Detailed information for compound 1203056

Basic information

Technical information
  • TDR Targets ID: 1203056
  • Name: N-(2-piperidin-1-ylethyl)-2,3-dihydro-1,4-ben zodioxine-7-carboxamide
  • MW: 290.357 | Formula: C16H22N2O3
  • H donors: 1 H acceptors: 1 LogP: 1.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc2c(c1)OCCO2)NCCN1CCCCC1
  • InChi: 1S/C16H22N2O3/c19-16(17-6-9-18-7-2-1-3-8-18)13-4-5-14-15(12-13)21-11-10-20-14/h4-5,12H,1-3,6-11H2,(H,17,19)
  • InChiKey: XKAMAOWLRFYEMR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-(1-piperidyl)ethyl]-2,3-dihydro-1,4-benzodioxine-7-carboxamide
  • N-(2-piperidinoethyl)-2,3-dihydro-1,4-benzodioxine-7-carboxamide
  • MLS000108110
  • SMR000104072
  • Oprea1_529177

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cytochrome P450 family protein 0.0311 0.081 0.081
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0429 0.117 0.8615
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0382 0.1027 0.1027
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0047 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.1189 0.349 0.349
Leishmania major short chain dehydrogenase, putative 0.0047 0.0005 0.0018
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0501 0.139 1
Schistosoma mansoni carbonyl reductase 0.0047 0.0005 0.0003
Schistosoma mansoni aldehyde dehydrogenase 0.0435 0.1188 0.1994
Trypanosoma brucei DNA polymerase kappa, putative 0.009 0.0136 0.0966
Brugia malayi Melibiase family protein 0.0068 0.0069 0.0069
Leishmania major short chain dehydrogenase-like protein 0.0047 0.0005 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0312 0.0813 0.5837
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0173 0.0285
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0632 0.4527
Echinococcus multilocularis glutamate receptor 2 0.0275 0.0699 0.0981
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0465 0.1281 1
Brugia malayi Receptor family ligand binding region containing protein 0.0093 0.0145 0.0145
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0047 0.0005 0.0001
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0311 0.081 0.6313
Leishmania major quinonoid dihydropteridine reductase 0.0047 0.0005 0.0018
Loa Loa (eye worm) cytochrome P450 family protein 0.0972 0.2827 0.2827
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.049 0.1358 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0312 0.0813 0.5837
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0092 0.0142 0.0992
Leishmania major quinonoid dihydropteridine reductase 0.0047 0.0005 0.0018
Echinococcus multilocularis caspase 8 0.0312 0.0813 0.1142
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0311 0.081 0.5949
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0062 0.0049 0.0318
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0314 0.0819 0.5883
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0429 0.117 0.9132
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0501 0.139 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0075 0.0089 0.0621
Echinococcus granulosus apoptotic protease activating factor 1 0.0341 0.0901 0.1266
Trypanosoma cruzi cytochrome P450, putative 0.049 0.1358 0.9767
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0311 0.081 0.5818
Schistosoma mansoni ATP-binding cassette transporter 0.0182 0.0415 0.0693
Leishmania major hypothetical protein, conserved 0.0047 0.0005 0.0018
Echinococcus multilocularis inositol monophosphatase 1 0.0075 0.0089 0.0119
Echinococcus granulosus tumor protein p63 0.1379 0.407 0.5743
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0088 0.013 0.1059
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0501 0.139 1
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0367 0.2613
Loa Loa (eye worm) cytochrome P450 0.0311 0.081 0.081
Brugia malayi dehydrogenases, short chain protein 2 0.0047 0.0005 0.0005
Leishmania major quinonoid dihydropteridine reductase 0.0047 0.0005 0.0018
Mycobacterium tuberculosis Probable oxidoreductase 0.0047 0.0005 0.002
Giardia lamblia Short-chain dehydrogenase, putative 0.0047 0.0005 0.0018
Loa Loa (eye worm) cytochrome P450 family protein 0.049 0.1358 0.1358
Trypanosoma brucei metacaspase MCA3 0.0312 0.0813 0.5845
Schistosoma mansoni steroid dehydrogenase 0.0047 0.0005 0.0003
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0249 0.062 0.087
Leishmania major hypothetical protein, conserved 0.0047 0.0005 0.0018
Echinococcus granulosus caspase 0.0766 0.2199 0.31
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0275 0.0699 0.0981
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0062 0.0049 0.0336
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0047 0.0005 0.002
Echinococcus multilocularis tumor protein p63 0.1379 0.407 0.5743
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.0632 0.0632
Mycobacterium tuberculosis Possible oxidoreductase 0.0047 0.0005 0.002
Trichomonas vaginalis guanylate cyclase, putative 0.0092 0.0142 0.0992
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0047 0.0005 0.002
Loa Loa (eye worm) CYP4Cod1 0.049 0.1358 0.1358
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0168 0.0373 0.0621
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0095 0.0152 0.1064
Brugia malayi hypothetical protein 0.0341 0.0901 0.0901
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0312 0.0813 0.6832
Trypanosoma brucei short-chain dehydrogenase, putative 0.0047 0.0005 0.0018
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0047 0.0005 0.002
Loa Loa (eye worm) oxidoreductase 0.0047 0.0005 0.0005
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0311 0.081 0.5949
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0435 0.1188 0.1672
Mycobacterium ulcerans aldehyde dehydrogenase 0.0435 0.1188 0.8747
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0311 0.081 0.6313
Brugia malayi Cytochrome P450 family protein 0.0972 0.2827 0.2827
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0085 0.012 0.012
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0311 0.081 0.6313
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0275 0.0699 0.0981
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0312 0.0813 0.5837
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0047 0.0005 0.0005
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0173 0.0285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0062 0.0428
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0089 0.0607
Trichomonas vaginalis inositol monophosphatase, putative 0.0075 0.0089 0.0607
Echinococcus multilocularis mitogen activated protein kinase 0.0314 0.0819 0.115
Brugia malayi Cytochrome P450 family protein 0.049 0.1358 0.1358
Schistosoma mansoni steroid dehydrogenase 0.0047 0.0005 0.0003
Loa Loa (eye worm) glutamate receptor 0.0093 0.0145 0.0145
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0311 0.081 0.6313
Mycobacterium tuberculosis Probable oxidoreductase 0.0047 0.0005 0.002
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0047 0.0005 0.0001
Loa Loa (eye worm) RGC/RGC protein kinase 0.0093 0.0145 0.0145
Onchocerca volvulus 0.0341 0.0901 0.4848
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0047 0.0005 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0367 0.2613
Schistosoma mansoni steroid dehydrogenase 0.0047 0.0005 0.0003
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0314 0.0819 0.5883
Loa Loa (eye worm) intermediate filament protein 0.0085 0.012 0.012
Trichomonas vaginalis adenylate cyclase, putative 0.0092 0.0142 0.0992
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.03 0.0776 0.13
Schistosoma mansoni protein kinase 0.0093 0.0145 0.0239
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0632 0.4527
Trichomonas vaginalis CMGC family protein kinase 0.0314 0.0819 0.5875
Schistosoma mansoni aldehyde dehydrogenase 0.0435 0.1188 0.1994
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0275 0.0699 0.0981
Loa Loa (eye worm) oxidoreductase 0.0047 0.0005 0.0005
Mycobacterium tuberculosis Probable oxidoreductase 0.0047 0.0005 0.002
Schistosoma mansoni lipoxygenase 0.0249 0.062 0.1038
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.0065 0.049
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0102 0.0173 0.0237
Echinococcus multilocularis 0.0311 0.081 0.1137
Echinococcus granulosus caspase 2 0.0653 0.1853 0.2612
Brugia malayi PAS domain containing protein 0.0354 0.0943 0.0943
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0311 0.081 0.581
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0501 0.139 0.1957
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0047 0.0005 0.002
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0501 0.139 0.1957
Entamoeba histolytica hypothetical protein 0.0047 0.0005 0.0001
Schistosoma mansoni glutamate receptor AMPA 0.0182 0.0415 0.0693
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0311 0.081 0.5949
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0435 0.1188 0.8546
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0062 0.0049 0.0318
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0093 0.0145 0.0198
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0311 0.081 0.5949
Echinococcus multilocularis glutamate receptor 2 0.0093 0.0145 0.0198
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0062 0.0411
Schistosoma mansoni steroid dehydrogenase 0.0047 0.0005 0.0003
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0019 0.0101
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0311 0.081 0.6313
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0367 0.2613
Loa Loa (eye worm) oxidoreductase 0.0047 0.0005 0.0005
Echinococcus granulosus dna polymerase kappa 0.009 0.0136 0.0186
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0311 0.081 0.5949
Echinococcus granulosus mitogen activated protein kinase 3 0.0314 0.0819 0.115
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0501 0.139 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0465 0.1281 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0062 0.0428
Loa Loa (eye worm) cytochrome P450 family protein 0.049 0.1358 0.1358
Loa Loa (eye worm) oxidoreductase 0.0047 0.0005 0.0005
Leishmania major phosphopantetheinyl transferase-like protein 0.0047 0.0005 0.0019
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0047 0.0005 0.0005
Schistosoma mansoni carbonyl reductase 0.0047 0.0005 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.009 0.0136 0.0966
Schistosoma mansoni short chain dehydrogenase 0.0047 0.0005 0.0003
Toxoplasma gondii aldehyde dehydrogenase 0.0435 0.1188 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0429 0.117 0.117
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0047 0.0005 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0062 0.0428
Mycobacterium leprae putative cytochrome p450 0.0311 0.081 1
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0394 0.281
Leishmania major cytochrome p450-like protein 0.0311 0.081 0.5818
Leishmania major protein kinase, putative 0.0062 0.0049 0.0336
Mycobacterium ulcerans DNA polymerase IV 0.009 0.0136 0.0972
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0312 0.0813 0.6832
Loa Loa (eye worm) hypothetical protein 0.0312 0.0813 0.0813
Schistosoma mansoni retinal dehydrogenase 0.0047 0.0005 0.0003
Onchocerca volvulus 0.0085 0.012 0.0625
Echinococcus granulosus L aminoadipate semialdehyde 0.0168 0.0373 0.052
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0075 0.0089 1
Echinococcus granulosus hypothetical protein 0.0058 0.0039 0.0048
Schistosoma mansoni short chain dehydrogenase 0.0047 0.0005 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0312 0.0813 0.5837
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0311 0.081 0.5949
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0062 0.0428
Echinococcus granulosus lamin dm0 0.0085 0.012 0.0163
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0311 0.081 0.5949
Leishmania major protein kinase, putative 0.0095 0.0152 0.108
Trypanosoma cruzi DNA polymerase kappa, putative 0.009 0.0136 0.0949
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0435 0.1188 0.1672
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0047 0.0005 0.002
Mycobacterium tuberculosis Probable oxidoreductase 0.0047 0.0005 0.002
Brugia malayi Cytochrome P450 family protein 0.049 0.1358 0.1358
Entamoeba histolytica acetyltransferase, GNAT family 0.0081 0.0108 0.0743
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0311 0.081 0.6313
Brugia malayi Protein kinase domain containing protein 0.0062 0.0049 0.0049
Loa Loa (eye worm) oxidoreductase 0.0047 0.0005 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.0314 0.0819 0.5875
Echinococcus multilocularis L aminoadipate semialdehyde 0.0168 0.0373 0.052
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0314 0.0819 0.5883
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0435 0.1188 0.9273
Loa Loa (eye worm) hypoxia-induced factor 1 0.1097 0.3209 0.3209
Loa Loa (eye worm) hypothetical protein 0.0093 0.0145 0.0145
Schistosoma mansoni cytochrome P450 0.0311 0.081 0.1357
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0049 0.0318
Trypanosoma brucei unspecified product 0.0076 0.0092 0.0647
Echinococcus multilocularis lamin dm0 0.0085 0.012 0.0163
Trypanosoma cruzi DNA polymerase kappa, putative 0.009 0.0136 0.0949
Leishmania major short chain dehydrogenase/reductase, putative 0.0047 0.0005 0.0018
Schistosoma mansoni glutamate receptor NMDA 0.0182 0.0415 0.0693
Loa Loa (eye worm) hypothetical protein 0.0093 0.0145 0.0145
Leishmania major metacaspase, putative 0.0312 0.0813 0.5845
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0089 0.0607
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0142 0.0992
Toxoplasma gondii melibiase subfamily protein 0.0102 0.0173 0.1417
Trypanosoma brucei DNA polymerase kappa, putative 0.009 0.0136 0.0966
Trypanosoma brucei DNA polymerase kappa, putative 0.009 0.0136 0.0966
Loa Loa (eye worm) hypothetical protein 0.0047 0.0005 0.0005
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0501 0.139 1
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0092 0.0142 0.0992
Trichomonas vaginalis DNA polymerase eta, putative 0.009 0.0136 0.0949
Loa Loa (eye worm) hypothetical protein 0.0736 0.2107 0.2107
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0047 0.0005 0.0018
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0311 0.081 0.5949
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0088 0.013 0.0905
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0429 0.117 0.1647
Loa Loa (eye worm) hypothetical protein 0.0047 0.0005 0.0005
Schistosoma mansoni steroid dehydrogenase 0.0047 0.0005 0.0003
Echinococcus multilocularis aryl hydrocarbon receptor 0.0092 0.0142 0.0194
Trypanosoma brucei metacaspase 5, putative 0.0312 0.0813 0.5845
Mycobacterium ulcerans DNA polymerase IV 0.009 0.0136 0.0972
Onchocerca volvulus 0.0202 0.0477 0.2555
Leishmania major quinonoid dihydropteridine reductase 0.0047 0.0005 0.0018
Loa Loa (eye worm) RGC/RGC protein kinase 0.0093 0.0145 0.0145
Leishmania major hypothetical protein, conserved 0.0047 0.0005 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.0314 0.0819 0.5875
Trypanosoma brucei DNA polymerase kappa, putative 0.009 0.0136 0.0966
Mycobacterium tuberculosis Probable oxidoreductase 0.0047 0.0005 0.002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0047 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0093 0.0145 0.0145
Schistosoma mansoni glutamate receptor NMDA 0.1994 0.5947 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0047 0.0005 0.0005
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0092 0.0142 0.0992
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0062 0.0428
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0394 0.281
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0311 0.081 0.5949
Trypanosoma brucei short-chain dehydrogenase, putative 0.0047 0.0005 0.0018
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0102 0.0173 0.0237
Echinococcus granulosus metabotropic glutamate receptor 2 0.0093 0.0145 0.0198
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0312 0.0813 0.5837
Echinococcus multilocularis ubiquitin specific protease 41 0.0501 0.139 0.1957
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0047 0.0005 0.0005
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0311 0.081 0.5949
Echinococcus multilocularis musashi 0.0085 0.012 0.0163
Echinococcus granulosus lamin 0.0085 0.012 0.0163
Echinococcus granulosus caspase 3 0.0454 0.1247 0.1755
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0314 0.0819 0.5875
Echinococcus granulosus aryl hydrocarbon receptor 0.0092 0.0142 0.0194
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0102 0.0173 0.0237
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0044 0.0285
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0047 0.0005 0.0005
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0047 0.0005 0.002
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0311 0.081 0.581
Trichomonas vaginalis bromodomain-containing protein, putative 0.0088 0.013 0.0905
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0047 0.0005 0.0005
Echinococcus multilocularis transfer RNA-Lys 0.0262 0.0662 0.0928
Onchocerca volvulus Cell death protein 3 homolog 0.0653 0.1853 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.009 0.0136 0.0949
Trypanosoma cruzi metacaspase 5, putative 0.0312 0.0813 0.5837
Echinococcus multilocularis survival motor neuron protein 1 0.0736 0.2107 0.297
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0311 0.081 0.5818
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0062 0.0411
Trypanosoma brucei DNA polymerase IV, putative 0.009 0.0136 0.0966
Plasmodium falciparum metacaspase 1 0.0312 0.0813 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0311 0.081 0.5949
Trypanosoma cruzi metacaspase, putative 0.0312 0.0813 0.5837
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0092 0.0142 0.0142
Leishmania major cathepsin L-like protease 0.0066 0.0062 0.0428
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0047 0.0005 0.0005
Plasmodium vivax serine/threonine kinase-1, putative 0.0062 0.0049 0.0545
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0092 0.0142 0.0992
Trypanosoma cruzi extracellular receptor, putative 0.0093 0.0145 0.1013
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0249 0.062 0.087
Loa Loa (eye worm) hypothetical protein 0.0058 0.0039 0.0039
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0047 0.0005 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0314 0.0819 0.1372
Brugia malayi acetyltransferase, GNAT family protein 0.03 0.0776 0.0776
Echinococcus granulosus ubiquitin specific protease 41 0.0501 0.139 0.1957
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0311 0.081 0.5949
Schistosoma mansoni short chain dehydrogenase 0.0047 0.0005 0.0003
Loa Loa (eye worm) dehydrogenase 0.0047 0.0005 0.0005
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0088 0.013 0.155
Brugia malayi polk-prov protein 0.0068 0.0069 0.0069
Schistosoma mansoni survival motor neuron protein 0.015 0.0319 0.0532
Trypanosoma brucei cytochrome P450, putative 0.049 0.1358 0.9767
Echinococcus multilocularis caspase 2 0.0653 0.1853 0.2612
Echinococcus multilocularis caspase 3 0.0454 0.1247 0.1755
Giardia lamblia Histone acetyltransferase GCN5 0.0081 0.0108 0.076
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0429 0.117 0.8417
Echinococcus granulosus survival motor neuron protein 1 0.0736 0.2107 0.297
Echinococcus granulosus inositol monophosphatase 1 0.0075 0.0089 0.0119
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0311 0.081 0.5949
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0311 0.081 0.5949
Trypanosoma cruzi metacaspase, putative 0.0312 0.0813 0.5837
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.285 0.402
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0766 0.2199 0.31
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0069 0.011
Loa Loa (eye worm) hypothetical protein 0.0093 0.0145 0.0145
Schistosoma mansoni glutamate receptor kainate 0.0182 0.0415 0.0693
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0047 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0501 0.139 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0311 0.081 0.6313
Echinococcus multilocularis mitogen activated protein kinase 3 0.0314 0.0819 0.115
Schistosoma mansoni metabotropic glutamate receptor 0.0093 0.0145 0.0239
Leishmania major pteridine reductase 1 0.0047 0.0005 0.0018
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0047 0.0005 0.002
Echinococcus multilocularis nmda type glutamate receptor 0.1812 0.5393 0.7612
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0312 0.0813 0.5837
Schistosoma mansoni glutamate receptor AMPA 0.0182 0.0415 0.0693
Schistosoma mansoni intermediate filament proteins 0.0085 0.012 0.0197
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0093 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0093 0.0145 0.0145
Giardia lamblia Kinase, CMGC CLK 0.0062 0.0049 0.0336
Loa Loa (eye worm) oxidoreductase 0.0047 0.0005 0.0005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0429 0.117 0.8615
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0069 0.011
Trypanosoma cruzi cytochrome P450, putative 0.049 0.1358 0.9767
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0311 0.081 0.6313
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0501 0.139 1
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0047 0.0005 0.002
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0182 0.0415 0.058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0062 0.0428
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0095 0.0152 0.1064
Plasmodium falciparum metacaspase-like protein 0.0312 0.0813 1
Trypanosoma brucei DNA polymerase IV, putative 0.0076 0.0092 0.0647
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0311 0.081 0.6313
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0047 0.0005 0.002
Schistosoma mansoni inositol monophosphatase 0.0075 0.0089 0.0144
Schistosoma mansoni hypothetical protein 0.0182 0.0415 0.0693
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0429 0.117 0.1647
Loa Loa (eye worm) hypothetical protein 0.0047 0.0005 0.0005
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0766 0.2199 0.31
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0047 0.0005 0.002
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0168 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0068 0.0069 0.0069
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0311 0.081 0.6313
Schistosoma mansoni hypothetical protein 0.0311 0.081 0.1357
Echinococcus multilocularis NMDA receptor 0.0182 0.0415 0.058
Loa Loa (eye worm) hypothetical protein 0.0092 0.0142 0.0142
Leishmania major hypothetical protein, conserved 0.0047 0.0005 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0367 0.2613
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0089 0.0624
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0311 0.081 0.5949
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0314 0.0819 0.0819
Schistosoma mansoni lipoxygenase 0.0174 0.0392 0.0654
Echinococcus granulosus single minded 2 0.0262 0.0662 0.0928
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0092 0.0142 0.0992
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0314 0.0819 0.5875
Toxoplasma gondii cytochrome p450 superfamily protein 0.0311 0.081 0.6801
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0049 0.0077
Trypanosoma brucei Metacaspase-4 0.0312 0.0813 0.5845
Trypanosoma brucei short-chain dehydrogenase, putative 0.0047 0.0005 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0367 0.2613
Loa Loa (eye worm) hypothetical protein 0.0202 0.0477 0.0477
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0062 0.0049 0.0336
Trypanosoma brucei protein kinase, putative 0.0314 0.0819 0.5883
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0062 0.0428
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0047 0.0005 0.0018
Schistosoma mansoni tyrosine kinase 0.0093 0.0145 0.0239
Onchocerca volvulus 0.0262 0.0662 0.3554
Leishmania major short chain dehydrogenase/reductase, putative 0.0047 0.0005 0.0018
Echinococcus granulosus glutamate receptor subunit protein glur 0.0182 0.0415 0.058
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0501 0.139 0.2334
Echinococcus granulosus glutamate receptor NMDA 0.1719 0.5108 0.721
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0275 0.0699 0.0981
Trypanosoma cruzi metacaspase 5, putative 0.0312 0.0813 0.5837
Leishmania major cytochrome p450-like protein 0.049 0.1358 0.9767
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0142 0.0992
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0312 0.0813 0.1363
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0047 0.0005 0.0005
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0047 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0093 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0047 0.0005 0.0005
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0314 0.0819 0.6877
Schistosoma mansoni hypothetical protein 0.015 0.0319 0.0532
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0275 0.0699 0.0981
Mycobacterium leprae Conserved hypothetical protein 0.0311 0.081 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0093 0.0145 0.0759
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0311 0.081 0.5949
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0311 0.081 0.6313
Echinococcus multilocularis receptor type guanylyl cyclase 0.0093 0.0145 0.0198
Schistosoma mansoni short chain dehydrogenase 0.0047 0.0005 0.0003
Mycobacterium ulcerans putative regulatory protein 0.0262 0.0662 0.4855
Trypanosoma cruzi metacaspase, putative 0.0312 0.0813 0.5837
Schistosoma mansoni short chain dehydrogenase 0.0047 0.0005 0.0003
Echinococcus granulosus atrial natriuretic peptide receptor 0.0093 0.0145 0.0198
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0173 0.0285
Schistosoma mansoni short chain dehydrogenase 0.0047 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0047 0.0005 0.0005
Echinococcus granulosus histone acetyltransferase KAT2B 0.0088 0.013 0.0177
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0047 0.0005 0.0001
Echinococcus multilocularis glutamate receptor NMDA 0.1719 0.5108 0.721
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0501 0.139 0.1957
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.0069 0.0484
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0092 0.0142 0.0992
Trypanosoma brucei DNA polymerase kappa, putative 0.009 0.0136 0.0966
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0632 0.4527
Schistosoma mansoni short chain dehydrogenase 0.0047 0.0005 0.0003
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0062 0.0049 0.0372
Loa Loa (eye worm) glutamate receptor 1 0.0182 0.0415 0.0415
Mycobacterium leprae Possible regulatory protein 0.0092 0.0142 0.1707
Brugia malayi bHLH-PAS transcription factor 0.0262 0.0662 0.0662
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0465 0.1281 1
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.0367 0.1959
Echinococcus granulosus nmda type glutamate receptor 0.1812 0.5393 0.7612
Entamoeba histolytica hypothetical protein 0.0093 0.0145 0.1013
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0047 0.0005 0.0003
Brugia malayi Receptor family ligand binding region containing protein 0.0093 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0047 0.0005 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.009 0.0136 0.0949
Mycobacterium ulcerans aldehyde dehydrogenase 0.0435 0.1188 0.8747
Schistosoma mansoni steroid dehydrogenase 0.0047 0.0005 0.0003
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0047 0.0005 0.0005
Loa Loa (eye worm) inositol-1 0.0075 0.0089 0.0089
Brugia malayi metabotropic glutamate receptor type 2 0.0093 0.0145 0.0145
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0047 0.0005 0.002
Brugia malayi Cell death protein 3 precursor 0.0653 0.1853 0.1853
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0047 0.0005 0.0001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0312 0.0813 0.5837
Leishmania major hypothetical protein, conserved 0.0047 0.0005 0.0018
Echinococcus multilocularis lamin 0.0085 0.012 0.0163
Plasmodium vivax hypothetical protein, conserved 0.0312 0.0813 1
Trypanosoma brucei DNA polymerase kappa, putative 0.009 0.0136 0.0966
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0047 0.0005 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0062 0.0428
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0093 0.0145 0.0145
Leishmania major quinonoid dihydropteridine reductase 0.0047 0.0005 0.0018
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0465 0.1281 0.9435
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.015 0.0319 0.0319
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0311 0.081 0.6313
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0093 0.0145 0.0198
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0047 0.0005 0.002
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0182 0.0415 0.058
Trypanosoma brucei short-chain dehydrogenase, putative 0.0047 0.0005 0.0018
Schistosoma mansoni glutamate receptor kainate 0.0182 0.0415 0.0693
Leishmania major cytochrome p450-like protein 0.0311 0.081 0.5818
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0501 0.139 0.139
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0182 0.0415 0.058
Mycobacterium ulcerans aldehyde dehydrogenase 0.0435 0.1188 0.8747
Loa Loa (eye worm) oxidoreductase 0.0047 0.0005 0.0005
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0501 0.139 0.1957
Echinococcus multilocularis apoptotic protease activating factor 1 0.0341 0.0901 0.1266
Chlamydia trachomatis glutamine binding protein 0.0465 0.1281 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0314 0.0819 0.5875
Schistosoma mansoni aryl hydrocarbon receptor 0.0354 0.0943 0.1581
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0311 0.081 0.5949
Schistosoma mansoni short chain dehydrogenase 0.0047 0.0005 0.0003
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0182 0.0415 0.058
Echinococcus granulosus histone acetyltransferase KAT2B 0.0291 0.075 0.1053
Echinococcus granulosus glutamate receptor 2 0.0275 0.0699 0.0981
Brugia malayi hypothetical protein 0.0047 0.0005 0.0005
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.03 0.0776 0.109
Brugia malayi intermediate filament protein 0.0085 0.012 0.012
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0312 0.0813 0.5837
Trichomonas vaginalis conserved hypothetical protein 0.0312 0.0813 0.5837
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0182 0.0415 0.058
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0092 0.0142 0.0194
Leishmania major quinonoid dihydropteridine reductase 0.0047 0.0005 0.0018
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0314 0.0819 0.5875
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0089 0.0624
Giardia lamblia Reductase, putative 0.0047 0.0005 0.0018
Leishmania major cathepsin L-like protease 0.0066 0.0062 0.0428
Schistosoma mansoni caspase-7 (C14 family) 0.0653 0.1853 0.3113
Brugia malayi hypoxia-induced factor 1 0.1097 0.3209 0.3209
Leishmania major oxidoreductase-like protein 0.0047 0.0005 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0367 0.2613
Schistosoma mansoni steroid dehydrogenase 0.0047 0.0005 0.0003
Echinococcus multilocularis nmda type glutamate receptor 0.2366 0.7083 1
Brugia malayi Guanylyl cyclase protein 23 0.0093 0.0145 0.0145
Loa Loa (eye worm) acetyltransferase 0.03 0.0776 0.0776
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0047 0.0005 0.0018
Loa Loa (eye worm) follicle stimulating hormone receptor 0.3321 1 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.012 0.012
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0311 0.081 0.6313
Leishmania major quinonoid dihydropteridine reductase 0.0047 0.0005 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0632 0.4527
Brugia malayi dehydrogenases, short chain protein 9 0.0047 0.0005 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0632 0.4527
Trichomonas vaginalis conserved hypothetical protein 0.0312 0.0813 0.5837
Loa Loa (eye worm) hypothetical protein 0.0047 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.009 0.0136 0.0966
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0062 0.0049 0.0318
Echinococcus granulosus caspase 8 0.0312 0.0813 0.1142
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0182 0.0415 0.058
Loa Loa (eye worm) hypothetical protein 0.0093 0.0145 0.0145
Schistosoma mansoni caspase-3 (C14 family) 0.0766 0.2199 0.3695
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0047 0.0005 0.0005
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0312 0.0813 0.5837
Schistosoma mansoni short chain dehydrogenase 0.0047 0.0005 0.0003
Loa Loa (eye worm) oxidoreductase 0.0047 0.0005 0.0005
Leishmania major short chain dehydrogenase, putative 0.0047 0.0005 0.0018
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0312 0.0813 0.5837
Giardia lamblia Hypothetical protein 0.0047 0.0005 0.0018
Echinococcus multilocularis dual specificity protein kinase clk2 0.0062 0.0049 0.0062
Leishmania major extracellular receptor, putative 0.0093 0.0145 0.1029
Loa Loa (eye worm) hypothetical protein 0.0653 0.1853 0.1853
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0709 0.5525
Plasmodium falciparum histone acetyltransferase GCN5 0.0081 0.0108 0.1272
Brugia malayi Glutamate receptor 2 precursor 0.0182 0.0415 0.0415
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0311 0.081 0.6313
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0088 0.013 0.1059
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0092 0.0142 0.1008
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0062 0.0049 0.0318
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0311 0.081 0.6313
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0047 0.0005 0.002
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0311 0.081 0.5949
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0047 0.0005 0.0021
Trypanosoma cruzi metacaspase, putative 0.0312 0.0813 0.5837
Brugia malayi cytochrome P450 0.0311 0.081 0.081
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0093 0.0145 0.0145
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.0065 0.0748
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0275 0.0699 0.0981
Trichomonas vaginalis conserved hypothetical protein 0.0312 0.0813 0.5837
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0312 0.0813 0.0813
Brugia malayi hypothetical protein 0.0093 0.0145 0.0145
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0062 0.0428
Loa Loa (eye worm) hypothetical protein 0.0068 0.0069 0.0069
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0311 0.081 0.6313
Brugia malayi Metabotropic glutamate receptor precursor. 0.0093 0.0145 0.0145
Schistosoma mansoni caspase-7 (C14 family) 0.0766 0.2199 0.3695
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0093 0.0145 0.0198
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0047 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0501 0.139 0.139
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0047 0.0005 0.0005
Giardia lamblia Kinase, CMGC MAPK 0.0314 0.0819 0.5883
Brugia malayi hypothetical protein 0.1189 0.349 0.349
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0429 0.117 0.1964
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0089 0.0607
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0182 0.0415 0.058
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0312 0.0813 0.6832
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0632 0.4527
Schistosoma mansoni short chain dehydrogenase 0.0047 0.0005 0.0003
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0465 0.1281 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0005 0.0005
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0092 0.0142 0.0194
Trypanosoma brucei oxidoreductase-like protein 0.0047 0.0005 0.0018
Echinococcus granulosus intermediate filament protein 0.0085 0.012 0.0163
Echinococcus granulosus metabotropic glutamate receptor 5 0.0093 0.0145 0.0198
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0092 0.0142 0.0992
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0312 0.0813 0.5837
Trichomonas vaginalis guanylate cyclase, putative 0.0092 0.0142 0.0992
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0047 0.0005 0.002
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.009 0.0136 0.0949
Mycobacterium leprae conserved hypothetical protein 0.0047 0.0005 0.0001
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0647 0.1836 0.2587
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0075 0.0089 0.071
Schistosoma mansoni steroid dehydrogenase 0.0047 0.0005 0.0003
Leishmania major dehydrogenase-like protein 0.0047 0.0005 0.0018
Leishmania major 3-keto-dihydrosphingosine reductase 0.0047 0.0005 0.0018
Schistosoma mansoni metabotropic glutamate receptor 0.0093 0.0145 0.0239
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0047 0.0005 0.0018
Trypanosoma brucei metacaspase MCA2 0.0312 0.0813 0.5845
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0047 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0083 0.0116 0.0116
Echinococcus granulosus receptor type guanylyl cyclase 0.0093 0.0145 0.0198
Onchocerca volvulus 0.0085 0.012 0.0625
Schistosoma mansoni tyrosine kinase 0.0093 0.0145 0.0239
Schistosoma mansoni short chain dehydrogenase 0.0047 0.0005 0.0003
Mycobacterium tuberculosis Probable oxidoreductase 0.0047 0.0005 0.002
Leishmania major cathepsin L-like protease 0.0066 0.0062 0.0428
Echinococcus granulosus glutamate NMDA receptor subunit 0.0182 0.0415 0.058
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0367 0.2613
Echinococcus multilocularis dna polymerase kappa 0.009 0.0136 0.0186
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0501 0.139 1
Loa Loa (eye worm) hypothetical protein 0.018 0.0409 0.0409
Brugia malayi hypothetical protein 0.0047 0.0005 0.0005
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0047 0.0005 0.002
Echinococcus granulosus mitogen activated protein kinase 0.0314 0.0819 0.115
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0047 0.0005 0.0005
Onchocerca volvulus 0.0092 0.0142 0.0743
Schistosoma mansoni cellular tumor antigen P53 0.0202 0.0477 0.0797
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.0069 0.0484
Schistosoma mansoni lamin 0.0085 0.012 0.0197
Brugia malayi Dehydrogenases, short chain protein 30 0.0047 0.0005 0.0005
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0311 0.081 0.6313
Echinococcus multilocularis glutamate receptor 2 0.0182 0.0415 0.058
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0095 0.0152 0.1064
Brugia malayi Glutamate receptor 1 precursor 0.0182 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.0168 0.0373 0.0373
Loa Loa (eye worm) dehydrogenase 0.0047 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0093 0.0145 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.009 0.0136 0.0966
Schistosoma mansoni carbonyl reductase 0.0047 0.0005 0.0003
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0047 0.0005 0.0001
Echinococcus granulosus glutamate receptor 2 0.0093 0.0145 0.0198
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.0632 0.0632
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0062 0.0428
Echinococcus granulosus dual specificity protein kinase clk2 0.0062 0.0049 0.0062
Leishmania major protein kinase, putative 0.0095 0.0152 0.108
Schistosoma mansoni short chain dehydrogenase 0.0047 0.0005 0.0003
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0092 0.0142 0.1075
Loa Loa (eye worm) hypothetical protein 0.0047 0.0005 0.0005
Onchocerca volvulus 0.0093 0.0145 0.0759
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0062 0.0411
Schistosoma mansoni lamin 0.0085 0.012 0.0197
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0049 0.0077
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0095 0.0152 0.1064
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0089 0.0607
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0047 0.0005 0.0018
Loa Loa (eye worm) hypothetical protein 0.0341 0.0901 0.0901
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0142 0.0992
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0047 0.0005 0.0005
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0068 0.0069 0.0462
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0047 0.0005 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0311 0.081 0.6313
Loa Loa (eye worm) oxidoreductase 0.0047 0.0005 0.0005
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0311 0.081 0.581
Trypanosoma brucei short-chain dehydrogenase, putative 0.0047 0.0005 0.0018
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0311 0.081 0.5949
Schistosoma mansoni steroid dehydrogenase 0.0047 0.0005 0.0003
Loa Loa (eye worm) RGC/RGC protein kinase 0.0093 0.0145 0.0145
Mycobacterium tuberculosis Possible oxidoreductase 0.0047 0.0005 0.002
Echinococcus multilocularis caspase 0.0766 0.2199 0.31
Schistosoma mansoni short chain dehydrogenase 0.0047 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0047 0.0005 0.0005
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0047 0.0005 0.0018
Loa Loa (eye worm) hypothetical protein 0.0093 0.0145 0.0145
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0275 0.0699 0.0981
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0311 0.081 0.6313
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0062 0.0411
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0047 0.0005 0.002
Onchocerca volvulus 0.0093 0.0145 0.0759
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0047 0.0005 0.0001
Loa Loa (eye worm) glutamate receptor 2 0.0182 0.0415 0.0415
Brugia malayi oxidoreductase 0.0047 0.0005 0.0005
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0047 0.0005 0.002
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0275 0.0699 0.0981
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0005 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0312 0.0813 0.5837
Onchocerca volvulus 0.0168 0.0373 0.199
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0311 0.081 0.5949
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0075 0.0089 0.0607
Loa Loa (eye worm) hypothetical protein 0.0047 0.0005 0.0005
Echinococcus granulosus tyrosine kinase 0.0093 0.0145 0.0198
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0047 0.0005 0.0005
Brugia malayi MAP kinase sur-1 0.0314 0.0819 0.0819
Trypanosoma brucei DNA polymerase IV, putative 0.009 0.0136 0.0966
Brugia malayi Dehydrogenases, short chain protein 2 0.0047 0.0005 0.0005
Brugia malayi hypothetical protein 0.0736 0.2107 0.2107
Schistosoma mansoni hypothetical protein 0.0341 0.0901 0.151
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0501 0.139 0.2334
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0173 0.0285
Schistosoma mansoni steroid dehydrogenase 0.0047 0.0005 0.0003
Brugia malayi Intermediate filament tail domain containing protein 0.0085 0.012 0.012
Schistosoma mansoni inositol monophosphatase 0.0075 0.0089 0.0144
Echinococcus granulosus nmda type glutamate receptor 0.2366 0.7083 1
Plasmodium vivax metacaspase 1, putative 0.0312 0.0813 1
Brugia malayi Retinol dehydrogenase 12 0.0047 0.0005 0.0005
Trypanosoma brucei metacaspase 0.0312 0.0813 0.5845
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0311 0.081 0.6313
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0062 0.0428
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0093 0.0145 0.0145
Schistosoma mansoni single-minded 0.0354 0.0943 0.1581
Schistosoma mansoni glutamate receptor kainate 0.0182 0.0415 0.0693
Echinococcus multilocularis 0.0058 0.0039 0.0048
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0501 0.139 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0047 0.0005 0.002
Leishmania major protein kinase, putative 0.0062 0.0049 0.0336
Echinococcus multilocularis tyrosine kinase 0.0093 0.0145 0.0198
Echinococcus granulosus cytochrome P450 2K1 0.0311 0.081 0.1137
Schistosoma mansoni short chain dehydrogenase 0.0047 0.0005 0.0003
Schistosoma mansoni short chain dehydrogenase 0.0047 0.0005 0.0003
Onchocerca volvulus 0.015 0.0319 0.1701
Brugia malayi Inositol-1 0.0075 0.0089 0.0089
Plasmodium falciparum protein serine/threonine kinase-1 0.0062 0.0049 0.0545
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0062 0.0049 0.0049
Trichomonas vaginalis CMGC family protein kinase 0.0314 0.0819 0.5875

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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