Detailed view for Rv1599

Basic information

TDR Targets ID: 6215
Mycobacterium tuberculosis, Probable histidinol dehydrogenase HisD (HDH)

Source Database / ID: Tuberculist / Rv1599 

pI: 4.6346 | Length (AA): 439 | MW (Da): 45346 | Number of Paralogs: 0

EC number(s): 1.1.1.23 | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0051287   NAD binding  
GO:0016491   oxidoreductase activity  
GO:0008270   zinc ion binding  
GO:0004399   histidinol dehydrogenase activity  

Process: (mouse over links to read term descriptions)

GO:0008152   metabolic process  
GO:0000105   histidine biosynthetic process  
Metabolic Pathways

Histidine metabolism (KEGG)
Global map (KEGG)

Functional classes

No functional classes assigned to this gene.

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the upper 60-80% group of genes.
Shows this level of upregulation in: Dormant phase.

Upregulation ranking: this gene ranks in the mid 40-60% group of genes.
Shows this level of upregulation in: Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 19
Cumulative epitope score: 21.3
Normalized epitope score: 4.9
Percentile: 55.5 (this protein belongs to the top 44.5% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_12571
Number of Paralogs: 0

Ortholog group members from selected species:
Arabidopsis thaliana NP_851260   ATHDH (HISTIDINOL DEHYDROGENASE); histidinol dehydrogenase ... |   OrthoMCL
Arabidopsis thaliana NP_568981   ATHDH (HISTIDINOL DEHYDROGENASE); histidinol dehydrogenase ... |   OrthoMCL
Cryptosporidium neoformas XP_570519   histidinol dehydrogenase ... |   OrthoMCL
Escherichia coli K12 NP_416524.1   histidinol dehydrogenase [Escherichia coli K12]... |   OrthoMCL
Mycobacterium leprae strain TN ML1257   Probable histidinol dehydrogenase HisD (HDH)... |   OrthoMCL
Mycobacterium tuberculosis Rv1599 (this record).   Probable histidinol dehydrogenase HisD (HDH)... |   OrthoMCL
Oryza sativa NP_001042506   Os01g0232700 ... |   OrthoMCL
Saccharomyces cerevisiae YCL030C   HIS4 SGDID:S000000535, Chr III from 68333-65934, reverse com... |   OrthoMCL

Essentiality Rv1599 has essentiality data
Gene/Ortholog: mtu1627 (OG4_12571); Phenotype: essential; Source study: nmpdr
Gene/Ortholog: eco1959 (OG4_12571); Phenotype: non-essential; Source study: blattner
Gene/Ortholog: eco1959 (OG4_12571); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco1959 (OG4_12571); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco1959 (OG4_12571); Phenotype: non-essential; Source study: shigen

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

  • Curated from literature

    No chemical compounds associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • From ChEMBL

      ChEMBL Species Known druggable target Reference Linked compounds
      Brassica oleracea var. capitata Histidinol dehydrogenase Show papers show compounds
      No orthologous druggable targets
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    3 literature references were collected for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

    No user comments are available for this gene.

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