Detailed information for compound 1095109

Basic information

Technical information
  • TDR Targets ID: 1095109
  • Name: 3-(4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl )propan-1-one
  • MW: 330.375 | Formula: C19H22O5
  • H donors: 0 H acceptors: 1 LogP: 3.38 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CCC(=O)c1cc(OC)c(c(c1)OC)OC
  • InChi: 1S/C19H22O5/c1-21-15-8-5-13(6-9-15)7-10-16(20)14-11-17(22-2)19(24-4)18(12-14)23-3/h5-6,8-9,11-12H,7,10H2,1-4H3
  • InChiKey: FARTWAUUUXFSFV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • NSC96357

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0017 0.0006 0.002
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0044 0.0865
Entamoeba histolytica cysteine protease, putative 0.0017 0.0006 0.0704
Entamoeba histolytica cysteine protease, putative 0.0091 0.0082 1
Onchocerca volvulus Cathepsin L homolog 0.0091 0.0082 0.0076
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0017 0.0006 0.002
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0028 0.0103
Echinococcus multilocularis lamin dm0 0.0081 0.0073 0.0246
Onchocerca volvulus 0.0091 0.0082 0.0076
Echinococcus multilocularis survival motor neuron protein 1 0.0768 0.0782 0.2667
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0001 0.0015
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0001 0.0002
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.0161 0.0155
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0017 0.0006 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0161 0.3181
Loa Loa (eye worm) RecQ helicase 0.0023 0.0012 0.0151
Brugia malayi Bromodomain containing protein 0.0029 0.0018 0.0025
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0018 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0082 0.1616
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0017 0.0006 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0017 0.0006 0.0105
Entamoeba histolytica cysteine protease, putative 0.0047 0.0037 0.4473
Echinococcus multilocularis GPCR, family 2 0.0143 0.0137 0.0465
Onchocerca volvulus 0.0091 0.0082 0.0076
Brugia malayi jmjC domain containing protein 0.0027 0.0017 0.0023
Plasmodium vivax JmjC domain containing protein 0.0027 0.0017 0.0061
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0315 0.0314 0.1152
Plasmodium vivax vivapain-3 0.0047 0.0037 0.0135
Schistosoma mansoni protein phosphatase 2C 0.0027 0.0017 0.0057
Leishmania major beta tubulin 0.003 0.0019 0.0069
Echinococcus multilocularis beta tubulin 0.003 0.0019 0.0064
Brugia malayi hypothetical protein 0.0139 0.0132 0.0181
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0 0.0002
Loa Loa (eye worm) papain family cysteine protease containing protein 0.003 0.0019 0.0247
Toxoplasma gondii alpha tubulin TUBA1 0.0012 0 0.0002
Brugia malayi cathepsin Z-like cysteine proteinase 0.0017 0.0006 0.0008
Echinococcus granulosus lamin 0.0081 0.0073 0.0246
Echinococcus granulosus tubulin subunit beta 0.003 0.0019 0.0064
Schistosoma mansoni hypothetical protein 0.0552 0.0558 0.1905
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0012 1
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0055 0.0187
Plasmodium vivax vivapain-2 0.0091 0.0082 0.0301
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0017 0.0006 0.0105
Trypanosoma cruzi major cysteine proteinase, putative 0.0271 0.0269 0.0986
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0001 0.0002
Brugia malayi cathepsin B-like cysteine proteinase 0.0017 0.0006 0.0008
Trypanosoma brucei beta tubulin 0.003 0.0019 0.0069
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0014 0.0172
Brugia malayi Cathepsin L-like precursor 0.0091 0.0082 0.0113
Echinococcus multilocularis tubulin, beta 4A class IVa 0.003 0.0019 0.0064
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0023 0.0012 0.0039
Loa Loa (eye worm) latrophilin receptor protein 2 0.0143 0.0137 0.1746
Echinococcus granulosus transient receptor potential gamma protein 0.0096 0.0087 0.0297
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0044 0.0161
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0015 0.0004 0.0569
Loa Loa (eye worm) hypothetical protein 0.0061 0.0051 0.0653
Plasmodium falciparum glutathione reductase 0.0015 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.031 0.0309 0.3945
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0004 0.0012
Schistosoma mansoni phd/f-box containing protein 0.0027 0.0017 0.0057
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0055 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0231
Trypanosoma brucei trypanothione reductase 0.0043 0.0033 0.0119
Giardia lamblia Beta tubulin 0.003 0.0019 0.0069
Plasmodium falciparum telomerase reverse transcriptase 0.2648 0.2723 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0018 0.0062
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0015 0.0004 0.0569
Toxoplasma gondii alpha-tubulin I, putative 0.0012 0 0.0002
Brugia malayi Cathepsin L-like precursor 0.0091 0.0082 0.0113
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0015 0.0004 0.0547
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0105
Schistosoma mansoni tubulin subunit beta 0.003 0.0019 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0252 0.4972
Mycobacterium tuberculosis Probable dehydrogenase 0.0098 0.0089 0.8837
Echinococcus granulosus jumonji domain containing protein 0.004 0.003 0.01
Echinococcus multilocularis beta tubulin 0.003 0.0019 0.0064
Schistosoma mansoni cathepsin C 0.0017 0.0006 0.002
Loa Loa (eye worm) hypothetical protein 0.0768 0.0782 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0091 0.0082 0.0301
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0001 0.0002
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0046 0.0582
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.044 0.0443 0.5663
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0103
Plasmodium vivax unspecified product 0.003 0.0019 0.0071
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.2648 0.2723 1
Schistosoma mansoni cpg binding protein 0.0034 0.0024 0.0082
Loa Loa (eye worm) hypothetical protein 0.0036 0.0025 0.0322
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0345 0.0345 0.1266
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.0082 0.1616
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0055 0.02
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0255 0.0252 0.0346
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0143 0.0137 0.0465
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0162 0.0155 0.0529
Onchocerca volvulus Huntingtin homolog 0.0139 0.0132 0.0126
Leishmania major beta tubulin 0.003 0.0019 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0082 0.1616
Brugia malayi cathepsin F-like cysteine proteinase 0.0017 0.0006 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0345 0.0345 0.1266
Plasmodium vivax tubulin beta chain, putative 0.003 0.0019 0.0071
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0015 0.0004 0.0547
Schistosoma mansoni hypothetical protein 0.0143 0.0137 0.0466
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0012 0.0042
Toxoplasma gondii RNA-directed DNA polymerase 0.2648 0.2723 1
Echinococcus multilocularis cysteine protease 0.0091 0.0082 0.0279
Brugia malayi jmjC domain containing protein 0.0162 0.0155 0.0214
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0012 0.0045
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0037 0.0125
Loa Loa (eye worm) intermediate filament protein 0.0081 0.0073 0.0927
Onchocerca volvulus 0.0202 0.0197 0.0192
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0072
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0062 0.0212
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0044 0.016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0105
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0004 0.0012
Entamoeba histolytica cysteine protease, putative 0.0017 0.0006 0.0704
Trypanosoma brucei beta tubulin 0.003 0.0019 0.0069
Loa Loa (eye worm) hypothetical protein 0.0096 0.0087 0.1116
Giardia lamblia Cathepsin B precursor 0.0017 0.0006 0.0019
Giardia lamblia DINP protein human, muc B family 0.0039 0.0028 0.0103
Entamoeba histolytica tubulin family protein 0.003 0.0019 0.235
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0017 0.0006 0.0019
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0015 0.0004 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0161 0.3181
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0006 0.0008
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0012 0.0044
Loa Loa (eye worm) tubulin beta-2A chain 0.003 0.0019 0.0245
Schistosoma mansoni alpha tubulin 0.0012 0 0.0002
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0028 0.0103
Loa Loa (eye worm) fibroinase 0.0091 0.0082 0.1048
Plasmodium vivax tubulin alpha chain, putative 0.0012 0 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0082 0.1616
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0012 0.0043
Plasmodium falciparum tubulin beta chain 0.003 0.0019 0.007
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0231
Schistosoma mansoni hypothetical protein 0.031 0.0309 0.1053
Loa Loa (eye worm) hypothetical protein 0.0038 0.0028 0.0351
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0162 0.0155 0.0529
Schistosoma mansoni tubulin subunit gamma 0.0012 0 0.0002
Echinococcus granulosus dna polymerase eta 0.0039 0.0028 0.0095
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0042 0.0142
Plasmodium vivax DNA repair protein REV1, putative 0.0012 0.0001 0.0003
Onchocerca volvulus Cathepsin F homolog 0.0091 0.0082 0.0076
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.0004 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0082 0.1616
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0072
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0015 0.0004 0.0569
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0015 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.003 0.0019 0.0247
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0015 0.0004 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0161 0.3181
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0016 0.0057
Schistosoma mansoni hypothetical protein 0.0157 0.015 0.0513
Echinococcus multilocularis phd:f box containing protein 0.0027 0.0017 0.0055
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0015 0.0004 0.0012
Treponema pallidum NADH oxidase 0.0015 0.0004 0.286
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0012 0.0016
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0028 0.3463
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0012 0.0044
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0004 0.0012
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0004 0.0013
Plasmodium falciparum alpha tubulin 2 0.0012 0 0.0001
Schistosoma mansoni tubulin subunit beta 0.003 0.0019 0.0066
Leishmania major beta tubulin 0.003 0.0019 0.0069
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0015 0.0004 0.0012
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0017 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0103
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0051 0.0173
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.0082 0.1616
Toxoplasma gondii cathepsin CPC1 0.0017 0.0006 0.0021
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0098 0.0089 0.8837
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.0082 0.1616
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0017 0.0006 0.0105
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0029 0.0098
Loa Loa (eye worm) tubulin beta chain 0.003 0.0019 0.0245
Brugia malayi Cathepsin L-like cysteine proteinase 0.0061 0.0051 0.007
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0027 0.0017 0.0057
Echinococcus multilocularis tubulin subunit beta 0.003 0.0019 0.0064
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0015 0.0004 0.0012
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0037 0.005
Giardia lamblia Cysteine protease 0.0017 0.0006 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0082 0.1616
Leishmania major beta tubulin 0.003 0.0019 0.0069
Entamoeba histolytica cysteine protease, putative 0.0047 0.0037 0.4473
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0015 0.0004 0.0012
Trypanosoma cruzi DNA polymerase eta, putative 0.0012 0.0001 0.0002
Trypanosoma brucei unspecified product 0.0027 0.0016 0.0057
Trypanosoma cruzi cysteine peptidase, putative 0.0345 0.0345 0.1266
Giardia lamblia Cathepsin B precursor 0.0017 0.0006 0.0019
Echinococcus granulosus beta tubulin 0.003 0.0019 0.0064
Leishmania major beta tubulin 0.003 0.0019 0.0069
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0252 0.4972
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0001 0.0003
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0017 0.0006 0.0704
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0345 0.0345 0.1266
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0109 0.0101 1
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0028 0.5105
Onchocerca volvulus 0.0091 0.0082 0.0076
Brugia malayi Cytochrome P450 family protein 0.0055 0.0046 0.0063
Echinococcus granulosus Tubulin beta 2C chain 0.003 0.0019 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0082 0.1616
Trypanosoma brucei beta tubulin 0.003 0.0019 0.0069
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0001 0.0002
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0044 0.0149
Schistosoma mansoni hypothetical protein 0.0464 0.0467 0.1595
Leishmania major cytochrome p450-like protein 0.0015 0.0004 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.0082 0.1616
Leishmania major beta tubulin 0.003 0.0019 0.0069
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0054 0.0185
Echinococcus multilocularis cathepsin b 0.0017 0.0006 0.0018
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0.0019 0.0064
Schistosoma mansoni tubulin subunit alpha 0.0012 0 0.0002
Echinococcus multilocularis musashi 0.0081 0.0073 0.0246
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0161 0.3181
Echinococcus granulosus GPCR family 2 0.0143 0.0137 0.0465
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0055 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.0037 0.4473
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0034 0.0427
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0017 0.0006 0.002
Loa Loa (eye worm) hypothetical protein 0.0082 0.0073 0.0935
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0044 0.016
Plasmodium falciparum JmjC domain-containing protein, putative 0.0027 0.0017 0.006
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0004 0.0013
Schistosoma mansoni jumonji/arid domain-containing protein 0.0104 0.0096 0.0327
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0028 0.0103
Giardia lamblia Cathepsin L precursor 0.0017 0.0006 0.0019
Loa Loa (eye worm) tubulin alpha chain 0.0012 0 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0161 0.3181
Brugia malayi cathepsin L-like precursor 0.0061 0.0051 0.007
Plasmodium falciparum cysteine proteinase falcipain 3 0.0091 0.0082 0.0301
Echinococcus granulosus cathepsin L 0.0017 0.0006 0.0018
Plasmodium vivax unspecified product 0.0017 0.0006 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0345 0.0345 0.1266
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.0014 0.2344
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0018 0.0067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0345 0.0345 0.1266
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0017 0.0006 0.0704
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0143 0.0137 0.0188
Echinococcus multilocularis cathepsin L cysteine protease 0.0091 0.0082 0.0279
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0015 0.0004 0.0569
Onchocerca volvulus Huntingtin homolog 0.0139 0.0132 0.0126
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0044 0.0161
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0028 0.0362
Leishmania major cathepsin L-like protease 0.0091 0.0082 0.03
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0103
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.017 0.3365
Schistosoma mansoni transient receptor potential channel 0.0096 0.0087 0.0298
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0345 0.0345 0.1266
Plasmodium falciparum serine repeat antigen 2 0.0017 0.0006 0.002
Plasmodium vivax vivapain-1 0.0047 0.0037 0.0135
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0018 0.0066
Leishmania major cytochrome p450-like protein 0.0015 0.0004 0.0013
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0044 0.0563
Leishmania major cysteine peptidase A (CPA) 0.0091 0.0082 0.03
Trypanosoma cruzi cruzipain precursor, putative 0.003 0.0019 0.007
Brugia malayi Cathepsin L-like precursor 0.0061 0.0051 0.007
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0091 0.0082 0.1048
Schistosoma mansoni tubulin subunit epsilon 0.0012 0 0.0002
Schistosoma mansoni tubulin subunit beta 0.003 0.0019 0.0066
Loa Loa (eye worm) tubulin gamma chain 0.0012 0 0.0005
Schistosoma mansoni alpha tubulin 0.0012 0 0.0002
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0012 0.0864
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0015 0.0004 0.0569
Trichomonas vaginalis tubulin epsilon chain, putative 0.003 0.0019 0.0372
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0042 0.0536
Schistosoma mansoni tubulin subunit beta 0.003 0.0019 0.0066
Giardia lamblia Cathepsin L precursor 0.0017 0.0006 0.0019
Schistosoma mansoni cathepsin s 0.003 0.0019 0.0066
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0055 0.526
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0028 0.0553
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0004 0.0012
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0034 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0105
Echinococcus granulosus microtubule associated protein 2 0.2848 0.293 1
Schistosoma mansoni DNA helicase recq1 0.0023 0.0012 0.0041
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0012 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.0037 0.4473
Echinococcus granulosus beta tubulin 0.003 0.0019 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0105
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0028 0.0553
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0143 0.0137 0.0465
Giardia lamblia Cathepsin B precursor 0.0017 0.0006 0.0019
Echinococcus granulosus protection of telomeres protein 1 0.0547 0.0553 0.1888
Plasmodium vivax glutathione reductase, putative 0.0043 0.0033 0.012
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0028 0.0097
Leishmania major cathepsin L-like protease 0.0345 0.0345 0.1266
Echinococcus granulosus lysine specific demethylase 6a 0.0027 0.0017 0.0055
Echinococcus granulosus dna polymerase kappa 0.0039 0.0028 0.0095
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0044 0.016
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0028 0.2536
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.0033 0.012
Onchocerca volvulus 0.0033 0.0022 0.0016
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0004 0.0067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0054 0.0185
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0037 0.0133
Trypanosoma cruzi major cysteine proteinase, putative 0.0017 0.0006 0.002
Echinococcus granulosus cathepsin L cysteine proteinase 0.0091 0.0082 0.0279
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0015 0.0004 0.0547
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0001 0.0003
Plasmodium vivax vivapain-2 0.0091 0.0082 0.0301
Toxoplasma gondii cathepsin B 0.0017 0.0006 0.0021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.001
Plasmodium falciparum serine repeat antigen 1 0.0017 0.0006 0.002
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0028 0.0095
Loa Loa (eye worm) hypothetical protein 0.0027 0.0017 0.0211
Onchocerca volvulus 0.0157 0.015 0.0145
Loa Loa (eye worm) cytochrome P450 0.0015 0.0004 0.0049
Onchocerca volvulus 0.0091 0.0082 0.0076
Entamoeba histolytica tubulin gamma chain 0.0012 0 0.0059
Schistosoma mansoni DNA polymerase eta 0.0039 0.0028 0.0097
Plasmodium falciparum phd finger protein, putative 0.0029 0.0018 0.0066
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0017 0.0006 0.0021
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0006 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0051 0.1003
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0017 0.0006 0.002
Schistosoma mansoni hypothetical protein 0.0108 0.01 0.0341
Brugia malayi hypothetical protein 0.0019 0.0008 0.001
Brugia malayi fibroinase precursor 0.0017 0.0006 0.0008
Echinococcus multilocularis cathepsin L cysteine protease 0.0091 0.0082 0.0279
Leishmania major beta tubulin 0.003 0.0019 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0103
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0018 0.0067
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0025 0.0035
Leishmania major beta tubulin 0.003 0.0019 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0103
Brugia malayi Cathepsin L-like precursor 0.0091 0.0082 0.0113
Plasmodium vivax serine-repeat antigen (SERA) 0.0017 0.0006 0.0021
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.257 0.2643 0.902
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0037 0.0133
Loa Loa (eye worm) alpha-tubulin 0.0012 0 0.0005
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0006 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0161 0.3181
Brugia malayi hypothetical protein 0.0108 0.01 0.0137
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0015 0.0004 0.0012
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0006 0.002
Echinococcus granulosus Tubulin beta 2C chain 0.003 0.0019 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0252 0.4972
Onchocerca volvulus 0.0091 0.0082 0.0076
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0017 0.0006 0.0019
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0157 0.015 0.0207
Leishmania major beta tubulin 0.003 0.0019 0.0069
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0023 0.0012 0.0043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0042 0.0143
Echinococcus granulosus cathepsin L 0.0047 0.0037 0.0124
Plasmodium falciparum thioredoxin reductase 0.0015 0.0004 0.0013
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0012 0.0045
Leishmania major DNA polymerase kappa, putative 0.0012 0.0001 0.0002
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0055 0.0186
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0017 0.0006 0.0105
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0001 0.0002
Schistosoma mansoni survival motor neuron protein 0.0157 0.015 0.0513
Echinococcus granulosus cpg binding protein 0.0034 0.0024 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0017 0.0006 0.0105
Schistosoma mansoni cathepsin F (C01 family) 0.0091 0.0082 0.028
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0018 0.0067
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0017 0.0006 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0082 0.1616
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0025 0.0085
Loa Loa (eye worm) hypothetical protein 0.003 0.0019 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0017 0.0006 0.0105
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0042 0.0142
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0345 0.0345 0.1266
Echinococcus multilocularis lysine specific demethylase 6a 0.0027 0.0017 0.0055
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0054 0.0182
Echinococcus granulosus tumor protein p63 0.1381 0.1415 0.4827
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0004 0.0013
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0017 0.0006 0.002
Schistosoma mansoni jumonji/arid domain-containing protein 0.0104 0.0096 0.0327
Leishmania major cathepsin L-like protease 0.0091 0.0082 0.03
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0072
Loa Loa (eye worm) BEN-1 protein 0.003 0.0019 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0082 0.1616
Echinococcus multilocularis protection of telomeres protein 1 0.0547 0.0553 0.1888
Brugia malayi Pre-SET motif family protein 0.0064 0.0054 0.0075
Echinococcus multilocularis transient receptor potential gamma protein 0.0096 0.0087 0.0297
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0103
Brugia malayi jmjC domain containing protein 0.0027 0.0017 0.0023
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0029 0.0019 0.0062
Plasmodium vivax telomerase reverse transcriptase, putative 0.2648 0.2723 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0004 0.0012
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0004 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0042 0.0143
Giardia lamblia Cysteine protease 0.0017 0.0006 0.0019
Toxoplasma gondii preprocathepsin c precursor, putative 0.0017 0.0006 0.0021
Onchocerca volvulus 0.0091 0.0082 0.0076
Loa Loa (eye worm) hypothetical protein 0.0108 0.01 0.1278
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.0051 0.6231
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0017 0.0006 0.002
Trypanosoma cruzi cysteine peptidase, putative 0.0345 0.0345 0.1266
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0042 0.0142
Leishmania major beta tubulin 0.003 0.0019 0.0069
Echinococcus granulosus geminin 0.0552 0.0558 0.1904
Brugia malayi cathepsin L precursor 0.0017 0.0006 0.0008
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0012 0.0227
Giardia lamblia Cathepsin B precursor 0.0017 0.0006 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0345 0.0345 0.1266
Leishmania major cathepsin L-like protease 0.0091 0.0082 0.03
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0012 0.212
Brugia malayi hypothetical protein 0.0108 0.01 0.0137
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0073 0.0101
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0015 0.0004 0.0012
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0.0019 0.0064
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0037 0.0133
Brugia malayi Thioredoxin reductase 0.0043 0.0033 0.0045
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0054 0.0199
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.0001 0.0002
Leishmania major beta tubulin 0.003 0.0019 0.0069
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0012 0.0044
Trypanosoma cruzi beta tubulin, putative 0.003 0.0019 0.0069
Brugia malayi glutathione reductase 0.0043 0.0033 0.0045
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0025 0.0085
Loa Loa (eye worm) hypothetical protein 0.0143 0.0137 0.1746
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0017 0.0006 0.0021
Loa Loa (eye worm) hypothetical protein 0.0202 0.0197 0.2521
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0015 0.0004 0.0569
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0015 0.0004 0.0569
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0453 0.0457 0.5839
Giardia lamblia Hypothetical protein 0.0017 0.0006 0.0019
Brugia malayi latrophilin 2 splice variant baaae 0.031 0.0309 0.0424
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0006 0.0105
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0015 0.0004 0.0569
Entamoeba histolytica tubulin alpha-1 chain 0.0012 0 0.0059
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0044 0.0865
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0012 0.212
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0028 0.0039
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0015 0.0004 0.0012
Trypanosoma brucei beta tubulin 0.003 0.0019 0.0069
Onchocerca volvulus 0.0091 0.0082 0.0076
Leishmania major beta tubulin 0.003 0.0019 0.0069
Echinococcus granulosus lysine specific demethylase 5A 0.0104 0.0096 0.0326
Trichomonas vaginalis set domain proteins, putative 0.0501 0.0506 1
Giardia lamblia Cathepsin L precursor 0.0017 0.0006 0.0019
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0001 0.0002
Echinococcus multilocularis dna polymerase eta 0.0039 0.0028 0.0095
Loa Loa (eye worm) hypothetical protein 0.0453 0.0457 0.5839
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0001 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0017 0.0006 0.0105
Loa Loa (eye worm) hypothetical protein 0.008 0.0071 0.0907
Plasmodium falciparum DNA repair protein REV1, putative 0.0012 0.0001 0.0002
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0004 0.0012
Leishmania major DNA polymerase kappa, putative 0.0039 0.0028 0.0103
Loa Loa (eye worm) tubulin alpha chain 0.0012 0 0.0005
Schistosoma mansoni cathepsin B (C01 family) 0.0017 0.0006 0.002
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0098 0.0089 0.8837
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0004 0.0014
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0004 0.0012
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0091 0.0082 0.0279
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0015 0.0004 0.0012
Entamoeba histolytica recQ family DNA helicase 0.0012 0 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0082 0.1616
Schistosoma mansoni hypothetical protein 0.0015 0.0004 0.0014
Giardia lamblia Cathepsin B precursor 0.0017 0.0006 0.0019
Schistosoma mansoni hypothetical protein 0.0013 0.0002 0.0006
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0028 0.0095
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0252 0.4972
Leishmania major beta tubulin 0.003 0.0019 0.0069
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0081 0.0073 0.0927
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.0033 0.0418
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0055 0.0186
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0023 0.0012 0.0039
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0004 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0054 0.0185
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0017 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.0039 0.0029 0.037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0345 0.0345 0.1266
Giardia lamblia Hypothetical protein 0.0017 0.0006 0.0019
Toxoplasma gondii beta tubulin 0.003 0.0019 0.0071
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0033 0.0112
Giardia lamblia Cathepsin L precursor 0.0017 0.0006 0.0019
Plasmodium vivax hypothetical protein, conserved 0.0011 0 0.0001
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0015 0.0004 0.0569
Giardia lamblia PHD finger protein 15 0.0029 0.0018 0.0065
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0028 0.0103
Entamoeba histolytica cysteine protease, putative 0.0017 0.0006 0.0704
Echinococcus granulosus dnaJ subfamily B 0.0464 0.0467 0.1593
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.0082 0.1616
Echinococcus granulosus bloom syndrome protein 0.0023 0.0012 0.0039
Schistosoma mansoni cpg binding protein 0.0033 0.0022 0.0075
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0037 0.4473
Echinococcus multilocularis jumonji domain containing 1A 0.0027 0.0017 0.0055
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0023 0.0012 0.0039
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0012 0.0044
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0012 0.0227
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0012 0.0875
Plasmodium falciparum cysteine proteinase falcipain 1 0.0047 0.0037 0.0134
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0161 0.3181
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0028 0.0095
Entamoeba histolytica cysteine proteinase 2 0.0047 0.0037 0.4473
Trypanosoma brucei telomerase reverse transcriptase 0.2648 0.2723 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0044 0.0149
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0012 0.0042
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0037 0.4473
Loa Loa (eye worm) hypothetical protein 0.0108 0.01 0.1278
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0004 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0044 0.0151
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0012 0.0016
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0072
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0015 0.0004 0.0012
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0029 0.0098
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0255 0.0252 0.3217
Entamoeba histolytica cysteine proteinase, putative 0.0091 0.0082 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0004 0.0012
Schistosoma mansoni transient receptor potential channel 4 0.0096 0.0087 0.0298
Brugia malayi intermediate filament protein 0.0081 0.0073 0.01
Giardia lamblia Telomerase catalytic subunit 0.2648 0.2723 1
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0028 0.0039
Brugia malayi PHD-finger family protein 0.0029 0.0018 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0105
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.2648 0.2723 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0027 0.0017 0.0059
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0011 0.0015
Entamoeba histolytica cysteine protease, putative 0.0017 0.0006 0.0704
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0001 0.0002
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0037 0.4473
Trypanosoma brucei protein kinase, putative 0.0054 0.0044 0.016
Brugia malayi Cathepsin L-like precursor 0.0091 0.0082 0.0113
Plasmodium vivax tubulin alpha chain, putative 0.0012 0 0.0002
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0012 0.0227
Echinococcus granulosus intermediate filament protein 0.0081 0.0073 0.0246
Entamoeba histolytica cysteine protease, putative 0.0047 0.0037 0.4473
Entamoeba histolytica hypothetical protein 0.0023 0.0012 0.1502
Onchocerca volvulus Cathepsin L homolog 0.0091 0.0082 0.0076
Entamoeba histolytica cysteine protease, putative 0.0047 0.0037 0.4473
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0082 0.1616
Echinococcus granulosus cathepsin b 0.0017 0.0006 0.0018
Onchocerca volvulus 0.0081 0.0073 0.0067
Brugia malayi Cathepsin L-like precursor 0.0091 0.0082 0.0113
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0109 0.0101 1
Giardia lamblia Encystation-specific protease 0.0017 0.0006 0.0019
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0006 0.0072
Loa Loa (eye worm) BEN-1 protein 0.003 0.0019 0.0245
Leishmania major DNA damage repair protein, putative 0.0012 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0064 0.0054 0.0693
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0044 0.0162
Trypanosoma cruzi cysteine peptidase, putative 0.0091 0.0082 0.03
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0018 0.0061
Loa Loa (eye worm) hypothetical protein 0.003 0.0019 0.0247
Entamoeba histolytica cysteine protease, putative 0.0017 0.0006 0.0704
Brugia malayi Pre-SET motif family protein 0.044 0.0443 0.0609
Loa Loa (eye worm) hypothetical protein 0.0061 0.0051 0.0653
Echinococcus multilocularis tubulin beta 1 chain 0.003 0.0019 0.0064
Leishmania major hypothetical protein, conserved 0.0027 0.0017 0.0059
Echinococcus multilocularis lamin 0.0081 0.0073 0.0246
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.0004
Entamoeba histolytica cysteine protease, putative 0.0047 0.0037 0.4473
Loa Loa (eye worm) alpha-tubulin 0.0012 0 0.0005
Brugia malayi Cathepsin L-like precursor 0.003 0.0019 0.0027
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0006 0.002
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0004 0.0012
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0054 0.0184
Brugia malayi Cathepsin L-like precursor 0.0091 0.0082 0.0113
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0006 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0004 0.0012
Schistosoma mansoni cathepsin F (C01 family) 0.0091 0.0082 0.028
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.005 0.0636
Entamoeba histolytica tubulin family protein 0.003 0.0019 0.235
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0001 0.0002
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0001 0.0003
Echinococcus multilocularis geminin 0.0552 0.0558 0.1904
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0018 0.0065
Plasmodium falciparum thioredoxin reductase 0.0043 0.0033 0.0119
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0115 0.1468
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0082 0.1616
Leishmania major DNA polymerase eta, putative 0.0012 0.0001 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0004 0.0012
Schistosoma mansoni lamin 0.0081 0.0073 0.0248
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0015 0.0004 0.0013
Plasmodium falciparum tubulin gamma chain 0.0012 0 0.0001
Echinococcus granulosus cathepsin l1 0.0061 0.0051 0.0173
Brugia malayi MH2 domain containing protein 0.0122 0.0115 0.0158
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0044 0.016
Echinococcus granulosus tubulin beta 4A class IVa 0.003 0.0019 0.0064
Schistosoma mansoni cpg binding protein 0.0034 0.0024 0.0082
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0091 0.0082 0.0301
Loa Loa (eye worm) glutathione reductase 0.0043 0.0033 0.0418
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0004 0.0014
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0006 0.002
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0014 0.0048
Echinococcus granulosus Tubulin beta 2C chain 0.003 0.0019 0.0064
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0098 0.0089 0.8837
Echinococcus multilocularis cathepsin L 0.0017 0.0006 0.0018
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0027 0.0017 0.0061
Brugia malayi Papain family cysteine protease containing protein 0.0091 0.0082 0.0113
Plasmodium falciparum serine repeat antigen 4 0.0017 0.0006 0.002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0009 0.0031
Brugia malayi hypothetical protein 0.0768 0.0782 0.1076
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0015 0.0004 0.0012
Schistosoma mansoni tubulin subunit alpha 0.0012 0 0.0002
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0004 0.0012
Brugia malayi Intermediate filament tail domain containing protein 0.0081 0.0073 0.01
Giardia lamblia DNA damage repair protein 0.0012 0.0001 0.0002
Brugia malayi Cytochrome P450 family protein 0.0015 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.0004
Echinococcus multilocularis dnaJ subfamily B 0.0464 0.0467 0.1593
Entamoeba histolytica cysteine proteinase 1, putative 0.0047 0.0037 0.4473
Leishmania major beta tubulin 0.003 0.0019 0.0069
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0029 0.0019 0.0062
Loa Loa (eye worm) hypothetical protein 0.0067 0.0058 0.074
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0012 0.0045
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0015 0.0004 0.0569
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0006 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0072
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0 0.0002
Entamoeba histolytica cysteine proteinase, putative 0.0091 0.0082 1
Brugia malayi Telomerase reverse transcriptase 0.7047 0.7265 1
Onchocerca volvulus 0.0082 0.0073 0.0067
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0001 0.0002
Leishmania major cytochrome p450-like protein 0.0024 0.0014 0.0048
Plasmodium vivax tubulin gamma chain, putative 0.0012 0 0.0002
Brugia malayi jmjC domain containing protein 0.0027 0.0017 0.0023
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0044 0.0149
Entamoeba histolytica cysteine protease, putative 0.0047 0.0037 0.4473
Schistosoma mansoni microtubule-associated protein tau 0.2848 0.293 1
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0.0019 0.0064
Brugia malayi cytochrome P450 0.0015 0.0004 0.0005
Entamoeba histolytica cysteine protease, putative 0.0047 0.0037 0.4473
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0054 0.0184
Echinococcus granulosus transient receptor potential ion channel A 0.0093 0.0084 0.0285
Toxoplasma gondii cathepsin CPC2 0.0017 0.0006 0.0021
Loa Loa (eye worm) tubulin beta-1 chain 0.003 0.0019 0.0245
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0028 0.0097
Loa Loa (eye worm) cathepsin B 0.0017 0.0006 0.0072
Toxoplasma gondii cathepsin CPL 0.0091 0.0082 0.0301
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0015 0.0004 0.0569
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0055 0.0187
Schistosoma mansoni intermediate filament proteins 0.0081 0.0073 0.0248
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0017 0.0006 0.0072
Onchocerca volvulus 0.0081 0.0073 0.0067
Trypanosoma brucei unspecified product 0.0027 0.0016 0.0057
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0054 0.0182
Brugia malayi polk-prov protein 0.0012 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.0082 0.1616
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0143 0.0137 0.0465
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0453 0.0457 0.0628
Echinococcus multilocularis tumor protein p63 0.1381 0.1415 0.4827
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.003 0.0019 0.0027
Brugia malayi Cytochrome P450 family protein 0.0024 0.0014 0.0018
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0001 0.0003
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0015 0.0004 0.0012
Schistosoma mansoni tubulin subunit beta 0.003 0.0019 0.0066
Brugia malayi CXXC zinc finger family protein 0.0033 0.0022 0.003
Loa Loa (eye worm) hypothetical protein 0.0139 0.0132 0.1685
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0017 0.0006 0.0021
Plasmodium falciparum glutathione reductase 0.0043 0.0033 0.0119
Schistosoma mansoni transient receptor potential channel 0.0063 0.0054 0.0184
Mycobacterium tuberculosis Probable reductase 0.0098 0.0089 0.8837
Echinococcus multilocularis lysine specific demethylase 5A 0.0102 0.0094 0.0319
Brugia malayi cathepsin Z-like cysteine proteinase 0.0017 0.0006 0.0008
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0073 0.0248
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0028 0.0103
Plasmodium falciparum serine repeat antigen 3 0.0017 0.0006 0.002
Brugia malayi Cathepsin L-like precursor 0.0061 0.0051 0.007
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0054 0.0182
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0018 0.0065
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0073 0.025
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0037 0.0133
Leishmania major hypothetical protein, conserved 0.0029 0.0018 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0105
Echinococcus granulosus tubulin beta 1 chain 0.003 0.0019 0.0064
Schistosoma mansoni cellular tumor antigen P53 0.0202 0.0197 0.0673
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0044 0.0865
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0037 0.0133
Entamoeba histolytica tubulin alpha chain, putative 0.0012 0 0.0059
Trichomonas vaginalis tubulin gamma chain, putative 0.003 0.0019 0.0372
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0017 0.0211
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0004 0.0013
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0015 0.0004 0.0012
Brugia malayi jmjC domain containing protein 0.0104 0.0096 0.0132
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0028 0.5105
Schistosoma mansoni jumonji domain containing protein 0.0142 0.0135 0.0462
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0252 0.4972
Giardia lamblia Sgs1 DNA helicase, putative 0.0023 0.0012 0.0042
Trypanosoma cruzi cruzipain precursor, putative 0.0345 0.0345 0.1266
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0006 0.0072
Brugia malayi Latrophilin receptor protein 2 0.0143 0.0137 0.0188
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.017 0.3365
Plasmodium vivax serine-repeat antigen (SERA) 0.0017 0.0006 0.0021
Leishmania major cathepsin L-like protease 0.0091 0.0082 0.03
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0345 0.0345 0.1266
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0054 0.0185
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0004 0.0067
Giardia lamblia Cathepsin B precursor 0.0017 0.0006 0.0019
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0015 0.0004 0.0569
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0015 0.0004 0.0569
Giardia lamblia Cysteine protease 0.0017 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.0151
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0015 0.0004 0.0569
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0015 0.0004 0.0569
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0109 0.0101 1
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0004 0.0014
Entamoeba histolytica hypothetical protein 0.0017 0.0006 0.0704
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0027 0.0017 0.0061
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0015 0.0004 0.0569
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0044 0.0149
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0028 0.0103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0345 0.0345 0.1266
Plasmodium falciparum serine repeat antigen 9 0.0017 0.0006 0.002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0006 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0051 0.1003
Plasmodium vivax SET domain protein, putative 0.0064 0.0054 0.0199
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0001 0.0003
Brugia malayi cathepsin F-like cysteine proteinase 0.003 0.0019 0.0027
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0055 0.0201
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0017 0.0006 0.0105
Plasmodium falciparum serine repeat antigen 6 0.0017 0.0006 0.002
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0044 0.0161
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0054 0.0182
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0017 0.0006 0.0021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0072
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0091 0.0082 0.0279
Giardia lamblia Cathepsin L-like protease 0.0017 0.0006 0.0019
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0028 0.0103
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0033 0.0112
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0055 0.02
Echinococcus granulosus Tubulin beta 2C chain 0.003 0.0019 0.0064
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0014 0.0172
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0.0019 0.0064
Schistosoma mansoni tubulin subunit beta 0.003 0.0019 0.0066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0006 0.0105
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0022 0.0281
Brugia malayi Calcitonin receptor-like protein seb-1 0.0453 0.0457 0.0628
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0012 0.0042
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0001 0.0003
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0017 0.0006 0.0021
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0017 0.0006 0.0019
Plasmodium falciparum tubulin epsilon chain, putative 0.0012 0 0.0001
Brugia malayi hypothetical protein 0.0029 0.0018 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0037 0.0717
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0028 0.0103
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0012 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.0037 0.4473
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0012 0.1455
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0091 0.0082 0.1616
Echinococcus multilocularis 0.0015 0.0004 0.0012
Schistosoma mansoni tubulin subunit alpha 0.0012 0 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0103
Schistosoma mansoni jumonji domain containing protein 0.0027 0.0017 0.0057
Entamoeba histolytica cysteine protease, putative 0.0047 0.0037 0.4473
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0015 0.0004 0.0569
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0098 0.0089 0.8836
Loa Loa (eye worm) hypothetical protein 0.0061 0.0051 0.0653
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0054 0.0184
Schistosoma mansoni hypothetical protein 0.0143 0.0137 0.0466
Leishmania major telomerase reverse transcriptase, putative 0.2648 0.2723 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0012 0 0.0002
Loa Loa (eye worm) hypothetical protein 0.0032 0.0022 0.028
Mycobacterium tuberculosis Probable oxidoreductase 0.0109 0.0101 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0004 0.0012
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0017 0.0006 0.0021
Leishmania major cathepsin L-like protease 0.0345 0.0345 0.1266
Schistosoma mansoni DNA helicase recq5 0.0023 0.0012 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0016 0.0057
Schistosoma mansoni hypothetical protein 0.0552 0.0558 0.1905
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0037 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0037 0.0717
Schistosoma mansoni alpha tubulin 0.0012 0 0.0002
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0015 0.0004 0.0569
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0015 0.0004 0.0012
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0073 0.0248
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0017 0.0006 0.0021
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0028 0.0103
Echinococcus multilocularis jumonji domain containing protein 0.004 0.003 0.01
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0018 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0082 0.1616
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0004 0.0005
Entamoeba histolytica cysteine protease, putative 0.0047 0.0037 0.4473
Leishmania major trypanothione reductase 0.0043 0.0033 0.0119
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0018 0.0231
Echinococcus granulosus jumonji domain containing 1A 0.0027 0.0017 0.0055
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0037 0.4473
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0103
Plasmodium vivax tubulin epsilon chain, putative 0.0012 0 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0252 0.4972
Loa Loa (eye worm) hypothetical protein 0.0027 0.0017 0.0211
Echinococcus multilocularis cathepsin b 0.0017 0.0006 0.0018
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0015 0.0004 0.0012
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0037 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0091 0.0082 0.1616
Echinococcus granulosus cathepsin l1 0.0091 0.0082 0.0279
Schistosoma mansoni hypothetical protein 0.0029 0.0018 0.0062
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0004 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0082 0.1616
Leishmania major cathepsin L-like protease 0.0091 0.0082 0.03
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0015 0.0004 0.0569
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0.0019 0.0064
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0028 0.2536
Toxoplasma gondii thioredoxin reductase 0.0043 0.0033 0.012
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0017 0.0006 0.0021
Brugia malayi beta-tubulin, identical 0.003 0.0019 0.0026
Schistosoma mansoni transient receptor potential channel 0.0063 0.0054 0.0184
Loa Loa (eye worm) hypothetical protein 0.0091 0.0082 0.1048
Loa Loa (eye worm) hypothetical protein 0.0038 0.0028 0.0351
Toxoplasma gondii beta-tubulin, putative 0.003 0.0019 0.0071
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0017 0.0006 0.0019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0042 0.0143
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0004 0.0012
Trichomonas vaginalis tubulin alpha chain, putative 0.003 0.0019 0.0372
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0006 0.002
Echinococcus multilocularis transient receptor potential ion channel A 0.0093 0.0084 0.0285
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0006 0.0008
Trichomonas vaginalis tubulin epsilon chain, putative 0.003 0.0019 0.0372
Schistosoma mansoni lamin 0.0081 0.0073 0.0248
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0098 0.0089 0.8837
Echinococcus granulosus Tubulin beta 2C chain 0.003 0.0019 0.0064
Leishmania major cathepsin L-like protease 0.0345 0.0345 0.1266
Onchocerca volvulus Alhambra homolog 0.0029 0.0018 0.0012
Loa Loa (eye worm) tubulin beta-4 chain 0.003 0.0019 0.0245
Echinococcus granulosus cysteine protease 0.0047 0.0037 0.0124
Schistosoma mansoni cathepsin F (C01 family) 0.0061 0.0051 0.0175
Schistosoma mansoni hypothetical protein 0.0143 0.0137 0.0466
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0006 0.0105
Trypanosoma cruzi cysteine peptidase, putative 0.003 0.0019 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0006 0.0105
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0091 0.0082 0.1048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.0082 0.1616
Trypanosoma brucei cysteine peptidase C (CPC) 0.0017 0.0006 0.0019
Loa Loa (eye worm) jmjC domain-containing protein 0.0104 0.0096 0.1225
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0017 0.0006 0.002
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0115 0.1468
Loa Loa (eye worm) beta-tubulin 0.003 0.0019 0.0245
Giardia lamblia Cathepsin B precursor 0.0017 0.0006 0.0019
Toxoplasma gondii beta-1 tubulin, putative 0.003 0.0019 0.0071
Leishmania major beta tubulin 0.003 0.0019 0.0069
Plasmodium falciparum alpha tubulin 1 0.0012 0 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0044 0.0865
Brugia malayi jmjC domain containing protein 0.0027 0.0017 0.0023
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0017 0.0006 0.0021
Brugia malayi Cytochrome P450 family protein 0.0024 0.0014 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0082 0.1616
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0047 0.0037 0.0133
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0017 0.0006 0.0008
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0002 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0015 0.0004 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0006 0.0105
Plasmodium falciparum serine repeat antigen 8 0.0017 0.0006 0.002
Leishmania major beta tubulin 0.003 0.0019 0.0069
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0012 0.0039
Entamoeba histolytica cysteine protease, putative 0.0047 0.0037 0.4473
Loa Loa (eye worm) ctsf protein 0.0091 0.0082 0.1048
Onchocerca volvulus 0.0061 0.0051 0.0045
Echinococcus granulosus cathepsin l cysteine peptidase 0.0091 0.0082 0.0279
Loa Loa (eye worm) hypothetical protein 0.0081 0.0073 0.0927
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0012 0.0016
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0012 0.0044
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0018 0.0067
Echinococcus multilocularis microtubule associated protein 2 0.2848 0.293 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0015 0.0004 0.0015
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0015 0.0004 0.0012
Echinococcus multilocularis cpg binding protein 0.0034 0.0024 0.008
Giardia lamblia Cathepsin L-like protease 0.0017 0.0006 0.0019
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0004 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0004 0.0012
Echinococcus granulosus cathepsin b 0.0017 0.0006 0.0018
Leishmania major DNA polymerase eta, putative 0.0039 0.0028 0.0103
Brugia malayi MAP kinase sur-1 0.0054 0.0044 0.0061
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0017 0.0059
Onchocerca volvulus 0.0501 0.0506 0.05
Trypanosoma cruzi cysteine peptidase, putative 0.0345 0.0345 0.1266
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0143 0.0137 0.0465
Plasmodium falciparum serine repeat antigen 5 0.0017 0.0006 0.002
Schistosoma mansoni cytochrome P450 0.0015 0.0004 0.0014
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0015 0.0004 0.0012
Trypanosoma brucei unspecified product 0.0039 0.0028 0.0103
Loa Loa (eye worm) hypothetical protein 0.0139 0.0132 0.1685
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0017 0.0006 0.0105
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0014 0.0172
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0018 0.0065
Echinococcus granulosus survival motor neuron protein 1 0.0768 0.0782 0.2667
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0042 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.0082 0.1616
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0014 0.0048
Loa Loa (eye worm) tubulin alpha-2 chain 0.0012 0 0.0005
Echinococcus granulosus peregrin 0.0029 0.0018 0.0061
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0012 0.0151
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0004 0.0011
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0017 0.0059
Echinococcus multilocularis cysteine protease 0.0091 0.0082 0.0279
Loa Loa (eye worm) cysteine protease 0.0091 0.0082 0.1048
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.0005
Onchocerca volvulus 0.0064 0.0054 0.0049
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0017 0.0211
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0017 0.0006 0.002
Plasmodium vivax unspecified product 0.0047 0.0037 0.0135
Echinococcus multilocularis peregrin 0.0029 0.0018 0.0061
Brugia malayi Tubulin beta-1 chain 0.003 0.0019 0.0026
Entamoeba histolytica cysteine protease, putative 0.0017 0.0006 0.0704
Giardia lamblia Cathepsin L precursor 0.0017 0.0006 0.0019
Echinococcus granulosus lamin dm0 0.0081 0.0073 0.0246
Giardia lamblia Cysteine protease 0.0017 0.0006 0.0019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.0082 0.1616
Giardia lamblia Cathepsin L precursor 0.0017 0.0006 0.0019
Echinococcus granulosus cathepsin L cysteine protease 0.0047 0.0037 0.0124
Plasmodium falciparum serine repeat antigen 7 0.0017 0.0006 0.002
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0015 0.0004 0.0569
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0018 0.0061
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0004 0.0013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0042 0.0142
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0014 0.0048
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0033 0.0119
Echinococcus granulosus phd:f box containing protein 0.0027 0.0017 0.0055
Giardia lamblia Cathepsin B precursor 0.0017 0.0006 0.0019
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0004 0.0011
Trichomonas vaginalis tubulin beta chain, putative 0.003 0.0019 0.0372
Giardia lamblia Beta tubulin 0.003 0.0019 0.0069
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0055 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0027 0.0017 0.0055
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0037 0.005
Brugia malayi cathepsin L-like cysteine proteinase 0.0017 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0039 0.0028 0.0362
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0016 0.0057
Loa Loa (eye worm) hypothetical protein 0.006 0.0051 0.0646
Echinococcus multilocularis cathepsin L 0.0047 0.0037 0.0124
Echinococcus granulosus JmjC domain containing protein 4 0.0027 0.0017 0.0055
Leishmania major beta tubulin 0.003 0.0019 0.0069
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0006 0.002
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0023 0.0012 0.0039
Schistosoma mansoni hypothetical protein 0.0143 0.0137 0.0466
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.0033 0.2985
Schistosoma mansoni phosphatidylserine receptor 0.0027 0.0017 0.0057
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0044 0.0161
Leishmania major beta tubulin 0.003 0.0019 0.0069
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0028 0.0103
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0004 0.0012
Trichomonas vaginalis tubulin, putative 0.003 0.0019 0.0372
Schistosoma mansoni cathepsin S (C01 family) 0.0017 0.0006 0.002
Giardia lamblia Beta tubulin 0.003 0.0019 0.0069
Trypanosoma cruzi cysteine protease, putative 0.0047 0.0037 0.0133

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 10 uM Antiproliferative activity against human K562 cells after 5 days by MTT assay ChEMBL. 19837593

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19837593

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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