Detailed information for compound 1351910

Basic information

Technical information
  • TDR Targets ID: 1351910
  • Name: N-[(E)-1-(1H-benzimidazol-2-yl)-2-(3,4-dimeth oxyphenyl)ethenyl]benzamide
  • MW: 399.442 | Formula: C24H21N3O3
  • H donors: 2 H acceptors: 2 LogP: 4.36 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)/C=C(\c1nc2c([nH]1)cccc2)/NC(=O)c1ccccc1
  • InChi: 1S/C24H21N3O3/c1-29-21-13-12-16(15-22(21)30-2)14-20(27-24(28)17-8-4-3-5-9-17)23-25-18-10-6-7-11-19(18)26-23/h3-15H,1-2H3,(H,25,26)(H,27,28)/b20-14+
  • InChiKey: NLKKHCJNRCVFBB-XSFVSMFZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(E)-1-(1H-benzimidazol-2-yl)-2-(3,4-dimethoxyphenyl)vinyl]benzamide
  • SMR000162930
  • ZINC04019637
  • MLS000544624
  • N-[1-(1H-benzimidazol-2-yl)-2-(3,4-dimethoxyphenyl)vinyl]benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0047 0.0452 0.1615
Trichomonas vaginalis ap endonuclease, putative 0.0025 0.0115 0.0332
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.0434 0.0498
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Brugia malayi Carboxylesterase family protein 0.0025 0.0114 0.0212
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0028 0.0159 0.0296
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0107 0.1344 1
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.012 0.1536 0.1535
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0046 0.0434 0.0364
Echinococcus granulosus tfiia large subunit 0.0037 0.0298 0.031
Echinococcus granulosus geminin 0.0249 0.3467 0.4677
Onchocerca volvulus 0.0027 0.0142 0.0477
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0047 0.0452 0.4602
Onchocerca volvulus 0.0028 0.0159 0.0539
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.0434 0.0498
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.0434 0.0379
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0047 0.0452 0.1615
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0047 0.0452 0.1615
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.017
Brugia malayi Trypsin-like protease protein 5 0.0027 0.0142 0.0264
Loa Loa (eye worm) aspartyl protease 6 0.004 0.0347 0.0519
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Loa Loa (eye worm) hypothetical protein 0.0164 0.2193 0.3278
Brugia malayi hypothetical protein 0.0027 0.0142 0.0264
Brugia malayi hypothetical protein 0.0046 0.0434 0.0808
Echinococcus multilocularis caspase 2 0.0033 0.0241 0.017
Brugia malayi putative neuropeptide receptor NPR1 0.0046 0.0434 0.0808
Echinococcus granulosus neuropeptide receptor 0.0046 0.0434 0.0498
Onchocerca volvulus 0.0025 0.0114 0.0375
Trichomonas vaginalis spcc417.12 protein, putative 0.0025 0.0114 0.0325
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0164 0.2193 0.2224
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0027 0.014 0.0528
Echinococcus granulosus caspase 2 0.0033 0.0241 0.0233
Echinococcus granulosus serotonin transporter 0.0164 0.2193 0.2922
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0047 0.0452 0.1615
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0047 0.0452 0.1615
Echinococcus granulosus Tolloid protein 1 0.0039 0.0322 0.0344
Brugia malayi hypothetical protein 0.0152 0.2014 0.3753
Echinococcus multilocularis apoptotic protease activating factor 1 0.0023 0.0092 0.0019
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0028 0.0159 0.009
Brugia malayi hypothetical protein 0.0202 0.2759 0.5142
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0027 0.014 0.0204
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0028 0.0159 0.0119
Schistosoma mansoni tfiia large subunit 0.0037 0.0298 0.0236
Treponema pallidum sodium- and chloride- dependent transporter 0.0164 0.2193 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.0434 0.0498
Toxoplasma gondii calcium binding egf domain-containing protein 0.0037 0.0302 0.1028
Loa Loa (eye worm) hypothetical protein 0.0183 0.2475 0.3699
Brugia malayi Cytochrome P450 family protein 0.0047 0.0452 0.0842
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0037 0.0302 0.0451
Loa Loa (eye worm) PAN domain-containing protein 0.0018 0.0011 0.0016
Brugia malayi hypothetical protein 0.004 0.0347 0.0647
Brugia malayi hypothetical protein 0.0046 0.0434 0.0808
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Schistosoma mansoni hypothetical protein 0.0023 0.0092 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0434 0.0364
Echinococcus multilocularis microtubule associated protein 2 0.0507 0.733 0.7311
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0142 0.0073
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0022 0.0072 0.0108
Echinococcus granulosus orexin receptor type 2 0.0046 0.0434 0.0498
Schistosoma mansoni hypothetical protein 0.0028 0.0165 0.0098
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0142 0.0073
Toxoplasma gondii aspartyl protease ASP3 0.004 0.0347 0.1188
Onchocerca volvulus 0.0164 0.2193 0.7942
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0035 0.0094
Echinococcus granulosus tachykinin peptides receptor 99D 0.0046 0.0434 0.0498
Echinococcus granulosus g protein coupled receptor 0.0046 0.0434 0.0498
Loa Loa (eye worm) hypothetical protein 0.0027 0.014 0.0209
Schistosoma mansoni sodium/chloride dependent transporter 0.0164 0.2193 0.2224
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0027 0.014 0.0093
Leishmania major hypothetical protein, conserved 0.0044 0.0398 0.136
Schistosoma mansoni amine GPCR 0.0046 0.0434 0.0379
Trypanosoma cruzi cytochrome P450, putative 0.0165 0.2208 0.816
Echinococcus granulosus somatostatin receptor 0.0046 0.0434 0.0498
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0046 0.0434 0.0648
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.014 0.1842 0.6803
Loa Loa (eye worm) PAN domain-containing protein 0.0018 0.0011 0.0016
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0046 0.0434 0.0808
Echinococcus granulosus cytochrome P450 2K1 0.0047 0.0452 0.0523
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0047 0.0452 0.1615
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0047 0.0452 0.1615
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0016
Echinococcus granulosus acetylcholinesterase 0.0147 0.1939 0.2572
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0047 0.0452 0.4602
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0159 0.0359
Onchocerca volvulus 0.0046 0.0434 0.1539
Brugia malayi hypothetical protein 0.0046 0.0434 0.0808
Giardia lamblia Synaptic glycoprotein SC2 0.0027 0.014 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.017
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0047 0.0452 0.1615
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0107 0.1344 0.1752
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0452 0.0675
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0028 0.0159 0.0237
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0046 0.0434 0.0498
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0047 0.0452 0.1615
Loa Loa (eye worm) hypothetical protein 0.0147 0.1939 0.2898
Loa Loa (eye worm) melatonin receptor type 1A 0.0046 0.0434 0.0648
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0025 0.0115 0.039
Echinococcus granulosus synaptic glycoprotein sc2 0.0027 0.014 0.0093
Loa Loa (eye worm) hypothetical protein 0.0202 0.2759 0.4124
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0046 0.0434 0.0364
Schistosoma mansoni amine GPCR 0.0046 0.0434 0.0379
Plasmodium falciparum cysteine repeat modular protein 1 0.0044 0.0398 0.2303
Toxoplasma gondii hypothetical protein 0.0023 0.0081 0.0249
Plasmodium falciparum plasmepsin V 0.004 0.0347 0.1893
Brugia malayi hypothetical protein 0.0046 0.0434 0.0808
Brugia malayi PAN domain containing protein 0.0018 0.0011 0.002
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0027 0.0142 0.007
Echinococcus granulosus peptide allatostatin:somatostatin 0.0046 0.0434 0.0498
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0028 0.0159 0.0237
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0434 0.0364
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0028 0.0159 0.0087
Loa Loa (eye worm) hypothetical protein 0.0027 0.0142 0.0212
Plasmodium falciparum plasmepsin I 0.0107 0.1344 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.0434 0.0648
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0028 0.0159 0.0119
Onchocerca volvulus 0.0046 0.0434 0.1539
Plasmodium falciparum polyprenol reductase, putative 0.0027 0.014 0.0204
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.0434 0.0379
Echinococcus multilocularis tissue type plasminogen activator 0.0044 0.0398 0.0328
Echinococcus multilocularis gamma secretase subunit aph 1 0.0056 0.0582 0.0514
Echinococcus multilocularis para nitrobenzyl esterase 0.0025 0.0114 0.0042
Onchocerca volvulus 0.0044 0.0398 0.1408
Loa Loa (eye worm) hypothetical protein 0.0028 0.0165 0.0247
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0028 0.0159 0.0296
Brugia malayi Pepsin A precursor 0.004 0.0347 0.0647
Loa Loa (eye worm) hypothetical protein 0.0027 0.014 0.0209
Brugia malayi Carboxylesterase family protein 0.0025 0.0114 0.0212
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0047 0.0452 0.1563
Brugia malayi hypothetical protein 0.0025 0.0114 0.0212
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0028 0.0159 0.009
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.004 0.0347 0.0288
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0027 0.014 0.0528
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0047 0.0452 0.4602
Loa Loa (eye worm) hypothetical protein 0.0202 0.2759 0.4124
Brugia malayi Eukaryotic aspartyl protease family protein 0.004 0.0347 0.0647
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0039 0.0322 0.0481
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0047 0.0452 0.4602
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0047 0.0452 0.1615
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.0434 0.0379
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0434 0.0379
Plasmodium falciparum transporter, putative 0.0028 0.0159 0.0359
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0184 0.2495 0.2541
Brugia malayi hypothetical protein 0.0023 0.0092 0.0171
Schistosoma mansoni neuroligin 3 (S09 family) 0.0025 0.0114 0.0043
Echinococcus granulosus neuropeptide receptor A26 0.0046 0.0434 0.0498
Schistosoma mansoni opsin-like receptor 0.0046 0.0434 0.0379
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0027 0.014 0.0455
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0147 0.1939 0.1957
Brugia malayi PAN domain containing protein 0.0018 0.0011 0.002
Echinococcus granulosus tfiia large subunit 0.0037 0.0298 0.031
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0035 0.0094
Loa Loa (eye worm) runx1 0.0025 0.0121 0.0181
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0025 0.0115 0.0004
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0046 0.0434 0.0498
Loa Loa (eye worm) carboxylesterase 0.0025 0.0114 0.017
Schistosoma mansoni opsin-like receptor 0.0046 0.0434 0.0379
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0434 0.0379
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.004 0.0347 0.0288
Echinococcus granulosus g protein coupled receptor 0.0046 0.0434 0.0498
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0434 0.0364
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Toxoplasma gondii exonuclease III APE 0.0025 0.0115 0.0367
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II 0.0376 0.5366 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0361 0.054
Schistosoma mansoni sodium/chloride dependent transporter 0.0028 0.0162 0.0094
Loa Loa (eye worm) hypothetical protein 0.0027 0.0142 0.0212
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0434 0.0498
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0037 0.0302 0.0451
Mycobacterium ulcerans hypothetical protein 0.0074 0.0849 0.3509
Onchocerca volvulus 0.0025 0.0114 0.0375
Brugia malayi Carboxylesterase family protein 0.0147 0.1939 0.3613
Brugia malayi PAN domain containing protein 0.0018 0.0011 0.002
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0028 0.0159 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0434 0.0364
Loa Loa (eye worm) carboxylesterase 0.0147 0.1939 0.2898
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0434 0.0498
Plasmodium falciparum plasmepsin VI 0.0107 0.1344 1
Schistosoma mansoni survival motor neuron protein 0.0031 0.0206 0.014
Schistosoma mansoni neuropeptide receptor 0.0046 0.0434 0.0379
Brugia malayi Trypsin family protein 0.0183 0.2475 0.4613
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0183 0.2475 0.252
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0398 0.1441
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0198 0.2704 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0025 0.0115 0.0058
Brugia malayi Cytochrome P450 family protein 0.0165 0.2208 0.4115
Loa Loa (eye worm) hypothetical protein 0.0101 0.1256 0.1877
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0047 0.0452 0.1615
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0434 0.0498
Schistosoma mansoni biogenic amine receptor 0.0046 0.0434 0.0379
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.0434 0.0498
Echinococcus granulosus tissue type plasminogen activator 0.0044 0.0398 0.0448
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0027 0.014 0.0528
Plasmodium falciparum plasmepsin VIII, putative 0.004 0.0347 0.1893
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0046 0.0434 0.0808
Mycobacterium tuberculosis Conserved hypothetical protein 0.0074 0.0849 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0142 0.0073
Trypanosoma brucei DNA polymerase beta thumb, putative 0.002 0.0038 0.0011
Plasmodium falciparum plasmepsin IV 0.0107 0.1344 1
Schistosoma mansoni gliotactin 0.0025 0.0114 0.0043
Schistosoma mansoni biogenic amine receptor 0.0046 0.0434 0.0379
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0047 0.0452 0.4602
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Loa Loa (eye worm) CYP4Cod1 0.0165 0.2208 0.33
Echinococcus granulosus snurportin 1 0.0106 0.1321 0.172
Brugia malayi Transcription factor IIA, alpha/beta subunit family protein 0.0037 0.0298 0.0554
Leishmania major mitochondrial DNA polymerase beta 0.014 0.1842 0.6772
Schistosoma mansoni histamine h1 receptor 0.0046 0.0434 0.0379
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0164 0.2193 0.4088
Schistosoma mansoni ap endonuclease 0.0025 0.0115 0.0044
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0022 0.0072 0.0234
Echinococcus multilocularis sodium and chloride dependent glycine 0.0028 0.0159 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.014 0.0528
Echinococcus granulosus neuropeptide FF receptor 2 0.0046 0.0434 0.0498
Onchocerca volvulus Neuropeptide F receptor homolog 0.0046 0.0434 0.1539
Brugia malayi PAN domain containing protein 0.0018 0.0011 0.002
Brugia malayi PAN domain containing protein 0.0018 0.0011 0.002
Echinococcus granulosus sodium and chloride dependent glycine 0.0028 0.0159 0.0119
Loa Loa (eye worm) hypothetical protein 0.0107 0.1344 0.2009
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0027 0.014 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.0434 0.0379
Brugia malayi Trypsin family protein 0.0027 0.0142 0.0264
Schistosoma mansoni hypothetical protein 0.0031 0.0206 0.014
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.017
Mycobacterium ulcerans hypothetical protein 0.0027 0.014 0.0124
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Schistosoma mansoni egf-like domain protein 0.0037 0.0302 0.0241
Schistosoma mansoni lozenge 0.0025 0.0121 0.0051
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0162 0.0094
Brugia malayi ORL1-like opioid receptor 0.0046 0.0434 0.0808
Brugia malayi hypothetical protein 0.004 0.0347 0.0647
Brugia malayi PAN domain containing protein 0.0018 0.0011 0.002
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0142 0.0073
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.0434 0.0498
Echinococcus multilocularis G-protein coupled receptor, putative 0.0046 0.0434 0.0364
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0107 0.1344 0.4707
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0027 0.0142 0.0264
Onchocerca volvulus 0.0046 0.0434 0.1539
Schistosoma mansoni sodium-dependent amino acid transporter 0.0028 0.0159 0.009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0434 0.0379
Echinococcus multilocularis acetylcholinesterase 0.0147 0.1939 0.188
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0046 0.0434 0.0364
Brugia malayi Serotonin receptor 0.0046 0.0434 0.0808
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0025 0.0115 0.0299
Trypanosoma cruzi cytochrome P450, putative 0.0165 0.2208 0.816
Loa Loa (eye worm) hypothetical protein 0.0028 0.0159 0.0237
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0434 0.0379
Echinococcus multilocularis neuropeptide receptor A26 0.0046 0.0434 0.0364
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0137
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0027 0.014 0.0483
Toxoplasma gondii cytochrome p450 superfamily protein 0.0047 0.0452 0.1557
Schistosoma mansoni amine GPCR 0.0046 0.0434 0.0379
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0041 0.0361 0.0673
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0039 0.0322 0.0262
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0027 0.014 0.0528
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0434 0.0379
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0025 0.0115 0.0012
Echinococcus multilocularis allatostatin A receptor 0.0046 0.0434 0.0364
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0022 0.0072 0.0234
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0028 0.0159 0.0522
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0142 0.0073
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0027 0.014 0.0483
Brugia malayi hypothetical protein 0.0046 0.0434 0.0808
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0047 0.0452 0.4602
Echinococcus granulosus alpha 1A adrenergic receptor 0.0046 0.0434 0.0498
Onchocerca volvulus 0.0023 0.0092 0.0294
Loa Loa (eye worm) hypothetical protein 0.0465 0.6691 1
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0027 0.014 0.0528
Mycobacterium leprae putative cytochrome p450 0.0047 0.0452 0.5
Loa Loa (eye worm) serotonin transporter b 0.0164 0.2193 0.3278
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0434 0.0364
Plasmodium falciparum plasmepsin II 0.0107 0.1344 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0027 0.0142 0.0073
Onchocerca volvulus 0.0046 0.0434 0.1539
Brugia malayi Carboxylesterase family protein 0.0025 0.0114 0.0212
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0028 0.0159 0.009
Schistosoma mansoni hypothetical protein 0.0027 0.0142 0.0073
Loa Loa (eye worm) TK/ROR protein kinase 0.0044 0.0398 0.0594
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0027 0.014 0.0528
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0027 0.0142 0.007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0084 0.0126
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0046 0.0434 0.0364
Brugia malayi Dopamine receptor protein 2 0.0046 0.0434 0.0808
Onchocerca volvulus 0.0046 0.0434 0.1539
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0028 0.0159 0.0522
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0027 0.014 0.0455
Mycobacterium ulcerans hypothetical protein 0.0027 0.0142 0.0134
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0047 0.0452 0.4602
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0434 0.0379
Plasmodium vivax aspartyl protease, putative 0.004 0.0347 0.1893
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.0434 0.0364
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0025 0.0114 0.0325
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Loa Loa (eye worm) transcription factor SMAD2 0.0104 0.13 0.1943
Plasmodium vivax aspartyl protease, putative 0.004 0.0347 0.1893
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Trypanosoma cruzi Aph-1 protein, putative 0.0022 0.007 0.0224
Echinococcus granulosus allatostatin A receptor 0.0046 0.0434 0.0498
Toxoplasma gondii aspartyl protease ASP1 0.0107 0.1344 0.4707
Brugia malayi MAP kinase sur-1 0.0022 0.0072 0.0135
Loa Loa (eye worm) hypothetical protein 0.0028 0.0159 0.0237
Echinococcus granulosus G protein coupled receptor 139 0.0046 0.0434 0.0498
Onchocerca volvulus 0.0025 0.0114 0.0375
Schistosoma mansoni hypothetical protein 0.0046 0.0434 0.0379
Trypanosoma brucei mitochondrial DNA polymerase beta 0.014 0.1842 0.6772
Loa Loa (eye worm) hypothetical protein 0.0028 0.0159 0.0237
Echinococcus granulosus survival motor neuron protein 1 0.0152 0.2014 0.2675
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Brugia malayi Protein kinase domain containing protein 0.0044 0.0398 0.0741
Schistosoma mansoni memapsin-2 (A01 family) 0.0514 0.7424 0.7709
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0046 0.0434 0.0379
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0434 0.0498
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0027 0.014 0.0393
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0047 0.0452 0.4602
Echinococcus granulosus sodium and chloride dependent glycine 0.0028 0.0159 0.0119
Schistosoma mansoni biogenic amine receptor 0.0046 0.0434 0.0379
Brugia malayi cytochrome P450 0.0047 0.0452 0.0842
Loa Loa (eye worm) hypothetical protein 0.0152 0.2014 0.301
Toxoplasma gondii calcium binding egf domain-containing protein 0.0037 0.0302 0.1028
Onchocerca volvulus 0.0027 0.0142 0.0477
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0047 0.0452 0.4602
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0046 0.0434 0.0648
Brugia malayi GnHR receptor homolog 0.0046 0.0434 0.0808
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0047 0.0452 0.4602
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0046 0.0434 0.0364
Brugia malayi G protein-coupled receptor F59B2.13 0.0046 0.0434 0.0808
Plasmodium vivax plasmepsin V, putative 0.004 0.0347 0.1893
Echinococcus multilocularis serotonin receptor 0.0046 0.0434 0.0364
Brugia malayi hypothetical protein 0.0046 0.0434 0.0808
Echinococcus granulosus g protein coupled receptor 0.0046 0.0434 0.0498
Brugia malayi Serotonin receptor 0.0046 0.0434 0.0808
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0025 0.0114 0.0043
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0046 0.0434 0.1539
Brugia malayi larval opioid receptor 0.0046 0.0434 0.0808
Brugia malayi Calcium binding EGF domain containing protein 0.0037 0.0302 0.0563
Mycobacterium leprae Conserved hypothetical protein 0.0047 0.0452 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0324 0.4596 0.6232
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0047 0.0452 0.4602
Echinococcus multilocularis sodium and chloride dependent glycine 0.0028 0.0159 0.0087
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0107 0.1344 0.1281
Echinococcus multilocularis Protein lozenge 0.0025 0.0121 0.0049
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0434 0.0364
Echinococcus multilocularis Tolloid protein 1 0.0039 0.0322 0.0252
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0047 0.0452 0.1642
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0022 0.0072 0.0234
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0434 0.0379
Schistosoma mansoni hypothetical protein 0.0249 0.3467 0.3559
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0027 0.014 0.0455
Brugia malayi latrophilin 2 splice variant baaae 0.0028 0.0165 0.0308
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Brugia malayi G protein-coupled receptor 0.0046 0.0434 0.0808
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0025 0.0114 0.0043
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0047 0.0452 0.4602
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.004 0.0347 0.1188
Echinococcus multilocularis sex peptide receptor 0.0046 0.0434 0.0364
Brugia malayi hypothetical protein 0.0046 0.0434 0.0808
Brugia malayi Cytochrome P450 family protein 0.0047 0.0452 0.0842
Brugia malayi G-protein coupled receptor 0.0046 0.0434 0.0808
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0047 0.0452 0.1615
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0047 0.0452 0.1615
Schistosoma mansoni ap endonuclease 0.0025 0.0115 0.0044
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0047 0.0452 0.1642
Schistosoma mansoni tfiia large subunit 0.0037 0.0298 0.0236
Echinococcus granulosus neuroligin 0.0025 0.0114 0.0057
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.0376 0.5366 0.7293
Echinococcus multilocularis synaptic glycoprotein sc2 0.0027 0.014 0.0068
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0434 0.0364
Loa Loa (eye worm) hypothetical protein 0.0028 0.0159 0.0237
Echinococcus multilocularis dro:myosuppressin receptor 0.0046 0.0434 0.0364
Echinococcus granulosus tumor protein p63 0.0114 0.1442 0.1887
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0046 0.0434 0.0379
Loa Loa (eye worm) hypothetical protein 0.0028 0.0159 0.0237
Onchocerca volvulus 0.0046 0.0434 0.1539
Echinococcus multilocularis geminin 0.0249 0.3467 0.3419
Echinococcus granulosus g-protein coupled receptor 0.0046 0.0434 0.0498
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0142 0.0073
Echinococcus multilocularis orexin receptor type 2 0.0046 0.0434 0.0364
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.002 0.0038 0.0105
Schistosoma mansoni neuropeptide f receptor 76f 0.0046 0.0434 0.0379
Toxoplasma gondii hypothetical protein 0.0028 0.0159 0.0522
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0066 0.0736 0.2628
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0028 0.0159 0.009
Loa Loa (eye worm) hypothetical protein 0.0028 0.0159 0.0237
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Toxoplasma gondii PAN domain-containing protein 0.0207 0.2844 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0046 0.0434 0.0379
Onchocerca volvulus 0.0046 0.0434 0.1539
Echinococcus granulosus hypothetical protein 0.0046 0.0434 0.0498
Loa Loa (eye worm) hypothetical protein 0.0044 0.0398 0.0594
Echinococcus multilocularis fibrillin 1 0.0037 0.0302 0.0231
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0046 0.0434 0.0364
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0337 0.0277
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0027 0.014 1
Onchocerca volvulus 0.0028 0.0159 0.0539
Schistosoma mansoni cathepsin D (A01 family) 0.0277 0.3888 0.4001
Echinococcus multilocularis fmrfamide receptor 0.0046 0.0434 0.0364
Echinococcus multilocularis neuropeptide receptor 0.0046 0.0434 0.0364
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0027 0.014 0.0204
Brugia malayi Carboxylesterase family protein 0.0025 0.0114 0.0212
Loa Loa (eye worm) hypothetical protein 0.0183 0.2475 0.3699
Schistosoma mansoni hypothetical protein 0.0044 0.0398 0.0341
Echinococcus granulosus 7tm_1 domain containing protein 0.0046 0.0434 0.0498
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.066 0.9609 1
Brugia malayi G-protein coupled receptor 0.0046 0.0434 0.0808
Echinococcus granulosus neuropeptide receptor 0.0046 0.0434 0.0498
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0025 0.0115 0.0042
Onchocerca volvulus 0.0031 0.0206 0.071
Brugia malayi gamma-secretase subunit aph-1 0.0056 0.0582 0.1085
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0027 0.014 0.007
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0142 0.0073
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0046 0.0434 0.0379
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0434 0.0364
Trypanosoma cruzi Aph-1 protein, putative 0.0022 0.007 0.0224
Brugia malayi AKH receptor 0.0046 0.0434 0.0808
Echinococcus granulosus dro:myosuppressin receptor 0.0046 0.0434 0.0498
Plasmodium falciparum amino acid transporter, putative 0.0028 0.0159 0.0359
Onchocerca volvulus 0.0027 0.0142 0.0477
Echinococcus granulosus sex peptide receptor 0.0046 0.0434 0.0498
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0046 0.0434 0.0498
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0142 0.0212
Trypanosoma cruzi cruzipain precursor, putative 0.002 0.0035 0.0094
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0047 0.0452 0.4602
Trypanosoma brucei protein kinase, putative 0.0022 0.0072 0.0141
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.004 0.0347 0.0288
Onchocerca volvulus 0.0046 0.0434 0.1539
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0046 0.0434 0.0808
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0027 0.0142 0.0095
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0047 0.0452 0.4602
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0434 0.0498
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0028 0.0159 0.0522
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0041 0.0361 0.054
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0027 0.014 0.0393
Leishmania major cytochrome p450-like protein 0.0047 0.0452 0.1563
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0027 0.014 0.007
Plasmodium falciparum plasmepsin X 0.004 0.0347 0.1893
Echinococcus multilocularis serotonin receptor 0.0046 0.0434 0.0364
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0027 0.014 1
Brugia malayi Melatonin receptor type 1A 0.0046 0.0434 0.0808
Schistosoma mansoni adenoreceptor 0.0046 0.0434 0.0379
Loa Loa (eye worm) hypothetical protein 0.0465 0.6691 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0025 0.0114 0.0043
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0047 0.0452 0.1615
Loa Loa (eye worm) hypothetical protein 0.0042 0.037 0.0554
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0056 0.0582 0.0871
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0047 0.0452 0.1615
Echinococcus multilocularis tfiia large subunit 0.0037 0.0298 0.0227
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.0434 0.0364
Onchocerca volvulus 0.0202 0.2759 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0142 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.014 0.0528
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.004 0.0347 0.0288
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0027 0.0142 0.0073
Schistosoma mansoni neuropeptide receptor 0.0046 0.0434 0.0379
Loa Loa (eye worm) hypothetical protein 0.004 0.0347 0.0519
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0016
Schistosoma mansoni hypothetical protein 0.0047 0.0452 0.0398
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0028 0.0159 0.0087
Echinococcus multilocularis serotonin transporter 0.0164 0.2193 0.2137
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0434 0.0498
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0434 0.0364
Echinococcus granulosus microtubule associated protein 2 0.0507 0.733 1
Loa Loa (eye worm) cytochrome P450 0.0047 0.0452 0.0675
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0028 0.0159 0.009
Loa Loa (eye worm) hypothetical protein 0.0027 0.0142 0.0212
Echinococcus multilocularis snurportin 1 0.0106 0.1321 0.1258
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0022 0.0072 0.0218
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0198 0.2704 0.5039
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0022 0.0072 0.0141
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0046 0.0434 0.0379
Brugia malayi Calcitonin receptor-like protein seb-1 0.0041 0.0361 0.0673
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0434 0.0364
Leishmania major cytochrome p450-like protein 0.0165 0.2208 0.8142
Echinococcus multilocularis neuropeptide s receptor 0.0046 0.0434 0.0364
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0434 0.0379
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.0434 0.0379
Onchocerca volvulus 0.0025 0.0114 0.0375
Loa Loa (eye worm) cytochrome P450 family protein 0.0165 0.2208 0.33
Brugia malayi PAN domain containing protein 0.0018 0.0011 0.002
Loa Loa (eye worm) norepinephrine transporter 0.0164 0.2193 0.3278
Loa Loa (eye worm) hypothetical protein 0.0117 0.1499 0.224
Brugia malayi sulfakinin receptor protein 0.0046 0.0434 0.0808
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0028 0.0159 0.5
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0028 0.0159 0.0119
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0025 0.0114 0.0042
Loa Loa (eye worm) PAN domain-containing protein 0.0018 0.0011 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0047 0.0452 0.4602
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0024 0.0109 0.0037
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.004 0.0347 0.0288
Brugia malayi Trypsin family protein 0.0027 0.0142 0.0264
Brugia malayi Dopamine receptor protein 1 0.0046 0.0434 0.0808
Echinococcus multilocularis carboxylesterase 5A 0.0147 0.1939 0.188
Brugia malayi Synaptic glycoprotein SC2 0.0027 0.014 0.026
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0142 0.0073
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Onchocerca volvulus 0.0046 0.0434 0.1539
Echinococcus multilocularis enteropeptidase 0.004 0.0337 0.0266
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0027 0.014 0.0483
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.0434 0.0498
Echinococcus granulosus enteropeptidase 0.004 0.0337 0.0364
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Echinococcus multilocularis transmembrane protease serine 3 0.0027 0.0142 0.007
Brugia malayi putative neuropeptide receptor 0.0046 0.0434 0.0808
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0027 0.0142 0.0095
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0028 0.0159 0.0296
Schistosoma mansoni caspase-7 (C14 family) 0.0033 0.0241 0.0177
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0434 0.0364
Onchocerca volvulus 0.0046 0.0434 0.1539
Plasmodium falciparum plasmepsin IX 0.004 0.0347 0.1893
Onchocerca volvulus Cell death protein 3 homolog 0.0033 0.0241 0.084
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0198 0.2704 0.4041
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0046 0.0434 0.0379
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.0376 0.5366 0.5332
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0142 0.0073
Onchocerca volvulus 0.0025 0.0114 0.0375
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0066 0.0736 0.2698
Loa Loa (eye worm) trypsin family protein 0.0027 0.0142 0.0212
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.017
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.0434 0.0498
Loa Loa (eye worm) MH2 domain-containing protein 0.0104 0.13 0.1943
Toxoplasma gondii kringle domain-containing protein 0.0044 0.0398 0.1366
Schistosoma mansoni amine GPCR 0.0046 0.0434 0.0379
Plasmodium vivax amine transporter, putative 0.0028 0.0159 0.0359
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0031 0.0206 0.0384
Onchocerca volvulus 0.0046 0.0434 0.1539
Echinococcus granulosus apoptotic protease activating factor 1 0.0023 0.0092 0.0026
Echinococcus multilocularis neuropeptide FF receptor 2 0.0046 0.0434 0.0364
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0047 0.0452 0.4602
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.017
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0022 0.0072 0.0141
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0027 0.0142 0.0073
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.0434 0.0379
Onchocerca volvulus 0.004 0.0347 0.1225
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0027 0.0142 0.0073
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.0434 0.0364
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0107 0.1344 0.2009
Onchocerca volvulus 0.0027 0.014 0.0469
Schistosoma mansoni hypothetical protein 0.0046 0.0434 0.0379
Loa Loa (eye worm) aspartic protease BmAsp-1 0.004 0.0347 0.0519
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Brugia malayi aspartic protease BmAsp-1, identical 0.004 0.0347 0.0647
Loa Loa (eye worm) hypothetical protein 0.0037 0.0302 0.0451
Schistosoma mansoni growth hormone secretagogue receptor 0.0046 0.0434 0.0379
Brugia malayi hypothetical protein 0.0028 0.0159 0.0296
Onchocerca volvulus 0.0046 0.0434 0.1539
Schistosoma mansoni cathepsin D (A01 family) 0.0277 0.3888 0.4001
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0046 0.0434 0.0364
Echinococcus granulosus neuropeptide s receptor 0.0046 0.0434 0.0498
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Loa Loa (eye worm) hypothetical protein 0.0025 0.0118 0.0176
Echinococcus multilocularis tumor protein p63 0.0114 0.1442 0.1379
Brugia malayi MH2 domain containing protein 0.0104 0.13 0.2423
Brugia malayi exodeoxyribonuclease III family protein 0.0025 0.0115 0.0213
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Brugia malayi Dopamine receptor 0.0046 0.0434 0.0808
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Echinococcus multilocularis glycoprotein Antigen 5 0.004 0.0337 0.0266
Onchocerca volvulus 0.0046 0.0434 0.1539
Schistosoma mansoni neuropeptide receptor 0.0046 0.0434 0.0379
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0434 0.0379
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0165 0.2208 1
Brugia malayi PAN domain containing protein 0.0018 0.0011 0.002
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0107 0.1344 0.1334
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0434 0.0379
Echinococcus granulosus gamma secretase subunit aph 1 0.0056 0.0582 0.0703
Brugia malayi Fibulin-1 precursor 0.0037 0.0302 0.0563
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0022 0.0072 0.0141
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0047 0.0452 0.1615
Brugia malayi Cytochrome P450 family protein 0.0165 0.2208 0.4115
Echinococcus granulosus serotonin receptor 0.0046 0.0434 0.0498
Schistosoma mansoni cytochrome P450 0.0047 0.0452 0.0398
Toxoplasma gondii hypothetical protein 0.0028 0.0159 0.0522
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0028 0.0159 0.009
Echinococcus multilocularis fmrfamide receptor 0.0046 0.0434 0.0364
Schistosoma mansoni hypothetical protein 0.0046 0.0434 0.0379
Onchocerca volvulus 0.0028 0.0159 0.0539
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.002 0.0038 0.0105
Onchocerca volvulus 0.0156 0.2076 0.7515
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0046 0.0434 0.0379
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0046 0.0434 0.0808
Loa Loa (eye worm) hypothetical protein 0.0033 0.0241 0.0361
Loa Loa (eye worm) hypothetical protein 0.0039 0.0322 0.0481
Echinococcus granulosus carboxylesterase 5A 0.0147 0.1939 0.2572
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0142 0.0073
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.0434 0.0648
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0025 0.0115 0.039
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Echinococcus granulosus glycoprotein Antigen 5 0.004 0.0337 0.0364
Echinococcus granulosus 7TM GPCR rhodopsin 0.0046 0.0434 0.0498
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0047 0.0452 0.4602
Schistosoma mansoni acetylcholinesterase 0.0025 0.0114 0.0043
Loa Loa (eye worm) TYRA-2 protein 0.0046 0.0434 0.0648
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0047 0.0452 0.1615
Brugia malayi PAN domain containing protein 0.0018 0.0011 0.002
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0046 0.0434 0.0648
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0434 0.0364
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0047 0.0452 0.4602
Brugia malayi follicle stimulating hormone receptor 0.0046 0.0434 0.0808
Loa Loa (eye worm) hypothetical protein 0.0164 0.2193 0.3278
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.014 0.1842 0.6803
Loa Loa (eye worm) hypothetical protein 0.0028 0.0159 0.0237
Schistosoma mansoni microtubule-associated protein tau 0.0507 0.733 0.7611
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0046 0.0434 0.0648
Echinococcus multilocularis acetylcholinesterase 0.0147 0.1939 0.188
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0028 0.0159 0.0119
Schistosoma mansoni gamma-secretase subunit aph-1 0.0056 0.0582 0.0535
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0106 0.1321 0.1974
Brugia malayi Carboxylesterase family protein 0.0147 0.1939 0.3613
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Loa Loa (eye worm) transcription factor IIA 0.0037 0.0298 0.0445
Echinococcus granulosus transmembrane protease serine 3 0.0027 0.0142 0.0095
Schistosoma mansoni opsin-like receptor 0.0046 0.0434 0.0379
Plasmodium vivax aspartyl proteinase, putative 0.004 0.0347 0.1893
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0434 0.0498
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Brugia malayi hypothetical protein 0.0046 0.0434 0.0808
Echinococcus multilocularis BC026374 protein (S09 family) 0.0025 0.0114 0.0042
Loa Loa (eye worm) acetylcholinesterase 1 0.0147 0.1939 0.2898
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Brugia malayi RE15519p 0.0046 0.0434 0.0808
Onchocerca volvulus 0.0046 0.0434 0.1539
Echinococcus multilocularis neuroligin 0.0025 0.0114 0.0042
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0066 0.0736 0.2628
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0025 0.0115 0.0299
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0046 0.0434 0.0808
Leishmania major cytochrome p450-like protein 0.0047 0.0452 0.1563
Plasmodium vivax polyprenol reductase, putative 0.0027 0.014 0.0204
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0037 0.0302 0.0563
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0047 0.0452 0.1563
Trypanosoma brucei Aph-1 protein, putative 0.0022 0.007 0.0131
Schistosoma mansoni hypothetical protein 0.0249 0.3467 0.3559
Echinococcus granulosus laminin 0.0037 0.0302 0.0316
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0027 0.014 0.0068
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0047 0.0452 0.4602
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0434 0.0498
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0025 0.0115 0.0171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0434 0.0364
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0047 0.0452 0.1615
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.0434 0.0364
Plasmodium falciparum plasmepsin VII 0.004 0.0347 0.1893
Brugia malayi Cell death protein 3 precursor 0.0033 0.0241 0.045
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Schistosoma mansoni neuropeptide receptor 0.0046 0.0434 0.0379
Toxoplasma gondii PAN domain-containing protein 0.0207 0.2844 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0047 0.0452 0.4602
Trypanosoma brucei C-8 sterol isomerase, putative 0.0198 0.2704 1
Schistosoma mansoni hypothetical protein 0.0106 0.1321 0.1309
Loa Loa (eye worm) cytochrome P450 family protein 0.0165 0.2208 0.33
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.017
Echinococcus granulosus acetylcholinesterase 0.0147 0.1939 0.2572
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.017
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0024 0.0102 0.0345
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.002 0.0038 0.0105
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0028 0.0159 0.009
Brugia malayi Kringle domain containing protein 0.0044 0.0398 0.0741
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.0434 0.0364
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0046 0.0434 0.0648
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.004 0.0347 0.0288
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0027 0.014 0.026
Loa Loa (eye worm) hypothetical protein 0.0027 0.0142 0.0212
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0434 0.0379
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0016
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0046 0.0434 0.0364
Brugia malayi Trypsin family protein 0.0027 0.0142 0.0264
Schistosoma mansoni amine GPCR 0.0046 0.0434 0.0379
Brugia malayi neuropeptide F receptor 0.0046 0.0434 0.0808
Schistosoma mansoni myosin xvIII 0.0046 0.0434 0.0379
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0434 0.0379
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0028 0.0159 0.009
Brugia malayi Tachykinin-like peptides receptor 99D 0.0046 0.0434 0.0808
Onchocerca volvulus 0.0046 0.0434 0.1539
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.0376 0.5366 0.5551
Brugia malayi aspartic protease BmAsp-2, identical 0.004 0.0347 0.0647
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0047 0.0452 0.1642
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.0434 0.0364
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0027 0.014 0.0528
Loa Loa (eye worm) hypothetical protein 0.0037 0.0302 0.0451
Schistosoma mansoni alpha-1 adrenergic receptor 0.0046 0.0434 0.0379
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0025 0.0114 0.0043
Brugia malayi hypothetical protein 0.0046 0.0434 0.0808
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0022 0.0072 0.0234
Toxoplasma gondii aspartyl protease 0.004 0.0347 0.1188
Schistosoma mansoni hypothetical protein 0.0027 0.0142 0.0073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0016
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0047 0.0452 0.1615
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0044 0.0398 0.2303
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0025 0.0114 0.0057
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Loa Loa (eye worm) solute carrier family 6 member 4 0.0164 0.2193 0.3278
Onchocerca volvulus 0.0027 0.0142 0.0477
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0046 0.0434 0.0364
Trichomonas vaginalis ap endonuclease, putative 0.0025 0.0115 0.0332
Plasmodium falciparum plasmepsin III 0.004 0.0347 0.1893
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.0434 0.0648
Onchocerca volvulus 0.0046 0.0434 0.1539
Loa Loa (eye worm) hypothetical protein 0.0376 0.5366 0.802
Loa Loa (eye worm) hypothetical protein 0.0027 0.014 0.0209
Echinococcus multilocularis survival motor neuron protein 1 0.0152 0.2014 0.1956
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0047 0.0452 0.1615
Plasmodium vivax aspartyl proteinase, putative 0.0107 0.1344 1
Plasmodium vivax aspartyl protease, putative 0.004 0.0347 0.1893
Brugia malayi PAN domain containing protein 0.0018 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0164 0.2193 0.3278
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0025 0.0115 0.6275
Echinococcus multilocularis 0.0047 0.0452 0.0382
Echinococcus granulosus para nitrobenzyl esterase 0.0025 0.0114 0.0057
Onchocerca volvulus 0.0046 0.0434 0.1539
Brugia malayi RNA, U transporter 1 0.0028 0.0163 0.0304
Onchocerca volvulus 0.0183 0.2475 0.8967
Schistosoma mansoni sodium/chloride dependent transporter 0.0028 0.0159 0.009
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0025 0.0115 0.5
Trypanosoma brucei cytochrome P450, putative 0.0165 0.2208 0.8142
Echinococcus multilocularis somatostatin receptor 0.0046 0.0434 0.0364
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.004 0.0347 0.0288
Echinococcus granulosus fmrfamide receptor 0.0046 0.0434 0.0498
Brugia malayi hypothetical protein 0.0046 0.0434 0.0808
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0016
Loa Loa (eye worm) PAN domain-containing protein 0.0018 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0147 0.1939 0.2898
Echinococcus multilocularis tfiia large subunit 0.0037 0.0298 0.0227
Entamoeba histolytica hypothetical protein 0.0027 0.014 1
Plasmodium vivax plasmepsin IV, putative 0.0107 0.1344 1
Echinococcus multilocularis g-protein coupled receptor 0.0046 0.0434 0.0364
Echinococcus granulosus Mastin 0.004 0.0337 0.0364
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.004 0.0347 0.0288
Loa Loa (eye worm) PAN domain-containing protein 0.0018 0.0011 0.0016
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0324 0.4596 0.4556
Loa Loa (eye worm) hypothetical protein 0.0037 0.0302 0.0451
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.0434 0.0498
Loa Loa (eye worm) hypothetical protein 0.004 0.0347 0.0519
Echinococcus multilocularis Mastin 0.004 0.0337 0.0266
Brugia malayi neuropeptide F receptor 0.0046 0.0434 0.0808
Loa Loa (eye worm) hypothetical protein 0.0046 0.0434 0.0648
Onchocerca volvulus 0.004 0.0347 0.1225
Onchocerca volvulus Arrow homolog 0.0037 0.0302 0.106
Schistosoma mansoni hypothetical protein 0.0046 0.0434 0.0379
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.0434 0.0648
Echinococcus multilocularis G protein coupled receptor 139 0.0046 0.0434 0.0364
Echinococcus granulosus BC026374 protein S09 family 0.0025 0.0114 0.0057
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0035 0.0094
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0028 0.0159 0.0296
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0046 0.0434 0.0498
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0434 0.0498
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0046 0.0434 0.0379
Loa Loa (eye worm) carboxylesterase 0.0025 0.0114 0.017
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0027 0.014 0.0393
Leishmania major C-8 sterol isomerase-like protein 0.0198 0.2704 1
Echinococcus multilocularis neuropeptide receptor 0.0046 0.0434 0.0364
Onchocerca volvulus 0.0027 0.0142 0.0477
Echinococcus multilocularis laminin 0.0037 0.0302 0.0231

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0828 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.2936 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.122 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 1.4125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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