Detailed information for compound 76253

Basic information

Technical information
  • TDR Targets ID: 76253
  • Name: 3-(2,5-dimethylphenyl)-4-(1-methylindol-3-yl) pyrrole-2,5-dione
  • MW: 330.38 | Formula: C21H18N2O2
  • H donors: 1 H acceptors: 2 LogP: 3.38 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)C1=C(C(=O)NC1=O)c1cn(c2c1cccc2)C)C
  • InChi: 1S/C21H18N2O2/c1-12-8-9-13(2)15(10-12)18-19(21(25)22-20(18)24)16-11-23(3)17-7-5-4-6-14(16)17/h4-11H,1-3H3,(H,22,24,25)
  • InChiKey: AJAGWKXGNBDGDQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(2,5-dimethylphenyl)-4-(1-methyl-3-indolyl)pyrrole-2,5-dione
  • 3-(2,5-dimethylphenyl)-4-(1-methylindol-3-yl)-3-pyrroline-2,5-quinone
  • (Phenylindolyl)maleimide deriv. 77

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Protein kinase C gamma Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C gamma type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Brugia malayi Protein kinase c protein 2 Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis serine threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus Protein kinase C brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Calcium-dependent protein kinase C, putative Get druggable targets OG5_129482 All targets in OG5_129482
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis Protein kinase C, brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus protein kinase C gamma type Get druggable targets OG5_129482 All targets in OG5_129482
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis telomerase reverse transcriptase subunit Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Protein kinase C gamma   697 aa 665 aa 60.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0139 0.1356 0.1928
Toxoplasma gondii hypothetical protein 0.0056 0.0457 0.3308
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0304 0.3154 0.3493
Brugia malayi Pre-SET motif family protein 0.0201 0.2037 0.2897
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0091 0.0835 0.1187
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0218 0.031
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0015 0.0008 0.0019
Brugia malayi Cathepsin L-like precursor 0.0019 0.005 0.0072
Echinococcus multilocularis survival motor neuron protein 1 0.0499 0.5281 0.5849
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0056 0.0457 0.065
Plasmodium falciparum amino acid transporter, putative 0.0056 0.0457 0.3067
Trypanosoma brucei carbonic anhydrase-like protein 0.024 0.2458 0.7797
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0056 0.0457 0.065
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0075 0.066 0.0939
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0015 0.0008 0.0011
Echinococcus multilocularis RUN 0.014 0.1377 0.1524
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0304 0.3154 0.4485
Loa Loa (eye worm) hypothetical protein 0.0056 0.0457 0.065
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0051 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0619 0.1839
Echinococcus multilocularis sodium and chloride dependent glycine 0.0056 0.0457 0.0505
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0143 0.1408 0.3733
Schistosoma mansoni nuclear hormone receptor 0.0143 0.1408 0.1832
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0304 0.3154 0.4485
Loa Loa (eye worm) steroid hormone receptor 0.0304 0.3154 0.4485
Loa Loa (eye worm) hypothetical protein 0.0139 0.1356 0.1928
Echinococcus multilocularis neuropeptide receptor 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.033 0.3436 0.4886
Loa Loa (eye worm) cytochrome P450 0.0029 0.0164 0.0234
Loa Loa (eye worm) hypothetical protein 0.0304 0.3154 0.4485
Echinococcus multilocularis jun protein 0.0459 0.4842 0.5362
Brugia malayi nuclear hormone receptor 0.0143 0.1408 0.2002
Brugia malayi Uncoordinated protein 44 0.0064 0.0541 0.0769
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0064 0.0541 0.0598
Echinococcus granulosus alpha 1A adrenergic receptor 0.0015 0.0008 0.0008
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0568 0.0629
Echinococcus granulosus 7tm_1 domain containing protein 0.0015 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0126 0.1219 0.1586
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.051 0.0461
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0029 0.0164 0.0114
Brugia malayi hypothetical protein 0.0015 0.0008 0.0011
Echinococcus multilocularis musashi 0.0026 0.0132 0.0145
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0304 0.3154 0.4118
Schistosoma mansoni intermediate filament proteins 0.0026 0.0132 0.0162
Onchocerca volvulus 0.0102 0.0956 0.2535
Onchocerca volvulus Putative nachr subunit 0.0139 0.1356 0.3596
Brugia malayi TAR-binding protein 0.0066 0.0568 0.0808
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0143 0.1408 0.1558
Brugia malayi nuclear hormone receptor 0.0304 0.3154 0.4485
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.033 0.3436 0.4487
Echinococcus multilocularis lamin 0.0026 0.0132 0.0145
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.0001 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0619 0.1839
Loa Loa (eye worm) hypothetical protein 0.0064 0.0544 0.0773
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0139 0.1356 0.1928
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0139 0.1356 0.1928
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.005 0.0212
Echinococcus granulosus RNA directed DNA polymerase 0.0048 0.0366 0.0405
Onchocerca volvulus 0.0143 0.1408 0.3733
Echinococcus granulosus GPCR family 2 0.0034 0.0218 0.0241
Schistosoma mansoni hypothetical protein 0.0073 0.0647 0.0837
Schistosoma mansoni zinc finger protein 0.0143 0.1408 0.1832
Schistosoma mansoni carbonic anhydrase 0.0055 0.0443 0.0569
Onchocerca volvulus 0.0091 0.0835 0.2213
Brugia malayi hypothetical protein 0.0056 0.0457 0.065
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Brugia malayi G-protein coupled receptor 0.0015 0.0008 0.0011
Brugia malayi hypothetical protein 0.0015 0.0008 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0304 0.3154 0.4485
Schistosoma mansoni acetylcholine receptor-related 0.0064 0.0544 0.0701
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.024 0.2458 0.3496
Echinococcus granulosus survival motor neuron protein 1 0.0499 0.5281 0.5849
Echinococcus granulosus glycine receptor subunit alpha 1 0.0139 0.1356 0.1501
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0056 0.0457 0.0588
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0064 0.0544 0.0773
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0029 0.0164 0.0114
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.051 0.0563
Loa Loa (eye worm) cysteine protease 0.0019 0.005 0.0072
Echinococcus multilocularis g protein coupled receptor 0.0015 0.0008 0.0008
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0029 0.0164 0.0114
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0029 0.0164 0.0114
Loa Loa (eye worm) hypothetical protein 0.0064 0.0544 0.0773
Onchocerca volvulus 0.0229 0.2345 0.6222
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0304 0.3154 0.8367
Echinococcus granulosus orexin receptor type 2 0.0015 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0304 0.3154 0.4485
Echinococcus multilocularis serotonin transporter 0.033 0.3436 0.3805
Echinococcus granulosus cathepsin l1 0.0019 0.005 0.0055
Brugia malayi hypothetical protein 0.0064 0.0544 0.0773
Mycobacterium ulcerans putative regulatory protein 0.004 0.0283 0.0233
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0029 0.0164 0.0114
Loa Loa (eye worm) hypothetical protein 0.0064 0.0541 0.0769
Onchocerca volvulus 0.0015 0.0008 0.0019
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.051 0.0461
Loa Loa (eye worm) hypothetical protein 0.0102 0.096 0.1365
Schistosoma mansoni hypothetical protein 0.0034 0.0218 0.0275
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0619 0.197
Onchocerca volvulus 0.0056 0.0457 0.1211
Loa Loa (eye worm) nuclear hormone receptor 0.0143 0.1408 0.2002
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0015 0.0008 0.0008
Brugia malayi Serotonin receptor 0.0459 0.4847 0.6893
Schistosoma mansoni hypothetical protein 0.014 0.1377 0.1791
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0008 0.0008
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0139 0.1356 0.1501
Loa Loa (eye worm) hypothetical protein 0.033 0.3436 0.4886
Brugia malayi hypothetical protein 0.0064 0.0544 0.0773
Schistosoma mansoni fatty-acid amide hydrolase 0.0098 0.092 0.1194
Echinococcus multilocularis fmrfamide receptor 0.0015 0.0008 0.0008
Leishmania major protein kinase, putative 0.0019 0.0056 0.0177
Loa Loa (eye worm) hypothetical protein 0.0064 0.0544 0.0773
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0056 0.0457 0.065
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0132 0.128 0.3981
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0029 0.0164 0.0114
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0056 0.0457 0.0505
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0015 0.0008 0.0008
Echinococcus granulosus glycine receptor subunit beta 0.0139 0.1356 0.1501
Schistosoma mansoni sodium-dependent amino acid transporter 0.0056 0.0457 0.0588
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0162 0.0202
Loa Loa (eye worm) ACC-1 protein 0.0139 0.1356 0.1928
Loa Loa (eye worm) hypothetical protein 0.014 0.1377 0.1958
Onchocerca volvulus Peroxidase homolog 0.0102 0.096 0.2545
Loa Loa (eye worm) ACC-1 protein 0.0139 0.1356 0.1928
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0051 0.0215
Brugia malayi Death domain containing protein 0.0064 0.0541 0.0769
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0344 0.3593 0.3593
Onchocerca volvulus 0.033 0.3436 0.9115
Brugia malayi hypothetical protein 0.014 0.1377 0.1958
Loa Loa (eye worm) hypothetical protein 0.016 0.1595 0.2268
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.005 0.0212
Onchocerca volvulus 0.0015 0.0008 0.0019
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0162 0.0179
Brugia malayi protein kinase C II. 0.0019 0.0056 0.008
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0029 0.0164 0.0114
Loa Loa (eye worm) hypothetical protein 0.0102 0.096 0.1365
Echinococcus multilocularis Ankyrin 0.0064 0.0547 0.0605
Leishmania major cytochrome p450-like protein 0.0047 0.0356 0.1132
Loa Loa (eye worm) hypothetical protein 0.0073 0.0647 0.092
Onchocerca volvulus Neuropeptide F receptor homolog 0.0015 0.0008 0.0019
Loa Loa (eye worm) hypothetical protein 0.0304 0.3154 0.4485
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0223 0.0952
Onchocerca volvulus 0.0015 0.0008 0.0019
Loa Loa (eye worm) hypothetical protein 0.0143 0.1408 0.2002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0218 0.0241
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0139 0.1356 0.1764
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Brugia malayi hypothetical protein 0.0015 0.0008 0.0011
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0356 0.0506
Brugia malayi hypothetical protein 0.0102 0.096 0.1365
Brugia malayi Cathepsin L-like precursor 0.0019 0.005 0.0072
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.051 0.1622
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.025 0.0355
Onchocerca volvulus 0.0102 0.096 0.2545
Onchocerca volvulus 0.0015 0.0008 0.0019
Echinococcus multilocularis g protein coupled receptor 0.0015 0.0008 0.0008
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.1405 0.4386
Schistosoma mansoni nuclear hormone receptor 0.0143 0.1408 0.1832
Toxoplasma gondii hypothetical protein 0.0056 0.0457 0.3308
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Loa Loa (eye worm) hypoxia-induced factor 1 0.0167 0.1667 0.2371
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0162 0.0202
Echinococcus multilocularis cysteine protease 0.0019 0.005 0.0055
Brugia malayi neuropeptide F receptor 0.0015 0.0008 0.0011
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0614 0.653 0.7232
Brugia malayi hypothetical protein 0.0064 0.0544 0.0773
Schistosoma mansoni retinoid-x-receptor (RXR) 0.016 0.1595 0.2077
Schistosoma mansoni peroxidasin 0.0102 0.096 0.1246
Brugia malayi hypothetical protein 0.0499 0.5281 0.751
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0029 0.0164 0.0114
Schistosoma mansoni retinoic acid receptor RXR 0.0614 0.653 0.8537
Brugia malayi bZIP transcription factor family protein 0.0459 0.4842 0.6885
Onchocerca volvulus 0.0015 0.0008 0.0019
Loa Loa (eye worm) fibroinase 0.0019 0.005 0.0072
Brugia malayi Animal haem peroxidase family protein 0.0102 0.096 0.1365
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0056 0.0457 0.0588
Echinococcus granulosus geminin 0.0347 0.3621 0.401
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0619 0.1839
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0015 0.0008 0.0011
Onchocerca volvulus Protein ultraspiracle homolog 0.0304 0.3154 0.8367
Echinococcus granulosus lipoxygenase domain containing protein 0.014 0.1377 0.1524
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.1219 0.135
Echinococcus multilocularis serotonin receptor 0.0015 0.0008 0.0008
Echinococcus multilocularis carbonic anhydrase II 0.024 0.2458 0.2722
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0311 0.0988
Loa Loa (eye worm) carbonic anhydrase 3 0.024 0.2458 0.3496
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0008 0.0008
Echinococcus multilocularis G-protein coupled receptor, putative 0.0015 0.0008 0.0008
Echinococcus multilocularis g-protein coupled receptor 0.0015 0.0008 0.0008
Onchocerca volvulus 0.0139 0.1356 0.3596
Loa Loa (eye worm) hypothetical protein 0.0064 0.0544 0.0773
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0139 0.1356 0.1501
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.0356 0.1132
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0008 0.0008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0304 0.3154 0.3493
Mycobacterium ulcerans proteasome PrcA 0.0932 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0051 0.016
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.0835 0.1187
Loa Loa (eye worm) hypothetical protein 0.0304 0.3154 0.4485
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0304 0.3154 0.4485
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0008 0.0008
Schistosoma mansoni nAChR subunit 0.0139 0.1356 0.1764
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0056 0.0457 0.0505
Brugia malayi nuclear hormone receptor family member odr-7 0.0143 0.1408 0.2002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0544 0.0773
Onchocerca volvulus 0.0015 0.0008 0.0019
Echinococcus granulosus neuropeptide receptor 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0064 0.0547 0.0778
Brugia malayi Animal haem peroxidase family protein 0.0102 0.096 0.1365
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0064 0.0544 0.0773
Loa Loa (eye worm) hypothetical protein 0.0034 0.0218 0.031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0304 0.3154 0.4485
Schistosoma mansoni neurotransmitter gated ion channel 0.0064 0.0544 0.0701
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.005 0.0212
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.051 0.0656
Echinococcus multilocularis geminin 0.0347 0.3621 0.401
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0619 0.1839
Brugia malayi Serotonin receptor 0.0015 0.0008 0.0011
Schistosoma mansoni neurotransmitter gated ion channel 0.0075 0.066 0.0854
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.005 0.0072
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0132 0.128 0.9272
Loa Loa (eye worm) hypothetical protein 0.0032 0.0197 0.028
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.0356 0.1132
Echinococcus granulosus lamin 0.0026 0.0132 0.0145
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0544 0.0773
Schistosoma mansoni hypothetical protein 0.015 0.1483 0.1931
Loa Loa (eye worm) hypothetical protein 0.066 0.7032 1
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0064 0.0544 0.0601
Brugia malayi Cathepsin L-like precursor 0.0019 0.005 0.0072
Loa Loa (eye worm) acetylcholine receptor protein 0.0064 0.0544 0.0773
Loa Loa (eye worm) hypothetical protein 0.0143 0.1408 0.2002
Brugia malayi putative neuropeptide receptor 0.0015 0.0008 0.0011
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0311 0.0988
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0064 0.0544 0.0773
Schistosoma mansoni hypothetical protein 0.0034 0.0218 0.0275
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0075 0.066 0.0939
Loa Loa (eye worm) hypothetical protein 0.0075 0.066 0.0939
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.025 0.0276
Echinococcus granulosus lamin dm0 0.0026 0.0132 0.0145
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0139 0.1356 0.1764
Leishmania major protein kinase, putative 0.0014 0.0003 0.0008
Echinococcus granulosus biogenic amine 5HT receptor 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0139 0.1356 0.1928
Brugia malayi Peroxidasin 0.0102 0.096 0.1365
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0064 0.0544 0.0773
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0619 0.1839
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0304 0.3154 0.4485
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0356 0.0506
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0139 0.1356 0.1928
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0051 0.0056
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0164 0.0522
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0055 0.0443 0.063
Onchocerca volvulus 0.0139 0.1356 0.3596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0443 0.063
Echinococcus granulosus g protein coupled receptor 0.0015 0.0008 0.0008
Schistosoma mansoni lipoxygenase 0.0464 0.4897 0.6399
Leishmania major DNA polymerase kappa, putative 0.0019 0.0051 0.016
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0468 0.4948 0.7036
Loa Loa (eye worm) hypothetical protein 0.0139 0.1356 0.1928
Schistosoma mansoni carbonic anhydrase-related 0.0055 0.0443 0.0569
Loa Loa (eye worm) hypothetical protein 0.0064 0.0544 0.0773
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0619 0.1839
Mycobacterium leprae Conserved hypothetical protein 0.0029 0.0164 0.0164
Chlamydia trachomatis dihydrofolate reductase 0.0344 0.3593 1
Brugia malayi steroid hormone receptor 0.0304 0.3154 0.4485
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0143 0.1408 0.1558
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0056 0.0457 0.0588
Plasmodium vivax amine transporter, putative 0.0056 0.0457 0.3067
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0139 0.1356 0.1764
Brugia malayi RNA binding protein 0.0066 0.0568 0.0808
Brugia malayi Nuclear hormone receptor-like 1 0.0304 0.3154 0.4485
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0326 0.3397 0.3762
Brugia malayi Protein kinase c protein 2 0.0057 0.0465 0.0661
Brugia malayi nuclear receptor NHR-88 0.0143 0.1408 0.2002
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.3138 1
Loa Loa (eye worm) hypothetical protein 0.0304 0.3154 0.4485
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0015 0.0008 0.0008
Onchocerca volvulus Dual oxidase homolog 0.0102 0.096 0.2545
Loa Loa (eye worm) hypothetical protein 0.0029 0.0162 0.023
Echinococcus granulosus tar DNA binding protein 0.0066 0.0568 0.0629
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0139 0.1356 0.1928
Echinococcus multilocularis sodium and chloride dependent glycine 0.0056 0.0457 0.0505
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0304 0.3154 0.3493
Loa Loa (eye worm) hypothetical protein 0.0091 0.0835 0.1187
Echinococcus granulosus serotonin receptor 0.0015 0.0008 0.0008
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0401 0.057
Onchocerca volvulus 0.0019 0.005 0.0131
Echinococcus granulosus peroxidasin 0.0102 0.096 0.1062
Schistosoma mansoni polycystin 1-related 0.014 0.1377 0.1791
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0287 0.0365
Loa Loa (eye worm) hypothetical protein 0.0056 0.0457 0.065
Loa Loa (eye worm) hypothetical protein 0.0139 0.1356 0.1928
Plasmodium vivax hypothetical protein, conserved 0.0056 0.0457 0.3067
Loa Loa (eye worm) hypothetical protein 0.0064 0.0544 0.0773
Echinococcus multilocularis Polycystic kidney disease protein 0.014 0.1377 0.1524
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0401 0.0443
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.005 0.0212
Brugia malayi small heat shock protein 0.066 0.7032 1
Brugia malayi hypothetical protein 0.0181 0.182 0.2588
Echinococcus multilocularis sex peptide receptor 0.0015 0.0008 0.0008
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.025 0.0355
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.3138 1
Brugia malayi neuropeptide F receptor 0.0015 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0139 0.1356 0.1928
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0132 0.128 0.4077
Loa Loa (eye worm) hypothetical protein 0.0026 0.0132 0.0187
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0568 0.0733
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0064 0.0547 0.0705
Echinococcus multilocularis carbonic anhydrase 0.0055 0.0443 0.049
Brugia malayi Cathepsin L-like precursor 0.0019 0.005 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.0072
Brugia malayi ORL1-like opioid receptor 0.0015 0.0008 0.0011
Schistosoma mansoni lipoxygenase 0.0716 0.7648 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0056 0.046 0.0591
Brugia malayi G-protein coupled receptor 0.0015 0.0008 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.005 0.0212
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.005 0.0055
Brugia malayi hypothetical protein 0.0143 0.1408 0.2002
Onchocerca volvulus 0.0015 0.0008 0.0019
Echinococcus granulosus ecdysone induced protein 78C 0.0304 0.3154 0.3493
Echinococcus multilocularis nAChR subunit 0.0075 0.066 0.0731
Schistosoma mansoni netrin receptor unc5 0.0064 0.0541 0.0698
Onchocerca volvulus 0.0139 0.1356 0.3596
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0304 0.3154 0.3493
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0029 0.0164 0.0114
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0401 0.057
Loa Loa (eye worm) hypothetical protein 0.0435 0.4582 0.6516
Brugia malayi excitatory GABA receptor EXP-1A 0.0139 0.1356 0.1928
Loa Loa (eye worm) hypothetical protein 0.0143 0.1408 0.2002
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0139 0.1356 0.1501
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Echinococcus multilocularis neuropeptide Y receptor 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0143 0.1408 0.2002
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0102 0.0956 0.136
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0143 0.1408 0.1832
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0056 0.0457 0.0505
Loa Loa (eye worm) hypothetical protein 0.0055 0.0446 0.0634
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0029 0.0164 0.0367
Onchocerca volvulus 0.0015 0.0008 0.0019
Leishmania major cysteine peptidase A (CPA) 0.0019 0.005 0.0158
Entamoeba histolytica hypothetical protein 0.015 0.1483 1
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0619 0.197
Onchocerca volvulus Peroxidasin homolog 0.0102 0.096 0.2545
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0029 0.0164 0.0114
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0075 0.066 0.0854
Brugia malayi hypothetical protein 0.0015 0.0008 0.0011
Echinococcus multilocularis lamin dm0 0.0026 0.0132 0.0145
Plasmodium vivax SET domain protein, putative 0.0029 0.0162 0.0842
Schistosoma mansoni RAR-like nuclear receptor 0.0304 0.3154 0.4118
Schistosoma mansoni hypothetical protein 0.0034 0.0218 0.0275
Echinococcus multilocularis carbonic anhydrase 0.0055 0.0443 0.049
Loa Loa (eye worm) hypothetical protein 0.0143 0.1408 0.2002
Echinococcus multilocularis nAChR subunit 0.0139 0.1356 0.1501
Onchocerca volvulus 0.0064 0.0544 0.144
Echinococcus granulosus G protein coupled receptor 139 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0143 0.1408 0.2002
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0056 0.0457 0.0505
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0716 0.7648 0.847
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.1017 0.1447
Loa Loa (eye worm) ShTK domain-containing protein 0.0091 0.0835 0.1187
Echinococcus multilocularis allatostatin A receptor 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0064 0.0544 0.0773
Brugia malayi hypothetical protein 0.0015 0.0008 0.0011
Echinococcus granulosus allatostatin A receptor 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0102 0.096 0.1365
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0049 0.0385 0.0548
Schistosoma mansoni survival motor neuron protein 0.0102 0.0956 0.1241
Loa Loa (eye worm) hypothetical protein 0.0075 0.066 0.0939
Loa Loa (eye worm) hypothetical protein 0.0304 0.3154 0.4485
Onchocerca volvulus 0.014 0.1377 0.3651
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0304 0.3154 0.3493
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0132 0.0187
Echinococcus granulosus Nuclear hormone receptor HR96 0.0143 0.1408 0.1558
Schistosoma mansoni carbonic anhydrase-related 0.0055 0.0443 0.0569
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0287 0.0365
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.1017 0.1447
Treponema pallidum sodium- and chloride- dependent transporter 0.033 0.3436 0.5
Loa Loa (eye worm) hypothetical protein 0.0545 0.5784 0.8226
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0843 0.9029 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0051 0.016
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0029 0.0164 0.0114
Echinococcus multilocularis peroxidasin 0.0102 0.096 0.1062
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0015 0.0008 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.005 0.0212
Loa Loa (eye worm) hypothetical protein 0.0609 0.6479 0.9215
Brugia malayi hypothetical protein 0.0015 0.0008 0.0011
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.005 0.0158
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.051 0.0656
Echinococcus granulosus g protein coupled receptor 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.016 0.1595 0.2268
Schistosoma mansoni sodium/chloride dependent transporter 0.033 0.3436 0.4487
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0015 0.0008 0.0008
Brugia malayi Cytochrome P450 family protein 0.0047 0.0356 0.0506
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0143 0.1408 0.1558
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0304 0.3154 0.4118
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0064 0.0541 0.0769
Brugia malayi hypothetical protein 0.036 0.3769 0.536
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0015 0.0008 0.0011
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0056 0.0457 0.3308
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.0454 0.1444
Brugia malayi Dihydrofolate reductase 0.0344 0.3593 0.511
Echinococcus granulosus g-protein coupled receptor 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0102 0.096 0.1365
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0139 0.1356 0.1928
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Echinococcus granulosus tm gpcr rhodopsin 0.0015 0.0008 0.0008
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0139 0.1356 0.1928
Brugia malayi Dopamine receptor 0.0015 0.0008 0.0011
Schistosoma mansoni thyroid hormone receptor 0.043 0.4525 0.5913
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Brugia malayi nuclear hormone receptor family member nhr-6 0.0143 0.1408 0.2002
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0139 0.1356 0.1764
Onchocerca volvulus Netrin receptor homolog 0.0064 0.0541 0.1433
Onchocerca volvulus 0.0015 0.0008 0.0019
Loa Loa (eye worm) GABA receptor subunit 0.0075 0.066 0.0939
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0139 0.1356 0.1501
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Loa Loa (eye worm) G-protein coupled receptor 0.0015 0.0008 0.0011
Echinococcus granulosus intermediate filament protein 0.0026 0.0132 0.0145
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0139 0.1356 0.1928
Brugia malayi G protein-coupled receptor 0.0015 0.0008 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.005 0.0212
Echinococcus granulosus tm gpcr rhodopsin 0.0843 0.9029 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0029 0.0164 0.0114
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0162 0.0179
Brugia malayi hypothetical protein 0.015 0.1483 0.2109
Loa Loa (eye worm) hypothetical protein 0.0102 0.096 0.1365
Loa Loa (eye worm) ctsf protein 0.0019 0.005 0.0072
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0015 0.0008 0.0008
Leishmania major cathepsin L-like protease 0.0071 0.0619 0.197
Brugia malayi Protein kinase domain containing protein 0.0064 0.0543 0.0773
Onchocerca volvulus 0.0102 0.096 0.2545
Plasmodium falciparum LCCL domain-containing protein 0.014 0.1377 1
Schistosoma mansoni tyrosinase precursor 0.0091 0.0835 0.1082
Brugia malayi Animal haem peroxidase family protein 0.0102 0.096 0.1365
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0056 0.0457 0.0505
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0311 0.0988
Echinococcus granulosus neuropeptide receptor A26 0.0015 0.0008 0.0008
Onchocerca volvulus 0.0019 0.005 0.0131
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.015 0.1483 0.1642
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0008 0.0008
Brugia malayi hypothetical protein 0.0015 0.0008 0.0011
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0132 0.0187
Leishmania major cytochrome p450-like protein 0.0029 0.0164 0.0522
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0304 0.3154 0.4485
Mycobacterium leprae putative cytochrome p450 0.0029 0.0164 0.0164
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0015 0.0008 0.0008
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0029 0.0164 0.0114
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0218 0.0241
Onchocerca volvulus Chorion peroxidase homolog 0.0102 0.096 0.2545
Brugia malayi cytochrome P450 0.0029 0.0164 0.0234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.005 0.0212
Mycobacterium ulcerans hypothetical protein 0.0159 0.1581 0.1538
Onchocerca volvulus 0.0019 0.005 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0304 0.3154 0.4485
Brugia malayi G protein-coupled receptor F59B2.13 0.0015 0.0008 0.0011
Onchocerca volvulus 0.0029 0.0162 0.0428
Brugia malayi hypothetical protein 0.016 0.1595 0.2268
Schistosoma mansoni coup transcription factor 0.0304 0.3154 0.4118
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0344 0.3593 0.356
Loa Loa (eye worm) hypothetical protein 0.016 0.1595 0.2268
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0139 0.1356 0.1501
Echinococcus granulosus 7TM GPCR rhodopsin 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Brugia malayi hypothetical protein 0.0015 0.0008 0.0011
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.0619 0.197
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.024 0.2458 0.7832
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.024 0.2458 0.3496
Loa Loa (eye worm) DR-78 0.0143 0.1408 0.2002
Onchocerca volvulus 0.0015 0.0008 0.0019
Schistosoma mansoni atypical protein kinase C 0.0018 0.004 0.0042
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0051 0.016
Echinococcus multilocularis lipoxygenase domain containing protein 0.014 0.1377 0.1524
Loa Loa (eye worm) blistered cuticle protein 3 0.0102 0.096 0.1365
Brugia malayi putative neuropeptide receptor NPR1 0.0015 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Loa Loa (eye worm) cytochrome P450 family protein 0.011 0.1044 0.1484
Loa Loa (eye worm) animal heme peroxidase 0.0102 0.096 0.1365
Leishmania major cathepsin L-like protease 0.0019 0.005 0.0158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.005 0.0212
Loa Loa (eye worm) hypothetical protein 0.0139 0.1356 0.1928
Loa Loa (eye worm) nuclear receptor NHR-67 0.0143 0.1408 0.2002
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0029 0.0164 0.0114
Loa Loa (eye worm) hypothetical protein 0.0143 0.1408 0.2002
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0098 0.092 0.1018
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0029 0.0164 0.0114
Schistosoma mansoni hypothetical protein 0.0373 0.3906 0.5102
Onchocerca volvulus 0.0019 0.005 0.0131
Onchocerca volvulus 0.036 0.3769 1
Loa Loa (eye worm) dihydrofolate reductase 0.0344 0.3593 0.511
Brugia malayi Common central domain of tyrosinase family protein 0.0091 0.0835 0.1187
Brugia malayi Tachykinin-like peptides receptor 99D 0.0015 0.0008 0.0011
Schistosoma mansoni nuclear receptor 0.0143 0.1408 0.1832
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.016 0.1595 0.1765
Schistosoma mansoni neurotransmitter gated ion channel 0.0064 0.0544 0.0701
Loa Loa (eye worm) hypothetical protein 0.0102 0.096 0.1365
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0143 0.1408 0.1558
Echinococcus granulosus glycine receptor subunit beta 0.0139 0.1356 0.1501
Echinococcus granulosus carbonic anhydrase 0.0055 0.0443 0.049
Brugia malayi hypothetical protein 0.0143 0.1408 0.2002
Echinococcus multilocularis conserved hypothetical protein 0.0667 0.7106 0.787
Leishmania major cathepsin L-like protease 0.0019 0.005 0.0158
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0401 0.0443
Loa Loa (eye worm) hypothetical protein 0.0064 0.0544 0.0773
Echinococcus multilocularis FTZ F1 alpha 0.0304 0.3154 0.3493
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Leishmania major cathepsin L-like protease 0.0019 0.005 0.0158
Echinococcus multilocularis neuropeptides capa receptor 0.0015 0.0008 0.0008
Schistosoma mansoni sodium/chloride dependent transporter 0.0056 0.0457 0.0588
Entamoeba histolytica hypothetical protein 0.0075 0.066 0.4257
Loa Loa (eye worm) hypothetical protein 0.0055 0.0443 0.063
Brugia malayi Nuclear hormone receptor-like 1 0.016 0.1595 0.2268
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0056 0.0457 0.0588
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0139 0.1356 0.1501
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0619 0.197
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0139 0.1356 0.1928
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0008 0.0008
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0139 0.1356 0.1501
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Brugia malayi ShTK domain containing protein 0.0091 0.0835 0.1187
Brugia malayi Blistered cuticle protein 3 0.0102 0.096 0.1365
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0029 0.0164 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.005 0.0212
Echinococcus granulosus neuropeptide Y receptor 0.0015 0.0008 0.0008
Brugia malayi ecdysteroid receptor 0.0304 0.3154 0.4485
Echinococcus granulosus netrin receptor unc 5 0.0064 0.0541 0.0598
Loa Loa (eye worm) hypothetical protein 0.0056 0.0457 0.065
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.005 0.0072
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.1219 0.135
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0162 0.0908
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0401 0.0514
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0304 0.3154 0.3493
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.005 0.0212
Loa Loa (eye worm) hypothetical protein 0.0075 0.066 0.0939
Loa Loa (eye worm) hypothetical protein 0.0075 0.066 0.0939
Schistosoma mansoni peroxidasin 0.0102 0.096 0.1246
Loa Loa (eye worm) hypothetical protein 0.0139 0.1356 0.1928
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0139 0.1356 0.1928
Loa Loa (eye worm) hypothetical protein 0.0102 0.096 0.1365
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0056 0.0457 0.065
Schistosoma mansoni nAChR subunit 0.0139 0.1356 0.1764
Loa Loa (eye worm) hypothetical protein 0.0139 0.1356 0.1928
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0051 0.016
Loa Loa (eye worm) hypothetical protein 0.0139 0.1356 0.1928
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0132 0.128 1
Loa Loa (eye worm) hypothetical protein 0.0143 0.1408 0.2002
Brugia malayi Doublecortin family protein 0.014 0.1377 0.1958
Plasmodium falciparum carbonic anhydrase 0.0055 0.0443 0.2961
Onchocerca volvulus 0.0075 0.066 0.175
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0304 0.3154 0.3493
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0015 0.0008 0.0008
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0139 0.1356 0.1501
Echinococcus granulosus peptide allatostatin:somatostatin 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0446 0.4705 0.6691
Loa Loa (eye worm) hypothetical protein 0.0304 0.3154 0.4485
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0139 0.1356 0.1928
Echinococcus multilocularis neuropeptides capa receptor 0.0015 0.0008 0.0008
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0223 0.0952
Schistosoma mansoni tyrosinase precursor 0.0091 0.0835 0.1082
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0029 0.0164 0.0114
Onchocerca volvulus 0.0015 0.0008 0.0019
Onchocerca volvulus 0.0139 0.1356 0.3596
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0139 0.1356 0.1501
Schistosoma mansoni lamin 0.0026 0.0132 0.0162
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.051 0.0563
Loa Loa (eye worm) hypothetical protein 0.0139 0.1356 0.1928
Echinococcus multilocularis glycine receptor subunit beta 0.0139 0.1356 0.1501
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0304 0.3154 0.3493
Onchocerca volvulus 0.0102 0.096 0.2545
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0048 0.0366 0.0405
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.005 0.0055
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0015 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0304 0.3154 0.4485
Brugia malayi Pre-SET motif family protein 0.0029 0.0162 0.023
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Entamoeba histolytica hypothetical protein 0.015 0.1483 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.1356 0.1928
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0056 0.0457 0.065
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0139 0.1356 0.1928
Echinococcus granulosus Protein kinase C brain isozyme 0.0067 0.0575 0.0636
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0015 0.0008 0.0011
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0029 0.0164 0.0114
Echinococcus multilocularis neuropeptide s receptor 0.0015 0.0008 0.0008
Brugia malayi Cation transporter family protein 0.0139 0.1356 0.1928
Echinococcus granulosus nAChR subunit 0.0075 0.066 0.0731
Brugia malayi hypothetical protein 0.0015 0.0008 0.0011
Echinococcus granulosus sodium and chloride dependent glycine 0.0056 0.0457 0.0505
Onchocerca volvulus Peroxidase homolog 0.0102 0.096 0.2545
Brugia malayi Cathepsin L-like precursor 0.0019 0.005 0.0072
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0139 0.1356 0.1501
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Onchocerca volvulus Bile acid receptor homolog 0.0304 0.3154 0.8367
Schistosoma mansoni nuclear receptor nhr-48 0.0143 0.1408 0.1832
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0029 0.0164 0.0114
Onchocerca volvulus 0.0056 0.0457 0.1211
Loa Loa (eye worm) hypothetical protein 0.0102 0.096 0.1365
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0051 0.0056
Loa Loa (eye worm) neuropeptide F receptor 0.0015 0.0008 0.0011
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0139 0.1356 0.1764
Schistosoma mansoni nAChR subunit 0.0139 0.1356 0.1764
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0162 0.0202
Echinococcus multilocularis g protein coupled receptor 0.0015 0.0008 0.0008
Loa Loa (eye worm) animal heme peroxidase 0.0102 0.096 0.1365
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0619 0.1839
Brugia malayi hypothetical protein 0.0015 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0098 0.092 0.1309
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0139 0.1356 0.1501
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0029 0.0164 0.0114
Brugia malayi Cathepsin L-like precursor 0.0019 0.005 0.0072
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0056 0.0457 0.0505
Loa Loa (eye worm) RNA binding protein 0.0066 0.0568 0.0808
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.005 0.0072
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0143 0.1408 0.2002
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0139 0.1356 0.1928
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0304 0.3154 0.4485
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0029 0.0164 0.0114
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0139 0.1356 0.1501
Brugia malayi Nuclear hormone receptor E75 0.0143 0.1408 0.2002
Trichomonas vaginalis set domain proteins, putative 0.0229 0.234 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0304 0.3154 0.4485
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0139 0.1356 0.1928
Onchocerca volvulus 0.014 0.1377 0.3651
Brugia malayi Putative carbonic anhydrase 5 precursor 0.024 0.2458 0.3496
Loa Loa (eye worm) hypothetical protein 0.016 0.1595 0.2268
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0015 0.0008 0.0011
Onchocerca volvulus Cathepsin L homolog 0.0019 0.005 0.0131
Echinococcus multilocularis GPCR, family 2 0.0034 0.0218 0.0241
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0015 0.0008 0.0008
Onchocerca volvulus Peroxidasin homolog 0.0102 0.096 0.2545
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0162 0.0179
Echinococcus multilocularis thyroid hormone receptor alpha 0.043 0.4525 0.5012
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0568 0.0808
Brugia malayi Cytochrome P450 family protein 0.0029 0.0164 0.0234
Loa Loa (eye worm) hypothetical protein 0.0102 0.096 0.1365
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0304 0.3154 0.4118
Loa Loa (eye worm) hypothetical protein 0.0143 0.1408 0.2002
Schistosoma mansoni nuclear receptor 0.0143 0.1408 0.1832
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0008 0.0008
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0459 0.4842 0.5362
Echinococcus granulosus serotonin transporter 0.033 0.3436 0.3805
Echinococcus granulosus sodium and chloride dependent glycine 0.0056 0.0457 0.0505
Schistosoma mansoni hypothetical protein 0.0102 0.0956 0.1241
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0003 0.0008
Toxoplasma gondii hypothetical protein 0.0055 0.0443 0.3194
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.051 0.0461
Echinococcus multilocularis dna polymerase eta 0.0019 0.0051 0.0056
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.005 0.0212
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0029 0.0164 0.0114
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0526 0.5576 0.7288
Onchocerca volvulus 0.0091 0.0835 0.2213
Loa Loa (eye worm) hypothetical protein 0.0048 0.0366 0.0521
Schistosoma mansoni cytochrome P450 0.0029 0.0164 0.0205
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0015 0.0008 0.0008
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0139 0.1356 0.1928
Onchocerca volvulus 0.0019 0.005 0.0131
Loa Loa (eye worm) hypothetical protein 0.0064 0.0544 0.0773
Onchocerca volvulus 0.0019 0.005 0.0131
Echinococcus multilocularis neuropeptide Y receptor 0.0015 0.0008 0.0008
Schistosoma mansoni rab6-interacting 0.014 0.1377 0.1791
Schistosoma mansoni lamin 0.0026 0.0132 0.0162
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0544 0.0773
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0143 0.1408 0.3733
Onchocerca volvulus 0.0075 0.066 0.175
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0056 0.0457 0.0588
Brugia malayi Melatonin receptor type 1A 0.0015 0.0008 0.0011
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0143 0.1408 0.1558
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0055 0.0443 0.063
Brugia malayi Animal haem peroxidase family protein 0.0102 0.096 0.1365
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.024 0.2458 0.3207
Onchocerca volvulus 0.0139 0.1356 0.3596
Loa Loa (eye worm) doublecortin family protein 0.014 0.1377 0.1958
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0056 0.0457 0.0505
Schistosoma mansoni hypothetical protein 0.0034 0.0218 0.0275
Schistosoma mansoni hypothetical protein 0.0347 0.3621 0.4729
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0015 0.0008 0.0011
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.005 0.0055
Echinococcus multilocularis glycine receptor subunit beta 0.0139 0.1356 0.1501
Loa Loa (eye worm) hypothetical protein 0.033 0.3436 0.4886
Onchocerca volvulus 0.0064 0.0544 0.144
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Brugia malayi Animal haem peroxidase family protein 0.0102 0.096 0.1365
Schistosoma mansoni amidase 0.0098 0.092 0.1194
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Echinococcus multilocularis serotonin receptor 0.0015 0.0008 0.0008
Leishmania major cathepsin L-like protease 0.0071 0.0619 0.197
Onchocerca volvulus 0.004 0.0283 0.0749
Entamoeba histolytica hypothetical protein 0.015 0.1483 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0453 0.4783 0.5297
Loa Loa (eye worm) hypothetical protein 0.016 0.1595 0.2268
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0003 0.0008
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0304 0.3154 0.3493
Echinococcus granulosus thyroid hormone receptor alpha 0.0143 0.1408 0.1558
Onchocerca volvulus 0.0015 0.0008 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0029 0.0164 0.0114
Loa Loa (eye worm) hypothetical protein 0.0075 0.066 0.0939
Echinococcus granulosus somatostatin receptor 0.0015 0.0008 0.0008
Onchocerca volvulus 0.0139 0.1356 0.3596
Onchocerca volvulus Cathepsin L homolog 0.0019 0.005 0.0131
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0304 0.3154 0.3493
Brugia malayi hypothetical protein 0.014 0.1377 0.1958
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0304 0.3154 0.4485
Brugia malayi Sodium:neurotransmitter symporter family protein 0.033 0.3436 0.4886
Loa Loa (eye worm) hypothetical protein 0.0143 0.1408 0.2002
Echinococcus granulosus sex peptide receptor 0.0015 0.0008 0.0008
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0056 0.0457 0.0588
Echinococcus multilocularis cysteine protease 0.0019 0.005 0.0055
Onchocerca volvulus 0.0056 0.0457 0.1211
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.0552 0.1757
Echinococcus granulosus tm gpcr rhodopsin 0.0015 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.005 0.0212
Onchocerca volvulus 0.0015 0.0008 0.0019
Schistosoma mansoni ankyrin 23/unc44 0.0064 0.0541 0.0698
Loa Loa (eye worm) hypothetical protein 0.0102 0.096 0.1365
Onchocerca volvulus Cathepsin F homolog 0.0019 0.005 0.0131
Onchocerca volvulus 0.0026 0.0132 0.0347
Brugia malayi follicle stimulating hormone receptor 0.0468 0.4948 0.7036
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0019 0.0056 0.008
Schistosoma mansoni nAChR subunit 0.0064 0.0544 0.0701
Loa Loa (eye worm) LGC-31 protein 0.0139 0.1356 0.1928
Echinococcus granulosus dna polymerase kappa 0.0019 0.0051 0.0056
Loa Loa (eye worm) hypothetical protein 0.0304 0.3154 0.4485
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.2037 0.2897
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0139 0.1356 0.1928
Leishmania major cathepsin L-like protease 0.0071 0.0619 0.197
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0401 0.0514
Loa Loa (eye worm) ShTK domain-containing protein 0.0091 0.0835 0.1187
Echinococcus granulosus neuropeptides capa receptor 0.0015 0.0008 0.0008
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.005 0.0055
Echinococcus granulosus nAChR subunit 0.0139 0.1356 0.1501
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1405 0.4476
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0029 0.0164 0.0114
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0056 0.0457 0.127
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1405 0.4476
Loa Loa (eye worm) hypothetical protein 0.0143 0.1408 0.2002
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0015 0.0008 0.0008
Trypanosoma brucei cytochrome P450, putative 0.0047 0.0356 0.0987
Loa Loa (eye worm) hypothetical protein 0.0499 0.5281 0.751
Loa Loa (eye worm) hypothetical protein 0.0139 0.1356 0.1928
Echinococcus granulosus single minded 2 0.0043 0.032 0.0354
Schistosoma mansoni loxhd1 0.014 0.1377 0.1791
Schistosoma mansoni hypothetical protein 0.0064 0.0541 0.0698
Schistosoma mansoni nuclear hormone receptor 0.0304 0.3154 0.4118
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0029 0.0164 0.0114
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0304 0.3154 0.4485
Brugia malayi tailless protein 0.0143 0.1408 0.2002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0304 0.3154 0.4485
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.015 0.0166
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0029 0.0164 0.0522
Loa Loa (eye worm) hypothetical protein 0.0304 0.3154 0.4485
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0139 0.1356 0.1501
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0064 0.0544 0.0773
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Loa Loa (eye worm) CYP4Cod1 0.0047 0.0356 0.0506
Loa Loa (eye worm) tyrosinase 1 0.0091 0.0835 0.1187
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0056 0.0457 0.0588
Schistosoma mansoni jun-related protein 0.0373 0.3906 0.5102
Brugia malayi nuclear receptor RXR 0.016 0.1595 0.2268
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.051 0.3734
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0304 0.3154 0.4485
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Schistosoma mansoni thyroid hormone receptor 0.043 0.4525 0.5913
Brugia malayi intermediate filament protein 0.0026 0.0132 0.0187
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0064 0.0544 0.0601
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0029 0.0164 0.0114
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0609 0.6479 0.9215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.005 0.0212
Loa Loa (eye worm) hypothetical protein 0.0143 0.1408 0.2002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0619 0.1839
Leishmania major cathepsin L-like protease 0.0019 0.005 0.0158
Loa Loa (eye worm) hypothetical protein 0.0055 0.0443 0.063
Echinococcus multilocularis fmrfamide receptor 0.0015 0.0008 0.0008
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0139 0.1356 0.1928
Loa Loa (eye worm) hypothetical protein 0.0139 0.1356 0.1928
Schistosoma mansoni nAChR subunit 0.0139 0.1356 0.1764
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0932 1 1
Loa Loa (eye worm) norepinephrine transporter 0.033 0.3436 0.4886
Echinococcus granulosus fmrfamide receptor 0.0015 0.0008 0.0008
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0075 0.066 0.0939
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0304 0.3154 0.4485
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0139 0.1356 0.1928
Schistosoma mansoni carbonic anhydrase-related 0.0055 0.0443 0.0569
Schistosoma mansoni dihydrofolate reductase 0.0344 0.3593 0.4693
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0304 0.3154 0.4485
Loa Loa (eye worm) hypothetical protein 0.0139 0.1356 0.1928
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0003 0.0008
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.015 0.1483 0.1642
Onchocerca volvulus 0.0026 0.0132 0.0347
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0304 0.3154 0.3493
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0015 0.0008 0.0008
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0098 0.092 0.1018
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0568 0.0808
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Loa Loa (eye worm) G-protein coupled receptor 0.0015 0.0008 0.0011
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0003 0.0008
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.005 0.0055
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.005 0.0055
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Echinococcus granulosus cytochrome P450 2K1 0.0029 0.0164 0.0181
Brugia malayi sulfakinin receptor protein 0.0015 0.0008 0.0011
Plasmodium vivax multidomain scavenger receptor, putative 0.014 0.1377 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0164 0.0522
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0015 0.0008 0.0008
Echinococcus multilocularis G protein coupled receptor 139 0.0015 0.0008 0.0008
Loa Loa (eye worm) animal heme peroxidase 0.0102 0.096 0.1365
Brugia malayi Dopamine receptor protein 1 0.0015 0.0008 0.0011
Leishmania major cytochrome p450-like protein 0.0029 0.0164 0.0522
Loa Loa (eye worm) hypothetical protein 0.0026 0.0127 0.018
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0056 0.0457 0.065
Onchocerca volvulus 0.0304 0.3154 0.8367
Echinococcus multilocularis ecdysone induced protein 78C 0.0304 0.3154 0.3493
Echinococcus multilocularis neuropeptide receptor 0.0015 0.0008 0.0008
Echinococcus multilocularis lipoxygenase domain containing protein 0.014 0.1377 0.1524
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0051 0.0005
Echinococcus granulosus fatty acid amide hydrolase 1 0.0098 0.092 0.1018
Echinococcus granulosus nuclear factor of activated T cells 5 0.0326 0.3397 0.3762
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0568 0.0733
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Echinococcus granulosus glycine receptor subunit alpha 1 0.0139 0.1356 0.1501
Echinococcus granulosus dna polymerase eta 0.0019 0.0051 0.0056
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Brugia malayi dihydrofolate reductase family protein 0.0344 0.3593 0.511
Loa Loa (eye worm) hypothetical protein 0.0075 0.066 0.0939
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0051 0.0073
Echinococcus granulosus protein kinase c epsilon type 0.0019 0.0056 0.0062
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0344 0.3593 0.356
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0311 0.0841
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0139 0.1356 0.1501
Schistosoma mansoni single-minded 0.0054 0.0436 0.056
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0055 0.0443 0.063
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0056 0.0457 0.065
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0064 0.0541 0.0598
Schistosoma mansoni aryl hydrocarbon receptor 0.0054 0.0436 0.056
Echinococcus granulosus Nuclear hormone receptor HR96 0.0143 0.1408 0.1558
Echinococcus multilocularis dro:myosuppressin receptor 0.0015 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0347 0.3621 0.4729
Echinococcus granulosus protein kinase C gamma type 0.0059 0.0495 0.0548
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0029 0.0164 0.0114
Echinococcus granulosus FTZ F1 alpha 0.0304 0.3154 0.3493
Brugia malayi Cytochrome P450 family protein 0.0047 0.0356 0.0506
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.3138 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0073
Onchocerca volvulus 0.0064 0.0544 0.144
Echinococcus granulosus neuropeptide Y receptor 0.0015 0.0008 0.0008
Echinococcus multilocularis neuropeptide receptor A26 0.0015 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.005 0.0212
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0132 0.128 0.9272
Brugia malayi Cation transporter family protein 0.0139 0.1356 0.1928
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0029 0.0164 0.0114
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.025 0.0276
Brugia malayi Cation transporter family protein 0.0139 0.1356 0.1928
Brugia malayi Steroid receptor seven-up type 2 0.0304 0.3154 0.4485
Leishmania major cathepsin L-like protease 0.0019 0.005 0.0158
Brugia malayi RE15519p 0.0015 0.0008 0.0011
Echinococcus granulosus carbonic anhydrase II 0.024 0.2458 0.2722
Echinococcus multilocularis somatostatin receptor 0.0015 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0304 0.3154 0.4485
Giardia lamblia DINP protein human, muc B family 0.0019 0.0051 0.5
Loa Loa (eye worm) hypothetical protein 0.0102 0.096 0.1365
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0283 0.0313
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0716 0.7648 0.847
Brugia malayi hypothetical protein 0.0064 0.0544 0.0773
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0064 0.0544 0.0601
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0008 0.0008
Echinococcus granulosus glycine receptor subunit alpha 1 0.0139 0.1356 0.1501
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0051 0.0215
Toxoplasma gondii cytochrome p450 superfamily protein 0.0029 0.0164 0.0928
Loa Loa (eye worm) hypothetical protein 0.0181 0.182 0.2588
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0143 0.1408 0.1558
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.3138 1
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0575 0.0742
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0008 0.0008
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0051 0.0056
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0055 0.0443 0.063
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0015 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0139 0.1356 0.1928
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0051 0.016
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0132 0.128 0.4077
Schistosoma mansoni rab6-interacting 0.014 0.1377 0.1791
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0304 0.3154 0.4485
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0015 0.0008 0.0011
Onchocerca volvulus 0.0015 0.0008 0.0019
Schistosoma mansoni transcription factor LCR-F1 0.015 0.1483 0.1931
Brugia malayi AKH receptor 0.0015 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0064 0.0544 0.0773
Brugia malayi orphan nuclear receptor NR2E1 0.0143 0.1408 0.2002
Onchocerca volvulus 0.0091 0.0835 0.2213
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0055 0.0443 0.063
Onchocerca volvulus 0.0091 0.0835 0.2213
Onchocerca volvulus 0.0143 0.1408 0.3733
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0008 0.0008
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0015 0.0008 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0619 0.1839
Schistosoma mansoni nAChR subunit 0.0139 0.1356 0.1764
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0568 0.0733
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0051 0.016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.005 0.0212
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.1017 0.1447
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0218 0.031
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0568 0.0733
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0029 0.0164 0.0114
Brugia malayi Cytochrome P450 family protein 0.011 0.1044 0.1484
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0139 0.1356 0.1501
Echinococcus granulosus dihydrofolate reductase 0.0344 0.3593 0.3979
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0067 0.0575 0.0636
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.1581 0.1538
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0568 0.0733
Loa Loa (eye worm) hypothetical protein 0.0102 0.096 0.1365
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0051 0.0073
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0304 0.3154 0.4118
Echinococcus granulosus carbonic anhydrase 0.0055 0.0443 0.049
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0056 0.0457 0.0588
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0162 0.0202
Loa Loa (eye worm) melatonin receptor type 1A 0.0015 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0102 0.096 0.1365
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Brugia malayi bHLH-PAS transcription factor 0.004 0.0283 0.0403
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0015 0.0008 0.0008
Loa Loa (eye worm) solute carrier family 6 member 4 0.033 0.3436 0.4886
Loa Loa (eye worm) hypothetical protein 0.0064 0.0544 0.0773
Brugia malayi nuclear receptor RXR 0.0143 0.1408 0.2002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.005 0.0212
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0459 0.4842 0.5362
Brugia malayi Immunoglobulin I-set domain containing protein 0.0064 0.0541 0.0769
Loa Loa (eye worm) hypothetical protein 0.0075 0.066 0.0939
Schistosoma mansoni nAChR subunit 0.0139 0.1356 0.1764
Loa Loa (eye worm) neuropeptide F receptor 0.0015 0.0008 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.005 0.0212
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0218 0.031
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0029 0.0164 0.0522
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0029 0.0164 0.0114
Leishmania major carbonic anhydrase-like protein 0.024 0.2458 0.7832
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.005 0.0212
Schistosoma mansoni hypothetical protein 0.0029 0.0164 0.0205
Echinococcus multilocularis nuclear receptor nhr 48 0.0143 0.1408 0.1558
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0619 0.1839
Echinococcus multilocularis dihydrofolate reductase 0.0344 0.3593 0.3979
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0029 0.0164 0.0114
Loa Loa (eye worm) hypothetical protein 0.0143 0.1408 0.2002
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.016 0.1595 0.2268
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0064 0.0544 0.0601
Echinococcus granulosus dro:myosuppressin receptor 0.0015 0.0008 0.0008
Brugia malayi Nuclear hormone receptor-like 1 0.016 0.1595 0.2268
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0075 0.066 0.0854
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0029 0.0164 0.0114
Echinococcus multilocularis serine threonine protein kinase 0.0059 0.0495 0.0548
Echinococcus granulosus RUN 0.014 0.1377 0.1524
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0029 0.0164 0.0114
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0029 0.0164 0.0114
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0401 0.0443
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.0835 0.1187
Echinococcus multilocularis neuropeptide FF receptor 2 0.0015 0.0008 0.0008
Echinococcus multilocularis protein kinase c epsilon type 0.0019 0.0056 0.0062
Brugia malayi hypothetical protein 0.0064 0.0544 0.0773
Echinococcus multilocularis carbonic anhydrase 0.0055 0.0443 0.049
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0304 0.3154 0.4118
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0008 0.0008
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0029 0.0164 0.0114
Echinococcus multilocularis protein kinase c iota type 0.0018 0.004 0.0043
Schistosoma mansoni acetylcholine receptor subunit beta 0.0064 0.0544 0.0701
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.024 0.2458 0.7832
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Echinococcus granulosus fatty acid amide hydrolase 1 0.0098 0.092 0.1018
Schistosoma mansoni DNA polymerase eta 0.0019 0.0051 0.0056
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0051 0.0056
Echinococcus multilocularis orexin receptor type 2 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0304 0.3154 0.3493
Loa Loa (eye worm) hypothetical protein 0.0064 0.0544 0.0773
Echinococcus granulosus death domain containing protein 0.0064 0.0541 0.0598
Entamoeba histolytica hypothetical protein 0.015 0.1483 1
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0056 0.0063
Echinococcus multilocularis RNA directed DNA polymerase 0.0048 0.0366 0.0405
Brugia malayi ecdysone receptor 0.0143 0.1408 0.2002
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0412 0.131
Brugia malayi Nuclear hormone receptor E75 0.0143 0.1408 0.2002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0218 0.0241
Echinococcus multilocularis 0.0029 0.0164 0.0181
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0304 0.3154 0.4118
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0139 0.1356 0.1928
Schistosoma mansoni nAChR subunit 0.0139 0.1356 0.1764
Echinococcus granulosus neuropeptides capa receptor 0.0015 0.0008 0.0008
Echinococcus granulosus biogenic amine 5HT receptor 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Brugia malayi conserved hypotetical protein 0.0143 0.1408 0.2002
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0029 0.0164 0.0114
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0015 0.0008 0.0008
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0064 0.0544 0.0773
Brugia malayi Dopamine receptor protein 2 0.0015 0.0008 0.0011
Schistosoma mansoni hypothetical protein 0.0055 0.0443 0.0569
Onchocerca volvulus 0.0015 0.0008 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0056
Loa Loa (eye worm) hypothetical protein 0.0091 0.0835 0.1187
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.051 0.0461
Echinococcus granulosus neuropeptide s receptor 0.0015 0.0008 0.0008
Brugia malayi nuclear receptor NHR-67 0.0143 0.1408 0.2002
Brugia malayi hypoxia-induced factor 1 0.0167 0.1667 0.2371
Echinococcus granulosus hypothetical protein 0.0681 0.7266 0.8048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.005 0.0212
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0047 0.0356 0.0306
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0568 0.0808
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0075 0.066 0.0939
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0139 0.1356 0.1501
Onchocerca volvulus 0.0019 0.005 0.0131
Brugia malayi GnHR receptor homolog 0.0015 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0107 0.1017 0.1447
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0139 0.1356 0.1764
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0056 0.0457 0.3308
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0055 0.0443 0.063
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0029 0.0164 0.0114
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Echinococcus granulosus neuropeptide receptor 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0056 0.0457 0.065
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0139 0.1356 0.1928
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0401 0.0514
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0218 0.0241
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0056 0.0457 0.3308
Brugia malayi nuclear receptor NHR-88 0.0304 0.3154 0.4485
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Brugia malayi photoreceptor-specific nuclear receptor 0.0304 0.3154 0.4485
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.005 0.0212
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Echinococcus granulosus Ankyrin 0.0064 0.0547 0.0605
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0143 0.1408 0.2002
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0064 0.0544 0.0601
Brugia malayi hypothetical protein 0.016 0.1595 0.2268
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0051 0.0056
Toxoplasma gondii hypothetical protein 0.0049 0.0379 0.267
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.024 0.2458 0.3207
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Echinococcus granulosus Polycystic kidney disease protein 0.014 0.1377 0.1524
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.005 0.0212
Loa Loa (eye worm) hypothetical protein 0.0064 0.0544 0.0773
Plasmodium falciparum transporter, putative 0.0056 0.0457 0.3067
Echinococcus granulosus protein kinase c iota type 0.0018 0.004 0.0043
Loa Loa (eye worm) hypothetical protein 0.0075 0.066 0.0939
Loa Loa (eye worm) animal heme peroxidase 0.0102 0.096 0.1365
Loa Loa (eye worm) hypothetical protein 0.0102 0.096 0.1365
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0139 0.1356 0.1928
Echinococcus multilocularis netrin receptor unc 5 0.0064 0.0541 0.0598
Echinococcus granulosus tachykinin peptides receptor 99D 0.0015 0.0008 0.0008
Onchocerca volvulus 0.0015 0.0008 0.0019
Echinococcus granulosus g protein coupled receptor 0.0015 0.0008 0.0008
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.0835 0.1187
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0056 0.0457 0.065
Echinococcus granulosus lipoxygenase domain containing protein 0.014 0.1377 0.1524
Brugia malayi PAS domain containing protein 0.0054 0.0436 0.062
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0132 0.0187
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.016 0.1595 0.1765
Schistosoma mansoni steroid hormone receptor ad4bp 0.0304 0.3154 0.4118
Brugia malayi amidase 0.0098 0.092 0.1309
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.016 0.1595 0.2077
Schistosoma mansoni nAChR subunit 0.0064 0.0544 0.0701
Brugia malayi larval opioid receptor 0.0015 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0064 0.0544 0.0773
Loa Loa (eye worm) serotonin transporter b 0.033 0.3436 0.4886
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.005 0.0212
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0575 0.0742
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0647 0.092
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0011
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0029 0.0164 0.0114
Echinococcus granulosus carbonic anhydrase 0.0055 0.0443 0.049
Loa Loa (eye worm) hypothetical protein 0.0056 0.0457 0.065
Onchocerca volvulus 0.0015 0.0008 0.0019
Echinococcus granulosus nuclear receptor nhr 48 0.0143 0.1408 0.1558
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0051 0.016
Echinococcus granulosus neuropeptide FF receptor 2 0.0015 0.0008 0.0008
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.005 0.0055
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0139 0.1356 0.1928
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0139 0.1356 0.1501
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0619 0.1839
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0029 0.0164 0.0114
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0139 0.1356 0.1501
Echinococcus granulosus jun protein 0.0459 0.4842 0.5362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.005 0.0212
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0401 0.0443
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0015 0.0008 0.0008
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0015 0.0008 0.0008
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0139 0.1356 0.1928
Loa Loa (eye worm) TYRA-2 protein 0.0015 0.0008 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.005 0.0212
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.005 0.0055
Loa Loa (eye worm) hypothetical protein 0.014 0.1377 0.1958
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0029 0.0164 0.0114

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.2 uM Inhibition of rat brain protein kinase C (PKC) with ATP and histone as substrates ChEMBL. 1732526
IC50 (binding) = 1.2 uM Inhibition of rat brain protein kinase C (PKC) with ATP and histone as substrates ChEMBL. 1732526
IC50 (binding) = 82 uM Inhibition of bovine cAMP-dependent protein kinase A. ChEMBL. 1732526
Selectivity (binding) = 68 Selectivity ratio (IC50 PKA divided by IC50 PKC). ChEMBL. 1732526

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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