Detailed information for compound 1175852

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 2455.95 | Formula: C116H187N27O29S
  • H donors: 31 H acceptors: 29 LogP: -3.64 Rotable bonds: 101
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)O)Cc1ccc(cc1)O)CC(=O)N)CCCCN)CCCCN)CC(C)C)CC(C)C)C(C)C)CCC(=O)O)CC(C)C)C(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)N)Cc1ccc(cc1)O)CCCCN)CC(=O)N)CC(C)C)CC(=O)N)CC(C)C
  • InChi: 1S/C116H187N27O29S/c1-60(2)48-79(103(158)126-74(24-15-19-43-117)98(153)125-75(25-16-20-44-118)99(154)134-86(56-91(122)147)111(166)133-85(54-68-31-37-71(145)38-32-68)109(164)140-89(116(171)172)55-69-33-39-72(146)40-34-69)131-107(162)83(52-64(9)10)138-114(169)96(66(13)14)142-102(157)78(41-42-94(150)151)129-105(160)82(51-63(7)8)137-113(168)95(65(11)12)141-101(156)77(27-18-22-46-120)128-104(159)80(49-61(3)4)132-110(165)87(57-92(123)148)135-106(161)81(50-62(5)6)136-112(167)90-28-23-47-143(90)115(170)88(58-93(124)149)139-100(155)76(26-17-21-45-119)127-108(163)84(130-97(152)73(121)59-173)53-67-29-35-70(144)36-30-67/h29-40,60-66,73-90,95-96,144-146,173H,15-28,41-59,117-121H2,1-14H3,(H2,122,147)(H2,123,148)(H2,124,149)(H,125,153)(H,126,158)(H,127,163)(H,128,159)(H,129,160)(H,130,152)(H,131,162)(H,132,165)(H,133,166)(H,134,154)(H,135,161)(H,136,167)(H,137,168)(H,138,169)(H,139,155)(H,140,164)(H,141,156)(H,142,157)(H,150,151)(H,171,172)/t73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,95-,96-/m0/s1
  • InChiKey: JXBSAMXKSNESRP-QIWMSLADSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0032 0.0122 0.0333
Trypanosoma cruzi cytochrome P450, putative 0.0051 0.0253 0.565
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0033 0.021
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0181 0.0155
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0081 0.0448 0.0423
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0279 0.1778 0.3861
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1136 0.5841
Mycobacterium tuberculosis Probable oxidoreductase 0.0134 0.0808 0.2426
Schistosoma mansoni L-lactate dehydrogenase 0.0017 0.0026 0.0002
Entamoeba histolytica heat shock transcription factor, putative 0.0109 0.0641 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0038 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.1778 0.9224
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.029 0.0267
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0103 0.0598 0.3034
Schistosoma mansoni apoptosis regulator bax 0.0081 0.0448 0.0425
Echinococcus multilocularis 0.0032 0.0122 0.0096
Mycobacterium tuberculosis Probable reductase 0.0121 0.0718 0.2144
Schistosoma mansoni ran 0.0048 0.0231 0.0207
Trypanosoma brucei protein kinase, putative 0.0057 0.029 0.657
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0048 0.0231 0.0758
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0048 0.0231 0.5095
Schistosoma mansoni inositol monophosphatase 0.0041 0.0181 0.0157
Loa Loa (eye worm) malate dehydrogenase 0.0041 0.0187 0.0354
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0197 0.4259
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0032 0.0122 0.028
Onchocerca volvulus Glucosylceramidase homolog 0.0183 0.1136 0.6497
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0264 0.0724
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0037 0.0011
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0102 0.028
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0048 0.0231 0.5095
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0041 0.0187 0.0161
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0034 0.0008
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0053 0.0263 0.1247
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0173 0.0147
Brugia malayi Pre-SET motif family protein 0.0033 0.0133 0.069
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0034 0.0042
Loa Loa (eye worm) glutathione reductase 0.0053 0.0264 0.0524
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0032 0.0122 0.028
Leishmania major DNA polymerase eta, putative 0.0043 0.0197 0.4259
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0032 0.0122 0.0333
Brugia malayi Inositol-1 0.0041 0.0181 0.0941
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0264 0.0238
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0128 0.0375
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0359 0.0734
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.0429 0.223
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0197 0.4259
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0032 0.0122 0.028
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0381 0.0356
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0032 0.0122 0.2419
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.0429 0.1241
Toxoplasma gondii ABC1 family protein 0.0078 0.0429 0.1496
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0133 0.0109
Brugia malayi glutaminase DH11.1 0.0301 0.1925 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0034 0.0008
Entamoeba histolytica hypothetical protein 0.0019 0.0034 0.013
Trypanosoma brucei unspecified product 0.0043 0.0197 0.4259
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0197 0.0171
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0429 0.2122
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0034 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.026 0.0237
Echinococcus granulosus cytosolic malate dehydrogenase 0.0041 0.0187 0.0161
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0101 0.0586 0.1729
Loa Loa (eye worm) RNA binding protein 0.0071 0.0385 0.0789
Loa Loa (eye worm) hypothetical protein 0.0056 0.0283 0.0566
Schistosoma mansoni DNA polymerase eta 0.0043 0.0197 0.0173
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0128 0.0223
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0349 0.0326
Plasmodium falciparum thioredoxin reductase 0.0018 0.0033 0.0023
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0213 0.0187
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0034 0.0008
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0197 0.2771
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0041 0.0187 0.0251
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0181 0.3873
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0017 0.0026 0.0059
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0033 0.0032
Brugia malayi jmjC domain containing protein 0.0042 0.0188 0.0975
Trichomonas vaginalis malate dehydrogenase, putative 0.0041 0.0187 0.0847
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0033 0.021
Entamoeba histolytica heat shock transcription factor, putative 0.0109 0.0641 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0033 0.021
Plasmodium vivax SET domain protein, putative 0.0033 0.0133 0.0395
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0041 0.0187 0.0973
Trypanosoma cruzi malate dehydrogenase, putative 0.0017 0.0026 0.0059
Loa Loa (eye worm) apoptosis regulator protein 0.0081 0.0448 0.093
Trichomonas vaginalis malate dehydrogenase, putative 0.0033 0.0127 0.0532
Loa Loa (eye worm) hypothetical protein 0.0043 0.0197 0.0375
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0385 0.0359
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0109 0.0641 0.3308
Loa Loa (eye worm) glutaminase 2 0.0301 0.1925 0.4185
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0034 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0018
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0429 0.2122
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0032 0.0122 0.0333
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0048 0.0231 0.7681
Brugia malayi beta-lactamase family protein 0.0078 0.0429 0.223
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0034 0.0042
Onchocerca volvulus 0.0033 0.0133 0.0034
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0197 0.0173
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.0429 0.0404
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0197 0.4259
Brugia malayi PXA domain containing protein 0.0019 0.0034 0.0179
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0696 0.4564 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0181 0.2516
Schistosoma mansoni ap endonuclease 0.0021 0.0051 0.0027
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0102 0.1918
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0128 0.0375
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0038 0.0014
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0041 0.0187 0.4025
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.029 1
Entamoeba histolytica Ran family GTPase 0.0048 0.0231 0.3323
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0197 0.4259
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0034 0.0008
Mycobacterium leprae conserved hypothetical protein 0.0078 0.0429 0.1183
Trypanosoma cruzi cytochrome P450, putative 0.0051 0.0253 0.565
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0033 0.021
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0032 0.0122 0.028
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.042 0.2719 1
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0034 0.0042
Trypanosoma cruzi importin beta-1 subunit, putative 0.0053 0.0263 0.5901
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0017 0.0026 0.0059
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0349 0.0326
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0032 0.0122 0.028
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0034 0.001
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.0429 0.1241
Entamoeba histolytica hypothetical protein 0.0019 0.0034 0.013
Schistosoma mansoni zinc finger protein 0.0026 0.0082 0.0058
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0349 0.099
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0038 0.0014
Brugia malayi mbt repeat family protein 0.0103 0.0598 0.3107
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0033 0.021
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0181 0.0814
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0197 0.4259
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0429 0.2122
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.0429 0.1241
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0197 0.4259
Leishmania major importin beta-1 subunit, putative 0.0053 0.0263 0.5901
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0034 0.0008
Echinococcus granulosus dna polymerase kappa 0.0043 0.0197 0.0171
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0038 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.1778 0.9224
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0197 0.4259
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0134 0.0808 0.2426
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0033 0.021
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.0429 0.1241
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0032 0.0122 0.0333
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0053 0.0263 0.1247
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.041 0.2651 0.2632
Trypanosoma brucei trypanothione reductase 0.0053 0.0264 0.5922
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0051 0.0253 0.0821
Mycobacterium tuberculosis Conserved protein 0.0078 0.0429 0.1241
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0034 0.0008
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0032 0.0122 0.028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.0931 0.0909
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0032 0.0122 0.0333
Loa Loa (eye worm) hypothetical protein 0.0052 0.026 0.0515
Trichomonas vaginalis esterase, putative 0.0078 0.0429 0.2122
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1136 0.5841
Brugia malayi cytochrome P450 0.0032 0.0122 0.0634
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0197 0.4259
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.1464 0.3169
Loa Loa (eye worm) hypothetical protein 0.0078 0.0429 0.0888
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0051 0.0053
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0032 0.0122 0.028
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0017 0.0026 0.0059
Echinococcus granulosus cytosolic malate dehydrogenase 0.0041 0.0187 0.0161
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0264 0.0238
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0033 0.021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.0931 0.0909
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0041 0.0187 0.0847
Toxoplasma gondii HEAT repeat-containing protein 0.0065 0.0346 0.1186
Trypanosoma brucei cytochrome P450, putative 0.0051 0.0253 0.565
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0033 0.0023
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0032 0.0122 0.0333
Brugia malayi PXA domain containing protein 0.0019 0.0034 0.0179
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0429 0.0406
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0108 0.2062
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0048 0.0231 0.0758
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.0931 0.0907
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0385 0.0361
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0349 0.1178
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0034 0.0018
Echinococcus granulosus snurportin 1 0.0696 0.4564 0.4549
Echinococcus multilocularis dna polymerase eta 0.0043 0.0197 0.0171
Trypanosoma cruzi malate dehydrogenase, putative 0.0017 0.0026 0.0059
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0051 0.0128
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0197 0.0611
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0117 0.0694 0.0669
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0032
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.029 0.0582
Schistosoma mansoni ap endonuclease 0.0021 0.0051 0.0027
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0178 0.0152
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0051 0.0264
Mycobacterium ulcerans beta-lactamase 0.0078 0.0429 0.1477
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0048 0.0231 0.5095
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0018
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0034 0.0179
Echinococcus granulosus polycomb protein SCMH1 0.0103 0.0598 0.0573
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0034 0.0179
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0181 0.3873
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1136 0.5841
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1136 0.5841
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0385 0.0361
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0197 0.4259
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0032 0.0122 0.0333
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0033 0.021
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0429 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0107 0.0623 0.0598
Loa Loa (eye worm) hypothetical protein 0.0079 0.0438 0.0907
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0128 0.0375
Schistosoma mansoni hypothetical protein 0.0023 0.0064 0.004
Loa Loa (eye worm) hypothetical protein 0.0078 0.0429 0.0888
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0159 0.0976 0.0954
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0032 0.0122 0.028
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0034 0.0008
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0133 0.0395
Loa Loa (eye worm) MBCTL1 0.0117 0.0694 0.147
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0051 0.0068
Leishmania major cytochrome p450-like protein 0.0032 0.0122 0.2419
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0034 0.0042
Brugia malayi PHD-finger family protein 0.0032 0.0122 0.0631
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0108 0.2062
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0034 0.001
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.029 0.139
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0192 0.62
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0197 0.4259
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0034 0.0042
Trichomonas vaginalis malate dehydrogenase, putative 0.0041 0.0187 0.0847
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0117 0.0694 0.0669
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0253 0.05
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.1778 0.9224
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0236 0.0777
Brugia malayi RNA, U transporter 1 0.0185 0.1149 0.597
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.029 0.0265
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0213 0.0187
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0033 0.021
Brugia malayi Cytochrome P450 family protein 0.0051 0.0253 0.1315
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0349 0.1178
Echinococcus multilocularis geminin 0.1509 1 1
Loa Loa (eye worm) glutaminase 0.0301 0.1925 0.4185
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0159 0.0976 0.0952
Onchocerca volvulus 0.0078 0.0429 0.1946
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0032 0.0122 0.028
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0102 0.0076
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0037 0.0013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.0931 0.0907
Schistosoma mansoni hypothetical protein 0.063 0.4124 0.4109
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0197 0.4259
Brugia malayi PHD-finger family protein 0.0033 0.0128 0.0663
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0032 0.0122 0.028
Trichomonas vaginalis malate dehydrogenase, putative 0.0041 0.0187 0.0847
Loa Loa (eye worm) hypothetical protein 0.0109 0.0641 0.1354
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0349 0.0323
Toxoplasma gondii cytochrome p450 superfamily protein 0.0032 0.0122 0.0355
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0125 0.0098
Loa Loa (eye worm) cytochrome P450 0.0032 0.0122 0.0211
Trichomonas vaginalis malate dehydrogenase, putative 0.0041 0.0187 0.0847
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0197 0.0173
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0051 0.0057
Schistosoma mansoni hypothetical protein 0.0081 0.0448 0.0425
Schistosoma mansoni hypothetical protein 0.0081 0.0448 0.0425
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0181 0.0574
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0385 0.1997
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.1202 0.6188
Brugia malayi hypothetical protein 0.0019 0.0034 0.0179
Echinococcus granulosus importin subunit beta 1 0.0065 0.0346 0.032
Loa Loa (eye worm) hypothetical protein 0.0078 0.0429 0.0888
Schistosoma mansoni importin beta-1 0.0065 0.0346 0.0322
Brugia malayi hypothetical protein 0.0019 0.0034 0.0179
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0038 0.0014
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0033 0.0023
Loa Loa (eye worm) inositol-1 0.0041 0.0181 0.0341
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0107 0.0623 0.0598
Brugia malayi Thioredoxin reductase 0.0053 0.0264 0.1372
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0081 0.0448 0.0423
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0102 0.1918
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0034 0.0179
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0349 0.1178
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.029 0.0265
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0264 0.0883
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0033 0.0023
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.0429 0.0404
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0032 0.0122 0.0333
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0032 0.0122 0.2419
Leishmania major DNA polymerase kappa, putative 0.0043 0.0197 0.4259
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0018
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0102 0.0397
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0236 0.0777
Schistosoma mansoni sex comb on midleg homolog 0.0103 0.0598 0.0576
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0033 0.021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0033 0.021
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0197 0.4259
Brugia malayi RNA binding protein 0.0071 0.0385 0.1997
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0032 0.0122 0.0333
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.026 0.0237
Trypanosoma brucei malate dehydrogenase-related 0.0017 0.0026 0.0059
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.1778 0.9224
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0051 0.0395
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0033 0.0032
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.0718 0.2144
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0197 0.4259
Trypanosoma brucei unspecified product 0.003 0.0108 0.2062
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.0429 0.1241
Trichomonas vaginalis ran, putative 0.0048 0.0231 0.1075
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0051 0.0704
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0429 1
Echinococcus granulosus zinc finger protein 0.0026 0.0082 0.0055
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0034 0.001
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0181 0.0574
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0032 0.0122 0.028
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0032 0.0122 0.2419
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0032 0.0122 0.0333
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.029 0.098
Brugia malayi glutathione reductase 0.0053 0.0264 0.1372
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0153 0.0931 0.4835
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0032 0.0122 0.0333
Loa Loa (eye worm) hypothetical protein 0.0078 0.0429 0.0888
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0032 0.0122 0.0333
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0041 0.0187 0.0847
Brugia malayi beta-lactamase 0.0078 0.0429 0.223
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.042 0.2719 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0381 0.0356
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0128 0.0101
Loa Loa (eye worm) hypothetical protein 0.0065 0.0346 0.0704
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0197 0.0897
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.029 0.657
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0034 0.001
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0264 0.5922
Schistosoma mansoni myelin transcription factor 1 myt1 0.0117 0.0694 0.0671
Schistosoma mansoni malate dehydrogenase 0.0017 0.0026 0.0002
Entamoeba histolytica heat shock transcription factor, putative 0.0109 0.0641 1
Brugia malayi beta-lactamase family protein 0.0078 0.0429 0.223
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0349 0.0323
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0108 0.2062
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0032 0.0122 0.028
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0051 0.0068
Mycobacterium ulcerans malate dehydrogenase 0.0041 0.0187 0.0576
Plasmodium falciparum glutathione reductase 0.0018 0.0033 0.0023
Trichomonas vaginalis malate dehydrogenase, putative 0.0041 0.0187 0.0847
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0034 0.0042
Brugia malayi lactate dehydrogenase. 0.0017 0.0026 0.0137
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0197 0.0611
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0429 0.2122
Brugia malayi TAR-binding protein 0.0071 0.0385 0.1997
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0178 0.0152
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0032 0.0122 0.028
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0102 0.2685
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.042 0.2719 1
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0041 0.0187 0.0847
Giardia lamblia Malate dehydrogenase 0.0041 0.0187 0.5999
Leishmania major cytochrome p450-like protein 0.0051 0.0253 0.565
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0197 0.4259
Echinococcus granulosus neuropeptide receptor A26 0.0517 0.3364 0.3346
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0197 0.0171
Brugia malayi MH2 domain containing protein 0.0134 0.0804 0.4178
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.0804 0.1715
Brugia malayi Bromodomain containing protein 0.0047 0.0222 0.1151
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.042 0.2719 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.0718 0.2144
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.0718 0.2144
Onchocerca volvulus 0.0265 0.1679 1
Schistosoma mansoni jumonji domain containing protein 0.0085 0.0476 0.0453
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0197 0.4259
Leishmania major cytosolic malate dehydrogenase 0.0041 0.0187 0.4025
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0385 0.0361
Plasmodium vivax glutathione reductase, putative 0.0053 0.0264 0.0883
Brugia malayi Bromodomain containing protein 0.0088 0.0496 0.2575
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0048 0.0231 0.0758
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.0718 0.2144
Plasmodium vivax hypothetical protein, conserved 0.0078 0.0429 0.1496
Mycobacterium ulcerans hypothetical protein 0.0078 0.0429 0.1477
Giardia lamblia PHD finger protein 15 0.0033 0.0128 0.3684
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.0429 0.1241
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0385 0.0361
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0034 0.0008
Schistosoma mansoni bromodomain containing protein 0.0075 0.0408 0.0385
Echinococcus granulosus GTP binding nuclear protein Ran 0.0048 0.0231 0.0205
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0033 0.0023
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.029 0.657
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.029 0.0265
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0051 0.009
Echinococcus granulosus SAM and MBT domain containing protein 0.0103 0.0598 0.0573
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0197 0.0513
Echinococcus granulosus dna polymerase eta 0.0043 0.0197 0.0171
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0033 0.0023
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0081 0.0448 0.0423
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0429 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0121 0.0718 0.2295
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0033 0.0023
Plasmodium falciparum thioredoxin reductase 0.0053 0.0264 0.0883
Brugia malayi mbt repeat family protein 0.0103 0.0598 0.3107
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0018
Chlamydia trachomatis malate dehydrogenase 0.0041 0.0187 0.0576
Leishmania major mitochondrial malate dehydrogenase 0.0017 0.0026 0.0059
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.029 0.657
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0034 0.0042
Trichomonas vaginalis malate dehydrogenase, putative 0.0041 0.0187 0.0847
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0128 0.0104
Echinococcus multilocularis microtubule associated protein 2 0.1442 0.9551 0.955
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0134 0.0808 0.2426
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0128 0.0101
Toxoplasma gondii thioredoxin reductase 0.0053 0.0264 0.0883
Schistosoma mansoni flap endonuclease-1 0.0026 0.0083 0.0059
Schistosoma mansoni hypothetical protein 0.0032 0.0122 0.0098
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0078 0.0052
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0051 0.009
Echinococcus granulosus flap endonuclease 1 0.0029 0.0102 0.0076
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0033 0.021
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0429 0.2122
Echinococcus multilocularis neuropeptide s receptor 0.0517 0.3364 0.3346
Mycobacterium ulcerans lipase LipD 0.0078 0.0429 0.1477
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0051 0.0024
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0032 0.0122 0.028
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0034 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.0931 0.0909
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1136 0.5841
Mycobacterium tuberculosis Conserved protein 0.0078 0.0429 0.1241
Loa Loa (eye worm) hypothetical protein 0.0078 0.0429 0.0888
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0197 0.0513
Plasmodium falciparum flap endonuclease 1 0.0029 0.0102 0.028
Trichomonas vaginalis malate dehydrogenase, putative 0.0041 0.0187 0.0847
Leishmania major malate dehydrogenase, putative 0.0017 0.0026 0.0059
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0041 0.0187 0.0484
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0051 0.0128
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0429 0.0406
Brugia malayi Flap endonuclease-1 0.0029 0.0102 0.0529
Trichomonas vaginalis malate dehydrogenase, putative 0.0041 0.0187 0.0847
Schistosoma mansoni hypothetical protein 0.0081 0.0448 0.0425
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0032 0.0122 0.028
Schistosoma mansoni microtubule-associated protein tau 0.1442 0.9551 0.955
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.029 0.139
Leishmania major cytochrome p450-like protein 0.0032 0.0122 0.2419
Entamoeba histolytica hypothetical protein 0.0019 0.0034 0.013
Echinococcus granulosus microtubule associated protein 2 0.1442 0.9551 0.955
Echinococcus multilocularis peregrin 0.0039 0.0171 0.0145
Schistosoma mansoni L-lactate dehydrogenase 0.0017 0.0026 0.0002
Schistosoma mansoni hypothetical protein 0.0033 0.0128 0.0104
Trichomonas vaginalis glutaminase, putative 0.0301 0.1925 1
Leishmania major malate dehydrogenase, putative 0.0017 0.0026 0.0059
Schistosoma mansoni cytochrome P450 0.0032 0.0122 0.0098
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0133 0.0109
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0033 0.0006
Loa Loa (eye worm) acetyltransferase 0.0159 0.0976 0.2093
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0192 0.0616
Echinococcus multilocularis polycomb protein SCMH1 0.0103 0.0598 0.0573
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0197 0.1022
Brugia malayi HSF-type DNA-binding domain containing protein 0.0109 0.0641 0.3329
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0048 0.0231 0.0205
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0181 0.0814
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0188 0.0164
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0032 0.0122 0.0333
Brugia malayi acetyltransferase, GNAT family protein 0.0159 0.0976 0.5069
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0034 0.0008
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0003 0.0018
Echinococcus granulosus endonuclease exonuclease phosphatase 0.041 0.2651 0.2632
Leishmania major hypothetical protein, conserved 0.0078 0.0429 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.0931 0.0907
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0032 0.0122 0.2419
Loa Loa (eye worm) hypothetical protein 0.0103 0.0598 0.126
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.042 0.2719 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0236 0.1102
Giardia lamblia DINP protein human, muc B family 0.0043 0.0197 0.6366
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0034 0.0179
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0188 0.0162
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0038 0.0011
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0133 0.0107
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0067 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0197 0.4259
Leishmania major malate dehydrogenase 0.0017 0.0026 0.0059
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0497 0.323 1
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0102 0.028
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0349 0.8017
Trypanosoma brucei unspecified product 0.003 0.0108 0.2062
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0051 0.0658
Loa Loa (eye worm) hypothetical protein 0.0049 0.024 0.047
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0033 0.0023
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0236 0.021
Echinococcus granulosus histone acetyltransferase KAT2B 0.0152 0.0929 0.0905
Echinococcus multilocularis expressed protein 0.0363 0.2337 0.2316
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0051 0.0658
Loa Loa (eye worm) hypothetical protein 0.0078 0.0429 0.0888
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0034 0.0179
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0033 0.0169
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0102 0.1226
Trichomonas vaginalis malate dehydrogenase, putative 0.0041 0.0187 0.0847
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1136 0.5841
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0181 0.3873
Plasmodium falciparum glutathione reductase 0.0053 0.0264 0.0883
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0034 0.0008
Schistosoma mansoni glutaminase 0.0301 0.1925 0.1906
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0032 0.0122 0.0333
Plasmodium falciparum phd finger protein, putative 0.0033 0.0128 0.0375
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0034 0.0008
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0033 0.021
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.029 0.139
Mycobacterium leprae Probable lipase LipE 0.0078 0.0429 0.1183
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0034 0.001
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0197 0.1022
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0385 0.0789
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0032 0.0122 0.028
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.0429 0.1241
Schistosoma mansoni inositol monophosphatase 0.0041 0.0181 0.0157
Trypanosoma brucei importin beta-1 subunit, putative 0.0065 0.0346 0.7935
Brugia malayi Bromodomain containing protein 0.0039 0.0171 0.0888
Echinococcus granulosus cytochrome P450 2K1 0.0032 0.0122 0.0096
Echinococcus granulosus histone acetyltransferase MYST2 0.0117 0.0694 0.0669
Leishmania major trypanothione reductase 0.0053 0.0264 0.5922
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0253 0.05
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0033 0.021
Brugia malayi Cytochrome P450 family protein 0.0139 0.0839 0.436
Loa Loa (eye worm) hypothetical protein 0.0033 0.0128 0.0223
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0032 0.0122 0.0333
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0033 0.0009
Trypanosoma brucei cytosolic malate dehydrogenase 0.0041 0.0187 0.4025
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1136 0.5841
Schistosoma mansoni hypothetical protein 0.1509 1 1
Echinococcus granulosus peregrin 0.0039 0.0171 0.0145
Trypanosoma brucei glycosomal malate dehydrogenase 0.0017 0.0026 0.0059
Leishmania major glycosomal malate dehydrogenase 0.0017 0.0026 0.0059
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0153 0.0118
Schistosoma mansoni ran 0.0048 0.0231 0.0207
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0051 0.0658
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0188 0.0355
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.0429 0.1477
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.029 0.0265
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.029 0.657
Echinococcus granulosus neuropeptide s receptor 0.0517 0.3364 0.3346
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.042 0.2719 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0103 0.0598 0.0576
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.026 0.0234
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0032 0.0122 0.0333
Echinococcus multilocularis neuropeptide receptor A26 0.0517 0.3364 0.3346
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0032 0.0122 0.028
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0102 0.1918
Entamoeba histolytica hypothetical protein 0.0053 0.0263 0.3854
Brugia malayi Pre-SET motif family protein 0.0233 0.1464 0.7606
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0081 0.0448 0.2328
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0037 0.0013
Brugia malayi jmjC domain containing protein 0.0107 0.0623 0.3236
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0048 0.0231 0.1198
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0034 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0197 0.4259
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0197 0.4259
Schistosoma mansoni malate dehydrogenase 0.0041 0.0187 0.0164
Echinococcus multilocularis zinc finger protein 0.0026 0.0082 0.0055
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0034 0.001
Schistosoma mansoni malate dehydrogenase 0.0017 0.0026 0.0002
Toxoplasma gondii exonuclease III APE 0.0021 0.0051 0.009
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0034 0.0008
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0051 0.0024
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0034 0.0008
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0349 0.1198
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0078 0.0052
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.029 0.139
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0051 0.0658
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0236 0.1102
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0181 0.3873
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0034 0.0008
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0181 0.0553
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0017 0.0026 0.0059
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0192 0.2701
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0197 0.4259
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0236 0.0777
Brugia malayi Cytochrome P450 family protein 0.0051 0.0253 0.1315
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0181 0.0814
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0117 0.0694 0.3602
Loa Loa (eye worm) hypothetical protein 0.0117 0.0694 0.147
Schistosoma mansoni sex comb on midleg homolog 0.0103 0.0598 0.0576
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0081 0.0448 0.0423
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0032 0.0122 0.028
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0033 0.021
Brugia malayi Importin beta-1 subunit 0.0065 0.0346 0.1796
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0032 0.0122 0.0333
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0153 0.0376
Mycobacterium ulcerans glutaminase 0.0301 0.1925 0.7045
Trichomonas vaginalis set domain proteins, putative 0.0265 0.1679 0.8703
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0034 0.001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0196 0.0375
Trichomonas vaginalis malate dehydrogenase, putative 0.0041 0.0187 0.0847
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0033 0.0023
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0041 0.0187 0.0161
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0038 0.0197
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0078 0.0054
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0018
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0153 0.0931 0.1993
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0041 0.0187 0.2617
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.0804 0.1715
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0032 0.0122 0.2419
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0017 0.0026 0.0137
Entamoeba histolytica malate dehydrogenase, putative 0.0041 0.0187 0.2617
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0385 0.0789
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0041 0.0187 0.4025
Schistosoma mansoni hypothetical protein 0.1509 1 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0034 0.0008
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0034 0.0008
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0034 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.1202 0.6188
Trichomonas vaginalis malate dehydrogenase, putative 0.0041 0.0187 0.0847
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0038 0.0025
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.042 0.2719 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0032 0.0122 0.028
Trichomonas vaginalis importin beta-1, putative 0.0053 0.0263 0.1247
Loa Loa (eye worm) hypothetical protein 0.0051 0.0254 0.0502
Onchocerca volvulus 0.0103 0.0598 0.3034
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0197 0.4259
Onchocerca volvulus 0.0078 0.0429 0.1946
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0181 0.0155
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.029 0.657
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0041 0.0187 0.0847
Trypanosoma brucei importin beta-1 subunit, putative 0.0065 0.0346 0.7935
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0034 0.001
Brugia malayi Cytochrome P450 family protein 0.0032 0.0122 0.0634
Loa Loa (eye worm) hypothetical protein 0.0081 0.0448 0.093
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0032 0.0122 0.0333
Echinococcus granulosus tar DNA binding protein 0.0071 0.0385 0.0359
Loa Loa (eye worm) CYP4Cod1 0.0051 0.0253 0.05
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.029 0.657
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.026 0.0234
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0051 0.009
Schistosoma mansoni hypothetical protein 0.0696 0.4564 0.455
Plasmodium falciparum importin beta, putative 0.0065 0.0346 0.1186
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0102 0.0166
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0033 0.021
Echinococcus granulosus expressed protein 0.0363 0.2337 0.2316
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0033 0.021
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0197 0.0171
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0188 0.0164
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0032 0.0122 0.028
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.0429 0.1477
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.029 0.657
Echinococcus multilocularis SAM and MBT domain containing protein 0.0103 0.0598 0.0573
Onchocerca volvulus 0.0078 0.0429 0.1946
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0064 0.0083
Loa Loa (eye worm) cytochrome P450 family protein 0.0139 0.0839 0.1792
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0279 0.1778 0.9235
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.0931 0.0907
Echinococcus multilocularis importin subunit beta 1 0.0065 0.0346 0.032
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0264 0.0524
Loa Loa (eye worm) beta-lactamase 0.0078 0.0429 0.0888
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0197 0.0897
Echinococcus multilocularis histone acetyltransferase MYST2 0.0117 0.0694 0.0669
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0033 0.0006
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.0718 0.2144
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.042 0.2719 1
Echinococcus multilocularis snurportin 1 0.0696 0.4564 0.4549
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0032 0.0122 0.0333
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.0429 0.0888
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0134 0.0808 0.2642
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0034 0.001
Plasmodium vivax importin-beta 2, putative 0.0065 0.0346 0.1186
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.1778 0.9224
Brugia malayi MAP kinase sur-1 0.0057 0.029 0.1508
Leishmania major GTP-binding protein, putative 0.0048 0.0231 0.5095
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0032 0.0122 0.0333
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0385 0.0361
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0048 0.0231 0.045
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0081 0.0448 0.0425
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0037 0.0011
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0197 0.0375
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.1778 0.9224
Loa Loa (eye worm) mbt repeat family protein 0.0103 0.0598 0.126
Schistosoma mansoni malate dehydrogenase 0.0041 0.0187 0.0164
Mycobacterium tuberculosis Conserved protein 0.0078 0.0429 0.1241

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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