Detailed information for compound 1302861

Basic information

Technical information
  • TDR Targets ID: 1302861
  • Name: 8-[1-(4-dimethylaminophenyl)-3-morpholin-4-yl propyl]-5,7-dimethoxy-4-(4-methoxyphenyl)chro man-2-one
  • MW: 560.68 | Formula: C33H40N2O6
  • H donors: 0 H acceptors: 1 LogP: 4.87 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)C1CC(=O)Oc2c1c(OC)cc(c2C(c1ccc(cc1)N(C)C)CCN1CCOCC1)OC
  • InChi: 1S/C33H40N2O6/c1-34(2)24-10-6-22(7-11-24)26(14-15-35-16-18-40-19-17-35)31-28(38-4)21-29(39-5)32-27(20-30(36)41-33(31)32)23-8-12-25(37-3)13-9-23/h6-13,21,26-27H,14-20H2,1-5H3
  • InChiKey: WDNBAIVCBMDRDB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 8-[1-(4-dimethylaminophenyl)-3-morpholino-propyl]-5,7-dimethoxy-4-(4-methoxyphenyl)chroman-2-one
  • 8-[1-(4-dimethylaminophenyl)-3-morpholinopropyl]-5,7-dimethoxy-4-(4-methoxyphenyl)-2-chromanone
  • 8-[1-(4-dimethylaminophenyl)-3-morpholin-4-yl-propyl]-5,7-dimethoxy-4-(4-methoxyphenyl)chroman-2-one
  • MLS000879437
  • SMR000465610

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.0005 0.003
Schistosoma mansoni synaptojanin 0.002 0.0005 0.0047
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0273 0.0326 0.8274
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0024 0.2097
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0024 0.001 0.001
Brugia malayi beta-lactamase family protein 0.0035 0.0024 0.0574
Brugia malayi hypothetical protein 0.0122 0.0134 0.337
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.002 0.0005 0.0188
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0069 0.0064
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0078 0.0079 0.0763
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0006 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0006 0.0099
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0006 0.0017
Echinococcus granulosus Niemann Pick C1 protein 0.0427 0.0521 0.5007
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0078 0.0079 0.7453
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0047
Loa Loa (eye worm) bromodomain containing protein 0.0029 0.0016 0.0173
Loa Loa (eye worm) MBCTL1 0.0105 0.0113 0.1403
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0006 0.0001
Brugia malayi Patched family protein 0.0018 0.0003 0.0015
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0006 0.0111
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.003
Trichomonas vaginalis glutaminase, putative 0.0267 0.0317 0.8449
Onchocerca volvulus 0.002 0.0005 0.005
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0009 0.0015
Loa Loa (eye worm) CXXC zinc finger family protein 0.0117 0.0128 0.1593
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0024 0.0185
Echinococcus granulosus traf and tnf receptor associated protein 0.002 0.0005 0.0004
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0005 0.0188
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0069 0.1924
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0006 0.0001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0005 0.0188
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0273 0.0326 0.3145
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0039 0.0941
Brugia malayi steroid hormone receptor 0.0021 0.0006 0.0111
Echinococcus granulosus chromobox protein 1 0.0084 0.0086 0.0792
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0006 0.0008
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0069 0.0064
Brugia malayi Patched protein homolog 1 0.0018 0.0003 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0039 0.0028 0.0275
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0006 0.0111
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0024 0.0022
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.0005 0.0002
Toxoplasma gondii t-complex protein beta subunit 0.0025 0.0012 0.0009
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0003 0.0001
Onchocerca volvulus Huntingtin homolog 0.0122 0.0134 0.336
Brugia malayi acetyltransferase, GNAT family protein 0.0311 0.0374 0.9506
Leishmania major hypothetical protein, conserved 0.0035 0.0024 0.2097
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0046 0.0042
Brugia malayi Patched family protein 0.0018 0.0003 0.0015
Schistosoma mansoni hypothetical protein 0.0289 0.0346 0.3337
Brugia malayi protein C24B5.3 0.0018 0.0003 0.0015
Loa Loa (eye worm) hypothetical protein 0.0105 0.0113 0.1403
Loa Loa (eye worm) hypothetical protein 0.0071 0.0069 0.0843
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0005 0.0076
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0024 0.0065
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0005 0.0076
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0006 0.0111
Brugia malayi Patched family protein 0.0018 0.0003 0.0015
Leishmania major hypothetical protein, conserved 0.002 0.0005 0.0188
Brugia malayi Bromodomain containing protein 0.0105 0.0112 0.2822
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0069 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0006 0.0111
Loa Loa (eye worm) hypothetical protein 0.0024 0.001 0.0094
Brugia malayi Myosin head containing protein 0.0018 0.0003 0.0015
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0003 0.0024
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0042 0.036
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0006 0.0001
Schistosoma mansoni ran 0.0044 0.0035 0.0342
Entamoeba histolytica acetyltransferase, GNAT family 0.0083 0.0085 0.237
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0055 0.5145
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0009 0.0088
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0013 0.0235
Loa Loa (eye worm) hypothetical protein 0.0035 0.0024 0.0278
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.0005 0.0002
Echinococcus multilocularis zinc finger protein 0.0038 0.0028 0.0076
Plasmodium falciparum T-complex protein 1 subunit beta 0.0025 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0049 0.0042 0.0504
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0043 0.1047
Schistosoma mansoni cpg binding protein 0.0126 0.0139 0.1346
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0006 0.0099
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0009 0.0083
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.1036 1
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.002 0.0005 0.0137
Loa Loa (eye worm) hypothetical protein 0.0035 0.0024 0.0278
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.002 0.0005 0.0011
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0042 0.0123
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.002 0.0005 0.0188
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.0375 0.9528
Loa Loa (eye worm) hypothetical protein 0.0059 0.0055 0.0661
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.001 0.0678
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0009 0.06
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0006 0.0276
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0043 0.0088
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0069 0.1711
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0099 0.0105 0.0101
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0105 0.0113 0.1053
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0006 0.0017
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0035 0.0099
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0055 0.0486
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0006 0.0008
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0009 0.0015
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0093 0.0097 0.0935
Echinococcus multilocularis protein dispatched 1 0.0146 0.0165 0.0531
Brugia malayi Patched family protein 0.0018 0.0003 0.0015
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.001 0.0007
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0013 0.0293
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0005 0.0137
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0008 0.0081
Trypanosoma brucei RNA editing exonuclease 2 0.002 0.0005 0.0188
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0005 0.0149
Loa Loa (eye worm) hypothetical protein 0.0122 0.0134 0.1667
Echinococcus multilocularis SAM and MBT domain containing protein 0.0093 0.0097 0.0305
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0024 0.0537
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0006 0.0004
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0005 0.00000034566
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0078 0.0079 0.0077
Trypanosoma brucei unspecified product 0.0023 0.0009 0.06
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.064 0.079 1
Plasmodium falciparum importin beta, putative 0.006 0.0055 0.0055
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0009 0.0124
Brugia malayi hypothetical protein 0.0018 0.0003 0.0015
Onchocerca volvulus 0.0021 0.0006 0.0084
Brugia malayi Patched family protein 0.0018 0.0003 0.0015
Echinococcus granulosus SAM and MBT domain containing protein 0.0093 0.0097 0.0895
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0024 0.0193
Brugia malayi Patched family protein 0.0018 0.0003 0.0015
Schistosoma mansoni jumonji/arid domain-containing protein 0.0052 0.0045 0.0434
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0078 0.0079 0.197
Echinococcus granulosus histone acetyltransferase KAT2B 0.0094 0.0098 0.0908
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0099 0.0105 0.0105
Schistosoma mansoni survival motor neuron protein 0.005 0.0043 0.0415
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.001 0.0203
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0071 0.0069 0.0064
Schistosoma mansoni zinc finger protein 0.0038 0.0028 0.0266
Loa Loa (eye worm) TAR-binding protein 0.0142 0.016 0.1993
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0009 0.06
Brugia malayi CHD4 protein 0.0023 0.0008 0.0165
Brugia malayi F/Y-rich N-terminus family protein 0.0051 0.0044 0.1077
Onchocerca volvulus 0.0035 0.0024 0.0559
Onchocerca volvulus 0.0326 0.0393 1
Schistosoma mansoni carbon catabolite repressor protein 0.002 0.0005 0.0047
Treponema pallidum exodeoxyribonuclease (exoA) 0.0099 0.0105 0.0101
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0006 0.0017
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0006 0.0162
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0099 0.0105 0.2932
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0006 0.0008
Schistosoma mansoni hypothetical protein 0.0035 0.0024 0.0234
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0023 0.0008 0.0013
Trichomonas vaginalis ap endonuclease, putative 0.0099 0.0105 0.2715
Echinococcus multilocularis bloom syndrome protein 0.0024 0.001 0.0018
Echinococcus multilocularis histone acetyltransferase MYST2 0.0105 0.0113 0.0359
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0058 0.5399
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0024 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0009 0.06
Brugia malayi Patched related family protein 10 0.0018 0.0003 0.0015
Echinococcus granulosus tumor protein p63 0.0338 0.0407 0.3908
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0006 0.0111
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0005 0.0137
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.002 0.0005 0.0011
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0005 0.0076
Schistosoma mansoni sex comb on midleg homolog 0.0093 0.0097 0.0935
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0239 0.633
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0005 0.0149
Trichomonas vaginalis esterase, putative 0.0035 0.0024 0.0537
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0006 0.0035
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0044 0.1058
Mycobacterium ulcerans lipase LipD 0.0035 0.0024 0.002
Echinococcus multilocularis protein patched 0.0128 0.0142 0.0455
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0006 0.0041
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0006 0.0001
Plasmodium falciparum DNase I-like protein, putative 0.002 0.0005 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0006 0.0047
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0024 0.002
Echinococcus multilocularis traf and tnf receptor associated protein 0.002 0.0005 0.0001
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.0005 0.0066
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0006 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0239 0.633
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0006 0.0111
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0005 0.0137
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0031 0.0706
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.0005 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0047
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0039 0.0941
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0031 0.0706
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0031 0.0706
Loa Loa (eye worm) hypothetical protein 0.0053 0.0046 0.0556
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0006 0.0003
Echinococcus granulosus bloom syndrome protein 0.0024 0.001 0.0052
Plasmodium vivax hypothetical protein, conserved 0.002 0.0005 0.0002
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0078 0.0079 0.0077
Brugia malayi Niemann-Pick C1 protein precursor 0.0299 0.0358 0.9106
Loa Loa (eye worm) hypothetical protein 0.0053 0.0046 0.0556
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0024 0.0537
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0031 0.0706
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0039 0.0028 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0006 0.0111
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0058 0.0056
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0081 0.2249
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0058 0.0054
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.002 0.0005 0.0005
Brugia malayi Importin beta-1 subunit 0.006 0.0055 0.1368
Loa Loa (eye worm) hypothetical protein 0.0031 0.0019 0.0204
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.029 0.0945
Echinococcus multilocularis sterol regulatory element binding protein 0.0128 0.0142 0.0455
Schistosoma mansoni synaptojanin 0.002 0.0005 0.0047
Plasmodium falciparum histone acetyltransferase GCN5 0.0083 0.0085 0.0085
Loa Loa (eye worm) RNA binding protein 0.0142 0.016 0.1993
Loa Loa (eye worm) hypothetical protein 0.0157 0.0179 0.2236
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0375 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.001 0.0007
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0006 0.0276
Brugia malayi glutaminase DH11.1 0.0267 0.0317 0.806
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0006 0.0276
Plasmodium vivax SET domain protein, putative 0.0039 0.0028 0.0026
Schistosoma mansoni patched 1 0.0128 0.0142 0.1372
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0375 1
Trichomonas vaginalis set domain proteins, putative 0.0289 0.0345 0.9204
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0069 0.0064
Echinococcus granulosus fetal alzheimer antigen falz 0.0034 0.0023 0.0175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0006 0.0047
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0006 0.0008
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0024 0.0537
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0021
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0103 0.2578
Brugia malayi mbt repeat family protein 0.0093 0.0097 0.2424
Schistosoma mansoni jumonji/arid domain-containing protein 0.0052 0.0045 0.0434
Trichomonas vaginalis ap endonuclease, putative 0.0099 0.0105 0.2715
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0078 0.0079 0.2013
Loa Loa (eye worm) hypothetical protein 0.0035 0.0024 0.0278
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0006 0.0061
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0034 0.0023 0.0218
Brugia malayi Pre-SET motif family protein 0.0039 0.0028 0.0679
Loa Loa (eye worm) hypothetical protein 0.0035 0.0024 0.0278
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0009 0.0015
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0042 0.0408
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0078 0.0079 0.0247
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0024 0.0048
Mycobacterium tuberculosis Conserved protein 0.0035 0.0024 0.0048
Brugia malayi Patched family protein 0.0018 0.0003 0.0015
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0069 0.0064
Giardia lamblia Inositol 5-phosphatase 4 0.002 0.0005 0.0039
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0006 0.0276
Schistosoma mansoni zinc finger protein 0.0018 0.0003 0.0029
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0009 0.0088
Brugia malayi Patched related family protein 12 0.0018 0.0003 0.0015
Brugia malayi Patched family protein 0.0018 0.0003 0.0015
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0035 0.3181
Loa Loa (eye worm) hypothetical protein 0.006 0.0056 0.068
Echinococcus granulosus neutral sphingomyelinase 0.002 0.0005 0.0004
Entamoeba histolytica hypothetical protein 0.002 0.0005 0.0126
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0006 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0013 0.0235
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0006 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0239 0.633
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0006 0.0008
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0009 0.06
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0078 0.0079 0.7453
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0086 0.0089 0.0819
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0078 0.0079 0.0972
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0044 0.1063
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0024 0.0191
Loa Loa (eye worm) hypothetical protein 0.0097 0.0103 0.1274
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0034 0.0023 0.006
Toxoplasma gondii exonuclease III APE 0.0099 0.0105 0.0103
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0005 0.0008
Echinococcus granulosus geminin 0.0536 0.0659 0.635
Echinococcus granulosus peregrin 0.0046 0.0037 0.0319
Loa Loa (eye worm) hypothetical protein 0.0122 0.0134 0.1667
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0273 0.0326 0.3145
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0024 0.0048
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0078 0.0079 0.0079
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.0006 0.0001
Brugia malayi hypothetical protein 0.0018 0.0003 0.0015
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.0005 0.0126
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0024 0.0048
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0005 0.0076
Trypanosoma cruzi mitochondrial protein 99, putative 0.002 0.0005 0.0188
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0019 0.0425
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0022 0.0469
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0081 0.7604
Loa Loa (eye worm) hypothetical protein 0.0023 0.0009 0.0083
Loa Loa (eye worm) hypothetical protein 0.0037 0.0026 0.0303
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0006 0.0017
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0006 0.0061
Echinococcus granulosus lamin 0.0027 0.0013 0.0086
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0099 0.0105 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.0005 0.003
Onchocerca volvulus 0.002 0.0005 0.0061
Trichomonas vaginalis chaperonin, putative 0.0025 0.0012 0.0192
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0035 0.3077
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0035 0.0035
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0024 0.0235
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0582 0.0718 0.693
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0013 0.0235
Plasmodium falciparum phd finger protein, putative 0.0035 0.0024 0.0024
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0103 0.2578
Loa Loa (eye worm) hypothetical protein 0.0098 0.0103 0.1278
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0046 0.0555
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.0005 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0006 0.0099
Loa Loa (eye worm) CHromoDomain protein family member 0.0023 0.0008 0.0075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0006 0.0006
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0042 0.0033 0.0316
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0006 0.0096
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0031 0.0706
Leishmania major T-complex protein 1, beta subunit, putative 0.0025 0.0012 0.0846
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0099 0.0105 1
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.0239 0.6049
Onchocerca volvulus 0.0093 0.0097 0.2413
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0024 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0013 0.0235
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.002 0.0005 0.0011
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0006 0.0099
Leishmania major RNA-editing complex protein MP100, putative 0.002 0.0005 0.0188
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0078 0.0079 0.197
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0006 0.0096
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0019 0.0136
Schistosoma mansoni hypothetical protein 0.0124 0.0136 0.1315
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0006 0.0003
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0078 0.0079 0.0723
Echinococcus granulosus polycomb protein SCMH1 0.0093 0.0097 0.0895
Schistosoma mansoni DNA polymerase eta 0.0023 0.0009 0.0088
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0006 0.0055
Echinococcus granulosus cpg binding protein 0.0126 0.0139 0.1308
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0069 0.646
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0013 0.0138
Echinococcus multilocularis muscleblind protein 0.0155 0.0176 0.0566
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0038 0.0027 0.022
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.0005 0.0002
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0009 0.0015
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0006 0.0061
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0009 0.06
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.001 0.0146
Brugia malayi Heterochromatin protein 1 0.0084 0.0086 0.2153
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0009 0.06
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0105 0.0113 0.0359
Echinococcus granulosus chromobox protein 1 0.0084 0.0086 0.0792
Loa Loa (eye worm) hypothetical protein 0.0299 0.0358 0.4517
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0005 0.0000028226
Schistosoma mansoni hypothetical protein 0.0025 0.0011 0.0108
Echinococcus multilocularis cpg binding protein 0.0126 0.0139 0.0446
Echinococcus granulosus Protein patched homolog 1 0.0128 0.0142 0.1334
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0094 0.0098 0.2528
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0025
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.004 0.0031 0.0706
Brugia malayi Patched family protein 0.0018 0.0003 0.0015
Trichomonas vaginalis Phospholipase C precursor, putative 0.002 0.0005 0.0011
Schistosoma mansoni hypothetical protein 0.0124 0.0136 0.1315
Echinococcus granulosus importin subunit beta 1 0.006 0.0055 0.0494
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0013 0.0138
Brugia malayi Patched family protein 0.0018 0.0003 0.0015
Loa Loa (eye worm) hypothetical protein 0.0245 0.029 0.3653
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0012 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0006 0.0111
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0043 0.0088
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0006 0.0001
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.002 0.0005 0.0137
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0311 0.0374 0.3611
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0069 0.0064
Giardia lamblia hypothetical protein 0.002 0.0005 0.0039
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0006 0.0096
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0024 0.0275
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0053 0.0046 0.0556
Trichomonas vaginalis bromodomain-containing protein, putative 0.0094 0.0098 0.2528
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0006 0.0008
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0064 0.1582
Echinococcus granulosus muscleblind protein 0.0155 0.0176 0.1661
Brugia malayi PHD-finger family protein 0.002 0.0006 0.0092
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0025
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0005 0.0188
Echinococcus granulosus replication factor c subunit 1 0.002 0.0005 0.0000010136
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0013 0.0235
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0009 0.0183
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0041 0.3738
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0019 0.0136
Entamoeba histolytica sphingomyelinase C precursor, putative 0.002 0.0005 0.0137
Entamoeba histolytica hypothetical protein 0.0289 0.0346 0.9645
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0093 0.0097 0.2413
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.7907 1 1
Brugia malayi hypothetical protein 0.0326 0.0393 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0009 0.06
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0006 0.0013
Onchocerca volvulus 0.0071 0.0069 0.1699
Echinococcus multilocularis importin subunit beta 1 0.006 0.0055 0.0169
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0081 0.0991
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0375 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0071 0.0069 0.0064
Schistosoma mansoni hypothetical protein 0.0018 0.0003 0.0029
Echinococcus multilocularis Niemann Pick C1 protein 0.0299 0.0358 0.117
Mycobacterium ulcerans hypothetical protein 0.0071 0.0069 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0253 0.6707
Plasmodium vivax exodeoxyribonuclease III, putative 0.002 0.0005 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0009 0.06
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0038 0.0027 0.0075
Schistosoma mansoni DNA ligase IV 0.002 0.0005 0.0044
Brugia malayi Cytochrome P450 family protein 0.0053 0.0046 0.1133
Schistosoma mansoni chromobox protein 0.0084 0.0086 0.0832
Onchocerca volvulus 0.0049 0.0042 0.1015
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.001 0.0678
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0022 0.0469
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.001 0.0146
Mycobacterium tuberculosis Conserved protein 0.0035 0.0024 0.0048
Leishmania major hypothetical protein, conserved 0.002 0.0005 0.0188
Trichomonas vaginalis helicase, putative 0.0027 0.0013 0.0235
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0025 0.0012 0.0009
Brugia malayi Patched family protein 0.0018 0.0003 0.0015
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0024 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0239 0.633
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0024 0.2097
Loa Loa (eye worm) histone methyltransferase 0.0038 0.0027 0.0313
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0024 0.0537
Echinococcus granulosus lysine specific demethylase 5A 0.0052 0.0045 0.0392
Mycobacterium tuberculosis Conserved protein 0.0035 0.0024 0.0048
Echinococcus multilocularis deoxyribonuclease 1 2 0.002 0.0005 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0006 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0239 0.633
Loa Loa (eye worm) mbt repeat family protein 0.0093 0.0097 0.1197
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0035 0.0033
Brugia malayi hypothetical protein 0.002 0.0005 0.0066
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0024 0.0022
Loa Loa (eye worm) jmjC domain-containing protein 0.0052 0.0045 0.0539
Brugia malayi beta-lactamase family protein 0.0035 0.0024 0.0574
Echinococcus granulosus microtubule associated protein 2 0.0833 0.1036 1
Schistosoma mansoni topbp1 0.002 0.0005 0.0044
Echinococcus granulosus expressed conserved protein 0.0281 0.0335 0.3208
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0006 0.0061
Onchocerca volvulus 0.0027 0.0013 0.0278
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0009 0.0254
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0006 0.0061
Brugia malayi jmjC domain containing protein 0.0115 0.0126 0.3162
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0018 0.0132
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0009 0.06
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0009 0.06
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0006 0.0001
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0058 0.0177
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0099 0.0105 1
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0025 0.0012 0.0192
Onchocerca volvulus Alhambra homolog 0.0035 0.0024 0.0554
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0006 0.0111
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0081 0.0778
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0239 0.633
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.001 0.0678
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.0005 0.0002
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0012 0.0112
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0025 0.0012 0.0846
Loa Loa (eye worm) hypothetical protein 0.0053 0.0046 0.0556
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.7907 1 1
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0006 0.0006
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0041 0.0989
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0006 0.0008
Brugia malayi hypothetical protein 0.002 0.0005 0.0066
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0006 0.0276
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0009 0.06
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0094 0.0098 0.0096
Brugia malayi mbt repeat family protein 0.0093 0.0097 0.2424
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0273 0.0326 0.4104
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0058 0.0054
Loa Loa (eye worm) hypothetical protein 0.0027 0.0013 0.0138
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.002 0.0005 0.0137
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0019 0.0204
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.001 0.0146
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0006 0.0006
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0006 0.0276
Entamoeba histolytica hypothetical protein 0.0289 0.0346 0.9645
Brugia malayi DKFZp564C0469 protein 0.002 0.0005 0.0066
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0006 0.0001
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0099 0.0105 0.1302
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0013 0.0219
Mycobacterium ulcerans hypothetical protein 0.0035 0.0024 0.002
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0006 0.0001
Schistosoma mansoni cpg binding protein 0.0126 0.0139 0.1346
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0155 0.0176 0.22
Leishmania major DNA polymerase eta, putative 0.0023 0.0009 0.06
Schistosoma mansoni hypothetical protein 0.0124 0.0136 0.1315
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0055 0.0527
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.002 0.0005 0.0001
Schistosoma mansoni hypothetical protein 0.0031 0.0019 0.0179
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0025
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0006 0.0004
Onchocerca volvulus 0.0289 0.0345 0.8773
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0289 0.0346 0.3308
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0094 0.0098 0.0096
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0035 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0006 0.0047
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0006 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0009 0.06
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0005 0.0188
Echinococcus multilocularis tar DNA binding protein 0.0142 0.016 0.0513
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.002 0.0005 0.003
Echinococcus granulosus zinc finger protein 0.0038 0.0028 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0013 0.0235
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.0005 0.0066
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0011 0.0109
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0126 0.0401
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0006 0.0111
Giardia lamblia DINP protein human, muc B family 0.0023 0.0009 0.0457
Trypanosoma cruzi mitochondrial protein 99, putative 0.002 0.0005 0.0188
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0385 0.0467 0.1529
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0006 0.0111
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.002 0.0005 0.0137
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0273 0.0326 0.1062
Loa Loa (eye worm) hypothetical protein 0.0066 0.0064 0.0778
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0058 0.0561
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0009 0.0045
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0025 0.0012 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0038
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0096 0.0924
Echinococcus multilocularis musashi 0.0027 0.0013 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0015 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0006 0.0111
Echinococcus granulosus snurportin 1 0.064 0.079 0.7618
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0006 0.0099
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0006 0.0006
Schistosoma mansoni neutral sphingomyelinase 0.002 0.0005 0.0047
Loa Loa (eye worm) oxidoreductase 0.0021 0.0006 0.0041
Toxoplasma gondii histone lysine methyltransferase SET1 0.0234 0.0276 0.0273
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0024 0.0234
Mycobacterium leprae Probable lipase LipE 0.0035 0.0024 0.002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0099 0.0105 1
Entamoeba histolytica Ran family GTPase 0.0044 0.0035 0.0989
Schistosoma mansoni bromodomain containing protein 0.0091 0.0094 0.0912
Brugia malayi jmjC domain containing protein 0.0052 0.0045 0.1099
Loa Loa (eye worm) hypothetical protein 0.0093 0.0097 0.1197
Schistosoma mansoni hypothetical protein 0.0031 0.0019 0.0179
Leishmania major endonuclease/exonuclease protein-like protein 0.002 0.0005 0.0188
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.002 0.0005 0.0188
Giardia lamblia Histone acetyltransferase GCN5 0.0083 0.0085 0.7997
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0009 0.06
Brugia malayi CXXC zinc finger family protein 0.0117 0.0128 0.322
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0006 0.0003
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0006 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0006 0.0111
Loa Loa (eye worm) hypothetical protein 0.0035 0.0024 0.0278
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.001 0.0203
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0024 0.0048
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0006 0.0008
Giardia lamblia Sgs1 DNA helicase, putative 0.0024 0.001 0.0536
Echinococcus multilocularis tumor protein p63 0.0338 0.0407 0.1333
Brugia malayi Patched family protein 0.0018 0.0003 0.0015
Entamoeba histolytica acyl-coA synthetase, putative 0.0071 0.0069 0.1924
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0035 0.03
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0006 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0006 0.0111
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0299 0.0358 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0006 0.0011
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0039 0.0942
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0142 0.016 0.1993
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0052 0.0046 0.0444
Entamoeba histolytica hypothetical protein 0.0289 0.0346 0.9645
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0023 0.0008 0.0038
Giardia lamblia PHD finger protein 15 0.0035 0.0024 0.1957
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0009 0.0183
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0006 0.0061
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0018 0.0045
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0006 0.0056
Loa Loa (eye worm) hypothetical protein 0.0035 0.0024 0.0275
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0375 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0006 0.0111
Brugia malayi beta-lactamase 0.0035 0.0024 0.0574
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0006 0.0001
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0005 0.0002
Mycobacterium tuberculosis Probable exported protein 0.002 0.0005 0.0006
Plasmodium falciparum exodeoxyribonuclease III, putative 0.002 0.0005 0.0005
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.001 0.0203
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.7907 1 1
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0019 0.0425
Onchocerca volvulus 0.0035 0.0024 0.0559
Schistosoma mansoni chromobox protein 0.0084 0.0086 0.0832
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.002 0.0005 0.0005
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.7907 1 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0006 0.0001
Brugia malayi CHE-14 protein 0.0128 0.0142 0.3581
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0055 0.0527
Loa Loa (eye worm) hypothetical protein 0.0035 0.0024 0.0278
Echinococcus granulosus lamin dm0 0.0027 0.0013 0.0086
Brugia malayi hypothetical protein 0.0018 0.0003 0.0015
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0005 0.0000028226
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0009 0.06
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.002 0.0005 0.0002
Echinococcus granulosus dna polymerase kappa 0.0023 0.0009 0.0045
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0041 0.0989
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.002 0.0005 0.0047
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0043 0.0088
Schistosoma mansoni tar DNA-binding protein 0.0142 0.016 0.154
Schistosoma mansoni hypothetical protein 0.0536 0.0659 0.6366
Brugia malayi Patched family protein 0.0018 0.0003 0.0015
Schistosoma mansoni hypothetical protein 0.0066 0.0064 0.0616
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0273 0.0326 0.1062
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0024 0.0048
Echinococcus multilocularis Niemann Pick C1 protein 0.0427 0.0521 0.1708
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0099 0.0105 0.0223
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0009 0.06
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0006 0.0276
Entamoeba histolytica hypothetical protein 0.0289 0.0346 0.9645
Loa Loa (eye worm) hypothetical protein 0.0047 0.0039 0.0467
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0015 0.0285
Brugia malayi PHD-finger family protein 0.0044 0.0036 0.0863
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0055 0.5145
Brugia malayi RNA, U transporter 1 0.017 0.0195 0.4945
Echinococcus granulosus dnaJ subfamily B 0.0795 0.0987 0.9531
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0006 0.0099
Onchocerca volvulus Huntingtin homolog 0.0122 0.0134 0.336
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0005 0.0000028226
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.002 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0013 0.0235
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.002 0.0005 0.0188
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0047
Loa Loa (eye worm) T-complex protein 1 0.0025 0.0012 0.0115
Schistosoma mansoni intermediate filament proteins 0.0027 0.0013 0.0129
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.003
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0005 0.0003
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0006 0.0061
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0006 0.0006
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0006 0.0001
Brugia malayi intermediate filament protein 0.0027 0.0013 0.0293
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0024 0.0022
Brugia malayi topoisomerase 0.002 0.0005 0.0066
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0069 0.646
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.7907 1 1
Schistosoma mansoni glutaminase 0.0267 0.0317 0.3064
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0024 0.0574
Mycobacterium ulcerans beta-lactamase 0.0035 0.0024 0.002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0009 0.06
Trichomonas vaginalis ran, putative 0.0044 0.0035 0.0836
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.0005 0.0002
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0006 0.0017
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0081 0.7604
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0039 0.0028 0.0026
Onchocerca volvulus 0.0021 0.0006 0.0084
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0099 0.0105 0.0975
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0013 0.0235
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0035 0.0033
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.013
Schistosoma mansoni bromodomain containing protein 0.0019 0.0004 0.004
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0006 0.0006
Onchocerca volvulus 0.0037 0.0026 0.0611
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0038 0.0111
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.002 0.0005 0.0004
Echinococcus multilocularis lamin 0.0027 0.0013 0.0029
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0046 0.0096
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0105 0.0113 0.2839
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.002 0.0005 0.0004
Brugia malayi hypothetical protein 0.0289 0.0346 0.8781
Onchocerca volvulus 0.0117 0.0128 0.321
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.002 0.0005 0.0188
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0289 0.0346 0.1128
Loa Loa (eye worm) RecQ helicase 0.0024 0.001 0.0094
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0012 0.0247
Schistosoma mansoni ap endonuclease 0.0099 0.0105 0.1014
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0024 0.0235
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.002 0.0005 0.0188
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0099 0.0105 0.0332
Brugia malayi PHD-finger family protein 0.0035 0.0024 0.0568
Brugia malayi hypothetical protein 0.0245 0.029 0.7366
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0126 0.1175
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0006 0.0001
Plasmodium vivax importin-beta 2, putative 0.006 0.0055 0.0053
Leishmania major hypothetical protein, conserved 0.002 0.0005 0.0188
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0078 0.0079 0.7453
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0005 0.0149
Schistosoma mansoni tar DNA-binding protein 0.0142 0.016 0.154
Loa Loa (eye worm) hypothetical protein 0.0053 0.0046 0.0556
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0038 0.0325
Schistosoma mansoni sex comb on midleg homolog 0.0093 0.0097 0.0935
Brugia malayi RNA recognition motif domain containing protein 0.0142 0.016 0.4027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0006 0.0017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.025 0.0296 0.2858
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0311 0.0374 0.1222
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0006 0.0017
Schistosoma mansoni hypothetical protein 0.0536 0.0659 0.6366
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0254 0.0301 0.3794
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0005 0.0137
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0055 0.0053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0273 0.0326 0.3115
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0006 0.0047
Loa Loa (eye worm) glutaminase 2 0.0267 0.0317 0.3997
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.0005 0.003
Entamoeba histolytica hypothetical protein 0.0049 0.0041 0.1148
Loa Loa (eye worm) hypothetical protein 0.0071 0.0069 0.0843
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.1036 0.341
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0043 0.0088
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0069 0.1711
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0009 0.06
Loa Loa (eye worm) hypothetical protein 0.0155 0.0176 0.22
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0009 0.0005
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0006 0.0061
Brugia malayi exodeoxyribonuclease III family protein 0.0099 0.0105 0.2635
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0006 0.0017
Brugia malayi Pre-SET motif family protein 0.0254 0.0301 0.765
Loa Loa (eye worm) hypothetical protein 0.0057 0.0051 0.0622
Onchocerca volvulus 0.0021 0.0006 0.0096
Brugia malayi ecdysteroid receptor 0.0021 0.0006 0.0111
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0006 0.0035
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.0005 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0128 0.0142 0.3716
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0006 0.0001
Echinococcus granulosus tar DNA binding protein 0.0142 0.016 0.1503
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.0046 0.0046
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0025 0.0012 0.0324
Brugia malayi hypothetical protein 0.0018 0.0003 0.0015
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0081 0.201
Brugia malayi nuclear receptor NHR-88 0.0021 0.0006 0.0111
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0081 0.7604
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0098 0.0103 0.1278
Schistosoma mansoni importin beta-1 0.006 0.0055 0.0536
Echinococcus granulosus histone acetyltransferase MYST2 0.0105 0.0113 0.1053
Schistosoma mansoni DNA helicase recq5 0.0024 0.001 0.0096
Brugia malayi hypothetical protein 0.0098 0.0103 0.2587
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0006 0.0047
Schistosoma mansoni myelin transcription factor 1 myt1 0.0105 0.0113 0.1092
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0055 0.0166
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0086 0.0089 0.0279
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0006 0.0006
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0078 0.0079 0.2013
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.002 0.0005 0.0188
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0005 0.0188
Schistosoma mansoni transcription factor LCR-F1 0.0289 0.0346 0.3337
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.0375 0.4727
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0273 0.0326 0.3115
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.002 0.0005 0.0011
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.002 0.0005 0.0001
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0099 0.0105 0.0101
Schistosoma mansoni lamin 0.0027 0.0013 0.0129
Schistosoma mansoni tar DNA-binding protein 0.0142 0.016 0.154
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0078 0.0079 0.2206
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.0005 0.0002
Schistosoma mansoni ap endonuclease 0.0099 0.0105 0.1014
Toxoplasma gondii ABC1 family protein 0.0035 0.0024 0.0022
Brugia malayi chromobox protein homolog 3 0.0047 0.0039 0.0956
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0005 0.0044
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0035 0.3181
Schistosoma mansoni hypothetical protein 0.0124 0.0136 0.1315
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0375 1
Echinococcus multilocularis muscleblind protein 1 0.0155 0.0176 0.0566
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0044 0.1063
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0006 0.0276
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.001 0.0052
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0128 0.0142 0.1772
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0005 0.0188
Echinococcus granulosus mixed lineage leukemia protein mll 0.003 0.0018 0.0132
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0058 0.0561
Schistosoma mansoni eyes absent homolog 0.0098 0.0103 0.0996
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0081 0.7604
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0058 0.0121
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0375 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0088 0.1083
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0009 0.0124
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.002 0.0005 0.0011
Mycobacterium ulcerans glutaminase 0.0267 0.0317 0.0313
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0099 0.0105 0.0103
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.0005 0.0002
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0024 0.0066
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.029 0.2771
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2406 0.3028 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0005 0.0076
Schistosoma mansoni hypothetical protein 0.064 0.079 0.7629
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0239 0.633
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0006 0.0041
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0081 0.0252
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0047
Leishmania major GTP-binding protein, putative 0.0044 0.0035 0.3181
Schistosoma mansoni cpg binding protein 0.0117 0.0128 0.1236
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0035 0.0418
Brugia malayi Bromodomain containing protein 0.0054 0.0048 0.1171
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0005 0.0188
Plasmodium falciparum lipid/sterol:H+ symporter 0.0018 0.0003 0.0003
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0078 0.0079 0.0972
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0005 0.0076
Brugia malayi RNA binding protein 0.0142 0.016 0.4027
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0005 0.0188
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0069 0.1711
Echinococcus multilocularis geminin 0.0536 0.0659 0.2165
Echinococcus granulosus GPCR family 2 0.0031 0.0019 0.0136
Leishmania major DNA polymerase kappa, putative 0.0023 0.0009 0.06
Echinococcus granulosus synaptojanin 1 0.002 0.0005 0.0004
Schistosoma mansoni topbp1 0.002 0.0005 0.0044
Echinococcus granulosus histone acetyltransferase KAT2B 0.03 0.0359 0.3441
Loa Loa (eye worm) hypothetical protein 0.0046 0.0038 0.0454
Echinococcus granulosus dna polymerase eta 0.0023 0.0009 0.0045
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.001 0.0018
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.7907 1 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.001 0.0094
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0031 0.0706
Schistosoma mansoni coup transcription factor 0.0021 0.0006 0.0061
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0006 0.0008
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0024 0.002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0103 0.1274
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0019 0.0047
Loa Loa (eye worm) glutaminase 0.0267 0.0317 0.3997
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0005 0.0076
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.003
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.0046 0.0044
Brugia malayi nuclear hormone receptor 0.0021 0.0006 0.0111
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0006 0.0001
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0385 0.0467 0.4485
Onchocerca volvulus 0.0027 0.0013 0.0278
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0006 0.0047
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.002 0.0005 0.0188
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0086 0.2206
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.3659 0.4616 1
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0006 0.0061
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0012 0.0112
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0069 0.0064
Brugia malayi Patched family protein 0.0018 0.0003 0.0015
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0078 0.0079 0.7453
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0047
Loa Loa (eye worm) hypothetical protein 0.0071 0.0069 0.0843
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0094 0.0098 0.0096
Brugia malayi protein C24B5.3 0.0018 0.0003 0.0015
Echinococcus multilocularis mixed lineage leukemia protein mll 0.003 0.0018 0.0045
Loa Loa (eye worm) hypothetical protein 0.0128 0.0142 0.1772
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0006 0.0276
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0024 0.0022
Onchocerca volvulus Putative neutral sphingomyelinase 0.002 0.0005 0.0061
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.002 0.0005 0.0002
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0086 0.1062
Entamoeba histolytica recQ family helicase, putative 0.0024 0.001 0.0276
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0041
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0035 0.0856
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0069 0.1924
Loa Loa (eye worm) hypothetical protein 0.0066 0.0063 0.0766
Onchocerca volvulus 0.005 0.0043 0.1034
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0006 0.0006
Leishmania major importin beta-1 subunit, putative 0.0049 0.0041 0.3738
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0006 0.0047
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0005 0.0137
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0034 0.0096
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.002 0.0005 0.0011
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0009 0.0005
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0035 0.3181
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0005 0.0188
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.0005 0.003
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0058 0.0054
Onchocerca volvulus 0.002 0.0005 0.0061
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0086 0.2206
Giardia lamblia TCP-1 chaperonin subunit beta 0.0025 0.0012 0.0707
Schistosoma mansoni lamin 0.0027 0.0013 0.0129
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0023 0.0009 0.0545
Echinococcus multilocularis polycomb protein SCMH1 0.0093 0.0097 0.0305
Brugia malayi Patched related family protein 4 0.0018 0.0003 0.0015
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.0005 0.0002
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0005 0.0076
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.001 0.0052
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0025 0.0012 0.0069
Onchocerca volvulus 0.0021 0.0006 0.0084
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.002 0.0005 0.0188
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0012 0.0112
Schistosoma mansoni DNA helicase recq1 0.0024 0.001 0.0096
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0013 0.0235
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.0006 0.0001
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.004 0.0031 0.0706
Echinococcus multilocularis expressed conserved protein 0.0281 0.0335 0.1094
Echinococcus multilocularis neutral sphingomyelinase 0.002 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.003
Echinococcus multilocularis synaptojanin 1 0.002 0.0005 0.0001
Echinococcus granulosus intermediate filament protein 0.0027 0.0013 0.0086
Echinococcus multilocularis dna polymerase eta 0.0023 0.0009 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0009 0.06
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.002 0.0005 0.0011
Schistosoma mansoni ran 0.0044 0.0035 0.0342
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0047
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0025
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0035 0.0291
Loa Loa (eye worm) acetyltransferase 0.0311 0.0374 0.4716
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.001 0.001
Brugia malayi CCR4 0.002 0.0005 0.0076
Onchocerca volvulus 0.0052 0.0046 0.1111
Onchocerca volvulus 0.0035 0.0024 0.0559
Loa Loa (eye worm) hypothetical protein 0.0326 0.0393 0.4962
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0019 0.0047
Schistosoma mansoni hypothetical protein 0.0031 0.0019 0.0179
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0009 0.06
Echinococcus multilocularis chromobox protein 1 0.0084 0.0086 0.027
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0005 0.0149
Echinococcus granulosus sterol regulatory element binding protein 0.0128 0.0142 0.1334
Schistosoma mansoni tar DNA-binding protein 0.0142 0.016 0.154
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0253 0.6707
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.002 0.0005 0.0188
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.0266 0.0572
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0081 0.0738
Echinococcus multilocularis dnaJ subfamily B 0.0795 0.0987 0.325
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0041 0.0989
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0099 0.0105 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.0086 0.027
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.006 0.0055 0.0672
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0025 0.0012 0.0846
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0024 0.0278
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0047
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0041
Loa Loa (eye worm) beta-lactamase 0.0035 0.0024 0.0278
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.002 0.0005 0.0011
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0005 0.0137
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.7907 1 1
Echinococcus granulosus Niemann Pick C1 protein 0.0299 0.0358 0.3431
Brugia malayi Bromodomain containing protein 0.0046 0.0037 0.0906
Onchocerca volvulus 0.0021 0.0006 0.0084
Schistosoma mansoni hypothetical protein 0.0031 0.0019 0.0179
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0024 0.2097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0273 0.0326 0.3145
Leishmania major pantothenate kinase subunit, putative 0.0023 0.0009 0.0545
Schistosoma mansoni nocturnin 0.002 0.0005 0.0047
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0071 0.0069 0.0064
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0072 0.0878
Echinococcus multilocularis peregrin 0.0046 0.0037 0.0109
Schistosoma mansoni hypothetical protein 0.005 0.0043 0.0415
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0006 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0009 0.06
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0058 0.052
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.0046 0.0042
Brugia malayi Muscleblind-like protein 0.0155 0.0176 0.4442
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0005 0.0188
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.001 0.0018
Schistosoma mansoni cript-related 0.002 0.0005 0.0047
Brugia malayi TAR-binding protein 0.0142 0.016 0.4027
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0303 0.0364 0.3516
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0069 0.646
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0006 0.0055
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0006 0.0061
Schistosoma mansoni hypothetical protein 0.0795 0.0987 0.9533
Echinococcus multilocularis lamin dm0 0.0027 0.0013 0.0029
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0024 0.0537
Echinococcus multilocularis GPCR, family 2 0.0031 0.0019 0.0047
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0071 0.0069 0.0145
Echinococcus multilocularis snurportin 1 0.064 0.079 0.2598
Schistosoma mansoni tar DNA-binding protein 0.0142 0.016 0.154
Brugia malayi Patched family protein 0.0018 0.0003 0.0015
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0005 0.0076

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 14.923 uM PUBCHEM_BIOASSAY: Discovery of Small Molecule Probes for H1N1 Influenza NS1A. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504399] ChEMBL. No reference
Potency (functional) 0.5174 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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