Detailed information for compound 1231289

Basic information

Technical information
  • TDR Targets ID: 1231289
  • Name: N-(2,4-dimethoxyphenyl)quinazoline-2,4-diamin e hydrochloride
  • MW: 332.785 | Formula: C16H17ClN4O2
  • H donors: 2 H acceptors: 2 LogP: 3.81 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)ccc1Nc1nc(N)c2c(n1)cccc2.Cl
  • InChi: 1S/C16H16N4O2.ClH/c1-21-10-7-8-13(14(9-10)22-2)19-16-18-12-6-4-3-5-11(12)15(17)20-16;/h3-9H,1-2H3,(H3,17,18,19,20);1H
  • InChiKey: BROTWZHYVQOHSN-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • (4-aminoquinazolin-2-yl)-(2,4-dimethoxyphenyl)amine hydrochloride
  • N*2*-(2,4-Dimethoxy-phenyl)-quinazoline-2,4-diamine
  • MLS001206613
  • SMR000524059

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Mus musculus transient receptor potential cation channel, subfamily C, member 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Transient-receptor-potential like protein Get druggable targets OG5_128782 All targets in OG5_128782
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Short transient receptor potential channel 5, putative Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus transient receptor potential gamma protein Get druggable targets OG5_128782 All targets in OG5_128782
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni transient receptor potential channel Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis transient receptor potential ion channel A Get druggable targets OG5_128782 All targets in OG5_128782
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis transient receptor potential gamma protein Get druggable targets OG5_128782 All targets in OG5_128782
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus TRP transient receptor potential channel Get druggable targets OG5_128782 All targets in OG5_128782
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Short transient receptor potential channel 5, putative Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus transient receptor potential ion channel A Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis TRP (transient receptor potential) channel Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni transient receptor potential channel 4 Get druggable targets OG5_128782 All targets in OG5_128782
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K05328 transient receptor potential cation channel, subfamily C,, putative Get druggable targets OG5_128782 All targets in OG5_128782
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K05328 transient receptor potential cation channel, subfamily C,, putative Get druggable targets OG5_128782 All targets in OG5_128782
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Transient receptor potential-gamma protein, putative Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 654 aa 613 aa 51.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Echinococcus multilocularis short transient receptor potential channel 6 transient receptor potential cation channel, subfamily C, member 4 890 aa 799 aa 31.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ran 0.0021 0.01 0.0258
Entamoeba histolytica peptidase, C54 family 0.0119 0.0796 0.3134
Echinococcus multilocularis jumonji domain containing 1A 0.0009 0.0016 0.0011
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0467 0.3275 0.3275
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0203 0.1078
Onchocerca volvulus 0.0035 0.02 0.02
Schistosoma mansoni hypothetical protein 0.0015 0.0055 0.013
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0213 0.1464 0.6305
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0101 0.0872
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.004 0.009
Treponema pallidum heat shock protein 90 0.0042 0.0248 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0153 0.0624
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0247 0.2133
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0015 0.0055 0.0632
Trypanosoma brucei heat shock protein, putative 0.0045 0.0268 0.1124
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0186 0.077
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0119 0.0796 0.3413
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.01 0.01
Echinococcus multilocularis survival motor neuron protein 1 0.0262 0.1812 0.261
Loa Loa (eye worm) histone methyltransferase 0.002 0.0089 0.0089
Leishmania major heat shock protein 83-1 0.0045 0.0268 0.1124
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0015 0.0055 0.0632
Leishmania major phospholipase A1, putative 0.0333 0.2317 1
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0239 0.0334
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0045 0.0237
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.0501 0.0712
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0248 0.1322
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0156 0.1056 0.2959
Onchocerca volvulus 0.0333 0.2317 0.2317
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0009 0.0096
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0022 0.0067
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0015 0.0055 0.0632
Brugia malayi Cytochrome P450 family protein 0.0015 0.0055 0.0167
Echinococcus multilocularis nibrin 0.0012 0.0033 0.0036
Plasmodium vivax heat shock protein 86, putative 0.0045 0.0268 0.2313
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0015 0.0055 0.0632
Schistosoma mansoni jumonji domain containing protein 0.0009 0.0016 0.0021
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0226 0.0613
Brugia malayi Cytochrome P450 family protein 0.0015 0.0055 0.0167
Leishmania major heat shock protein 83-1 0.0045 0.0268 0.1124
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0012 0.0033 0.1033
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.0248 0.1039
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.0248 0.2878
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0042 0.0248 1
Plasmodium vivax heat shock protein, putative 0.017 0.1159 1
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0268 0.1124
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0017 0.0146
Toxoplasma gondii Hsp90 domain-containing protein 0.017 0.1159 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0033
Mycobacterium ulcerans heat shock protein 90 0.0042 0.0248 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0153 0.6001
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0015 0.0055 0.1926
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0186 0.0569
Brugia malayi jmjC domain containing protein 0.0009 0.0016 0.0049
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0015 0.0055 0.1926
Entamoeba histolytica peptidase, C54 family 0.0046 0.0279 0.1077
Schistosoma mansoni transient receptor potential channel 4 0.0117 0.0783 0.2187
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0055 0.0055
Leishmania major heat shock protein 83-1 0.0045 0.0268 0.1124
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0022 0.0038
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.0859 0.2624
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0312 0.166
Leishmania major heat shock protein 83-1 0.0045 0.0268 0.1124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0045 0.0237
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0044 0.014
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0312 0.0439
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0033 0.0176
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0153 0.0573
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0134 0.1159
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.01 0.0861
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0089 0.0116
Schistosoma mansoni topbp1 0.0012 0.0033 0.007
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0186 0.1608
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0268 0.1033
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0033 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0033 0.0176
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0009 0.0026
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0063 0.0079
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.0268 0.2313
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0055 0.02
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0009 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0045 0.0237
Plasmodium falciparum JmjC domain-containing protein, putative 0.0009 0.0016 0.0139
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.01 0.0396
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0274 0.146
Trypanosoma brucei heat shock protein, putative 0.0045 0.0268 0.1124
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0015 0.0055 0.0632
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0203 0.0548
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0045 0.0237
Echinococcus granulosus snurportin 1 0.0308 0.2142 0.6023
Echinococcus multilocularis dnaJ subfamily B 0.0439 0.3075 0.4436
Loa Loa (eye worm) hypothetical protein 0.0029 0.0153 0.0153
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0015 0.0055 0.1926
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.0788 0.6799
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0182 0.0489
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0203 0.0841
Loa Loa (eye worm) hypothetical protein 0.0074 0.0473 0.0473
Echinococcus multilocularis 0.0015 0.0055 0.0067
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0009 0.0016 0.0139
Brugia malayi TAR-binding protein 0.0128 0.0859 0.2624
Onchocerca volvulus 0.0012 0.0033 0.0033
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0203 0.1078
Brugia malayi AF-10 protein 0.001 0.0017 0.0052
Trypanosoma brucei heat shock protein, putative 0.0045 0.0268 0.1124
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0093 0.1072
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0101 1
Leishmania major heat shock protein 83-1 0.0045 0.0268 0.1124
Onchocerca volvulus 0.0053 0.0329 0.0329
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.004 0.0046
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0633 0.1763
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0063 0.0079
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0158 0.1359
Brugia malayi Importin beta-1 subunit 0.0029 0.0154 0.047
Trichomonas vaginalis ran, putative 0.0021 0.01 0.0531
Schistosoma mansoni inositol monophosphatase 0.0036 0.0203 0.0548
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0055 0.0055
Echinococcus multilocularis Peptidase C54 0.0119 0.0796 0.114
Mycobacterium leprae Conserved hypothetical protein 0.0015 0.0055 0.1926
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0158 0.0216
Leishmania major hypothetical protein, conserved 0.0051 0.0315 0.1326
Plasmodium vivax endoplasmin, putative 0.0045 0.0268 0.2313
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0033 0.0107
Brugia malayi Peptidase family C54 containing protein 0.0119 0.0796 0.2432
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0101 0.0401
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0015 0.0055 0.0632
Brugia malayi Hsp90 protein 0.003 0.0161 0.0491
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0247 0.095
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0119 0.0796 0.424
Trypanosoma brucei heat shock protein, putative 0.0045 0.0268 0.1124
Leishmania major lanosterol synthase, putative 0.0193 0.1324 0.5697
Plasmodium vivax JmjC domain containing protein 0.0009 0.0016 0.0139
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0009 0.0096
Schistosoma mansoni cpg binding protein 0.0063 0.0397 0.1097
Loa Loa (eye worm) cytochrome P450 0.0015 0.0055 0.0055
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0186 0.0502
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0203 0.0281
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.02 0.054
Schistosoma mansoni hypothetical protein 0.0049 0.0296 0.0812
Brugia malayi Bromodomain containing protein 0.0033 0.0185 0.0564
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0055 0.02
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0009 0.0096
Schistosoma mansoni hypothetical protein 0.0043 0.0258 0.0704
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0176 0.2039
Schistosoma mansoni DNA helicase recq5 0.001 0.0022 0.0038
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0158 0.0158
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0153 0.6001
Echinococcus multilocularis heat shock protein 90 0.0038 0.0222 0.0309
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0015 0.0055 0.0632
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.01 0.0396
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0033 0.0176
Plasmodium falciparum phd finger protein, putative 0.0029 0.0158 0.1359
Schistosoma mansoni cpg binding protein 0.0063 0.0397 0.1097
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0315 0.2714
Giardia lamblia PHD finger protein 15 0.0029 0.0158 0.0542
Trypanosoma brucei heat shock protein, putative 0.0045 0.0268 0.1124
Brugia malayi Endoplasmin precursor 0.0045 0.0268 0.0819
Trypanosoma cruzi Emopamil binding protein, putative 0.0134 0.0901 0.3864
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0113 0.0151
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0119 0.0796 0.3413
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0203 0.7874
Echinococcus multilocularis transient receptor potential gamma protein 0.0117 0.0783 0.1121
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0009 0.0026
Loa Loa (eye worm) hypothetical protein 0.0013 0.0041 0.0041
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0186 0.077
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0186 0.1608
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0015 0.0055 0.0632
Loa Loa (eye worm) hypothetical protein 0.0021 0.0101 0.0101
Toxoplasma gondii cytochrome p450 superfamily protein 0.0015 0.0055 0.0472
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0101 0.3853
Echinococcus granulosus phd:f box containing protein 0.0009 0.0016 0.0021
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0101 0.0872
Schistosoma mansoni hypothetical protein 0.0053 0.0329 0.0904
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0119 0.0796 0.424
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0015 0.0055 0.1926
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0362 0.2522 1
Brugia malayi RNA binding protein 0.0128 0.0859 0.2624
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0296 0.0904
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0101 0.0101
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.1046 0.3195
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0795 0.1138
Echinococcus multilocularis cpg binding protein 0.0063 0.0397 0.0562
Echinococcus granulosus cpg binding protein 0.0063 0.0397 0.1097
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0055 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0033 0.0176
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0009 0.0073
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0274 0.2367
Giardia lamblia Replication factor C, subunit 1 0.0012 0.0033 0.0045
Echinococcus granulosus dnaJ subfamily B 0.0439 0.3075 0.8658
Leishmania major heat shock protein 83-1 0.0045 0.0268 0.1124
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0045 0.0237
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6921 1
Echinococcus granulosus importin subunit beta 1 0.0029 0.0154 0.0411
Echinococcus granulosus tar DNA binding protein 0.0128 0.0859 0.2402
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0022
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0222 0.1181
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0009 0.0016 0.0033
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0213 0.1464 0.6305
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0067 0.0582
Leishmania major heat shock protein 83-1 0.0045 0.0268 0.1124
Leishmania major importin beta-1 subunit, putative 0.0023 0.0115 0.0462
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0015 0.0055 0.0632
Brugia malayi Transient-receptor-potential like protein 0.0044 0.0259 0.0791
Loa Loa (eye worm) jmjC domain-containing protein 0.0009 0.0016 0.0016
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0055 0.02
Brugia malayi jmjC domain containing protein 0.0009 0.0016 0.0049
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0015 0.0055 0.1926
Echinococcus granulosus transient receptor potential ion channel A 0.0113 0.0755 0.2109
Echinococcus granulosus bloom syndrome protein 0.0025 0.0126 0.0333
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0009 0.0016 0.0021
Leishmania major heat shock protein 83-1 0.0045 0.0268 0.1124
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0213 0.1464 0.6305
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0258 0.0704
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.0033 0.0107
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0033 0.0102
Loa Loa (eye worm) hypothetical protein 0.0029 0.0153 0.0153
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0044 0.0231
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0238 0.1645 0.1645
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0009 0.0073
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0161 0.066
Brugia malayi Pre-SET motif family protein 0.0238 0.1645 0.5023
Schistosoma mansoni transient receptor potential channel 0.0078 0.0501 0.139
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0015 0.0055 0.0632
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0153 0.1765
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0161 0.043
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0009 0.0009
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0153 0.6001
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0153 0.6001
Loa Loa (eye worm) hypothetical protein 0.0051 0.0315 0.0315
Echinococcus multilocularis heat shock protein 90 0.0045 0.0268 0.0376
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0248 0.1322
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0009 0.0096
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0203 0.1749
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.01 0.0861
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0126 0.0386
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0115 0.0612
Loa Loa (eye worm) hypothetical protein 0.0008 0.0009 0.0009
Schistosoma mansoni inositol monophosphatase 0.0036 0.0203 0.0548
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0373 0.0373
Entamoeba histolytica hypothetical protein 0.0043 0.0258 0.0992
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0009 0.0096
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0015 0.0055 0.1926
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0859 0.2402
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0015 0.0055 0.0632
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0153 0.6001
Echinococcus multilocularis protein dispatched 1 0.0058 0.0363 0.0513
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.0699 0.2134
Onchocerca volvulus 0.0029 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0104 0.0687 0.0687
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0101 0.0134
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0015 0.0055 0.1926
Schistosoma mansoni hypothetical protein 0.0049 0.0299 0.082
Onchocerca volvulus 0.006 0.0373 0.0373
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0203 0.8093
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0274 0.2367
Echinococcus multilocularis transient receptor potential ion channel A 0.0113 0.0755 0.108
Trypanosoma cruzi lanosterol synthase, putative 0.0193 0.1324 0.5697
Brugia malayi DKFZp564C0469 protein 0.0012 0.0033 0.0102
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0015 0.0055 0.0632
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0021 0.0101 0.0101
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0115 0.0612
Plasmodium vivax SET domain protein, putative 0.0035 0.02 0.1725
Schistosoma mansoni patched 1 0.0051 0.0312 0.0857
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0186 0.0257
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.0033 0.0287
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0506 0.355 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0015 0.0055 0.0632
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0153 0.1035 0.4445
Echinococcus granulosus survival motor neuron protein 1 0.0262 0.1812 0.5093
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0101 0.0401
Echinococcus multilocularis cysteine protease atg4b 0.0119 0.0796 0.114
Trichomonas vaginalis endoplasmin, putative 0.0033 0.018 0.096
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0209 0.0209
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0203 0.0841
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0153 0.0573
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0153 0.0466
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.02 0.054
Schistosoma mansoni hypothetical protein 0.001 0.0017 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0045 0.0237
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0128 0.0863 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0158 0.0421
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0101 0.1168
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0033
Schistosoma mansoni endoplasmin 0.0045 0.0268 0.0733
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0009 0.0096
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0022 0.002
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0203 0.0841
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0033 0.007
Loa Loa (eye worm) hypothetical protein 0.037 0.2582 0.2582
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0103 0.0681 0.2675
Plasmodium falciparum cysteine protease ATG4, putative 0.0046 0.0279 0.2409
Schistosoma mansoni hypothetical protein 0.0049 0.0299 0.082
Schistosoma mansoni ap endonuclease 0.0021 0.0101 0.0261
Loa Loa (eye worm) hypothetical protein 0.0049 0.0296 0.0296
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0119 0.0796 0.3413
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0046 0.0279 0.2409
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0161 0.0606
Brugia malayi Cytochrome P450 family protein 0.0037 0.0209 0.0639
Trypanosoma cruzi phospholipase A1, putative 0.0333 0.2317 1
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0033 0.0107
Schistosoma mansoni DNA helicase recq1 0.001 0.0022 0.0038
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0046 0.0279 0.1173
Brugia malayi jmjC domain containing protein 0.0009 0.0016 0.0049
Loa Loa (eye worm) acetyltransferase 0.0156 0.1056 0.1056
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0009 0.0096
Loa Loa (eye worm) hypothetical protein 0.0035 0.02 0.02
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0222 0.0924
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0126 0.0171
Trypanosoma brucei heat shock protein, putative 0.0045 0.0268 0.1124
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0315 0.2714
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0134 0.0901 0.3864
Loa Loa (eye worm) hypothetical protein 0.0021 0.0101 0.0101
Schistosoma mansoni hypothetical protein 0.0105 0.0699 0.195
Echinococcus granulosus GPCR family 2 0.0049 0.0296 0.0812
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0009 0.0073
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0009 0.0096
Giardia lamblia DNA repair protein RAD52 0.0362 0.2522 1
Leishmania major sterol 24-c-methyltransferase, putative 0.0213 0.1464 0.6305
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0015 0.0055 0.1926
Echinococcus granulosus TRP transient receptor potential channel 0.0044 0.0259 0.0707
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0045 0.0237
Onchocerca volvulus 0.0008 0.0009 0.0009
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0033 0.0036
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0063 0.0154
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0055 0.0055
Schistosoma mansoni survival motor neuron protein 0.0053 0.0329 0.0904
Schistosoma mansoni cytochrome P450 0.0015 0.0055 0.013
Brugia malayi cytochrome P450 0.0015 0.0055 0.0167
Leishmania major heat shock protein, putative 0.003 0.0161 0.066
Onchocerca volvulus 0.0008 0.0009 0.0009
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0492 0.1366
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0045 0.0237
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0239 0.0652
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0126 0.0672
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0115 0.0612
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0795 0.3129
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0153 0.1035 0.4445
Echinococcus multilocularis protein patched 0.0051 0.0312 0.0439
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0119 0.0796 0.424
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0258 0.0704
Echinococcus granulosus endoplasmin 0.0042 0.0248 0.0678
Loa Loa (eye worm) hypothetical protein 0.004 0.0231 0.0231
Echinococcus multilocularis heat shock protein 0.0045 0.0268 0.0376
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.0859 0.0859
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0033 0.0102
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0082 0.032
Brugia malayi hypothetical protein 0.0033 0.0185 0.0565
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.02 0.054
Loa Loa (eye worm) hypothetical protein 0.0062 0.0394 0.0394
Brugia malayi hypothetical protein 0.0012 0.0033 0.0102
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0186 0.1608
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.01 0.0132
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0268 0.1124
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0203 0.1078
Echinococcus granulosus JmjC domain containing protein 4 0.0009 0.0016 0.0021
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0226 0.0613
Brugia malayi jmjC domain containing protein 0.0039 0.0226 0.0689
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0268 0.1426
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0015 0.0055 0.1926
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0154 0.0211
Loa Loa (eye worm) TAR-binding protein 0.0128 0.0859 0.0859
Loa Loa (eye worm) endoplasmin 0.0045 0.0268 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0033 0.0176
Echinococcus granulosus geminin 0.0506 0.355 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0153 0.6001
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0268 0.1124
Leishmania major heat shock protein 83-1 0.0045 0.0268 0.1124
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.1046 0.3195
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0213 0.1464 0.6305
Schistosoma mansoni heat shock protein 0.0045 0.0268 0.0733
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.0222 0.0799
Trypanosoma brucei Sterol methyltransferase, putative 0.0213 0.1464 0.6305
Trypanosoma brucei phospholipase A1, putative 0.0333 0.2317 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.02 0.1725
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0045 0.0237
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0154 0.1329
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0296 0.0812
Onchocerca volvulus 0.0333 0.2317 0.2317
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0044 0.0152
Brugia malayi hypothetical protein 0.0012 0.0033 0.0102
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0795 0.2221
Entamoeba histolytica hypothetical protein 0.0023 0.0115 0.0424
Brugia malayi PHD-finger family protein 0.0013 0.0041 0.0126
Schistosoma mansoni phosphatidylserine receptor 0.0009 0.0016 0.0021
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0134 0.0714
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0033 0.0099
Loa Loa (eye worm) platelet-activating factor acetylhydrolase 0.0333 0.2317 0.2317
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0101 0.0401
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0186 0.0257
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.0268 0.1124
Echinococcus multilocularis JmjC domain containing protein 4 0.0009 0.0016 0.0011
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.01 0.0305
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0015 0.0055 0.1926
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0044 0.0259 0.0362
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0186 0.077
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0296 0.0416
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0069 0.0594
Echinococcus multilocularis geminin 0.0506 0.355 0.5124
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0158
Leishmania major GTP-binding protein, putative 0.0021 0.01 0.0396
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0046 0.0279 0.1173
Echinococcus multilocularis vesicular acetylcholine transporter 0.0467 0.3275 0.4726
Leishmania major heat shock protein 83-1 0.0045 0.0268 0.1124
Echinococcus granulosus peregrin 0.0033 0.0185 0.0497
Brugia malayi Pre-SET motif family protein 0.0035 0.02 0.061
Schistosoma mansoni hypothetical protein 0.0308 0.2142 0.6023
Onchocerca volvulus Alhambra homolog 0.0029 0.0158 0.0158
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0158 0.0421
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0009 0.0016 0.0033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0093 0.1072
Loa Loa (eye worm) hypothetical protein 0.0044 0.0259 0.0259
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0329 0.1004
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0186 0.2158
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.01 0.0311
Schistosoma mansoni vesicular acetylcholine transporter 0.0467 0.3275 0.9224
Trypanosoma brucei lanosterol synthase 0.0193 0.1324 0.5697
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0015 0.0055 0.0632
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.02 0.0277
Brugia malayi hypothetical protein 0.0262 0.1812 0.5534
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.0033 0.0287
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0009 0.0016 0.0033
Schistosoma mansoni hypothetical protein 0.0023 0.0113 0.0295
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0015 0.0055 0.1926
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0033
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0203 0.0772
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.0222 0.0603
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0022 0.019
Plasmodium falciparum importin beta, putative 0.0029 0.0154 0.1329
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0044 0.0152
Onchocerca volvulus Phospholipase A2 homolog 0.1412 1 1
Onchocerca volvulus 0.0134 0.0901 0.0901
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0015 0.0055 0.1926
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0009 0.0026
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0033 0.0287
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0268 0.1124
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0154 0.063
Leishmania major heat shock protein 83-1 0.0045 0.0268 0.1124
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0046 0.0279 0.1173
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0045 0.0237
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0015 0.0055 0.1926
Entamoeba histolytica hypothetical protein 0.0043 0.0258 0.0992
Leishmania major heat shock protein 83-1 0.0045 0.0268 0.1124
Plasmodium vivax heat shock protein 90, putative 0.003 0.0161 0.1388
Leishmania major heat shock protein 83-1 0.0045 0.0268 0.1124
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0111 0.0739 0.3164
Loa Loa (eye worm) hypothetical protein 0.0051 0.0312 0.0312
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0018 0.0028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0045 0.0237
Leishmania major cytochrome p450-like protein 0.0015 0.0055 0.02
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0186 0.0502
Plasmodium falciparum endoplasmin, putative 0.0033 0.018 0.1557
Brugia malayi isocitrate dehydrogenase 0.0033 0.0186 0.0569
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0153 0.0466
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0274 0.0751
Echinococcus granulosus heat shock protein 90 0.0045 0.0268 0.0733
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0009 0.0026
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0015 0.0055 0.02
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0017 0.0036
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0312 0.0312
Brugia malayi RNA, U transporter 1 0.0082 0.0533 0.1627
Brugia malayi hypothetical protein 0.0043 0.0258 0.0788
Trypanosoma cruzi Emopamil binding protein, putative 0.0134 0.0901 0.3864
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0015 0.0055 0.1926
Schistosoma mansoni hypothetical protein 0.0049 0.0296 0.0812
Entamoeba histolytica peptidase, C54 family 0.0046 0.0279 0.1077
Schistosoma mansoni endoplasmin 0.0045 0.0268 0.0733
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0015 0.0055 0.0632
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0296 0.0416
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0043 0.0369
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0022 0.002
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0222 0.0924
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0015 0.0055 0.0632
Echinococcus multilocularis lysine specific demethylase 6a 0.0009 0.0016 0.0011
Echinococcus granulosus Peptidase C54 0.0119 0.0796 0.2225
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0009 0.0044
Entamoeba histolytica hypothetical protein 0.0043 0.0258 0.0992
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0859 0.2402
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0101 0.0537
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0226 0.0226
Echinococcus multilocularis expressed conserved protein 0.0112 0.0744 0.1064
Loa Loa (eye worm) hypothetical protein 0.0029 0.0154 0.0154
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0009 0.0026
Trypanosoma brucei heat shock protein, putative 0.0045 0.0268 0.1124
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0017 0.0036
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0153 0.0624
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0315 0.1326
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.0501 0.139
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0119 0.0796 0.2225
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0153 0.6001
Loa Loa (eye worm) jmjC domain-containing protein 0.0009 0.0016 0.0016
Schistosoma mansoni heat shock protein 0.003 0.0161 0.043
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0158 0.1359
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0274 0.2367
Schistosoma mansoni hypothetical protein 0.0029 0.0158 0.0421
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1158 0.3247
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0101 0.3859
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.01 0.0861
Mycobacterium leprae putative cytochrome p450 0.0015 0.0055 0.1926
Onchocerca volvulus 0.0333 0.2317 0.2317
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0016
Entamoeba histolytica peptidase, C54 family 0.0046 0.0279 0.1077
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0101 0.3152
Schistosoma mansoni cpg binding protein 0.006 0.0373 0.1028
Echinococcus granulosus transient receptor potential gamma protein 0.0117 0.0783 0.2187
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0089 0.0227
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0467 0.3275 0.3275
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0055 0.02
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0186 0.1608
Trichomonas vaginalis set domain proteins, putative 0.0271 0.1878 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0186 0.0257
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0115 0.0462
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0009 0.0073
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0101 0.3152
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0859 0.2402
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0153 0.1765
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0015 0.0055 0.0632
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.2142 0.2142
Plasmodium falciparum heat shock protein 90 0.0045 0.0268 0.2313
Echinococcus multilocularis phd:f box containing protein 0.0009 0.0016 0.0011
Schistosoma mansoni DNA ligase IV 0.0012 0.0033 0.007
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.0501 0.0712
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0153 0.0466
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0009 0.0073
Leishmania major heat shock protein 83-1 0.0045 0.0268 0.1124
Echinococcus granulosus heat shock protein 0.0045 0.0268 0.0733
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0045 0.0237
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0089 0.0227
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0017 0.0146
Schistosoma mansoni hypothetical protein 0.0049 0.0296 0.0812
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.0268 0.1124
Trypanosoma brucei heat shock protein, putative 0.0045 0.0268 0.1124
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0134 0.0901 0.3864
Schistosoma mansoni protein phosphatase 2C 0.0009 0.0016 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0045 0.0237
Schistosoma mansoni transient receptor potential channel 0.0078 0.0501 0.139
Brugia malayi vesicular acetylcholine transporter unc-17 0.0467 0.3275 1
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0101 0.0537
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0015 0.0055 0.1926
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0033
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0153 0.6001
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0009 0.0026
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0022 0.019
Entamoeba histolytica Ran family GTPase 0.0021 0.01 0.0363
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0119 0.0796 0.424
Echinococcus granulosus vesicular acetylcholine transporter 0.0467 0.3275 0.9224
Entamoeba histolytica peptidase, C54 family 0.0046 0.0279 0.1077
Brugia malayi topoisomerase 0.0012 0.0033 0.0102
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0033 0.0287
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0016
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0022 0.0067
Plasmodium falciparum heat shock protein 90, putative 0.017 0.1159 1
Brugia malayi CHE-14 protein 0.0051 0.0312 0.0952
Loa Loa (eye worm) heat shock protein 75 0.003 0.0161 0.0161
Onchocerca volvulus 0.0271 0.1878 0.1878
Trichomonas vaginalis helicase, putative 0.0013 0.0045 0.0237
Entamoeba histolytica hypothetical protein 0.0103 0.0681 0.2675
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0033 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0045 0.0237
Loa Loa (eye worm) hypothetical protein 0.0154 0.1046 0.1046
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0153 0.0573
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0055 0.02
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0315 0.2714
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.0501 0.139
Schistosoma mansoni ran 0.0021 0.01 0.0258
Trichomonas vaginalis heat shock protein, putative 0.0033 0.018 0.096
Toxoplasma gondii heat shock protein HSP90 0.0045 0.0268 0.2313
Schistosoma mansoni hypothetical protein 0.0049 0.0299 0.082
Entamoeba histolytica hypothetical protein 0.0043 0.0258 0.0992
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1158 0.1664
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0315 0.1326
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0022 0.019
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0186 0.077
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0093 0.1072
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0186 0.0186
Echinococcus multilocularis peregrin 0.0033 0.0185 0.0255
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0045 0.0237
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0008 0.0009 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0859 0.2402
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0296 0.0812
Echinococcus granulosus lysine specific demethylase 6a 0.0009 0.0016 0.0021
Brugia malayi Phospholipase A2 family protein 0.037 0.2582 0.7884
Onchocerca volvulus Phospholipase A2 homolog 0.037 0.2582 0.2582
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0633 0.0903
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0101 0.0871
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0203 0.0841
Trypanosoma cruzi lanosterol synthase, putative 0.0193 0.1324 0.5697
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0119 0.0796 0.424
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0268 0.1124
Trypanosoma cruzi heat shock protein, putative 0.003 0.0161 0.066
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.0248 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0015 0.0055 0.1926
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0201 0.0279
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0258 0.0361
Brugia malayi acetyltransferase, GNAT family protein 0.0156 0.1056 0.3225
Schistosoma mansoni hypothetical protein 0.0049 0.0296 0.0812
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0126 0.0672
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0101 0.117
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0859 0.2402
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0045 0.0237
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0022 0.0038
Leishmania major hypothetical protein, conserved 0.0009 0.0016 0.0033
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0009 0.0009
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0015 0.0055 0.0632
Schistosoma mansoni ap endonuclease 0.0021 0.0101 0.0261
Echinococcus granulosus jumonji domain containing 1A 0.0009 0.0016 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0033 0.0176
Leishmania major heat shock protein 83-1 0.0045 0.0268 0.1124
Brugia malayi jmjC domain containing protein 0.0009 0.0016 0.0049
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0015 0.0055 0.1926
Trypanosoma cruzi phospholipase A1, putative 0.0333 0.2317 1
Giardia lamblia Grp94/Hsp90 0.0042 0.0248 0.0906
Brugia malayi CXXC zinc finger family protein 0.006 0.0373 0.1138
Loa Loa (eye worm) inositol-1 0.0036 0.0203 0.0203
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.01 0.0396
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0153 0.0624
Echinococcus multilocularis snurportin 1 0.0308 0.2142 0.3086
Loa Loa (eye worm) hypothetical protein 0.0105 0.0699 0.0699
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0213 0.1464 0.6305
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0015 0.0055 0.1926
Plasmodium vivax importin-beta 2, putative 0.0029 0.0154 0.1329
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0315 0.2714
Schistosoma mansoni hypothetical protein 0.0049 0.0299 0.082
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0176 0.6984
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0101 0.0401
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0046 0.0279 0.1173
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0101 0.0309
Trypanosoma brucei Emopamil binding protein, putative 0.0134 0.0901 0.3864
Loa Loa (eye worm) oxidoreductase 0.0008 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0439 0.3075 0.8658
Leishmania major cytochrome p450-like protein 0.0015 0.0055 0.02
Loa Loa (eye worm) hypothetical protein 0.0262 0.1812 0.1812
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0153 0.6001
Echinococcus granulosus expressed conserved protein 0.0112 0.0744 0.2076
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0312 0.0857
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0101 0.0368
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0128 0.0857 0.2396
Entamoeba histolytica hypothetical protein 0.0012 0.0033 0.0099
Loa Loa (eye worm) hypothetical protein 0.0021 0.0101 0.0101
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0101 0.0871
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0063 0.0154
Brugia malayi PHD-finger family protein 0.0029 0.0158 0.0481
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0015 0.0055 0.1926
Leishmania major hypothetical protein, conserved 0.0134 0.0901 0.3864
Onchocerca volvulus 0.0008 0.0009 0.0009
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0015 0.0055 0.0632
Brugia malayi Inositol-1 0.0036 0.0203 0.0619
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0015 0.0055 0.1926
Echinococcus granulosus histone acetyltransferase KAT2B 0.0151 0.1025 0.2871
Schistosoma mansoni autophagin-1 (C54 family) 0.0119 0.0796 0.2225
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0315 0.1326
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0045 0.0237
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.02 0.0277
Brugia malayi jmjC domain containing protein 0.0096 0.0633 0.1932
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0274 0.146
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0161 0.0161
Loa Loa (eye worm) RNA binding protein 0.0128 0.0859 0.0859
Echinococcus granulosus nibrin 0.0012 0.0033 0.007
Loa Loa (eye worm) hypothetical protein 0.0117 0.0783 0.0783
Echinococcus multilocularis GPCR, family 2 0.0049 0.0296 0.0416
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0055 0.013
Schistosoma mansoni phd/f-box containing protein 0.0009 0.0016 0.0021
Brugia malayi Cytochrome P450 family protein 0.0015 0.0055 0.0167
Loa Loa (eye worm) heat shock protein 90 0.0045 0.0268 0.0268
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.02 0.054
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0156 0.1056 0.1516
Leishmania major heat shock protein 83-1 0.0045 0.0268 0.1124
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0131 0.0346
Loa Loa (eye worm) hypothetical protein 0.0119 0.0795 0.0795
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0 0.00000000016109
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0033 0.0107
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0247 0.0901
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0795 0.2428
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0009 0.0016 0.0139
Loa Loa (eye worm) RecQ helicase 0.0025 0.0126 0.0126
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.1046 0.1046
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0158 0.1359
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.038 0.038
Brugia malayi Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein 0.0333 0.2317 0.7075
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0808 0.2258
Loa Loa (eye worm) hypothetical protein 0.0119 0.0796 0.0796
Leishmania major cytochrome p450-like protein 0.0015 0.0055 0.02
Toxoplasma gondii exonuclease III APE 0.0021 0.0101 0.0872
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0268 0.1033
Leishmania major sterol 24-c-methyltransferase, putative 0.0213 0.1464 0.6305
Echinococcus granulosus heat shock protein 90 0.0038 0.0222 0.0603
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0119 0.0796 0.2225
Echinococcus multilocularis tar DNA binding protein 0.0128 0.0859 0.1231
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0009 0.0044
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0009 0.0096
Schistosoma mansoni topbp1 0.0012 0.0033 0.007
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0033 0.0176
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0186 0.0257
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0044 0.0152
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0093 0.1072
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0134 0.0901 0.3864
Echinococcus multilocularis endoplasmin 0.0042 0.0248 0.0347
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0055 0.02
Brugia malayi heat shock protein 90 0.0045 0.0268 0.0819
Loa Loa (eye worm) hypothetical protein 0.0126 0.0843 0.0843
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0012 0.0033 0.1033
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0155 0.0474
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0101 0.0316
Brugia malayi hypothetical protein 0.0051 0.0315 0.0961
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0105 0.0904
Schistosoma mansoni hypothetical protein 0.0506 0.355 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0113 0.0295
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0161 0.1388
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0268 0.0984
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0033 0.0176
Leishmania major heat shock protein 83-1 0.0045 0.0268 0.1124
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0186 0.0257
Brugia malayi S-adenosyl-methionine cycloartenol-C24-methyltransferase 0.0104 0.0687 0.2098
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0268 0.1124
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.02 0.054
Schistosoma mansoni transient receptor potential channel 0.0117 0.0783 0.2187
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0015 0.0055 0.0632
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0009 0.0096
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0161 0.022
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0186 0.077
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.01 0.0258
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0101 0.0261
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0033 0.0176
Schistosoma mansoni heat shock protein 0.0045 0.0268 0.0733
Loa Loa (eye worm) hypothetical protein 0.005 0.0307 0.0307
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0013 0.0043 0.0369
Loa Loa (eye worm) hypothetical protein 0.0021 0.0101 0.0101
Loa Loa (eye worm) jmjC domain-containing protein 0.0009 0.0016 0.0016
Onchocerca volvulus 0.0012 0.0035 0.0035
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0154 0.063
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0033 0.0176
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0312 0.0857
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0226 0.0613
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0296 0.0904
Loa Loa (eye worm) hypothetical protein 0.0029 0.0153 0.0153
Echinococcus granulosus cysteine protease atg4b 0.0119 0.0796 0.2225
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0015 0.0055 0.1926
Schistosoma mansoni importin beta-1 0.0029 0.0154 0.0411
Mycobacterium ulcerans hypothetical protein 0.0029 0.0153 0.6001

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 4.216 uM PUBCHEM_BIOASSAY: Confirmation dose response assay for compounds that inhibit transient receptor potential cation channel C4 (TRPC4). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2247, AID2256] ChEMBL. No reference
Potency (functional) 2.2387 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.8048 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 6.5104 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 7.5686 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 8.1961 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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