Detailed information for compound 929667

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 279.376 | Formula: C19H21NO
  • H donors: 1 H acceptors: 0 LogP: 3.12 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC[C@@H]1C[C@@H]2[C@@H](O1)c1ccccc1Cc1c2cccc1
  • InChi: 1S/C19H21NO/c1-20-12-15-11-18-16-8-4-2-6-13(16)10-14-7-3-5-9-17(14)19(18)21-15/h2-9,15,18-20H,10-12H2,1H3/t15-,18-,19-/m0/s1
  • InChiKey: RUKTXHCGSFMYLO-SNRMKQJTSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Starlite/ChEMBL References
Homo sapiens histamine receptor H1 Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Serotonin receptor Get druggable targets OG5_135430 All targets in OG5_135430
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0018 0.0012 0.004
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.0014 0.0047
Echinococcus granulosus allatostatin A receptor 0.0131 0.0225 0.0771
Echinococcus granulosus tachykinin peptides receptor 99D 0.0131 0.0225 0.0771
Mycobacterium leprae Probable oxidoreductase 0.011 0.0186 0.3928
Giardia lamblia Hypothetical protein 0.011 0.0186 0.1895
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0019 0.0014 0.0047
Echinococcus granulosus tm gpcr rhodopsin 0.0131 0.0225 0.0771
Echinococcus granulosus protein tyrosine phosphatase n9 0.0018 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Schistosoma mansoni short chain dehydrogenase 0.011 0.0186 0.0635
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.011 0.0186 0.0066
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0131 0.0225 0.0771
Brugia malayi Delta serrate ligand family protein 0.0508 0.093 0.316
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.011 0.0186 0.0635
Brugia malayi hypothetical protein 0.0131 0.0225 0.0741
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.011 0.0186 0.3928
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.011 0.0186 0.0049
Brugia malayi Calcium binding EGF domain containing protein 0.0508 0.093 0.316
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0131 0.0225 0.0771
Echinococcus granulosus neurogenic locus notch protein 4 0.0508 0.093 0.3182
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0225 0.0771
Echinococcus granulosus fmrfamide receptor 0.0131 0.0225 0.0771
Leishmania major quinonoid dihydropteridine reductase 0.011 0.0186 1
Brugia malayi Serotonin receptor 0.0131 0.0225 0.0741
Brugia malayi Animal haem peroxidase family protein 0.1571 0.2923 1
Onchocerca volvulus 0.011 0.0186 0.0598
Schistosoma mansoni short chain dehydrogenase 0.011 0.0186 0.0635
Echinococcus multilocularis neurogenic locus notch protein 4 0.0508 0.093 0.3182
Brugia malayi Tachykinin-like peptides receptor 99D 0.0131 0.0225 0.0741
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.0607 1
Echinococcus granulosus slit 2 protein 0.0508 0.093 0.3182
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0131 0.0225 0.0771
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0186 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Mycobacterium tuberculosis Probable oxidoreductase 0.011 0.0186 0.0066
Onchocerca volvulus 0.1571 0.2923 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0131 0.0225 0.0771
Schistosoma mansoni notch 0.0508 0.093 0.3182
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0131 0.0225 0.0771
Brugia malayi hypothetical protein 0.011 0.0186 0.0606
Echinococcus multilocularis neuropeptides capa receptor 0.0131 0.0225 0.0771
Echinococcus multilocularis muscleblind protein 1 0.0158 0.0276 0.0943
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0018 0.0012 0.0009
Echinococcus multilocularis GPCR, family 2 0.0206 0.0365 0.1249
Schistosoma mansoni hypothetical protein 0.0206 0.0365 0.1249
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0186 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Echinococcus granulosus alpha 1A adrenergic receptor 0.0131 0.0225 0.0771
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.0014 0.0047
Loa Loa (eye worm) G-protein coupled receptor 0.0131 0.0225 0.0733
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0012 0.004
Onchocerca volvulus 0.0508 0.093 0.3154
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.011 0.0186 0.0066
Trypanosoma cruzi oxidoreductase-like protein, putative 0.011 0.0186 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0225 0.0771
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0012 0.004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0081 0.0277
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0131 0.0225 0.0771
Loa Loa (eye worm) hypothetical protein 0.011 0.0186 0.0598
Schistosoma mansoni steroid dehydrogenase 0.011 0.0186 0.0635
Schistosoma mansoni short-chain dehydrogenase/reductase 0.011 0.0186 0.0635
Echinococcus granulosus cpg binding protein 0.0034 0.0042 0.0145
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0225 0.0771
Echinococcus multilocularis g protein coupled receptor 0.0131 0.0225 0.0771
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0164 0.0286 0.015
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.011 0.0186 0.0049
Schistosoma mansoni neuropeptide receptor 0.0131 0.0225 0.0771
Echinococcus granulosus steroid dehydrogenase 0.011 0.0186 0.0635
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0225 0.0771
Mycobacterium ulcerans short chain dehydrogenase 0.011 0.0186 0.0049
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0026 0.0817
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Schistosoma mansoni biogenic amine (5HT) receptor 0.0131 0.0225 0.0771
Schistosoma mansoni cpg binding protein 0.0034 0.0042 0.0145
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.011 0.0186 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0131 0.0225 0.0733
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0018 0.0012 0.004
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.011 0.0186 0.0049
Brugia malayi Serotonin receptor 0.0687 0.1266 0.4314
Loa Loa (eye worm) hypothetical protein 0.011 0.0186 0.0598
Mycobacterium ulcerans short chain dehydrogenase 0.011 0.0186 0.0049
Onchocerca volvulus 0.0109 0.0184 0.0592
Onchocerca volvulus 0.1571 0.2923 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.011 0.0186 0.0066
Schistosoma mansoni biogenic amine receptor 0.0131 0.0225 0.0771
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Leishmania major quinonoid dihydropteridine reductase 0.011 0.0186 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.011 0.0186 0.0049
Echinococcus multilocularis transient receptor potential cation channel 0.011 0.0186 0.0635
Leishmania major dehydrogenase-like protein 0.011 0.0186 1
Onchocerca volvulus Peroxidase homolog 0.1571 0.2923 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.011 0.0186 0.2921
Echinococcus granulosus serotonin transporter 0.0109 0.0184 0.063
Brugia malayi hypothetical protein 0.0131 0.0225 0.0741
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0081 0.0277
Onchocerca volvulus 0.011 0.0186 0.0598
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0164 0.0286 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.0276 0.0906
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0018 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0206 0.0365 0.1249
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.011 0.0186 0.2921
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.011 0.0186 1
Echinococcus multilocularis g protein coupled receptor 0.0131 0.0225 0.0771
Brugia malayi neuropeptide F receptor 0.0131 0.0225 0.0741
Schistosoma mansoni opsin-like receptor 0.0131 0.0225 0.0771
Loa Loa (eye worm) hypothetical protein 0.0508 0.0932 0.3159
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0019 0.0014 0.0047
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0019 0.0014 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0186 1
Leishmania major short chain dehydrogenase/reductase, putative 0.011 0.0186 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0225 0.0771
Onchocerca volvulus 0.0131 0.0225 0.0733
Schistosoma mansoni hypothetical protein 0.0445 0.0813 0.2781
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0225 0.0771
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0131 0.0225 0.0741
Brugia malayi hypothetical protein 0.0131 0.0225 0.0741
Loa Loa (eye worm) inositol-1 0.0085 0.0138 0.0432
Echinococcus granulosus neural cadherin 0.0508 0.093 0.3182
Echinococcus multilocularis somatostatin receptor 0.0131 0.0225 0.0771
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Trypanosoma brucei short-chain dehydrogenase, putative 0.011 0.0186 1
Mycobacterium ulcerans carveol-like dehydrogenase 0.011 0.0186 0.0049
Brugia malayi hypothetical protein 0.0508 0.0932 0.3165
Schistosoma mansoni tar DNA-binding protein 0.0142 0.0245 0.0838
Brugia malayi Muscleblind-like protein 0.0158 0.0276 0.0914
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0085 0.0138 0.7232
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.011 0.0186 0.0066
Mycobacterium ulcerans short chain dehydrogenase 0.011 0.0186 0.0049
Echinococcus granulosus neuropeptide receptor 0.0131 0.0225 0.0771
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.0607 1
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.0186 0.0066
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.011 0.0186 0.0049
Leishmania major short chain dehydrogenase, putative 0.011 0.0186 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0225 0.0771
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0131 0.0225 0.0771
Mycobacterium ulcerans oxidoreductase 0.011 0.0186 0.0049
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.0606
Echinococcus multilocularis neurogenic locus notch protein 0.0508 0.093 0.3182
Mycobacterium tuberculosis Possible ketoacyl reductase 0.011 0.0186 0.0066
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.011 0.0186 0.0635
Leishmania major quinonoid dihydropteridine reductase 0.011 0.0186 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Schistosoma mansoni notch 0.0508 0.093 0.3182
Brugia malayi GCC2 and GCC3 family protein 0.0508 0.093 0.316
Schistosoma mansoni hypothetical protein 0.0206 0.0365 0.1249
Schistosoma mansoni inositol monophosphatase 0.0085 0.0138 0.0471
Loa Loa (eye worm) hypothetical protein 0.1571 0.2923 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.011 0.0186 1
Loa Loa (eye worm) TYRA-2 protein 0.0131 0.0225 0.0733
Loa Loa (eye worm) hypothetical protein 0.0508 0.0932 0.3159
Toxoplasma gondii oxidoreductase, putative 0.011 0.0186 0.1878
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0109 0.0184 0.063
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0085 0.0138 0.7232
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.0606
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0012 0.004
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.011 0.0186 0.1878
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.011 0.0186 1
Mycobacterium ulcerans short chain dehydrogenase 0.011 0.0186 0.0049
Loa Loa (eye worm) hypothetical protein 0.1571 0.2923 1
Onchocerca volvulus 0.0131 0.0225 0.0733
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Leishmania major quinonoid dihydropteridine reductase 0.011 0.0186 1
Onchocerca volvulus 0.0131 0.0225 0.0733
Trypanosoma brucei short-chain dehydrogenase, putative 0.011 0.0186 1
Schistosoma mansoni cell polarity protein 0.0508 0.093 0.3182
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.011 0.0186 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0225 0.0771
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Echinococcus granulosus g protein coupled receptor 0.0131 0.0225 0.0771
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.0606
Trypanosoma cruzi short chain dehydrogenase, putative 0.011 0.0186 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0026 0.0817
Echinococcus multilocularis neuropeptide s receptor 0.0131 0.0225 0.0771
Mycobacterium ulcerans short chain dehydrogenase 0.011 0.0186 0.0049
Trypanosoma cruzi short chain dehydrogenase, putative 0.011 0.0186 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0131 0.0225 0.0733
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0012 0.004
Schistosoma mansoni steroid dehydrogenase 0.011 0.0186 0.0635
Brugia malayi hypothetical protein 0.0131 0.0225 0.0741
Onchocerca volvulus Putative cubilin 0.0508 0.093 0.3154
Echinococcus multilocularis G protein coupled receptor 139 0.0131 0.0225 0.0771
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0019 0.0014 0.0047
Echinococcus multilocularis neurogenic locus protein delta 0.0508 0.093 0.3182
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.011 0.0186 1
Schistosoma mansoni short chain dehydrogenase 0.011 0.0186 0.0635
Schistosoma mansoni steroid dehydrogenase 0.011 0.0186 0.0635
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.0606
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.0081 0.0246
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.0606
Schistosoma mansoni amine GPCR 0.0131 0.0225 0.0771
Loa Loa (eye worm) oxidoreductase 0.011 0.0186 0.0598
Loa Loa (eye worm) hypothetical protein 0.1571 0.2923 1
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0018 0.0012 0.004
Brugia malayi EGF-like domain containing protein 0.0508 0.093 0.316
Schistosoma mansoni hypothetical protein 0.0457 0.0835 0.2857
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Echinococcus multilocularis sex peptide receptor 0.0131 0.0225 0.0771
Trichomonas vaginalis short-chain dehydrogenase, putative 0.011 0.0186 0.2921
Entamoeba histolytica hypothetical protein, conserved 0.011 0.0186 0.2921
Echinococcus multilocularis hypothetical protein 0.0018 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0081 0.0277
Brugia malayi dehydrogenases, short chain protein 2 0.011 0.0186 0.0606
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0335 0.0607 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0335 0.0607 0.6486
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Brugia malayi hypothetical protein 0.0131 0.0225 0.0741
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Onchocerca volvulus 0.0131 0.0225 0.0733
Schistosoma mansoni lozenge 0.0064 0.0098 0.0337
Echinococcus granulosus tm gpcr rhodopsin 0.0131 0.0225 0.0771
Mycobacterium ulcerans ketoacyl reductase 0.011 0.0186 0.0049
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0026 0.0713
Brugia malayi EGF-like domain containing protein 0.0508 0.093 0.316
Leishmania major quinonoid dihydropteridine reductase 0.011 0.0186 1
Onchocerca volvulus 0.0508 0.093 0.3154
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0018 0.0012 0.004
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.011 0.0186 0.0066
Echinococcus granulosus oxidoreductase 0.011 0.0186 0.0635
Loa Loa (eye worm) notch protein 0.0508 0.093 0.3154
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0225 0.0771
Onchocerca volvulus Sepiapterin reductase homolog 0.011 0.0186 0.0598
Echinococcus multilocularis fibropellin Ia 0.0508 0.093 0.3182
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.0606
Loa Loa (eye worm) neuropeptide F receptor 0.0131 0.0225 0.0733
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0131 0.0225 0.0741
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0019 0.0014 0.0047
Entamoeba histolytica short chain dehydrogenase family protein 0.011 0.0186 0.2921
Onchocerca volvulus 0.0019 0.0014 0.0007
Schistosoma mansoni steroid dehydrogenase 0.011 0.0186 0.0635
Schistosoma mansoni amine GPCR 0.0131 0.0225 0.0771
Entamoeba histolytica hypothetical protein 0.0038 0.005 0.0647
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0007
Schistosoma mansoni biogenic amine receptor 0.0131 0.0225 0.0771
Echinococcus granulosus biogenic amine 5HT receptor 0.0131 0.0225 0.0771
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Loa Loa (eye worm) RNA binding protein 0.0142 0.0245 0.0801
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0186 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Brugia malayi Protein-tyrosine phosphatase 1 0.0018 0.0012 0.0009
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.011 0.0186 0.3928
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0012 0.004
Entamoeba histolytica hypothetical protein 0.011 0.0186 0.2921
Onchocerca volvulus 0.0508 0.0932 0.3159
Echinococcus multilocularis retinol dehydrogenase 13 0.011 0.0186 0.0635
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.011 0.0186 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0206 0.0365 0.1249
Brugia malayi oxidoreductase 0.011 0.0186 0.0606
Schistosoma mansoni notch 0.0508 0.093 0.3182
Echinococcus granulosus hypothetical protein 0.011 0.0186 0.0635
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0019 0.0014 0.0047
Schistosoma mansoni short chain dehydrogenase 0.011 0.0186 0.0635
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Trypanosoma cruzi short-chain dehydrogenase, putative 0.011 0.0186 1
Brugia malayi hypothetical protein 0.0018 0.0012 0.0009
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.1878
Schistosoma mansoni opsin-like receptor 0.0131 0.0225 0.0771
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0012 0.004
Schistosoma mansoni hypothetical protein 0.0206 0.0365 0.1249
Echinococcus multilocularis dro:myosuppressin receptor 0.0131 0.0225 0.0771
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.011 0.0186 0.0635
Trichomonas vaginalis short-chain dehydrogenase, putative 0.011 0.0186 0.2921
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0131 0.0225 0.0741
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0012 0.004
Mycobacterium ulcerans short chain dehydrogenase 0.011 0.0186 0.0049
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.0606
Brugia malayi EGF-like domain containing protein 0.0508 0.093 0.316
Brugia malayi RE15519p 0.0131 0.0225 0.0741
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.0607 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.0019 0.0014 0.0047
Echinococcus multilocularis carbonyl reductase 1 0.011 0.0186 0.0635
Leishmania major hypothetical protein, conserved 0.011 0.0186 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Mycobacterium ulcerans oxidoreductase 0.011 0.0186 0.0049
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.011 0.0186 1
Brugia malayi RNA binding protein 0.0142 0.0245 0.0809
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.011 0.0186 0.0049
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.011 0.0186 0.2921
Loa Loa (eye worm) G-protein coupled receptor 0.0131 0.0225 0.0733
Onchocerca volvulus 0.011 0.0186 0.0598
Schistosoma mansoni short chain dehydrogenase 0.011 0.0186 0.0635
Mycobacterium tuberculosis Probable oxidoreductase 0.011 0.0186 0.0066
Mycobacterium ulcerans short chain dehydrogenase 0.011 0.0186 0.0049
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0019 0.0014 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.011 0.0186 0.0598
Echinococcus granulosus protein jagged 2 0.0508 0.093 0.3182
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Echinococcus granulosus neuropeptide receptor 0.0131 0.0225 0.0771
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0018 0.0012 0.004
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.011 0.0186 0.0066
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Mycobacterium tuberculosis Possible oxidoreductase 0.011 0.0186 0.0066
Echinococcus granulosus biogenic amine 5HT receptor 0.0586 0.1077 0.3684
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.011 0.0186 1
Onchocerca volvulus Neurogenic locus notch homolog 0.0508 0.093 0.3154
Schistosoma mansoni steroid dehydrogenase 0.011 0.0186 0.0635
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Schistosoma mansoni notch 0.0508 0.093 0.3182
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0018 0.0012 0.004
Loa Loa (eye worm) TAR-binding protein 0.0142 0.0245 0.0801
Loa Loa (eye worm) animal heme peroxidase 0.1571 0.2923 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.011 0.0186 0.0598
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.011 0.0186 0.0635
Schistosoma mansoni neuropeptide receptor 0.0131 0.0225 0.0771
Mycobacterium ulcerans short chain dehydrogenase 0.011 0.0186 0.0049
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.011 0.0186 0.0066
Brugia malayi EGF-like domain containing protein 0.0508 0.093 0.316
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0131 0.0225 0.0733
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.011 0.0186 0.0049
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Echinococcus multilocularis protein jagged 1 0.0508 0.093 0.3182
Leishmania major oxidoreductase-like protein 0.011 0.0186 1
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0018 0.0012 0.004
Onchocerca volvulus 0.0131 0.0225 0.0733
Onchocerca volvulus 0.011 0.0186 0.0598
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Echinococcus granulosus GPCR family 2 0.0206 0.0365 0.1249
Onchocerca volvulus 0.0131 0.0225 0.0733
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.011 0.0186 0.0598
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0142 0.0245 0.0801
Echinococcus granulosus hypothetical protein 0.011 0.0186 0.0635
Mycobacterium ulcerans short chain dehydrogenase 0.011 0.0186 0.0049
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Brugia malayi Latrophilin receptor protein 2 0.0206 0.0365 0.1221
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.011 0.0186 0.0066
Loa Loa (eye worm) animal heme peroxidase 0.1571 0.2923 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Brugia malayi Cadherin domain containing protein 0.0508 0.093 0.316
Loa Loa (eye worm) hypothetical protein 0.011 0.0186 0.0598
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.011 0.0186 0.0635
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.011 0.0186 0.0049
Leishmania major quinonoid dihydropteridine reductase 0.011 0.0186 1
Echinococcus granulosus sex peptide receptor 0.0131 0.0225 0.0771
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0131 0.0225 0.0741
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0019 0.0014 0.0047
Loa Loa (eye worm) hypothetical protein 0.011 0.0186 0.0598
Loa Loa (eye worm) hypothetical protein 0.1571 0.2923 1
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0018 0.0012 0.004
Echinococcus granulosus neurogenic locus notch protein 0.0508 0.093 0.3182
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0225 0.0771
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0225 0.0771
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.0606
Schistosoma mansoni pcd6 interacting protein-related 0.0018 0.0012 0.004
Onchocerca volvulus 0.011 0.0186 0.0598
Mycobacterium ulcerans short chain dehydrogenase 0.011 0.0186 0.0049
Brugia malayi hypothetical protein 0.0131 0.0225 0.0741
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0651 0.1199 0.4078
Brugia malayi EGF-like domain containing protein 0.0508 0.093 0.316
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0081 0.0277
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0186 1
Brugia malayi hypothetical protein 0.0025 0.0026 0.0057
Brugia malayi neuropeptide F receptor 0.0131 0.0225 0.0741
Echinococcus multilocularis G-protein coupled receptor, putative 0.0131 0.0225 0.0771
Echinococcus granulosus g protein coupled receptor 0.0131 0.0225 0.0771
Brugia malayi Animal haem peroxidase family protein 0.1571 0.2923 1
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0018 0.0012 0.0009
Echinococcus multilocularis serotonin receptor 0.0131 0.0225 0.0771
Echinococcus multilocularis neuropeptide Y receptor 0.0131 0.0225 0.0771
Echinococcus multilocularis serotonin receptor 0.0131 0.0225 0.0771
Brugia malayi Retinol dehydrogenase 12 0.011 0.0186 0.0606
Brugia malayi Dehydrogenases, short chain protein 30 0.011 0.0186 0.0606
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0225 0.0771
Toxoplasma gondii EGF family domain-containing protein 0.0508 0.093 1
Entamoeba histolytica hypothetical protein 0.0038 0.005 0.0647
Schistosoma mansoni retinal dehydrogenase 0.011 0.0186 0.0635
Loa Loa (eye worm) hypothetical protein 0.011 0.0186 0.0598
Mycobacterium ulcerans short chain dehydrogenase 0.5347 1 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0039 0.0094
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Loa Loa (eye worm) oxidoreductase 0.011 0.0186 0.0598
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Mycobacterium tuberculosis Possible oxidoreductase 0.011 0.0186 0.0066
Schistosoma mansoni sodium/chloride dependent transporter 0.0019 0.0014 0.0047
Mycobacterium ulcerans short chain dehydrogenase 0.011 0.0186 0.0049
Echinococcus granulosus g protein coupled receptor 0.0131 0.0225 0.0771
Schistosoma mansoni hypothetical protein 0.0131 0.0225 0.0771
Echinococcus granulosus somatostatin receptor 0.0131 0.0225 0.0771
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0225 0.0771
Loa Loa (eye worm) latrophilin receptor protein 2 0.0206 0.0365 0.1213
Schistosoma mansoni septate junction protein 0.0508 0.093 0.3182
Leishmania major hypothetical protein, conserved 0.011 0.0186 1
Schistosoma mansoni short chain dehydrogenase 0.011 0.0186 0.0635
Loa Loa (eye worm) hypothetical protein 0.0206 0.0365 0.1213
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.011 0.0186 0.0606
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.0606
Schistosoma mansoni carbonyl reductase 0.011 0.0186 0.0635
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0007
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0012 0.004
Echinococcus granulosus notch 0.0508 0.093 0.3182
Loa Loa (eye worm) hypothetical protein 0.0651 0.1199 0.4078
Schistosoma mansoni steroid dehydrogenase 0.011 0.0186 0.0635
Schistosoma mansoni notch 0.0508 0.093 0.3182
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0131 0.0225 0.0771
Loa Loa (eye worm) hypothetical protein 0.0109 0.0184 0.0592
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0026 0.0713
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.011 0.0186 0.0598
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0085 0.0138 0.1352
Mycobacterium ulcerans short chain dehydrogenase 0.011 0.0186 0.0049
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Loa Loa (eye worm) oxidoreductase 0.011 0.0186 0.0598
Loa Loa (eye worm) dehydrogenase 0.011 0.0186 0.0598
Loa Loa (eye worm) hypothetical protein 0.1571 0.2923 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0012 0.004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.0607 1
Echinococcus granulosus serotonin receptor 0.0131 0.0225 0.0771
Schistosoma mansoni tar DNA-binding protein 0.0142 0.0245 0.0838
Echinococcus granulosus protein jagged 1 0.0508 0.093 0.3182
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0131 0.0225 0.0733
Echinococcus granulosus protein jagged 1 0.0508 0.093 0.3182
Entamoeba histolytica hypothetical protein 0.0038 0.005 0.0647
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0131 0.0225 0.0771
Leishmania major hypothetical protein, conserved 0.011 0.0186 1
Brugia malayi Calcium binding EGF domain containing protein 0.0508 0.093 0.316
Leishmania major short chain dehydrogenase, putative 0.011 0.0186 1
Schistosoma mansoni adenoreceptor 0.0131 0.0225 0.0771
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0093 0.0863
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Mycobacterium tuberculosis Probable oxidoreductase 0.011 0.0186 0.0066
Echinococcus multilocularis muscleblind protein 0.0158 0.0276 0.0943
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0225 0.0771
Echinococcus multilocularis carbonyl reductase 1 0.011 0.0186 0.0635
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.011 0.0186 1
Schistosoma mansoni notch 0.0508 0.093 0.3182
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0131 0.0225 0.0771
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.011 0.0186 0.0635
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Echinococcus multilocularis orexin receptor type 2 0.0131 0.0225 0.0771
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0012 0.004
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0012 0.004
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0131 0.0225 0.0771
Brugia malayi hypothetical protein 0.0018 0.0012 0.0009
Brugia malayi hypothetical protein 0.011 0.0186 0.0606
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0085 0.0138 0.2112
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.011 0.0186 0.0049
Loa Loa (eye worm) hypothetical protein 0.1571 0.2923 1
Schistosoma mansoni neuropeptide receptor 0.0131 0.0225 0.0771
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0131 0.0225 0.0771
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.011 0.0186 0.0606
Brugia malayi AKH receptor 0.0131 0.0225 0.0741
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0012 0.004
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.011 0.0186 1
Brugia malayi follicle stimulating hormone receptor 0.0131 0.0225 0.0741
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0018 0.0012 0.004
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0131 0.0225 0.0733
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.011 0.0186 0.0598
Schistosoma mansoni neuropeptide f receptor 76f 0.0131 0.0225 0.0771
Mycobacterium tuberculosis Probable oxidoreductase 0.011 0.0186 0.0066
Mycobacterium ulcerans dehydrogenase/reductase 0.011 0.0186 0.0049
Brugia malayi hypothetical protein 0.0131 0.0225 0.0741
Schistosoma mansoni short chain dehydrogenase 0.011 0.0186 0.0635
Onchocerca volvulus 0.0131 0.0225 0.0733
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0225 0.0771
Schistosoma mansoni hypothetical protein 0.0131 0.0225 0.0771
Schistosoma mansoni hypothetical protein 0.0131 0.0225 0.0771
Brugia malayi EGF-like domain containing protein 0.0508 0.093 0.316
Onchocerca volvulus 0.0131 0.0225 0.0733
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0692 0.1276 0.4343
Schistosoma mansoni short chain dehydrogenase 0.011 0.0186 0.0635
Trypanosoma cruzi short-chain dehydrogenase, putative 0.011 0.0186 1
Echinococcus multilocularis notch 0.0508 0.093 0.3182
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Brugia malayi hypothetical protein 0.0018 0.0012 0.0009
Brugia malayi hypothetical protein 0.0038 0.005 0.0141
Onchocerca volvulus 0.0131 0.0225 0.0733
Echinococcus multilocularis fat cadherin tumor suppressor 0.0508 0.093 0.3182
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.011 0.0186 0.0049
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.011 0.0186 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0019 0.0014 0.0007
Echinococcus granulosus neuropeptides capa receptor 0.0131 0.0225 0.0771
Onchocerca volvulus 0.0508 0.093 0.3154
Echinococcus multilocularis protein jagged 2 0.0508 0.093 0.3182
Onchocerca volvulus Peroxidase homolog 0.1571 0.2923 1
Brugia malayi Blistered cuticle protein 3 0.1571 0.2923 1
Brugia malayi TAR-binding protein 0.0142 0.0245 0.0809
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0131 0.0225 0.0771
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0225 0.0771
Echinococcus granulosus g-protein coupled receptor 0.0131 0.0225 0.0771
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.011 0.0186 0.0066
Trypanosoma brucei short-chain dehydrogenase, putative 0.011 0.0186 1
Onchocerca volvulus 0.0131 0.0225 0.0733
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0081 0.0277
Brugia malayi sulfakinin receptor protein 0.0131 0.0225 0.0741
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Brugia malayi EGF-like domain containing protein 0.0508 0.093 0.316
Echinococcus granulosus neuropeptide receptor A26 0.0131 0.0225 0.0771
Schistosoma mansoni myosin xvIII 0.0131 0.0225 0.0771
Mycobacterium ulcerans short-chain dehydrogenase 0.011 0.0186 0.0049
Schistosoma mansoni cpg binding protein 0.0032 0.0039 0.0133
Schistosoma mansoni tar DNA-binding protein 0.0142 0.0245 0.0838
Loa Loa (eye worm) serotonin transporter b 0.0109 0.0184 0.0592
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Schistosoma mansoni peroxidasin 0.1571 0.2923 1
Onchocerca volvulus 0.0508 0.093 0.3154
Brugia malayi ORL1-like opioid receptor 0.0131 0.0225 0.0741
Loa Loa (eye worm) oxidoreductase 0.011 0.0186 0.0598
Onchocerca volvulus 0.011 0.0186 0.0598
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Trypanosoma cruzi oxidoreductase-like protein, putative 0.011 0.0186 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0026 0.0713
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0012 0.004
Leishmania major hypothetical protein, conserved 0.0025 0.0026 0.0817
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.011 0.0186 0.0066
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Schistosoma mansoni tar DNA-binding protein 0.0142 0.0245 0.0838
Loa Loa (eye worm) hypothetical protein 0.011 0.0186 0.0598
Echinococcus multilocularis Protein lozenge 0.0064 0.0098 0.0337
Brugia malayi hypothetical protein 0.0131 0.0225 0.0741
Schistosoma mansoni short chain dehydrogenase 0.011 0.0186 0.0635
Trichomonas vaginalis inositol monophosphatase, putative 0.0085 0.0138 0.2112
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Mycobacterium ulcerans short-chain dehydrogenase 0.011 0.0186 0.0049
Mycobacterium ulcerans ketoacyl reductase 0.011 0.0186 0.0049
Onchocerca volvulus 0.0032 0.0039 0.0094
Echinococcus multilocularis steroid dehydrogenase 0.011 0.0186 0.0635
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0131 0.0225 0.0771
Brugia malayi Dopamine receptor protein 2 0.0131 0.0225 0.0741
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Leishmania major short chain dehydrogenase-like protein 0.011 0.0186 1
Giardia lamblia Reductase, putative 0.011 0.0186 0.1895
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0012 0.004
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0018 0.0012 0.004
Brugia malayi Calcium binding EGF domain containing protein 0.0508 0.093 0.316
Leishmania major hypothetical protein, conserved 0.011 0.0186 1
Loa Loa (eye worm) animal heme peroxidase 0.1571 0.2923 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0131 0.0225 0.0741
Trichomonas vaginalis short-chain dehydrogenase, putative 0.011 0.0186 0.2921
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0164 0.0286 0.0167
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Onchocerca volvulus 0.0131 0.0225 0.0733
Onchocerca volvulus 0.011 0.0186 0.0598
Schistosoma mansoni steroid dehydrogenase 0.011 0.0186 0.0635
Schistosoma mansoni hypothetical protein 0.0206 0.0365 0.1249
Schistosoma mansoni short chain dehydrogenase 0.011 0.0186 0.0635
Onchocerca volvulus 0.1571 0.2923 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0586 0.1077 0.3684
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Echinococcus granulosus dro:myosuppressin receptor 0.0131 0.0225 0.0771
Echinococcus granulosus tm gpcr rhodopsin 0.0131 0.0225 0.0771
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0012 0.004
Plasmodium vivax steroid dehydrogenase, putative 0.011 0.0186 1
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.0012 0.004
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.011 0.0186 1
Loa Loa (eye worm) oxidoreductase 0.011 0.0186 0.0598
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0131 0.0225 0.0771
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.0014 0.0015
Echinococcus multilocularis 0.0018 0.0012 0.004
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0026 0.0817
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0012 0.004
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.011 0.0186 0.0066
Echinococcus multilocularis retinol dehydrogenase 11 0.011 0.0186 0.0635
Echinococcus granulosus neuropeptide FF receptor 2 0.0131 0.0225 0.0771
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Schistosoma mansoni histamine h1 receptor 0.0131 0.0225 0.0771
Loa Loa (eye worm) hypothetical protein 0.1571 0.2923 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Loa Loa (eye worm) hypothetical protein 0.1571 0.2923 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.011 0.0186 0.0049
Echinococcus granulosus muscleblind protein 0.0158 0.0276 0.0943
Loa Loa (eye worm) neuropeptide F receptor 0.0131 0.0225 0.0733
Mycobacterium ulcerans short chain dehydrogenase 0.011 0.0186 0.0049
Brugia malayi notch-like transmembrane receptor 0.0508 0.093 0.316
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.0014 0.0015
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0131 0.0225 0.0733
Echinococcus granulosus sodium and chloride dependent glycine 0.0019 0.0014 0.0047
Schistosoma mansoni hypothetical protein 0.0131 0.0225 0.0771
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0085 0.0138 0.7232
Brugia malayi Protein-tyrosine phosphatase 0.0018 0.0012 0.0009
Echinococcus multilocularis neuropeptides capa receptor 0.0131 0.0225 0.0771
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0692 0.1276 0.4347
Onchocerca volvulus 0.0131 0.0225 0.0733
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0225 0.0771
Echinococcus granulosus carbonyl reductase 1 0.011 0.0186 0.0635
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.0012 0.004
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Trichomonas vaginalis short-chain dehydrogenase, putative 0.011 0.0186 0.2921
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0225 0.0771
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.011 0.0186 0.2921
Echinococcus granulosus G protein coupled receptor 139 0.0131 0.0225 0.0771
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.011 0.0186 1
Schistosoma mansoni hypothetical protein 0.0508 0.093 0.3182
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0026 0.0134
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.011 0.0186 0.0606
Plasmodium vivax hypothetical protein, conserved 0.011 0.0186 1
Loa Loa (eye worm) blistered cuticle protein 3 0.1571 0.2923 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.0606
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Echinococcus multilocularis neuropeptide receptor A26 0.0131 0.0225 0.0771
Treponema pallidum fructose-bisphosphate aldolase 0.0335 0.0607 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.0014 0.0047
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.0014 0.0047
Echinococcus multilocularis steroid dehydrogenase 0.011 0.0186 0.0635
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.0606
Echinococcus granulosus orexin receptor type 2 0.0131 0.0225 0.0771
Schistosoma mansoni short chain dehydrogenase 0.011 0.0186 0.0635
Onchocerca volvulus 0.011 0.0186 0.0598
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0018 0.0012 0.004
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.005 0.0172
Onchocerca volvulus 0.011 0.0186 0.0598
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.011 0.0186 0.0635
Onchocerca volvulus Peroxidasin homolog 0.1571 0.2923 1
Loa Loa (eye worm) oxidoreductase 0.011 0.0186 0.0598
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0018 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.011 0.0186 0.0066
Echinococcus multilocularis g-protein coupled receptor 0.0131 0.0225 0.0771
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0131 0.0225 0.0771
Schistosoma mansoni neuropeptide receptor 0.0131 0.0225 0.0771
Schistosoma mansoni sodium/chloride dependent transporter 0.0019 0.0014 0.0047
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0018 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0007
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0131 0.0225 0.0771
Echinococcus granulosus neuropeptide Y receptor 0.0131 0.0225 0.0771
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Loa Loa (eye worm) oxidoreductase 0.011 0.0186 0.0598
Echinococcus granulosus peptide allatostatin:somatostatin 0.0131 0.0225 0.0771
Entamoeba histolytica hypothetical protein 0.0038 0.005 0.0647
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.0014 0.0015
Schistosoma mansoni short chain dehydrogenase 0.011 0.0186 0.0635
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0131 0.0225 0.0771
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.0606
Brugia malayi G-protein coupled receptor 0.0131 0.0225 0.0741
Loa Loa (eye worm) hypothetical protein 0.1571 0.2923 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0131 0.0225 0.0771
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.011 0.0186 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0206 0.0365 0.1221
Echinococcus multilocularis peroxidasin 0.1571 0.2923 1
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.011 0.0186 0.0066
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0019 0.0014 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0225 0.0771
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0012 0.004
Schistosoma mansoni neuropeptide F-like receptor 0.0131 0.0225 0.0771
Giardia lamblia High cysteine protein 0.0508 0.093 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0131 0.0225 0.0771
Echinococcus multilocularis allatostatin A receptor 0.0131 0.0225 0.0771
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.011 0.0186 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0131 0.0225 0.0733
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0335 0.0607 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0586 0.1077 0.3684
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0106 0.0364
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.011 0.0186 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.0109 0.0184 0.0592
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0019 0.0014 0.0047
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.0607 1
Onchocerca volvulus Slit protein homolog 0.0508 0.093 0.3154
Onchocerca volvulus 0.011 0.0186 0.0598
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Onchocerca volvulus 0.0131 0.0225 0.0733
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0012 0.004
Leishmania major 3-keto-dihydrosphingosine reductase 0.011 0.0186 1
Onchocerca volvulus 0.011 0.0186 0.0598
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0049
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.0014 0.0047
Brugia malayi Melatonin receptor type 1A 0.0131 0.0225 0.0741
Brugia malayi hypothetical protein 0.1571 0.2923 1
Schistosoma mansoni amine GPCR 0.0131 0.0225 0.0771
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0225 0.0771
Brugia malayi Calcitonin receptor-like protein seb-1 0.0651 0.1199 0.4083
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.011 0.0186 1
Loa Loa (eye worm) runx1 0.0064 0.0098 0.0297
Mycobacterium tuberculosis Probable oxidoreductase 0.011 0.0186 0.0066
Brugia malayi CXXC zinc finger family protein 0.0032 0.0039 0.0102
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.011 0.0186 0.0635
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.011 0.0186 0.0049
Echinococcus multilocularis sodium and chloride dependent glycine 0.0019 0.0014 0.0047
Entamoeba histolytica hypothetical protein, conserved 0.011 0.0186 0.2921
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0186 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0131 0.0225 0.0771
Echinococcus granulosus carbonyl reductase 1 0.011 0.0186 0.0635
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.0014 0.0047
Entamoeba histolytica short chain dehydrogenase family protein 0.011 0.0186 0.2921
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0081 0.0277
Onchocerca volvulus 0.0131 0.0225 0.0733
Echinococcus granulosus protein jagged 2 0.0508 0.093 0.3182
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Echinococcus granulosus peroxidasin 0.1571 0.2923 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.0606
Loa Loa (eye worm) hypothetical protein 0.1571 0.2923 1
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.011 0.0186 1
Onchocerca volvulus Peroxidasin homolog 0.1571 0.2923 1
Echinococcus granulosus neurogenic locus protein delta 0.0508 0.093 0.3182
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.011 0.0186 0.0635
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.0081 0.0237
Echinococcus multilocularis retinol dehydrogenase 11 0.011 0.0186 0.0635
Echinococcus multilocularis protein jagged 1 0.0508 0.093 0.3182
Trichomonas vaginalis short-chain dehydrogenase, putative 0.011 0.0186 0.2921
Loa Loa (eye worm) hypothetical protein 0.1571 0.2923 1
Echinococcus granulosus dnaJ subfamily B 0.0457 0.0835 0.2857
Mycobacterium ulcerans short chain dehydrogenase 0.011 0.0186 0.0049
Echinococcus granulosus retinol dehydrogenase 11 0.011 0.0186 0.0635
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0225 0.0771
Onchocerca volvulus 0.011 0.0186 0.0598
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0007
Onchocerca volvulus 0.0019 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0109 0.0184 0.0592
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.011 0.0186 0.3928
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.011 0.0186 0.0635
Schistosoma mansoni hypothetical protein 0.0508 0.093 0.3182
Schistosoma mansoni alpha-1 adrenergic receptor 0.0131 0.0225 0.0771
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0019 0.0014 0.0015
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0012 0.004
Echinococcus multilocularis conserved hypothetical protein 0.011 0.0186 0.0635
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0131 0.0225 0.0771
Toxoplasma gondii oxidoreductase, putative 0.011 0.0186 0.1878
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.011 0.0186 0.0066
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.0607 1
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Brugia malayi Dehydrogenases, short chain protein 2 0.011 0.0186 0.0606
Onchocerca volvulus Dual oxidase homolog 0.1571 0.2923 1
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.011 0.0186 1
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0508 0.093 0.316
Echinococcus granulosus sodium and chloride dependent glycine 0.0019 0.0014 0.0047
Brugia malayi Protein-tyrosine phosphatase 0.0018 0.0012 0.0009
Brugia malayi GnHR receptor homolog 0.0131 0.0225 0.0741
Loa Loa (eye worm) hypothetical protein 0.0158 0.0276 0.0906
Brugia malayi RNA recognition motif domain containing protein 0.0142 0.0245 0.0809
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0225 0.0771
Loa Loa (eye worm) oxidoreductase 0.011 0.0186 0.0598
Echinococcus granulosus neurogenic locus notch protein 0.0508 0.093 0.3182
Mycobacterium ulcerans ketoacyl reductase 0.011 0.0186 0.0049
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Brugia malayi larval opioid receptor 0.0131 0.0225 0.0741
Echinococcus multilocularis neuropeptide FF receptor 2 0.0131 0.0225 0.0771
Plasmodium falciparum steroid dehydrogenase, putative 0.011 0.0186 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.1878
Schistosoma mansoni sodium/chloride dependent transporter 0.0109 0.0184 0.063
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.011 0.0186 0.1878
Onchocerca volvulus Chorion peroxidase homolog 0.1571 0.2923 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0186 0.0598
Echinococcus multilocularis neurogenic locus protein delta 0.0508 0.093 0.3182
Echinococcus multilocularis g protein coupled receptor 0.0131 0.0225 0.0771
Trypanosoma brucei oxidoreductase-like protein 0.011 0.0186 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0012 0.004
Brugia malayi Dopamine receptor protein 1 0.0131 0.0225 0.0741
Loa Loa (eye worm) hypothetical protein 0.0109 0.0184 0.0592
Echinococcus multilocularis inositol monophosphatase 1 0.0085 0.0138 0.0471
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.1878
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.011 0.0186 0.0066
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.0606
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.011 0.0186 0.2921
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.0606
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0012 0.004
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0018 0.0012 0.004
Leishmania major quinonoid dihydropteridine reductase 0.011 0.0186 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Echinococcus multilocularis carbonyl reductase 1 0.011 0.0186 0.0635
Trichomonas vaginalis short-chain dehydrogenase, putative 0.011 0.0186 0.2921
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0692 0.1276 0.4365
Schistosoma mansoni steroid dehydrogenase 0.011 0.0186 0.0635
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0085 0.0138 0.7232
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0007
Schistosoma mansoni carbonyl reductase 0.011 0.0186 0.0635
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.011 0.0186 0.0066
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0131 0.0225 0.0771
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0206 0.0365 0.1249
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.011 0.0186 0.1895
Trichomonas vaginalis short-chain dehydrogenase, putative 0.011 0.0186 0.2921
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.011 0.0186 0.1878
Brugia malayi Animal haem peroxidase family protein 0.1571 0.2923 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.1571 0.2923 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0081 0.0277
Loa Loa (eye worm) norepinephrine transporter 0.0109 0.0184 0.0592
Schistosoma mansoni short chain dehydrogenase 0.011 0.0186 0.0635
Leishmania major pteridine reductase 1 0.011 0.0186 1
Brugia malayi putative neuropeptide receptor NPR1 0.0131 0.0225 0.0741
Mycobacterium ulcerans short-chain dehydrogenase 0.011 0.0186 0.0049
Echinococcus granulosus carbonyl reductase 1 0.011 0.0186 0.0635
Echinococcus multilocularis neuropeptide Y receptor 0.0131 0.0225 0.0771
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Toxoplasma gondii carbonyl reductase 1, putative 0.011 0.0186 0.1878
Mycobacterium ulcerans short chain dehydrogenase 0.011 0.0186 0.0049
Loa Loa (eye worm) oxidoreductase 0.011 0.0186 0.0598
Brugia malayi G protein-coupled receptor 0.0131 0.0225 0.0741
Loa Loa (eye worm) dehydrogenase 0.011 0.0186 0.0598
Mycobacterium ulcerans dehydrogenase 0.011 0.0186 0.0049
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0012 0.004
Schistosoma mansoni neuropeptide F-like receptor 0.0131 0.0225 0.0771
Brugia malayi Dopamine receptor 0.0131 0.0225 0.0741
Schistosoma mansoni inositol monophosphatase 0.0085 0.0138 0.0471
Mycobacterium ulcerans short chain dehydrogenase 0.011 0.0186 0.0049
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0131 0.0225 0.0771
Echinococcus granulosus neuropeptide s receptor 0.0131 0.0225 0.0771
Schistosoma mansoni slit 0.0508 0.093 0.3182
Trichomonas vaginalis short-chain dehydrogenase, putative 0.011 0.0186 0.2921
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.011 0.0186 0.2921
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0007
Brugia malayi hypothetical protein 0.0018 0.0012 0.0009
Leishmania major short chain dehydrogenase/reductase, putative 0.011 0.0186 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.011 0.0186 0.0049
Onchocerca volvulus 0.0131 0.0225 0.0733
Trypanosoma brucei short-chain dehydrogenase, putative 0.011 0.0186 1
Echinococcus multilocularis oxidoreductase 0.011 0.0186 0.0635
Trypanosoma brucei short-chain dehydrogenase, putative 0.011 0.0186 1
Brugia malayi Muscle positioning protein 4 0.0508 0.093 0.316
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.005 0.0172
Trichomonas vaginalis steroid dehydrogenase, putative 0.011 0.0186 0.2921
Echinococcus granulosus neuropeptide Y receptor 0.0131 0.0225 0.0771
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.1878
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0085 0.0138 0.2112
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.011 0.0186 0.0635
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.0607 1
Echinococcus multilocularis carbonyl reductase 1 0.011 0.0186 0.0635
Loa Loa (eye worm) Notch2 0.0508 0.093 0.3154
Schistosoma mansoni carbonyl reductase 0.011 0.0186 0.0635
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.011 0.0186 0.2921
Brugia malayi hypothetical protein 0.0019 0.0014 0.0015
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.011 0.0186 0.0049
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Echinococcus multilocularis neurogenic locus notch protein 0.0508 0.093 0.3182
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.011 0.0186 0.0066
Leishmania major hypothetical protein, conserved 0.011 0.0186 1
Loa Loa (eye worm) animal heme peroxidase 0.1571 0.2923 1
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Loa Loa (eye worm) hypothetical protein 0.0445 0.0813 0.2752
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0692 0.1276 0.4365
Giardia lamblia Short-chain dehydrogenase, putative 0.011 0.0186 0.1895
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0225 0.0771
Echinococcus granulosus retinol dehydrogenase 11 0.011 0.0186 0.0635
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Echinococcus granulosus delta-like protein 1 0.0508 0.093 0.3182
Brugia malayi Peroxidasin 0.1571 0.2923 1
Mycobacterium ulcerans short chain dehydrogenase 0.011 0.0186 0.0049
Echinococcus multilocularis tar DNA binding protein 0.0142 0.0245 0.0838
Schistosoma mansoni hypothetical protein 0.0508 0.093 0.3182
Onchocerca volvulus 0.0508 0.093 0.3154
Schistosoma mansoni short chain dehydrogenase 0.011 0.0186 0.0635
Onchocerca volvulus 0.011 0.0186 0.0598
Echinococcus multilocularis neural cadherin 0.0508 0.093 0.3182
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0012 0.004
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0012 0.004
Schistosoma mansoni steroid dehydrogenase 0.011 0.0186 0.0635
Echinococcus granulosus fibropellin Ia 0.0508 0.093 0.3182
Schistosoma mansoni tar DNA-binding protein 0.0142 0.0245 0.0838
Schistosoma mansoni amine GPCR 0.0131 0.0225 0.0771
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.011 0.0186 0.0635
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.005 0.0172
Echinococcus multilocularis fmrfamide receptor 0.0131 0.0225 0.0771
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0131 0.0225 0.0771
Echinococcus granulosus tar DNA binding protein 0.0142 0.0245 0.0838
Loa Loa (eye worm) hypothetical protein 0.1571 0.2923 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0012 0.004
Echinococcus multilocularis serotonin transporter 0.0109 0.0184 0.063
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0651 0.1199 0.4083
Echinococcus multilocularis neuropeptide receptor 0.0131 0.0225 0.0771
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0225 0.0771
Brugia malayi putative neuropeptide receptor 0.0131 0.0225 0.0741
Schistosoma mansoni hypothetical protein 0.0508 0.093 0.3182
Echinococcus granulosus inositol monophosphatase 1 0.0085 0.0138 0.0471
Mycobacterium ulcerans short chain dehydrogenase 0.011 0.0186 0.0049
Schistosoma mansoni steroid dehydrogenase 0.011 0.0186 0.0635
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0131 0.0225 0.0771
Brugia malayi G-protein coupled receptor 0.0131 0.0225 0.0741
Echinococcus multilocularis dnaJ subfamily B 0.0457 0.0835 0.2857
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0206 0.0365 0.1249
Onchocerca volvulus 0.0131 0.0225 0.0733
Loa Loa (eye worm) melatonin receptor type 1A 0.0131 0.0225 0.0733
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.0607 1
Brugia malayi Animal haem peroxidase family protein 0.1571 0.2923 1
Onchocerca volvulus 0.0131 0.0225 0.0733
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.1878
Mycobacterium ulcerans short chain dehydrogenase 0.011 0.0186 0.0049
Brugia malayi latrophilin 2 splice variant baaae 0.0445 0.0813 0.2758
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.011 0.0186 0.0049
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0131 0.0225 0.0771
Loa Loa (eye worm) hypothetical protein 0.0131 0.0225 0.0733
Brugia malayi Inositol-1 0.0085 0.0138 0.044
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0018 0.0012 0.004
Echinococcus granulosus WW domain containing oxidoreductase 0.011 0.0186 0.0635
Schistosoma mansoni biogenic amine receptor 0.0131 0.0225 0.0771
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0012 0.004
Mycobacterium ulcerans short chain dehydrogenase 0.011 0.0186 0.0049
Loa Loa (eye worm) hypothetical protein 0.1571 0.2923 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0018 0.0012 0.004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.0606
Echinococcus multilocularis fmrfamide receptor 0.0131 0.0225 0.0771
Echinococcus multilocularis slit 2 protein 0.0508 0.093 0.3182
Brugia malayi hypothetical protein 0.0131 0.0225 0.0741
Loa Loa (eye worm) hypothetical protein 0.011 0.0186 0.0598
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0131 0.0225 0.0771
Schistosoma mansoni hypothetical protein 0.0038 0.005 0.0172
Schistosoma mansoni hypothetical protein 0.0508 0.093 0.3182
Loa Loa (eye worm) hypothetical protein 0.011 0.0186 0.0598
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0131 0.0225 0.0771
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0508 0.093 0.3182
Echinococcus granulosus neuropeptides capa receptor 0.0131 0.0225 0.0771
Brugia malayi dehydrogenases, short chain protein 9 0.011 0.0186 0.0606
Schistosoma mansoni opsin-like receptor 0.0131 0.0225 0.0771
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0018 0.0012 0.004
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0018 0.0012 0.004
Echinococcus granulosus 7tm_1 domain containing protein 0.0131 0.0225 0.0771
Echinococcus multilocularis sodium and chloride dependent glycine 0.0019 0.0014 0.0047
Schistosoma mansoni cpg binding protein 0.0034 0.0042 0.0145
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.011 0.0186 0.3928
Schistosoma mansoni laminin gamma-3 chain 0.0508 0.093 0.3182
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0019 0.0014 0.0047
Echinococcus granulosus carbonyl reductase 1 0.011 0.0186 0.0635
Brugia malayi Cadherin domain containing protein 0.0508 0.093 0.316
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0131 0.0225 0.0771
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0131 0.0225 0.0771
Echinococcus granulosus 7TM GPCR rhodopsin 0.0131 0.0225 0.0771
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0018 0.0012 0.004
Brugia malayi Animal haem peroxidase family protein 0.1571 0.2923 1
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.011 0.0186 0.2921
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0131 0.0225 0.0771
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0109 0.0184 0.06
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.0606
Schistosoma mansoni peroxidasin 0.1571 0.2923 1
Echinococcus granulosus hypothetical protein 0.0131 0.0225 0.0771
Mycobacterium ulcerans short-chain dehydrogenase 0.011 0.0186 0.0049
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.011 0.0186 0.0606
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0131 0.0225 0.0741
Onchocerca volvulus 0.0019 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Brugia malayi hypothetical protein 0.0131 0.0225 0.0741
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0007
Schistosoma mansoni amine GPCR 0.0131 0.0225 0.0771
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0692 0.1276 0.4365
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0012 0.0009
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.011 0.0186 0.0598
Echinococcus multilocularis neuropeptide receptor 0.0131 0.0225 0.0771
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0012 0.004
Brugia malayi hypothetical protein 0.0018 0.0012 0.0009
Echinococcus multilocularis cpg binding protein 0.0034 0.0042 0.0145
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.0508 0.093 0.3154
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.011 0.0186 0.0066
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0131 0.0225 0.0771
Mycobacterium ulcerans short chain dehydrogenase 0.011 0.0186 0.0049
Schistosoma mansoni hypothetical protein 0.0508 0.093 0.3182
Mycobacterium ulcerans short-chain type oxidoreductase 0.011 0.0186 0.0049
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0508 0.093 0.3154
Schistosoma mansoni short chain dehydrogenase 0.011 0.0186 0.0635
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.011 0.0186 0.3928
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.0012 0.004
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0085 0.0138 0.2112
Schistosoma mansoni hypothetical protein 0.0508 0.093 0.3182

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 3.5 nM Ability to displace [3H]-pyrilamine from human cloned histamine H1 receptor expressed in CHO cells ChEMBL. 15125929
Ki (binding) = 15.9 nM Ability to displace [3H]- mesulergine from human cloned 5-hydroxytryptamine 2C receptor expressed in CHO cells ChEMBL. 15125929
Ki (binding) = 74.1 nM Ability to displace [125I]-R91150 from human cloned 5-hydroxytryptamine 2A receptor expressed in L929 cells ChEMBL. 15125929

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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