Detailed information for compound 39775

Basic information

Technical information
  • TDR Targets ID: 39775
  • Name: (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbu tanoyl]amino]-4-methylpentanoic acid
  • MW: 308.373 | Formula: C16H24N2O4
  • H donors: 4 H acceptors: 4 LogP: -0.96 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H](C(=O)N[C@H](C(=O)O)CC(C)C)[C@@H](Cc1ccccc1)N
  • InChi: 1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
  • InChiKey: VGGGPCQERPFHOB-RDBSUJKOSA-N  


Substructure search Similarity search

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Synonyms

  • (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenyl-butanoyl]amino]-4-methyl-pentanoic acid
  • (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-1-oxo-4-phenylbutyl]amino]-4-methylpentanoic acid
  • (2S)-2-[[(2S,3R)-3-azanyl-2-hydroxy-4-phenyl-butanoyl]amino]-4-methyl-pentanoic acid
  • (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenyl-butanoyl]amino]-4-methyl-valeric acid
  • (2S)-2-[[(2S,3R)-3-azaniumyl-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoate
  • (2S)-2-[[(2S,3R)-3-azaniumyl-2-hydroxy-4-phenyl-butanoyl]amino]-4-methyl-pentanoate
  • (2S)-2-[[(2S,3R)-3-ammonio-2-hydroxy-1-oxo-4-phenylbutyl]amino]-4-methylpentanoate
  • (2S)-2-[[(2S,3R)-3-ammonio-2-hydroxy-4-phenyl-butanoyl]amino]-4-methyl-valerate
  • bestatin
  • SMR000059165
  • KBioGR_000273
  • KBioSS_000273
  • Bio2_000753
  • (2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl-L-leucine
  • AIDS-002934
  • AIDS002934
  • NK-421
  • BSPBio_001553
  • KBio2_002841
  • KBio2_005409
  • NCGC00025323-01
  • Tocris-1956
  • SMP1_000030
  • KBio3_000545
  • KBio3_000546
  • ST5405897
  • NCGC00025323-03
  • BCBcMAP01_000178
  • Ubestatin
  • KBio2_000273
  • ([2S,3R]-3-Amino-2-hydroxy-4-phenylbutanoyl)-L-leucine
  • 482609_ALDRICH
  • N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine
  • 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID
  • MLS000028649
  • IDI1_034023
  • (-)-N-((2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl)-L-leucine
  • (3-Amino-2-hydroxy-4-phenylbutanoyl)-L-leucine
  • (S-(R*,S*))-N-(3-Amino-2-hydroxy-4-phenylbutyroyl)-L-leucine
  • 3-(R)-Amino-2-(S)-hydroxy-4-phenylbutanoyl-(S)-leucine
  • BRN 4704312
  • EINECS 261-529-2
  • L-Leucine, N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-, (S-(R*,S*))-
  • NK 421
  • NSC 265489
  • Ubenimex [INN:JAN]
  • Ubenimexum [Latin]
  • Bio2_000273
  • Lopac0_000214
  • ZINC01542895

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum M17 leucyl aminopeptidase Curated by TDR Targets References
Mus musculus plasminogen activator, urokinase No references
Homo sapiens leucine aminopeptidase 3 Starlite/ChEMBL References
Leishmania major pyroglutamyl-peptidase I (C15 family) Curated by TDR Targets References
Rattus norvegicus Cystinyl aminopeptidase Starlite/ChEMBL References
Sus scrofa Aminopeptidase N Starlite/ChEMBL References
Vibrio proteolyticus Bacterial leucyl aminopeptidase Starlite/ChEMBL References
Rattus norvegicus Oligopeptide transporter, kidney isoform Starlite/ChEMBL References
Rattus norvegicus Aminopeptidase B Starlite/ChEMBL References
Plasmodium falciparum M1-family alanyl aminopeptidase Curated by TDR Targets References
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase No references
Mus musculus arginyl aminopeptidase (aminopeptidase B) Starlite/ChEMBL No references
Plasmodium falciparum FcB1/Columbia Zinc aminopeptidase Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Starlite/ChEMBL References
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Starlite/ChEMBL No references
Homo sapiens leukotriene A4 hydrolase Starlite/ChEMBL References
Mus musculus alanyl (membrane) aminopeptidase Starlite/ChEMBL References
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL No references
Homo sapiens arylsulfatase A Starlite/ChEMBL No references
Bos taurus Cytosol aminopeptidase Starlite/ChEMBL References
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 Curated by TDR Targets References
Homo sapiens adrenoceptor beta 2, surface Starlite/ChEMBL No references
Mus musculus plasminogen No references
Homo sapiens alanyl (membrane) aminopeptidase Starlite/ChEMBL References
Rattus norvegicus Aminopeptidase N Starlite/ChEMBL References
Mus musculus plasminogen activator, urokinase receptor No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) peptidase family M1 containing protein Get druggable targets OG5_127217 All targets in OG5_127217
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 Get druggable targets OG5_127293 All targets in OG5_127293
Onchocerca volvulus Get druggable targets OG5_127217 All targets in OG5_127217
Echinococcus granulosus 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium falciparum M17 leucyl aminopeptidase Get druggable targets OG5_127293 All targets in OG5_127293
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 Get druggable targets OG5_127293 All targets in OG5_127293
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) Get druggable targets OG5_129538 All targets in OG5_129538
Plasmodium berghei M17 leucyl aminopeptidase, putative Get druggable targets OG5_127293 All targets in OG5_127293
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania donovani cytosolic leucyl aminopeptidase Get druggable targets OG5_127293 All targets in OG5_127293
Echinococcus multilocularis leukotriene A 4 hydrolase Get druggable targets OG5_129538 All targets in OG5_129538
Mycobacterium leprae Probable cytosol aminopeptidase PepB Get druggable targets OG5_127293 All targets in OG5_127293
Echinococcus granulosus leucine aminopeptidase protein Get druggable targets OG5_127293 All targets in OG5_127293
Neospora caninum hypothetical protein Get druggable targets OG5_130542 All targets in OG5_130542
Candida albicans hypothetical protein Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans similar to bacterial leucyl aminopeptidase Get druggable targets OG5_133339 All targets in OG5_133339
Candida albicans leukotriene A4 hydrolase/leucyl aminopeptidase Get druggable targets OG5_129538 All targets in OG5_129538
Trypanosoma congolense ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Cryptosporidium hominis aminopeptidase N Get druggable targets OG5_130542 All targets in OG5_130542
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase Get druggable targets OG5_127293 All targets in OG5_127293
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans second version of peptide transport protein more similar to S. cerevisiae PTR2 Get druggable targets OG5_126717 All targets in OG5_126717
Leishmania braziliensis ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium yoelii m1-family aminopeptidase Get druggable targets OG5_130542 All targets in OG5_130542
Trypanosoma cruzi Cysteine peptidase, Clan CF, family C15 Get druggable targets OG5_150045 All targets in OG5_150045
Candida albicans leukotriene A4 hydrolase/leucyl aminopeptidase Get druggable targets OG5_129538 All targets in OG5_129538
Echinococcus granulosus leukotriene A 4 hydrolase Get druggable targets OG5_129538 All targets in OG5_129538
Brugia malayi Peptidase family M1 containing protein Get druggable targets OG5_127217 All targets in OG5_127217
Neospora caninum Aminopeptidase N (EC 3.4.11.2), related Get druggable targets OG5_130542 All targets in OG5_130542
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana 6-phospho-1-fructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127217 All targets in OG5_127217
Schistosoma japonicum ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans second version of peptide transport protein more similar to S. cerevisiae PTR2 Get druggable targets OG5_126717 All targets in OG5_126717
Theileria parva alpha-aminoacylpeptide hydrolase, putative Get druggable targets OG5_130542 All targets in OG5_130542
Leishmania braziliensis pyroglutamyl-peptidase I (PGP), putative Get druggable targets OG5_150045 All targets in OG5_150045
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative Get druggable targets OG5_127293 All targets in OG5_127293
Toxoplasma gondii leucyl aminopeptidase LAP Get druggable targets OG5_127293 All targets in OG5_127293
Leishmania major pyroglutamyl-peptidase I (C15 family) Get druggable targets OG5_150045 All targets in OG5_150045
Echinococcus granulosus aminopeptidase N Get druggable targets OG5_127217 All targets in OG5_127217
Loa Loa (eye worm) POT family protein Get druggable targets OG5_126717 All targets in OG5_126717
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Chlamydia trachomatis cytosol aminopeptidase Get druggable targets OG5_127293 All targets in OG5_127293
Echinococcus multilocularis leucine aminopeptidase protein Get druggable targets OG5_127293 All targets in OG5_127293
Leishmania infantum pyroglutamyl-peptidase I (PGP), putative Get druggable targets OG5_150045 All targets in OG5_150045
Plasmodium knowlesi M17 leucyl aminopeptidase, putative Get druggable targets OG5_127293 All targets in OG5_127293
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis aminopeptidase N Get druggable targets OG5_127217 All targets in OG5_127217
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130847 All targets in OG5_130847
Toxoplasma gondii aminopeptidase n, putative Get druggable targets OG5_130542 All targets in OG5_130542
Plasmodium berghei M1-family alanyl aminopeptidase, putative Get druggable targets OG5_130542 All targets in OG5_130542
Brugia malayi POT family protein Get druggable targets OG5_126717 All targets in OG5_126717
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense metallo-peptidase, Clan MF, Family M17, putative Get druggable targets OG5_127293 All targets in OG5_127293
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania donovani pyroglutamyl-peptidase I, putative Get druggable targets OG5_150045 All targets in OG5_150045
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma cruzi pyroglutamyl-peptidase I, putative Get druggable targets OG5_150045 All targets in OG5_150045
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative Get druggable targets OG5_129538 All targets in OG5_129538
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium knowlesi M1-family alanyl aminopeptidase, putative Get druggable targets OG5_130542 All targets in OG5_130542
Leishmania braziliensis cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 Get druggable targets OG5_127293 All targets in OG5_127293
Babesia bovis leucine aminopeptidase, putative Get druggable targets OG5_127293 All targets in OG5_127293
Plasmodium vivax M17 leucyl aminopeptidase, putative Get druggable targets OG5_127293 All targets in OG5_127293
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium tuberculosis Probable aminopeptidase PepB Get druggable targets OG5_127293 All targets in OG5_127293
Theileria parva leucine aminopeptidase, putative Get druggable targets OG5_127293 All targets in OG5_127293
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 Get druggable targets OG5_127293 All targets in OG5_127293
Brugia malayi phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) leukotriene A4 hydrolase Get druggable targets OG5_129538 All targets in OG5_129538
Neospora caninum Probable cytosol aminopeptidase, related Get druggable targets OG5_127293 All targets in OG5_127293
Mycobacterium ulcerans 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei gambiense pyroglutamyl-peptidase I (PGP), putative,cysteine peptidase, Clan CF, family C15, putative Get druggable targets OG5_150045 All targets in OG5_150045
Toxoplasma gondii aminopeptidase N protein Get druggable targets OG5_130542 All targets in OG5_130542
Leishmania infantum ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium falciparum M1-family alanyl aminopeptidase Get druggable targets OG5_130542 All targets in OG5_130542
Mycobacterium ulcerans leucyl aminopeptidase Get druggable targets OG5_127293 All targets in OG5_127293
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania donovani ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 Get druggable targets OG5_127293 All targets in OG5_127293
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium parvum putative leucine aminopeptidase; of possible plant or bacterial origin Get druggable targets OG5_127293 All targets in OG5_127293
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Toxoplasma gondii aminopeptidase N, putative Get druggable targets OG5_130542 All targets in OG5_130542
Schistosoma japonicum ko:K01256 membrane alanyl aminopeptidase [EC3.4.11.2], putative Get druggable targets OG5_127217 All targets in OG5_127217
Trypanosoma brucei gambiense cytosolic leucyl aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17, putative Get druggable targets OG5_127293 All targets in OG5_127293
Trypanosoma brucei pyroglutamyl-peptidase I, putative Get druggable targets OG5_150045 All targets in OG5_150045
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127217 All targets in OG5_127217
Plasmodium yoelii putative leucine aminopeptidase Get druggable targets OG5_127293 All targets in OG5_127293
Plasmodium vivax M1-family alanyl aminopeptidase, putative Get druggable targets OG5_130542 All targets in OG5_130542
Leishmania mexicana pyroglutamyl-peptidase I (PGP), putative,cysteine peptidase, Clan CF, family C15, putative Get druggable targets OG5_150045 All targets in OG5_150045
Babesia bovis aminopeptidase, putative Get druggable targets OG5_130542 All targets in OG5_130542
Cryptosporidium parvum zincin/aminopeptidase N like metalloprotease Get druggable targets OG5_130542 All targets in OG5_130542
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium hominis leucine aminopeptidase Get druggable targets OG5_127293 All targets in OG5_127293
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative Get druggable targets OG5_127293 All targets in OG5_127293
Candida albicans similar to bacterial leucyl aminopeptidase Get druggable targets OG5_133339 All targets in OG5_133339
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis puromycin sensitive aminopeptidase Aminopeptidase N   963 aa 981 aa 29.2 %
Mycobacterium ulcerans arylsulfatase AtsD arylsulfatase A 509 aa 439 aa 25.1 %
Echinococcus granulosus puromycin sensitive aminopeptidase alanyl (membrane) aminopeptidase 967 aa 976 aa 28.8 %
Echinococcus multilocularis puromycin sensitive aminopeptidase Aminopeptidase N   963 aa 981 aa 28.8 %
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 arginyl aminopeptidase (aminopeptidase B) 611 aa 512 aa 22.9 %
Echinococcus granulosus Mastin plasminogen activator, urokinase 433 aa 358 aa 24.9 %
Onchocerca volvulus Aminopeptidase N   963 aa 893 aa 32.0 %
Brugia malayi Peptidase family M1 containing protein Cystinyl aminopeptidase   1025 aa 906 aa 30.4 %
Echinococcus granulosus puromycin sensitive aminopeptidase Aminopeptidase N   963 aa 975 aa 29.1 %
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 leucine aminopeptidase 3 519 aa 428 aa 28.5 %
Echinococcus granulosus puromycin sensitive aminopeptidase alanyl (membrane) aminopeptidase 966 aa 979 aa 27.5 %
Echinococcus multilocularis puromycin sensitive aminopeptidase Aminopeptidase N   963 aa 988 aa 28.5 %
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 leukotriene A4 hydrolase 611 aa 508 aa 22.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0024 0.0005 0.0005
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0081 0.2569
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0057 0.0028 0.0182
Schistosoma mansoni neuropeptide F-like receptor 0.1211 0.085 0.0973
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.001 0.0169
Onchocerca volvulus 0.0031 0.001 0.0063
Echinococcus multilocularis cytosolic carboxypeptidase protein 5 0.0076 0.0042 0.0267
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0031 0.001 0.0216
Onchocerca volvulus 0.0031 0.001 0.0063
Schistosoma mansoni nAChR subunit 0.0846 0.0589 0.0675
Brugia malayi Integrin beta pat-3 precursor 0.0203 0.0132 0.0853
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0083 0.0047 0.0054
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1211 0.085 0.0973
Trypanosoma cruzi glucose transporter, putative 0.0031 0.001 0.0119
Onchocerca volvulus 0.1211 0.085 0.5478
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0001 0.0005
Echinococcus granulosus integrin beta 2 0.015 0.0095 0.0611
Schistosoma mansoni flap endonuclease-1 0.0028 0.0008 0.0009
Brugia malayi ecdysteroid receptor 0.0019 0.0001 0.0006
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0394 0.0268 0.1727
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0023 0.0004 0.0039
Echinococcus multilocularis glycine receptor subunit beta 0.0846 0.0589 0.3799
Echinococcus granulosus leucyl aminopeptidase 0.0085 0.0048 0.0309
Loa Loa (eye worm) hypothetical protein 0.0365 0.0248 0.1596
Echinococcus granulosus beta-adrenergic receptor kinase 0.0018 0.0001 0.0003
Mycobacterium ulcerans potassium/proton antiporter 0.005 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.0276 0.0184 0.1188
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0078 0.0044 0.2154
Trypanosoma brucei histone deacetylase, putative 0.0071 0.0038 0.0506
Echinococcus granulosus histone deacetylase 3 0.0078 0.0044 0.028
Echinococcus granulosus atrial natriuretic peptide receptor 0.0021 0.0003 0.0017
Trichomonas vaginalis myo-inositol transporter, putative 0.0031 0.001 0.0477
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.005 0.0024 0.0152
Brugia malayi A-kinase anchor protein 10, precursor 0.0017 0 0.0001
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0862 0.0601 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.0149 0.0961
Echinococcus granulosus glycine receptor subunit alpha 1 0.0846 0.0589 0.3799
Schistosoma mansoni histone deacetylase 4 5 0.0071 0.0038 0.0043
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.022 0.0144 0.0929
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0038 0.0512
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0001 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.014 0.0087 0.4309
Echinococcus multilocularis sodium:hydrogen exchanger 0.0264 0.0175 0.113
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.022 0.0144 0.0929
Loa Loa (eye worm) hypothetical protein 0.0044 0.0019 0.0123
Trypanosoma brucei PAB1-binding protein , putative 0.0037 0.0014 0.0179
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1211 0.085 0.5478
Loa Loa (eye worm) hypothetical protein 0.0846 0.0589 0.3799
Onchocerca volvulus 0.1211 0.085 0.5478
Schistosoma mansoni biogenic amine receptor 0.1211 0.085 0.0973
Toxoplasma gondii LsmAD domain-containing protein 0.0037 0.0014 0.0233
Schistosoma mansoni neurotransmitter gated ion channel 0.0461 0.0316 0.0361
Schistosoma mansoni myosin xvIII 0.1211 0.085 0.0973
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0024 0.0005 0.0053
Echinococcus granulosus tyrosine kinase 0.0023 0.0004 0.0028
Toxoplasma gondii histone deacetylase HDAC1 0.0071 0.0038 0.0633
Brugia malayi Thioredoxin reductase 0.0069 0.0037 0.0238
Trypanosoma cruzi hexose transporter, putative 0.0031 0.001 0.0119
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.005 0.0024 0.0306
Loa Loa (eye worm) hypothetical protein 0.0846 0.0589 0.3799
Trichomonas vaginalis glucosylceramidase, putative 0.014 0.0087 0.4309
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0385 0.0262 0.1686
Plasmodium falciparum histone deacetylase 2 0.0071 0.0038 0.0616
Schistosoma mansoni hypothetical protein 0.0328 0.0221 0.0253
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0076 0.0042 0.0692
Trichomonas vaginalis mercuric reductase, putative 0.0024 0.0005 0.023
Trypanosoma brucei Enriched in surface-labeled proteome protein 12 0.01 0.0059 0.079
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0026 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0037 0.0014 0.009
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0019 0.0001 0.0006
Echinococcus granulosus histone deacetylase 8 0.0034 0.0012 0.0075
Loa Loa (eye worm) glutamate receptor 2 0.016 0.0102 0.0655
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0373 0.0253 0.1631
Loa Loa (eye worm) NHE-3 0.0264 0.0175 0.113
Trypanosoma cruzi zinc carboxypeptidase, putative 0.0076 0.0042 0.0552
Brugia malayi RE15519p 0.1211 0.085 0.5476
Schistosoma mansoni integrin alpha-ps 0.0023 0.0004 0.0005
Trypanosoma brucei THT1 - hexose transporter, putative 0.0068 0.0036 0.0482
Brugia malayi histone deacetylase 3 (HD3) 0.0078 0.0044 0.0281
Onchocerca volvulus 0.0441 0.0301 0.1944
Plasmodium falciparum plasmepsin III 0.0023 0.0004 0.0045
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0018
Echinococcus multilocularis neuropeptide receptor A26 0.158 0.1112 0.7167
Plasmodium falciparum plasmepsin VII 0.0023 0.0004 0.0045
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0144 0.0091 0.1491
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0076 0.0042 0.2056
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.0038 0.0248
Loa Loa (eye worm) TK/EGFR protein kinase 0.0144 0.009 0.0581
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.0038 0.0509
Brugia malayi Protein kinase domain containing protein 0.0064 0.0034 0.0217
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0001 0.0005
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Echinococcus multilocularis General substrate transporter 0.0189 0.0122 0.0787
Toxoplasma gondii aspartyl protease ASP1 0.0057 0.0028 0.0473
Echinococcus multilocularis glutamate receptor 2 0.0181 0.0117 0.0751
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0461 0.0316 0.0361
Onchocerca volvulus 0.0019 0.0001 0.0007
Entamoeba histolytica sodium/proton antiporter, putative 0.005 0.0024 0.0742
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0846 0.0589 0.3799
Onchocerca volvulus 0.0076 0.0042 0.0268
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0024 0.0005 0.0051
Entamoeba histolytica hypothetical protein 0.0043 0.0019 0.0588
Trichomonas vaginalis glucose transporter, putative 0.0068 0.0036 0.1792
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0037 0.0014 0.0014
Schistosoma mansoni opsin-like receptor 0.1211 0.085 0.0973
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.022 0.0144 0.0929
Trichomonas vaginalis glucose transporter, putative 0.0068 0.0036 0.1792
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0019 0.0001 0.0006
Toxoplasma gondii histone deacetylase HDAC4 0.0034 0.0012 0.0196
Echinococcus multilocularis G protein coupled receptor 139 0.1211 0.085 0.5478
Onchocerca volvulus 0.0031 0.001 0.0063
Echinococcus multilocularis expressed conserved protein 0.0051 0.0024 0.0153
Schistosoma mansoni myelin transcription factor 1 myt1 0.0075 0.0041 0.0047
Echinococcus granulosus sodium:hydrogen exchanger 2 (nhe2) 0.0213 0.014 0.0899
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0846 0.0589 0.3799
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0013 0.0637
Brugia malayi aspartic protease BmAsp-1, identical 0.0023 0.0004 0.0024
Loa Loa (eye worm) hypothetical protein 0.0846 0.0589 0.3799
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.001 0.0063
Loa Loa (eye worm) ACC-1 protein 0.0846 0.0589 0.3799
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0846 0.0589 0.3799
Loa Loa (eye worm) hypothetical protein 0.0023 0.0004 0.0025
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0665 0.0461 0.0527
Loa Loa (eye worm) histone deacetylase 0.0071 0.0038 0.0245
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0047 0.0021 0.0136
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0012 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0001 0.0006
Brugia malayi Zinc carboxypeptidase family protein 0.0076 0.0042 0.0268
Trichomonas vaginalis glutathione reductase, putative 0.0024 0.0005 0.023
Trypanosoma brucei pyroglutamyl-peptidase I, putative 0.0519 0.0357 0.4846
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0461 0.0316 0.2033
Echinococcus multilocularis epidermal growth factor receptor 0.0078 0.0043 0.0278
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0001 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0001 0.0006
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0373 0.0253 0.029
Echinococcus granulosus neuropeptide receptor 0.1211 0.085 0.5478
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0024 0.0005 0.0062
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0021 0.0003 0.0017
Echinococcus granulosus o acyltransferase membrane bound domain 0.0019 0.0001 0.0006
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.001 0.0496
Loa Loa (eye worm) hypothetical protein 0.0846 0.0589 0.3799
Echinococcus granulosus SAM and MBT domain containing protein 0.0066 0.0035 0.0222
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0144 0.0091 0.1218
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Trichomonas vaginalis alpha-glucosidase, putative 0.0024 0.0005 0.0232
Toxoplasma gondii aminopeptidase n, putative 0.0862 0.0601 1
Echinococcus granulosus glutamate receptor subunit protein glur 0.0066 0.0035 0.0224
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0213 0.0139 0.0897
Schistosoma mansoni sugar transporter 0.0031 0.001 0.0011
Brugia malayi nuclear hormone receptor 0.0019 0.0001 0.0006
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.1211 0.085 0.0973
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Echinococcus multilocularis epidermal growth factor receptor 0.0144 0.009 0.058
Loa Loa (eye worm) hypothetical protein 0.0076 0.0042 0.0268
Loa Loa (eye worm) hypothetical protein 0.0385 0.0262 0.1686
Echinococcus multilocularis lysine specific demethylase 5A 0.0085 0.0048 0.0311
Echinococcus granulosus histone deacetylase 7 0.0071 0.0038 0.0244
Trypanosoma brucei N-myristoyl transferase, putative 0.0043 0.0019 0.0241
Plasmodium vivax glutathione reductase, putative 0.0069 0.0037 0.0596
Schistosoma mansoni sex comb on midleg homolog 0.0066 0.0035 0.0039
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.006 0.003 0.003
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0846 0.0589 0.3799
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0076 0.0042 0.2056
Leishmania major N-myristoyl transferase, putative 0.0043 0.0019 0.0238
Brugia malayi Sodium/hydrogen exchanger 8 0.005 0.0024 0.0152
Trichomonas vaginalis glucosylceramidase, putative 0.014 0.0087 0.4309
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0013 0.0199
Entamoeba histolytica histone deacetylase, putative 0.0078 0.0044 0.1378
Echinococcus multilocularis neuropeptide receptor 0.1211 0.085 0.5478
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0127 0.0078 0.0078
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0157 0.01 0.0099
Trypanosoma cruzi histone deacetylase, putative 0.0034 0.0012 0.0146
Onchocerca volvulus 0.0043 0.0019 0.012
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.001 0.0063
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0001 0.0006
Brugia malayi hypothetical protein 0.0031 0.001 0.0063
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Schistosoma mansoni DNA polymerase eta 0.003 0.0009 0.001
Leishmania major hypothetical protein, conserved 0.0037 0.0014 0.0176
Echinococcus granulosus g protein coupled receptor 0.1211 0.085 0.5478
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0037 0.0014 0.023
Loa Loa (eye worm) hypothetical protein 0.0846 0.0589 0.3799
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1211 0.085 0.5478
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0008 0.0049
Loa Loa (eye worm) hypothetical protein 0.0055 0.0027 0.0172
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0007
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0051 0.0024 0.0154
Schistosoma mansoni neuropeptide F-like receptor 0.1211 0.085 0.0973
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0373 0.0253 0.1631
Echinococcus granulosus peptide allatostatin:somatostatin 0.1211 0.085 0.5478
Mycobacterium ulcerans polyketide synthase 0.006 0.003 0.003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0206 0.0135 0.6668
Schistosoma mansoni hypothetical protein 0.0021 0.0003 0.0003
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0846 0.0589 0.3799
Echinococcus granulosus muscleblind protein 0.0276 0.0184 0.1187
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.1211 0.085 0.5476
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0281 0.0188 0.121
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0019 0.0001 0.0001
Echinococcus granulosus expressed protein 0.0339 0.0229 0.1474
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0063
Plasmodium falciparum thioredoxin reductase 0.0069 0.0037 0.0596
Brugia malayi Kelch motif family protein 0.0031 0.001 0.0063
Brugia malayi hypothetical protein 0.0043 0.0019 0.012
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0425 0.029 0.3933
Mycobacterium ulcerans membrane transporter 0.005 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.0328 0.0221 0.1424
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.1211 0.085 0.5476
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0074 0.0041 0.0261
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0007 0.0043
Trypanosoma cruzi histone deacetylase, putative 0.0071 0.0038 0.0503
Toxoplasma gondii zinc carboxypeptidase, putative 0.0076 0.0042 0.0692
Brugia malayi regulator of G-protein signaling egl-10 0.0017 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0059 0.003 0.019
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0181 0.0117 0.0751
Onchocerca volvulus Putative transporter 0.0031 0.001 0.0063
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0665 0.0461 0.297
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0373 0.0253 0.4209
Brugia malayi G protein-coupled receptor 0.1211 0.085 0.5476
Brugia malayi Histone deacetylase family protein 0.0071 0.0038 0.0245
Trichomonas vaginalis glucose transporter, putative 0.0031 0.001 0.0477
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0001 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0013 0.0637
Loa Loa (eye worm) hypothetical protein 0.0034 0.0012 0.0076
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0063
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0127 0.0078 0.0078
Brugia malayi jmjC domain containing protein 0.0023 0.0004 0.0025
Plasmodium falciparum glutathione reductase 0.0069 0.0037 0.0596
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.0013 0.0637
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0461 0.0316 0.0361
Echinococcus multilocularis leucine aminopeptidase protein 0.0541 0.0373 0.2405
Giardia lamblia Histone deacetylase 0.0078 0.0044 0.2276
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0373 0.0253 0.1631
Schistosoma mansoni Slc9a7 protein 0.005 0.0024 0.0027
Trichomonas vaginalis N-myristoyl transferase, putative 0.0028 0.0008 0.0389
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0019 0.0001 0.0006
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0127 0.0078 0.0078
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0024 0.0005 0.0232
Echinococcus granulosus dro:myosuppressin receptor 0.1211 0.085 0.5478
Echinococcus multilocularis neuropeptide Y receptor 0.1211 0.085 0.5478
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0019
Toxoplasma gondii hypothetical protein 0.0373 0.0253 0.4209
Schistosoma mansoni hypothetical protein 0.0022 0.0004 0.0004
Trichomonas vaginalis glutaminase, putative 0.0301 0.0202 1
Plasmodium vivax aspartyl proteinase, putative 0.0057 0.0028 0.0456
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0001 0.0001
Trichomonas vaginalis sugar transport protein, putative 0.0031 0.001 0.0477
Trypanosoma brucei THT1 - hexose transporter, putative 0.0068 0.0036 0.0482
Schistosoma mansoni nAChR subunit 0.0846 0.0589 0.0675
Brugia malayi hypothetical protein 0.0031 0.001 0.0063
Loa Loa (eye worm) jmjC domain-containing protein 0.0023 0.0004 0.0025
Loa Loa (eye worm) hypothetical protein 0.0076 0.0042 0.0268
Giardia lamblia Sodium/hydrogen exchanger 3 0.0264 0.0175 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0023 0.0004 0.0028
Trichomonas vaginalis transmembrane protein nessy, putative 0.0019 0.0001 0.0045
Brugia malayi hypothetical protein 0.0385 0.0262 0.1686
Loa Loa (eye worm) histone deacetylase 1 0.0078 0.0044 0.0281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1211 0.085 0.0973
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0024 0.0005 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.1211 0.085 0.5478
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0373 0.0253 0.029
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0001 0.0006
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.0038 0.1215
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Loa Loa (eye worm) hypothetical protein 0.015 0.0094 0.0609
Brugia malayi Regulator of G protein signaling domain containing protein 0.0017 0 0.0001
Trypanosoma cruzi N-myristoyl transferase, putative 0.0043 0.0019 0.0238
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.005 0.0024 0.0152
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.0025 0.0162
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0077 0.0042 0.0271
Trichomonas vaginalis glucosylceramidase, putative 0.014 0.0087 0.4309
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.0043 0.0019 0.0119
Trypanosoma cruzi hexose transporter, putative 0.0068 0.0036 0.048
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Echinococcus granulosus somatostatin receptor 0.1211 0.085 0.5478
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0846 0.0589 0.3799
Toxoplasma gondii Na+/H+ exchanger NHE1 0.005 0.0024 0.0391
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0035 0.0227
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.001 0.0124
Trypanosoma brucei glucose transporter 1E 0.0068 0.0036 0.0482
Brugia malayi putative neuropeptide receptor 0.1211 0.085 0.5476
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0281 0.0188 0.2541
Treponema pallidum fructose-bisphosphate aldolase 0.0206 0.0135 0.0862
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0385 0.0262 0.1686
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0373 0.0253 0.4209
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0063
Brugia malayi metabotropic glutamate receptor type 2 0.0021 0.0003 0.0018
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0181 0.0117 0.0751
Loa Loa (eye worm) hypothetical protein 0.0385 0.0262 0.1686
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0001 0.0005
Echinococcus multilocularis sodium and chloride dependent glycine 0.0373 0.0253 0.1631
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.001 0.0065
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.1211 0.085 0.0973
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Loa Loa (eye worm) N-myristoyltransferase 2 0.0043 0.0019 0.012
Onchocerca volvulus 0.0023 0.0004 0.0024
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0846 0.0589 0.0675
Loa Loa (eye worm) hhat protein 0.0019 0.0001 0.0007
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0117 0.0071 0.0071
Schistosoma mansoni histamine h1 receptor 0.1211 0.085 0.0973
Echinococcus multilocularis neuropeptide receptor 0.1211 0.085 0.5478
Trichomonas vaginalis porcupine, putative 0.0019 0.0001 0.0045
Toxoplasma gondii type I fatty acid synthase, putative 0.0061 0.0031 0.0515
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.2107 0.1487 0.9585
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.0038 0.0247
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0016 0.0205
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0107 0.0064 0.0412
Brugia malayi neuropeptide F receptor 0.1211 0.085 0.5476
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.0001
Mycobacterium ulcerans thioesterase 0.0047 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0063
Plasmodium falciparum ataxin-2 like protein, putative 0.0037 0.0014 0.0216
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0541 0.0373 0.6197
Echinococcus multilocularis solute carrier family 22 0.0031 0.001 0.0062
Echinococcus granulosus solute carrier family 22 0.0031 0.001 0.0062
Loa Loa (eye worm) hypothetical protein 0.0264 0.0175 0.113
Echinococcus granulosus g-protein coupled receptor 0.1211 0.085 0.5478
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.1211 0.085 0.5476
Mycobacterium ulcerans sugar transporter 0.0031 0.001 0.001
Onchocerca volvulus 0.1211 0.085 0.5478
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0085 0.0048 0.0309
Toxoplasma gondii histone lysine methyltransferase SET1 0.0087 0.005 0.0825
Schistosoma mansoni nAChR subunit 0.0385 0.0262 0.0299
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0085 0.0048 0.0309
Schistosoma mansoni nAChR subunit 0.0385 0.0262 0.0299
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0024 0.0005 0.003
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.001 0.0063
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0084 0.0048 0.0048
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0019 0.012
Brugia malayi hypothetical protein 0.1211 0.085 0.5476
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0056 0.0028 0.0028
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0019 0.0001 0.0006
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0085 0.0048 0.0639
Trypanosoma cruzi extracellular receptor, putative 0.0021 0.0003 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.1211 0.085 0.5478
Schistosoma mansoni hypothetical protein 0.003 0.0009 0.001
Echinococcus multilocularis beta adrenergic receptor kinase 0.0018 0.0001 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.014 0.0087 0.4309
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.003 0.0009 0.0273
Brugia malayi hypothetical protein 0.0373 0.0253 0.1631
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0024 0.0005 0.0005
Schistosoma mansoni neuropeptide receptor 0.1211 0.085 0.0973
Echinococcus multilocularis leucyl aminopeptidase 0.0085 0.0048 0.0309
Loa Loa (eye worm) hypothetical protein 0.0373 0.0253 0.1631
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0013 0.0216
Echinococcus multilocularis histone deacetylase 6 0.0073 0.0039 0.0254
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Mycobacterium tuberculosis Probable conserved integral membrane transport protein YjcE 0.005 0.0024 0.0023
Onchocerca volvulus 0.0021 0.0003 0.0018
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0056 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0144 0.0091 0.0584
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0083 0.0047 0.0303
Loa Loa (eye worm) integrin alpha pat-2 0.0153 0.0097 0.0622
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0127 0.0078 0.0078
Schistosoma mansoni metabotropic glutamate receptor 0.0021 0.0003 0.0003
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0018 0.0001 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0001 0.0045
Brugia malayi Sugar transporter family protein 0.022 0.0144 0.093
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.01 0.0059 0.0787
Echinococcus granulosus c-Jun N-terminal kinases 0.0104 0.0062 0.0397
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0094 0.0055 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0001 0.0006
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0037 0.0014 0.0014
Loa Loa (eye worm) aspartyl protease 6 0.0023 0.0004 0.0024
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0131 0.0081 0.0081
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0373 0.0253 0.029
Plasmodium vivax histone deacetylase 1, putative 0.0078 0.0044 0.0709
Loa Loa (eye worm) hypothetical protein 0.0373 0.0253 0.1631
Trypanosoma brucei hypothetical protein, conserved 0.01 0.0059 0.079
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0023 0.0004 0.0063
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0846 0.0589 0.3799
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0029 0.0008 0.0054
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0354 0.024 0.1544
Brugia malayi Tachykinin-like peptides receptor 99D 0.1211 0.085 0.5476
Mycobacterium ulcerans thioesterase TesA 0.0047 0.0021 0.0021
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0144 0.0091 0.1491
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0206 0.0135 0.6668
Echinococcus granulosus geminin 0.0051 0.0024 0.0155
Schistosoma mansoni sodium/chloride dependent transporter 0.0374 0.0254 0.029
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0019 0.0001 0.0006
Mycobacterium leprae PROBABLE HYDROLASE 0.0026 0.0006 0.0006
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0018 0.0001 0.0003
Brugia malayi jmjC domain containing protein 0.0023 0.0004 0.0025
Schistosoma mansoni sodium/hydrogen exchanger 3 (nhe3) 0.005 0.0024 0.0027
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.1211 0.085 0.5476
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0076 0.0042 0.2056
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0846 0.0589 0.0675
Plasmodium vivax plasmepsin IV, putative 0.0057 0.0028 0.0456
Brugia malayi hypothetical protein 0.0023 0.0004 0.0024
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0373 0.0253 0.029
Loa Loa (eye worm) cytochrome P450 0.0127 0.0078 0.0506
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0063
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0846 0.0589 0.3799
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.001 0.0477
Onchocerca volvulus 0.0846 0.0589 0.38
Onchocerca volvulus 0.005 0.0024 0.0152
Leishmania major cytochrome p450-like protein 0.0147 0.0092 0.124
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0441 0.0301 0.1943
Schistosoma mansoni sodium/chloride dependent transporter 0.2197 0.1551 0.1776
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0181 0.0117 0.0751
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0127 0.0078 0.0078
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0001 0.0006
Schistosoma mansoni sugar transporter 0.0031 0.001 0.0011
Schistosoma mansoni glutamate receptor kainate 0.016 0.0102 0.0116
Echinococcus granulosus neuropeptide receptor 0.1211 0.085 0.5478
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0373 0.0253 0.1631
Onchocerca volvulus 0.0066 0.0035 0.0223
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0081 0.1093
Brugia malayi Muscleblind-like protein 0.0276 0.0184 0.1188
Echinococcus multilocularis 0.0076 0.0042 0.0267
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.0081 0.0081
Toxoplasma gondii aldehyde dehydrogenase 0.0117 0.0071 0.118
Onchocerca volvulus 0.0031 0.001 0.0063
Loa Loa (eye worm) TK/INSR protein kinase 0.0047 0.0021 0.0137
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0005 0.0051
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0001 0.0009
Brugia malayi Glycosyl hydrolases family 31 protein 0.0024 0.0005 0.0031
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0029 0.0009 0.0142
Trichomonas vaginalis glucosylceramidase, putative 0.0147 0.0092 0.4574
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0001 0.0009
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0846 0.0589 0.3799
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.1211 0.085 0.5478
Brugia malayi hypothetical protein 0.0017 0 0.0001
Trypanosoma cruzi trypanothione reductase, putative 0.0069 0.0037 0.0487
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0024 0.0005 0.0079
Loa Loa (eye worm) hypothetical protein 0.0276 0.0184 0.1188
Trypanosoma brucei glucose transporter 2A 0.0068 0.0036 0.0482
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0047 0.0021 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0001 0.0006
Onchocerca volvulus 0.1211 0.085 0.5478
Plasmodium vivax histone deacetylase, putative 0.0071 0.0038 0.0616
Leishmania major histone deacetylase, putative 0.0071 0.0038 0.0503
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0127 0.0078 0.0078
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0001 0.0004
Plasmodium falciparum hexose transporter 0.022 0.0144 0.2385
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0018
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0083 0.0047 0.0304
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0846 0.0589 0.3799
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.001 0.0126
Loa Loa (eye worm) matrixin family protein 0.0047 0.0021 0.0135
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0206 0.0135 0.4265
Leishmania major pyroglutamyl-peptidase I (C15 family) 0.0519 0.0357 0.4844
Toxoplasma gondii cytochrome p450 superfamily protein 0.0127 0.0078 0.1305
Brugia malayi glutaminase DH11.1 0.0301 0.0202 0.1301
Onchocerca volvulus 0.0021 0.0003 0.0018
Brugia malayi ORL1-like opioid receptor 0.1211 0.085 0.5476
Mycobacterium ulcerans integral membrane transport protein 0.0031 0.001 0.001
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0147 0.0092 0.0092
Echinococcus granulosus tm gpcr rhodopsin 0.1211 0.085 0.5478
Onchocerca volvulus 0.0044 0.0019 0.0123
Schistosoma mansoni apoferritin-2 0.002 0.0002 0.0002
Trypanosoma cruzi sugar transporter, putative 0.0031 0.001 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.0208
Echinococcus granulosus Squalene phytoene synthase 0.0328 0.0221 0.1423
Echinococcus granulosus neuropeptide s receptor 0.158 0.1112 0.7167
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.0043 0.0019 0.0584
Wolbachia endosymbiont of Brugia malayi Kef-type K+ transport system, membrane component 0.005 0.0024 0.0587
Echinococcus multilocularis leucyl aminopeptidase 0.0085 0.0048 0.0309
Onchocerca volvulus 0.0846 0.0589 0.38
Schistosoma mansoni nAChR subunit 0.0846 0.0589 0.0675
Brugia malayi hypothetical protein 0.0281 0.0188 0.121
Brugia malayi PHD-finger family protein 0.0029 0.0009 0.0056
Echinococcus granulosus neuropeptide FF receptor 2 0.1211 0.085 0.5478
Schistosoma mansoni biogenic amine (5HT) receptor 0.1211 0.085 0.0973
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0846 0.0589 0.3799
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0001 0.0006
Echinococcus multilocularis jumonji domain containing 1A 0.0023 0.0004 0.0024
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.015 0.0095 0.0609
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0206 0.0135 0.4265
Schistosoma mansoni peptidase 0.0076 0.0042 0.0047
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0019 0.0001 0.0006
Brugia malayi hypothetical protein 0.0385 0.0261 0.1685
Loa Loa (eye worm) hypothetical protein 0.0461 0.0316 0.2033
Echinococcus granulosus leucine aminopeptidase protein 0.0541 0.0373 0.2405
Schistosoma mansoni ferritin 0.002 0.0002 0.0002
Brugia malayi Zinc carboxypeptidase family protein 0.0076 0.0042 0.0268
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0281 0.0188 0.93
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0461 0.0316 0.2033
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0037 0.0014 0.0092
Onchocerca volvulus 0.0184 0.0119 0.0767
Plasmodium vivax plasmepsin V, putative 0.0023 0.0004 0.0045
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14 0.0076 0.0042 0.0552
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.2197 0.1551 0.1776
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0062 0.0032 0.0514
Echinococcus granulosus Zinc carboxypeptidase family protein 0.0076 0.0042 0.0267
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0018 0.0001 0.0003
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0024 0.0005 0.0051
Schistosoma mansoni hypothetical protein 0.0019 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0001 0.0006
Echinococcus granulosus sodium:hydrogen exchanger 7 0.005 0.0024 0.0151
Onchocerca volvulus Glucosylceramidase homolog 0.014 0.0087 0.0561
Echinococcus granulosus hypothetical protein 0.1211 0.085 0.5478
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0081 0.2569
Loa Loa (eye worm) acetylcholine receptor protein 0.0385 0.0262 0.1686
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0024 0.0005 0.0148
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0373 0.0253 0.029
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Loa Loa (eye worm) hypothetical protein 0.0076 0.0042 0.0268
Plasmodium falciparum glutathione reductase 0.0024 0.0005 0.0062
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0665 0.0461 0.2971
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0135 0.0084 0.0542
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1211 0.085 0.0973
Schistosoma mansoni hypothetical protein 0.0327 0.0221 0.0252
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0067 0.0035 0.0228
Loa Loa (eye worm) cytochrome P450 family protein 0.0144 0.009 0.0581
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0018
Onchocerca volvulus 0.0076 0.0042 0.0268
Echinococcus granulosus receptor type guanylyl cyclase 0.0023 0.0004 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.0139 0.6889
Schistosoma mansoni jumonji/arid domain-containing protein 0.009 0.0052 0.0059
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0005 0.0051
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0038 0.0509
Schistosoma mansoni hypothetical protein 0.0051 0.0024 0.0028
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0081 0.4016
Loa Loa (eye worm) hypothetical protein 0.0076 0.0042 0.0268
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0846 0.0589 0.3799
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Echinococcus granulosus glycine receptor subunit beta 0.0846 0.0589 0.3799
Loa Loa (eye worm) jmjC domain-containing protein 0.009 0.0052 0.0332
Mycobacterium ulcerans aminopeptidase N PepN 0.0281 0.0188 0.0188
Schistosoma mansoni glucose transport protein 0.022 0.0144 0.0165
Trichomonas vaginalis sugar transporter, putative 0.0068 0.0036 0.1792
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0004 0.0004
Echinococcus granulosus thioredoxin glutathione reductase 0.0069 0.0037 0.0239
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1211 0.085 0.0973
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0006
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Onchocerca volvulus 0.1211 0.085 0.5478
Trypanosoma cruzi hexose transporter, putative 0.0068 0.0036 0.048
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0023 0.0004 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0001 0.0006
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0373 0.0253 0.1631
Toxoplasma gondii flagellar/basal body protein 0.0076 0.0042 0.0692
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0013 0.0223
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0048 0.0022 0.0143
Brugia malayi Serotonin receptor 0.1211 0.085 0.5476
Echinococcus granulosus expressed protein 0.002 0.0002 0.001
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0028 0.0008 0.0044
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0001 0.0005
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0281 0.0188 0.2541
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.001 0.0477
Schistosoma mansoni alpha-glucosidase 0.0093 0.0054 0.0062
Giardia lamblia Fructose-bisphosphate aldolase 0.0206 0.0135 0.7614
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0001 0.0009
Echinococcus granulosus lysosomal alpha glucosidase 0.0108 0.0065 0.0416
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0009 0.0461
Trypanosoma brucei glycerol uptake protein, putative 0.0019 0.0001 0.0003
Entamoeba histolytica hypothetical protein 0.0021 0.0003 0.0083
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0024 0.0005 0.0082
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0004 0.0004
Echinococcus granulosus mitochondrial sodium:hydrogen exchanger 9B2 0.005 0.0024 0.0151
Loa Loa (eye worm) hypothetical protein 0.0023 0.0004 0.0027
Loa Loa (eye worm) hypothetical protein 0.0184 0.0119 0.0766
Schistosoma mansoni zinc finger protein 0.0024 0.0005 0.0005
Onchocerca volvulus Histone deacetylase 10 homolog 0.0034 0.0012 0.0076
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0056 0.0028 0.0028
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0001 0.0005
Echinococcus granulosus fmrfamide receptor 0.1211 0.085 0.5478
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0127 0.0078 0.0078
Trypanosoma cruzi sodium/hydrogen exchanger, putative 0.005 0.0024 0.0306
Brugia malayi MBOAT family protein 0.0019 0.0001 0.0007
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.001 0.0314
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0012 0.0014
Onchocerca volvulus 0.0023 0.0004 0.0024
Brugia malayi hypothetical protein 0.005 0.0024 0.0152
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.0043 0.0019 0.0119
Echinococcus multilocularis integrin beta 2 0.015 0.0095 0.0611
Echinococcus multilocularis neuropeptides capa receptor 0.1211 0.085 0.5478
Toxoplasma gondii hypothetical protein 0.0019 0.0001 0.0018
Echinococcus granulosus integrin alpha ps 0.0044 0.0019 0.0124
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0385 0.0262 0.1686
Mycobacterium tuberculosis Probable histidinol dehydrogenase HisD (HDH) 1.4071 1 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0028 0.0183
Brugia malayi Kringle domain containing protein 0.0062 0.0032 0.0206
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0206 0.0135 0.6668
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.0208
Loa Loa (eye worm) integrin beta-2 0.0203 0.0132 0.0853
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0019 0.0001 0.0029
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0081 0.0093
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0001 0.0009
Chlamydia trachomatis glutamine binding protein 0.0028 0.0008 0.0086
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0085 0.0048 0.0642
Schistosoma mansoni hypothetical protein 0.0031 0.001 0.0011
Schistosoma mansoni hypothetical protein 0.022 0.0144 0.0165
Onchocerca volvulus 0.0281 0.0188 0.121
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0181 0.0117 0.0751
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0005 0.0051
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0264 0.0175 0.113
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0001 0.0006
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1211 0.085 0.0973
Echinococcus multilocularis alpha 1A adrenergic receptor 0.1211 0.085 0.5478
Onchocerca volvulus 0.0031 0.001 0.0063
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0846 0.0589 0.0675
Loa Loa (eye worm) hypothetical protein 0.0075 0.0041 0.0265
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0015 0.0098
Echinococcus granulosus phd:f box containing protein 0.0023 0.0004 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0009
Mycobacterium ulcerans polyketide synthase Pks13 0.0084 0.0048 0.0048
Trypanosoma cruzi DNA polymerase eta, putative 0.003 0.0009 0.0108
Brugia malayi Zinc carboxypeptidase family protein 0.0076 0.0042 0.0268
Schistosoma mansoni bromodomain containing protein 0.0071 0.0038 0.0043
Loa Loa (eye worm) hypothetical protein 0.0385 0.0262 0.1686
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0021 0.0003 0.0017
Schistosoma mansoni neuropeptide receptor 0.1211 0.085 0.0973
Echinococcus multilocularis rhodopsin orphan GPCR 0.1211 0.085 0.5478
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0085 0.0048 0.0639
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0018
Onchocerca volvulus 0.1211 0.085 0.5478
Onchocerca volvulus 0.1211 0.085 0.5478
Brugia malayi hypothetical protein 0.1211 0.085 0.5476
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0046 0.0021 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0001 0.0006
Echinococcus granulosus metabotropic glutamate receptor 5 0.0021 0.0003 0.0017
Schistosoma mansoni cathepsin D (A01 family) 0.0145 0.0091 0.0104
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Echinococcus granulosus neuropeptide receptor A26 0.158 0.1112 0.7167
Echinococcus multilocularis sterol O acyltransferase 1 0.0191 0.0124 0.0798
Echinococcus granulosus solute carrier family 22 0.0031 0.001 0.0062
Trypanosoma brucei glucose transporter, putative 0.0068 0.0036 0.0482
Brugia malayi CXXC zinc finger family protein 0.0043 0.0019 0.012
Giardia lamblia CDC72 0.0043 0.0019 0.0808
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0013 0.0199
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0019 0.0001 0.0001
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.2107 0.1487 0.9582
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0058 0.0029 0.0186
Loa Loa (eye worm) hypothetical protein 0.0383 0.026 0.1678
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0031 0.001 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.0208
Schistosoma mansoni tyrosine kinase 0.0076 0.0042 0.0047
Echinococcus multilocularis serotonin receptor 0.1211 0.085 0.5478
Echinococcus multilocularis neuropeptide FF receptor 2 0.1211 0.085 0.5478
Brugia malayi Sugar transporter family protein 0.0031 0.001 0.0063
Brugia malayi Furin-like cysteine rich region family protein 0.0144 0.009 0.0581
Plasmodium falciparum plasmepsin V 0.0023 0.0004 0.0045
Brugia malayi mbt repeat family protein 0.0066 0.0035 0.0223
Toxoplasma gondii transporter, major facilitator family protein 0.0031 0.001 0.0162
Mycobacterium tuberculosis Bacterioferritin BfrB 0.002 0.0002 0.0002
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0001 0.0001
Loa Loa (eye worm) hhat protein 0.0019 0.0001 0.0007
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.1211 0.085 0.0973
Schistosoma mansoni neurotransmitter gated ion channel 0.0385 0.0262 0.0299
Brugia malayi phosphofructokinase 0.0131 0.0081 0.0523
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0066 0.0035 0.0039
Echinococcus multilocularis insulin receptor 0.0047 0.0021 0.0136
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0019 0.0001 0.0001
Echinococcus granulosus aminopeptidase N 0.0685 0.0475 0.3063
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.0139 0.6889
Echinococcus granulosus polycomb protein SCMH1 0.0066 0.0035 0.0222
Echinococcus granulosus nmda type glutamate receptor 0.0254 0.0169 0.1086
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0846 0.0589 0.3799
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0004 0.0004
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0137 0.0085 0.0097
Echinococcus multilocularis histone deacetylase 3 0.0078 0.0044 0.028
Mycobacterium ulcerans Type I modular polyketide synthase 0.0056 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0018
Echinococcus multilocularis lysosomal alpha glucosidase 0.0108 0.0065 0.0416
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0019 0.0001 0.0006
Echinococcus multilocularis glutamate receptor 2 0.016 0.0102 0.0654
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.01 0.0059 0.0787
Loa Loa (eye worm) hypothetical protein 0.0385 0.0262 0.1686
Echinococcus multilocularis neuropeptide Y receptor 0.1211 0.085 0.5478
Trypanosoma cruzi Aminopeptidase M1, putative 0.0281 0.0188 0.2541
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0846 0.0589 0.3799
Schistosoma mansoni acetylcholine receptor-related 0.0385 0.0262 0.0299
Echinococcus granulosus zinc finger protein 0.0024 0.0005 0.0028
Loa Loa (eye worm) peptidase family M1 containing protein 0.0548 0.0378 0.2436
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0281 0.0188 0.121
Entamoeba histolytica hypothetical protein 0.0043 0.0019 0.0588
Schistosoma mansoni hypothetical protein 0.0066 0.0035 0.004
Leishmania major myo-inositol/proton symporter (MIT) 0.0031 0.001 0.0119
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.006 0.003 0.003
Echinococcus multilocularis dnaJ subfamily B 0.0327 0.0221 0.1422
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0019 0.0001 0.0006
Schistosoma mansoni zinc finger protein 0.0019 0.0001 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0083 0.0047 0.0303
Trypanosoma cruzi Cysteine peptidase, Clan CF, family C15 0.0519 0.0357 0.4844
Trypanosoma cruzi phytoene synthase, putative 0.0328 0.0221 0.2992
Brugia malayi excitatory GABA receptor EXP-1A 0.0846 0.0589 0.3799
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0007 0.0079
Leishmania major cytochrome p450-like protein 0.0127 0.0078 0.1054
Brugia malayi MBOAT family protein 0.0019 0.0001 0.0007
Trichomonas vaginalis alpha-glucosidase, putative 0.0024 0.0005 0.0232
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0027 0.0007 0.0343
Plasmodium falciparum phd finger protein, putative 0.0031 0.001 0.0151
Loa Loa (eye worm) matrix metalloproteinase 0.0021 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0063
Schistosoma mansoni alpha-glucosidase 0.0093 0.0054 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0001 0.0006
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0127 0.0078 0.1054
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0006
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0024 0.0005 0.0053
Loa Loa (eye worm) PXA domain-containing protein 0.0017 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Loa Loa (eye worm) MBOAT family protein 0.0019 0.0001 0.0007
Loa Loa (eye worm) hypothetical protein 0.1357 0.0953 0.6142
Echinococcus multilocularis zinc finger protein 0.0024 0.0005 0.0028
Brugia malayi neuropeptide F receptor 0.1211 0.085 0.5476
Echinococcus multilocularis nAChR subunit 0.0461 0.0316 0.2033
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.0139 0.6889
Trypanosoma brucei trypanothione reductase 0.0069 0.0037 0.049
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0846 0.0589 0.3799
Mycobacterium leprae putative cytochrome p450 0.0127 0.0078 0.0078
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.003 0.0009 0.006
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0066 0.0035 0.0224
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0063
Onchocerca volvulus 0.1211 0.085 0.5478
Schistosoma mansoni glutamate receptor AMPA 0.016 0.0102 0.0116
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0104 0.0062 0.0397
Trichomonas vaginalis sugar transporter, putative 0.0068 0.0036 0.1792
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0005 0.0051
Loa Loa (eye worm) G-protein coupled receptor 0.1211 0.085 0.5476
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0031 0.001 0.0011
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0173 0.0111 0.0713
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0032 0.042
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0846 0.0589 0.3799
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0127 0.0078 0.0078
Loa Loa (eye worm) TK/ROR protein kinase 0.0064 0.0034 0.0217
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0045 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.2197 0.1551 0.9996
Schistosoma mansoni hypothetical protein 0.0021 0.0003 0.0003
Brugia malayi Regulator of G protein signaling domain containing protein 0.0017 0 0.0001
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0181 0.0117 0.0751
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.0043 0.0019 0.0291
Schistosoma mansoni aldehyde dehydrogenase 0.0117 0.0071 0.0081
Trypanosoma cruzi PAB1-binding protein , putative 0.0037 0.0014 0.0176
Loa Loa (eye worm) hypothetical protein 0.0461 0.0316 0.2033
Schistosoma mansoni hypothetical protein 0.0403 0.0275 0.0315
Entamoeba histolytica Flap nuclease, putative 0.0031 0.001 0.0317
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0846 0.0589 0.3799
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Onchocerca volvulus Huntingtin homolog 0.0157 0.0099 0.0641
Leishmania major glucose transporter/membrane transporter D2, putative 0.0068 0.0036 0.048
Schistosoma mansoni hypothetical protein 0.0021 0.0003 0.0003
Trypanosoma cruzi hexose transporter, putative 0.0068 0.0036 0.048
Mycobacterium ulcerans leucyl aminopeptidase 0.0541 0.0373 0.0373
Onchocerca volvulus 0.0461 0.0316 0.2034
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0144 0.0091 0.1218
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0385 0.0262 0.1686
Loa Loa (eye worm) hypothetical protein 0.0461 0.0316 0.2033
Toxoplasma gondii hypothetical protein 0.0373 0.0253 0.4209
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Trichomonas vaginalis histone deacetylase, putative 0.0078 0.0044 0.2154
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0175 0.0112 0.0112
Trypanosoma brucei cytochrome P450, putative 0.0147 0.0092 0.1242
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Schistosoma mansoni hypothetical protein 0.005 0.0024 0.0027
Plasmodium vivax histone deacetylase, putative 0.0034 0.0012 0.0178
Plasmodium falciparum plasmepsin VIII, putative 0.0023 0.0004 0.0045
Echinococcus granulosus cpg binding protein 0.0048 0.0022 0.0139
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0001 0.0001
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.006 0.003 0.003
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.003 0.0009 0.0114
Entamoeba histolytica hypothetical protein, conserved 0.0019 0.0001 0.0029
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0127 0.0078 0.0078
Schistosoma mansoni hypothetical protein 0.0062 0.0032 0.0036
Loa Loa (eye worm) hypothetical protein 0.0023 0.0004 0.0024
Loa Loa (eye worm) glutaminase 2 0.0301 0.0202 0.1301
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.0441 0.0301 0.1944
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.2107 0.1487 0.9585
Onchocerca volvulus 0.1211 0.085 0.5478
Schistosoma mansoni sodium/hydrogen exchanger 2 (nhe2) 0.0264 0.0175 0.0201
Echinococcus multilocularis neuropeptide s receptor 0.158 0.1112 0.7167
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0127 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase Abl 0.0161 0.0102 0.0659
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0076 0.0042 0.2056
Brugia malayi Glycosyl hydrolases family 31 protein 0.0108 0.0065 0.0416
Loa Loa (eye worm) serotonin transporter b 0.2197 0.1551 0.9996
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Brugia malayi hypothetical protein 0.0031 0.001 0.0063
Brugia malayi Glutamate receptor 1 precursor 0.016 0.0102 0.0655
Echinococcus granulosus flap endonuclease 1 0.0031 0.001 0.0064
Echinococcus multilocularis allatostatin A receptor 0.1211 0.085 0.5478
Echinococcus multilocularis JmjC domain containing protein 4 0.0023 0.0004 0.0024
Echinococcus multilocularis sodium:hydrogen exchanger 0.0264 0.0175 0.113
Schistosoma mansoni hypothetical protein 0.0127 0.0078 0.009
Echinococcus granulosus cytosolic carboxypeptidase 1 0.0076 0.0042 0.0267
Echinococcus granulosus rhodopsin orphan GPCR 0.1211 0.085 0.5478
Trypanosoma cruzi pyroglutamyl-peptidase I, putative 0.0519 0.0357 0.4844
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0019 0.012
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0056 0.0028 0.018
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1211 0.085 0.5478
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0057 0.0028 0.0032
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0035 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0001 0.0006
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.022 0.0144 0.0929
Echinococcus granulosus synaptic vesicle 2 protein 0.0031 0.001 0.0062
Schistosoma mansoni peptide (allatostatin)-like receptor 0.1211 0.085 0.0973
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0076 0.0042 0.216
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0385 0.0262 0.1686
Echinococcus multilocularis muscleblind protein 0.0276 0.0184 0.1187
Onchocerca volvulus 0.0373 0.0253 0.1632
Loa Loa (eye worm) neuropeptide F receptor 0.1211 0.085 0.5476
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0029 0.0008 0.0054
Schistosoma mansoni histone deacetylase 0.0078 0.0044 0.005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0021 0.0003 0.0017
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.0038 0.0247
Leishmania major histone deacetylase, putative 0.0078 0.0044 0.0579
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0001 0.0006
Schistosoma mansoni glucose transport protein 0.022 0.0144 0.0165
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0081 0.4016
Brugia malayi hypothetical protein 0.0017 0 0.0001
Echinococcus granulosus microtubule associated protein 2 0.0777 0.054 0.3484
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Schistosoma mansoni ferritin 0.002 0.0002 0.0002
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0019 0.0001 0.0018
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.1211 0.085 0.5478
Loa Loa (eye worm) RGC/RGC protein kinase 0.0023 0.0004 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0001 0.0006
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0021 0.0003 0.0018
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0425 0.029 0.3935
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.0001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1211 0.085 0.5478
Loa Loa (eye worm) hypothetical protein 0.0846 0.0589 0.3799
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.003 0.0009 0.006
Giardia lamblia Hexose transporter 0.0031 0.001 0.0293
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0281 0.0188 0.121
Brugia malayi GnHR receptor homolog 0.139 0.0977 0.6295
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0016 0.0205
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0001 0.0006
Schistosoma mansoni sodium/hydrogen exchanger 0.0264 0.0175 0.0201
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0083 0.0047 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.0001
Brugia malayi regulator of G-protein signaling rgs-7 0.0017 0 0.0001
Onchocerca volvulus Fatty acid synthase homolog 0.0102 0.006 0.0388
Leishmania major histone deacetylase, putative 0.0078 0.0044 0.0579
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.005 0.0023 0.0027
Echinococcus multilocularis dna polymerase eta 0.003 0.0009 0.0057
Loa Loa (eye worm) hypothetical protein 0.0385 0.0262 0.1686
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0181 0.0117 0.0751
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.001 0.0065
Brugia malayi hypothetical protein 0.1211 0.085 0.5476
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0019 0.0002 0.0001
Echinococcus granulosus General substrate transporter 0.0189 0.0122 0.0787
Schistosoma mansoni peptidase 0.0076 0.0042 0.0047
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0081 0.0093
Echinococcus multilocularis rhodopsin orphan GPCR 0.1211 0.085 0.5478
Trichomonas vaginalis ferritin, putative 0.002 0.0002 0.0079
Brugia malayi hypothetical protein 0.0144 0.0091 0.0584
Schistosoma mansoni ferritin 0.002 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0036 0.1792
Mycobacterium ulcerans Type I modular polyketide synthase 0.0056 0.0028 0.0028
Brugia malayi Latrophilin receptor protein 2 0.0021 0.0003 0.0018
Onchocerca volvulus 0.1211 0.085 0.5478
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Echinococcus multilocularis histone deacetylase 6 0.0071 0.0038 0.0244
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0063
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Echinococcus granulosus tm gpcr rhodopsin 0.1211 0.085 0.5478
Schistosoma mansoni coup transcription factor 0.0019 0.0001 0.0001
Schistosoma mansoni metabotropic glutamate receptor 0.0021 0.0003 0.0003
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0031 0.001 0.0145
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Trypanosoma brucei histone deacetylase 3 0.0071 0.0038 0.0506
Plasmodium vivax JmjC domain containing protein 0.0023 0.0004 0.0048
Loa Loa (eye worm) hypothetical protein 0.0385 0.0262 0.1686
Onchocerca volvulus 0.1211 0.085 0.5478
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0281 0.0188 0.2543
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0007
Echinococcus multilocularis neuropeptides capa receptor 0.1211 0.085 0.5478
Onchocerca volvulus 0.0062 0.0032 0.0206
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0005 0.0051
Loa Loa (eye worm) hypothetical protein 0.0385 0.0262 0.1686
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0385 0.0262 0.1686
Echinococcus multilocularis histone deacetylase 1 0.0078 0.0044 0.028
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0037
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0016 0.0016
Trichomonas vaginalis sucrase-isomaltase, putative 0.0024 0.0005 0.0232
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0127 0.0078 0.0078
Brugia malayi Peptidase family M1 containing protein 0.0144 0.0091 0.0584
Schistosoma mansoni ferritin light chain 0.002 0.0002 0.0002
Brugia malayi G protein-coupled receptor F59B2.13 0.1211 0.085 0.5476
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0157 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0373 0.0253 0.1631
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0101 0.006 0.0059
Loa Loa (eye worm) hypothetical protein 0.0373 0.0253 0.1631
Brugia malayi mbt repeat family protein 0.0066 0.0035 0.0223
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0846 0.0589 0.0675
Echinococcus granulosus histone acetyltransferase MYST2 0.0075 0.0041 0.0264
Schistosoma mansoni sugar transporter 0.0031 0.001 0.0011
Echinococcus granulosus epidermal growth factor receptor 0.0144 0.009 0.058
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0066 0.0035 0.0224
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0076 0.0042 0.0692
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0001 0.0006
Brugia malayi gonadotropin-releasing hormone receptor 2 0.1211 0.085 0.5476
Loa Loa (eye worm) G-protein coupled receptor 0.1211 0.085 0.5476
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.1211 0.085 0.5478
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Toxoplasma gondii Na+/H+ exchanger NHE3 0.005 0.0024 0.0391
Brugia malayi jmjC domain containing protein 0.0023 0.0004 0.0025
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.029 0.0194 0.0222
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0001 0.0005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Trichomonas vaginalis sugar transporter, putative 0.0068 0.0036 0.1792
Loa Loa (eye worm) hypothetical protein 0.2197 0.1551 0.9996
Onchocerca volvulus 0.0685 0.0475 0.3064
Onchocerca volvulus 0.0846 0.0589 0.38
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0081 0.109
Plasmodium falciparum plasmepsin VI 0.0057 0.0028 0.0456
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.0208
Echinococcus multilocularis histone deacetylase 0.0071 0.0038 0.0244
Mycobacterium ulcerans bacterioferritin BfrA 0.002 0.0002 0.0002
Echinococcus granulosus expressed conserved protein 0.0051 0.0024 0.0153
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0018
Loa Loa (eye worm) norepinephrine transporter 0.2197 0.1551 0.9996
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0059 0.003 0.019
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0019 0.0001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0846 0.0589 0.3799
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0015 0.0098
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0024 0.0005 0.0082
Plasmodium vivax sodium/hydrogen exchanger 1, putative 0.005 0.0024 0.0375
Loa Loa (eye worm) hypothetical protein 0.012 0.0073 0.0472
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.001 0.0151
Brugia malayi AMP-binding enzyme family protein 0.0058 0.0029 0.0186
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0023 0.0004 0.0024
Schistosoma mansoni protein kinase 0.0023 0.0004 0.0005
Loa Loa (eye worm) melatonin receptor type 1A 0.1211 0.085 0.5476
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0016 0.0208
Loa Loa (eye worm) hypothetical protein 0.0461 0.0316 0.2033
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0425 0.029 0.3933
Echinococcus multilocularis G-protein coupled receptor, putative 0.1211 0.085 0.5478
Echinococcus multilocularis integrin alpha ps 0.0044 0.0019 0.0124
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0005 0.0051
Brugia malayi Tyrosine-protein kinase abl-1 0.0161 0.0102 0.066
Trypanosoma brucei glycerol uptake protein, putative 0.0019 0.0001 0.0003
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0004 0.0023
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0047 0.0021 0.0136
Brugia malayi hypothetical protein 0.0385 0.0262 0.1686
Loa Loa (eye worm) hypothetical protein 0.0037 0.0014 0.009
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0035 0.0013 0.0077
Loa Loa (eye worm) histone deacetylase 3 0.0078 0.0044 0.0281
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0001 0.0005
Schistosoma mansoni phd/f-box containing protein 0.0023 0.0004 0.0004
Schistosoma mansoni glutaminase 0.0301 0.0202 0.0231
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0127 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.1357 0.0953 0.6142
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0281 0.0188 0.0215
Echinococcus multilocularis somatostatin receptor 0.1211 0.085 0.5478
Brugia malayi Pepsin A precursor 0.0023 0.0004 0.0024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0385 0.0262 0.1686
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0021 0.0003 0.0018
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0127 0.0078 0.0078
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0373 0.0253 0.1631
Treponema pallidum NADH oxidase 0.0024 0.0005 0.0024
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0084 0.0048 0.0048
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Onchocerca volvulus 0.005 0.0024 0.0152
Onchocerca volvulus 0.1211 0.085 0.5478
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0005 0.0051
Mycobacterium ulcerans aldehyde dehydrogenase 0.0117 0.0071 0.0071
Brugia malayi PHD-finger family protein 0.0031 0.001 0.0065
Loa Loa (eye worm) hypothetical protein 0.005 0.0024 0.0152
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0037 0.0014 0.0092
Trypanosoma cruzi N-myristoyl transferase, putative 0.0043 0.0019 0.0238
Trichomonas vaginalis glucosylceramidase, putative 0.014 0.0087 0.4309
Schistosoma mansoni histone deacetylase 0.0078 0.0044 0.005
Schistosoma mansoni carboxypeptidase N (M14 family) 0.0076 0.0042 0.0047
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0018
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0024 0.0005 0.0053
Trypanosoma brucei histone deacetylase 1 0.0078 0.0044 0.0582
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.022 0.0144 0.0929
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0013 0.0637
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0019 0.0001 0.0006
Onchocerca volvulus 0.0031 0.001 0.0063
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0031 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0004 0.0029
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0058 0.0029 0.0029
Echinococcus granulosus rhodopsin orphan GPCR 0.1211 0.085 0.5478
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0023 0.0004 0.0029
Echinococcus multilocularis lysine specific demethylase 6a 0.0023 0.0004 0.0024
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0023 0.0004 0.0065
Loa Loa (eye worm) hypothetical protein 0.0053 0.0025 0.0163
Plasmodium vivax hypothetical protein, conserved 0.0373 0.0253 0.4199
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0018 0 0.0002
Echinococcus multilocularis integrin alpha ps 0.0044 0.0019 0.0124
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.006 0.003 0.003
Schistosoma mansoni apoferritin-2 0.002 0.0002 0.0002
Echinococcus granulosus sodium and chloride dependent glycine 0.0373 0.0253 0.1631
Onchocerca volvulus 0.0385 0.0262 0.1687
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0081 0.0523
Loa Loa (eye worm) hypothetical protein 0.0385 0.0262 0.1686
Trichomonas vaginalis histone deacetylase, putative 0.0078 0.0044 0.2154
Leishmania major extracellular receptor, putative 0.0021 0.0003 0.0023
Echinococcus multilocularis g protein coupled receptor 0.1211 0.085 0.5478
Trypanosoma cruzi trypanothione reductase, putative 0.0024 0.0005 0.0051
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0059 0.003 0.0034
Schistosoma mansoni hypothetical protein 0.0043 0.0019 0.0021
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Loa Loa (eye worm) TYRA-2 protein 0.1211 0.085 0.5476
Brugia malayi glutathione reductase 0.0069 0.0037 0.0238
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.0139 0.6889
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.0013 0.0408
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0373 0.0253 0.4209
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1211 0.085 0.5478
Schistosoma mansoni tyrosine kinase 0.0078 0.0043 0.0049
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0062 0.0071
Echinococcus granulosus metabotropic glutamate receptor 2 0.0021 0.0003 0.0017
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0846 0.0589 0.3799
Echinococcus granulosus rhodopsin orphan GPCR 0.1211 0.085 0.5478
Loa Loa (eye worm) hypothetical protein 0.0041 0.0017 0.0111
Toxoplasma gondii sodium/hydrogen exchanger 3 protein 0.005 0.0024 0.0391
Echinococcus multilocularis histone deacetylase 7 0.0071 0.0038 0.0244
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.0264 0.0175 0.113
Loa Loa (eye worm) hypothetical protein 0.0846 0.0589 0.3799
Brugia malayi hypothetical protein 0.1211 0.085 0.5476
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.002 0.0002 0.0001
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0127 0.0078 0.0078
Echinococcus granulosus rhodopsin orphan GPCR 0.1211 0.085 0.5478
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0063
Echinococcus multilocularis dna polymerase kappa 0.004 0.0016 0.0103
Schistosoma mansoni sterol O-acyltransferase 1 0.0191 0.0124 0.0142
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Echinococcus multilocularis g protein coupled receptor 0.1211 0.085 0.5478
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0083 0.0047 0.0054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0083 0.0047 0.0303
Onchocerca volvulus 0.0031 0.001 0.0063
Loa Loa (eye worm) hypothetical protein 0.0846 0.0589 0.3799
Onchocerca volvulus 0.0058 0.0029 0.0186
Brugia malayi hypothetical protein 0.0021 0.0003 0.0018
Trypanosoma cruzi aminopeptidase, putative 0.0281 0.0188 0.2541
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.003 0.0009 0.0117
Toxoplasma gondii sugar transporter ST1 0.0031 0.001 0.0162
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1211 0.085 0.0973
Plasmodium falciparum histone deacetylase 1 0.0078 0.0044 0.0709
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.003 0.0009 0.0011
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0263 0.0175 0.1125
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0206 0.0135 0.6668
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0846 0.0589 0.3799
Schistosoma mansoni hypothetical protein 0.005 0.0024 0.0027
Echinococcus granulosus Sugar transporter ERD6 protein 0.0031 0.001 0.0062
Schistosoma mansoni microtubule-associated protein tau 0.0777 0.054 0.0619
Loa Loa (eye worm) hypothetical protein 0.0385 0.0262 0.1686
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.003 0.0009 0.0461
Echinococcus granulosus neuropeptides capa receptor 0.1211 0.085 0.5478
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0018
Schistosoma mansoni cpg binding protein 0.0048 0.0022 0.0025
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0063
Trypanosoma brucei glucose transporter, putative 0.0068 0.0036 0.0482
Echinococcus multilocularis aminopeptidase N 0.0685 0.0475 0.3063
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.0038 0.0044
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0127 0.0078 0.0078
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.0025 0.0162
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Schistosoma mansoni tyrosine kinase 0.0023 0.0004 0.0005
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0085 0.0048 0.0639
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.005 0.0024 0.0023
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.01 0.0059 0.0787
Loa Loa (eye worm) hypothetical protein 0.0027 0.0007 0.0043
Brugia malayi hypothetical protein 0.0024 0.0005 0.003
Brugia malayi hypothetical protein 0.1211 0.085 0.5476
Echinococcus granulosus histone deacetylase 6 0.0071 0.0038 0.0244
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Echinococcus granulosus dna polymerase eta 0.003 0.0009 0.0057
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0024 0.0005 0.0062
Treponema pallidum sodium- and chloride- dependent transporter 0.2197 0.1551 1
Schistosoma mansoni biogenic amine receptor 0.1211 0.085 0.0973
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Plasmodium vivax aspartyl proteinase, putative 0.0023 0.0004 0.0045
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0001 0.0042
Echinococcus granulosus tachykinin peptides receptor 99D 0.1211 0.085 0.5478
Loa Loa (eye worm) solute carrier family 6 member 4 0.2197 0.1551 0.9996
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0001 0.0009
Echinococcus granulosus histone deacetylase 0.0071 0.0038 0.0244
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0108 0.0065 0.0416
Plasmodium vivax aspartyl protease, putative 0.0023 0.0004 0.0045
Brugia malayi Cytochrome P450 family protein 0.0147 0.0092 0.0594
Loa Loa (eye worm) glutaminase 0.0301 0.0202 0.1301
Plasmodium vivax aspartyl protease, putative 0.0023 0.0004 0.0045
Echinococcus multilocularis rhodopsin orphan GPCR 0.1211 0.085 0.5478
Schistosoma mansoni SET domain protein 0.0037 0.0014 0.0016
Echinococcus multilocularis muscleblind protein 1 0.0276 0.0184 0.1187
Loa Loa (eye worm) hypothetical protein 0.0191 0.0124 0.0798
Brugia malayi Matrixin family protein 0.0021 0.0003 0.0018
Entamoeba histolytica vacuolar protein sorting 26 0.0019 0.0001 0.0029
Treponema pallidum bacterioferrin (TpF1) 0.002 0.0002 0.0004
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1211 0.085 0.5478
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0144 0.0091 0.0583
Echinococcus multilocularis nAChR subunit 0.0846 0.0589 0.3799
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0095 0.0055 0.0354
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0076 0.0042 0.2056
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.0001
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0076 0.0042 0.0555
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.0208
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.006 0.003 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0005 0.0058
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0281 0.0188 0.121
Echinococcus granulosus rhodopsin orphan GPCR 0.1211 0.085 0.5478
Brugia malayi AKH receptor 0.1211 0.085 0.5476
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0024 0.0005 0.0148
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.003 0.0009 0.0461
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0206 0.0135 0.6668
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0127 0.0078 0.0078
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0074 0.0041 0.0261
Schistosoma mansoni leucine aminopeptidase 0.0085 0.0048 0.0055
Schistosoma mansoni tyrosine kinase 0.0023 0.0004 0.0005
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0001 0.0005
Loa Loa (eye worm) subtilase 0.0136 0.0085 0.0545
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0127 0.0078 0.0078
Echinococcus granulosus GPCR family 2 0.0021 0.0003 0.0017
Toxoplasma gondii sugar transporter ST3 0.0031 0.001 0.0162
Loa Loa (eye worm) hypothetical protein 0.0385 0.0262 0.1686
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0127 0.0078 0.1054
Trypanosoma cruzi Na/H antiporter-like protein, putative 0.005 0.0024 0.0306
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0016 0.0016
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0013 0.0199
Toxoplasma gondii sugar transporter ST2 0.0031 0.001 0.0162
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Loa Loa (eye worm) hypothetical protein 0.0846 0.0589 0.3799
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0076 0.0042 0.2056
Onchocerca volvulus 0.0031 0.001 0.0063
Brugia malayi hypothetical protein 0.0157 0.0099 0.0641
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0007 0.0043
Plasmodium falciparum amino acid transporter, putative 0.0373 0.0253 0.4199
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0846 0.0589 0.3799
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0001 0.0005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0001 0.0005
Echinococcus granulosus histone deacetylase 6 0.0073 0.0039 0.0254
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.003 0.0009 0.0295
Entamoeba histolytica acyl-CoA synthetase, putative 0.0022 0.0004 0.0114
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0281 0.0188 0.121
Echinococcus multilocularis rhodopsin orphan GPCR 0.1211 0.085 0.5478
Brugia malayi Pre-SET motif family protein 0.0227 0.0149 0.0961
Echinococcus multilocularis sodium and chloride dependent glycine 0.0373 0.0253 0.1631
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0001 0.0006
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0081 0.0523
Loa Loa (eye worm) runx1 0.0023 0.0004 0.0027
Trichomonas vaginalis histone deacetylase, putative 0.0078 0.0044 0.2154
Echinococcus multilocularis microtubule associated protein 2 0.0777 0.054 0.3484
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0016 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0001 0.0006
Echinococcus granulosus nmda type glutamate receptor 0.0181 0.0116 0.0749
Trypanosoma cruzi histone deacetylase 1, putative 0.0078 0.0044 0.0579
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.001 0.0063
Brugia malayi putative neuropeptide receptor NPR1 0.1211 0.085 0.5476
Loa Loa (eye worm) sodium-hydrogen exchanger NHE1 0.005 0.0024 0.0152
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0063
Mycobacterium leprae probable conserved integral membrane transport protein 0.005 0.0024 0.0023
Echinococcus multilocularis glutamate receptor 2 0.0115 0.007 0.0447
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0001 0.0001
Brugia malayi Peptidase family M1 containing protein 0.0281 0.0188 0.121
Echinococcus granulosus insulin receptor 0.0047 0.0021 0.0136
Echinococcus multilocularis L aminoadipate semialdehyde 0.0059 0.003 0.019
Echinococcus multilocularis integrin alpha 3 0.0076 0.0042 0.0269
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0127 0.0078 0.0078
Brugia malayi Flap endonuclease-1 0.0031 0.001 0.0065
Loa Loa (eye worm) hypothetical protein 0.0461 0.0316 0.2033
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0385 0.0262 0.1686
Loa Loa (eye worm) thioredoxin reductase 0.0069 0.0037 0.0238
Schistosoma mansoni cytochrome P450 0.0127 0.0078 0.009
Echinococcus multilocularis histone deacetylase 6 0.0071 0.0038 0.0244
Echinococcus granulosus integrin alpha ps 0.0021 0.0003 0.0018
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0373 0.0253 0.1631
Trypanosoma brucei DNA polymerase eta, putative 0.003 0.0009 0.0111
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1211 0.085 0.5478
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0057 0.0028 0.1402
Loa Loa (eye worm) TK/ABL protein kinase 0.0394 0.0268 0.1728
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0127 0.0078 0.0078
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0264 0.0175 0.113
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0019 0.0001 0.0001
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0328 0.0221 0.1424
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0144 0.0091 0.0103
Brugia malayi Protein kinase domain containing protein 0.0047 0.0021 0.0137
Leishmania major Na/H antiporter-like protein 0.005 0.0024 0.0306
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Mycobacterium ulcerans phytoene synthase, CrtB 0.0328 0.0221 0.0221
Echinococcus multilocularis glutamate receptor NMDA 0.016 0.0101 0.0652
Schistosoma mansoni hypothetical protein 0.1211 0.085 0.0973
Echinococcus granulosus nuclear factor of activated T cells 5 0.0035 0.0013 0.0081
Loa Loa (eye worm) matrixin family protein 0.0051 0.0024 0.0155
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0038 0.0509
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0018
Schistosoma mansoni hypothetical protein 0.0051 0.0024 0.0028
Loa Loa (eye worm) hypothetical protein 0.0373 0.0253 0.1631
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.01 0.0059 0.0787
Loa Loa (eye worm) glutathione reductase 0.0069 0.0037 0.0238
Loa Loa (eye worm) jmjC domain-containing protein 0.0023 0.0004 0.0025
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0083 0.0047 0.0304
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0281 0.0188 0.93
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0127 0.0078 0.0078
Loa Loa (eye worm) RGC/RGC protein kinase 0.0023 0.0004 0.0029
Loa Loa (eye worm) hypothetical protein 0.0032 0.001 0.0066
Echinococcus granulosus sterol O acyltransferase 1 0.0191 0.0124 0.0798
Echinococcus multilocularis expressed protein 0.0339 0.0229 0.1474
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0127 0.0078 0.0078
Mycobacterium tuberculosis Polyketide synthase Pks12 0.006 0.003 0.003
Brugia malayi Zinc carboxypeptidase family protein 0.0076 0.0042 0.0268
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0076 0.0042 0.0555
Schistosoma mansoni integrin alpha-ps 0.0044 0.0019 0.0022
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0127 0.0078 0.1054
Brugia malayi MBOAT family protein 0.0019 0.0001 0.0007
Echinococcus multilocularis glycine receptor subunit beta 0.0846 0.0589 0.3799
Schistosoma mansoni hypothetical protein 0.0076 0.0042 0.0047
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0024 0.0005 0.0031
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0846 0.0589 0.3799
Schistosoma mansoni tyrosine kinase 0.0388 0.0264 0.0302
Brugia malayi G-protein coupled receptor 0.1211 0.085 0.5476
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0019 0.0001 0.0029
Trypanosoma cruzi aminopeptidase, putative 0.0144 0.0091 0.1218
Echinococcus granulosus rhodopsin orphan GPCR 0.1211 0.085 0.5478
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.3038 0.215 0.2461
Brugia malayi Cation transporter family protein 0.0846 0.0589 0.3799
Trypanosoma brucei histone deacetylase 4 0.0071 0.0038 0.0506
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0031 0.001 0.001
Echinococcus granulosus tyrosine protein kinase ABL1 0.0394 0.0268 0.1727
Schistosoma mansoni memapsin-2 (A01 family) 0.0163 0.0104 0.0119
Brugia malayi PXA domain containing protein 0.0017 0 0.0001
Brugia malayi hypothetical protein 0.0385 0.0262 0.1686
Mycobacterium ulcerans aldehyde dehydrogenase 0.0117 0.0071 0.0071
Plasmodium falciparum plasmepsin II 0.0057 0.0028 0.0456
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0024 0.0005 0.0055
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0127 0.0078 0.0078
Trypanosoma cruzi Na/H antiporter-like protein, putative 0.005 0.0024 0.0306
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0001 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Echinococcus granulosus glutamate receptor NMDA 0.016 0.0101 0.0652
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0027 0.0007 0.0045
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0019 0.0001 0.0007
Brugia malayi larval opioid receptor 0.1211 0.085 0.5476
Loa Loa (eye worm) hypothetical protein 0.0846 0.0589 0.3799
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.015 0.0095 0.0609
Plasmodium falciparum plasmepsin I 0.0057 0.0028 0.0456
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.003 0.0009 0.0114
Mycobacterium tuberculosis Probable dehydrogenase 0.0157 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.2107 0.1487 0.9582
Onchocerca volvulus 0.0031 0.001 0.0063
Loa Loa (eye worm) hypothetical protein 0.0075 0.0041 0.0265
Toxoplasma gondii subtilisin SUB12 0.0021 0.0003 0.005
Schistosoma mansoni aldehyde dehydrogenase 0.0117 0.0071 0.0081
Loa Loa (eye worm) hypothetical protein 0.0404 0.0275 0.1774
Loa Loa (eye worm) hypothetical protein 0.0385 0.0262 0.1686
Schistosoma mansoni cpg binding protein 0.0048 0.0022 0.0025
Loa Loa (eye worm) glutamate receptor 0.0021 0.0003 0.0018
Mycobacterium ulcerans glutaminase 0.0301 0.0202 0.0202
Onchocerca volvulus 0.0385 0.0262 0.1687
Onchocerca volvulus 0.0441 0.0301 0.1944
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.0043 0.0019 0.0291
Trichomonas vaginalis alpha-glucosidase, putative 0.0024 0.0005 0.0232
Schistosoma mansoni tyrosine kinase 0.0144 0.009 0.0103
Echinococcus multilocularis rhodopsin orphan GPCR 0.1211 0.085 0.5478
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.001 0.0477
Onchocerca volvulus 0.0144 0.0091 0.0584
Loa Loa (eye worm) hypothetical protein 0.0385 0.0262 0.1686
Echinococcus granulosus G protein coupled receptor 139 0.1211 0.085 0.5478
Onchocerca volvulus 0.0441 0.0301 0.1944
Loa Loa (eye worm) hypothetical protein 0.0066 0.0035 0.0226
Loa Loa (eye worm) hypothetical protein 0.0541 0.0372 0.24
Loa Loa (eye worm) zinc carboxypeptidase 0.0076 0.0042 0.0268
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0061
Plasmodium falciparum ataxin-2 like protein, putative 0.0037 0.0014 0.0216
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0541 0.0373 1
Loa Loa (eye worm) neuropeptide F receptor 0.1211 0.085 0.5476
Echinococcus granulosus lysine specific demethylase 5A 0.009 0.0052 0.0332
Schistosoma mansoni metallocarboxypeptidase D peptidase unit 2 (M14 family) 0.0076 0.0042 0.0047
Loa Loa (eye worm) hypothetical protein 0.0846 0.0589 0.3799
Brugia malayi Dopamine receptor protein 2 0.1211 0.085 0.5476
Plasmodium falciparum plasmepsin X 0.0023 0.0004 0.0045
Loa Loa (eye worm) RGC/RGC protein kinase 0.0023 0.0004 0.0029
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0137 0.0085 0.1142
Echinococcus granulosus histone deacetylase 1 0.0078 0.0044 0.028
Onchocerca volvulus Matrix metalloproteinase homolog 0.0047 0.0021 0.0135
Mycobacterium tuberculosis Probable thioesterase TesA 0.0047 0.0021 0.0021
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0013 0.0482
Schistosoma mansoni opsin-like receptor 0.1211 0.085 0.0973
Brugia malayi cytosol aminopeptidase 0.0085 0.0048 0.0309
Loa Loa (eye worm) hypothetical protein 0.0076 0.0042 0.0268
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0085 0.0048 0.0639
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0846 0.0589 0.3799
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0039
Entamoeba histolytica sodium/proton antiporter, putative 0.005 0.0024 0.0742
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0056 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0005 0.0051
Schistosoma mansoni hypothetical protein 0.0046 0.002 0.0023
Schistosoma mansoni jumonji domain containing protein 0.0129 0.0079 0.0091
Brugia malayi Bromodomain containing protein 0.0041 0.0017 0.0111
Echinococcus multilocularis thioredoxin glutathione reductase 0.0069 0.0037 0.0239
Schistosoma mansoni alpha glucosidase 0.0024 0.0005 0.0005
Leishmania major histone deacetylase, putative 0.0071 0.0038 0.0503
Echinococcus granulosus orexin receptor type 2 0.1211 0.085 0.5478
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0004 0.0004
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0078 0.0043 0.0278
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0001 0.0001
Schistosoma mansoni adenoreceptor 0.1211 0.085 0.0973
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0441 0.0301 0.0345
Trypanosoma cruzi squalene synthase, putative 0.1051 0.0736 1
Brugia malayi Dopamine receptor 0.1211 0.085 0.5476
Leishmania major cytochrome p450-like protein 0.0127 0.0078 0.1054
Loa Loa (eye worm) MBCTL1 0.0075 0.0041 0.0265
Trypanosoma brucei glucose transporter, putative 0.0068 0.0036 0.0482
Onchocerca volvulus 0.0103 0.0061 0.0395
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0019 0.0121
Trypanosoma cruzi histone deacetylase, putative 0.0071 0.0038 0.0503
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0066 0.0035 0.0224
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0025 0.0029
Loa Loa (eye worm) hypothetical protein 0.0078 0.0044 0.0281
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.0038 0.0248
Echinococcus multilocularis leucyl aminopeptidase 0.0085 0.0048 0.0309
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0846 0.0589 0.3799
Brugia malayi Dopamine receptor protein 1 0.1211 0.085 0.5476
Echinococcus multilocularis g protein coupled receptor 0.1211 0.085 0.5478
Trypanosoma brucei THT1 - hexose transporter, putative 0.0068 0.0036 0.0482
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0021 0.0003 0.0017
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0181 0.0117 0.0751
Onchocerca volvulus Huntingtin homolog 0.0157 0.0099 0.0641
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0117 0.0071 0.0952
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0001 0.0002
Brugia malayi Hhat protein 0.0019 0.0001 0.0007
Toxoplasma gondii type I fatty acid synthase, putative 0.004 0.0016 0.0272
Echinococcus granulosus o acyltransferase membrane bound domain 0.0019 0.0001 0.0006
Echinococcus multilocularis GPCR, family 2 0.0021 0.0003 0.0017
Loa Loa (eye worm) hypothetical protein 0.0076 0.0042 0.0268
Echinococcus granulosus ubiquitin specific protease 41 0.003 0.0009 0.006
Schistosoma mansoni growth hormone secretagogue receptor 0.1211 0.085 0.0973
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0013 0.0216
Loa Loa (eye worm) hypothetical protein 0.0846 0.0589 0.3799
Schistosoma mansoni glutamate receptor kainate 0.016 0.0102 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0144 0.7144
Mycobacterium ulcerans aldehyde dehydrogenase 0.0117 0.0071 0.0071
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0001 0.0001
Schistosoma mansoni histone deacetylase 4 5 0.0071 0.0038 0.0043
Leishmania major DNA polymerase eta, putative 0.003 0.0009 0.0108
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0101 0.006 0.0059
Brugia malayi Cytochrome P450 family protein 0.0127 0.0078 0.0506
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0024 0.0005 0.0031
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0019 0.0001 0.0001
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0023 0.0004 0.0004
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.001 0.0169
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0127 0.0078 0.0078
Schistosoma mansoni integrin beta subunit 0.012 0.0073 0.0083
Leishmania major alpha glucosidase II subunit, putative 0.0024 0.0005 0.0051
Echinococcus granulosus cytosolic carboxypeptidase protein 5 0.0076 0.0042 0.0267
Trypanosoma brucei aminopeptidase, putative 0.0144 0.0091 0.122
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0024 0.0005 0.0053
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.1211 0.085 0.5476
Brugia malayi hypothetical protein 0.0184 0.0119 0.0766
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.0001
Onchocerca volvulus 0.0031 0.001 0.0063
Brugia malayi Sugar transporter family protein 0.0031 0.001 0.0063
Echinococcus granulosus alpha 1A adrenergic receptor 0.1211 0.085 0.5478
Onchocerca volvulus 0.0031 0.001 0.0063
Echinococcus granulosus solute carrier family 22 0.0031 0.001 0.0062
Schistosoma mansoni hypothetical protein 0.1211 0.085 0.0973
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Trypanosoma cruzi PAB1-binding protein , putative 0.0037 0.0014 0.0176
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0024 0.0005 0.0062
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1211 0.085 0.0973
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0001 0.0006
Trichomonas vaginalis histone deacetylase, putative 0.0078 0.0044 0.2154
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0281 0.0188 0.121
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0024 0.0005 0.003
Brugia malayi 6-phosphofructokinase 0.0131 0.0081 0.0523
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0127 0.0078 0.0078
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0024 0.0005 0.0005
Brugia malayi major facilitator superfamily protein 0.0031 0.001 0.0063
Leishmania major DNA polymerase kappa, putative 0.0024 0.0005 0.0055
Onchocerca volvulus 0.2197 0.1551 1
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.001 0.0169
Brugia malayi aspartic protease BmAsp-2, identical 0.0023 0.0004 0.0024
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0001 0.0001
Loa Loa (eye worm) ACC-1 protein 0.0846 0.0589 0.3799
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0117 0.0071 0.0457
Toxoplasma gondii histone deacetylase HDAC3 0.0078 0.0044 0.0725
Echinococcus granulosus glycine receptor subunit beta 0.0846 0.0589 0.3799
Brugia malayi hypothetical protein 0.1211 0.085 0.5476
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0081 0.2569
Loa Loa (eye worm) hypothetical protein 0.0846 0.0589 0.3799
Brugia malayi 6-phosphofructokinase 0.0131 0.0081 0.0523
Toxoplasma gondii sodium/hydrogen exchanger NHE2 0.005 0.0024 0.0391
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0029 0.0008 0.0053
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.022 0.0144 0.0929
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0846 0.0589 0.3799
Plasmodium falciparum sodium/hydrogen exchanger, Na+, H+ antiporter 0.005 0.0024 0.0375
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0006
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.0264 0.0175 0.113
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0136 0.0085 0.0097
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0127 0.0078 0.0078
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0085 0.0048 0.0309
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0024 0.0005 0.0005
Trypanosoma brucei unspecified product 0.0035 0.0013 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0001 0.0045
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0385 0.0262 0.1686
Schistosoma mansoni nAChR subunit 0.0846 0.0589 0.0675
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0127 0.0078 0.1054
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0027 0.0007 0.0045
Loa Loa (eye worm) hypothetical protein 0.2198 0.1552 1
Trypanosoma cruzi cytochrome P450, putative 0.0147 0.0092 0.124
Trypanosoma brucei glucose transporter, putative 0.0068 0.0036 0.0482
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0063
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0385 0.0262 0.1686
Trichomonas vaginalis glucosylceramidase, putative 0.014 0.0087 0.4309
Loa Loa (eye worm) zinc carboxypeptidase 0.0076 0.0042 0.0268
Trichomonas vaginalis alpha-glucosidase, putative 0.0024 0.0005 0.0232
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Echinococcus multilocularis Zinc carboxypeptidase family protein 0.0076 0.0042 0.0267
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.0073 0.0472
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0281 0.0188 0.121
Brugia malayi N-myristoyltransferase 2 0.0043 0.0019 0.012
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0075 0.0041 0.0265
Echinococcus granulosus nAChR subunit 0.0846 0.0589 0.3799
Echinococcus multilocularis geminin 0.0051 0.0024 0.0155
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0066 0.0035 0.0223
Mycobacterium leprae Conserved hypothetical protein 0.0127 0.0078 0.0078
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0012 0.0203
Loa Loa (eye worm) CXXC zinc finger family protein 0.0043 0.0019 0.012
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0127 0.0078 0.0078
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0057 0.0028 0.0473
Echinococcus multilocularis polycomb protein SCMH1 0.0066 0.0035 0.0222
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.1211 0.085 0.5476
Onchocerca volvulus 0.0846 0.0589 0.38
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0013 0.0223
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0026 0.0006 0.0039
Loa Loa (eye worm) hypothetical protein 0.0385 0.0262 0.1686
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0127 0.0078 0.0078
Schistosoma mansoni sodium-dependent amino acid transporter 0.0373 0.0253 0.029
Giardia lamblia PHD finger protein 15 0.0031 0.001 0.0315
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0025 0.0029
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0076 0.0042 0.0552
Plasmodium vivax ataxin-2 like protein, putative 0.0037 0.0014 0.0216
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0028 0.0008 0.0008
Brugia malayi follicle stimulating hormone receptor 0.1472 0.1035 0.6669
Echinococcus multilocularis expressed protein 0.002 0.0002 0.001
Loa Loa (eye worm) MBOAT family protein 0.0019 0.0001 0.0007
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0078 0.0044 0.2154
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.0081 0.0522
Brugia malayi hypothetical protein 0.0385 0.0262 0.1686
Echinococcus multilocularis peregrin 0.0044 0.0019 0.0123
Leishmania major hypothetical protein, conserved 0.0328 0.0221 0.2992
Trypanosoma brucei glucosidase, putative 0.0024 0.0005 0.0054
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.1211 0.085 0.0973
Echinococcus multilocularis integrin alpha ps 0.0021 0.0003 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.0139 0.6889
Plasmodium vivax hexose transporter 0.022 0.0144 0.2385
Toxoplasma gondii leucyl aminopeptidase LAP 0.0541 0.0373 0.6204
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0021 0.0003 0.0003
Trichomonas vaginalis maltase-glucoamylase, putative 0.0024 0.0005 0.0232
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0045 0.002 0.002
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.2107 0.1487 0.9585
Echinococcus multilocularis synaptic vesicle 2 protein 0.0031 0.001 0.0062
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.2107 0.1487 0.9585
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0021 0.0003 0.0017
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0031 0.001 0.0121
Brugia malayi jmjC domain containing protein 0.0023 0.0004 0.0025
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0076 0.0042 0.216
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0013 0.0637
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0846 0.0589 0.3799
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.0208
Plasmodium falciparum JmjC domain-containing protein, putative 0.0023 0.0004 0.0048
Brugia malayi Matrixin family protein 0.0051 0.0024 0.0155
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.1211 0.085 0.5478
Schistosoma mansoni hypothetical protein 0.0021 0.0003 0.0003
Brugia malayi Histone deacetylase family protein 0.0071 0.0038 0.0245
Onchocerca volvulus 0.1211 0.085 0.5478
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Schistosoma mansoni biogenic amine receptor 0.1211 0.085 0.0973
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0019 0.0022
Leishmania major glucose transporter, lmgt1 0.0068 0.0036 0.048
Loa Loa (eye worm) hypothetical protein 0.0373 0.0253 0.1631
Echinococcus multilocularis rho associated protein kinase 0.0044 0.0019 0.0122
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1472 0.1035 0.6669
Schistosoma mansoni N-myristoyltransferase 0.0043 0.0019 0.0021
Brugia malayi TATA binding protein associated factor 0.0144 0.0091 0.0584
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0085 0.0048 0.0642
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0024 0.0005 0.0051
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0051 0.0024 0.0154
Echinococcus granulosus serotonin transporter 0.2197 0.1551 1
Onchocerca volvulus 0.0031 0.001 0.0063
Trypanosoma brucei hypothetical protein, conserved 0.01 0.0059 0.079
Echinococcus multilocularis serotonin receptor 0.1211 0.085 0.5478
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0081 0.4016
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.0208
Leishmania major glucose transporter, lmgt3 0.0068 0.0036 0.048
Brugia malayi hypothetical protein 0.0037 0.0014 0.009
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0846 0.0589 0.3799
Brugia malayi Eukaryotic aspartyl protease family protein 0.0023 0.0004 0.0024
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0016 0.0793
Schistosoma mansoni ferritin 0.002 0.0002 0.0002
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0846 0.0589 0.3799
Echinococcus granulosus neutral alpha glucosidase AB 0.0024 0.0005 0.003
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0055 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0264 0.0175 0.113
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0021 0.0003 0.0018
Onchocerca volvulus 0.003 0.0009 0.0058
Toxoplasma gondii thioredoxin reductase 0.0069 0.0037 0.0613
Schistosoma mansoni nAChR subunit 0.0846 0.0589 0.0675
Echinococcus multilocularis flap endonuclease 1 0.0031 0.001 0.0064
Brugia malayi cytochrome P450 0.0127 0.0078 0.0506
Brugia malayi hypothetical protein 0.2198 0.1552 1
Loa Loa (eye worm) hypothetical protein 0.0461 0.0316 0.2033
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0069 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0137 0.0085 0.0548
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0001 0.0001
Loa Loa (eye worm) RGS-3 protein 0.0017 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0385 0.0262 0.1686
Brugia malayi Carboxypeptidase A2 precursor 0.0076 0.0042 0.0268
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0127 0.0078 0.0078
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0087 0.005 0.0321
Plasmodium falciparum M17 leucyl aminopeptidase 0.0425 0.029 0.4814
Mycobacterium tuberculosis Probable reductase 0.0157 0.01 0.01
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.1211 0.085 0.5476
Trypanosoma cruzi cytochrome P450, putative 0.0147 0.0092 0.124
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.001 0.0065
Entamoeba histolytica hypothetical protein 0.0043 0.0019 0.0588
Loa Loa (eye worm) histone deacetylase 7A 0.0071 0.0038 0.0245
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0281 0.0188 0.2541
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0006
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0117 0.0071 0.0457
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0076 0.0042 0.2056
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1211 0.085 0.0973
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0385 0.0262 0.1686
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.0139 0.6889
Loa Loa (eye worm) hypothetical protein 0.0076 0.0042 0.0268
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0019 0.0001 0.0006
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Echinococcus granulosus tissue type plasminogen activator 0.0062 0.0032 0.0205
Onchocerca volvulus 0.0019 0.0001 0.0006
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Brugia malayi MBOAT family protein 0.0019 0.0001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0096 0.0056 0.0359
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0045 0.002 0.002
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0031 0.001 0.001
Leishmania major hypothetical protein, conserved 0.0031 0.001 0.0119
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0018
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0004 0.0004
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0056 0.0028 0.0028
Echinococcus multilocularis tachykinin peptides receptor 99D 0.1211 0.085 0.5478
Schistosoma mansoni amine GPCR 0.1211 0.085 0.0973
Brugia malayi Receptor family ligand binding region containing protein 0.0021 0.0003 0.0018
Echinococcus multilocularis dro:myosuppressin receptor 0.1211 0.085 0.5478
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0019 0.0001 0.0029
Loa Loa (eye worm) zinc carboxypeptidase 0.0076 0.0042 0.0268
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0083 0.0047 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0001 0.0006
Schistosoma mansoni nAChR subunit 0.0846 0.0589 0.0675
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0076 0.0042 0.2056
Echinococcus multilocularis rhodopsin orphan GPCR 0.1211 0.085 0.5478
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0036 0.1792
Brugia malayi Cytochrome P450 family protein 0.0144 0.009 0.0581
Trypanosoma brucei glucose transporter, putative 0.0068 0.0036 0.0482
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0021 0.0003 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0013 0.0637
Brugia malayi hypothetical protein 0.0031 0.001 0.0063
Schistosoma mansoni histone deacetylase hda2 0.0034 0.0012 0.0013
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0001 0.0005
Echinococcus granulosus dna polymerase kappa 0.004 0.0016 0.0103
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0024 0.0005 0.008
Schistosoma mansoni peptidase 0.0076 0.0042 0.0047
Schistosoma mansoni sodium/chloride dependent transporter 0.0373 0.0253 0.029
Brugia malayi Tyrosine-protein kinase abl-1 0.0238 0.0157 0.1014
Brugia malayi Peptidase family M1 containing protein 0.0685 0.0475 0.3063
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0075 0.0041 0.0264
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Schistosoma mansoni neuropeptide f receptor 76f 0.1211 0.085 0.0973
Loa Loa (eye worm) hypothetical protein 0.0157 0.0099 0.0641
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0385 0.0262 0.1686
Loa Loa (eye worm) fatty acid synthase 0.0056 0.0027 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.001 0.0477
Echinococcus multilocularis tissue type plasminogen activator 0.0062 0.0032 0.0205
Schistosoma mansoni neuropeptide receptor 0.1211 0.085 0.0973
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0019 0.0001 0.0018
Onchocerca volvulus Putative nachr subunit 0.2107 0.1487 0.9585
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.001 0.0477
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.1211 0.085 0.5478
Echinococcus multilocularis serotonin transporter 0.2197 0.1551 1
Brugia malayi PXA domain containing protein 0.0017 0 0.0001
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0014 0.018
Entamoeba histolytica hypothetical protein 0.0461 0.0316 1
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Schistosoma mansoni cathepsin D (A01 family) 0.0145 0.0091 0.0104
Echinococcus granulosus 7tm_1 domain containing protein 0.1211 0.085 0.5478
Plasmodium falciparum flap endonuclease 1 0.0031 0.001 0.0151
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0019 0.0021
Trypanosoma cruzi squalene synthase, putative 0.1051 0.0736 1
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0057 0.0028 0.0183
Brugia malayi Metabotropic glutamate receptor precursor. 0.0021 0.0003 0.0018
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.1211 0.085 0.5478
Loa Loa (eye worm) cytochrome P450 family protein 0.0147 0.0092 0.0594
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0862 0.0601 1
Brugia malayi jmjC domain containing protein 0.015 0.0095 0.0609
Schistosoma mansoni glutamate receptor NMDA 0.0341 0.023 0.0263
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0144 0.0091 0.1218
Onchocerca volvulus 0.0031 0.001 0.0063
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0032 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0066 0.0035 0.0223
Brugia malayi Bromodomain containing protein 0.0034 0.0012 0.0077
Brugia malayi Cation transporter family protein 0.0846 0.0589 0.3799
Onchocerca volvulus 0.0031 0.001 0.0063
Loa Loa (eye worm) hypothetical protein 0.0461 0.0316 0.2033
Schistosoma mansoni alpha-1 adrenergic receptor 0.1211 0.085 0.0973
Brugia malayi hypothetical protein 0.0385 0.0262 0.1686
Schistosoma mansoni family M14 non-peptidase homologue (M14 family) 0.0076 0.0042 0.0047
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0127 0.0078 0.0078
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0042 0.0676
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.0264 0.0175 0.1131
Onchocerca volvulus Carboxypeptidase D homolog 0.0076 0.0042 0.0268
Brugia malayi Cation transporter family protein 0.0846 0.0589 0.3799
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.2107 0.1487 0.9585
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0066 0.0035 0.0224
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.0264 0.0175 0.1131
Echinococcus granulosus serotonin receptor 0.1211 0.085 0.5478
Loa Loa (eye worm) cytochrome P450 family protein 0.0147 0.0092 0.0594
Onchocerca volvulus 0.1211 0.085 0.5478
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0017 0.0109
Brugia malayi Stress-activated protein kinase jnk-1 0.0104 0.0062 0.0398
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0024 0.0005 0.0051
Mycobacterium ulcerans hydrolase 0.0026 0.0006 0.0006
Echinococcus granulosus sex peptide receptor 0.1211 0.085 0.5478
Plasmodium vivax amine transporter, putative 0.0373 0.0253 0.4199
Onchocerca volvulus 0.0258 0.0171 0.1104
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0034 0.0219
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0552 0.0381 0.0436
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0461 0.0316 0.2033
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0001 0.0006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0846 0.0589 0.3799
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1211 0.085 0.0973
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0085 0.0048 0.0309
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Echinococcus multilocularis Protein lozenge 0.0023 0.0004 0.0026
Plasmodium vivax aspartyl protease, putative 0.0023 0.0004 0.0045
Brugia malayi Subtilase family protein 0.0136 0.0085 0.0545
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0066 0.0035 0.0224
Brugia malayi Bromodomain containing protein 0.0083 0.0047 0.0304
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0846 0.0589 0.0675
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0001 0.0001
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.001 0.0124
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0281 0.0188 0.121
Echinococcus granulosus L aminoadipate semialdehyde 0.0059 0.003 0.019
Trypanosoma brucei Carboxypeptidase-like protein 0.0076 0.0042 0.0555
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0373 0.0253 0.6744
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0076 0.0042 0.0552
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0016 0.0793
Echinococcus granulosus nAChR subunit 0.0461 0.0316 0.2033
Echinococcus multilocularis histone deacetylase 8 0.0034 0.0012 0.0075
Entamoeba histolytica hypothetical protein 0.0043 0.0019 0.0588
Loa Loa (eye worm) hypothetical protein 0.0023 0.0004 0.0025
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0001 0.0005
Echinococcus granulosus sodium:hydrogen exchanger 0.0264 0.0175 0.113
Echinococcus multilocularis 0.0127 0.0078 0.0505
Plasmodium falciparum plasmepsin IV 0.0057 0.0028 0.0456
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0023 0.0004 0.0004
Leishmania major hypothetical protein, conserved 0.0023 0.0004 0.0039
Echinococcus multilocularis solute carrier family 22 0.0031 0.001 0.0062
Schistosoma mansoni protease m14 carboxypeptidase 0.0076 0.0042 0.0047
Brugia malayi Matrixin family protein 0.0021 0.0003 0.0018
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0076 0.0042 0.2056
Schistosoma mansoni nAChR subunit 0.0846 0.0589 0.0675
Schistosoma mansoni integrin alpha 0.0099 0.0058 0.0067
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0001 0.0001
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0373 0.0253 0.029
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0385 0.0262 0.1686
Echinococcus granulosus sodium:hydrogen exchanger 0.0264 0.0175 0.113
Echinococcus multilocularis tyrosine kinase 0.0023 0.0004 0.0028
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.0081 0.0517
Echinococcus multilocularis ubiquitin specific protease 41 0.003 0.0009 0.006
Schistosoma mansoni sugar transporter 0.0031 0.001 0.0011
Plasmodium falciparum histone deacetylase, putative 0.0071 0.0038 0.0616
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0127 0.0078 0.0078
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0213 0.014 0.0899
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0076 0.0042 0.2056
Schistosoma mansoni cpg binding protein 0.0043 0.0019 0.0021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0001 0.0005
Trypanosoma cruzi sodium/hydrogen exchanger, putative 0.005 0.0024 0.0306
Loa Loa (eye worm) hypothetical protein 0.0846 0.0589 0.3799
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0016 0.0205
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0013 0.0216
Echinococcus granulosus jumonji domain containing 1A 0.0023 0.0004 0.0024
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0055 0.0027 0.0027
Brugia malayi latrophilin 2 splice variant baaae 0.0046 0.002 0.0131
Mycobacterium leprae Polyketide synthase Pks13 0.0084 0.0048 0.0047
Plasmodium vivax histone deacetylase 2, putative 0.0071 0.0038 0.0616
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Brugia malayi hypothetical protein 0.1211 0.085 0.5476
Schistosoma mansoni tyrosine kinase 0.0078 0.0043 0.0049
Loa Loa (eye worm) GABA receptor subunit 0.0461 0.0316 0.2033
Brugia malayi Histone deacetylase 1 0.0078 0.0044 0.0281
Plasmodium vivax sugar transporter, putative 0.0031 0.001 0.0145
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.0081 0.0522
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0076 0.0042 0.0552
Echinococcus granulosus peregrin 0.0044 0.0019 0.0123
Loa Loa (eye worm) latrophilin receptor protein 2 0.0021 0.0003 0.0018
Brugia malayi Guanylyl cyclase protein 23 0.0023 0.0004 0.0029
Brugia malayi Hemopexin family protein 0.003 0.0009 0.0058
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0001 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0127 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0023 0.0004 0.0024
Trypanosoma brucei histone deacetylase 2 0.0034 0.0012 0.0148
Brugia malayi Glutamate receptor 2 precursor 0.016 0.0102 0.0655
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0127 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0184 0.0119 0.0766
Toxoplasma gondii aminopeptidase N protein 0.0862 0.0601 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1211 0.085 0.0973
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.001 0.0063
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.1211 0.085 0.5478
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0127 0.0078 0.0078
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0461 0.0316 0.2033
Schistosoma mansoni protein phosphatase 2C 0.0023 0.0004 0.0004
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.022 0.0144 0.0929
Onchocerca volvulus 0.0034 0.0012 0.0079
Echinococcus multilocularis sodium:hydrogen exchanger 7 0.005 0.0024 0.0151
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0031 0.001 0.001
Loa Loa (eye worm) CYP4Cod1 0.0147 0.0092 0.0594
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.022 0.0144 0.0929
Echinococcus granulosus solute carrier family 22 0.0031 0.001 0.0062
Loa Loa (eye worm) LGC-31 protein 0.0846 0.0589 0.3799
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0206 0.0135 0.6668
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Onchocerca volvulus 0.0461 0.0316 0.2034
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0078 0.0044 0.2154
Echinococcus multilocularis cpg binding protein 0.0048 0.0022 0.0139
Trichomonas vaginalis histone deacetylase, putative 0.0078 0.0044 0.2154
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1211 0.085 0.0973
Trypanosoma cruzi histone deacetylase, putative 0.0071 0.0038 0.0503
Plasmodium falciparum plasmepsin IX 0.0023 0.0004 0.0045
Brugia malayi histone deacetylase 11 0.0034 0.0012 0.0076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0127 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0264 0.0175 0.113
Echinococcus granulosus integrin alpha 3 0.0076 0.0042 0.0269
Brugia malayi POT family protein 0.0049 0.0023 0.0147
Brugia malayi histone deacetylase 1 (HD1) 0.0078 0.0044 0.0281
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.1211 0.085 0.5478
Giardia lamblia Sugar-proton symporter 0.0031 0.001 0.0293
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0144 0.0091 0.1218
Onchocerca volvulus Matrilysin homolog 0.0047 0.0021 0.0135
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0076 0.0042 0.0552
Schistosoma mansoni neurotransmitter gated ion channel 0.0385 0.0262 0.0299
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0846 0.0589 0.3799
Loa Loa (eye worm) phosphofructokinase 0.0131 0.0081 0.0523
Echinococcus granulosus rho-associated protein kinase 1 0.0044 0.0019 0.0122
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0019 0.0001 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0007 0.0079
Loa Loa (eye worm) hypothetical protein 0.0076 0.0042 0.0271
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0024 0.0005 0.0051
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0021 0.0003 0.0018
Loa Loa (eye worm) POT family protein 0.0049 0.0023 0.0147
Echinococcus granulosus g protein coupled receptor 0.1211 0.085 0.5478
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0127 0.0078 0.0078
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0101 0.006 0.0059
Brugia malayi hypothetical protein 0.0023 0.0004 0.0024
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0017 0 0.0001
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.1211 0.085 0.5478
Echinococcus granulosus lysine specific demethylase 6a 0.0023 0.0004 0.0024
Onchocerca volvulus 0.1211 0.085 0.5478
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0425 0.029 0.3933
Echinococcus granulosus thyrotropin releasing hormone receptor 0.1211 0.085 0.5478
Trichomonas vaginalis set domain proteins, putative 0.0258 0.0171 0.8477
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0019 0.0001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0846 0.0589 0.3799
Brugia malayi Cytochrome P450 family protein 0.0147 0.0092 0.0594
Echinococcus multilocularis solute carrier family 22 0.0031 0.001 0.0062
Toxoplasma gondii aspartyl protease 0.0023 0.0004 0.0063
Onchocerca volvulus Cytosolic carboxypeptidase 1 homolog 0.0076 0.0042 0.0268
Onchocerca volvulus 0.0023 0.0004 0.0029
Schistosoma mansoni amine GPCR 0.1211 0.085 0.0973
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0175 0.0112 0.0112
Brugia malayi Zinc carboxypeptidase family protein 0.0076 0.0042 0.0268
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0175 0.0112 0.0112
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0373 0.0253 0.029
Echinococcus granulosus sodium and chloride dependent glycine 0.0373 0.0253 0.1631
Onchocerca volvulus 0.0441 0.0301 0.1944
Brugia malayi jmjC domain containing protein 0.009 0.0052 0.0332
Schistosoma mansoni histone deacetylase hda2 0.0073 0.0039 0.0045
Plasmodium falciparum thioredoxin reductase 0.0024 0.0005 0.0062
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0144 0.0091 0.1218
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0024 0.0005 0.0005
Onchocerca volvulus 0.0062 0.0032 0.0208
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0077 0.0042 0.0271
Loa Loa (eye worm) hypothetical protein 0.0144 0.0091 0.0584
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.0264 0.0175 0.113
Onchocerca volvulus 0.0043 0.0019 0.012
Mycobacterium ulcerans aminopeptidase N PepN 0.0144 0.0091 0.009
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0001 0.0006
Brugia malayi hypothetical protein 0.1211 0.085 0.5476
Trichomonas vaginalis alpha-glucosidase, putative 0.0024 0.0005 0.0232
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0063
Schistosoma mansoni protein kinase 0.004 0.0016 0.0018
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0063
Brugia malayi hypothetical protein 0.0147 0.0092 0.0595
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0023 0.0004 0.0042
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0157 0.01 0.01
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.001 0.0063
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.003 0.0009 0.006
Echinococcus granulosus g protein coupled receptor 0.1211 0.085 0.5478
Echinococcus granulosus ferritin 0.002 0.0002 0.001
Loa Loa (eye worm) sugar transporter 0.0031 0.001 0.0063
Schistosoma mansoni opsin-like receptor 0.1211 0.085 0.0973
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.1211 0.085 0.5478
Schistosoma mansoni histone deacetylase 1 2 3 0.0034 0.0012 0.0013
Brugia malayi Zinc carboxypeptidase family protein 0.0076 0.0042 0.0268
Brugia malayi hypothetical protein 0.1211 0.085 0.5476
Onchocerca volvulus Alhambra homolog 0.0031 0.001 0.0065
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0846 0.0589 0.3799
Brugia malayi G-protein coupled receptor 0.1211 0.085 0.5476
Trypanosoma cruzi hexose transporter 0.0068 0.0036 0.048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0206 0.0135 0.6668
Giardia lamblia DINP protein human, muc B family 0.0024 0.0005 0.002
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0281 0.0188 0.121
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0127 0.0078 0.0078
Brugia malayi Zinc carboxypeptidase family protein 0.0076 0.0042 0.0268
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0144 0.0091 0.0583
Mycobacterium ulcerans ion antiporter, NhaP 0.005 0.0024 0.0023
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0127 0.0078 0.1056
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0078 0.0043 0.0278
Entamoeba histolytica hypothetical protein 0.0019 0.0001 0.0029
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.1211 0.085 0.0973
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0144 0.0091 0.1218
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0024 0.0005 0.0062
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0541 0.0373 0.0373
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0018
Echinococcus multilocularis lysosomal alpha glucosidase 0.0108 0.0065 0.0416
Echinococcus granulosus 7TM GPCR rhodopsin 0.1211 0.085 0.5478
Brugia malayi major facilitator superfamily protein 0.0031 0.001 0.0063
Plasmodium vivax thioredoxin reductase, putative 0.0069 0.0037 0.0596
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1211 0.085 0.0973
Loa Loa (eye worm) sodium/hydrogen exchanger 0.0264 0.0175 0.113
Schistosoma mansoni sex comb on midleg homolog 0.0066 0.0035 0.0039
Leishmania major squalene synthase, putative 0.1051 0.0736 1
Brugia malayi MBOAT family protein 0.0019 0.0001 0.0007
Mycobacterium tuberculosis Probable oxidoreductase 0.0175 0.0112 0.0112
Trichomonas vaginalis histone deacetylase, putative 0.0078 0.0044 0.2154
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0075 0.0041 0.0264
Loa Loa (eye worm) hypothetical protein 0.0385 0.0262 0.1686
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.002 0.0002 0.0002
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.003 0.0009 0.0061
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0075 0.0041 0.0265
Toxoplasma gondii histone deacetylase HDAC2 0.0078 0.0044 0.0725
Schistosoma mansoni lozenge 0.0023 0.0004 0.0005
Onchocerca volvulus 0.0059 0.003 0.0191
Echinococcus granulosus cytochrome P450 2K1 0.0127 0.0078 0.0505
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.0081 0.109
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0013 0.0159
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0213 0.0139 0.0897
Loa Loa (eye worm) hypothetical protein 0.0144 0.0091 0.0584
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0001 0.0001
Loa Loa (eye worm) aminopeptidase N 0.0281 0.0188 0.121
Trypanosoma cruzi histone deacetylase, putative 0.0034 0.0012 0.0146
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.01
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0028 0.0008 0.0086
Echinococcus granulosus neuropeptide Y receptor 0.1211 0.085 0.5478
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0056 0.0028 0.0028
Echinococcus granulosus biogenic amine 5HT receptor 0.1211 0.085 0.5478
Trypanosoma cruzi Carboxypeptidase-like protein 0.0076 0.0042 0.0552
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0085 0.0048 0.0055
Trypanosoma brucei aminopeptidase, putative 0.0085 0.0048 0.0642
Echinococcus granulosus glycine receptor subunit alpha 1 0.0846 0.0589 0.3799
Schistosoma mansoni hypothetical protein 0.1211 0.085 0.0973
Echinococcus granulosus tm gpcr rhodopsin 0.1211 0.085 0.5478
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0441 0.0301 0.1943
Onchocerca volvulus 0.0031 0.001 0.0063
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0181 0.0117 0.0751
Loa Loa (eye worm) zinc carboxypeptidase 0.0076 0.0042 0.0268
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.0208
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0104 0.0062 0.0398
Mycobacterium leprae Probable polyketide synthase Pks1 0.006 0.003 0.003
Schistosoma mansoni hypothetical protein 0.1211 0.085 0.0973
Echinococcus granulosus leukotriene A 4 hydrolase 0.0665 0.0461 0.2971
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0076 0.0042 0.2056
Brugia malayi Pre-SET motif family protein 0.0034 0.0012 0.0079
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0281 0.0188 0.121
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1211 0.085 0.0973
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0028 0.0008 0.0008
Brugia malayi ImpB/MucB/SamB family protein 0.003 0.0009 0.0058
Loa Loa (eye worm) hypothetical protein 0.0076 0.0042 0.0268
Loa Loa (eye worm) hypothetical protein 0.0461 0.0316 0.2033
Loa Loa (eye worm) hypothetical protein 0.0157 0.0099 0.0641
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0157 0.01 0.01
Echinococcus granulosus o acyltransferase membrane bound domain 0.0019 0.0001 0.0006
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.0081 0.0081
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0001 0.0005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0004 0.0005
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0127 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0157 0.01 0.01
Echinococcus granulosus glutamate receptor 2 0.0181 0.0117 0.0751
Schistosoma mansoni neuropeptide receptor 0.1211 0.085 0.0973
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0373 0.0253 0.1631
Plasmodium falciparum cysteine repeat modular protein 1 0.0062 0.0032 0.0514
Brugia malayi Matrixin family protein 0.0021 0.0003 0.0018
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0373 0.0253 0.1631
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.006 0.003 0.003
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0024 0.0005 0.0051
Loa Loa (eye worm) hypothetical protein 0.0076 0.0042 0.0268
Onchocerca volvulus Neuropeptide F receptor homolog 0.1211 0.085 0.5478
Loa Loa (eye worm) MBOAT family protein 0.0019 0.0001 0.0007
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0041 0.0017 0.0017
Brugia malayi nuclear receptor NHR-88 0.0019 0.0001 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1211 0.085 0.0973
Echinococcus granulosus glutamate NMDA receptor subunit 0.0354 0.024 0.1544
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0031 0.001 0.0062
Echinococcus multilocularis rhodopsin orphan GPCR 0.1211 0.085 0.5478
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.0208
Schistosoma mansoni glutamate receptor kainate 0.016 0.0102 0.0116
Trypanosoma brucei glucose transporter, putative 0.0068 0.0036 0.0482
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0027 0.0007 0.0343
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0024 0.0005 0.0232
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.0264 0.0175 0.1131
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0846 0.0589 0.3799
Trichomonas vaginalis N-myristoyl transferase, putative 0.0043 0.0019 0.0913
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0206 0.0135 0.6668
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0057 0.0028 0.0182
Schistosoma mansoni tyrosine kinase 0.0076 0.0042 0.0047
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.1211 0.085 0.0973
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0018 0 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0001 0.0005
Brugia malayi Integrin alpha pat-2 precursor 0.0099 0.0058 0.0376
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0127 0.0078 0.0078
Echinococcus multilocularis nmda type glutamate receptor 0.0181 0.0116 0.0749
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1211 0.085 0.5476
Echinococcus granulosus biogenic amine 5HT receptor 0.1211 0.085 0.5478
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Schistosoma mansoni tyrosine kinase 0.0047 0.0021 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0007
Mycobacterium ulcerans polyketide synthase Pks9 0.0037 0.0014 0.0014
Toxoplasma gondii kringle domain-containing protein 0.0062 0.0032 0.0531
Loa Loa (eye worm) hypothetical protein 0.0373 0.0253 0.1631
Schistosoma mansoni hypothetical protein 0.0021 0.0003 0.0003
Echinococcus multilocularis fmrfamide receptor 0.1211 0.085 0.5478
Echinococcus multilocularis dual specificity testis specific protein kinase 0.004 0.0016 0.0103
Brugia malayi Receptor family ligand binding region containing protein 0.0023 0.0004 0.0029
Echinococcus multilocularis SAM and MBT domain containing protein 0.0066 0.0035 0.0222
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1871 0.1319 0.8503
Schistosoma mansoni glucose transporter 0.0031 0.001 0.0011
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0263 0.0175 0.1125
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0012 0.0014
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.01 0.0059 0.0787
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0076 0.0042 0.0552
Toxoplasma gondii aspartyl protease ASP3 0.0023 0.0004 0.0063
Schistosoma mansoni jumonji/arid domain-containing protein 0.009 0.0052 0.0059
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0028 0.0008 0.0044
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0023 0.0004 0.0065
Loa Loa (eye worm) hypothetical protein 0.0846 0.0589 0.3799
Echinococcus granulosus neuropeptides capa receptor 0.1211 0.085 0.5478
Echinococcus multilocularis nmda type glutamate receptor 0.0254 0.0169 0.1086
Brugia malayi polk-prov protein 0.0027 0.0007 0.0043
Echinococcus multilocularis histone acetyltransferase MYST2 0.0075 0.0041 0.0264
Loa Loa (eye worm) hypothetical protein 0.0076 0.0042 0.0268
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0373 0.0253 0.029
Loa Loa (eye worm) sugar transporter 0.022 0.0144 0.093
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0063
Echinococcus granulosus JmjC domain containing protein 4 0.0023 0.0004 0.0024
Echinococcus granulosus epidermal growth factor receptor 0.0078 0.0043 0.0278
Loa Loa (eye worm) mbt repeat family protein 0.0066 0.0035 0.0223
Echinococcus granulosus histone deacetylase 6 0.0071 0.0038 0.0244
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0144 0.0091 0.4481
Echinococcus multilocularis Squalene phytoene synthase 0.0328 0.0221 0.1423
Echinococcus multilocularis mitochondrial sodium:hydrogen exchanger 9B2 0.005 0.0024 0.0151
Entamoeba histolytica aminopeptidase, putative 0.0281 0.0188 0.5949
Loa Loa (eye worm) jmjC domain-containing protein 0.0023 0.0004 0.0025
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0001 0.0006
Echinococcus granulosus dual specificity testis-specific protein kinase 0.004 0.0016 0.0103
Echinococcus multilocularis orexin receptor type 2 0.1211 0.085 0.5478
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Echinococcus multilocularis phd:f box containing protein 0.0023 0.0004 0.0024
Brugia malayi Sodium:neurotransmitter symporter family protein 0.2197 0.1551 0.9996
Schistosoma mansoni amine GPCR 1.2293 0.8735 1
Plasmodium vivax SET domain protein, putative 0.0034 0.0012 0.0186
Brugia malayi diacylglycerol acyltransferase 0.0019 0.0001 0.0007
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0373 0.0253 0.1631
Plasmodium vivax hypothetical protein, conserved 0.0031 0.001 0.0151
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0001 0.0005
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.001 0.0012
Echinococcus multilocularis solute carrier family 22 0.0031 0.001 0.0062
Brugia malayi Protein kinase domain containing protein 0.0135 0.0084 0.0542
Schistosoma mansoni acetylcholine receptor subunit beta 0.0385 0.0262 0.0299
Echinococcus multilocularis fmrfamide receptor 0.1211 0.085 0.5478
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0081 0.4016
Toxoplasma gondii facilitative glucose transporter GT1 0.022 0.0144 0.2399
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0066 0.0035 0.0224
Trypanosoma brucei glucose transporter, putative 0.0068 0.0036 0.0482
Loa Loa (eye worm) hypothetical protein 0.0461 0.0316 0.2033
Trypanosoma brucei Aminopeptidase M1, putative 0.0281 0.0188 0.2543
Echinococcus granulosus dnaJ subfamily B 0.0327 0.0221 0.1422
Schistosoma mansoni SET domain protein 0.0018 0.0001 0.0001
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0373 0.0253 0.1631
Echinococcus granulosus neuropeptide Y receptor 0.1211 0.085 0.5478
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0001 0.0005
Schistosoma mansoni protein kinase 0.004 0.0016 0.0018
Trypanosoma brucei glucose transporter, putative 0.0068 0.0036 0.0482
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0085 0.0048 0.0309
Trypanosoma cruzi histone deacetylase 1, putative 0.0078 0.0044 0.0579
Trichomonas vaginalis glucosylceramidase, putative 0.0147 0.0092 0.4574
Trypanosoma brucei sugar transporter, putative 0.0031 0.001 0.0121
Toxoplasma gondii histone deacetylase HDAC5 0.0034 0.0012 0.0196
Trichomonas vaginalis sugar transporter, putative 0.0031 0.001 0.0477
Onchocerca volvulus 0.0846 0.0589 0.38
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.003 0.0009 0.006
Mycobacterium ulcerans histidinol dehydrogenase 1.4071 1 1
Schistosoma mansoni jumonji domain containing protein 0.0023 0.0004 0.0004
Echinococcus multilocularis 0.0044 0.0019 0.0122
Onchocerca volvulus 0.0373 0.0253 0.1632
Brugia malayi Zinc carboxypeptidase family protein 0.0076 0.0042 0.0268
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0328 0.0221 0.0221
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0541 0.0373 0.0373
Onchocerca volvulus 0.0031 0.001 0.0063
Trypanosoma brucei Aminopeptidase M1, putative 0.0281 0.0188 0.2543
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0065
Plasmodium falciparum transporter, putative 0.0373 0.0253 0.4199
Brugia malayi Serotonin receptor 0.1211 0.085 0.5476
Schistosoma mansoni phosphatidylserine receptor 0.0023 0.0004 0.0004
Schistosoma mansoni biogenic amine (5HT) receptor 0.1211 0.085 0.0973
Loa Loa (eye worm) hypothetical protein 0.1211 0.085 0.5476
Onchocerca volvulus 0.1211 0.085 0.5478
Loa Loa (eye worm) hypothetical protein 0.0062 0.0032 0.0206
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0846 0.0589 0.3799
Brugia malayi Matrixin family protein 0.0021 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0006
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0029 0.0008 0.0053
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0063
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0846 0.0589 0.0675
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0017 0.0109
Loa Loa (eye worm) acyl carrier protein 0.0026 0.0006 0.004
Echinococcus multilocularis g-protein coupled receptor 0.1211 0.085 0.5478
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0264 0.0175 0.113
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0085 0.0048 0.0639
Chlamydia trachomatis cytosol aminopeptidase 0.0541 0.0373 1
Echinococcus multilocularis ferritin 0.002 0.0002 0.001
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0035 0.0013 0.0081
Trypanosoma brucei squalene synthase, putative 0.1051 0.0736 1
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0019 0.0001 0.0006
Brugia malayi sulfakinin receptor protein 0.2198 0.1552 1
Schistosoma mansoni ferritin light chain 0.002 0.0002 0.0002
Schistosoma mansoni aminopeptidase A (M01 family) 0.0144 0.0091 0.0103
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0373 0.0253 0.1631
Brugia malayi Calcitonin receptor-like protein seb-1 0.0067 0.0035 0.0228
Brugia malayi steroid hormone receptor 0.0019 0.0001 0.0006
Leishmania major glucose transporter, lmgt2 0.0068 0.0036 0.048
Schistosoma mansoni ATP-binding cassette transporter 0.016 0.0102 0.0116
Schistosoma mansoni tyrosine kinase 0.0047 0.0021 0.0024
Onchocerca volvulus Matrilysin homolog 0.0021 0.0003 0.0018
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.2107 0.1487 0.9585
Loa Loa (eye worm) histone deacetylase 11 0.0034 0.0012 0.0076
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0127 0.0078 0.0078
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1211 0.085 0.0973
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0019 0.0121
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0062 0.0032 0.042
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0137 0.0085 0.0547
Schistosoma mansoni glutamate receptor AMPA 0.016 0.0102 0.0116
Onchocerca volvulus 0.0385 0.0262 0.1687
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0846 0.0589 0.3799
Echinococcus granulosus glycine receptor subunit alpha 1 0.0846 0.0589 0.3799
Echinococcus granulosus allatostatin A receptor 0.1211 0.085 0.5478
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0016 0.0205
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0013 0.0637
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.0001
Toxoplasma gondii aminopeptidase N, putative 0.0862 0.0601 1
Loa Loa (eye worm) hypothetical protein 0.2197 0.1551 0.9996
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.0264 0.0175 0.113
Loa Loa (eye worm) glutamate receptor 1 0.016 0.0102 0.0655
Leishmania major trypanothione reductase 0.0069 0.0037 0.0487
Echinococcus multilocularis neutral alpha glucosidase AB 0.0024 0.0005 0.003
Echinococcus multilocularis NMDA receptor 0.0066 0.0035 0.0224
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0013 0.0199
Loa Loa (eye worm) hypothetical protein 0.0137 0.0085 0.0548
Loa Loa (eye worm) TATA binding protein associated factor 0.0144 0.0091 0.0584
Schistosoma mansoni tyrosine kinase 0.0076 0.0042 0.0047
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.2107 0.1487 0.9582
Schistosoma mansoni amine GPCR 0.1211 0.085 0.0973
Brugia malayi Melatonin receptor type 1A 0.1211 0.085 0.5476
Echinococcus multilocularis sex peptide receptor 0.1211 0.085 0.5478
Onchocerca volvulus 0.0846 0.0589 0.38
Schistosoma mansoni glutamate receptor NMDA 0.0354 0.024 0.0274
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0001 0.0001
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0076 0.0042 0.216
Toxoplasma gondii NADPH-glutathione reductase 0.0024 0.0005 0.0079
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0127 0.0078 0.0078
Onchocerca volvulus 0.0373 0.0253 0.1632
Mycobacterium ulcerans Type I modular polyketide synthase 0.0056 0.0028 0.0028
Schistosoma mansoni glucose transport protein 0.022 0.0144 0.0165
Loa Loa (eye worm) sodium/hydrogen exchanger 3 family protein 0.0264 0.0175 0.113
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0001 0.0005
Schistosoma mansoni amine GPCR 0.1211 0.085 0.0973
Onchocerca volvulus 0.1211 0.085 0.5478
Loa Loa (eye worm) hypothetical protein 0.0046 0.002 0.0131
Echinococcus multilocularis biogenic amine (5HT) receptor 0.1211 0.085 0.5478
Mycobacterium ulcerans bacterioferritin BfrB 0.002 0.0002 0.0002
Mycobacterium ulcerans polyketide synthase 0.0056 0.0028 0.0028
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.003 0.0009 0.0114
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0058
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0373 0.0253 0.1631
Trypanosoma brucei N-myristoyltransferase 0.0043 0.0019 0.0241
Echinococcus granulosus leucyl aminopeptidase 0.0085 0.0048 0.0309
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.003 0.0009 0.0011
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.001 0.0065
Echinococcus granulosus glutamate receptor 2 0.0115 0.007 0.0447

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) TP_TRANSPORTER: inhibition of Cephradine uptake (Cephradine: 1000 uM, Bestatin: 10000 uM) in PEPT1-expressing LLC-PK1 cells ChEMBL. 9190878
Activity (ADMET) Substrates of transporters of clinical importance in the absorption and disposition of drugs, PEPT1 ChEMBL. 20190787
Activity (functional) TP_TRANSPORTER: uptake in Xenopus laevis oocytes ChEMBL. 8639691
Activity (ADMET) Substrates of transporters of clinical importance in the absorption and disposition of drugs, PEPT2 ChEMBL. 20190787
Activity (functional) TP_TRANSPORTER: inhibition of Ceftibuten uptake (Ceftibuten: 1000 uM, Bestatin: 10000 uM) in PEPT1-expressing LLC-PK1 cells ChEMBL. 9190878
Activity (functional) TP_TRANSPORTER: inhibition of Ceftibuten uptake (Ceftibuten: 1000 uM, Bestatin: 10000 uM) in Xenopus laevis oocytes ChEMBL. 8531138
Activity (functional) TP_TRANSPORTER: uptake in PEPT1-expressing LLC-PK1 cells ChEMBL. 9190878
Activity (functional) TP_TRANSPORTER: inhibition of Cephradine uptake (Cephradine: 3000 uM, Bestatin: 10000 uM) in Xenopus laevis oocytes ChEMBL. 8531138
Activity (functional) Antimalarial activity as DNA content of ring stage Plasmodium falciparum 3D7 in medium + isoleucine by flow cytometry ChEMBL. 17895246
Activity (functional) Antimalarial activity as DNA content of ring stage Plasmodium falciparum 3D7 in medium with all amino acids by flow cytometry ChEMBL. 17895246
Activity (functional) > 10 % Cytotoxicity against human PANC1 cells assessed as cell growth inhibition after 72 hrs by XTT assay ChEMBL. 20347318
Activity (functional) > 10 % Cytotoxicity against human HT1080 cells assessed as cell growth inhibition after 72 hrs by XTT assay ChEMBL. 20347318
Activity (functional) = 60.25 % Antimetastatic activity in mouse H22 cells xenografted in mouse assessed as reduction of metastasized nodes at 50 mg/kg, po administered 6 days per week for 2 weeks measured after 1 day last post dose ChEMBL. 19683842
Change (functional) = -3 % Analgesic response measured as percentage change in reaction time (dose 25 ug given intracervically) after 60 min in mice ChEMBL. 1347791
Change (functional) = -3 % Analgesic response measured as percentage change in reaction time (dose 25 ug given intracervically) after 60 min in mice ChEMBL. 1347791
Change (functional) = 3 % Analgesic response measured as percentage change in reaction time (dose 25 ug given intracervically) after 30 min in mice ChEMBL. 1347791
Change (functional) = 3 % Analgesic response measured as percentage change in reaction time (dose 25 ug given intracervically) after 30 min in mice ChEMBL. 1347791
Change (functional) = 11 % Analgesic response measured as percentage change in reaction time (dose 100 ug given intracervically) after 5 min in mice ChEMBL. 1347791
Change (functional) = 11 % Analgesic response measured as percentage change in reaction time (dose 100 ug given intracervically) after 5 min in mice ChEMBL. 1347791
Change (functional) = 26 % Analgesic response measured as percentage change in reaction time (dose 25 ug given intracervically) after 5 min in mice ChEMBL. 1347791
Change (functional) = 26 % Analgesic response measured as percentage change in reaction time (dose 25 ug given intracervically) after 5 min in mice ChEMBL. 1347791
Change (functional) = 41 % Analgesic response measured as percentage change in reaction time (dose 100 ug given intracervically) after 30 min in mice ChEMBL. 1347791
Change (functional) = 41 % Analgesic response measured as percentage change in reaction time (dose 100 ug given intracervically) after 30 min in mice ChEMBL. 1347791
Change (functional) = 59 % Analgesic response measured as percentage change in reaction time (dose 100 ug given intracervically) after 60 min in mice ChEMBL. 1347791
Change (functional) = 59 % Analgesic response measured as percentage change in reaction time (dose 100 ug given intracervically) after 60 min in mice ChEMBL. 1347791
Cytotoxicity (functional) > 40 % In vitro cytotoxicity towards U937 cell growth was evaluated after 3 days of incubation (10e-4 M) ChEMBL. 12930151
Cytotoxicity (functional) > 40 % In vitro cytotoxicity towards U937 cell growth was evaluated after 3 days of incubation (10e-4 M) ChEMBL. 12930151
Delta Tm (binding) = 5.1 degrees C Binding affinity to human C-terminal His6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H assessed as change in melting temperature at 500 uM by sypro orange dye based differential scanning fluorimetric analysis LITERATURE. 27651294
Delta Tm (binding) = 5.2 degrees C Binding affinity to human C-terminal His6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H assessed as change in melting temperature at 1 mM by circular dichroism spectroscopic analysis LITERATURE. 27651294
EC50 (functional) Antimalarial activity against Plasmodium falciparum D10 clone ChEMBL. 17088482
EC50 (functional) Antimalarial activity against Plasmodium falciparum FAC8 clone ChEMBL. 17088482
EC50 (functional) 0 Antimalarial activity against Plasmodium falciparum D10 clone ChEMBL. 17088482
EC50 (functional) 0 Antimalarial activity against Plasmodium falciparum FAC8 clone ChEMBL. 17088482
EC50 (functional) = 0.9 uM Antimalarial activity as inhibition of Plasmodium falciparum 3D7 replication in medium + isoleucine after 65 hrs ChEMBL. 17895246
EC50 (functional) = 1.8 uM Antimalarial activity as inhibition of Plasmodium falciparum 3D7 replication in medium with all amino acids after 65 hrs ChEMBL. 17895246
EC50 (functional) = 5.1 uM Antimalarial activity against Plasmodium falciparum Dd2 clone ChEMBL. 17088482
EC50 (functional) = 5.1 uM Antimalarial activity against Plasmodium falciparum Dd2 clone ChEMBL. 17088482
I50 (binding) = 0.17 uM Inhibition of partially purified soluble aminopeptidase from rat brain ChEMBL. 3184127
IC50 (binding) DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) Inhibition of HDAC in human HeLa nuclear extract using Boc-Lys (acetyl)-AMC as fluorogenic substrate after 30 mins by spectrophotometry ChEMBL. 24755524
IC50 (binding) DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) ChEMBL. No reference
IC50 (binding) Inhibition of human full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to testing measured for 15 mins by fluorometric analysis ChEMBL. 26386821
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CXCR1 (IL-8A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) Inhibition of human full length MMP9 using Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to testing measured for 15 mins by fluorometric analysis ChEMBL. 26386821
IC50 (binding) DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) ChEMBL. No reference
IC50 (functional) = 0.92 mM Cytotoxicity against human HL60 cells after 48 hrs by MTT assay ChEMBL. 19299146
IC50 (functional) = 0.92 mM Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay ChEMBL. 19782572
IC50 (functional) = 1.13 mM Cytotoxicity against human HL60 cells expressing aminopeptidase N after 72 hrs by MTT assay ChEMBL. 20637634
IC50 (functional) = 1.34 mM Antiproliferative activity against human HL60 cells expressing high levels of APN after 48 hrs by MTT assay ChEMBL. 21802307
IC50 (functional) = 1.65 mM Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay ChEMBL. 19423354
IC50 (functional) = 1.65 mM Antiproliferative activity against human HL-60 cells after 48 hrs by MTT assay ChEMBL. 18996018
IC50 (functional) = 5.08 mM Antiproliferative activity against human MDA-MB-231 cells expressing low levels of APN after 48 hrs by MTT assay ChEMBL. 21802307
IC50 (functional) = 8.59 mM Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay ChEMBL. 20637634
IC50 (binding) = 5 nM Inhibitory activity against rabbit kidney aminopeptidase using 10 nM of [3H]-Leu-enkephalin as substrate ChEMBL. 3897541
IC50 (functional) = 8 nM Antimalarial activity against Plasmodium falciparum 3D7 infected in human O positive erythrocytes under low oxygen atmosphere after 72 hrs by spectrophotometric analysis ChEMBL. 23176597
IC50 (binding) = 2700 nM Inhibition of microsomal neural aminopeptidase in pig kidney ChEMBL. 17070058
IC50 (binding) = 2700 nM Inhibition of microsomal neural aminopeptidase in pig kidney ChEMBL. 17070058
IC50 (binding) = 0.05 ug ml-1 Inhibition of rat liver aminopeptidase B using 0.2 mM L-leucine-beta-naphthylamide by colorimetry ChEMBL. 850237
IC50 (binding) = 0.8100000000000002 ug ml-1 Inhibitory activity of the compound against aminopeptidase N assayed by the L-Ala-MCA method. ChEMBL. 9464355
IC50 (binding) > 100 ug ml-1 Inhibitory activity against Dipeptidyl-peptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line ChEMBL. 10098663
IC50 (binding) > 100 ug ml-1 Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line ChEMBL. 10098663
IC50 (binding) > 100 ug ml-1 Inhibitory activity of the compound against dipeptidyl peptidase IV (DPP- IV) ChEMBL. 9464355
IC50 (binding) uM Inhibition of human matrix metalloproteinase-14 expressed in Escherichia coli; ND=Not determined ChEMBL. 15582436
IC50 (binding) uM Inhibition of human matrix metalloproteinase-2 expressed in Sf9 insect cells; ND:Not determined ChEMBL. 15582436
IC50 (binding) 0 uM Inhibition of human matrix metalloproteinase-2 expressed in Sf9 insect cells; ND:Not determined ChEMBL. 15582436
IC50 (binding) 0 uM Inhibition of human matrix metalloproteinase-9 expressed in Sf9 insect cells; ND:Not determined ChEMBL. 15582436
IC50 (binding) 0 uM Inhibition of human matrix metalloproteinase-14 expressed in Escherichia coli; ND=Not determined ChEMBL. 15582436
IC50 (binding) = 0.0005 uM Inhibition of bovine lens cytosolic leucine aminopeptidase by Dixon plot analysis ChEMBL. 21292493
IC50 (binding) = 0.284 uM Inhibitory activity of the compound against Plasmodium falciparum Zinc aminopeptidase ChEMBL. 12873488
IC50 (binding) = 0.3 uM Compound was evaluated for its inhibitory potency against purified membrane bound rat brain APs ChEMBL. 1347791
IC50 (binding) = 0.3 uM Inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using L-arginine-7-amino-4-Methylcoumarine as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence assay LITERATURE. 27651294
IC50 (binding) = 0.5 uM Inhibition of aminopeptidase activity of human leukotriene A4 hydrolase by Dixon plot analysis ChEMBL. 21292493
IC50 (binding) = 1.3 uM Inhibition of pig kidney microsome aminopeptidase-N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by spectrophotometric analysis ChEMBL. 23510562
IC50 (binding) = 1.64 uM Inhibition of pig kidney microsomal APN using L-Leu-p-nitroanilide as substrate preincubated for 5 mins before substrate addition measured after 30 mins by spectrophotometry ChEMBL. 24755524
IC50 (binding) = 2.1 uM Inhibition of pig kidney aminopeptidase N ChEMBL. 18524593
IC50 (binding) = 2.1 uM Inhibition of pig kidney aminopeptidase N using Leu-AMC as substrate ChEMBL. 20347318
IC50 (binding) = 2.4 uM Inhibition of pig kidney microsomal aminopeptidase assessed as liberation of p-nitroanilide ChEMBL. 17433673
IC50 (binding) = 2.4 uM Inhibition of pig kidney microsomal aminopeptidase assessed as liberation of p-nitroanilide ChEMBL. 17433673
IC50 (binding) = 2.4 uM Inhibition of pig kidney microsomes aminopeptidase N preincubated for 30 mins ChEMBL. 19683842
IC50 (binding) = 2.4 uM Inhibition of aminopeptidase N ChEMBL. 20129718
IC50 (binding) = 2.5 uM Inhibition of aminopeptidase N (unknown origin) ChEMBL. 23860593
IC50 (binding) = 2.7 uM Inhibitory activity of the compound against mammalian Aminopeptidase N (APN) ChEMBL. 12873488
IC50 (binding) = 3 uM Inhibition of pig kidney microsomal Aminopeptidase N ChEMBL. 19423354
IC50 (binding) = 3.1 uM Inhibition of pig kidney microsomal APN ChEMBL. 19299146
IC50 (binding) = 3.1 uM Inhibition of pig kidney microsome aminopeptidase N by UV-visible spectrophotometer ChEMBL. 18996018
IC50 (functional) = 3.2 uM Antimalarial activity against Plasmodium falciparum 3D7 infected-erythrocytes after 72 hrs by SYBR green fluorescence method ChEMBL. 21366301
IC50 (binding) = 3.4 uM Inhibition of MMP2 after 30 mins ChEMBL. 17433673
IC50 (binding) = 3.4 uM Inhibition of MMP2 after 30 mins ChEMBL. 17433673
IC50 (binding) = 3.4 uM Inhibition of pig microsomal aminopeptidase N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by spectrophotometric analysis ChEMBL. 23453219
IC50 (binding) = 3.4 uM Inhibition of APN in porcine kidney microsomes preincubated for 5 mins before L-leu-p-nitroanilide substrate addition for 30 mins by plate reader analysis ChEMBL. 26629857
IC50 (binding) = 3.5 uM Inhibition of human aminopeptidase N by Dixon plot analysis ChEMBL. 21292493
IC50 (binding) = 3.6 uM Inhibition of porcine kidney microsome APN assessed as L-Leu-p-nitroanilide hydrolysis ChEMBL. 19782572
IC50 (binding) = 3.7 uM Inhibition of pig kidney microsomal APN assessed as hydrolysis of L-Leu-p-nitroanilide after 1 hr by spectrophotometry ChEMBL. 21802307
IC50 (binding) = 3.8 uM Inhibition of aminopeptidase N in pig kidney microsome by spectrophotometry ChEMBL. 19454370
IC50 (binding) = 3.8 uM Inhibition of APN from pig kidney microsomes by spectrophotometry ChEMBL. 19969464
IC50 (binding) = 3.9 uM Inhibitory concentration against aminopeptidase N ChEMBL. 15582436
IC50 (binding) = 3.9 uM Inhibitory concentration against aminopeptidase N ChEMBL. 15582436
IC50 (binding) = 4 uM Inhibitory activity against Leukotriene A4 hydrolase from human leukocytes ChEMBL. No reference
IC50 (binding) = 4 uM Inhibitory activity against Leukotriene A4 hydrolase from human leukocytes ChEMBL. No reference
IC50 (binding) = 4 uM Inhibition of human recombinant leukotriene A4 hydrolase ChEMBL. 18674901
IC50 (binding) = 4.18 uM Inhibition of pig kidney microsome aminopeptidase N after 30 mins by UV-vis spectrophotometric analysis ChEMBL. 20637634
IC50 (binding) = 4.2 uM Inhibition of human LTA4H epoxide hydrolase activity using LTA4 as substrate incubated for 15 mins prior to substrate addition measured after 10 mins by ELISA ChEMBL. 23220644
IC50 (binding) = 5.55 uM Inhibition of pig kidney microsome aminopeptidase N using L-Leu-p-nitroanilide substrate ChEMBL. 21911297
IC50 (binding) = 5.58 uM Inhibition of pig microsomal aminopeptidase N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by spectrophotometric analysis ChEMBL. 23860593
IC50 (binding) = 5.87 uM Inhibition of porcine kidney microsomal APN after 10 mins at room temperature by spectrophotometry ChEMBL. 21194957
IC50 (binding) = 6 uM Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase B using L-lysine-beta napthylamide as substrate ChEMBL. 1347791
IC50 (binding) = 6 uM Inhibition of Aminopeptidase B in murine L-cells by Aoyagi method. ChEMBL. No reference
IC50 (binding) = 6 uM Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase B using L-lysine-beta napthylamide as substrate ChEMBL. 1347791
IC50 (binding) = 6.9 uM Inhibition of porcine kidney microsomal APN using L-Leu-para-nitroanilide as substrate incubated for 2 hrs prior to substrate addition measured after 30 mins by plate reader analysis ChEMBL. 26386821
IC50 (binding) = 8.1 uM Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VIS spectrophotometry ChEMBL. 22607877
IC50 (binding) = 8.1 uM Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV-Vis spectrophotometry ChEMBL. 23528299
IC50 (binding) = 8.5 uM Inhibition of pig kidney microsomes aminopeptidase N ChEMBL. 18571419
IC50 (binding) = 8.9 uM Inhibition of porcine kidney microsome aminopeptidase using L-Leu-p-nitroanilide as substrate after 30 mins ChEMBL. 22901392
IC50 (binding) = 9.1 uM Inhibition of APN in porcine kidney microsome assessed as inhibition of L-Leu-p-nitroanilide substrate hydrolysis incubated for 5 mins before substrate addition by UV-Vis spectrophotometric analysis ChEMBL. 24900417
IC50 (binding) = 9.5 uM Inhibition of MMP2 ChEMBL. 18571419
IC50 (binding) = 10.1 uM Inhibition of recombinant C-terminal His-tagged human LTA4H aminopeptidase activity expressed in Escherichia coli using L-alanine-4-nitro-anilide hydrochloride as substrate preincubated for 20 mins followed by substrate addition LITERATURE. 28065501
IC50 (binding) = 11.2 uM Inhibitory concentration against adipocyte-derived leucine aminopeptidase ChEMBL. 15582436
IC50 (binding) = 11.2 uM Inhibitory concentration against adipocyte-derived leucine aminopeptidase ChEMBL. 15582436
IC50 (binding) = 13.1 uM Inhibition of pig kidney microsomal aminopeptidase N after 30 mins by UV-VIS spectrophotometry ChEMBL. 19339187
IC50 (binding) = 13.1 uM Inhibition of pig kidney microsome aminopeptidase N by UV-visible spectrophotometer ChEMBL. 19329328
IC50 (binding) = 16 uM Inhibition of APN in human ES2 cell surface assessed as inhibition of L-Leu-p-nitroanilide substrate hydrolysis incubated for 5 mins before substrate addition by UV-Vis spectrophotometric analysis ChEMBL. 24900417
IC50 (binding) = 18.01 uM Inhibition of recombinant C-terminal His-tagged human LTA4H epoxide hydrolase activity expressed in Escherichia coli assessed as reduction in LTB4 production using LTA4 as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins by enzyme immunoassay LITERATURE. 28065501
IC50 (binding) = 19.4 uM Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase M using [3H]-Leu-enkephalin as substrate ChEMBL. 1347791
IC50 (binding) = 19.4 uM Inhibition of Aminopeptidase M. ChEMBL. No reference
IC50 (binding) = 19.4 uM Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase M using [3H]-Leu-enkephalin as substrate ChEMBL. 1347791
IC50 (binding) = 20.12 uM Inhibition of aminopeptidase N in human ES2 cells using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by spectrophotometric analysis ChEMBL. 23453219
IC50 (binding) = 20.12 uM Inhibition of APN in human ES2 cells preincubated for 5 mins before L-leu-p-nitroanilide substrate addition for 1 hr by photometry ChEMBL. 26629857
IC50 (binding) = 21.96 uM Inhibition of MMP2 ChEMBL. 18467109
IC50 (binding) = 22.89 uM Inhibition of APN in human HL60 cells assessed as hydrolysis of L-Leu-p-nitroanilide by spectrophotometry ChEMBL. 21802307
IC50 (binding) = 23.2 uM Inhibition of APN in mouse B16-BL6 cell surface assessed as inhibition of L-Leu-p-nitroanilide substrate hydrolysis incubated for 5 mins before substrate addition by UV-Vis spectrophotometric analysis ChEMBL. 24900417
IC50 (functional) = 29 uM Inhibitory activity of the compound against FcB1 parasite growth ChEMBL. 12873488
IC50 (binding) = 29.67 uM Inhibition of aminopeptidase N in human ES2 cells assessed as L-Leu-p-nitroanilide hydrolysis ChEMBL. 21911297
IC50 (binding) = 29.67 uM Inhibition of aminopeptidase-N in human ES2 cells using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by spectrophotometric analysis ChEMBL. 23510562
IC50 (binding) = 40 uM Inhibition of APN in human ES2 cell surface using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 1 hr by UV/VIS spectrophotometry ChEMBL. 22607877
IC50 (binding) = 40 uM Inhibition of APN in human ES-2 cells using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 1 hr by UV-Vis spectrophotometry ChEMBL. 23528299
IC50 (binding) = 40.5 uM Inhibition of MMP2 ChEMBL. 19339187
IC50 (binding) = 40.5 uM Inhibition of MMP2 by spectrophotometry ChEMBL. 19329328
IC50 (functional) = 50.6 uM Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay ChEMBL. 23510562
IC50 (binding) > 100 uM Inhibition of human nonpancreatic secretory phospholipase A2 using 1,2-dimyristoyl-sn-glycero-3-phosphocholine as substrate after 10 mins by spectrophotometric analysis ChEMBL. 23220644
IC50 (binding) > 100 uM Inhibition of HDAC1/HDAC3/HDAC5/HDAC8 in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as substrate incubated for 5 mins prior to substrate measured after 30 mins by spectrophotometric analysis ChEMBL. 23453219
IC50 (binding) > 100 uM Inhibition of MMP2 (unknown origin) using succinylated gelatin as substrate preincubated for 10 mins before substrate addition measured after 30 mins by spectrophotometry ChEMBL. 24755524
IC50 (binding) > 100 uM Inhibition of HDAC1/HDAC2 in human HeLa cells nuclear extract preincubated for 5 mins before Boc-Lys (acetyl)-AMC substrate addition for 30 mins by microplate reader analysis ChEMBL. 26629857
IC50 (binding) = 120.4 uM Inhibition of human MMP-2 after 30 mins by spectrophotometry ChEMBL. 21802307
IC50 (binding) = 156 uM Inhibition of recombinant MMP2 using succinylated gelatin as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by UV/VIS spectrophotometry ChEMBL. 22607877
IC50 (binding) = 156 uM Inhibition of recombinant MMP2 (unknown origin) using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 60 mins by UV-Vis spectrophotometry ChEMBL. 23528299
IC50 (binding) = 156.98 uM Inhibition of MMP2 after 30 mins ChEMBL. 20637634
IC50 (binding) = 160 uM Inhibition of aminopeptidase B (unknown origin) ChEMBL. 27096037
IC50 (binding) = 162 uM Inhibition of MMP2 ChEMBL. 18996018
IC50 (binding) = 162 uM Inhibition of MMP2 ChEMBL. 19454370
IC50 (binding) = 162 uM Inhibition of MMP2 ChEMBL. 19782572
IC50 (binding) = 163.48 uM Inhibition of MMP2 after 30 mins ChEMBL. 21911297
IC50 (functional) = 245 uM Cytotoxicity against human HL60 cells after 48 hrs by MTT assay ChEMBL. 19683842
IC50 (functional) = 245 uM Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay ChEMBL. 22206607
IC50 (binding) = 253.2 uM Inhibition of MMP2 by spectrophotometry ChEMBL. 19969464
IC50 (binding) = 276 uM Inhibition of recombinant MMP-2 using succinylated gelatin as substrate incubated for 10 mins before addition of substrate measured after 60 mins by UV-Vis spectrophotometric analysis ChEMBL. 24900417
IC50 (binding) > 324.3 uM Inhibitory activity against Dipeptidyl-peptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line ChEMBL. 10098663
IC50 (binding) > 471.6 uM Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line ChEMBL. 10098663
IC50 (functional) = 753.18 uM Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay ChEMBL. 21911297
IC50 (binding) > 1000 uM Inhibition of HDAC1/HDAC3/HDAC5/HDAC8 in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as substrate incubated for 5 mins prior to substrate measured after 30 mins by spectrophotometric analysis ChEMBL. 23860593
IC50 (functional) > 1000 uM Antiproliferative activity against human U937 cells after 48 hrs by MTT assay ChEMBL. 23453219
IC50 (ADMET) > 1000 umol/L Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by MTT assay ChEMBL. 22901392
IC50 (functional) > 1000 umol/L Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay ChEMBL. 22901392
Inhibition (binding) Inhibition of aminopeptidase in human HL60 cells ChEMBL. 22901392
Inhibition (binding) Inhibition of human full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate at 10 uM incubated for 2 hrs prior to testing measured for 15 mins by fluorometric analysis relative to control ChEMBL. 26386821
Inhibition (binding) Inhibition of HDAC1/2 in human HeLa cells using Boc-Lys (acetyl)-AMC as substrate at 10 uM incubated for 2 hrs prior to substrate addition measured after 30 mins by fluorescence assay relative to control ChEMBL. 26386821
Inhibition (binding) Inhibition of human full length MMP9 using Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate at 10 uM incubated for 2 hrs prior to testing measured for 15 mins by fluorometric analysis relative to control ChEMBL. 26386821
Inhibition (binding) Inhibition of aminopeptidase in human ES-2 cells ChEMBL. 22901392
Inhibition (binding) = 6 % Inhibition of leucyl aminopeptidase activity in Plasmodium falciparum 3D7 at 0.1 uM using Leu-AMC as a substrate by spectrophotometer in presence of 1 nM CoCl2 ChEMBL. 18458130
Inhibition (ADMET) = 10.9 % Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake at 20 uM by scintillation counting ChEMBL. 22541068
Inhibition (ADMET) = 20.7 % Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake at 20 uM incubated for 5 mins by scintillation counting ChEMBL. 22541068
Inhibition (binding) = 29 % Inhibition of alanyl aminopeptidase activity in Plasmodium falciparum 3D7 at 0.1 uM using Ala-AMC as a substrate by spectrophotometer ChEMBL. 18458130
Inhibition (ADMET) = 31.8 % Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake at 20 uM incubated for 5 mins by scintillation counting ChEMBL. 22541068
Inhibition (binding) = 33 % Inhibition of leucyl aminopeptidase activity in Plasmodium falciparum 3D7 at 0.1 uM using Leu-AMC as a substrate by spectrophotometer ChEMBL. 18458130
Inhibition (functional) = 45.37 % Antimetastatic activity against human H22 cells xenografted in mouse assessed as inhibition of metastasized nodes on lung surface dosed orally 6 days/week for 2 weeks ChEMBL. 22206607
Inhibition (binding) = 47 % Inhibition of leucyl aminopeptidase activity in Plasmodium falciparum 3D7 harboring tPfAP-M17 gene at 0.1 uM using Leu-AMC as a substrate by spectrophotometer in presence of 1 nM CoCl2 ChEMBL. 18458130
Inhibition (functional) = 75.9 % Antimetastasis activity against mouse H22 cells implanted in mouse assessed as inhibition of tumour growth at 80 mg/kg/day, po administered 6 days/week for 2 weeks ChEMBL. 26629857
Inhibition (binding) = 85 % In vitro inhibition of aminopeptidase N (APN) activity in intact U937 cells in presence of Ala-pNA and 10e-3 M concentration of compound ChEMBL. 12930151
Inhibition (binding) = 85 % In vitro inhibition of aminopeptidase N (APN) activity in intact U937 cells in presence of Ala-pNA and 10e-3 M concentration of compound ChEMBL. 12930151
Inhibition (binding) = 93 % Inhibition of leucyl aminopeptidase activity in Plasmodium falciparum 3D7 at 10 uM using Leu-AMC as a substrate by spectrophotometer in presence of 1 nM CoCl2 ChEMBL. 18458130
Inhibition (binding) = 97 % Inhibition of alanyl aminopeptidase activity in Plasmodium falciparum 3D7 at 10 uM using Ala-AMC as a substrate by spectrophotometer ChEMBL. 18458130
Inhibition (binding) = 98 % Inhibition of leucyl aminopeptidase activity in Plasmodium falciparum 3D7 at 10 uM using Leu-AMC as a substrate by spectrophotometer ChEMBL. 18458130
Kd (binding) = 2.05 uM Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 25 degC by ITC method LITERATURE. 27651294
Kd (binding) = 4.63 uM Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 15 degC by ITC method LITERATURE. 27651294
Kd (binding) = 5.15 uM Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 35 degC by ITC method LITERATURE. 27651294
Ki (binding) DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CXCR1 (IL-8A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) = 0.6 nM Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidney ChEMBL. 12801228
Ki (binding) = 14 nM Inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver ChEMBL. 2566685
Ki (binding) = 14 nM Inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver ChEMBL. 2566685
Ki (binding) = 20 nM Inhibition of leucine aminopeptidase ChEMBL. 2566685
Ki (binding) = 20 nM Inhibition of leucine aminopeptidase ChEMBL. 2566685
Ki (binding) = 190 nM Inhibition of Plasmodium falciparum recombinant M1-aminopeptidase expressed in Escherichia coli after 40 mins uisng fluorogenic substrate L-Leucyl-7-amido-40-methylcoumarin by fluorescence spectrophotometry ChEMBL. 21366301
Ki (binding) = 0.0005 uM Competitive inhibition of pig APN using L-leucine-p-nitroanilide as substrate by Dixon-plot analysis ChEMBL. 22796349
Ki (binding) = 0.0016 uM Inhibition of Aeromonas proteolytica leucyl aminopeptidase using L-leucine para-notroanilide as substrate assessed as release of para-nitroaniline by Dixon plot analysis ChEMBL. 24055078
Ki (binding) = 0.02 uM Inhibitory activity against Leucine aminopeptidase ChEMBL. 3184126
Ki (binding) = 0.02 uM Inhibitory activity against Leucine aminopeptidase ChEMBL. 3184126
Ki (binding) = 0.06 uM Inhibitory activity against aminopeptidase B ChEMBL. 3184126
Ki (binding) = 0.06 uM Inhibitory activity against aminopeptidase B ChEMBL. 3184126
Ki (binding) = 0.32 uM Competitive inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using varying levels of L-arginine-7-amino-4-Methylcoumarine as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence assay LITERATURE. 27651294
Ki (binding) = 0.5 uM Competitive inhibition of bovine LAPc using L-leucine-p-nitroanilide as substrate by Dixon-plot analysis ChEMBL. 22796349
Ki (binding) = 3.03 uM Inhibition of mouse APN ChEMBL. 24900417
Ki (binding) = 3.5 uM Inhibition of porcine kidney APN using L-leucine para-notroanilide as substrate assessed as release of para-nitroaniline by Dixon plot analysis ChEMBL. 24055078
Ki (binding) = 3.73 uM Inhibition of porcine kidney microsome aminopeptidase using L-Leu-p-nitroanilide as substrate by Dixon method ChEMBL. 22901392
Ki (binding) = 4.4 uM Inhibition of aminopeptidase M or membrane leucine aminopeptidase ChEMBL. 2566685
Ki (binding) = 4.4 uM Inhibition of aminopeptidase M or membrane leucine aminopeptidase ChEMBL. 2566685
Ki (binding) = 7.8 uM Inhibitory activity against Aminopeptidase M ChEMBL. 3184126
Ki (binding) = 7.8 uM Inhibitory activity against Aminopeptidase M ChEMBL. 3184126
Ki (functional) = 18 uM TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT2-expressing LLC-PK1 cells ChEMBL. 11007306
Ki (functional) = 1500 uM TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT1-expressing LLC-PK1 cells ChEMBL. 11007306
Potency (functional) 0.3981 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.3981 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588378, AID588380] ChEMBL. No reference
Potency (functional) 0.8492 uM PubChem BioAssay. qHTS screen for enhancers of Arylsulfatase A (ASA1): LOPAC Validation Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors: Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493163, AID504444, AID504648] ChEMBL. No reference
Potency (functional) 8.4368 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 8.4921 uM PUBCHEM_BIOASSAY: qHTS Validation Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: qHTS validation assay of beta-arrestin-biased ligands of beta2-adrenergic receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485386, AID492947, AID504448, AID504454, AID504459] ChEMBL. No reference
Potency (functional) 16.4816 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Cell Surface uPA Generation: Validation Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493178] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Ratio IC50 (binding) = 0.71 Ratio of IC50 for microsomal aminopeptidase to IC50 for MMP2 ChEMBL. 17433673
TGI (functional) = 45.37 % Antimetastatic activity against mouse H22 cells transplanted in mouse lung assessed as inhibition of tumor growth on the surface of lungs at 50 mg/kg/day, po for 6 days a week for 2 weeks ChEMBL. 20129718

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23 17088482

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from structural similarity (ECO:0000027) Leishmania major 23720  
Annotator: aaronjr@u.washington.edu Comment: Drug: 26305-03-3. chemical inhibition with known cysteine peptidase inhibitors leads to reduced enzyme activity in vitro; References: 17028008
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania major 23720  
Annotator: aaronjr@u.washington.edu Comment: Drug: 26305-03-3. chemical inhibition with known cysteine peptidase inhibitors leads to reduced enzyme activity in vitro; References: 17028008
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania donovani 26075  
Annotator: crowther@u.washington.edu Comment: Drug: 160470-73-5 (Apstatin); Drug: 96551-81-4 (Arphamenine A); Drug: DL-Thiorphan. chemical inhibitors reduce LAP activity References: 12006595
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania major 26075  
Annotator: crowther@u.washington.edu Comment: Drug: 160470-73-5 (Apstatin); Drug: 96551-81-4 (Arphamenine A); Drug: DL-Thiorphan. chemical inhibitors reduce LAP activity References: 12006595
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 26075  
Annotator: crowther@u.washington.edu Comment: Drug: 160470-73-5 (Apstatin); Drug: 96551-81-4 (Arphamenine A); Drug: DL-Thiorphan. chemical inhibitors reduce LAP activity References: 12006595
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium chabaudi 333  
Annotator: saralph@unimelb.edu.au Comment: 012/Mar/09 References: 12166515 9879894
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium falciparum 333  
Annotator: saralph@unimelb.edu.au Comment: 012/Mar/09 References: 12166515 9879894
response to drug (GO:0042493) decreased sensitivity toward (PATO:0001550) bloodstream stage (PLO:0040) inferred from over expression (ECO:0000120) Plasmodium falciparum 2770  
Annotator: saralph@unimelb.edu.au Comment: 012/Mar/09 References: 16286469
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium chabaudi 2770  
Annotator: saralph@unimelb.edu.au Comment: 012/Mar/09 References: 16286469 9694371
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium falciparum 2770  
Annotator: saralph@unimelb.edu.au Comment: 012/Mar/09 References: 16286469 9694371

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

59 literature references were collected for this gene.

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