Detailed information for compound 167724

Basic information

Technical information
  • TDR Targets ID: 167724
  • Name: 2,8-disubstituted dipyridodiazepinone 7
  • MW: 407.896 | Formula: C22H22ClN5O
  • H donors: 0 H acceptors: 3 LogP: 4.17 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1c2ncc(cc2c(=O)n(c2c1nc(Cl)cc2)C)CN(c1ccccc1)C
  • InChi: 1S/C22H22ClN5O/c1-4-28-20-17(22(29)27(3)18-10-11-19(23)25-21(18)28)12-15(13-24-20)14-26(2)16-8-6-5-7-9-16/h5-13H,4,14H2,1-3H3
  • InChiKey: LXYRIXWPXWAGJA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-(N-Methylphenylamino)methyl-2-chloro-5,11-dihydro-11-ethyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
  • AIDS070356
  • AIDS-070356

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii integrase-related Get druggable targets OG5_139608 All targets in OG5_139608
Trypanosoma congolense RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Trypanosoma brucei RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Schistosoma mansoni hypothetical protein Get druggable targets OG5_139608 All targets in OG5_139608
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis smad 0.0009 0.0026 0.0063
Brugia malayi CXXC zinc finger family protein 0.0029 0.0117 0.0864
Toxoplasma gondii cathepsin CPC1 0.0003 0.0003 0.0084
Schistosoma mansoni hypothetical protein 0.0034 0.0142 0.0429
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0004 0.0005 0.0005
Brugia malayi Cathepsin L-like precursor 0.0018 0.0071 0.0523
Echinococcus multilocularis flap endonuclease 1 0.0029 0.012 0.0291
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0005 0.0009 0.0611
Loa Loa (eye worm) hypothetical protein 0.0003 0.0003 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0083 0.0693
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0021 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0226
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0004 0.0004 0.0131
Brugia malayi Cathepsin L-like precursor 0.0018 0.0071 0.0523
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0017 0.0138
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0269 0.0816
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0031 0.0226
Echinococcus multilocularis microtubule associated protein 2 0.0725 0.3299 0.8008
Plasmodium vivax transportin, putative 0.0005 0.0012 0.0827
Echinococcus granulosus Protein Wnt-04 0.0014 0.0052 0.0158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0071 0.0594
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0003 0.0003 0.0021
Onchocerca volvulus 0.0018 0.0071 0.0506
Echinococcus granulosus cathepsin L 0.0009 0.003 0.0092
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0044 0.1439
Loa Loa (eye worm) aromatic L-amino acid decarboxylase 0.0012 0.004 0.0286
Loa Loa (eye worm) hypothetical protein 0.0148 0.0665 0.4804
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0017 0.0138
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0003 0.0003 0.0018
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0004 0.0005 0.0005
Echinococcus granulosus bloom syndrome protein 0.0023 0.0094 0.0285
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0014 0.0454
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0004 0.0004 0.0004
Brugia malayi RNase H family protein 0.0027 0.0109 0.0801
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0032 0.0238
Schistosoma mansoni hypothetical protein 0.0004 0.0005 0.0015
Entamoeba histolytica cysteine protease, putative 0.0009 0.003 0.2531
Echinococcus multilocularis sphingosine 1 phosphate lyase 1 0.0012 0.004 0.0096
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0004 0.0005 0.0005
Toxoplasma gondii cathepsin CPL 0.0018 0.0071 0.2397
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0003 0.0001 0.0006
Onchocerca volvulus 0.0018 0.0071 0.0506
Loa Loa (eye worm) hypothetical protein 0.0111 0.0495 0.3576
Echinococcus multilocularis cathepsin b 0.0003 0.0003 0.0006
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0026 0.0188
Echinococcus granulosus aromatic amino acid decarboxylase 0.0012 0.004 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0003 0.0003 0.0021
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0377
Brugia malayi MH1 domain containing protein 0.0009 0.0026 0.0192
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0013 0.0046 0.0141
Entamoeba histolytica HEAT repeat domain containing protein 0.0005 0.0012 0.0981
Plasmodium vivax importin-beta 2, putative 0.0029 0.0118 0.8301
Plasmodium vivax vivapain-2 0.0018 0.0071 0.5005
Brugia malayi MH1 domain containing protein 0.0005 0.0009 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0142 0.043
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0021 0.0083 0.0201
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0101 0.342
Echinococcus granulosus protein Wnt 1 0.0014 0.0052 0.0158
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0296 0.0296
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0004 0.0005 0.0005
Brugia malayi Neurabin protein 1 0.0013 0.0046 0.0342
Schistosoma mansoni DNA helicase recq1 0.001 0.0031 0.0095
Brugia malayi XPG I-region family protein 0.0006 0.0014 0.0103
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0025 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0003 0.0003 0.0021
Schistosoma mansoni microtubule-associated protein tau 0.0725 0.3299 1
Loa Loa (eye worm) ctsf protein 0.0018 0.0071 0.0513
Schistosoma mansoni hypothetical protein 0.0004 0.0004 0.0012
Echinococcus granulosus stromal interaction molecule 1 0.0013 0.0046 0.0141
Schistosoma mansoni smad1 5 8 and 0.0009 0.0026 0.0079
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0014 0.0454
Schistosoma mansoni myst-related protein 0.0003 0.0002 0.0007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0071 0.0594
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0003 0.0003 0.0008
Brugia malayi MH2 domain containing protein 0.0009 0.0026 0.0192
Schistosoma mansoni wnt related 0.0014 0.0052 0.0158
Mycobacterium ulcerans histidinol dehydrogenase 0.2193 1 1
Leishmania major cathepsin L-like protease 0.0018 0.0071 0.2312
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0071 0.5935
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0004 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0377
Echinococcus granulosus Smad4 0.0009 0.0026 0.0079
Trichomonas vaginalis flap endonuclease-1, putative 0.0006 0.0014 0.0117
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0003 0.0003 0.0176
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0059 0.0142
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0072 0.0217
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0004 0.0005 0.0164
Plasmodium falciparum endonuclease, putative 0.0003 0.0001 0.0101
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0071 0.0594
Entamoeba histolytica zinc finger protein, putative 0.0021 0.0083 0.6925
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0003 0.0003 0.0018
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0004 0.0004 0.0004
Leishmania major sphingosine 1-phosphate lyase 0.0012 0.004 0.1289
Schistosoma mansoni ran 0.0021 0.0083 0.0252
Trypanosoma brucei DNA repair protein RAD2, putative 0.0006 0.0014 0.0315
Echinococcus multilocularis snurportin 1 0.0306 0.1384 0.3359
Entamoeba histolytica cysteine protease, putative 0.0009 0.003 0.2531
Plasmodium falciparum serine repeat antigen 2 0.0003 0.0003 0.0209
Onchocerca volvulus Tankyrase homolog 0.0132 0.059 0.4331
Echinococcus granulosus flap endonuclease 1 0.0029 0.012 0.0363
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0003 0.0003 0.0021
Leishmania major cytochrome p450-like protein 0.0004 0.0005 0.0164
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0017 0.0138
Brugia malayi Aromatic-L-amino-acid decarboxylase 0.0012 0.004 0.0292
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0004 0.0005 0.0005
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0003 0.0003 0.0176
Brugia malayi Tnks protein 0.0146 0.0653 0.4805
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0031 0.0095
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0004 0.0005 0.0005
Mycobacterium leprae putative cytochrome p450 0.0004 0.0005 0.0005
Trypanosoma cruzi cysteine peptidase, putative 0.0009 0.003 0.0986
Entamoeba histolytica cysteine protease, putative 0.0009 0.003 0.2531
Schistosoma mansoni smad 0.0009 0.0026 0.0079
Plasmodium falciparum importin beta, putative 0.0029 0.0118 0.9845
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0004 0.0005 0.0005
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0203 0.0617
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0004 0.0004 0.003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0523
Echinococcus multilocularis pyridoxal dependent decarboxylase 0.0012 0.004 0.0096
Echinococcus multilocularis cathepsin L 0.0003 0.0003 0.0006
Schistosoma mansoni lip-related protein (liprin) alpha 0.0013 0.0046 0.0141
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0101 0.8469
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0083 0.6958
Schistosoma mansoni hypothetical protein 0.0407 0.1843 0.5587
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0003 0.0003 0.0021
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0025 0.0076
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0071 0.0594
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0003 0.0003 0.0081
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0004 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0034 0.0142 0.1023
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0003 0.0003 0.0176
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0004 0.0004 0.001
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0009 0.003 0.0986
Trichomonas vaginalis set domain proteins, putative 0.0265 0.1197 1
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0094 0.0693
Entamoeba histolytica cysteine protease, putative 0.0009 0.003 0.2531
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0029 0.0119 0.2685
Trypanosoma brucei exonuclease, putative 0.0006 0.0014 0.0315
Echinococcus multilocularis transportin 1 0.0005 0.0012 0.0028
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0004 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0003 0.0003 0.0024
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0101 0.7141
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0071 0.2312
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0059 0.0431
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0021 0.0083 0.0599
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0004 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0047 0.0203 0.147
Leishmania major GTP-binding protein, putative 0.0021 0.0083 0.2711
Loa Loa (eye worm) CYP4Cod1 0.0014 0.005 0.0359
Echinococcus granulosus snurportin 1 0.0306 0.1384 0.4195
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0296 0.0296
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0071 0.0594
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0004 0.0005 0.0005
Brugia malayi Cathepsin L-like precursor 0.0018 0.0071 0.0523
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0307 0.6926
Brugia malayi cathepsin F-like cysteine proteinase 0.0006 0.0015 0.0109
Brugia malayi Flap endonuclease-1 0.0029 0.012 0.0881
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0003 0.0003 0.0008
Trichomonas vaginalis ribonuclease H1, putative 0.0027 0.0109 0.0909
Brugia malayi Papain family cysteine protease containing protein 0.0003 0.0003 0.0018
Echinococcus multilocularis importin 5 0.0005 0.0012 0.0028
Schistosoma mansoni aldehyde dehydrogenase 0.0004 0.0004 0.0012
Schistosoma mansoni importin-beta 2 0.0005 0.0012 0.0036
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0003 0.0003 0.0209
Plasmodium falciparum cysteine proteinase falcipain 1 0.0009 0.003 0.2531
Schistosoma mansoni hypothetical protein 0.0013 0.0046 0.0141
Loa Loa (eye worm) hypothetical protein 0.0003 0.0003 0.0018
Onchocerca volvulus 0.0265 0.1198 0.8816
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.003 0.0092
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.012 0.2698
Loa Loa (eye worm) CWN-2 protein 0.0014 0.0052 0.0377
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0004 0.0004 0.0004
Echinococcus granulosus muscleblind protein 0.0148 0.0665 0.2015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0071 0.0594
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0.003 0.0092
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0233 0.0708
Onchocerca volvulus 0.0013 0.0046 0.0324
Brugia malayi WGR domain containing protein 0.0021 0.0083 0.061
Echinococcus multilocularis mothers against decapentaplegic 6 0.0004 0.0004 0.0011
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0296 1
Plasmodium vivax SET domain protein, putative 0.0034 0.0142 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0142 0.043
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0004 0.0004 0.0004
Treponema pallidum ribonuclease H (rnhA) 0.0027 0.0109 1
Loa Loa (eye worm) sphingosine-1-phosphate lyase 1 0.0012 0.004 0.0286
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0003 0.0003 0.0021
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0213 0.157
Echinococcus multilocularis liprin beta 1 0.0013 0.0046 0.0113
Brugia malayi Pre-SET motif family protein 0.0233 0.105 0.7733
Loa Loa (eye worm) Smad1 0.0009 0.0026 0.0188
Echinococcus multilocularis stromal interaction molecule 1 0.0013 0.0046 0.0113
Trypanosoma cruzi sphingosine 1-phosphate lyase, putative 0.0012 0.004 0.1289
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.012 0.3896
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0004 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.003 0.0253
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0004 0.0004 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0004 0.0005 0.0005
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0027 0.0109 1
Trypanosoma cruzi cruzipain precursor, putative 0.0006 0.0015 0.0481
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0004 0.0004 0.0004
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0031 0.0095
Brugia malayi Wnt-4 protein precursor 0.0014 0.0052 0.0384
Echinococcus multilocularis protein Wnt 1 0.0014 0.0052 0.0127
Trichomonas vaginalis helicase, putative 0.0006 0.0017 0.0138
Plasmodium falciparum transportin 0.0005 0.0012 0.0981
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0142 0.043
Loa Loa (eye worm) hypothetical protein 0.03 0.1358 0.9816
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0004 0.0004 0.0131
Giardia lamblia hypothetical protein 0.0006 0.0014 0.0978
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0071 0.0594
Schistosoma mansoni hypothetical protein 0.0306 0.1384 0.4195
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0017 0.0138
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0004 0.0004 0.0029
Loa Loa (eye worm) Wnt2 protein 0.0014 0.0052 0.0377
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.012 1
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0071 0.0215
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0071 0.5935
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0004 0.0004 0.0012
Echinococcus multilocularis cysteine protease 0.0018 0.0071 0.0172
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0059 0.0431
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0021 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0335
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0004 0.0004 0.0131
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0031 0.1053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0017 0.0138
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0004 0.0004 0.0131
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0004 0.0005 0.0005
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0013 0.0046 0.0335
Echinococcus granulosus ribonuclease H1 0.0027 0.0109 0.033
Plasmodium falciparum serine repeat antigen 9 0.0003 0.0003 0.0209
Echinococcus granulosus Sterile alpha motif SAM 0.0013 0.0046 0.0141
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0043 0.0318
Trichomonas vaginalis ran, putative 0.0021 0.0083 0.0696
Trichomonas vaginalis hypothetical protein 0.0005 0.0012 0.0098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0307 0.6926
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0233 0.1718
Echinococcus granulosus cathepsin l1 0.0018 0.0071 0.0215
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0213 0.157
Plasmodium falciparum exonuclease I, putative 0.0006 0.0014 0.1166
Loa Loa (eye worm) hypothetical protein 0.0148 0.0665 0.4804
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0377
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0003 0.0003 0.0021
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0059 0.0178
Loa Loa (eye worm) hypothetical protein 0.0029 0.0118 0.0852
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0004 0.0004 0.0004
Echinococcus granulosus cathepsin l1 0.0012 0.0043 0.0131
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0003 0.0003 0.0176
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.003 0.2531
Brugia malayi cytochrome P450 0.0004 0.0005 0.0037
Loa Loa (eye worm) hypothetical protein 0.0004 0.0004 0.0032
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0003 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0054 0.0233 0.1687
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0006 0.0014 0.0454
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0071 0.0594
Loa Loa (eye worm) histone methyltransferase 0.001 0.0033 0.0238
Schistosoma mansoni hypothetical protein 0.0016 0.0059 0.0178
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0101
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0004 0.0004 0.0029
Loa Loa (eye worm) cytochrome P450 family protein 0.0004 0.0005 0.0036
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0083 0.2711
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0004 0.0004 0.001
Giardia lamblia Ribonuclease H 0.0027 0.0109 0.9066
Echinococcus granulosus mothers against decapentaplegic 6 0.0004 0.0004 0.0013
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0004 0.0005 0.0005
Plasmodium vivax serine-repeat antigen (SERA) 0.0003 0.0003 0.0176
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.0279 0.9096
Trypanosoma cruzi cysteine proteinase, putative 0.0009 0.003 0.0986
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0296 0.0296
Leishmania major cathepsin L-like protease 0.007 0.0307 1
Loa Loa (eye worm) importin-beta domain-containing protein 0.0005 0.0012 0.0085
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0286
Loa Loa (eye worm) hypothetical protein 0.0016 0.0059 0.0423
Loa Loa (eye worm) MH1 domain-containing protein 0.0004 0.0004 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0071 0.0594
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0026 0.0079
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0038 0.0116
Plasmodium vivax serine-repeat antigen (SERA) 0.0003 0.0003 0.0176
Brugia malayi mbt repeat family protein 0.0047 0.0203 0.1498
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0004 0.0004 0.0336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0043 0.0361
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0031 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0071 0.0594
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0004 0.0004 0.0131
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0093 0.303
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0003 0.0003 0.0021
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0003 0.0003 0.0008
Toxoplasma gondii ribonuclease HI protein 0.0027 0.0109 0.3669
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0004 0.0004 0.0136
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.012 0.0865
Plasmodium falciparum DNA repair protein RAD2, putative 0.0006 0.0014 0.1166
Toxoplasma gondii cathepsin CPC2 0.0003 0.0003 0.0084
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0004 0.0004 0.001
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0004 0.0004 0.0131
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0014 0.005 0.005
Giardia lamblia Exonuclease 1 0.0006 0.0014 0.0978
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0335
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0059 0.0423
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.0307 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.0004 0.0029
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0004 0.0005 0.0005
Echinococcus granulosus liprin alpha 2 0.0013 0.0046 0.0141
Leishmania major cytochrome p450-like protein 0.0014 0.005 0.1617
Trichomonas vaginalis conserved hypothetical protein 0.0003 0.0001 0.0006
Plasmodium vivax exonuclease I, putative 0.0006 0.0014 0.0984
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0233 0.0567
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.105 0.7591
Loa Loa (eye worm) tnks protein 0.0134 0.06 0.4335
Brugia malayi Papain family cysteine protease containing protein 0.0003 0.0003 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0307 0.6926
Trichomonas vaginalis conserved hypothetical protein 0.0003 0.0003 0.0021
Schistosoma mansoni cpg binding protein 0.003 0.0125 0.0378
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0044 0.0369
Schistosoma mansoni hypothetical protein 0.0168 0.0756 0.2292
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0017 0.0138
Toxoplasma gondii cathepsin B 0.0003 0.0003 0.0084
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0004 0.0004 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0017 0.0138
Schistosoma mansoni wnt related 0.0014 0.0052 0.0158
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0004 0.0004 0.0136
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0081 0.6775
Trypanosoma cruzi Pyridoxal-dependent decarboxylase conserved domain containing protein, putative 0.0012 0.004 0.1289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0071 0.0594
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0203 0.0494
Loa Loa (eye worm) TDC-1 protein 0.0012 0.004 0.0286
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0203 0.0494
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0059 0.1976
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0118 0.0286
Schistosoma mansoni cpg binding protein 0.003 0.0125 0.0378
Echinococcus granulosus cathepsin b 0.0003 0.0003 0.0008
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0083 0.6894
Schistosoma mansoni hypothetical protein 0.0016 0.0059 0.0178
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0003 0.0003 0.0176
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0101 0.3299
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.012 0.3896
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0203 0.0617
Leishmania major ribonuclease H1, putative 0.0027 0.0109 0.354
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0377
Loa Loa (eye worm) hypothetical protein 0.0025 0.0101 0.0733
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0004 0.0004 0.0004
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0004 0.0004 0.0131
Schistosoma mansoni sphingosine phosphate lyase 0.0012 0.004 0.012
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.003 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0142 0.043
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0005 0.001 0.031
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0026 0.0063
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0017 0.0138
Trypanosoma brucei ribonuclease H1 0.0027 0.0109 0.2452
Treponema pallidum ATP-dependent DNA helicase 0.0005 0.001 0.0526
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0229
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0307 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0307 0.6926
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0017 0.0138
Trypanosoma brucei poly(adp-ribose) polymerase 0.0021 0.0083 0.1869
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0004 0.0004 0.003
Entamoeba histolytica recQ family DNA helicase 0.0005 0.001 0.0796
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0004 0.0004 0.0004
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0083 0.0602
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0004 0.0004 0.0091
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0107
Brugia malayi MH1 domain containing protein 0.0009 0.0026 0.0192
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0004 0.0004 0.0131
Schistosoma mansoni phenylalanine decarboxylase 0.0012 0.004 0.012
Loa Loa (eye worm) hypothetical protein 0.0005 0.0009 0.0062
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0003 0.0003 0.0008
Entamoeba histolytica cysteine protease, putative 0.0003 0.0003 0.0209
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0203 0.147
Schistosoma mansoni cathepsin B (C01 family) 0.0003 0.0003 0.0008
Mycobacterium ulcerans glutamate decarboxylase 0.0012 0.004 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0071 0.0594
Trichomonas vaginalis exonuclease%2C+putative 0.0006 0.0014 0.0117
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0004 0.0005 0.0005
Brugia malayi coiled-coil like protein 1 0.0013 0.0046 0.0342
Leishmania major cytochrome p450-like protein 0.0004 0.0005 0.0164
Entamoeba histolytica hypothetical protein 0.0003 0.0002 0.0198
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0006 0.0015 0.0109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0071 0.0594
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0083 0.0693
Echinococcus multilocularis WNT 0.0014 0.0052 0.0127
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0004 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0071 0.0513
Onchocerca volvulus 0.0012 0.0043 0.0301
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0093 0.0778
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0003 0.0003 0.0008
Entamoeba histolytica cysteine proteinase 1, putative 0.0009 0.003 0.2531
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0059 0.4186
Schistosoma mansoni wnt-5 0.0014 0.0052 0.0158
Entamoeba histolytica cysteine protease, putative 0.0009 0.003 0.2531
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0905 0.4119 1
Onchocerca volvulus 0.03 0.1358 1
Leishmania major cathepsin L-like protease 0.0018 0.0071 0.2312
Echinococcus granulosus dnaJ subfamily B 0.0407 0.1843 0.5587
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0004 0.0004 0.0004
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.056 0.4046
Brugia malayi hypothetical protein 0.03 0.1358 1
Brugia malayi Wnt-2 protein precursor 0.0014 0.0052 0.0384
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.084 0.2546
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0044 0.3694
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0071 0.0513
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0006 0.0014 0.0042
Schistosoma mansoni Smad4 0.0009 0.0026 0.0079
Echinococcus multilocularis muscleblind protein 1 0.0148 0.0665 0.1614
Entamoeba histolytica hypothetical protein 0.0021 0.0083 0.6925
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0025 0.0061
Onchocerca volvulus 0.0013 0.0046 0.0324
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0031 0.2449
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0004 0.0005 0.0005
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0004 0.0004 0.0131
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0004 0.0005 0.0005
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0005 0.0012 0.0265
Echinococcus multilocularis ribonuclease H1 0.0027 0.0109 0.0264
Entamoeba histolytica hypothetical protein 0.0021 0.0083 0.6925
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0094 0.0786
Toxoplasma gondii HEAT repeat-containing protein 0.0005 0.0012 0.0396
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0005 0.0012 0.0265
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0233 0.0708
Leishmania major cathepsin L-like protease 0.007 0.0307 1
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.003 0.0223
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0026 0.0063
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0006 0.0014 0.0471
Entamoeba histolytica s phingosine-1-phosphate lyase 1, putative 0.0012 0.004 0.3309
Schistosoma mansoni Smad4 0.0004 0.0004 0.0013
Echinococcus multilocularis mothers against decapentaplegic 2 0.0004 0.0004 0.0011
Onchocerca volvulus 0.0018 0.0071 0.0506
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0117 0.0848
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0307 0.6926
Schistosoma mansoni wnt related 0.0014 0.0052 0.0158
Schistosoma mansoni smad1 5 8 and 0.0009 0.0026 0.0079
Plasmodium vivax unspecified product 0.0009 0.003 0.2134
Echinococcus multilocularis tankyrase 0.0147 0.0658 0.1598
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0003 0.0003 0.0008
Brugia malayi cathepsin Z-like cysteine proteinase 0.0003 0.0003 0.0018
Trypanosoma brucei cytochrome P450, putative 0.0014 0.005 0.112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0009 0.003 0.0683
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0599
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0004 0.0004 0.0004
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0307 1
Brugia malayi fibroinase precursor 0.0003 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0003 0.0003 0.0018
Trypanosoma cruzi cysteine peptidase, putative 0.0006 0.0015 0.0481
Trichomonas vaginalis conserved hypothetical protein 0.0003 0.0001 0.0006
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.003 0.2531
Entamoeba histolytica cysteine protease, putative 0.0009 0.003 0.2531
Schistosoma mansoni Smad4 0.0004 0.0004 0.0013
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.003 0.2531
Echinococcus multilocularis muscleblind protein 0.0148 0.0665 0.1614
Brugia malayi glutamate decarboxylase putative 0.0012 0.004 0.0292
Entamoeba histolytica cysteine protease, putative 0.0003 0.0003 0.0209
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0004 0.0004 0.0136
Schistosoma mansoni hypothetical protein 0.01 0.0444 0.1345
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0003 0.0003 0.0176
Loa Loa (eye worm) wnt-4 protein 0.0014 0.0052 0.0377
Schistosoma mansoni phenylalanine decarboxylase 0.0012 0.004 0.012
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0003 0.0003 0.0081
Entamoeba histolytica Ran family GTPase 0.0021 0.0083 0.6958
Schistosoma mansoni hypothetical protein 0.0011 0.0038 0.0116
Brugia malayi SET domain containing protein 0.0003 0.0003 0.0021
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0003 0.0003 0.0008
Toxoplasma gondii preprocathepsin c precursor, putative 0.0003 0.0003 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0071 0.0594
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0017 0.0138
Entamoeba histolytica cysteine protease, putative 0.0009 0.003 0.2531
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0006 0.0014 0.0471
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0071 0.0594
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0003 0.0003 0.0021
Brugia malayi Pyridoxal-dependent decarboxylase conserved domain containing protein 0.0012 0.004 0.0292
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0059 0.0178
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0004 0.0005 0.0005
Entamoeba histolytica cysteine protease, putative 0.0003 0.0003 0.0209
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0017 0.0138
Entamoeba histolytica Flap nuclease, putative 0.0029 0.012 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0101 0.2285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0307 0.6926
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0004 0.0005 0.0005
Schistosoma mansoni aldehyde dehydrogenase 0.0004 0.0004 0.0012
Leishmania major importin beta-1 subunit, putative 0.0023 0.0093 0.303
Brugia malayi biogenic amine synthesis related protein 1 0.0012 0.004 0.0292
Loa Loa (eye worm) hypothetical protein 0.0003 0.0003 0.0018
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0004 0.0005 0.0005
Loa Loa (eye worm) aldehyde dehydrogenase 0.0004 0.0004 0.0029
Plasmodium falciparum serine repeat antigen 6 0.0003 0.0003 0.0209
Trypanosoma brucei ingi protein (ORF1) 0.0029 0.0119 0.2685
Schistosoma mansoni phosphoglucomutase 0.0027 0.0109 0.033
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.1843 0.4474
Onchocerca volvulus 0.0018 0.0071 0.0506
Plasmodium falciparum serine repeat antigen 7 0.0003 0.0003 0.0209
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0071 0.0594
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0203 0.0617
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0003 0.0003 0.0176
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0004 0.0004 0.0034
Brugia malayi glutamate decarboxylase, 67 kDa isoform 0.0012 0.004 0.0292
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0239 0.8079
Brugia malayi MH2 domain containing protein 0.0009 0.0026 0.0192
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0003 0.0003 0.0021
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0003 0.0003 0.0081
Brugia malayi wnt family protein 0.0014 0.0052 0.0384
Onchocerca volvulus Ribonuclease H1 homolog 0.0027 0.0109 0.0784
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0017 0.0138
Echinococcus granulosus mothers against decapentaplegic 2 0.0004 0.0004 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.003 0.0253
Entamoeba histolytica cysteine protease, putative 0.0009 0.003 0.2531
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0017 0.0138
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0004 0.0004 0.0091
Echinococcus granulosus Protein Wnt-5 0.0014 0.0052 0.0158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0307 0.6926
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0094 0.0786
Entamoeba histolytica recQ family helicase, putative 0.0005 0.0009 0.0724
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0004 0.0004 0.0131
Plasmodium falciparum flap endonuclease 1 0.0029 0.012 1
Brugia malayi wnt family protein 0.0014 0.0052 0.0384
Brugia malayi Cytochrome P450 family protein 0.0004 0.0005 0.0037
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0142 0.0345
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0083 0.0202
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0003 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0003 0.0003 0.0018
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0004 0.0005 0.0164
Echinococcus granulosus SAM domain containing protein 0.0013 0.0046 0.0141
Onchocerca volvulus 0.0047 0.0203 0.1482
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0071 0.0215
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0026 0.0079
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0013 0.0046 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.004 0.1289
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0003 0.0003 0.0008
Brugia malayi RNase H family protein 0.0027 0.0109 0.0801
Echinococcus granulosus GPCR family 2 0.0016 0.0059 0.0178
Echinococcus granulosus Protein Wnt-11b 0.0014 0.0052 0.0158
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0004 0.0005 0.0005
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0038 0.0093
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0004 0.0005 0.0005
Entamoeba histolytica exonuclease, putative 0.0006 0.0014 0.1166
Schistosoma mansoni phosphoglucomutase 0.0027 0.0109 0.033
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0044 0.1439
Brugia malayi MH1 domain containing protein 0.0005 0.0009 0.0063
Schistosoma mansoni cytochrome P450 0.0004 0.0005 0.0015
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0118 0.2657
Echinococcus multilocularis aromatic amino acid decarboxylase 0.0012 0.004 0.0096
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0071 0.0594
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0071 0.0594
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0071 0.0594
Trichomonas vaginalis group II pyridoxal-5-phosphate decarboxylase, putative 0.0012 0.004 0.0331
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0307 1
Echinococcus granulosus protein Wnt 2 0.0014 0.0052 0.0158
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0031 0.2607
Loa Loa (eye worm) hypothetical protein 0.0003 0.0003 0.0018
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.056 0.4046
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0021 0.0083 0.6925
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0025 0.0061
Trypanosoma brucei unspecified product 0.0029 0.0119 0.2685
Brugia malayi RNase H family protein 0.0027 0.0109 0.0801
Trichomonas vaginalis conserved hypothetical protein 0.0003 0.0003 0.0021
Onchocerca volvulus 0.0003 0.0003 0.0003
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0021 0.0083 0.2796
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0033 0.01
Mycobacterium ulcerans glutamate decarboxylase 0.0012 0.004 0.004
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0004 0.0004 0.0004
Plasmodium vivax endonuclease, putative 0.0003 0.0001 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0003 0.0003 0.0021
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0003 0.0003 0.0008
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0021 0.0083 0.2698
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0004 0.0004 0.0004
Echinococcus granulosus geminin 0.0168 0.0756 0.2292
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0004 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0004 0.0004 0.0029
Echinococcus multilocularis wnt family member wnt11 2 0.0014 0.0052 0.0127
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0004 0.0005 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0307 0.6926
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0071 0.0172
Leishmania major hypothetical protein, conserved 0.0012 0.004 0.1289
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0071 0.5935
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0003 0.0003 0.0209
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0004 0.0005 0.0005
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0083 0.5867
Onchocerca volvulus 0.0018 0.0071 0.0506
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0004 0.0005 0.0005
Plasmodium vivax vivapain-3 0.0009 0.003 0.2134
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0046 0.0388
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0071 0.0594
Trichomonas vaginalis hypothetical protein 0.0003 0.0003 0.0024
Echinococcus granulosus flap endonuclease GEN 1 0.0006 0.0014 0.0042
Entamoeba histolytica cysteine protease, putative 0.0003 0.0003 0.0209
Echinococcus granulosus smad 0.0009 0.0026 0.0079
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0031 0.023
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0004 0.0004 0.0004
Plasmodium vivax unspecified product 0.0003 0.0003 0.0176
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0044 0.0997
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0017 0.0138
Schistosoma mansoni phenylalanine decarboxylase 0.0012 0.004 0.012
Onchocerca volvulus 0.0018 0.0071 0.0506
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0083 0.0613
Schistosoma mansoni exonuclease 0.0006 0.0014 0.0042
Trypanosoma brucei sphingosine 1-phosphate lyase, putative 0.0012 0.004 0.0893
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0004 0.0004 0.0336
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0203 0.1482
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0142 0.0345
Trypanosoma cruzi sphingosine 1-phosphate lyase, putative 0.0012 0.004 0.1289
Echinococcus multilocularis translational activator gcn1 0.0005 0.0012 0.0028
Brugia malayi cathepsin F-like cysteine proteinase 0.0003 0.0003 0.0018
Brugia malayi Cathepsin L-like precursor 0.0018 0.0071 0.0523
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0004 0.0004 0.0091
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0004 0.0005 0.0005
Brugia malayi cathepsin L precursor 0.0003 0.0003 0.0018
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0094 0.0228
Trypanosoma cruzi Pyridoxal-dependent decarboxylase conserved domain containing protein, putative 0.0012 0.004 0.1289
Schistosoma mansoni aldehyde dehydrogenase 0.0004 0.0004 0.0012
Schistosoma mansoni hypothetical protein 0.0016 0.0059 0.0178
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0118 0.2657
Echinococcus multilocularis protein Wnt 2 0.0014 0.0052 0.0127
Schistosoma mansoni aldehyde dehydrogenase 0.0004 0.0004 0.0012
Echinococcus granulosus poly adp ribose polymerase 2 0.0021 0.0083 0.0251
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0021 0.0083 0.0251
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0043 0.0131
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0004 0.0005 0.0005
Brugia malayi Aldehyde dehydrogenase protein 4 0.0004 0.0004 0.003
Entamoeba histolytica cysteine protease, putative 0.0009 0.003 0.2531
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0101 0.8469
Plasmodium falciparum serine repeat antigen 1 0.0003 0.0003 0.0209
Onchocerca volvulus 0.0029 0.0117 0.0847
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.0013 0.0046 0.0388
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0083 0.0693
Loa Loa (eye worm) hypothetical protein 0.0003 0.0003 0.0018
Echinococcus multilocularis cysteine protease 0.0018 0.0071 0.0172
Schistosoma mansoni SET domain protein 0.0003 0.0003 0.0009
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0006 0.0014 0.0042
Loa Loa (eye worm) kap beta 3 protein 0.0005 0.0012 0.0085
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0142 0.043
Loa Loa (eye worm) XPG I-region family protein 0.0006 0.0014 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0003 0.0003 0.0021
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0134 0.0405
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0004 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0083 0.0693
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0118 0.3975
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0004 0.0004 0.0004
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.005 0.0359
Brugia malayi cathepsin B-like cysteine proteinase 0.0003 0.0003 0.0018
Schistosoma mansoni hypothetical protein 0.0288 0.1303 0.3949
Trypanosoma cruzi ribonuclease H1, putative 0.0027 0.0109 0.354
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0313
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0233 0.0567
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0003 0.0003 0.0209
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0004 0.0004 0.0004
Trypanosoma cruzi major cysteine proteinase, putative 0.0003 0.0003 0.0081
Echinococcus multilocularis SAM domain containing protein 0.0013 0.0046 0.0113
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0006 0.0014 0.0454
Echinococcus granulosus exonuclease 1 0.0006 0.0014 0.0042
Schistosoma mansoni tankyrase 0.0147 0.0659 0.1999
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.084 0.2039
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0071 0.0215
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0071 0.0506
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0025 0.0076
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0313
Plasmodium falciparum zinc finger protein, putative 0.0003 0.0002 0.0198
Loa Loa (eye worm) hypothetical protein 0.0034 0.0142 0.1026
Trypanosoma cruzi cysteine protease, putative 0.0009 0.003 0.0986
Leishmania major aldehyde dehydrogenase, putative 0.0004 0.0004 0.0131
Echinococcus multilocularis cathepsin L 0.0009 0.003 0.0074
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0004 0.0005 0.0005
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0071 0.5935
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0003 0.0003 0.0209
Plasmodium falciparum serine repeat antigen 4 0.0003 0.0003 0.0209
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0004 0.0005 0.0005
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0021 0.0083 0.2698
Echinococcus granulosus importin subunit beta 1 0.0029 0.0118 0.0357
Brugia malayi mothers against decapentaplegic homolog 3 0.0004 0.0004 0.0033
Echinococcus multilocularis cathepsin b 0.0003 0.0003 0.0006
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0296 0.072
Schistosoma mansoni wnt related 0.0014 0.0052 0.0158
Plasmodium vivax DNA repair protein RAD2, putative 0.0006 0.0014 0.0984
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0004 0.0004 0.0336
Entamoeba histolytica cysteine protease, putative 0.0003 0.0003 0.0209
Brugia malayi MH2 domain containing protein 0.0125 0.056 0.4122
Loa Loa (eye worm) cysteine protease 0.0018 0.0071 0.0513
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0004 0.0004 0.0131
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0093 0.0778
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0307 0.6926
Entamoeba histolytica cysteine proteinase 2 0.0009 0.003 0.2531
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0004 0.0004 0.0011
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.003 0.2531
Loa Loa (eye worm) cathepsin B 0.0003 0.0003 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0046 0.0388
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0307 0.6926
Trypanosoma brucei ISWI complex protein 0.0003 0.0001 0.0015
Brugia malayi hypothetical protein 0.0013 0.0046 0.0342
Schistosoma mansoni cpg binding protein 0.0029 0.0117 0.0356
Onchocerca volvulus 0.0034 0.0142 0.1029
Schistosoma mansoni hypothetical protein 0.0013 0.0046 0.0141
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0004 0.0005 0.0005
Plasmodium falciparum serine repeat antigen 5 0.0003 0.0003 0.0209
Schistosoma mansoni DNA helicase recq5 0.001 0.0031 0.0095
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0043 0.3614
Schistosoma mansoni hypothetical protein 0.0013 0.0046 0.0141
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0071 0.0513
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0013 0.0046 0.1566
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0142 0.4789
Trypanosoma brucei ingi protein (ORF1) 0.0029 0.0119 0.2685
Leishmania major hypothetical protein, conserved 0.0025 0.0101 0.3299
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0004 0.0004 0.0004
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0004 0.0004 0.0336
Echinococcus multilocularis wingless type MMTV integration site family 0.0014 0.0052 0.0127
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.012 0.1
Entamoeba histolytica cysteine protease, putative 0.0009 0.003 0.2531
Plasmodium falciparum tyrosine kinase-like protein 0.0013 0.0046 0.3877
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0296 0.0899
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0004 0.0005 0.0005
Mycobacterium tuberculosis Probable glutamate decarboxylase GadB 0.0012 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0335
Toxoplasma gondii cytochrome p450 superfamily protein 0.0004 0.0005 0.017
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0004 0.0004 0.0131
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0003 0.0003 0.0021
Schistosoma mansoni smad 0.0004 0.0004 0.0013
Entamoeba histolytica hypothetical protein 0.0021 0.0083 0.6925
Brugia malayi RNA, U transporter 1 0.0081 0.0359 0.2643
Brugia malayi Smad1 0.0009 0.0026 0.0192
Brugia malayi Cathepsin L-like precursor 0.0006 0.0015 0.0109
Brugia malayi aldehyde dehydrogenase 0.0004 0.0004 0.003
Echinococcus granulosus poly ADP ribose polymerase 1 0.0021 0.0083 0.0251
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0004 0.0004 0.0004
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0306 0.1384 1
Loa Loa (eye worm) fibroinase 0.0018 0.0071 0.0513
Echinococcus granulosus pyridoxal dependent decarboxylase 0.0012 0.004 0.012
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0003 0.0003 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0083 0.0693
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0307 0.6926
Brugia malayi Pre-SET motif family protein 0.0034 0.0142 0.1045
Entamoeba histolytica cysteine protease, putative 0.0009 0.003 0.2531
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0071 0.0172
Echinococcus multilocularis flap endonuclease GEN 1 0.0006 0.0014 0.0034
Brugia malayi cathepsin L-like cysteine proteinase 0.0003 0.0003 0.0018
Plasmodium vivax unspecified product 0.0006 0.0015 0.1041
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.003 0.0092
Mycobacterium ulcerans aldehyde dehydrogenase 0.0004 0.0004 0.0004
Brugia malayi Papain family cysteine protease containing protein 0.0003 0.0003 0.0018
Giardia lamblia Alcohol dehydrogenase 0.0004 0.0004 0.0129
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0006 0.0014 0.0471
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0026 0.0079
Echinococcus granulosus cathepsin b 0.0003 0.0003 0.0008
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0296 0.0296
Loa Loa (eye worm) RecQ helicase 0.0023 0.0094 0.068
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0006 0.0014 0.0471
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0005 0.001 0.031
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0004 0.0004 0.001
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0003 0.0003 0.0008
Brugia malayi Cathepsin L-like precursor 0.0012 0.0043 0.0318
Brugia malayi wnt family protein 0.0014 0.0052 0.0384
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0004 0.0005 0.0164
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0004 0.0004 0.0131
Echinococcus granulosus cytochrome P450 2K1 0.0004 0.0005 0.0015
Echinococcus granulosus Protein Wnt-111 0.0014 0.0052 0.0158
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0013 0.0046 0.0342
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0004 0.0004 0.0012
Loa Loa (eye worm) cytochrome P450 0.0004 0.0005 0.0036
Entamoeba histolytica cysteine protease, putative 0.0009 0.003 0.2531
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0071 0.0594
Trichomonas vaginalis flap endonuclease-1, putative 0.0006 0.0014 0.0117
Echinococcus granulosus sphingosine 1 phosphate lyase 1 0.0012 0.004 0.012
Mycobacterium tuberculosis Probable histidinol dehydrogenase HisD (HDH) 0.2193 1 1
Entamoeba histolytica exonuclease, putative 0.0006 0.0014 0.1166
Trypanosoma cruzi cysteine proteinase, putative 0.0009 0.003 0.0986
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0203 0.0617
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0335
Echinococcus multilocularis exonuclease 1 0.0006 0.0014 0.0034
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0203 0.0617
Entamoeba histolytica cysteine protease, putative 0.0018 0.0071 0.5935
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0083 0.0252
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0071 0.0172
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0004 0.0004 0.0004
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0071 0.2312
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0083 0.0693
Echinococcus multilocularis WNT 0.0014 0.0052 0.0127
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0031 0.023
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0004 0.0005 0.0005
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.005 0.1617
Toxoplasma gondii HEAT repeat-containing protein 0.0005 0.0012 0.0396
Schistosoma mansoni flap endonuclease-1 0.0026 0.0107 0.0324
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0006 0.0014 0.0034
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0003 0.0003 0.0008
Trypanosoma cruzi ISWI complex protein 0.0003 0.0001 0.0022
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0004 0.0004 0.0091
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0004 0.0005 0.0113
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.012 0.8432
Brugia malayi WGR domain containing protein 0.0021 0.0083 0.061
Schistosoma mansoni blooms syndrome DNA helicase 0.0005 0.001 0.0029
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0033 0.008
Schistosoma mansoni hypothetical protein 0.0016 0.0059 0.0178
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0083 0.1878
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0006 0.0015 0.0107
Echinococcus granulosus cathepsin L 0.0003 0.0003 0.0008
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0142 0.1043
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0004 0.0005 0.0005
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0071 0.0506
Leishmania major cathepsin L-like protease 0.0018 0.0071 0.2312
Loa Loa (eye worm) MH2 domain-containing protein 0.0004 0.0004 0.0032
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0013 0.0046 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0046 0.0388
Schistosoma mansoni cathepsin s 0.0006 0.0015 0.0045
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0003 0.0003 0.0176
Echinococcus granulosus transportin 1 0.0005 0.0012 0.0036
Schistosoma mansoni cathepsin C 0.0003 0.0003 0.0008
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0296 0.9648
Schistosoma mansoni phosphoglucomutase 0.0027 0.0109 0.033
Echinococcus multilocularis Smad4 0.0009 0.0026 0.0063
Echinococcus granulosus cysteine protease 0.0009 0.003 0.0092
Brugia malayi Importin beta-1 subunit 0.0029 0.0118 0.0867
Trichomonas vaginalis flap endonuclease-1, putative 0.0006 0.0014 0.0117
Entamoeba histolytica DNA-repair protein, putative 0.0006 0.0014 0.1166
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0003 0.0003 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0003 0.0003 0.0021
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0011 0.0034
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0003 0.0003 0.0024
Brugia malayi Cytochrome P450 family protein 0.0014 0.005 0.0366
Trichomonas vaginalis flap endonuclease-1, putative 0.0006 0.0014 0.0117
Brugia malayi cathepsin Z-like cysteine proteinase 0.0003 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0286
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0004 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0107
Schistosoma mansoni hypothetical protein 0.0168 0.0756 0.2292
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0071 0.0594
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.012 0.4038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0071 0.0594
Mycobacterium leprae Conserved hypothetical protein 0.0004 0.0005 0.0005
Leishmania major cathepsin L-like protease 0.0018 0.0071 0.2312
Echinococcus multilocularis cpg binding protein 0.003 0.0125 0.0303
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0017 0.0138
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0003 0.0003 0.0018
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0296 0.0899
Echinococcus multilocularis 0.0004 0.0005 0.0012
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0004 0.0004 0.001
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0021 0.0083 0.0251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0003 0.0003 0.0021
Brugia malayi hypothetical protein 0.0016 0.0061 0.0448
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0004 0.0004 0.0012
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0006 0.0014 0.0042
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0239 0.7769
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0004 0.0005 0.0005
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0031 0.0076
Loa Loa (eye worm) hypothetical protein 0.005 0.0213 0.1541
Brugia malayi Cathepsin L-like precursor 0.0012 0.0043 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0083 0.0693
Brugia malayi Liprin-alpha 2 0.0013 0.0046 0.0342
Onchocerca volvulus 0.0018 0.0071 0.0506
Schistosoma mansoni sarm1 0.0013 0.0046 0.0141
Echinococcus granulosus importin 5 0.0005 0.0012 0.0036
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0101
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.005 0.0359
Echinococcus granulosus microtubule associated protein 2 0.0725 0.3299 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0059 0.0142
Schistosoma mansoni importin beta-1 0.0029 0.0118 0.0357
Brugia malayi Cathepsin L-like precursor 0.0018 0.0071 0.0523
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0026 0.0188
Leishmania major hypothetical protein, conserved 0.0005 0.0012 0.0382
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0119 0.2685
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0004 0.0005 0.0005
Schistosoma mansoni aldehyde dehydrogenase 0.0004 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.0069
Trypanosoma brucei RNA helicase, putative 0.01 0.0444 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0046 0.0388
Plasmodium falciparum protein kinase, putative 0.0013 0.0046 0.3877
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0004 0.0004 0.0136
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0071 0.5935
Trypanosoma brucei Pyridoxal-dependent decarboxylase conserved domain containing protein, putative 0.0012 0.004 0.0893
Echinococcus granulosus liprin beta 1 0.0013 0.0046 0.0141
Loa Loa (eye worm) glutamate decarboxylase GAD1 0.0012 0.004 0.0286
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0233 0.0708
Leishmania major aldehyde dehydrogenase, putative 0.0004 0.0004 0.0131
Brugia malayi Cytochrome P450 family protein 0.0014 0.005 0.0366
Plasmodium falciparum serine repeat antigen 3 0.0003 0.0003 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0071 0.0594
Brugia malayi kap beta 3 protein 0.0005 0.0012 0.0086
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0083 0.2711
Plasmodium vivax vivapain-1 0.0009 0.003 0.2134
Brugia malayi hypothetical protein 0.0013 0.0046 0.0342
Entamoeba histolytica hypothetical protein 0.0003 0.0003 0.0209
Schistosoma mansoni myst-related protein 0.0003 0.0002 0.0007
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0004 0.0004 0.0012
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0071 0.0523
Leishmania major hypothetical protein, conserved 0.0006 0.0014 0.0454
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0003 0.0003 0.0021
Echinococcus multilocularis liprin alpha 2 0.0013 0.0046 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0083 0.0693
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0059 0.0142
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.005 0.1617
Loa Loa (eye worm) MBCTL1 0.0054 0.0233 0.1687
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0031 0.1053
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0071 0.0172
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0003 0.0003 0.0018
Echinococcus multilocularis geminin 0.0168 0.0756 0.1835
Loa Loa (eye worm) nuclear factor I 0.0005 0.0009 0.0062
Brugia malayi MH2 domain containing protein 0.0004 0.0004 0.0033
Brugia malayi Cathepsin L-like precursor 0.0018 0.0071 0.0523
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0004 0.0004 0.0004
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0003 0.0003 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0009 0.003 0.0683
Trypanosoma cruzi ribonuclease H1, putative 0.0027 0.0109 0.354
Entamoeba histolytica hypothetical protein 0.0023 0.0093 0.7777
Entamoeba histolytica cysteine protease, putative 0.0003 0.0003 0.0209
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0213 0.1541
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0004 0.0004 0.0131
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.003 0.0223
Brugia malayi hypothetical protein 0.0025 0.0101 0.0746
Schistosoma mansoni ran 0.0021 0.0083 0.0252
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0004 0.0004 0.0012
Echinococcus granulosus cpg binding protein 0.003 0.0125 0.0378
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0005 0.001 0.0321
Schistosoma mansoni smad1 5 8 and 0.0009 0.0026 0.0079
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0004 0.0005 0.0164
Brugia malayi Muscleblind-like protein 0.0148 0.0665 0.4894
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0017 0.0138
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.0004 0.0004 0.0004
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0093 0.0778
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0101 0.3299
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0003 0.0003 0.0209
Schistosoma mansoni hypothetical protein 0.0013 0.0046 0.0141
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0004 0.0004 0.0091
Leishmania major cathepsin L-like protease 0.0018 0.0071 0.2312
Schistosoma mansoni phenylalanine decarboxylase 0.0012 0.004 0.012
Plasmodium vivax tyrosine kinase-like protein, putative 0.0013 0.0046 0.3269
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.0004 0.0004 0.0004
Leishmania major cathepsin L-like protease 0.007 0.0307 1
Plasmodium vivax vivapain-2 0.0018 0.0071 0.5005
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0296 0.0899
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0071 0.0594
Entamoeba histolytica cysteine protease, putative 0.0009 0.003 0.2531
Brugia malayi Cytochrome P450 family protein 0.0004 0.0005 0.0037
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0071 0.0215
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0003 0.0003 0.0176
Brugia malayi wnt family protein 0.0014 0.0052 0.0384
Entamoeba histolytica hypothetical protein 0.0021 0.0083 0.6925
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0083 0.0693
Brugia malayi mbt repeat family protein 0.0047 0.0203 0.1498
Schistosoma mansoni cathepsin S (C01 family) 0.0003 0.0003 0.0008
Brugia malayi cathepsin L-like precursor 0.0012 0.0043 0.0318
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0043 0.0361
Echinococcus granulosus translational activator gcn1 0.0005 0.0012 0.0036
Trypanosoma brucei cysteine peptidase C (CPC) 0.0003 0.0003 0.0056
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0335
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0004 0.0004 0.0004
Leishmania major aldehyde dehydrogenase, putative 0.0004 0.0004 0.0131
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0083 0.281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0003 0.0003 0.0021
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.0004 0.0004 0.0004
Echinococcus granulosus tankyrase 0.0147 0.0658 0.1996
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0107
Brugia malayi Pyridoxal-dependent decarboxylase conserved domain containing protein 0.0012 0.004 0.0292
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0071 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0017 0.0138
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0313
Plasmodium falciparum serine repeat antigen 8 0.0003 0.0003 0.0209

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.59 uM Inhibitory activity against HIV-1 wild-type reverse transcriptase. ChEMBL. 9685236
IC50 (binding) = 0.59 uM Inhibitory activity against HIV-1 wild-type reverse transcriptase. ChEMBL. 9685236
Inhibition (binding) = 17 % Inhibitory activity against HIV-1 Y188L reverse transcriptase at 1 microM concentration ChEMBL. 9685236
Inhibition (binding) = 17 % Inhibitory activity against HIV-1 Y188L reverse transcriptase at 1 microM concentration ChEMBL. 9685236
Inhibition (binding) = 18 % Inhibitory activity against HIV-1 Y181C reverse transcriptase at 1 microM concentration ChEMBL. 9685236
Inhibition (binding) = 18 % Inhibitory activity against HIV-1 Y181C reverse transcriptase at 1 microM concentration ChEMBL. 9685236

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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