Detailed information for compound 833038

Basic information

Technical information
  • TDR Targets ID: 833038
  • Name: ethyl 2-[[2-(7-tert-butyl-4-oxo-5,6,7,8-tetra hydro-[1]benzothiolo[2,3-d]triazin-3-yl)acety l]amino]benzoate
  • MW: 468.569 | Formula: C24H28N4O4S
  • H donors: 1 H acceptors: 3 LogP: 6.11 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccccc1NC(=O)Cn1nnc2c(c1=O)c1CCC(Cc1s2)C(C)(C)C
  • InChi: 1S/C24H28N4O4S/c1-5-32-23(31)15-8-6-7-9-17(15)25-19(29)13-28-22(30)20-16-11-10-14(24(2,3)4)12-18(16)33-21(20)26-27-28/h6-9,14H,5,10-13H2,1-4H3,(H,25,29)
  • InChiKey: XVHVVOPXDTWZHP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-[[2-(7-tert-butyl-4-oxo-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]triazin-3-yl)acetyl]amino]benzoate
  • 2-[[2-(7-tert-butyl-4-oxo-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]triazin-3-yl)-1-oxoethyl]amino]benzoic acid ethyl ester
  • 2-[[2-(7-tert-butyl-4-keto-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]triazin-3-yl)acetyl]amino]benzoic acid ethyl ester
  • ethyl 2-[2-(7-tert-butyl-4-oxo-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d][1,2,3]triazin-3-yl)ethanoylamino]benzoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0384 0.0375
Onchocerca volvulus 0.0023 0.0082 0.0107
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0097 0.183
Schistosoma mansoni thyroid hormone receptor 0.0113 0.0643 0.2232
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.002 0.006 0.0067
Onchocerca volvulus 0.0016 0.0035 0.0035
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0113 0.0643 0.2232
Schistosoma mansoni opsin-like receptor 0.0023 0.0082 0.0286
Schistosoma mansoni amine GPCR 0.0023 0.0082 0.0286
Brugia malayi Glutamate receptor 2 precursor 0.0014 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.008 0.0437 0.0661
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0035
Echinococcus granulosus expressed conserved protein 0.0184 0.1085 0.3747
Loa Loa (eye worm) hypothetical protein 0.0379 0.2301 0.3479
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0113 0.0643 0.0972
Brugia malayi Serotonin receptor 0.0023 0.0082 0.0107
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0016 0.0035 0.0079
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0228 0.0327
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0227 0.0218
Loa Loa (eye worm) hypothetical protein 0.003 0.0123 0.0187
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0113 0.0643 0.0956
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0086 0.0477 0.1006
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0016 0.0035 0.0079
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0265 0.0599
Brugia malayi putative neuropeptide receptor 0.0023 0.0082 0.0107
Echinococcus multilocularis bloom syndrome protein 0.002 0.006 0.0051
Echinococcus granulosus g protein coupled receptor 0.0023 0.0082 0.0255
Plasmodium falciparum transporter, putative 0.008 0.0437 0.9153
Onchocerca volvulus 0.0016 0.0035 0.0035
Echinococcus granulosus GPCR family 2 0.0047 0.0228 0.0762
Schistosoma mansoni sodium/chloride dependent transporter 0.0472 0.2881 1
Brugia malayi hypothetical protein 0.0023 0.0082 0.0107
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0035 0.0121
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0097 0.0257
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0227 0.0786
Echinococcus granulosus WW domain containing oxidoreductase 0.0016 0.0035 0.0089
Loa Loa (eye worm) hypothetical protein 0.0472 0.2881 0.4356
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0113 0.0643 0.2207
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0023 0.0082 0.0073
Brugia malayi hypothetical protein 0.0023 0.0082 0.0107
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0097 0.183
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0082 0.0286
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0016 0.0035 0.0053
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0113 0.0643 0.0635
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0113 0.0643 0.0635
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0035 0.0121
Onchocerca volvulus Sepiapterin reductase homolog 0.0016 0.0035 0.0035
Echinococcus multilocularis geminin 0.0172 0.1008 0.0999
Echinococcus granulosus nibrin 0.002 0.006 0.0177
Echinococcus granulosus Niemann Pick C1 protein 0.0196 0.1159 0.4005
Echinococcus granulosus steroid dehydrogenase 0.0016 0.0035 0.0089
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0053
Echinococcus granulosus retinol dehydrogenase 11 0.0016 0.0035 0.0089
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0086 0.0477 0.1655
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0227 0.0218
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0092
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0016 0.0035 0.0079
Echinococcus multilocularis carbonyl reductase 1 0.0016 0.0035 0.0026
Schistosoma mansoni hypothetical protein 0.0023 0.0082 0.0286
Loa Loa (eye worm) oxidoreductase 0.0016 0.0035 0.0053
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0037 0.0169 0.0588
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0035 0.0079
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0035 0.0079
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0016 0.0035 0.0089
Loa Loa (eye worm) patched family protein 0.0012 0.0012 0.0018
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0082 0.0108
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0615 0.3771 0.8514
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.006 0.0067
Echinococcus granulosus G protein coupled receptor 139 0.0023 0.0082 0.0255
Toxoplasma gondii hypothetical protein 0.008 0.0437 0.116
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0053 0.0265 0.5559
Echinococcus multilocularis steroid dehydrogenase 0.0016 0.0035 0.0026
Brugia malayi nuclear receptor RXR 0.0083 0.0458 0.0675
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0082 0.0073
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0023 0.0082 0.0124
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0023 0.0082 0.0286
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0265 0.0524
Brugia malayi follicle stimulating hormone receptor 0.0023 0.0082 0.0107
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.0075 0.0228
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.006 0.0135
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0082 0.0255
Loa Loa (eye worm) hypothetical protein 0.0103 0.058 0.0877
Treponema pallidum DNA ligase (lig) 0.002 0.006 0.0208
Brugia malayi neuropeptide F receptor 0.0023 0.0082 0.0107
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0082 0.0092
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0023 0.0082 0.0073
Schistosoma mansoni topbp1 0.002 0.006 0.0208
Loa Loa (eye worm) hypothetical protein 0.1071 0.6614 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.004 0.001
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0437 0.0645
Echinococcus granulosus transient receptor potential cation channel 0.0172 0.1009 0.3482
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.004 0.001
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0023 0.0082 0.0073
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0113 0.0643 0.0972
Echinococcus granulosus uncharacterized sodium dependent transporter 0.008 0.0437 0.1491
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0227 0.0786
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0113 0.0643 0.0956
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0082 0.0073
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0014 0.0028 0.0019
Loa Loa (eye worm) hypothetical protein 0.008 0.0437 0.0661
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0082 0.0286
Echinococcus granulosus sex peptide receptor 0.0023 0.0082 0.0255
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.003 0.0123 0.0428
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0016 0.0035 0.0092
Brugia malayi tailless protein 0.003 0.0123 0.0169
Entamoeba histolytica hypothetical protein 0.0072 0.0384 0.1019
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.0075 0.0228
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.008 0.0437 0.1518
Onchocerca volvulus 0.0022 0.0077 0.0099
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0615 0.3771 0.5693
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0035 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0113 0.0643 0.0972
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0113 0.0643 0.2207
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0023 0.0082 0.0107
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.003 0.0123 0.0428
Echinococcus multilocularis dro:myosuppressin receptor 0.0023 0.0082 0.0073
Onchocerca volvulus 0.0023 0.0082 0.0107
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0016 0.0035 0.0026
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0097 0.0219
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0023 0.0082 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0477 0.1183
Entamoeba histolytica hypothetical protein 0.002 0.006 0.0159
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0091
Brugia malayi Nuclear hormone receptor E75 0.003 0.0123 0.0169
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.0123 0.0398
Trichomonas vaginalis fk506-binding protein, putative 0.0053 0.0265 0.0617
Schistosoma mansoni DNA helicase recq1 0.002 0.006 0.0208
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0082 0.0124
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0086 0.0477 0.1265
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0082 0.0073
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0113 0.0643 0.2232
Echinococcus multilocularis G-protein coupled receptor, putative 0.0023 0.0082 0.0073
Loa Loa (eye worm) hypothetical protein 0.003 0.0123 0.0187
Mycobacterium ulcerans hypothetical protein 0.0615 0.3771 0.7252
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0082 0.0124
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Loa Loa (eye worm) oxidoreductase 0.0016 0.0035 0.0053
Loa Loa (eye worm) TYRA-2 protein 0.0023 0.0082 0.0124
Entamoeba histolytica hypothetical protein 0.0086 0.0477 0.1265
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.008 0.0437 0.0429
Onchocerca volvulus 0.0023 0.0082 0.0107
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.006 0.0067
Echinococcus multilocularis neuropeptide FF receptor 2 0.0023 0.0082 0.0073
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.006 0.0159
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0014 0.0028 0.0019
Onchocerca volvulus Protein ultraspiracle homolog 0.0113 0.0643 0.0956
Schistosoma mansoni topbp1 0.002 0.006 0.0208
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0053
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Echinococcus granulosus bloom syndrome protein 0.002 0.006 0.0176
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0167 0.0978 0.3393
Schistosoma mansoni amine GPCR 0.0023 0.0082 0.0286
Echinococcus granulosus g-protein coupled receptor 0.0023 0.0082 0.0255
Echinococcus multilocularis GPCR, family 2 0.0047 0.0228 0.0219
Brugia malayi hypothetical protein 0.002 0.006 0.0073
Brugia malayi ERG2 and Sigma1 receptor like protein 0.072 0.4429 0.669
Schistosoma mansoni hypothetical protein 0.0011 0.0009 0.0032
Echinococcus granulosus serotonin transporter 0.0472 0.2881 1
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.006 0.0567
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0023 0.0082 0.0107
Echinococcus granulosus serotonin receptor 0.0023 0.0082 0.0255
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0113 0.0643 0.0956
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0082 0.0073
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0016 0.0035 0.0079
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0035 0.0121
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.0075 0.0228
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0016 0.0035 0.0121
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0053 0.0265 0.092
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0082 0.0073
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.006 0.0067
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Schistosoma mansoni immunophilin 0.0045 0.022 0.0764
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0016 0.0035 0.0079
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0035
Onchocerca volvulus 0.0023 0.0082 0.0107
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.003 0.0123 0.0169
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0016 0.0035 0.0079
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0016 0.0035 0.0092
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0053
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0082 0.0255
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0035 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.002 0.006 0.0067
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0035 0.0121
Brugia malayi Dopamine receptor 0.0023 0.0082 0.0107
Brugia malayi Dehydrogenases, short chain protein 2 0.0016 0.0035 0.0035
Trichomonas vaginalis immunophilin, putative 0.0053 0.0265 0.0617
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Echinococcus multilocularis fk506 binding protein 0.0053 0.0265 0.0256
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0035 0.0079
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0023 0.0082 0.0286
Schistosoma mansoni neuropeptide receptor 0.0023 0.0082 0.0286
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0082 0.0124
Trypanosoma cruzi short chain dehydrogenase, putative 0.0016 0.0035 0.0079
Loa Loa (eye worm) hypothetical protein 0.0615 0.3771 0.5701
Loa Loa (eye worm) hypothetical protein 0.0086 0.0477 0.0721
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0565 0.0838
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0227 0.0325
Brugia malayi Niemann-Pick C1 protein precursor 0.0196 0.1159 0.1738
Brugia malayi steroid hormone receptor 0.0113 0.0643 0.0956
Schistosoma mansoni amine GPCR 0.0023 0.0082 0.0286
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.008 0.0437 0.0429
Brugia malayi dehydrogenases, short chain protein 9 0.0016 0.0035 0.0035
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0384 0.1333
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0113 0.0643 0.0635
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Schistosoma mansoni hypothetical protein 0.0014 0.0028 0.0098
Schistosoma mansoni hypothetical protein 0.0072 0.0384 0.1333
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.006 0.0067
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0023 0.0082 0.0107
Schistosoma mansoni hypothetical protein 0.0047 0.0228 0.0791
Onchocerca volvulus 0.0023 0.0082 0.0107
Echinococcus multilocularis retinol dehydrogenase 11 0.0016 0.0035 0.0026
Echinococcus multilocularis Niemann Pick C1 protein 0.0196 0.1159 0.1151
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0615 0.3771 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0023 0.0082 0.0124
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0083 0.0458 0.0692
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0082 0.0092
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0472 0.2881 1
Schistosoma mansoni DNA helicase recq5 0.002 0.006 0.0208
Echinococcus granulosus hypothetical protein 0.0016 0.0035 0.0089
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0045 0.022 0.0211
Loa Loa (eye worm) hypothetical protein 0.008 0.0437 0.0661
Echinococcus granulosus replication factor c subunit 1 0.002 0.006 0.0177
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0053
Schistosoma mansoni biogenic amine receptor 0.0023 0.0082 0.0286
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0086 0.0477 0.1265
Echinococcus multilocularis retinol dehydrogenase 13 0.0016 0.0035 0.0026
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0016 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Echinococcus granulosus oxidoreductase 0.0016 0.0035 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0113 0.0643 0.0956
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.006 0.0208
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0082 0.0092
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0016 0.0035 0.0089
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0016 0.0035 0.0035
Brugia malayi hypothetical protein 0.0016 0.0035 0.0035
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0082 0.0073
Schistosoma mansoni RAR-like nuclear receptor 0.0113 0.0643 0.2232
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Schistosoma mansoni glutamate receptor kainate 0.0014 0.0028 0.0098
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.006 0.0159
Entamoeba histolytica short chain dehydrogenase family protein 0.0016 0.0035 0.0092
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.0069
Onchocerca volvulus 0.008 0.0437 0.0645
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0092
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0082 0.0092
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Onchocerca volvulus 0.0016 0.0035 0.0035
Echinococcus granulosus geminin 0.0172 0.1008 0.3476
Schistosoma mansoni hypothetical protein 0.0081 0.0443 0.1538
Loa Loa (eye worm) nuclear receptor nhr-7B 0.003 0.0123 0.0187
Toxoplasma gondii hypothetical protein 0.008 0.0437 0.116
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.006 0.0135
Echinococcus granulosus allatostatin A receptor 0.0023 0.0082 0.0255
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0016 0.0035 0.0026
Schistosoma mansoni neuropeptide receptor 0.0023 0.0082 0.0286
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.0855 0.1277
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.008 0.0437 0.116
Echinococcus granulosus 7TM GPCR rhodopsin 0.0023 0.0082 0.0255
Schistosoma mansoni carbonyl reductase 0.0016 0.0035 0.0121
Brugia malayi photoreceptor-specific nuclear receptor 0.0113 0.0643 0.0956
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0035
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.006 0.0067
Echinococcus multilocularis synaptic glycoprotein sc2 0.0086 0.0477 0.0468
Brugia malayi hypothetical protein 0.008 0.0437 0.0645
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0082 0.0073
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0016 0.0035 0.0079
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0615 0.3771 0.8503
Loa Loa (eye worm) serotonin transporter b 0.0472 0.2881 0.4356
Loa Loa (eye worm) hypothetical protein 0.0083 0.0458 0.0692
Leishmania major peptidylprolyl isomerase-like protein 0.0053 0.0265 0.0524
Echinococcus multilocularis serotonin receptor 0.0379 0.2301 0.2294
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0082 0.0073
Echinococcus multilocularis ankyrin repeat protein 0.0167 0.0978 0.0969
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0082 0.0286
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0265 0.0599
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0053 0.0265 0.0384
Loa Loa (eye worm) hypothetical protein 0.003 0.0123 0.0187
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0113 0.0643 0.0956
Toxoplasma gondii ATPase, AAA family protein 0.002 0.006 0.0159
Schistosoma mansoni adenoreceptor 0.0023 0.0082 0.0286
Schistosoma mansoni glutamate receptor kainate 0.0014 0.0028 0.0098
Onchocerca volvulus 0.0023 0.0082 0.0107
Brugia malayi Glutamate receptor 1 precursor 0.0014 0.0028 0.0025
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0035
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0016 0.0035 0.0121
Echinococcus granulosus retinol dehydrogenase 11 0.0016 0.0035 0.0089
Brugia malayi DKFZp564C0469 protein 0.002 0.006 0.0073
Brugia malayi AKH receptor 0.0023 0.0082 0.0107
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0016 0.0035 0.0035
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0086 0.0477 0.1265
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0035
Onchocerca volvulus Bile acid receptor homolog 0.1071 0.6614 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.0069
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0083 0.0458 0.1588
Echinococcus granulosus fmrfamide receptor 0.0023 0.0082 0.0255
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0086 0.0477 1
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0035 0.0121
Onchocerca volvulus 0.0016 0.0035 0.0035
Loa Loa (eye worm) oxidoreductase 0.0016 0.0035 0.0053
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0082 0.0073
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.002 0.006 0.5299
Echinococcus granulosus dro:myosuppressin receptor 0.0023 0.0082 0.0255
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0082 0.0073
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0035
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0023 0.0082 0.0107
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0053 0.0265 0.0384
Loa Loa (eye worm) DR-78 0.003 0.0123 0.0187
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0228 0.0762
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.006 0.0051
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0462 0.1577
Schistosoma mansoni biogenic amine receptor 0.0023 0.0082 0.0286
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0082 0.0286
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.008 0.0437 0.0661
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0113 0.0643 0.0956
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0113 0.0643 0.0635
Loa Loa (eye worm) steroid hormone receptor 0.0113 0.0643 0.0972
Loa Loa (eye worm) hypothetical protein 0.0472 0.2881 0.4356
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0083 0.0458 0.0449
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0082 0.0286
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0086 0.0477 0.1183
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0082 0.0218
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0082 0.0073
Schistosoma mansoni histamine h1 receptor 0.0023 0.0082 0.0286
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0082 0.0286
Brugia malayi Nuclear hormone receptor-like 1 0.0083 0.0458 0.0675
Brugia malayi RE15519p 0.0023 0.0082 0.0107
Echinococcus granulosus glutamate NMDA receptor subunit 0.0014 0.0028 0.0066
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Onchocerca volvulus 0.0023 0.0082 0.0107
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0037 0.0169 0.0261
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0053 0.0265 0.0447
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0046 0.0959
Entamoeba histolytica hypothetical protein 0.0072 0.0384 0.1019
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0384 0.1306
Onchocerca volvulus 0.0023 0.0082 0.0107
Echinococcus granulosus hypothetical protein 0.0023 0.0082 0.0255
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.009
Echinococcus multilocularis transient receptor potential cation channel 0.0172 0.1011 0.1003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0082 0.0286
Brugia malayi G protein-coupled receptor F59B2.13 0.0023 0.0082 0.0107
Echinococcus granulosus sodium and chloride dependent glycine 0.008 0.0437 0.1491
Onchocerca volvulus 0.0086 0.0477 0.0704
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0082 0.0073
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0035
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0082 0.0073
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0014 0.0028 0.0019
Toxoplasma gondii hypothetical protein 0.0012 0.0012 0.0031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Onchocerca volvulus 0.0023 0.0082 0.0107
Schistosoma mansoni thyroid hormone receptor 0.0113 0.0643 0.2232
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.0069
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0023 0.0082 0.0073
Echinococcus granulosus glutamate receptor 2 0.0022 0.0075 0.0228
Onchocerca volvulus 0.0472 0.2881 0.4346
Toxoplasma gondii oxidoreductase, putative 0.0016 0.0035 0.0092
Schistosoma mansoni hypothetical protein 0.0047 0.0228 0.0791
Schistosoma mansoni neuropeptide f receptor 76f 0.0023 0.0082 0.0286
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0615 0.3771 1
Brugia malayi neuropeptide F receptor 0.0023 0.0082 0.0107
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0035 0.0121
Echinococcus multilocularis G protein coupled receptor 139 0.0023 0.0082 0.0073
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0265 0.0599
Echinococcus granulosus neuropeptide receptor A26 0.0023 0.0082 0.0255
Echinococcus multilocularis neuropeptide receptor A26 0.0023 0.0082 0.0073
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0016 0.0035 0.0092
Loa Loa (eye worm) hypothetical protein 0.003 0.0123 0.0187
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0016 0.0035 0.0092
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0091
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Echinococcus multilocularis transient receptor potential cation channel 0.0016 0.0035 0.0026
Schistosoma mansoni nuclear receptor 0.003 0.0123 0.0428
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0113 0.0643 0.2207
Loa Loa (eye worm) hypothetical protein 0.0379 0.2301 0.3479
Plasmodium vivax hypothetical protein, conserved 0.008 0.0437 0.9174
Schistosoma mansoni glutamate receptor AMPA 0.0014 0.0028 0.0098
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.006 0.1034
Echinococcus multilocularis glutamate receptor 2 0.0022 0.0075 0.0065
Loa Loa (eye worm) hypothetical protein 0.0083 0.0458 0.0692
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.008 0.0437 0.116
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0086 0.0477 0.1183
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0053 0.0265 0.0617
Brugia malayi Nuclear hormone receptor-like 1 0.0113 0.0643 0.0956
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0082 0.0286
Echinococcus granulosus ecdysone induced protein 78C 0.0113 0.0643 0.2207
Echinococcus multilocularis somatostatin receptor 0.0023 0.0082 0.0073
Brugia malayi Synaptic glycoprotein SC2 0.0086 0.0477 0.0704
Loa Loa (eye worm) hypothetical protein 0.003 0.0123 0.0187
Loa Loa (eye worm) hypothetical protein 0.0084 0.0462 0.0699
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0053 0.0265 0.521
Loa Loa (eye worm) oxidoreductase 0.0016 0.0035 0.0053
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0035 0.0121
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0053 0.0265 0.5446
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0082 0.0255
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0082 0.0092
Loa Loa (eye worm) hypothetical protein 0.003 0.0123 0.0187
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Onchocerca volvulus 0.008 0.0437 0.0645
Plasmodium vivax patched family protein, putative 0.0012 0.0012 0.0249
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0035 0.0121
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0016 0.0035 0.0079
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0023 0.0082 0.0073
Onchocerca volvulus 0.0016 0.0035 0.0035
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0086 0.0477 0.1265
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0615 0.3771 1
Schistosoma mansoni hypothetical protein 0.0023 0.0082 0.0286
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.008 0.0437 0.0661
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0016 0.0035 0.0079
Giardia lamblia Synaptic glycoprotein SC2 0.0086 0.0477 1
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0014 0.0028 0.0066
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0437 0.0645
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0016 0.0035 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0113 0.0643 0.0972
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.008 0.0437 0.0645
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0227 0.0757
Echinococcus multilocularis sodium and chloride dependent glycine 0.008 0.0437 0.0429
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0016 0.0035 0.0089
Echinococcus granulosus nuclear receptor nhr 48 0.003 0.0123 0.0398
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0083 0.0458 0.0692
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0082 0.0073
Loa Loa (eye worm) FKBP5 protein 0.0053 0.0265 0.0401
Schistosoma mansoni hypothetical protein 0.0172 0.1008 0.3497
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0113 0.0643 0.0635
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0023 0.0082 0.0073
Schistosoma mansoni neuropeptide receptor 0.0023 0.0082 0.0286
Brugia malayi conserved hypotetical protein 0.003 0.0123 0.0169
Onchocerca volvulus 0.0023 0.0082 0.0107
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0082 0.0255
Schistosoma mansoni hypothetical protein 0.0081 0.0443 0.1538
Brugia malayi hypothetical protein 0.0026 0.0097 0.0129
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0082 0.0073
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0228 0.0345
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0462 0.1144
Echinococcus multilocularis FTZ F1 alpha 0.0113 0.0643 0.0635
Echinococcus multilocularis carbonyl reductase 1 0.0016 0.0035 0.0026
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0016 0.0035 0.0079
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0615 0.3771 1
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0016 0.0035 0.0121
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0082 0.0255
Schistosoma mansoni immunophilin 0.0053 0.0265 0.092
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0113 0.0643 0.0956
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.008 0.0437 0.1518
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0046 0.0021
Echinococcus multilocularis ecdysone induced protein 78C 0.0113 0.0643 0.0635
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0082 1
Onchocerca volvulus 0.003 0.0123 0.0169
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.006 0.0159
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Toxoplasma gondii patched family protein 0.0012 0.0012 0.0031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0227 0.0757
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0082 0.0286
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0082 0.0255
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0265 0.0891
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0053
Echinococcus multilocularis nibrin 0.002 0.006 0.0051
Onchocerca volvulus 0.0023 0.0082 0.0107
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.008 0.0437 0.1491
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0035 0.0729
Brugia malayi hydrolase, alpha/beta fold family protein 0.0515 0.315 0.4753
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0037 0.0169 0.0588
Schistosoma mansoni glutamate receptor AMPA 0.0014 0.0028 0.0098
Echinococcus granulosus carbonyl reductase 1 0.0016 0.0035 0.0089
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0265 0.0256
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.006 0.0067
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.003 0.0123 0.0398
Loa Loa (eye worm) hypothetical protein 0.0045 0.022 0.0333
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0082 0.0286
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0014 0.0028 0.0066
Echinococcus multilocularis orexin receptor type 2 0.0023 0.0082 0.0073
Brugia malayi Nuclear hormone receptor E75 0.003 0.0123 0.0169
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0082 0.0092
Mycobacterium ulcerans short chain dehydrogenase 0.0842 0.5187 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0228 0.0219
Onchocerca volvulus 0.0016 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0472 0.2881 0.4356
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.006 0.0135
Treponema pallidum sodium- and chloride- dependent transporter 0.0472 0.2881 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0053
Onchocerca volvulus 0.0016 0.0035 0.0035
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.0123 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0113 0.0643 0.0956
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0113 0.0643 0.2232
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0023 0.0082 0.0286
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0086 0.0477 0.1628
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0082 0.0286
Loa Loa (eye worm) dehydrogenase 0.0016 0.0035 0.0053
Onchocerca volvulus 0.0016 0.0035 0.0035
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.0123 0.0169
Echinococcus multilocularis sex peptide receptor 0.0023 0.0082 0.0073
Trypanosoma cruzi C-8 sterol isomerase, putative 0.072 0.4429 1
Schistosoma mansoni hypothetical protein 0.0081 0.0443 0.1538
Loa Loa (eye worm) hypothetical protein 0.003 0.0123 0.0187
Loa Loa (eye worm) RecQ helicase 0.002 0.006 0.009
Loa Loa (eye worm) glutamate receptor 1 0.0014 0.0028 0.0043
Onchocerca volvulus 0.0023 0.0082 0.0107
Schistosoma mansoni nuclear hormone receptor 0.003 0.0123 0.0428
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Brugia malayi hypothetical protein 0.0016 0.0041 0.0043
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0035 0.0121
Loa Loa (eye worm) hypothetical protein 0.0113 0.0643 0.0972
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.006 0.0057
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0023 0.0082 0.0124
Brugia malayi nuclear receptor NHR-88 0.0113 0.0643 0.0956
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.006 0.0073
Loa Loa (eye worm) hydrolase 0.1038 0.6408 0.9688
Brugia malayi Dopamine receptor protein 2 0.0023 0.0082 0.0107
Brugia malayi nuclear receptor NHR-88 0.003 0.0123 0.0169
Schistosoma mansoni myosin xvIII 0.0023 0.0082 0.0286
Schistosoma mansoni amine GPCR 0.0023 0.0082 0.0286
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.008 0.0437 0.1518
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0082 0.0073
Plasmodium vivax steroid dehydrogenase, putative 0.0016 0.0035 0.0729
Loa Loa (eye worm) hypothetical protein 0.0083 0.0458 0.0692
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0082 0.0073
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0053 0.0265 0.092
Brugia malayi Tachykinin-like peptides receptor 99D 0.0023 0.0082 0.0107
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0037 0.0169 0.3159
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0091
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0091
Echinococcus granulosus biogenic amine 5HT receptor 0.0379 0.2301 0.7979
Loa Loa (eye worm) hypothetical protein 0.0196 0.1159 0.1753
Brugia malayi hypothetical protein 0.0072 0.0384 0.0564
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.006 0.0073
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.008 0.0437 0.1491
Echinococcus granulosus neuropeptide FF receptor 2 0.0023 0.0082 0.0255
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0016 0.0035 0.0092
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0035
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0082 0.0255
Echinococcus multilocularis Niemann Pick C1 protein 0.028 0.1684 0.1676
Schistosoma mansoni carbonyl reductase 0.0016 0.0035 0.0121
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0016 0.0035 0.0026
Loa Loa (eye worm) oxidoreductase 0.0016 0.0035 0.0053
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.008 0.0437 0.0661
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Loa Loa (eye worm) hypothetical protein 0.0086 0.0477 0.0721
Loa Loa (eye worm) oxidoreductase 0.0016 0.0035 0.0053
Schistosoma mansoni glutamate receptor NMDA 0.0022 0.0075 0.0259
Chlamydia trachomatis DNA ligase 0.002 0.006 0.0363
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0082 0.0073
Onchocerca volvulus Neuropeptide F receptor homolog 0.0023 0.0082 0.0107
Echinococcus multilocularis thyroid hormone receptor alpha 0.0113 0.0643 0.0635
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0082 0.0073
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.006 0.0067
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0016 0.0035 0.0092
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.002 0.006 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0565 0.0854
Plasmodium falciparum amino acid transporter, putative 0.008 0.0437 0.9153
Entamoeba histolytica short chain dehydrogenase family protein 0.0016 0.0035 0.0092
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0113 0.0643 0.2232
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0037 0.0169 0.0261
Schistosoma mansoni hypothetical protein 0.0023 0.0082 0.0286
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0082 0.0073
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.008 0.0437 1
Echinococcus granulosus sodium and chloride dependent glycine 0.008 0.0437 0.1491
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0014 0.0028 0.0019
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0035 0.0121
Echinococcus multilocularis glutamate receptor 2 0.0014 0.0028 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0113 0.0643 0.2207
Brugia malayi Retinol dehydrogenase 12 0.0016 0.0035 0.0035
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0023 0.0082 0.0073
Onchocerca volvulus 0.0016 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.0855 0.1277
Schistosoma mansoni immunophilin 0.0053 0.0265 0.092
Schistosoma mansoni glutamate receptor kainate 0.0014 0.0028 0.0098
Schistosoma mansoni retinoic acid receptor RXR 0.0113 0.0643 0.2232
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0035 0.0121
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0265 0.0599
Brugia malayi hypothetical protein 0.0023 0.0082 0.0107
Loa Loa (eye worm) hypothetical protein 0.0113 0.0643 0.0972
Loa Loa (eye worm) hypothetical protein 0.003 0.0123 0.0187
Echinococcus multilocularis expressed conserved protein 0.0184 0.1085 0.1077
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0035
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0082 0.0255
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0023 0.0082 0.0124
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Toxoplasma gondii oxidoreductase, putative 0.0016 0.0035 0.0092
Brugia malayi ecdysone receptor 0.003 0.0123 0.0169
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0082 0.0286
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0091
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.008 0.0437 0.1518
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0016 0.0035 0.0079
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0053 0.0265 0.0703
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0016 0.0035 0.0026
Echinococcus granulosus hypothetical protein 0.0016 0.0035 0.0089
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Schistosoma mansoni hypothetical protein 0.0023 0.0082 0.0286
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.0123 0.0169
Brugia malayi dehydrogenases, short chain protein 2 0.0016 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Echinococcus multilocularis nmda type glutamate receptor 0.0052 0.026 0.0251
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.008 0.0437 0.1518
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0053
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0083 0.0458 0.1561
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0437 0.0645
Echinococcus granulosus carbonyl reductase 1 0.0016 0.0035 0.0089
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.006 0.1032
Brugia malayi Bloom's syndrome protein homolog 0.002 0.006 0.0073
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0053
Loa Loa (eye worm) hypothetical protein 0.008 0.0437 0.0661
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0368 0.2233 0.3376
Echinococcus granulosus neuropeptide receptor 0.0023 0.0082 0.0255
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0053
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0615 0.3771 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0082 0.0255
Echinococcus multilocularis conserved hypothetical protein 0.0016 0.0035 0.0026
Echinococcus multilocularis g-protein coupled receptor 0.0023 0.0082 0.0073
Brugia malayi Melatonin receptor type 1A 0.0023 0.0082 0.0107
Mycobacterium ulcerans hypothetical protein 0.0023 0.0082 0.0092
Schistosoma mansoni nuclear hormone receptor 0.003 0.0123 0.0428
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0053
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0035 0.0121
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.008 0.0437 0.116
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0035 0.0121
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.0075 0.0065
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0035 0.0121
Schistosoma mansoni sodium-dependent amino acid transporter 0.008 0.0437 0.1518
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0227 0.0343
Brugia malayi sulfakinin receptor protein 0.0023 0.0082 0.0107
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0016 0.0035 0.0079
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.002 0.006 0.0049
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0086 0.0477 0.0468
Loa Loa (eye worm) hypothetical protein 0.0113 0.0643 0.0972
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0023 0.0082 0.0286
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.0075 0.0065
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.003 0.0123 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0113 0.0643 0.0956
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Echinococcus multilocularis protein dispatched 1 0.0096 0.0536 0.0527
Schistosoma mansoni opsin-like receptor 0.0023 0.0082 0.0286
Schistosoma mansoni glutamate receptor NMDA 0.0014 0.0028 0.0098
Trypanosoma cruzi short chain dehydrogenase, putative 0.0016 0.0035 0.0079
Loa Loa (eye worm) hypothetical protein 0.003 0.0123 0.0187
Echinococcus multilocularis serotonin transporter 0.0472 0.2881 0.2875
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.004 0.001
Echinococcus granulosus g protein coupled receptor 0.0023 0.0082 0.0255
Brugia malayi nuclear receptor RXR 0.003 0.0123 0.0169
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0472 0.2881 0.4346
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Brugia malayi hypothetical protein 0.0083 0.0458 0.0675
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.008 0.0437 0.1518
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.008 0.0437 0.0429
Echinococcus granulosus carbonyl reductase 1 0.0016 0.0035 0.0089
Echinococcus granulosus glutamate receptor subunit protein glur 0.0014 0.0028 0.0066
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0023 0.0082 0.0107
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0016 0.0035 0.0035
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0053 0.0265 0.0891
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0035 0.0121
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0016 0.0035 0.0089
Leishmania major fk506-binding protein 1-like protein 0.0053 0.0265 0.0524
Schistosoma mansoni sodium/chloride dependent transporter 0.008 0.0437 0.1518
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0086 0.0477 0.1655
Brugia malayi hypothetical protein 0.0083 0.0458 0.0675
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0035
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.0075 0.0065
Brugia malayi nuclear hormone receptor family member odr-7 0.003 0.0123 0.0169
Loa Loa (eye worm) oxidoreductase 0.0016 0.0035 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.002 0.006 0.0067
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0023 0.0082 0.0255
Brugia malayi nuclear hormone receptor 0.0113 0.0643 0.0956
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.006 0.0135
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0035 0.0121
Brugia malayi hypothetical protein 0.0023 0.0082 0.0107
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0113 0.0643 0.2232
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0113 0.0643 0.0956
Brugia malayi topoisomerase 0.002 0.006 0.0073
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0615 0.3771 0.8514
Echinococcus granulosus FTZ F1 alpha 0.0113 0.0643 0.2207
Onchocerca volvulus 0.0016 0.0035 0.0035
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0097 0.0141
Schistosoma mansoni biogenic amine receptor 0.0023 0.0082 0.0286
Onchocerca volvulus 0.0023 0.0082 0.0107
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0091
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.006 0.0073
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.0069
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0035
Entamoeba histolytica hypothetical protein, conserved 0.0016 0.0035 0.0092
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0462 0.0453
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0082 0.0255
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0082 0.0073
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0016 0.0035 0.0092
Schistosoma mansoni coup transcription factor 0.0113 0.0643 0.2232
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0199 0.1178 0.4089
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0097 0.2033
Brugia malayi G-protein coupled receptor 0.0023 0.0082 0.0107
Loa Loa (eye worm) nuclear hormone receptor 0.003 0.0123 0.0187
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0113 0.0643 0.0972
Loa Loa (eye worm) hypothetical protein 0.0026 0.0097 0.0147
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0082 0.0107
Schistosoma mansoni sodium/chloride dependent transporter 0.008 0.0437 0.1518
Trichomonas vaginalis conserved hypothetical protein 0.002 0.006 0.0067
Loa Loa (eye worm) hypothetical protein 0.003 0.0123 0.0187
Schistosoma mansoni steroid hormone receptor ad4bp 0.0113 0.0643 0.2232
Brugia malayi CHE-14 protein 0.0084 0.0462 0.0682
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0228 0.0762
Schistosoma mansoni hypothetical protein 0.0047 0.0228 0.0791
Brugia malayi hypothetical protein 0.0023 0.0082 0.0107
Entamoeba histolytica hypothetical protein 0.0072 0.0384 0.1019
Trichomonas vaginalis conserved hypothetical protein 0.002 0.006 0.0067
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0082 0.0286
Loa Loa (eye worm) patched family protein 0.0012 0.0012 0.0018
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0082 0.0255
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0113 0.0643 0.0956
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0086 0.0477 0.1183
Onchocerca volvulus 0.0113 0.0643 0.0956
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0082 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0113 0.0643 0.0956
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0035 0.0121
Giardia lamblia Replication factor C, subunit 1 0.002 0.006 0.0569
Echinococcus multilocularis retinol dehydrogenase 11 0.0016 0.0035 0.0026
Brugia malayi Steroid receptor seven-up type 2 0.0113 0.0643 0.0956
Brugia malayi nuclear hormone receptor family member nhr-6 0.003 0.0123 0.0169
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Entamoeba histolytica hypothetical protein 0.0016 0.0035 0.0092
Loa Loa (eye worm) hypothetical protein 0.0113 0.0643 0.0972
Echinococcus granulosus thyroid hormone receptor alpha 0.003 0.0123 0.0398
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Brugia malayi Dopamine receptor protein 1 0.0023 0.0082 0.0107
Loa Loa (eye worm) hypothetical protein 0.0147 0.0855 0.1293
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0086 0.0477 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.006 0.0057
Loa Loa (eye worm) hypothetical protein 0.003 0.0123 0.0187
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0053
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0086 0.0477 0.1077
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0082 0.0092
Onchocerca volvulus 0.0023 0.0082 0.0107
Echinococcus granulosus neuropeptide receptor 0.0023 0.0082 0.0255
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0097 0.0219
Echinococcus granulosus g protein coupled receptor 0.0023 0.0082 0.0255
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0016 0.0035 0.0035
Schistosoma mansoni amine GPCR 0.0023 0.0082 0.0286
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0045 0.022 0.0734
Schistosoma mansoni hypothetical protein 0.0101 0.0565 0.1961
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0113 0.0643 0.0972
Echinococcus granulosus alpha 1A adrenergic receptor 0.0023 0.0082 0.0255
Loa Loa (eye worm) hypothetical protein 0.003 0.0123 0.0187
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0083 0.0458 0.1588
Brugia malayi hypothetical protein 0.003 0.0123 0.0169
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.0123 0.0114
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0082 0.0073
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0082 0.0255
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0082 0.0092
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.006 0.0135
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0016 0.0035 0.0079
Loa Loa (eye worm) glutamate receptor 2 0.0014 0.0028 0.0043
Loa Loa (eye worm) nuclear receptor NHR-67 0.003 0.0123 0.0187
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0462 0.0699
Schistosoma mansoni growth hormone secretagogue receptor 0.0023 0.0082 0.0286
Brugia malayi Dehydrogenases, short chain protein 30 0.0016 0.0035 0.0035
Onchocerca volvulus 0.0023 0.0082 0.0107
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0092
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0023 0.0082 0.0255
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0082 0.0255
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0082 0.0255
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0023 0.0082 0.0286
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0053 0.0265 0.521
Brugia malayi putative neuropeptide receptor NPR1 0.0023 0.0082 0.0107
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0082 0.0255
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Loa Loa (eye worm) hypothetical protein 0.008 0.0437 0.0661
Echinococcus granulosus nmda type glutamate receptor 0.0052 0.026 0.0873
Schistosoma mansoni DNA ligase IV 0.002 0.006 0.0208
Schistosoma mansoni nuclear hormone receptor 0.0113 0.0643 0.2232
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0082 0.0107
Onchocerca volvulus 0.0023 0.0082 0.0107
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0082 0.0108
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0082 0.0286
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0023 0.0082 0.0073
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0046 0.0729
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.008 0.0437 0.1518
Loa Loa (eye worm) hypothetical protein 0.0047 0.0228 0.0345
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Echinococcus granulosus Niemann Pick C1 protein 0.028 0.1684 0.583
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0035 0.0121
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0016 0.0035 0.0092
Echinococcus granulosus neuropeptide s receptor 0.0023 0.0082 0.0255
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.0069
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0092
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0053 0.0265 0.0617
Toxoplasma gondii patched family protein 0.0012 0.0012 0.0031
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0092
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0123 0.0114
Schistosoma mansoni biogenic amine (5HT) receptor 0.0379 0.2301 0.7985
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0035 0.0121
Onchocerca volvulus 0.0016 0.0035 0.0035
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0035
Onchocerca volvulus 0.0016 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.008 0.0437 0.0661
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0082 0.0286
Loa Loa (eye worm) hypothetical protein 0.0083 0.0458 0.0692
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Toxoplasma gondii patched family protein 0.0012 0.0012 0.0031
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0265 0.0524
Schistosoma mansoni neuropeptide receptor 0.0023 0.0082 0.0286
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0172 0.1008 0.3497
Schistosoma mansoni alpha-1 adrenergic receptor 0.0023 0.0082 0.0286
Schistosoma mansoni patched 1 0.0084 0.0462 0.1603
Entamoeba histolytica hypothetical protein, conserved 0.0016 0.0035 0.0092
Leishmania major hypothetical protein, conserved 0.0026 0.0097 0.0141
Brugia malayi G protein-coupled receptor 0.0023 0.0082 0.0107
Brugia malayi Serotonin receptor 0.0023 0.0082 0.0107
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Echinococcus multilocularis nuclear receptor nhr 48 0.003 0.0123 0.0114
Echinococcus granulosus ankyrin repeat protein 0.0167 0.0978 0.3372
Echinococcus multilocularis NMDA receptor 0.0014 0.0028 0.0019
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0035
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0023 0.0082 0.0286
Onchocerca volvulus 0.008 0.0437 0.0645
Loa Loa (eye worm) patched family protein 0.0012 0.0012 0.0018
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.006 0.0057
Schistosoma mansoni retinal dehydrogenase 0.0016 0.0035 0.0121
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0035 0.0121
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0016 0.0035 0.0079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0082 0.0073
Echinococcus multilocularis sodium and chloride dependent glycine 0.008 0.0437 0.0429
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0023 0.0082 0.0286
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Brugia malayi hypothetical protein 0.0016 0.0035 0.0035
Echinococcus granulosus somatostatin receptor 0.0023 0.0082 0.0255
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0082 0.0286
Brugia malayi oxidoreductase 0.0016 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.0855 0.1293
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0046 0.0021
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0082 0.0107
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0113 0.0643 0.0635
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0016 0.0035 0.0079
Schistosoma mansoni hypothetical protein 0.0081 0.0443 0.1538
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.006 0.1032
Schistosoma mansoni nuclear receptor nhr-48 0.003 0.0123 0.0428
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.004 0.001
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0053 0.0265 0.0703
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0035 0.0121
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0052 0.026 0.0251
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.006 0.0051
Loa Loa (eye worm) hypothetical protein 0.0113 0.0643 0.0972
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.006 0.0073
Echinococcus granulosus uncharacterized sodium dependent transporter 0.008 0.0437 0.1491
Echinococcus multilocularis replication factor c subunit 1 0.002 0.006 0.0051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0227 0.0786
Loa Loa (eye worm) hypothetical protein 0.0113 0.0643 0.0972
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0082 0.0124
Echinococcus granulosus synaptic glycoprotein sc2 0.0086 0.0477 0.1628
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0615 0.3771 0.8503
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0023 0.0082 0.0124
Echinococcus granulosus orexin receptor type 2 0.0023 0.0082 0.0255
Loa Loa (eye worm) oxidoreductase 0.0016 0.0035 0.0053
Loa Loa (eye worm) hypothetical protein 0.0113 0.0643 0.0972
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0014 0.0028 0.0066
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0016 0.0035 0.0121
Echinococcus granulosus carbonyl reductase 1 0.0016 0.0035 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0477 0.1183
Loa Loa (eye worm) hypothetical protein 0.072 0.4429 0.6695
Entamoeba histolytica hypothetical protein 0.0072 0.0384 0.1019
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0113 0.0643 0.2207
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0082 0.0218
Loa Loa (eye worm) oxidoreductase 0.0016 0.0035 0.0053
Chlamydia trachomatis glutamine binding protein 0.0037 0.0169 0.3159
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0113 0.0643 0.2207
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.0123 0.0114
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.008 0.0437 0.1518
Echinococcus granulosus peptide allatostatin:somatostatin 0.0023 0.0082 0.0255
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0053 0.0265 0.0401
Brugia malayi nuclear receptor NHR-67 0.003 0.0123 0.0169
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0113 0.0643 0.2207
Echinococcus multilocularis carbonyl reductase 1 0.0016 0.0035 0.0026
Loa Loa (eye worm) solute carrier family 6 member 4 0.0472 0.2881 0.4356
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0082 0.0255
Leishmania major C-8 sterol isomerase-like protein 0.072 0.4429 1
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0035 0.0121
Loa Loa (eye worm) hypothetical protein 0.001 0.000000000050338 0.000000000076105
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0124
Onchocerca volvulus 0.003 0.0123 0.0169
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.006 0.0176
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.006 0.0159
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.003 0.0123 0.0114
Onchocerca volvulus 0.0023 0.0082 0.0107
Loa Loa (eye worm) norepinephrine transporter 0.0472 0.2881 0.4356
Brugia malayi hypothetical protein 0.0023 0.0082 0.0107
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0082 0.0073
Brugia malayi hypothetical protein 0.0023 0.0082 0.0107
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0082 0.0092
Loa Loa (eye worm) patched family protein 0.0012 0.0012 0.0018
Echinococcus granulosus tachykinin peptides receptor 99D 0.0023 0.0082 0.0255
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Entamoeba histolytica recQ family helicase, putative 0.002 0.006 0.0159
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0228 0.0327
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0082 0.0255
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0123 0.0398
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0082 0.0073
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0016 0.0035 0.0493
Loa Loa (eye worm) melatonin receptor type 1A 0.0023 0.0082 0.0124
Loa Loa (eye worm) hypothetical protein 0.003 0.0123 0.0187
Echinococcus multilocularis steroid dehydrogenase 0.0016 0.0035 0.0026
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.006 0.009
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0035 0.0121
Echinococcus multilocularis neuropeptide s receptor 0.0023 0.0082 0.0073
Onchocerca volvulus 0.0023 0.0082 0.0107
Toxoplasma gondii carbonyl reductase 1, putative 0.0016 0.0035 0.0092
Plasmodium falciparum steroid dehydrogenase, putative 0.0016 0.0035 0.0493
Brugia malayi orphan nuclear receptor NR2E1 0.003 0.0123 0.0169
Brugia malayi hypothetical protein 0.0023 0.0082 0.0107
Schistosoma mansoni nuclear receptor 0.003 0.0123 0.0428
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0035 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0082 0.0286
Brugia malayi Nuclear hormone receptor-like 1 0.0083 0.0458 0.0675
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.006 0.1257
Brugia malayi hypothetical protein 0.0023 0.0082 0.0107
Schistosoma mansoni hypothetical protein 0.0047 0.0228 0.0791
Toxoplasma gondii patched family protein 0.0012 0.0012 0.0031
Brugia malayi larval opioid receptor 0.0023 0.0082 0.0107
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0022 0.0075 0.0228
Echinococcus multilocularis oxidoreductase 0.0016 0.0035 0.0026
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0196 0.1159 0.3075
Brugia malayi nuclear hormone receptor 0.003 0.0123 0.0169
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.1038 0.6408 0.9688
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0016 0.0035 0.0035
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0082 0.0255
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0035
Brugia malayi hypothetical protein 0.003 0.0123 0.0169
Echinococcus multilocularis protein patched 0.0084 0.0462 0.0453
Brugia malayi GnHR receptor homolog 0.0023 0.0082 0.0107
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0035 0.0079
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0113 0.0643 0.0956
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0082 1
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0462 0.1577
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Brugia malayi ecdysteroid receptor 0.1071 0.6614 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0082 0.0108
Brugia malayi hypothetical protein 0.002 0.006 0.0073
Plasmodium falciparum polyprenol reductase, putative 0.0086 0.0477 1
Onchocerca volvulus 0.002 0.006 0.0073
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0113 0.0643 0.2232
Echinococcus multilocularis carbonyl reductase 1 0.0016 0.0035 0.0026
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0035 0.0121
Schistosoma mansoni opsin-like receptor 0.0023 0.0082 0.0286
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0016 0.0035 0.0493
Loa Loa (eye worm) patched family protein 0.0012 0.0012 0.0018
Echinococcus multilocularis serotonin receptor 0.0379 0.2301 0.2294
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0113 0.0643 0.0972
Brugia malayi G-protein coupled receptor 0.0023 0.0082 0.0107
Schistosoma mansoni ATP-binding cassette transporter 0.0014 0.0028 0.0098
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0023 0.0082 0.0107
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0228 0.0219
Schistosoma mansoni zinc finger protein 0.003 0.0123 0.0428
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0086 0.0477 0.1183
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0035 0.0035
Echinococcus granulosus 7tm_1 domain containing protein 0.0023 0.0082 0.0255
Trypanosoma brucei C-8 sterol isomerase, putative 0.072 0.4429 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0113 0.0643 0.0956
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.006 0.0176
Mycobacterium tuberculosis Probable oxidoreductase 0.0842 0.5187 1
Echinococcus multilocularis allatostatin A receptor 0.0023 0.0082 0.0073
Loa Loa (eye worm) dehydrogenase 0.0016 0.0035 0.0053
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0023 0.0082 0.0255
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0022 0.0075 0.0065
Schistosoma mansoni carbonyl reductase 0.0016 0.0035 0.0121
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0018
Brugia malayi ORL1-like opioid receptor 0.0023 0.0082 0.0107
Plasmodium vivax amine transporter, putative 0.008 0.0437 0.9174
Plasmodium vivax polyprenol reductase, putative 0.0086 0.0477 1
Brugia malayi hypothetical protein 0.0023 0.0082 0.0107
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.006 0.0067

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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