Detailed information for compound 110381

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 335.828 | Formula: C17H22ClN3O2
  • H donors: 2 H acceptors: 1 LogP: 1.82 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(N)c(cc1C(=O)NCC12CN3CC(C2)C(C1)C3)Cl
  • InChi: 1S/C17H22ClN3O2/c1-23-15-3-14(19)13(18)2-12(15)16(22)20-8-17-4-10-6-21(9-17)7-11(10)5-17/h2-3,10-11H,4-9,19H2,1H3,(H,20,22)
  • InChiKey: UVHMYOBKZSQXOO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin 4 (5-HT4) receptor Starlite/ChEMBL No references
Homo sapiens dopamine receptor D2 Starlite/ChEMBL No references
Rattus norvegicus Serotonin 3 (5-HT3) receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Get druggable targets OG5_133042 All targets in OG5_133042
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 473 aa 27.5 %
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) Serotonin 3 (5-HT3) receptor   483 aa 503 aa 22.3 %
Brugia malayi acetylcholine receptor alpha subunit precursor, putative Serotonin 3 (5-HT3) receptor   483 aa 463 aa 26.8 %
Loa Loa (eye worm) hypothetical protein Serotonin 4 (5-HT4) receptor   406 aa 384 aa 22.4 %
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-9-II precursor, putative Serotonin 3 (5-HT3) receptor   483 aa 457 aa 24.7 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein Serotonin 3 (5-HT3) receptor   483 aa 388 aa 21.9 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 4 (5-HT4) receptor   406 aa 348 aa 30.7 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Serotonin 3 (5-HT3) receptor   483 aa 482 aa 25.1 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Serotonin 4 (5-HT4) receptor   406 aa 407 aa 25.1 %
Echinococcus granulosus thyrotropin releasing hormone receptor Serotonin 4 (5-HT4) receptor   406 aa 351 aa 22.2 %
Onchocerca volvulus Phospholipase d-related homolog Serotonin 4 (5-HT4) receptor   406 aa 389 aa 19.3 %
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative Serotonin 3 (5-HT3) receptor   483 aa 514 aa 23.2 %
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 457 aa 26.7 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 4 (5-HT4) receptor   406 aa 445 aa 22.2 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Serotonin 4 (5-HT4) receptor   406 aa 352 aa 21.3 %
Onchocerca volvulus Putative zinc finger protein Serotonin 3 (5-HT3) receptor   483 aa 489 aa 25.8 %
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative Serotonin 3 (5-HT3) receptor   483 aa 478 aa 25.1 %
Onchocerca volvulus Large subunit GTPase 1 homolog Serotonin 3 (5-HT3) receptor   483 aa 394 aa 19.3 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 4 (5-HT4) receptor   406 aa 384 aa 33.3 %
Schistosoma mansoni biogenic amine (5HT) receptor Serotonin 4 (5-HT4) receptor   406 aa 385 aa 31.7 %
Echinococcus granulosus orexin receptor type 2 Serotonin 4 (5-HT4) receptor   406 aa 445 aa 22.2 %
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 470 aa 26.8 %
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit Serotonin 3 (5-HT3) receptor   483 aa 445 aa 25.6 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Serotonin 3 (5-HT3) receptor   483 aa 465 aa 27.3 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   406 aa 386 aa 22.8 %
Drosophila melanogaster nicotinic Acetylcholine Receptor alpha2 Serotonin 3 (5-HT3) receptor   483 aa 541 aa 25.5 %
Brugia malayi Cation transporter family protein Serotonin 3 (5-HT3) receptor   483 aa 507 aa 28.2 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Serotonin 3 (5-HT3) receptor   483 aa 465 aa 27.3 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 452 aa 29.2 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   406 aa 387 aa 30.5 %
Echinococcus multilocularis allatostatin A receptor Serotonin 4 (5-HT4) receptor   406 aa 331 aa 26.0 %
Loa Loa (eye worm) acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 484 aa 26.0 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   406 aa 336 aa 24.1 %
Echinococcus granulosus allatostatin A receptor Serotonin 4 (5-HT4) receptor   406 aa 345 aa 25.2 %
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 482 aa 23.9 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   406 aa 346 aa 23.1 %
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-3 precursor, putative Serotonin 3 (5-HT3) receptor   483 aa 505 aa 21.2 %
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit Serotonin 3 (5-HT3) receptor   483 aa 445 aa 25.4 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type des-2 homolog Serotonin 3 (5-HT3) receptor   483 aa 464 aa 24.8 %
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 Serotonin 3 (5-HT3) receptor   483 aa 387 aa 25.6 %
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 470 aa 27.7 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 489 aa 31.3 %
Echinococcus multilocularis nAChR subunit Serotonin 3 (5-HT3) receptor   483 aa 495 aa 24.2 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 461 aa 24.3 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 477 aa 26.6 %
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor Serotonin 3 (5-HT3) receptor   483 aa 457 aa 26.9 %
Onchocerca volvulus 39S ribosomal protein L13, mitochondrial homolog Serotonin 3 (5-HT3) receptor   483 aa 490 aa 31.0 %
Brugia malayi Serotonin/octopamine receptor family protein 7 Serotonin 4 (5-HT4) receptor   406 aa 390 aa 27.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0186 0.0676
Trypanosoma brucei short-chain dehydrogenase, putative 0.0014 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.004
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0163 0.0701 0.3567
Leishmania major protein kinase, putative 0.0035 0.0104 0.0367
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.0701 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.004
Loa Loa (eye worm) cytochrome P450 family protein 0.0142 0.0604 0.2946
Mycobacterium leprae Possible regulatory protein 0.0035 0.0101 0.8312
Brugia malayi dehydrogenases, short chain protein 9 0.0014 0.0005 0.0007
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0039 0.0121 0.248
Echinococcus granulosus caspase 0.0431 0.1957 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0039 0.0121 0.248
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0163 0.0701 0.2597
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0017 0.0019 0.0294
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.004
Echinococcus multilocularis aryl hydrocarbon receptor 0.0035 0.0101 0.0493
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0035 0.0101 0.1383
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0201 0.0982
Loa Loa (eye worm) hypothetical protein 0.0152 0.0649 0.3164
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0114 0.0472 0.2394
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0025
Loa Loa (eye worm) oxidoreductase 0.0014 0.0005 0.0025
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0015 0.0008 0.0016
Giardia lamblia Telomerase catalytic subunit 0.0587 0.2686 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0015 0.0008 0.0016
Loa Loa (eye worm) intermediate filament protein 0.0025 0.0054 0.0263
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0025
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0015 0.0008 0.0011
Trypanosoma cruzi metacaspase, putative 0.0163 0.0701 0.2597
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0015 0.0008 0.0011
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0136 0.0576 0.2129
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0015 0.0008 0.0011
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0005 0.0007
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0039 0.0121 0.248
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0005 0.0007
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0186 0.0676
Echinococcus multilocularis caspase 3 0.0268 0.1193 0.6087
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0035 0.0104 0.0367
Toxoplasma gondii RNA-directed DNA polymerase 0.0587 0.2686 1
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0039 0.0121 0.248
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0186 0.0688
Echinococcus multilocularis caspase 8 0.0163 0.0701 0.3567
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0078 0.0301 0.1105
Echinococcus multilocularis caspase 2 0.0315 0.1412 0.7212
Trichomonas vaginalis guanylate cyclase, putative 0.0035 0.0101 0.1383
Trypanosoma brucei cytochrome P450, putative 0.0056 0.0201 0.0745
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0163 0.0701 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.004
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0113 0.0468 0.1726
Onchocerca volvulus 0.0025 0.0054 0.0049
Echinococcus granulosus glycine receptor subunit beta 0.0015 0.0008 0.0016
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0035 0.0104 0.0367
Schistosoma mansoni nAChR subunit 0.0015 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0046 0.0151 0.0736
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0039 0.0121 0.248
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0101 0.1383
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0015 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0451 0.2051 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0039 0.0121 0.0432
Brugia malayi cytochrome P450 0.0039 0.0121 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0101 0.1383
Trypanosoma brucei Metacaspase-4 0.0163 0.0701 0.2606
Onchocerca volvulus Putative nachr subunit 0.0015 0.0008 0.0003
Leishmania major DNA polymerase kappa, putative 0.0017 0.0019 0.0051
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0015 0.0008 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0057 0.0208
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0186 0.0676
Plasmodium vivax telomerase reverse transcriptase, putative 0.0587 0.2686 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0071 0.0271 0.0992
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0005 0.0007
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0136 0.0576 0.2925
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0017 0.0019 0.0051
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0039 0.0121 0.248
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.004
Echinococcus granulosus histone acetyltransferase KAT2B 0.0078 0.0301 0.1518
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0163 0.0701 1
Schistosoma mansoni caspase-3 (C14 family) 0.0431 0.1957 1
Trypanosoma brucei protein kinase, putative 0.0053 0.0186 0.0688
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0186 0.0908
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0035 0.0101 0.0493
Loa Loa (eye worm) hypothetical protein 0.0025 0.0054 0.0263
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0113 0.0468 0.2371
Brugia malayi PAS domain containing protein 0.0135 0.0568 0.0783
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0039 0.0121 0.248
Schistosoma mansoni cellular tumor antigen P53 0.0046 0.0151 0.0748
Trypanosoma brucei metacaspase MCA3 0.0163 0.0701 0.2606
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0015 0.0008 0.0011
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0136 0.0576 0.2129
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0035 0.0101 0.1383
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0096 0.0351
Plasmodium vivax hypothetical protein, conserved 0.0163 0.0701 0.2597
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0025
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0136 0.0576 0.2925
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0014 0.0005 0.0013
Trypanosoma cruzi DNA polymerase kappa, putative 0.0034 0.0096 0.0339
Loa Loa (eye worm) oxidoreductase 0.0014 0.0005 0.0025
Plasmodium falciparum telomerase reverse transcriptase 0.0587 0.2686 1
Schistosoma mansoni intermediate filament proteins 0.0025 0.0054 0.025
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0163 0.0701 1
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.0701 1
Brugia malayi Dehydrogenases, short chain protein 30 0.0014 0.0005 0.0007
Brugia malayi intermediate filament protein 0.0025 0.0054 0.0074
Schistosoma mansoni caspase-7 (C14 family) 0.0315 0.1412 0.7212
Echinococcus multilocularis ubiquitin specific protease 41 0.0136 0.0576 0.2925
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0039 0.0121 0.248
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0576 0.8201
Schistosoma mansoni caspase-7 (C14 family) 0.0431 0.1957 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0186 0.0928
Trypanosoma cruzi metacaspase 5, putative 0.0163 0.0701 0.2597
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0035 0.0104 0.0367
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0039 0.0121 0.0445
Echinococcus granulosus apoptotic protease activating factor 1 0.0152 0.0649 0.3299
Brugia malayi oxidoreductase 0.0014 0.0005 0.0007
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0039 0.0121 0.248
Schistosoma mansoni lamin 0.0025 0.0054 0.025
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.004
Entamoeba histolytica acetyltransferase, GNAT family 0.0071 0.0271 0.4658
Trypanosoma brucei DNA polymerase IV, putative 0.0028 0.007 0.0257
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0005 0.0007
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0114 0.0472 0.2394
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0008 0.0011
Trichomonas vaginalis guanylate cyclase, putative 0.0035 0.0101 0.1383
Schistosoma mansoni lamin 0.0025 0.0054 0.025
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0039 0.0121 0.0432
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0114 0.0472 0.1742
Schistosoma mansoni nAChR subunit 0.0015 0.0008 0.0016
Schistosoma mansoni nAChR subunit 0.0015 0.0008 0.0016
Trypanosoma brucei metacaspase 5, putative 0.0163 0.0701 0.2606
Loa Loa (eye worm) hypothetical protein 0.0035 0.0101 0.0494
Toxoplasma gondii cytochrome p450 superfamily protein 0.0039 0.0121 0.0432
Brugia malayi hypoxia-induced factor 1 0.0416 0.1887 0.2603
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0039 0.0121 0.248
Brugia malayi Cytochrome P450 family protein 0.0056 0.0201 0.0278
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0056 0.0201 0.4204
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0005 0.0007
Mycobacterium ulcerans putative regulatory protein 0.01 0.0404 0.8537
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0014 0.0005 0.0013
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0015 0.0008 0.0011
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0039 0.0121 0.248
Echinococcus granulosus caspase 3 0.0268 0.1193 0.6087
Brugia malayi excitatory GABA receptor EXP-1A 0.0015 0.0008 0.0011
Schistosoma mansoni cytochrome P450 0.0039 0.0121 0.0594
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.004
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0163 0.0701 0.0967
Trypanosoma brucei short-chain dehydrogenase, putative 0.0014 0.0005 0.0013
Brugia malayi Cytochrome P450 family protein 0.0142 0.0604 0.0833
Trypanosoma brucei telomerase reverse transcriptase 0.0587 0.2686 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0015 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.004
Brugia malayi Intermediate filament tail domain containing protein 0.0025 0.0054 0.0074
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0136 0.0576 0.2925
Brugia malayi Telomerase reverse transcriptase 0.1562 0.7252 1
Schistosoma mansoni hypothetical protein 0.0152 0.0649 0.3299
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0039 0.0121 0.248
Echinococcus granulosus cytochrome P450 2K1 0.0039 0.0121 0.0594
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0025
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0039 0.0121 0.0432
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0005 0.0007
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0035 0.0101 0.1383
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0015 0.0008 0.004
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0186 0.0676
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0186 0.0676
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0096 0.0351
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0101 0.1383
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0015 0.0008 0.004
Brugia malayi polk-prov protein 0.0026 0.0057 0.0079
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0014 0.0005 0.5
Trichomonas vaginalis bromodomain-containing protein, putative 0.0078 0.0301 0.4255
Brugia malayi Cytochrome P450 family protein 0.0056 0.0201 0.0278
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0034 0.0096 0.1304
Leishmania major cytochrome p450-like protein 0.0056 0.0201 0.0732
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0005 0.0007
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0008 0.0011
Brugia malayi MAP kinase sur-1 0.0053 0.0186 0.0257
Onchocerca volvulus 0.0046 0.0151 0.0146
Echinococcus multilocularis nAChR subunit 0.0015 0.0008 0.0016
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0136 0.0576 0.8201
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0015 0.0008 0.0016
Trypanosoma cruzi DNA polymerase kappa, putative 0.0034 0.0096 0.0339
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0005 0.0007
Schistosoma mansoni hypothetical protein 0.0039 0.0121 0.0594
Mycobacterium leprae Conserved hypothetical protein 0.0039 0.0121 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0078 0.0301 0.1105
Echinococcus granulosus single minded 2 0.01 0.0404 0.2043
Echinococcus multilocularis lamin 0.0025 0.0054 0.025
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0005 0.0007
Leishmania major cytochrome p450-like protein 0.0039 0.0121 0.0432
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0039 0.0121 0.248
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0163 0.0701 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0113 0.0468 0.9905
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0034 0.0096 0.0339
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0039 0.0121 0.248
Brugia malayi Cation transporter family protein 0.0015 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0025
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0114 0.0472 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0014 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.0163 0.0701 0.3419
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0431 0.1957 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0264 0.1174 0.5991
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0163 0.0701 1
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0039 0.0121 0.248
Echinococcus granulosus glycine receptor subunit alpha 1 0.0015 0.0008 0.0016
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0014 0.0005 0.0025
Echinococcus multilocularis lamin dm0 0.0025 0.0054 0.025
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.0008 0.0011
Schistosoma mansoni aldehyde dehydrogenase 0.0113 0.0468 0.2371
Onchocerca volvulus 0.01 0.0404 0.0399
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0035 0.0101 0.0494
Brugia malayi hypothetical protein 0.0152 0.0649 0.0895
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0136 0.0576 0.2925
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0035 0.0101 0.5
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0015 0.0008 0.0016
Echinococcus granulosus lamin 0.0025 0.0054 0.025
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0035 0.0101 0.0359
Plasmodium falciparum metacaspase 1 0.0163 0.0701 0.2597
Onchocerca volvulus 0.0015 0.0008 0.0003
Loa Loa (eye worm) acetyltransferase 0.0264 0.1174 0.5725
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0039 0.0121 0.0432
Echinococcus multilocularis dna polymerase kappa 0.0034 0.0096 0.0465
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0019 0.0064
Trypanosoma brucei short-chain dehydrogenase, putative 0.0014 0.0005 0.0013
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0039 0.0121 0.248
Mycobacterium ulcerans DNA polymerase IV 0.0034 0.0096 0.1943
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0015 0.0008 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0039 0.0121 0.248
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0136 0.0576 0.8201
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0163 0.0701 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0096 0.0351
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0039 0.0121 0.248
Echinococcus granulosus caspase 8 0.0163 0.0701 0.3567
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.0701 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0136 0.0576 0.2129
Trypanosoma cruzi metacaspase, putative 0.0163 0.0701 0.2597
Leishmania major metacaspase, putative 0.0163 0.0701 0.2597
Schistosoma mansoni aryl hydrocarbon receptor 0.0135 0.0568 0.2882
Echinococcus multilocularis apoptotic protease activating factor 1 0.0152 0.0649 0.3299
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0039 0.0121 0.248
Trypanosoma brucei metacaspase MCA2 0.0163 0.0701 0.2606
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0096 0.0351
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0039 0.0121 0.248
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0096 0.0351
Loa Loa (eye worm) hypothetical protein 0.0024 0.0052 0.0253
Plasmodium vivax metacaspase 1, putative 0.0163 0.0701 0.2597
Trichomonas vaginalis DNA polymerase eta, putative 0.0034 0.0096 0.1304
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0025 0.0054 0.0263
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.004
Onchocerca volvulus 0.0035 0.0101 0.0096
Loa Loa (eye worm) CYP4Cod1 0.0056 0.0201 0.0982
Trypanosoma cruzi metacaspase, putative 0.0163 0.0701 0.2597
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0015 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0018 0.0089
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0114 0.0472 0.2394
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0114 0.0472 0.0651
Trypanosoma brucei metacaspase 0.0163 0.0701 0.2606
Brugia malayi Retinol dehydrogenase 12 0.0014 0.0005 0.0007
Loa Loa (eye worm) oxidoreductase 0.0014 0.0005 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0039 0.0121 0.248
Trichomonas vaginalis adenylate cyclase, putative 0.0035 0.0101 0.1383
Loa Loa (eye worm) oxidoreductase 0.0014 0.0005 0.0025
Brugia malayi Cation transporter family protein 0.0015 0.0008 0.0011
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0039 0.0121 0.248
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0014 0.0005 0.0013
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0015 0.0008 0.0016
Echinococcus granulosus dna polymerase kappa 0.0034 0.0096 0.0465
Trypanosoma cruzi DNA polymerase kappa, putative 0.0034 0.0096 0.0339
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0039 0.0121 0.248
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0015 0.0008 0.004
Echinococcus granulosus histone acetyltransferase KAT2B 0.0257 0.114 0.5813
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0025
Echinococcus granulosus aryl hydrocarbon receptor 0.0035 0.0101 0.0493
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.0008 0.0011
Schistosoma mansoni single-minded 0.0135 0.0568 0.2882
Onchocerca volvulus 0.0015 0.0008 0.0003
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.004
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0015 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0025
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0186 0.0676
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.004
Onchocerca volvulus 0.0015 0.0008 0.0003
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0005 0.0007
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0015 0.0008 0.0016
Leishmania major telomerase reverse transcriptase, putative 0.0587 0.2686 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0005 0.0007
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0039 0.0121 0.248
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0186 0.2602
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0096 0.0351
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0015 0.0008 0.0016
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0015 0.0008 0.004
Echinococcus granulosus lamin dm0 0.0025 0.0054 0.025
Schistosoma mansoni nAChR subunit 0.0015 0.0008 0.0016
Onchocerca volvulus 0.0015 0.0008 0.0003
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0015 0.0008 0.0011
Onchocerca volvulus Cell death protein 3 homolog 0.0315 0.1412 0.1408
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.004
Trypanosoma cruzi metacaspase, putative 0.0163 0.0701 0.2597
Mycobacterium ulcerans aldehyde dehydrogenase 0.0113 0.0468 0.9905
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.0701 1
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0035 0.0101 0.0359
Brugia malayi Cell death protein 3 precursor 0.0315 0.1412 0.1948
Mycobacterium ulcerans DNA polymerase IV 0.0034 0.0096 0.1943
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.01 0.0405 0.1974
Loa Loa (eye worm) LGC-31 protein 0.0015 0.0008 0.004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0025
Brugia malayi hypothetical protein 0.0451 0.2051 0.2828
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0136 0.0576 0.214
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0015 0.0008 0.0016
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0014 0.0005 0.0007
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0163 0.0701 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0039 0.0121 0.248
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0015 0.0008 0.0016
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0015 0.0008 0.0016
Echinococcus granulosus ubiquitin specific protease 41 0.0136 0.0576 0.2925
Brugia malayi Dehydrogenases, short chain protein 2 0.0014 0.0005 0.0007
Echinococcus granulosus glycine receptor subunit alpha 1 0.0015 0.0008 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0186 0.2602
Loa Loa (eye worm) ACC-1 protein 0.0015 0.0008 0.004
Trypanosoma cruzi cytochrome P450, putative 0.0056 0.0201 0.0732
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.004
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0008 0.0011
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0039 0.0121 0.248
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0039 0.0121 0.248
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0096 0.0351
Loa Loa (eye worm) oxidoreductase 0.0014 0.0005 0.0025
Leishmania major cytochrome p450-like protein 0.0039 0.0121 0.0432
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0015 0.0008 0.0016
Trypanosoma brucei oxidoreductase-like protein 0.0014 0.0005 0.0013
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0186 0.0928
Schistosoma mansoni aldehyde dehydrogenase 0.0113 0.0468 0.2371
Echinococcus granulosus glycine receptor subunit alpha 1 0.0015 0.0008 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0057 0.0208
Loa Loa (eye worm) cytochrome P450 0.0039 0.0121 0.059
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0186 0.2602
Mycobacterium leprae putative cytochrome p450 0.0039 0.0121 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0078 0.0301 0.1105
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0014 0.0005 0.0013
Onchocerca volvulus 0.0152 0.0649 0.0644
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0113 0.0468 0.2371
Echinococcus multilocularis caspase 0.0431 0.1957 1
Onchocerca volvulus 0.0015 0.0008 0.0003
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0201 0.0982
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0005 0.0007
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0039 0.0121 0.248
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0015 0.0008 0.004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0005 0.0007
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0005 0.0007
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0005 0.0007
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0008 0.0011
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0015 0.0008 0.0016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0113 0.0468 0.9905
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0186 0.0928
Loa Loa (eye worm) hypothetical protein 0.0136 0.0576 0.2809
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0039 0.0121 0.248
Plasmodium falciparum metacaspase-like protein 0.0163 0.0701 0.2597
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0025
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0039 0.0121 0.248
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0163 0.0701 0.2597
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0096 0.0351
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0136 0.0576 0.0794
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0015 0.0008 0.0016
Brugia malayi Cation transporter family protein 0.0015 0.0008 0.0011
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0186 0.0928
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0096 0.0351
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0015 0.0008 0.0016
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0163 0.0701 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0186 0.0928
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0005 0.0007
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0186 0.2602
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0136 0.0576 0.2925
Loa Loa (eye worm) oxidoreductase 0.0014 0.0005 0.0025
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0035 0.0104 0.0367
Echinococcus multilocularis musashi 0.0025 0.0054 0.025
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0005 0.0007
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0114 0.0472 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0039 0.0121 0.248
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0025
Echinococcus granulosus caspase 2 0.0315 0.1412 0.7212
Trypanosoma cruzi cytochrome P450, putative 0.0056 0.0201 0.0732
Trypanosoma brucei unspecified product 0.0028 0.007 0.0257
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0039 0.0121 0.248
Brugia malayi Cytochrome P450 family protein 0.0039 0.0121 0.0167
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0015 0.0008 0.0016
Brugia malayi bHLH-PAS transcription factor 0.01 0.0404 0.0557
Loa Loa (eye worm) oxidoreductase 0.0014 0.0005 0.0025
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0039 0.0121 0.248
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0431 0.1957 1
Echinococcus granulosus nAChR subunit 0.0015 0.0008 0.0016
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0005 0.0007
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0114 0.0472 1
Schistosoma mansoni nAChR subunit 0.0015 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0315 0.1412 0.6887
Echinococcus granulosus intermediate filament protein 0.0025 0.0054 0.025
Toxoplasma gondii aldehyde dehydrogenase 0.0113 0.0468 0.1726
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0039 0.0121 0.248
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.0701 1
Echinococcus granulosus tumor protein p63 0.0311 0.1395 0.7123
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0163 0.0701 0.2597
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0096 0.0351
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0136 0.0576 0.2129
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0587 0.2686 1
Loa Loa (eye worm) dehydrogenase 0.0014 0.0005 0.0025
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0015 0.0008 0.0016
Brugia malayi hypothetical protein 0.0014 0.0005 0.0007
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0035 0.0101 0.0359
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0587 0.2686 1
Giardia lamblia Histone acetyltransferase GCN5 0.0071 0.0271 0.0992
Loa Loa (eye worm) oxidoreductase 0.0014 0.0005 0.0025
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0039 0.0121 0.248
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0039 0.0121 0.248
Loa Loa (eye worm) oxidoreductase 0.0014 0.0005 0.0025
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.0008 0.0011
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0186 0.0676
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0035 0.0101 0.0493
Echinococcus granulosus glycine receptor subunit beta 0.0015 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.004
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0039 0.0121 0.248
Loa Loa (eye worm) hypoxia-induced factor 1 0.0416 0.1887 0.9202
Trypanosoma cruzi metacaspase 5, putative 0.0163 0.0701 0.2597
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0113 0.0468 0.9905
Echinococcus multilocularis 0.0039 0.0121 0.0594
Schistosoma mansoni nAChR subunit 0.0015 0.0008 0.0016
Echinococcus multilocularis glycine receptor subunit beta 0.0015 0.0008 0.0016
Trypanosoma brucei short-chain dehydrogenase, putative 0.0014 0.0005 0.0013
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0008 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.0701 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0039 0.0121 0.248
Onchocerca volvulus 0.0025 0.0054 0.0049
Leishmania major protein kinase, putative 0.0035 0.0104 0.0367
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0163 0.0701 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0264 0.1174 0.5991
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0096 0.0351
Brugia malayi hypothetical protein 0.0014 0.0005 0.0007
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0136 0.0576 0.2925
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0015 0.0008 0.0011
Schistosoma mansoni nAChR subunit 0.0015 0.0008 0.0016
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0035 0.0101 0.1383
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0015 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.028
Brugia malayi dehydrogenases, short chain protein 2 0.0014 0.0005 0.0007
Loa Loa (eye worm) ACC-1 protein 0.0015 0.0008 0.004
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0035 0.0101 0.1383
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0015 0.0008 0.0016
Brugia malayi acetyltransferase, GNAT family protein 0.0264 0.1174 0.1619
Echinococcus multilocularis tumor protein p63 0.0311 0.1395 0.7123
Echinococcus multilocularis transfer RNA-Lys 0.01 0.0404 0.2043
Trypanosoma brucei short-chain dehydrogenase, putative 0.0014 0.0005 0.0013
Echinococcus multilocularis glycine receptor subunit beta 0.0015 0.0008 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0039 0.0121 0.248
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0008 0.0011
Onchocerca volvulus 0.0015 0.0008 0.0003
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.004
Loa Loa (eye worm) dehydrogenase 0.0014 0.0005 0.0025
Giardia lamblia DINP protein human, muc B family 0.0017 0.0019 0.0051
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0014 0.0005 0.0007
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0136 0.0576 1
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0015 0.0008 0.004
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0186 0.0676
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0025
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0078 0.0301 0.4255
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0039 0.0121 0.248

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 217 nM Agonist activity against serotonin 5-HT4 receptor in rat tunica muscularis mucosae assay ChEMBL. No reference
EC50 (functional) = 217 nM Agonist activity against serotonin 5-HT4 receptor in rat tunica muscularis mucosae assay ChEMBL. No reference
IC50 (binding) > 10000 nM Compound was selective withrespect to binding at the Dopamine receptor D2 ChEMBL. No reference
IC50 (binding) > 10000 nM Compound was selective withrespect to binding at the Dopamine receptor D2 ChEMBL. No reference
Inhibition (functional) = 70 % Compound was tested for inhibition of serotonin 5-HT3 receptor mediated bradycardia in Bezold-Jarisch reflex model in mice at 1 mg/kg after intraperitoneal administration ChEMBL. No reference
Inhibition (functional) = 70 % Compound was tested for inhibition of serotonin 5-HT3 receptor mediated bradycardia in Bezold-Jarisch reflex model in mice at 1 mg/kg after intraperitoneal administration ChEMBL. No reference
Ki (binding) = 5 nM Compound was tested for its binding affinity for the 5-hydroxytryptamine 3 receptor ChEMBL. No reference
Ki (binding) = 5 nM Compound was tested for its binding affinity for the 5-hydroxytryptamine 3 receptor ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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