Detailed view for TcCLB.509693.50

Basic information

TDR Targets ID: 43778
Trypanosoma cruzi, metallo-peptidase, Clan MG, Family M24
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.1019 | Length (AA): 476 | MW (Da): 52914 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00557   Metallopeptidase family M24

Gene Ontology

Mouse over links to read term descriptions.
GO:0004177   aminopeptidase activity  
GO:0008235   metalloexopeptidase activity  
GO:0006508   proteolysis  
GO:0009987   cellular process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
10 472 2iw2 (A) 20 468 12.00 0 1 0.66 1.1
111 476 1b6a () 110 478 62.00 0 1 1.57 -1.18
111 476 1b6a (A) 110 478 62.00 0 1 1.56141 -1.09
156 476 3fm3 (A) 36 358 42.00 0 1 1.26987 -0.92

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127231)

Species Accession Gene Product
Arabidopsis thaliana AT2G44180   methionine aminopeptidase 2A
Arabidopsis thaliana AT3G59990   methionine aminopeptidase 2B
Babesia bovis BBOV_III002280   methionine aminopeptidase, type II family protein
Brugia malayi Bm1_37925   initiation factor 2-associated protein.
Candida albicans CaO19.1214   methionine aminopeptidase
Candida albicans CaO19.8802   methionine aminopeptidase
Caenorhabditis elegans CELE_Y116A8A.9   Protein MAP-2, isoform C
Cryptosporidium hominis Chro.20263   methionine aminopeptidase, type II
Cryptosporidium parvum cgd2_2480   methionine aminopeptidase, type II, putative , an1 domain
Dictyostelium discoideum DDB_G0270264   methionine aminopeptidase 2
Drosophila melanogaster Dmel_CG4008   uninitiated
Echinococcus granulosus EgrG_000820900   methionyl aminopeptidase 2
Entamoeba histolytica EHI_126880   methionine aminopeptidase, putative
Echinococcus multilocularis EmuJ_000820900   methionyl aminopeptidase 2
Giardia lamblia GL50803_86600   Methionine aminopeptidase
Homo sapiens ENSG00000111142   methionyl aminopeptidase 2
Leishmania braziliensis LbrM.21.0950   methionine aminopeptidase 2, putative
Leishmania donovani LdBPK_210960.1   metallo-peptidase, Clan MG, Family M24
Leishmania infantum LinJ.21.0960   methionine aminopeptidase 2, putative
Leishmania major LmjF.21.0840   methionine aminopeptidase 2, putative
Leishmania mexicana LmxM.21.0840   methionine aminopeptidase 2, putative
Loa Loa (eye worm) LOAG_02879   initiation factor 2-associated protein
Mus musculus ENSMUSG00000036112   methionine aminopeptidase 2
Neospora caninum NCLIV_043950   hypothetical protein
Oryza sativa 4346194   Os08g0542000
Oryza sativa 4352851   Os12g0628500
Onchocerca volvulus OVOC4299   Methionine aminopeptidase 2 homolog
Plasmodium berghei PBANKA_1010200   methionine aminopeptidase 2, putative
Plasmodium falciparum PF3D7_1434600   methionine aminopeptidase 2
Plasmodium knowlesi PKNH_0421200   methionine aminopeptidase 2, putative
Plasmodium vivax PVX_084805   methionine aminopeptidase 2, putative
Plasmodium yoelii PY02559   methionine aminopeptidase, type II, putative
Saccharomyces cerevisiae YBL091C   Map2p
Schistosoma japonicum Sjp_0009900   ko:K01265 methionyl aminopeptidase [EC3.4.11.18], putative
Schistosoma mansoni Smp_011120   methionyl aminopeptidase 2 (M24 family)
Schmidtea mediterranea mk4.001040.10   Methionine aminopeptidase 2
Trypanosoma brucei gambiense Tbg972.10.1620   methionine aminopeptidase 2, putative,metallo- peptidase, Clan MG, Family M24
Trypanosoma brucei Tb927.10.1420   metallo-peptidase, Clan MG, Family M24
Trypanosoma brucei Tb11.v5.0783   methionine aminopeptidase 2, putative
Trypanosoma congolense TcIL3000_10_1210   metallo-peptidase, Clan MG, Family M24
Trypanosoma cruzi TcCLB.509693.50   metallo-peptidase, Clan MG, Family M24
Trypanosoma cruzi TcCLB.506457.10   metallo-peptidase, Clan MG, Family M24
Toxoplasma gondii TGME49_305460   methionine aminopeptidase 2, putative
Theileria parva TP03_0593   methionine aminopeptidase, type II, putative
Trichomonas vaginalis TVAG_190580   Clan MG, familly M24, aminopeptidase P-like metallopeptidase
Trichomonas vaginalis TVAG_476160   Clan MG, familly M24, aminopeptidase P-like metallopeptidase
Trichomonas vaginalis TVAG_410220   Clan MG, familly M24, aminopeptidase P-like metallopeptidase
Trichomonas vaginalis TVAG_317020   Clan MG, familly M24, aminopeptidase P-like metallopeptidase

Essentiality

TcCLB.509693.50 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.1420 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.1420 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.1420 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.1420 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y116A8A.9 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y116A8A.9 Caenorhabditis elegans slow growth wormbase
PBANKA_1010200 Plasmodium berghei Essential plasmo
TGME49_305460 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.6

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens methionyl aminopeptidase 2 Compounds References
Mus musculus methionine aminopeptidase 2 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Staphylococcus aureus (strain COL) Methionine aminopeptidase 252 aa 24.2% 223 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0056375 0.406794 0
0.0707 0.5 0.5
0.0504 1 1
0.0499 1 1
0.0621 0.5 0.5
0.0191 1 1
0.0328 1 1
0.0433 1 1
0.0053 0.5 0.5
0.0579 0.7306 1
0.049 1 1
0.0497 1 1
0.0841 0.5 0.5
0.0314 0.347 1
0.0378 0.3363 1
0.054 1 1
0.079 1 1
0.0053 1 0.5
0.0053 0.5 0.5
0.0187 0.3074 0.5
0.046 0.5 0.5
0.0105 1 0.5
0.062 1 1
0.1418 1 1
0.0285 1 1
0.0089 0.3874 1
0.0145 1 1
0.2097 1 1
0.0086 1 1
0.114 0.3121 1
0.0405 1 1
0.0269 0.7366 1
0.0368 1 1
0.0053 0.5 0.5
0.0053 0.5 0.5
0.0053 0.5 0.5
0.0982 0.8077 0.8035
0.0268 0.8881 1
0.0053 0.5 0.5
0.2211 1 1
0.0353 0.3279 1
0.0536 1 0.5
0.0189 0.4605 1
0.0053 0.5 0.5
0.0538 0.3171 0.7441
0.0053 0.5 0.5
0.0575 0.5997 1
0.0411 0.5581 1
0.1114 1 0.5
0.0139 0.5 0.5
0.0708 1 0.5
0.1228 1 0.5
0.033 0.5 0.5
0.0184 0.8578 1
0.083 1 1
0.2288 1 1
0.0053 0.484 0.484
0.1273 1 1
0.0331 0.5 0.5
0.1467 1 1
0.0944 1 0.5
0.0044 1 1
0.0056 0.8012 0
0.0048 0.257 0
0.0138 1 1
0.0055 0.9034 0.9034
0.0263 1 0.5
0.2195 0.6206 1
0.0048 0.8012 0
0.0324 0.338 1
0.1507 1 1
0.0053 1 0.5
0.0053 0.5 0.5
0.0043 0.4044 0.4013
0.0353 0.3279 1
0.0282 1 1
0.0369 0.3981 1
0.0264 1 1
0.0181 1 1
0.0478 1 1
0.0325 1 0.5
0.0613 1 1
0.2314 0.8106 1
0.1994 1 1
0.0366 0.5 0.5
0.0328 0.6092 1
0.0319 0.3507 1
0.0051 0.8012 0
0.2278 1 1
0.0191 1 1
0.2001 1 0.5
0.0319 0.3507 1
0.0047 0.7744 1
0.0289 1 1
0.2362 1 0.5
0.022 1 1
0.1858 1 1
0.047 1 1
0.0265 0.8451 1
0.0613 1 1
0.0571 1 0.5
0.0414 1 1
0.0797 1 1
0.2065 1 1
0.0088 0.2577 1
0.0053 0.5 0.5
0.1467 1 1
0.0284 0.3191 1
0.2148 0.5 0.5
0.0324 0.3802 0.8841
0.0043 0.965 0
0.0726 1 1
0.0053 0.5 0.5
0.0053 0.5 0.5
0.0053 0.8682 1
0.0053 0.5 0.5
0.1048 1 1
0.0046 0.3456 0.9209
0.1325 0.7288 1
0.0419 1 1
0.0144 0.5 0.5
0.0414 1 0.5
0.047 1 1
0.0397 1 0.5
0.1229 0.5 0.5
0.0445 1 0.5
0.0418 1 1
0.0053 0.5 0.5
0.0284 0.3191 1
0.0362 1 1
0.2314 0.8106 1
0.0242 1 1
0.3865 1 1
0.0613 1 1
0.0372 0.5 0.5
0.0053 0.5 0.5
0.1327 1 1
0.0336 0.3083 1
0.1325 0.7288 1
0.0053 0.5 0.5
0.0273 1 1
0.1334 1 1
0.0089 1 1
0.0183 0.4202 1
0.2022 1 1
0.0053 0.8682 1
0.0712 1 1
0.2773 1 1
0.0598 1 1
0.1334 1 1
0.0043 1 1
0.0178 0.2947 1
0.0091 0.4116 0.5
0.0364 1 1
0.0957 1 1
0.0324 0.338 1
0.0057 0.5803 0
0.0375 1 0.5
0.1782 1 1
0.1334 1 1
0.0053 0.5 0.5
0.0053 0.5 0.5
0.0172 0.579 1
0.00758624 1 1
0.0411 1 1
0.0629 1 1
0.0328 0.6092 1
0.0053 0.5 0.5
0.009 1 0.5
0.0336 0.3083 1
0.0136 0.4542 1
0.0621 1 1
0.0053 0.5 0.5
0.1116 1 1
0.0053 0.5 0.5
0.2267 1 1
0.0053 0.5 0.5
0.0707 0.5 0.5
0.0053 0.5 0.5
0.4646 0.2663 0.6851
0.0308 0.5209 1
0.2195 0.6206 1
0.0594 0.4913 1
0.0594 0.4913 1
0.0662 1 1
0.0629 0.7977 1
0.0613 1 1
0.2065 1 1
0.0053 0.5 0.5
0.0662 1 1
0.0355 0.8129 0.5
0.00566906 0.454251 0.5
0.005 1 0.5
0.0862 0.9134 1
0.1782 1 1
0.0477 1 1
0.0179 0.5 0.5
0.0638 1 1
0.0053 0.5 0.5
0.0053 0.5 0.5
0.0225 1 1
0.0098 1 1
0.0224 0.6437 0.5722
0.1996 0.4404 1
0.0346 1 1
0.0461 0.5443 1
0.1507 1 1
0.0411 1 1
0.0838 1 1
0.0346 1 1
0.0053 0.5 0.5
0.1254 1 1
0.049 1 1
0.0319 1 1
0.0414 1 1
0.0193 0.5 0.5
0.0613 1 1
0.0528 1 1
0.0047 0.8012 0
0.0329 0.3154 1
0.0142 1 0.5
0.0052 0.5 0.5
0.0401 0.271 1
0.0053 0.5 0.5
0.2097 1 1
0.2208 0.5 0.5
0.0101 1 1
0.0868 0.9825 1
0.0613 1 1
0.0727 1 1
0.0629 1 1
0.1991 0.4775 1
0.0053 0.5 0.5
0.0222 1 1
0.0477 1 1
0.0456 1 1
0.0542 1 1
0.2204 1 1
0.023 1 1
0.0618 0.5 0.5
0.0086 0.5704 1
0.0059 0.3744 0.5428
0.0629 1 1
0.0626 0.3907 1
0.0982 0.8077 0.8035
0.0581 0.7334 1
0.0417 0.3258 1
0.0747 0.9138 0
0.0232 1 1
0.290502 1 1
0.1212 1 1
0.0594 0.4913 1
0.0052 0.9034 0.9034
0.0671 1 1
0.1228 1 0.5
0.0097 1 0.5
0.0144 1 1
0.0951 0.5246 1
0.0493 0.5 0.5
0.005 1 1
0.2097 1 1
0.0146 1 1
0.0103 0.8012 0
0.0274 0.483 1
0.0982 0.8077 0.8035
0.0982 0.8077 0.8035
0.032 0.3675 1
0.0761 1 1
0.0086 1 1
0.0268 0.9318 1
0.0364 1 1
0.0324 0.338 1
0.0059 1 1
0.1852 1 1
0.0202 1 1
0.0575 1 1
0.0191 0.5 0.5
0.0628 1 0.5
0.1991 0.4775 1
0.0087 0.4095 1
0.0056375 0.406794 0
0.0185 1 1
0.0043 0.4044 0.4013
0.018 1 1
0.0179 0.5 0.5
0.0099 1 1
0.18 1 0.5
0.0273 0.3193 1
0.0363 0.7799 1
0.0359 0.5 0.5
0.0284 0.3191 1
0.0645 1 1
0.042 1 0.5
0.0449 0.3836 0.6774
0.0053 0.5 0.5
0.0183 0.4202 1
0.0551 1 1
0.0229 1 1
0.0797 1 1
0.0136 0.942 1
0.0626 0.3907 1
0.0057 0.8606 0
0.0086 0.313 1
0.0091 0.2871 1
0.0053 0.3658 0.5
0.0577 1 0.5
0.0174 0.353 1
0.0053 1 0.5
0.0633 1 1
0.2097 1 1
0.0707 0.5 0.5
0.0053 0.5 0.5
0.0289 0.3149 1
0.0314 0.347 1
0.1852 1 1
0.048 1 1
0.1523 1 1
0.2195 0.6206 1
0.0179 1 1
0.005 0.8682 0.773
0.3865 1 1
0.1229 0.5 0.5
0.0088 0.2577 1
0.0316 0.3467 1
0.3569 0.6788 1
0.0449 1 1
0.0269 0.7447 1
0.0103 1 1
0.0304 1 1
0.0264 0.2615 1
0.00758624 1 1
0.0144 0.449 1
0.0409 1 1
0.0199 1 1
0.0053 0.5 0.5
0.1141 0.5 0.5
0.290502 1 1
0.0057 0.8606 0
0.0611 0.5 0.5
0.0053 0.5 0.5
0.0177 0.874 0
0.0089 1 1
0.1334 1 1
0.364019 1 1
0.0365 1 1
0.0336 0.3083 1
0.0246 1 1
0.0325 1 1
0.2773 1 1
0.0202 1 1
0.0419 1 1
0.0053 0.5 0.5
0.0673 1 1
0.0976 1 1
0.0547 1 1
0.0053 0.5 0.5
0.1212 1 1
0.0594 1 1
0.0493 0.5 0.5
0.011 0.9096 1
0.1852 1 1
0.0507 0.3722 1
0.2278 1 1
0.0358 1 0.5
0.0571 1 0.5
0.0507 0.3722 1
0.082 1 1
0.0055 0.6531 0.9034
0.1334 1 1
0.0533 0.5 0.5
0.0268 1 1
0.005 0.8682 0.773
0.0363 0.7799 1
0.0589 1 0.5
0.2162 1 1
0.005 0.8682 0.773
0.0604 1 0.5
0.0153 0.5 0.5
0.0367 1 1
0.0448 1 0.5
0.2148 0.5 0.5
0.0273 0.3193 1
0.364019 1 1
0.0099 0.3091 0.5
0.0105 0.9522 0.5
0.0053 0.5 0.5
0.0766 1 1
0.0053 0.5 0.5
0.0088 1 1
0.0192 0.6183 1
0.0198 1 1
0.0052 0.8012 0
0.0269 0.7447 1
0.1257 1 1
0.0528 0.374 0.5
0.011 0.9096 1
0.0353 0.3279 1
0.0594 0.4913 1
0.2288 1 1
0.0053 0.5 0.5
0.0134 0.4508 1
0.0056 0.3935 0.882
0.038 0.5 0.5
0.1141 0.5 0.5
0.1222 1 1
0.0174 0.353 1
0.0265 0.4219 1
0.009 0.4492 0.5526
0.1782 1 1
0.221 1 1
0.0047 0.7744 1
0.2097 1 1
0.0528 0.374 0.5
0.0089 0.4921 1
0.0174 0.353 1
0.2185 1 1
0.0267 1 1
0.0222 0.5 0.5
0.2773 1 1
0.2373 1 1
0.205 0.5322 1
0.1007 1 1
0.0365 0.3838 1
0.054 1 1
0.0049 0.8012 0
0.0418 1 1
0.0553 0.9343 1
0.0673 1 1
0.0091 1 1
0.005 1 0.5
0.0053 1 1
0.0951 0.5246 1
0.0526 0.3055 0.5
0.022 0.2722 1
0.0053 0.5 0.5
0.009 1 0.5
0.0189 0.4605 1
0.0378 1 1
0.0468 1 1
0.0411 0.5581 1
0.0053 0.5 0.5
0.2198 0.5 0.5
0.1334 1 1
0.1671 1 1
0.062 0.5 0.5
0.0411 0.5581 1
0.032 0.5 0.5
0.0136 1 1
0.179 1 1
0.0097 1 0.5
0.0229 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.509693.50 (Trypanosoma cruzi), metallo-peptidase, Clan MG, Family M24
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