil binding protein, putative 0.0171 0.1712 0.1709
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0013 0.0065 0.0364
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0013 0.0065 0.0364
Giardia lamblia Sgs1 DNA helicase, putative 0.0013 0.007 0.0353
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0008 0.002 0.0012
Trypanosoma brucei RNA editing exonuclease 2 0.0013 0.0065 0.0057
Loa Loa (eye worm) hypothetical protein 0.0013 0.0065 0.0062
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Echinococcus multilocularis 0.0022 0.0157 0.015
Onchocerca volvulus Huntingtin homolog 0.0171 0.1703 0.1699
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0007 0.0007 0.0089
Schistosoma mansoni hypothetical protein 0.0008 0.002 0.002
Loa Loa (eye worm) MH2 domain-containing protein 0.0076 0.0726 0.0724
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Echinococcus multilocularis Protein lozenge 0.0076 0.0718 0.0712
Leishmania major hypothetical protein, conserved 0.0013 0.0065 0.0057
Brugia malayi hypothetical protein 0.0008 0.002 0.0012
Loa Loa (eye worm) doublecortin family protein 0.0013 0.0064 0.0061
Plasmodium falciparum histone acetyltransferase GCN5 0.0079 0.0753 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0008 0.002 0.0012
Onchocerca volvulus 0.0008 0.002 0.0012
Onchocerca volvulus 0.0008 0.002 0.0012
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.002 0.0012
Onchocerca volvulus 0.0019 0.0127 0.012
Echinococcus granulosus dro:myosuppressin receptor 0.0008 0.002 0.0012
Echinococcus granulosus synaptojanin 1 0.0013 0.0065 0.0057
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0013 0.007 0.0063
Echinococcus multilocularis g protein coupled receptor 0.0008 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.097 1 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.0157 0.1206
Echinococcus multilocularis g-protein coupled receptor 0.0008 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Brugia malayi G-protein coupled receptor 0.0008 0.002 0.0012
Onchocerca volvulus 0.0013 0.0064 0.0057
Schistosoma mansoni rab6-interacting 0.0013 0.0064 0.0064
Entamoeba histolytica bromodomain-containing protein 0.0007 0.0007 0.0041
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0065 0.0781
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0146 0.0143
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0063 0.0586 0.0583
Loa Loa (eye worm) cytochrome P450 family protein 0.0043 0.0384 0.0381
Schistosoma mansoni cript-related 0.0013 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Toxoplasma gondii histone acetyltransferase TAF1/250 0.0007 0.0007 0.0089
Echinococcus granulosus allatostatin A receptor 0.0008 0.002 0.0012
Loa Loa (eye worm) TYRA-2 protein 0.0008 0.002 0.0017
Schistosoma mansoni opsin-like receptor 0.0008 0.002 0.002
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0157 0.1902
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0021 0.0146 0.1765
Echinococcus granulosus fmrfamide receptor 0.0008 0.002 0.0012
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0157 0.015
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0013 0.0065 0.0364
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0157 0.0155
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.002 0.0012
Echinococcus multilocularis neutral sphingomyelinase 0.0013 0.0065 0.0057
Echinococcus multilocularis fmrfamide receptor 0.0008 0.002 0.0012
Schistosoma mansoni biogenic amine (5HT) receptor 0.0008 0.002 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.002 0.0012
Trypanosoma cruzi cytochrome P450, putative 0.0065 0.0609 0.0607
Leishmania major hypothetical protein, conserved 0.0013 0.0065 0.0057
Brugia malayi Serotonin receptor 0.0008 0.002 0.0012
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0086 0.0827 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.002 0.002
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.0007 0.0007 0.0007
Echinococcus granulosus neuropeptides capa receptor 0.0008 0.002 0.0012
Echinococcus multilocularis serotonin receptor 0.0008 0.002 0.0012
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0008 0.002 0.002
Schistosoma mansoni protein phosphatase 2C 0.0021 0.0146 0.0146
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0013 0.0065 0.0768
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0065 0.0057
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0041 0.0356 0.035
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.0157 0.1206
Toxoplasma gondii exonuclease III APE 0.0063 0.0586 0.7079
Brugia malayi Bromodomain containing protein 0.0008 0.0018 0.0011
Trichomonas vaginalis bromodomain-containing protein, putative 0.0086 0.0827 0.2518
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.002 0.002
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.0157 0.1206
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0063 0.0586 0.0583
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0076 0.0717 0.0711
Brugia malayi exodeoxyribonuclease III family protein 0.0063 0.0586 0.0579
Onchocerca volvulus 0.0008 0.002 0.0012
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0013 0.0065 0.0057
Schistosoma mansoni cpg binding protein 0.0019 0.0127 0.0128
Echinococcus multilocularis lipoxygenase domain containing protein 0.0013 0.0064 0.0057
Loa Loa (eye worm) hypothetical protein 0.0171 0.1703 0.1701
Brugia malayi AKH receptor 0.0008 0.002 0.0012
Plasmodium vivax hypothetical protein, conserved 0.0007 0.0007 0.0089
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0063 0.0586 0.0579
Echinococcus granulosus hypothetical protein 0.0008 0.002 0.0012
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0013 0.0065 0.0176
Schistosoma mansoni neuropeptide receptor 0.0067 0.0631 0.0632
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0293 0.2975 0.2978
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0039 0.0333 0.0326
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0065 0.0057
Onchocerca volvulus 0.0008 0.002 0.0012
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0087 0.0834 1
Echinococcus granulosus global transcription activator snf2l2 0.0007 0.0007 0.00000000005661
Trypanosoma cruzi mitochondrial protein 99, putative 0.0013 0.0065 0.0062
Loa Loa (eye worm) CYP4Cod1 0.0065 0.0609 0.0607
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0178 0.1777 0.5435
Leishmania major RNA-editing complex protein MP100, putative 0.0013 0.0065 0.0057
Brugia malayi GnHR receptor homolog 0.0008 0.002 0.0012
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0008 0.002 0.0017
Trichomonas vaginalis ap endonuclease, putative 0.0063 0.0586 0.1776
Schistosoma mansoni myosin xvIII 0.0008 0.002 0.002
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0013 0.0065 0.0781
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0008 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Entamoeba histolytica bromodomain-containing protein 0.0007 0.0007 0.0041
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0077 0.0732 0.0726
Entamoeba histolytica bromodomain-containing protein 0.0007 0.0007 0.0041
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.002 0.002
Schistosoma mansoni polycystin 1-related 0.0013 0.0064 0.0064
Plasmodium vivax bromodomain protein, putative 0.0007 0.0007 0.0089
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0065 0.0062
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0013 0.0065 0.0057
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Schistosoma mansoni hypothetical protein 0.0008 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.002 0.0012
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.007 0.0063
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Schistosoma mansoni cpg binding protein 0.002 0.0139 0.0139
Echinococcus granulosus neuropeptide Y receptor 0.0008 0.002 0.0012
Schistosoma mansoni bromodomain containing protein 0.0008 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0005
Loa Loa (eye worm) jmjC domain-containing protein 0.0078 0.0744 0.0741
Trypanosoma brucei C-8 sterol isomerase, putative 0.097 1 1
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0013 0.0065 0.0062
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0013 0.0065 0.0781
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0065 0.0062
Schistosoma mansoni neuropeptide receptor 0.0008 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Echinococcus multilocularis lysine specific demethylase 6a 0.0021 0.0146 0.0139
Trypanosoma cruzi Bromodomain, putative 0.0007 0.0007 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.0157 0.1206
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0063 0.0586 0.7758
Loa Loa (eye worm) hypothetical protein 0.0021 0.0146 0.0143
Schistosoma mansoni nocturnin 0.0013 0.0065 0.0065
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0065 0.0057
Plasmodium falciparum DNase I-like protein, putative 0.0013 0.0065 0.0768
Brugia malayi hypothetical protein 0.0008 0.002 0.0012
Echinococcus granulosus neuropeptide FF receptor 2 0.0008 0.002 0.0012
Brugia malayi Melatonin receptor type 1A 0.0008 0.002 0.0012
Entamoeba histolytica bromodomain-containing protein 0.0007 0.0007 0.0041
Schistosoma mansoni DNA helicase recq5 0.0013 0.007 0.007
Echinococcus multilocularis jumonji domain containing 1A 0.0021 0.0146 0.0139
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.002 0.0012
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0013 0.0065 0.0176
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0157 0.015
Plasmodium vivax SET domain protein, putative 0.0041 0.0356 0.4306
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.0157 0.1206
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0065 0.0057
Echinococcus granulosus lysine specific demethylase 6a 0.0021 0.0146 0.0139
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0008 0.002 0.002
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.0157 0.1206
Echinococcus granulosus g protein coupled receptor 0.0008 0.002 0.0012
Giardia lamblia Histone acetyltransferase GCN5 0.0079 0.0753 0.4213
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0007 0.0003 0.0032
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0008 0.002 0.002
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0008 0.002 0.0012
Loa Loa (eye worm) cytochrome P450 family protein 0.0065 0.0609 0.0607
Echinococcus granulosus cpg binding protein 0.002 0.0139 0.0132
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0013 0.007 0.0839
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Echinococcus granulosus geminin 0.054 0.5533 0.5536
Echinococcus multilocularis G-protein coupled receptor, putative 0.0008 0.002 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0007 0.0005
Echinococcus granulosus vesicular acetylcholine transporter 0.0969 0.9989 1
Schistosoma mansoni biogenic amine receptor 0.0008 0.002 0.002
Plasmodium vivax exodeoxyribonuclease III, putative 0.0013 0.0065 0.0781
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.0157 0.1206
Trypanosoma cruzi mitochondrial protein 99, putative 0.0013 0.0065 0.0062
Schistosoma mansoni neuropeptide receptor 0.0008 0.002 0.002
Onchocerca volvulus 0.0008 0.002 0.0012
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0013 0.0065 0.0768
Brugia malayi acetyltransferase, GNAT family protein 0.0293 0.2975 0.2969
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0013 0.0065 0.0057
Echinococcus granulosus lipoxygenase domain containing protein 0.0013 0.0064 0.0057
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0065 0.0057
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Schistosoma mansoni vesicular acetylcholine transporter 0.0969 0.9989 1
Schistosoma mansoni phosphatidylserine receptor 0.0021 0.0146 0.0146
Trypanosoma cruzi C-14 sterol reductase, putative 0.0023 0.0169 0.0166
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0013 0.0065 0.0176
Echinococcus multilocularis neuropeptide FF receptor 2 0.0008 0.002 0.0012
Schistosoma mansoni hypothetical protein 0.0007 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0013 0.0064 0.0064
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0013 0.007 0.0063
Plasmodium vivax multidomain scavenger receptor, putative 0.0013 0.0064 0.0772
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0272 0.2752 0.2751
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.002 0.002
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0171 0.1712 0.1709
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0966 0.9958 0.997
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0013 0.0065 0.0057
Echinococcus multilocularis g protein coupled receptor 0.0008 0.002 0.0012
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0013 0.0065 0.0062
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0013 0.0065 0.0057
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.000000000056519
Echinococcus multilocularis neuropeptide Y receptor 0.0008 0.002 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0041 0.0356 0.0357
Echinococcus granulosus biogenic amine 5HT receptor 0.0008 0.002 0.0012
Plasmodium vivax JmjC domain containing protein 0.0021 0.0146 0.1765
Schistosoma mansoni hypothetical protein 0.0007 0.0007 0.0007
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0282 0.286 0.2858
Toxoplasma gondii bromodomain-containing protein 0.0007 0.0007 0.0089
Brugia malayi hypothetical protein 0.0008 0.002 0.0012
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0008 0.002 0.0012
Echinococcus granulosus traf and tnf receptor associated protein 0.0013 0.0065 0.0057
Echinococcus granulosus histone acetyltransferase KAT2B 0.0086 0.0827 0.0821
Loa Loa (eye worm) hypothetical protein 0.0021 0.0146 0.0143
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0157 0.0155
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0969 0.9989 0.9989
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0356 0.0357
Echinococcus granulosus neuropeptide receptor 0.0008 0.002 0.0012
Toxoplasma gondii bromodomain-containing protein 0.0007 0.0007 0.0089
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0008 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Schistosoma mansoni phd finger protein 0.0007 0.0007 0.0007
Brugia malayi hypothetical protein 0.0008 0.002 0.0012
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0008 0.002 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.002 0.0012
Brugia malayi G-protein coupled receptor 0.0008 0.002 0.0012
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0008 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0146 0.0143
Echinococcus multilocularis microtubule associated protein 2 0.0882 0.9083 0.9092
Echinococcus multilocularis dro:myosuppressin receptor 0.0008 0.002 0.0012
Loa Loa (eye worm) cytochrome P450 family protein 0.0065 0.0609 0.0607
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0041 0.0356 0.035
Schistosoma mansoni alpha-1 adrenergic receptor 0.0008 0.002 0.002
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0013 0.0065 0.0057
Brugia malayi Pre-SET motif family protein 0.0282 0.286 0.2854
Loa Loa (eye worm) hypothetical protein 0.0171 0.1703 0.1701
Leishmania major C-14 sterol reductase, putative 0.0023 0.0169 0.0162
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.002 0.0012
Toxoplasma gondii bromodomain-containing protein 0.0007 0.0007 0.0089
Brugia malayi cytochrome P450 0.0022 0.0157 0.015
Brugia malayi hypothetical protein 0.0008 0.002 0.0012
Onchocerca volvulus 0.0008 0.002 0.0012
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0087 0.0834 1
Echinococcus granulosus somatostatin receptor 0.0008 0.002 0.0012
Echinococcus granulosus neuropeptides capa receptor 0.0008 0.002 0.0012
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0013 0.0065 0.0062
Entamoeba histolytica hypothetical protein 0.0007 0.0007 0.0041
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0063 0.0586 0.0583
Trypanosoma brucei AAA ATPase, putative 0.0007 0.0007 0.00000034396
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.002 0.002
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0013 0.0065 0.0062
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0007 0.0003 0.0032
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Echinococcus multilocularis Polycystic kidney disease protein 0.0013 0.0064 0.0057
Loa Loa (eye worm) BRM protein 0.0007 0.0007 0.0005
Trichomonas vaginalis DNA helicase recq1, putative 0.0013 0.007 0.0192
Schistosoma mansoni ap endonuclease 0.0063 0.0586 0.0586
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0013 0.0065 0.0062
Echinococcus multilocularis neuropeptide s receptor 0.0008 0.002 0.0012
Brugia malayi MH2 domain containing protein 0.0076 0.0726 0.0719
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0041 0.0356 0.0357
Brugia malayi Cytochrome P450 family protein 0.0022 0.0157 0.015
Onchocerca volvulus 0.0008 0.002 0.0012
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0013 0.007 0.0844
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Entamoeba histolytica ankyrin repeat protein, putative 0.0007 0.0007 0.0041
Echinococcus granulosus neuropeptide receptor 0.0067 0.0631 0.0625
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0293 0.2975 0.2973
Schistosoma mansoni zinc finger protein 0.0008 0.0018 0.0018
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0008 0.002 0.0012
Echinococcus multilocularis sex peptide receptor 0.0008 0.002 0.0012
Onchocerca volvulus Huntingtin homolog 0.0171 0.1703 0.1699
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0146 0.0143
Onchocerca volvulus 0.0013 0.0065 0.0057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.002 0.002
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0969 0.9989 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.002 0.0012
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0063 0.0586 0.3296
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0036 0.0306 0.0304
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.002 0.0012
Toxoplasma gondii bromodomain-containing protein 0.0007 0.0007 0.0089
Leishmania major hypothetical protein, conserved 0.0021 0.0146 0.0139
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0017
Onchocerca volvulus 0.0008 0.002 0.0012
Entamoeba histolytica bromodomain-containing protein 0.0007 0.0007 0.0041
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0013 0.0065 0.0768
Brugia malayi follicle stimulating hormone receptor 0.0272 0.2752 0.2747
Echinococcus multilocularis somatostatin receptor 0.0008 0.002 0.0012
Brugia malayi hypothetical protein 0.0008 0.002 0.0012
Brugia malayi jmjC domain containing protein 0.0077 0.0732 0.0726

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.