Detailed information for compound 1078795

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 304.751 | Formula: C14H9ClN2O2S
  • H donors: 0 H acceptors: 2 LogP: 4.54 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)S/C=C/c1ccc2c(c1)[n+]([O-])on2
  • InChi: 1S/C14H9ClN2O2S/c15-11-2-4-12(5-3-11)20-8-7-10-1-6-13-14(9-10)17(18)19-16-13/h1-9H/b8-7+
  • InChiKey: VAEAEUCYAQOGJN-BQYQJAHWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus geminin 0.0349 0.0451 0.2369
Brugia malayi AMP-binding enzyme family protein 0.0218 0.0275 0.1438
Brugia malayi Death domain containing protein 0.0031 0.0024 0.0116
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0024 0.0116
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0049
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0073 0.0081 0.2818
Brugia malayi Patched protein homolog 1 0.0055 0.0056 0.0286
Echinococcus multilocularis survival motor neuron protein 1 0.143 0.1904 0.1904
Brugia malayi Patched family protein 0.0055 0.0056 0.0286
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0218 0.0275 0.4472
Onchocerca volvulus 0.0084 0.0096 0.1362
Loa Loa (eye worm) hypothetical protein 0.0167 0.0207 0.1088
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0009 0.0049
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.0071 0.1095
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0081 0.1259
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0061 0.0064 0.0422
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0017 0.0006 0.0039
Giardia lamblia Kinase, PLK 0.0096 0.0111 0.5168
Schistosoma mansoni hypothetical protein 0.013 0.0158 0.0819
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0045 0.0235
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0045 0.0045
Giardia lamblia Macrophage migration inhibitory factor 0.0145064 0.5 0.5
Trypanosoma brucei phosphoglycerate kinase 0.0169 0.021 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0064 0.0069 0.1057
Loa Loa (eye worm) hypothetical protein 0.0061 0.0064 0.0338
Onchocerca volvulus 0.0292 0.0374 0.5758
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0005 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0213 0.3259
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0009 0.0049
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0065 0.0342
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0039 0.0205
Schistosoma mansoni hypothetical protein 0.0374 0.0486 0.2567
Trypanosoma brucei pyruvate kinase 1, putative 0.0167 0.0207 0.9847
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0065 0.2227
Schistosoma mansoni inositol monophosphatase 0.0073 0.0081 0.0411
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0081 0.1259
Trypanosoma brucei unspecified product 0.0039 0.0035 0.151
Brugia malayi nuclear hormone receptor 0.0042 0.0039 0.0195
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0115 0.0137 0.0708
Brugia malayi AMP-binding enzyme family protein 0.0064 0.0069 0.0351
Echinococcus granulosus cpg binding protein 0.0034 0.0028 0.0148
Toxoplasma gondii ABC1 family protein 0.0073 0.0081 0.3728
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0049
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0154 0.0189 0.3053
Echinococcus granulosus GPCR family 2 0.008 0.009 0.0474
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0218 0.0275 1
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0225 0.3453
Echinococcus multilocularis protein dispatched 1 0.0443 0.0578 0.0578
Schistosoma mansoni cellular tumor antigen P53 0.02 0.0252 0.132
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0049
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0065
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0039 0.0187
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0047 0.0244
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0009 0.0038
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0209 0.3204
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0081 0.1259
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0049
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0035 0.0184
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0061 0.0064 0.2168
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0039 0.0195
Loa Loa (eye worm) hypothetical protein 0.0073 0.0081 0.0425
Brugia malayi TAR-binding protein 0.0134 0.0162 0.0843
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0064 0.0932
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0039 0.0187
Trypanosoma brucei pyruvate kinase 1 0.0167 0.0207 0.9847
Schistosoma mansoni hypothetical protein 0.0017 0.0006 0.0011
Plasmodium falciparum pyruvate kinase 0.0167 0.0207 0.9847
Trypanosoma brucei unspecified product 0.0027 0.0019 0.072
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0039 0.0187
Brugia malayi follicle stimulating hormone receptor 0.0246 0.0313 0.1635
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0049
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0081 0.3741
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0047 0.0652
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0066 0.0071 0.2466
Mycobacterium ulcerans beta-lactamase 0.0073 0.0081 0.2808
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0096 0.0096
Echinococcus multilocularis muscleblind protein 0.0145 0.0178 0.0178
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0115 0.0137 0.0708
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0919 0.1218 0.6467
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0009 0.0038
Brugia malayi hypothetical protein 0.0055 0.0056 0.0286
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0169 0.021 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0218 0.0275 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Onchocerca volvulus 0.0073 0.0081 0.1129
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0009 0.0009
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0017 0.0006 0.0022
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0035 0.0175
Onchocerca volvulus 0.0064 0.0069 0.0936
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0035 0.151
Brugia malayi Phosphoglycerate kinase 0.0169 0.021 0.1095
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0014 0.0507
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0039 0.0195
Trichomonas vaginalis antibiotic synthetase, putative 0.0064 0.0069 0.0998
Plasmodium falciparum thioredoxin reductase 0.0048 0.0047 0.2082
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0061 0.0064 0.0328
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0039 0.0205
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0039 0.0039
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0064 0.0069 0.3134
Loa Loa (eye worm) hypothetical protein 0.0073 0.0081 0.0425
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0073 0.0081 0.3741
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0035 0.0184
Echinococcus granulosus tumor protein p63 0.1368 0.182 0.956
Echinococcus granulosus pyruvate kinase 0.0086 0.0098 0.0514
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0081 0.119
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0163 0.0201 0.7264
Schistosoma mansoni zinc finger protein 0.002 0.0009 0.0028
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0039 0.0205
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0063 0.0063
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0014 0.0507
Loa Loa (eye worm) hypothetical protein 0.0052 0.0053 0.0277
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0064 0.0069 0.3134
Brugia malayi Pre-SET motif family protein 0.0432 0.0563 0.2951
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0065 0.0326
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.0111 0.3944
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0129 0.2058
Plasmodium falciparum thioredoxin reductase 0.0017 0.0005 0.0046
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0014 0.0507
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0163 0.0201 0.325
Mycobacterium ulcerans acyl-CoA synthetase 0.0064 0.0069 0.2355
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0039 0.047
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0064 0.0069 0.2355
Mycobacterium ulcerans acyl-CoA synthetase 0.0064 0.0069 0.2355
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0035 0.151
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0014 0.0314
Echinococcus granulosus dna polymerase kappa 0.0039 0.0035 0.0184
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0246 0.0313 0.1643
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0012 0.0045
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0146 0.5182
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0049
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0061 0.0064 0.2199
Loa Loa (eye worm) hypothetical protein 0.0388 0.0505 0.265
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0047 0.0246
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0064 0.0069 0.1057
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0035 0.151
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0039 0.0195
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0005 0.0005
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0039 0.047
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0051 0.0051 0.0256
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0064 0.0069 0.1057
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0111 0.1662
Echinococcus multilocularis tar DNA binding protein 0.0134 0.0162 0.0162
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0009 0.0049
Toxoplasma gondii propionate-CoA ligase 0.0064 0.0069 0.3134
Schistosoma mansoni hypothetical protein 0.008 0.009 0.046
Brugia malayi hypothetical protein 0.143 0.1904 1
Plasmodium falciparum macrophage migration inhibitory factor 0.0145064 0.5 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0046 0.0647
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0061 0.0064 0.0932
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0017 0.0006 0.0022
Schistosoma mansoni lipoxygenase 0.002 0.0009 0.0029
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0205
Schistosoma mansoni hypothetical protein 0.008 0.009 0.046
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0064 0.2929
Loa Loa (eye worm) hypothetical protein 0.0905 0.1199 0.6296
Trypanosoma brucei trypanothione reductase 0.0048 0.0047 0.2082
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0049
Echinococcus granulosus nibrin 0.0061 0.0064 0.0338
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0019 0.072
Plasmodium vivax acetyl-CoA synthetase, putative 0.0064 0.0069 0.3134
Schistosoma mansoni hypothetical protein 0.008 0.009 0.046
Onchocerca volvulus Netrin receptor homolog 0.0031 0.0024 0.0232
Trypanosoma brucei polo-like protein kinase 0.0096 0.0111 0.519
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0014 0.0352
Echinococcus multilocularis pyruvate kinase 0.0167 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0476 0.0622 0.3267
Brugia malayi intermediate filament protein 0.0027 0.0019 0.0088
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0005 0.0003
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0009 0.0049
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0213 0.3259
Brugia malayi Patched family protein 0.0055 0.0056 0.0286
Brugia malayi Patched family protein 0.0055 0.0056 0.0286
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0005 0.0035
Onchocerca volvulus 0.002 0.0009 0.0003
Schistosoma mansoni microtubule-associated protein tau 0.1412 0.1881 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0065
Loa Loa (eye worm) hypothetical protein 0.0061 0.0064 0.0338
Schistosoma mansoni cpg binding protein 0.0034 0.0028 0.0129
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0049
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0005 0.0032
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0169 0.021 1
Schistosoma mansoni hypothetical protein 0.0292 0.0374 0.1975
Schistosoma mansoni pyruvate kinase 0.0086 0.0098 0.05
Brugia malayi hypothetical protein 0.002 0.0009 0.0039
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0005
Brugia malayi hypothetical protein 0.0022 0.0012 0.0055
Brugia malayi nuclear receptor NHR-67 0.002 0.0009 0.0038
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0066 0.3017
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0064 0.0069 0.2355
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0213 0.3259
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0064 0.0069 0.1057
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0467 0.061 1
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0004 0.0021
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0062 0.0066 0.3017
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0095
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0129 0.2058
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0169 0.021 0.3217
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0071 0.0071
Loa Loa (eye worm) acetyltransferase 0.0162 0.02 0.105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0005 0.0046
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0169 0.0209 0.11
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.013 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0117 0.0139 0.0731
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0005 0.0046
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0004 0.0004
Mycobacterium leprae Probable lipase LipE 0.0073 0.0081 0.278
Mycobacterium ulcerans acyl-CoA synthetase 0.0064 0.0069 0.2355
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0111 0.1662
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0162 0.0844
Echinococcus multilocularis pyruvate kinase 0.0086 0.0098 0.0098
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0064 0.0069 0.3134
Brugia malayi Calcitonin receptor-like protein seb-1 0.0253 0.0323 0.1687
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0162 0.0844
Brugia malayi conserved hypotetical protein 0.002 0.0009 0.0038
Mycobacterium ulcerans lipase LipD 0.0073 0.0081 0.2808
Echinococcus granulosus death domain containing protein 0.0031 0.0024 0.0126
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0039 0.0187
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0009 0.0266
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0039 0.0205
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0021
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0081 0.3728
Onchocerca volvulus Pyruvate kinase homolog 0.0167 0.0207 0.312
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0017 0.0006 0.0022
Brugia malayi Muscleblind-like protein 0.0145 0.0178 0.0926
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0019 0.0098
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0017 0.0006 0.0039
Brugia malayi Patched family protein 0.0055 0.0056 0.0286
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0039 0.0039
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0005 0.0014
Plasmodium vivax replication factor C subunit 1, putative 0.0061 0.0064 0.2929
Onchocerca volvulus 0.0073 0.0081 0.1129
Brugia malayi nuclear receptor RXR 0.0022 0.0012 0.0055
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0065 0.0065
Echinococcus multilocularis lamin dm0 0.0027 0.0019 0.0019
Loa Loa (eye worm) beta-lactamase 0.0073 0.0081 0.0425
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0005 0.0032
Giardia lamblia Pyruvate kinase 0.0167 0.0207 0.9846
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0045 0.0218
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0163 0.0201 0.957
Mycobacterium ulcerans acyl-CoA synthetase 0.0064 0.0069 0.2355
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0081 0.2808
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0061 0.0061
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0061 0.0064 0.0932
Loa Loa (eye worm) hypothetical protein 0.0073 0.0081 0.0425
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0017 0.0006 0.0022
Brugia malayi steroid hormone receptor 0.0042 0.0039 0.0195
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0035 0.0503
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0017 0.0006 0.0022
Brugia malayi ecdysone receptor 0.002 0.0009 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0039 0.0195
Brugia malayi jmjC domain containing protein 0.0016 0.0004 0.001
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0017 0.0006 0.0039
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0035 0.151
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0063 0.0329
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0017 0.0006 0.0097
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0096 0.0489
Plasmodium vivax acyl-CoA synthetase, putative 0.0163 0.0201 0.9572
Plasmodium falciparum replication factor C subunit 1, putative 0.0061 0.0064 0.2929
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0047 0.2064
Brugia malayi Cytochrome P450 family protein 0.0017 0.0006 0.0021
Schistosoma mansoni loxhd1 0.002 0.0009 0.0029
Onchocerca volvulus 0.0063 0.0067 0.0906
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0035 0.0174
Schistosoma mansoni methyl-cpg binding protein mbd 0.0052 0.0053 0.026
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0017 0.0006 0.0039
Loa Loa (eye worm) TAR-binding protein 0.0134 0.0162 0.0853
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0218 0.0275 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0026 0.0135
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0071 0.244
Loa Loa (eye worm) glutathione reductase 0.0048 0.0047 0.0246
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0111 0.0571
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0035 0.151
Plasmodium falciparum glutathione reductase 0.0017 0.0005 0.0046
Leishmania major 4-coumarate:coa ligase-like protein 0.0218 0.0275 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0115 0.0137 0.0719
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0014 0.0463
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0039 0.0195
Leishmania major macrophage migration inhibitory factor-like protein 0.0145064 0.5 0.5
Schistosoma mansoni hypothetical protein 0.0368 0.0478 0.2524
Loa Loa (eye worm) hypothetical protein 0.02 0.0252 0.1321
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0017 0.0092
Loa Loa (eye worm) hypothetical protein 0.0084 0.0096 0.0502
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0009 0.0038
Schistosoma mansoni hypothetical protein 0.002 0.0009 0.0029
Schistosoma mansoni thyroid hormone receptor 0.0172 0.0214 0.112
Plasmodium falciparum glutathione reductase 0.0048 0.0047 0.2082
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0066 0.0071 0.0357
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0039 0.0187
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0019 0.0098
Leishmania major macrophage migration inhibitory factor-like protein 0.0169 0.0209 0.7568
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0162 0.02 0.02
Brugia malayi Thioredoxin reductase 0.0048 0.0047 0.0236
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0065 0.1
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0049
Loa Loa (eye worm) patched family protein 0.0055 0.0056 0.0296
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0064 0.0069 0.1057
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0205
Schistosoma mansoni nuclear receptor 0.002 0.0009 0.0028
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0081 0.0425
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0039 0.0195
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0009 0.0009
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0064 0.0069 0.1057
Loa Loa (eye worm) patched family protein 0.0055 0.0056 0.0296
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0301 0.0387 0.0387
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0039 0.0039
Onchocerca volvulus 0.0061 0.0064 0.0869
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0064 0.0069 0.2355
Brugia malayi hypothetical protein 0.0061 0.0064 0.0328
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0017 0.0006 0.0022
Trypanosoma brucei DNA polymerase eta, putative 0.0065 0.007 0.3188
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0098
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0073 0.0081 0.0425
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0056 0.0295
Brugia malayi beta-lactamase 0.0073 0.0081 0.0415
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0049
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0017 0.0657
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0061 0.0064 0.0932
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0064 0.0069 0.1057
Schistosoma mansoni hypothetical protein 0.0374 0.0486 0.2567
Echinococcus multilocularis pyruvate kinase 0.0086 0.0098 0.0098
Brugia malayi Bm-MIF-1, identical 0.0145064 0.5 0.5
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0005 0.0046
Mycobacterium ulcerans hypothetical protein 0.0218 0.0275 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0064 0.0069 0.1057
Brugia malayi nuclear receptor NHR-88 0.0042 0.0039 0.0195
Brugia malayi Inositol-1 0.0073 0.0081 0.0416
Brugia malayi jmjC domain containing protein 0.0016 0.0004 0.001
Echinococcus granulosus pyruvate kinase 0.0167 0.0207 0.1088
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0081 0.3741
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0064 0.0069 0.1057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0005 0.0032
Schistosoma mansoni cpg binding protein 0.0034 0.0028 0.0129
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0261 0.0334 0.1744
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0005 0.0026
Toxoplasma gondii pyruvate kinase PyKII 0.0086 0.0098 0.4551
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0111 0.1662
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Chlamydia trachomatis phosphoglycerate kinase 0.0169 0.021 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0066 0.0071 0.2406
Leishmania major 4-coumarate:coa ligase-like protein 0.0218 0.0275 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0039 0.0187
Brugia malayi hypothetical protein 0.002 0.0009 0.0038
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0017 0.0006 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.0334 0.515
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0064 0.0069 0.036
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.0111 0.0111
Onchocerca volvulus 0.0218 0.0275 0.4197
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0014 0.0507
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0017 0.0092
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0004 0.0021
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0064 0.0069 0.0351
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0005 0.0035
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0145064 0.5 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0064 0.0069 0.2355
Brugia malayi latrophilin 2 splice variant baaae 0.0173 0.0215 0.1121
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0071 0.244
Brugia malayi CXXC zinc finger family protein 0.0032 0.0026 0.0125
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0005 0.0046
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0035 0.151
Echinococcus multilocularis nibrin 0.0061 0.0064 0.0064
Echinococcus granulosus lamin dm0 0.0027 0.0019 0.0098
Loa Loa (eye worm) patched family protein 0.0055 0.0056 0.0296
Plasmodium falciparum pyruvate kinase 2 0.0086 0.0098 0.4551
Trichomonas vaginalis esterase, putative 0.0073 0.0081 0.119
Brugia malayi ImpB/MucB/SamB family protein 0.0065 0.007 0.0356
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0064 0.0069 0.2325
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0127
Brugia malayi Myosin head containing protein 0.0055 0.0056 0.0286
Echinococcus granulosus expressed conserved protein 0.085 0.1125 0.5909
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Echinococcus multilocularis tumor protein p63 0.1368 0.182 0.182
Mycobacterium tuberculosis Conserved protein 0.0073 0.0081 0.1259
Echinococcus granulosus pyruvate kinase 0.0086 0.0098 0.0514
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0017 0.0466
Chlamydia trachomatis pyruvate kinase 0.0167 0.0207 0.9846
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0081 0.119
Trypanosoma brucei phosphoglycerate kinase 0.0169 0.021 1
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0005 0.0046
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0064 0.0069 0.2325
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0047 0.0652
Loa Loa (eye worm) pyruvate kinase 0.0167 0.0207 0.1088
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0005 0.0046
Onchocerca volvulus 0.0064 0.0069 0.0936
Schistosoma mansoni rab6-interacting 0.002 0.0009 0.0029
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0081 0.119
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0019 0.072
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0017 0.0006 0.0039
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0061 0.0064 0.2896
Brugia malayi Pyruvate kinase, M2 isozyme 0.0167 0.0207 0.1079
Onchocerca volvulus 0.0076 0.0084 0.1181
Echinococcus granulosus pyruvate kinase 0.0167 0.0207 0.1088
Echinococcus granulosus Niemann Pick C1 protein 0.0905 0.1199 0.6296
Schistosoma mansoni DNA ligase IV 0.0061 0.0064 0.0322
Loa Loa (eye worm) doublecortin family protein 0.002 0.0009 0.0049
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0039 0.0187
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0081 0.1259
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0064 0.2929
Onchocerca volvulus 0.0055 0.0056 0.0743
Echinococcus granulosus dnaJ subfamily B 0.0457 0.0596 0.3131
Schistosoma mansoni hypothetical protein 0.0349 0.0451 0.2382
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0005 0.0046
Entamoeba histolytica phosphoglycerate kinase, putative 0.0169 0.021 0.1654
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0039 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0039 0.0195
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0169 0.021 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0064 0.0069 0.2355
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0145064 0.5 0.5
Echinococcus multilocularis geminin 0.0349 0.0451 0.0451
Brugia malayi hypothetical protein 0.0055 0.0056 0.0286
Schistosoma mansoni lipoxygenase 0.0056 0.0058 0.0286
Loa Loa (eye worm) hypothetical protein 0.0163 0.0201 0.1058
Trichomonas vaginalis set domain proteins, putative 0.0492 0.0643 1
Giardia lamblia Phosphoglycerate kinase 0.0169 0.021 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0005 0.0046
Brugia malayi AMP-binding enzyme family protein 0.0218 0.0275 0.1438
Echinococcus granulosus phosphoglycerate kinase 1 0.0169 0.021 0.1104
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0041 0.1806
Loa Loa (eye worm) STAT protein 0.0136 0.0166 0.0869
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0009 0.0028
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0162 0.02 0.1045
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0063 0.0329
Schistosoma mansoni phosphoglycerate kinase 0.0169 0.021 0.11
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0035 0.151
Leishmania major pyruvate kinase 0.0167 0.0207 0.7482
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0063 0.0063
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0012 0.0045
Loa Loa (eye worm) hypothetical protein 0.0163 0.0201 0.1058
Brugia malayi AMP-binding enzyme family protein 0.0218 0.0275 0.1438
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0035 0.151
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0064 0.0069 0.3134
Schistosoma mansoni cytochrome P450 0.0017 0.0006 0.0011
Entamoeba histolytica pyruvate kinase, putative 0.0117 0.0139 0.1054
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0017 0.0006 0.0039
Entamoeba histolytica hypothetical protein 0.0368 0.0478 0.3911
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0034 0.1434
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0009 0.0049
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0017 0.0006 0.0022
Echinococcus granulosus nuclear factor of activated T cells 5 0.0301 0.0387 0.2033
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0146 0.2328
Brugia malayi nuclear receptor NHR-88 0.002 0.0009 0.0038
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0081 0.1259
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0081 0.119
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0031 0.0024 0.0108
Loa Loa (eye worm) hypothetical protein 0.143 0.1904 1
Toxoplasma gondii patched family protein 0.0055 0.0056 0.2541
Brugia malayi Pre-SET motif family protein 0.0063 0.0067 0.0341
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0388 0.0505 0.265
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0017 0.0006 0.0022
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0004 0.0021
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0065 0.0341
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0064 0.0069 0.0458
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0061 0.0318
Echinococcus granulosus Ankyrin 0.0031 0.0024 0.0127
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0017 0.0092
Brugia malayi jmjC domain containing protein 0.0016 0.0004 0.001
Brugia malayi Patched related family protein 12 0.0055 0.0056 0.0286
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0081 0.0415
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0213 0.3259
Leishmania major cytochrome p450-like protein 0.0017 0.0006 0.0074
Brugia malayi isocitrate dehydrogenase 0.0016 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0061 0.0064 0.0338
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0049
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0457 0.0596 0.3155
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0039 0.0205
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0064 0.0069 0.3134
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0005 0.0032
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0017 0.0006 0.0039
Loa Loa (eye worm) hypothetical protein 0.0145 0.0178 0.0935
Leishmania major 4-coumarate:coa ligase-like protein 0.0218 0.0275 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0081 0.041
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0039 0.0205
Leishmania major cytochrome p450-like protein 0.0026 0.0017 0.0499
Echinococcus granulosus Protein patched homolog 1 0.0388 0.0505 0.265
Trichomonas vaginalis conserved hypothetical protein 0.0145064 0.5 0.5
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0005 0.0005
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0039 0.0195
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0065 0.2227
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0035 0.1147
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.0111 0.1605
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0017 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0218 0.0275 0.1447
Trichomonas vaginalis replication factor C large subunit, putative 0.0061 0.0064 0.0932
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0009 0.0009
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0005 0.0046
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0064 0.0069 0.2355
Brugia malayi Patched related family protein 4 0.0055 0.0056 0.0286
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0006 0.0097
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0005 0.0032
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0017 0.0006 0.0022
Leishmania major macrophage migration inhibitory factor-like protein 0.0145064 0.5 0.5
Brugia malayi acetyltransferase, GNAT family protein 0.0162 0.02 0.1041
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0129 0.4575
Loa Loa (eye worm) hypothetical protein 0.0115 0.0137 0.0719
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.0071 0.1093
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0005 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0039 0.0195
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0162 0.0844
Brugia malayi Uncoordinated protein 44 0.0031 0.0024 0.0116
Loa Loa (eye worm) hypothetical protein 0.0065 0.007 0.0366
Loa Loa (eye worm) hypothetical protein 0.0061 0.0064 0.0338
Brugia malayi Nuclear hormone receptor E75 0.002 0.0009 0.0038
Echinococcus granulosus sterol regulatory element binding protein 0.0388 0.0505 0.265
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0205
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0111 0.519
Echinococcus granulosus histone acetyltransferase KAT2B 0.0157 0.0194 0.1018
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0064 0.0069 0.2355
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Trypanosoma cruzi pyruvate kinase 2, putative 0.0167 0.0207 0.9847
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0067 0.0334
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0169 0.0209 0.1647
Brugia malayi topoisomerase 0.0061 0.0064 0.0328
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0072 0.0079 0.0417
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0017 0.0657
Brugia malayi pyruvate kinase, muscle isozyme 0.0035 0.003 0.0147
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0035 0.0166
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0072 0.0079 0.0417
Onchocerca volvulus 0.0027 0.0019 0.0149
Echinococcus granulosus pyruvate kinase 0.0086 0.0098 0.0514
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0061 0.0064 0.2929
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0261 0.0334 0.1753
Schistosoma mansoni methyl-cpg binding protein mbd 0.0052 0.0053 0.026
Loa Loa (eye worm) pyruvate kinase-PB 0.0117 0.0139 0.0731
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0067 0.0067
Brugia malayi Pyruvate kinase, muscle isozyme 0.0167 0.0207 0.1079
Brugia malayi hypothetical protein 0.0022 0.0012 0.0055
Trypanosoma brucei unspecified product 0.0027 0.0019 0.072
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0009 0.0049
Schistosoma mansoni nuclear receptor 0.002 0.0009 0.0028
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0005 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0162 0.0844
Onchocerca volvulus 0.0042 0.0039 0.047
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0162 0.0844
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0005 0.0032
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0169 0.021 1
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.0162 0.0843
Schistosoma mansoni jumonji domain containing protein 0.006 0.0063 0.0312
Onchocerca volvulus 0.0073 0.0081 0.1129
Echinococcus multilocularis protein patched 0.0388 0.0505 0.0505
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0035 0.151
Mycobacterium ulcerans acyl-CoA synthetase 0.0218 0.0275 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0005 0.0005
Mycobacterium ulcerans pyruvate kinase 0.0167 0.0207 0.7474
Brugia malayi Nuclear hormone receptor E75 0.002 0.0009 0.0038
Mycobacterium ulcerans acetyl-CoA synthetase 0.0064 0.0069 0.2355
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0905 0.1199 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.013 0.0158 0.0828
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0045 0.0045
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0014 0.0352
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0012 0.0055
Schistosoma mansoni hypothetical protein 0.0374 0.0486 0.2567
Loa Loa (eye worm) hypothetical protein 0.0253 0.0323 0.1695
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0014 0.0463
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0154 0.0189 0.3053
Onchocerca volvulus 0.0492 0.0644 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0009 0.0009
Echinococcus multilocularis Niemann Pick C1 protein 0.0905 0.1199 0.1199
Giardia lamblia Macrophage migration inhibitory factor 0.0169 0.0209 0.9959
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0064 0.0069 0.1057
Plasmodium vivax phosphoglycerate kinase, putative 0.0169 0.021 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0066 0.3017
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0024
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0213 0.3259
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0081 0.3741
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0047 0.2082
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0065 0.0326
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0017 0.0006 0.0022
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0039 0.0039
Plasmodium vivax pyruvate kinase 2, putative 0.0086 0.0098 0.4551
Giardia lamblia Pyruvate kinase 0.0086 0.0098 0.4526
Onchocerca volvulus 0.0064 0.0069 0.0936
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0005
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.0111 0.0583
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0035 0.0473
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0213 0.3259
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0253 0.0323 0.1687
Onchocerca volvulus 0.02 0.0252 0.382
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0065 0.2967
Toxoplasma gondii patched family protein 0.0055 0.0056 0.2541
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.0334 0.515
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0014 0.0463
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0009 0.0266
Leishmania major acetyl-CoA synthetase, putative 0.0064 0.0069 0.2381
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0041 0.1768
Brugia malayi Phosphoglycerate kinase 0.0062 0.0066 0.0338
Brugia malayi beta-lactamase family protein 0.0073 0.0081 0.0415
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0005 0.0046
Mycobacterium tuberculosis Probable reductase 0.0109 0.0129 0.2058
Entamoeba histolytica hypothetical protein 0.0368 0.0478 0.3911
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0047 0.2082
Echinococcus granulosus dna polymerase eta 0.0065 0.007 0.0366
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.009 0.0474
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0065 0.2227
Mycobacterium ulcerans acyl-CoA synthetase 0.0064 0.0069 0.2355
Schistosoma mansoni pyruvate kinase 0.0167 0.0207 0.1083
Loa Loa (eye worm) hypothetical protein 0.0145 0.0178 0.0935
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0035 0.151
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0017 0.0006 0.0039
Leishmania major DNA polymerase eta, putative 0.0065 0.007 0.2422
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0096 0.0493
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0039 0.047
Trichomonas vaginalis antibiotic synthetase, putative 0.0064 0.0069 0.0998
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0009 0.0049
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0145064 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0073 0.0081 0.2833
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0061 0.0064 0.2929
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Brugia malayi Doublecortin family protein 0.002 0.0009 0.0039
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0049
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0055 0.0057 0.0859
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0045 0.0235
Echinococcus multilocularis GPCR, family 2 0.008 0.009 0.009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0077 0.0389
Schistosoma mansoni topbp1 0.0061 0.0064 0.0322
Brugia malayi hypothetical protein 0.002 0.0009 0.0039
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0081 0.0425
Echinococcus granulosus muscleblind protein 0.0145 0.0178 0.0935
Trichomonas vaginalis inositol monophosphatase, putative 0.0073 0.0081 0.1194
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0039 0.0187
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0035 0.0166
Brugia malayi Niemann-Pick C1 protein precursor 0.0905 0.1199 0.6293
Brugia malayi jmjC domain containing protein 0.0061 0.0065 0.0332
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0019 0.072
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0129 0.2058
Mycobacterium ulcerans acyl-CoA synthetase 0.0064 0.0069 0.2355
Brugia malayi jmjC domain containing protein 0.0016 0.0004 0.001
Leishmania major cytochrome p450-like protein 0.0017 0.0006 0.0074
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0006 0.0031
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0009 0.0049
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Treponema pallidum DNA ligase (lig) 0.0061 0.0064 0.2896
Echinococcus granulosus inositol monophosphatase 1 0.0073 0.0081 0.0426
Mycobacterium ulcerans acyl-CoA synthetase 0.0218 0.0275 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0067 0.3042
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0005 0.0016
Echinococcus multilocularis dna polymerase eta 0.0065 0.007 0.007
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0009 0.0049
Trypanosoma cruzi FHA domain containing protein, putative 0.0061 0.0064 0.2929
Schistosoma mansoni polycystin 1-related 0.002 0.0009 0.0029
Mycobacterium tuberculosis Conserved protein 0.0073 0.0081 0.1259
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0081 0.3728
Loa Loa (eye worm) pyruvate kinase 0.0035 0.003 0.0157
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0058 0.0303
Entamoeba histolytica hypothetical protein 0.0368 0.0478 0.3911
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0049
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0045 0.0235
Onchocerca volvulus 0.002 0.0009 0.0003
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0169 0.0209 0.9959
Entamoeba histolytica hypothetical protein 0.0368 0.0478 0.3911
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0004 0.0021
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0019 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0035 0.151
Leishmania major pyruvate kinase 0.0167 0.0207 0.7482
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0009 0.0049
Chlamydia trachomatis DNA ligase 0.0061 0.0064 0.2896
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0014 0.0507
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.0006 0.0097
Brugia malayi Patched family protein 0.0055 0.0056 0.0286
Schistosoma mansoni lamin 0.0027 0.0019 0.0079
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0129 0.2058
Echinococcus multilocularis pyruvate kinase 0.0132 0.016 0.016
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0213 0.3259
Onchocerca volvulus 0.0055 0.0056 0.0743
Echinococcus multilocularis inositol monophosphatase 1 0.0073 0.0081 0.0081
Leishmania major trypanothione reductase 0.0048 0.0047 0.1582
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0126
Toxoplasma gondii patched family protein 0.0055 0.0056 0.2541
Loa Loa (eye worm) hypothetical protein 0.0061 0.0064 0.0338
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0069 0.0351
Loa Loa (eye worm) inositol-1 0.0073 0.0081 0.0426
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0005 0.0046
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0046 0.0647
Echinococcus multilocularis sterol regulatory element binding protein 0.0388 0.0505 0.0505
Schistosoma mansoni lamin 0.0027 0.0019 0.0079
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0017 0.0006 0.0022
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0145064 0.5 0.5
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0081 0.278
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0005 0.0032
Loa Loa (eye worm) pyruvate kinase 0.0167 0.0207 0.1088
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0005 0.0046
Brugia malayi jmjC domain containing protein 0.006 0.0063 0.0319
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0064 0.0069 0.2325
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0017 0.0006 0.0022
Trichomonas vaginalis pyruvate kinase, putative 0.0167 0.0207 0.3167
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0017 0.0006 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0064 0.0932
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0017 0.0006 0.0097
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0017 0.0006 0.0039
Plasmodium vivax glutathione reductase, putative 0.0048 0.0047 0.2082
Schistosoma mansoni rab6-interacting 0.002 0.0009 0.0029
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Echinococcus multilocularis netrin receptor unc 5 0.0031 0.0024 0.0024
Onchocerca volvulus 0.0055 0.0056 0.0743
Schistosoma mansoni nuclear hormone receptor 0.002 0.0009 0.0028
Loa Loa (eye worm) hypothetical protein 0.0073 0.0081 0.0425
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0035 0.151
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0021
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0034 0.1434
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0129 0.2058
Treponema pallidum phosphoglycerate kinase 0.0169 0.021 1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0065 0.0326
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0004 0.0021
Echinococcus multilocularis microtubule associated protein 2 0.1412 0.1881 0.1881
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0012 0.0065
Brugia malayi ecdysteroid receptor 0.0042 0.0039 0.0195
Leishmania major phosphoglycerate kinase C, glycosomal 0.0169 0.021 0.7599
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0064 0.0069 0.036
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0064 0.0069 0.1057
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0005 0.0046
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0064 0.0069 0.3134
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0005 0.0046
Brugia malayi hypothetical protein 0.002 0.0009 0.0038
Onchocerca volvulus 0.0055 0.0056 0.0743
Trypanosoma brucei phosphoglycerate kinase, putative 0.0062 0.0066 0.3017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0039 0.0205
Brugia malayi beta-lactamase family protein 0.0073 0.0081 0.0415
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.009 0.0464
Echinococcus multilocularis replication factor c subunit 1 0.0061 0.0064 0.0064
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0145064 0.5 0.5
Loa Loa (eye worm) patched family protein 0.0055 0.0056 0.0296
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0064 0.0069 0.2355
Toxoplasma gondii patched family protein 0.0055 0.0056 0.2541
Brugia malayi Cytochrome P450 family protein 0.0026 0.0017 0.0082
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0009 0.0028
Trypanosoma brucei phosphoglycerate kinase 0.0062 0.0066 0.3017
Plasmodium vivax patched family protein, putative 0.0055 0.0056 0.2541
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Schistosoma mansoni cpg binding protein 0.0032 0.0026 0.0116
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0004 0.0004
Onchocerca volvulus 0.0055 0.0056 0.0743
Schistosoma mansoni intermediate filament proteins 0.0027 0.0019 0.0079
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0009 0.0028
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0017 0.0006 0.0039
Brugia malayi Patched family protein 0.0055 0.0056 0.0286
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0035 0.151
Trypanosoma cruzi pyruvate kinase 2, putative 0.0167 0.0207 0.9847
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0066 0.2293
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0035 0.0473
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0017 0.0006 0.0039
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0292 0.0374 0.1959
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0017 0.0006 0.0022
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0218 0.0275 1
Brugia malayi Patched family protein 0.0055 0.0056 0.0286
Brugia malayi hypothetical protein 0.0368 0.0478 0.2501
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.009 0.0474
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0039 0.0195
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0368 0.0478 0.2508
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0035 0.151
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0073 0.3327
Mycobacterium ulcerans acyl-CoA synthetase 0.0064 0.0069 0.2355
Brugia malayi AMP-binding enzyme family protein 0.0064 0.0069 0.0351
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0225 0.3453
Brugia malayi CHE-14 protein 0.0388 0.0505 0.2642
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0039 0.0205
Echinococcus multilocularis lamin 0.0027 0.0019 0.0019
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0064 0.0069 0.2355
Loa Loa (eye worm) hypothetical protein 0.0163 0.0201 0.1058
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0065 0.2255
Echinococcus multilocularis cpg binding protein 0.0034 0.0028 0.0028
Toxoplasma gondii thioredoxin reductase 0.0048 0.0047 0.2082
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0218 0.0275 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.0071 0.0363
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0205
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0002 0.001
Echinococcus granulosus methyl CpG binding domain protein 2 0.0052 0.0053 0.0277
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0014 0.0162
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0065
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0017 0.0006 0.0039
Schistosoma mansoni inositol monophosphatase 0.0073 0.0081 0.0411
Brugia malayi nuclear hormone receptor 0.002 0.0009 0.0038
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0205
Brugia malayi RNA binding protein 0.0134 0.0162 0.0843
Onchocerca volvulus Protein patched homolog 0.0055 0.0056 0.0743
Echinococcus multilocularis thyroid hormone receptor alpha 0.0172 0.0214 0.0214
Loa Loa (eye worm) RNA binding protein 0.0134 0.0162 0.0853
Schistosoma mansoni hypothetical protein 0.0173 0.0215 0.1125
Loa Loa (eye worm) oxidoreductase 0.0064 0.0069 0.036
Mycobacterium ulcerans hypothetical protein 0.0073 0.0081 0.2808
Echinococcus multilocularis Niemann Pick C1 protein 0.1293 0.1721 0.1721
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0047 0.2064
Entamoeba histolytica hypothetical protein 0.0061 0.0064 0.0422
Schistosoma mansoni patched 1 0.0388 0.0505 0.2667
Giardia lamblia Replication factor C, subunit 1 0.0061 0.0064 0.2897
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0081 0.041
Onchocerca volvulus Pyruvate kinase homolog 0.0167 0.0207 0.312
Brugia malayi Pax transcription activation domain interacting protein 0.0061 0.0064 0.0328
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0005 0.0046
Brugia malayi protein C24B5.3 0.0055 0.0056 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0039 0.0195
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0081 0.2843
Loa Loa (eye worm) cytochrome P450 0.0017 0.0006 0.0031
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Brugia malayi Cytochrome P450 family protein 0.0026 0.0017 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0064 0.0932
Brugia malayi nuclear receptor RXR 0.002 0.0009 0.0038
Loa Loa (eye worm) hypothetical protein 0.0073 0.0081 0.0425
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0035 0.151
Brugia malayi Patched family protein 0.0055 0.0056 0.0286
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0049
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0004 0.0021
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0368 0.0478 0.0478
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0017 0.0006 0.0039
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0205
Plasmodium falciparum lipid/sterol:H+ symporter 0.0055 0.0056 0.2541
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0009 0.0009
Echinococcus granulosus replication factor c subunit 1 0.0061 0.0064 0.0338
Echinococcus granulosus phd:f box containing protein 0.0016 0.0004 0.0021
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0039 0.0039
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0017 0.0006 0.0039
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0218 0.0275 1
Echinococcus multilocularis phosphoglycerate kinase 1 0.0169 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0173 0.0215 0.113
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.0162 0.0853
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0009 0.0009
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0111 0.519
Schistosoma mansoni acetyl-CoA synthetase 0.0064 0.0069 0.0345
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0009 0.0009
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0432 0.0563 0.2958
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0035 0.151
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0039 0.0195
Schistosoma mansoni hypothetical protein 0.0374 0.0486 0.2567
Brugia malayi glutathione reductase 0.0048 0.0047 0.0236
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0005 0.0046
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0064 0.0069 0.036
Echinococcus multilocularis musashi 0.0027 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Brugia malayi Protein kinase domain containing protein 0.0031 0.0024 0.0118
Loa Loa (eye worm) hypothetical protein 0.008 0.009 0.0474
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0014 0.0386
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0081 0.1194
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0017 0.0006 0.0074
Loa Loa (eye worm) hypothetical protein 0.0218 0.0275 0.1447
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0055 0.0291
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0064 0.0932
Echinococcus multilocularis 0.0017 0.0006 0.0006
Mycobacterium ulcerans phosphoglycerate kinase 0.0169 0.021 0.7591
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0039 0.0205
Brugia malayi cytochrome P450 0.0017 0.0006 0.0021
Plasmodium falciparum acyl-CoA synthetase 0.0163 0.0201 0.9572
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0052 0.0053 0.0053
Echinococcus granulosus microtubule associated protein 2 0.1412 0.1881 0.9877
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0169 0.0209 0.9959
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0039 0.0195
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0064 0.0069 0.2381
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0024 0.0126
Onchocerca volvulus 0.0055 0.0056 0.0743
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0064 0.0069 0.3134
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0017 0.0006 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0039 0.0205
Brugia malayi Bm-MIF-1, identical 0.0169 0.0209 0.1091
Brugia malayi AMP-binding enzyme family protein 0.0064 0.0069 0.0351
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0035 0.0035
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0031 0.0024 0.0126
Echinococcus multilocularis pyruvate kinase 0.0086 0.0098 0.0098
Mycobacterium tuberculosis Conserved protein 0.0073 0.0081 0.1259
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.0334 0.515
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0047 0.0246
Brugia malayi protein C24B5.3 0.0055 0.0056 0.0286
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0009 0.0009
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0146 0.2328
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0096 0.0502
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0017 0.0006 0.0039
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0006 0.0033
Echinococcus granulosus tar DNA binding protein 0.0134 0.0162 0.0853
Brugia malayi AMP-binding enzyme family protein 0.0064 0.0069 0.0351
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0035 0.1116
Schistosoma mansoni hypothetical protein 0.008 0.009 0.046
Brugia malayi Latrophilin receptor protein 2 0.008 0.009 0.0464
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0169 0.0209 0.3204
Toxoplasma gondii ATPase, AAA family protein 0.0061 0.0064 0.2929
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Trichomonas vaginalis pyruvate kinase, putative 0.0167 0.0207 0.3167
Echinococcus granulosus survival motor neuron protein 1 0.143 0.1904 1
Brugia malayi hypothetical protein 0.0055 0.0056 0.0286
Loa Loa (eye worm) hypothetical protein 0.0163 0.0201 0.1058
Loa Loa (eye worm) hypothetical protein 0.0163 0.0201 0.1058
Brugia malayi hypothetical protein 0.0055 0.0056 0.0286
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0167 0.0207 0.3343
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0017 0.0006 0.0022
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0006 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0039 0.0205
Brugia malayi Patched family protein 0.0055 0.0056 0.0286
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0041 0.0226
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0017 0.0657
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0039 0.0205
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0073 0.0081 0.3712
Onchocerca volvulus Protein patched homolog 0.0055 0.0056 0.0743
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0169 0.021 0.3217
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0064 0.0069 0.0069
Echinococcus granulosus intermediate filament protein 0.0027 0.0019 0.0098
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0154 0.0189 0.3053
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0039 0.0039
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0012 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0017 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0065
Entamoeba histolytica acyl-CoA synthetase, putative 0.0218 0.0275 0.2204
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0081 0.3728
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0064 0.0069 0.3134
Brugia malayi STAT protein, DNA binding domain containing protein 0.0136 0.0166 0.086
Giardia lamblia DINP protein human, muc B family 0.0039 0.0035 0.147
Brugia malayi DKFZp564C0469 protein 0.0061 0.0064 0.0328
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0039 0.0187
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Schistosoma mansoni netrin receptor unc5 0.0031 0.0024 0.0107
Brugia malayi Patched family protein 0.0055 0.0056 0.0286
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0017 0.0006 0.0022
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0012 0.0055
Onchocerca volvulus Glucosylceramidase homolog 0.0171 0.0213 0.3212
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0039 0.0195
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0169 0.021 0.7581
Brugia malayi tailless protein 0.002 0.0009 0.0038
Echinococcus multilocularis expressed conserved protein 0.085 0.1125 0.1125
Toxoplasma gondii hypothetical protein 0.0055 0.0056 0.2541
Brugia malayi Bromodomain containing protein 0.0058 0.0061 0.0308
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0178 0.0178
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0205
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0081 0.0081
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0169 0.021 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0218 0.0275 0.1447
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.0334 0.515
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0039 0.0205
Brugia malayi Patched family protein 0.0055 0.0056 0.0286
Brugia malayi Patched family protein 0.0055 0.0056 0.0286
Brugia malayi hypothetical protein 0.0061 0.0064 0.0328
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0064 0.0932
Schistosoma mansoni hypothetical protein 0.0349 0.0451 0.2382
Plasmodium falciparum macrophage migration inhibitory factor 0.0169 0.0209 0.9959
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0064 0.0069 0.3134
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.0111 0.0583
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0017 0.0006 0.0022
Echinococcus granulosus netrin receptor unc 5 0.0031 0.0024 0.0126
Leishmania major macrophage migration inhibitory factor-like protein 0.0169 0.0209 0.7568
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0045 0.0218
Trypanosoma cruzi DNA polymerase eta, putative 0.0065 0.007 0.3188
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0081 0.119
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0017 0.0006 0.0022
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0061 0.0064 0.0932
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0111 0.1662
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0005 0.0024
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0081 0.1194
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0031 0.0024 0.0024
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0065 0.0341
Onchocerca volvulus 0.0055 0.0056 0.0743
Entamoeba histolytica acyl-CoA synthetase, putative 0.0218 0.0275 0.2204
Echinococcus multilocularis Ankyrin 0.0031 0.0024 0.0024
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.0111 0.0574
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0045 0.0218
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0009 0.0038
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0073 0.0081 0.0563
Toxoplasma gondii pyruvate kinase PyK1 0.0167 0.0207 0.9847
Leishmania major phosphoglycerate kinase B, cytosolic 0.0169 0.021 0.7599
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0005 0.0035
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0218 0.0275 0.4472
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0005 0.0035
Schistosoma mansoni transcription factor LCR-F1 0.0368 0.0478 0.2524
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.0111 0.0816
Echinococcus granulosus RUN 0.002 0.0009 0.0049
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0111 0.1662
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0005 0.0046
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0012 0.0065
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0047 0.2064
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0009 0.0049
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0111 0.1662
Schistosoma mansoni hypothetical protein 0.0031 0.0024 0.0107
Brugia malayi Cytochrome P450 family protein 0.0055 0.0056 0.0286
Schistosoma mansoni kinase 0.0049 0.0048 0.0234
Plasmodium vivax SET domain protein, putative 0.0063 0.0067 0.3042
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0039 0.0039
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0004 0.0004
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0017 0.0006 0.0039
Leishmania major acetyl-CoA synthetase, putative 0.0064 0.0069 0.2381
Brugia malayi pyruvate kinase 0.0035 0.003 0.0147
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0205
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0017 0.0006 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0039 0.0205
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0065 0.0326
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0035 0.0503
Onchocerca volvulus 0.0032 0.0026 0.0259
Schistosoma mansoni survival motor neuron protein 0.0292 0.0374 0.1975
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0017 0.0006 0.0039
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0111 0.1662
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0061 0.0064 0.2929
Echinococcus granulosus lamin 0.0027 0.0019 0.0098
Schistosoma mansoni pyruvate kinase 0.0167 0.0207 0.1083
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0039 0.0205
Plasmodium vivax pyruvate kinase, putative 0.0167 0.0207 0.9847
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0039 0.0187
Loa Loa (eye worm) hypothetical protein 0.0061 0.0064 0.0338
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0067 0.0334
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0047 0.0698
Mycobacterium ulcerans acyl-CoA synthetase 0.0218 0.0275 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0081 0.2808
Schistosoma mansoni DNA polymerase eta 0.0065 0.007 0.0351
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0071 0.0372
Loa Loa (eye worm) hypothetical protein 0.0064 0.0069 0.036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0039 0.0195
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0115 0.0137 0.0137
Brugia malayi Patched family protein 0.0055 0.0056 0.0286
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.009 0.0474
Loa Loa (eye worm) patched family protein 0.0055 0.0056 0.0296
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0081 0.1259
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0035 0.151
Onchocerca volvulus Pyruvate kinase homolog 0.0167 0.0207 0.312
Schistosoma mansoni nuclear hormone receptor 0.002 0.0009 0.0028
Brugia malayi Patched family protein 0.0055 0.0056 0.0286
Leishmania major DNA polymerase eta, putative 0.0038 0.0034 0.109
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.009 0.009
Loa Loa (eye worm) pyruvate kinase 0.0167 0.0207 0.1088
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0066 0.3017
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0009 0.0049
Plasmodium falciparum phosphoglycerate kinase 0.0169 0.021 1
Brugia malayi Patched related family protein 10 0.0055 0.0056 0.0286
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0146 0.2328
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0169 0.021 0.3396
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0081 0.3728
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.0296
Schistosoma mansoni phosphoglycerate kinase 0.0169 0.021 0.11
Entamoeba histolytica acyl-coA synthetase, putative 0.0218 0.0275 0.2204
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0049
Echinococcus multilocularis RUN 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0064 0.0069 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0388 0.0505 0.7825
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0154 0.0189 0.3053
Schistosoma mansoni ankyrin 23/unc44 0.0031 0.0024 0.0107
Mycobacterium leprae Probable pyruvate kinase PykA 0.0167 0.0207 0.7464
Schistosoma mansoni thyroid hormone receptor 0.0172 0.0214 0.112
Schistosoma mansoni chromosome transmission fidelity factor 0.0061 0.0064 0.0322
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0006 0.0006
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0253 0.0323 0.1695
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0035 0.1116
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.0334 0.515
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.009 0.009
Echinococcus granulosus Niemann Pick C1 protein 0.1293 0.1721 0.9038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0039 0.0205
Loa Loa (eye worm) DR-78 0.002 0.0009 0.0049
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0066 0.3017
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0081 0.1259
Onchocerca volvulus 0.0027 0.0019 0.0149
Brugia malayi Patched family protein 0.0055 0.0056 0.0286
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.0334 0.515
Leishmania major DNA polymerase kappa, putative 0.0039 0.0035 0.1147
Schistosoma mansoni topbp1 0.0061 0.0064 0.0322
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0005 0.0032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0039 0.0039
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0045 0.0225
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0039 0.0195
Echinococcus multilocularis pyruvate kinase 0.0167 0.0207 0.0207
Schistosoma mansoni coup transcription factor 0.0042 0.0039 0.0187
Echinococcus multilocularis dnaJ subfamily B 0.0457 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0169 0.021 0.1104

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.9 uM Antileishmanial activity against Leishmania braziliensis MHOM/BR/00/LTB300 promastigotes assessed as parasite viability after 5 days by MTT assay ChEMBL. 19837489
IC50 (functional) = 1 uM Antitrypanosomal activity against Trypanosoma cruzi CL Brener epimastigotes assessed as parasite viability after 5 days by MTT assay ChEMBL. 19837489
IC50 (functional) = 1.9 uM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as parasite growth inhibition after 5 days ChEMBL. 19837489
Ratio IC50 (functional) = 10 Ratio of compound IC50 to Miltefosine IC50 for Leishmania braziliensis MHOM/BR/00/LTB300 promastigotes ChEMBL. 19837489

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Leishmania braziliensis ChEMBL23 19837489
Trypanosoma cruzi ChEMBL23 19837489

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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