Detailed information for compound 1376923

Basic information

Technical information
  • TDR Targets ID: 1376923
  • Name: 2-methoxy-8-(4-methoxyphenyl)-6-(2-phenylethy l)pteridin-7-one
  • MW: 388.419 | Formula: C22H20N4O3
  • H donors: 0 H acceptors: 3 LogP: 3.21 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ncc2c(n1)n(c1ccc(cc1)OC)c(=O)c(n2)CCc1ccccc1
  • InChi: 1S/C22H20N4O3/c1-28-17-11-9-16(10-12-17)26-20-19(14-23-22(25-20)29-2)24-18(21(26)27)13-8-15-6-4-3-5-7-15/h3-7,9-12,14H,8,13H2,1-2H3
  • InChiKey: JEURQJHCDAVPKS-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-methoxy-8-(4-methoxyphenyl)-6-(2-phenylethyl)-7-pteridinone
  • NCGC00011414
  • PCOP-478235

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0033 0.014 0.1814
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.0954 0.0973
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0268 0.1231
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0021 0.0052 0.0053
Brugia malayi Matrixin family protein 0.0165 0.1103 0.5061
Loa Loa (eye worm) acetyltransferase 0.0144 0.0954 0.4378
Mycobacterium tuberculosis Probable fumarate reductase [flavoprotein subunit] FrdA (fumarate dehydrogenase) (fumaric hydrogenase) 0.0021 0.0049 0.0051
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0021 0.0052 0.0026
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0268 0.0274
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0042 0.0191
Echinococcus multilocularis protein patched 0.0041 0.0195 0.0199
Echinococcus multilocularis caspase 8 0.0044 0.0216 0.022
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0234 0.0238
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0312 0.0318
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0016 0.0016
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0033 0.014 0.0686
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.039 0.1787
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0042 0.0042
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0038 0.0039
Trypanosoma cruzi metacaspase, putative 0.0044 0.0216 0.1059
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0193 0.0947
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0044 0.0216 0.2869
Echinococcus granulosus hypothetical protein 0.0026 0.0088 0.009
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0021 0.0052 0.0026
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0102 0.064 0.0662
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0152 0.0371
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0234 0.0238
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.0954 0.0973
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0911 0.4461
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0021 0.0051 0.1692
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0042 0.0037
Loa Loa (eye worm) hypothetical protein 0.005 0.026 0.1191
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0009 0.004
Schistosoma mansoni succinate dehydrogenase iron-sulfur protein 0.0027 0.0096 0.0098
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0152 0.0303
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0163 0.0331
Onchocerca volvulus Matrilysin homolog 0.0068 0.0395 0.3694
Echinococcus multilocularis tumor protein p63 0.0335 0.235 0.2395
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0191
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0594 0.1452
Echinococcus multilocularis CREB binding protein 0.0016 0.0016 0.0016
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.2041 1
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0268 0.0274
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) 0.1332 0.9667 1
Schistosoma mansoni lipoxygenase 0.002 0.0038 0.0039
Schistosoma mansoni hypothetical protein 0.0801 0.5773 0.5884
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.4095 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0088 0.0402
Leishmania major hypothetical protein, conserved 0.0016 0.0009 0.0043
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0021 0.0052 0.0026
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0042 0.0042
Loa Loa (eye worm) inositol-1 0.0037 0.0163 0.0749
Loa Loa (eye worm) hypothetical protein 0.0048 0.0244 0.112
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0052 0.0253
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0042 0.0042
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0163 0.0331
Schistosoma mansoni succinate dehydrogenase 0.0021 0.0049 0.005
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0009 0.0009
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0028 0.0029
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0074 0.0438 0.2144
Echinococcus granulosus caspase 3 0.0072 0.0423 0.0431
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0009 0.0009
Trypanosoma cruzi ISWI complex protein 0.0015 0.0004 0.0017
Brugia malayi MAP kinase sur-1 0.0051 0.0268 0.1231
Echinococcus granulosus CREB binding protein 0.0016 0.0016 0.0016
Trypanosoma cruzi ISWI complex protein 0.0015 0.0004 0.0017
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.003 0.0117 0.0572
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0025 0.0026
Trypanosoma brucei Metacaspase-4 0.0044 0.0216 0.1059
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0021 0.0052 0.0053
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0021 0.0052 0.0026
Loa Loa (eye worm) hypothetical protein 0.0049 0.0254 0.1166
Trichomonas vaginalis STE family protein kinase 0.0074 0.0438 0.1006
Echinococcus granulosus dual specificity mitogen activated protein 0.0074 0.0438 0.0446
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0021 0.0052 0.0026
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0074 0.0438 0.2007
Mycobacterium leprae N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) 0.0045 0.0228 0.018
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0172 0.0354
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0042 0.0191
Onchocerca volvulus 0.0068 0.0395 0.3694
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0045 0.0228 0.3036
Plasmodium vivax iron-sulfur subunit of succinate dehydrogenase, putative 0.005 0.0259 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0102 0.064 0.0662
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0098 0.1238
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0048 0.0244 0.0249
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0051 0.0251
Brugia malayi Thioredoxin reductase 0.0045 0.0227 0.1041
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0033 0.014 0.0143
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0042 0.0191
Trypanosoma brucei cytochrome P450, putative 0.0032 0.0129 0.0633
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0092 0.0571 0.0591
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0042 0.0191
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0152 0.1977
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0045 0.0228 0.8761
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0721 0.0745
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.4095 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0268 0.1315
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0021 0.0051 0.0251
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0268 0.0274
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0042 0.0042
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0268 0.1315
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0021 0.0052 0.0026
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0163 0.08
Mycobacterium tuberculosis N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) 0.0045 0.0228 0.0236
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0284 0.1301
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0197 0.0963
Trypanosoma cruzi metacaspase 5, putative 0.0044 0.0216 0.1059
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0098 0.0451
Trypanosoma cruzi trypanothione reductase, putative 0.0021 0.0051 0.0251
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0033 0.014 0.0342
Mycobacterium leprae putative cytochrome p450 0.0021 0.0052 0.0002
Schistosoma mansoni succinate dehydrogenase iron-sulfur protein 0.005 0.0259 0.0264
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0028 0.0131
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0068 0.0395 0.181
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0046 0.0047
Leishmania major NADH dehydrogenase, putative 0.0032 0.0132 0.0648
Loa Loa (eye worm) hypothetical protein 0.0068 0.0395 0.181
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0045 0.0228 0.0491
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0163 0.0138
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0051 0.0251
Echinococcus multilocularis succinate dehydrogenase (ubiquinone) 0.0021 0.0049 0.005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0042 0.0042
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0033 0.014 0.0686
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0193 0.0947
Brugia malayi Bromodomain containing protein 0.0042 0.0205 0.0941
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0045 0.0228 0.1047
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0033 0.014 0.0274
Schistosoma mansoni hypothetical protein 0.0039 0.0184 0.0188
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0074 0.0438 0.2144
Brugia malayi succinate dehydrogenase [ubiquinone] iron-sulfur protein, mitochondrial 0.005 0.0259 0.119
Brugia malayi Cell death protein 3 precursor 0.0085 0.0516 0.2365
Trypanosoma cruzi trypanothione reductase, putative 0.0045 0.0227 0.1111
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0023 0.0103
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0281 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0244 0.053
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0163 0.0331
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0042 0.0191
Leishmania major eukaryotic translation initiation factor-like protein 0.0033 0.014 0.0686
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0116 0.0745 0.0759
Schistosoma mansoni DNA helicase recq5 0.0028 0.0098 0.01
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0193 0.0947
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0045 0.0228 0.0557
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0045 0.0228 0.0233
Echinococcus granulosus neuropeptide s receptor 0.045 0.3195 0.3256
Echinococcus granulosus tumor protein p63 0.0335 0.235 0.2395
Brugia malayi hypothetical protein 0.002 0.0038 0.0175
Onchocerca volvulus 0.0049 0.0254 0.2238
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0193 0.0947
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0268 0.059
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0021 0.0052 0.0053
Giardia lamblia Kinase, STE STE20 0.0074 0.0438 0.1006
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0106 0.0673 0.0686
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0042 0.0191
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0152 0.0303
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0032 0.0129 0.0104
Schistosoma mansoni inositol monophosphatase 0.0037 0.0163 0.0166
Echinococcus granulosus dna polymerase kappa 0.0041 0.0193 0.0197
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0028 0.014
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0175
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0021 0.0052 0.0053
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0021 0.0051 0.0251
Toxoplasma gondii NADPH-glutathione reductase 0.0021 0.0051 0.0586
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0048 0.0244 0.0249
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0028 0.014
Echinococcus granulosus ubiquitin specific protease 41 0.0048 0.0244 0.0249
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0191
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0721 0.0675
Schistosoma mansoni hypothetical protein 0.0039 0.0184 0.0188
Echinococcus multilocularis CREB binding protein 0.0075 0.0442 0.045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.4095 1
Brugia malayi jmjC domain containing protein 0.0016 0.0009 0.004
Trypanosoma cruzi Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0.0021 0.0049 0.0241
Mycobacterium tuberculosis Probable reductase 0.0092 0.0571 0.0591
Plasmodium falciparum thioredoxin reductase 0.0045 0.0227 0.8703
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0021 0.0051 0.0053
Schistosoma mansoni cytochrome P450 0.0021 0.0052 0.0053
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0152 0.0696
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0038 0.1169
Onchocerca volvulus 0.0041 0.0194 0.1617
Loa Loa (eye worm) matrixin family protein 0.0165 0.1103 0.5061
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.0098 0.0451
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0193 0.0947
Schistosoma mansoni microtubule-associated protein tau 0.1352 0.9812 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0045 0.0228 0.0236
Brugia malayi Doublecortin family protein 0.002 0.0038 0.0175
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0033 0.014 0.0686
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0033 0.014 0.0143
Schistosoma mansoni hypothetical protein 0.0026 0.0088 0.009
Echinococcus granulosus zinc finger protein 0.0027 0.0096 0.0097
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0042 0.0042
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0359 0.1648
Mycobacterium ulcerans hydrolase 0.0083 0.0504 0.0479
Echinococcus granulosus neuropeptide receptor A26 0.045 0.3195 0.3256
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0021 0.0051 0.0251
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0042 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0193 0.0947
Brugia malayi glutathione reductase 0.0045 0.0227 0.1041
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0216 0.0462
Brugia malayi jmjC domain containing protein 0.0063 0.0359 0.1648
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0172 0.6533
Trypanosoma brucei trypanothione reductase 0.0045 0.0227 0.1111
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.2041 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0042 0.0042
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0037 0.0169 0.639
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0152 0.0743
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0079 0.008
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1053 0.1073
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0042 0.0042
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0021 0.0051 0.1692
Echinococcus multilocularis protein dispatched 1 0.0047 0.0237 0.0242
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0119 0.077 0.0785
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.023 0.0235
Onchocerca volvulus Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial homolog 0.0021 0.0049 0.0114
Plasmodium falciparum iron-sulfur subunit of succinate dehydrogenase 0.005 0.0259 1
Echinococcus granulosus expressed conserved protein 0.009 0.0552 0.0563
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0152 0.0155
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0052 0.0253
Schistosoma mansoni zinc finger protein 0.0015 0.0004 0.0004
Echinococcus granulosus dnaJ subfamily B 0.0801 0.5773 0.5884
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0009 0.0009
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0021 0.0052 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0015 0.0075
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0045 0.0228 0.1047
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0216 0.0462
Schistosoma mansoni alpha-glucosidase 0.0136 0.0891 0.0908
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0042 0.0191
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0227 0.0489
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0028 0.0098 0.0451
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0021 0.0052 0.0053
Echinococcus granulosus caspase 2 0.0085 0.0516 0.0525
Brugia malayi steroid hormone receptor 0.002 0.0042 0.0191
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.1257 0.1282
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0042 0.0037
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0038 0.0039
Entamoeba histolytica recQ family helicase, putative 0.003 0.0117 0.0285
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.0052 0.0253
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0021 0.0051 0.0052
Echinococcus multilocularis RUN 0.002 0.0038 0.0039
Echinococcus multilocularis apoptotic protease activating factor 1 0.0041 0.0194 0.0198
Echinococcus granulosus succinate dehydrogenase (ubiquinone) iron sulfur 0.005 0.0259 0.0264
Schistosoma mansoni hypothetical protein 0.002 0.0041 0.0042
Trichomonas vaginalis STE family protein kinase 0.0074 0.0438 0.1006
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0234 0.2027
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0098 0.0451
Treponema pallidum NADH oxidase 0.0021 0.0051 0.0056
Trypanosoma cruzi metacaspase, putative 0.0044 0.0216 0.1059
Schistosoma mansoni caspase-3 (C14 family) 0.0116 0.0745 0.0759
Loa Loa (eye worm) hypothetical protein 0.0045 0.0222 0.102
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0163 0.0166
Schistosoma mansoni caspase-7 (C14 family) 0.0085 0.0516 0.0525
Onchocerca volvulus 0.0097 0.0604 0.5858
Schistosoma mansoni cpg binding protein 0.0061 0.0345 0.0351
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0021 0.0052 0.0026
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0021 0.0052 0.0053
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0234 0.0238
Onchocerca volvulus 0.0046 0.0234 0.2027
Brugia malayi tumor suppressor. 0.0312 0.218 1
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0145 0.0712
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0046 0.0234 0.0238
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0021 0.0052 0.0026
Schistosoma mansoni lipoxygenase 0.0055 0.0296 0.0302
Loa Loa (eye worm) hypothetical protein 0.005 0.0263 0.1205
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0048 0.0244 0.0596
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0216 0.0462
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0195 0.0199
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0227 0.3024
Echinococcus multilocularis caspase 3 0.0072 0.0423 0.0431
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0193 0.0947
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0268 0.1315
Plasmodium falciparum flavoprotein subunit of succinate dehydrogenase 0.0021 0.0049 0.1609
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0216 0.828
Schistosoma mansoni hypothetical protein 0.0039 0.0184 0.0188
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB 0.0045 0.0228 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0216 0.0462
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0042 0.0191
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0191
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0021 0.0052 0.0026
Plasmodium falciparum thioredoxin reductase 0.0021 0.0051 0.1692
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0045 0.0227 0.0235
Giardia lamblia Fructose-bisphosphate aldolase 0.0573 0.4095 1
Mycobacterium leprae Conserved hypothetical protein 0.0021 0.0052 0.0002
Plasmodium vivax flavoprotein subunit of succinate dehydrogenase, putative 0.0021 0.0049 0.1609
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0042 0.0042
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0048 0.005
Leishmania major cytochrome p450-like protein 0.0032 0.0129 0.0633
Onchocerca volvulus 0.002 0.0042 0.0037
Onchocerca volvulus Matrilysin homolog 0.0151 0.1003 1
Toxoplasma gondii thioredoxin reductase 0.0045 0.0227 0.3016
Loa Loa (eye worm) hypothetical protein 0.0046 0.0234 0.1072
Schistosoma mansoni ap endonuclease 0.0018 0.0028 0.0029
Loa Loa (eye worm) translation initiation factor 4E 0.0033 0.014 0.0642
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0234 0.0238
Mycobacterium ulcerans succinate dehydrogenase flavoprotein subunit 0.0021 0.0049 0.0024
Brugia malayi mbt repeat family protein 0.0046 0.0234 0.1072
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0193 0.0405
Schistosoma mansoni rab6-interacting 0.002 0.0038 0.0039
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0042 0.0042
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.1053 0.4828
Schistosoma mansoni zinc finger protein 0.0027 0.0096 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0015 0.0075
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0045 0.0228 0.1119
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0197 0.0963
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0092 0.0571 0.0591
Trypanosoma brucei metacaspase 5, putative 0.0044 0.0216 0.1059
Schistosoma mansoni hypothetical protein 0.0097 0.0604 0.0615
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0336 0.1646
Echinococcus multilocularis protein quaking 0.0026 0.0088 0.009
Mycobacterium tuberculosis Probable oxidoreductase 0.0102 0.064 0.0662
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0381 0.0388
Schistosoma mansoni polycystin 1-related 0.002 0.0038 0.0039
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.023 0.0235
Echinococcus granulosus phd:f box containing protein 0.0016 0.0009 0.0009
Brugia malayi hypothetical protein 0.002 0.0038 0.0175
Loa Loa (eye worm) hypothetical protein 0.0083 0.0504 0.231
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0048 0.0244 0.053
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0051 0.0251
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0042 0.0191
Brugia malayi Matrixin family protein 0.0068 0.0395 0.181
Echinococcus multilocularis dnaJ subfamily B 0.0801 0.5773 0.5884
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0042 0.0042
Mycobacterium leprae Probable succinate dehydrogenase (iron-sulfur protein subunit) SdhB (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHY 0.0027 0.0096 0.0048
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0021 0.0051 0.0026
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0021 0.0052 0.0026
Leishmania major hypothetical protein, conserved 0.0015 0.0004 0.0017
Plasmodium vivax thioredoxin reductase, putative 0.0045 0.0227 0.8703
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.0084 0.0085
Echinococcus granulosus RUN 0.002 0.0038 0.0039
Echinococcus granulosus protein quaking 0.0026 0.0088 0.009
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0021 0.0052 0.0053
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0021 0.0051 0.0235
Echinococcus multilocularis bloom syndrome protein 0.004 0.0187 0.0191
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.0052 0.0253
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0033 0.014 0.0274
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0216 0.0462
Trypanosoma cruzi succinate dehydrogenase, putative 0.0032 0.0129 0.063
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0268 0.3591
Loa Loa (eye worm) tumor suppressor 0.0312 0.218 1
Brugia malayi nuclear hormone receptor 0.002 0.0042 0.0191
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0048 0.0244 0.053
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0336 0.0342
Echinococcus multilocularis succinate dehydrogenase iron sulfur protein 0.0027 0.0096 0.0098
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0163 0.0398
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0191
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0227 0.0232
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0051 0.0251
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0045 0.0228 0.1119
Mycobacterium tuberculosis Probable fumarate reductase [iron-sulfur subunit] FrdB (fumarate dehydrogenase) (fumaric hydrogenase) 0.0027 0.0096 0.01
Loa Loa (eye worm) hypothetical protein 0.0037 0.0167 0.0768
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0048 0.0244 0.0249
Trypanosoma brucei succinate dehydrogenase iron-sulfur subunit 0.0027 0.0096 0.0473
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0268 0.0274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0042 0.0191
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0308 0.1411
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0296 0.0302
Schistosoma mansoni protein kinase 0.0074 0.0438 0.0446
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0042 0.0191
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0048 0.0244 0.0249
Brugia malayi jmjC domain containing protein 0.0016 0.0009 0.004
Schistosoma mansoni hypothetical protein 0.0041 0.0194 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0193 0.0947
Brugia malayi hypothetical protein 0.0041 0.0194 0.0891
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0312 0.0287
Echinococcus multilocularis CREB binding protein 0.0016 0.0016 0.0016
Brugia malayi succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0.0021 0.0049 0.0225
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0042 0.0042
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0721 0.0745
Giardia lamblia NADH oxidase lateral transfer candidate 0.0021 0.0051 0.0056
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0116 0.0745 0.0759
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.0098 0.01
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0195 0.0199
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.0098 0.01
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0216 0.0462
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0045 0.0228 0.0491
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0074 0.0438 0.2007
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0895 0.0912
Trypanosoma cruzi metacaspase, putative 0.0044 0.0216 0.1059
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0079 0.008
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0268 0.059
Brugia malayi Temporarily assigned gene name protein 44 0.0026 0.0088 0.0405
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0042 0.0191
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0032 0.0132 0.1707
Trichomonas vaginalis DNA helicase recq1, putative 0.004 0.0187 0.0391
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0051 0.0251
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.1053 0.4828
Brugia malayi Bloom's syndrome protein homolog 0.004 0.0187 0.0859
Treponema pallidum fructose-bisphosphate aldolase 0.0573 0.4095 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0021 0.0052 0.0026
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0021 0.0052 0.0053
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0594 0.0606
Leishmania major cytochrome p450-like protein 0.0021 0.0052 0.0253
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0268 0.059
Echinococcus multilocularis 0.0021 0.0052 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0042 0.0191
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0381 0.0388
Echinococcus granulosus succinate dehydrogenase ubiquinone 0.0021 0.0049 0.005
Schistosoma mansoni inositol monophosphatase 0.0037 0.0163 0.0166
Schistosoma mansoni thyroid hormone receptor 0.002 0.0042 0.0042
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0021 0.0051 0.0052
Echinococcus multilocularis neuropeptide s receptor 0.045 0.3195 0.3256
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0032 0.0132 0.4926
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0042 0.0191
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.0359 0.0366
Brugia malayi nuclear receptor NHR-88 0.002 0.0042 0.0191
Schistosoma mansoni cpg binding protein 0.0061 0.0345 0.0351
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0135 0.0086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0051 0.0251
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0135 0.014
Schistosoma mansoni nuclear hormone receptor 0.002 0.0042 0.0042
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0021 0.0052 0.0026
Brugia malayi jmjC domain containing protein 0.0016 0.0009 0.004
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0021 0.0052 0.0026
Chlamydia trachomatis succinate dehydrogenase iron sulfur subunit 0.0027 0.0096 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.0052 0.0253
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0021 0.0051 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0193 0.0947
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0152 0.0696
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0016 0.0016
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0021 0.0052 0.0026
Loa Loa (eye worm) RecQ helicase 0.004 0.0187 0.0859
Schistosoma mansoni DNA helicase recq1 0.0028 0.0098 0.01
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0051 0.0251
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0051 0.0251
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0193 0.0947
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0042 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0048 0.0235
Trichomonas vaginalis glutathione reductase, putative 0.0021 0.0051 0.0056
Echinococcus granulosus caspase 0.0116 0.0745 0.0759
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0193 0.0168
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0129 0.0633
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0038 0.0039
Trypanosoma cruzi NADH dehydrogenase, putative 0.0032 0.0132 0.0648
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0109
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0048 0.0244 0.0249
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0281 0.0286
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0152 0.0303
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0216 0.0462
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0068 0.0395 0.0402
Brugia malayi ecdysteroid receptor 0.002 0.0042 0.0191
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0152 0.0303
Brugia malayi Cytochrome P450 family protein 0.0032 0.0129 0.0593
Mycobacterium tuberculosis Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) 0.0021 0.0049 0.0051
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0254 0.0259
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0193 0.0947
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0197 0.0963
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0051 0.0251
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0028 0.0786
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0021 0.0052 0.0026
Loa Loa (eye worm) succinate dehydrogenase iron-sulfur protein 0.005 0.0259 0.119
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0895 0.0912
Schistosoma mansoni caspase-7 (C14 family) 0.0116 0.0745 0.0759
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0152 0.0303
Brugia malayi hypothetical protein 0.0026 0.0088 0.0405
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.0911 0.4461
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.028 0.1947 0.1907
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.1053 0.1073
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0021 0.0051 0.0052
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0079 0.008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0042 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0216 0.0462
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.0098 0.01
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0083 0.0504 0.231
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0193 0.0947
Schistosoma mansoni hypothetical protein 0.0021 0.0052 0.0053
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.2041 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0102 0.064 0.0593
Trypanosoma cruzi metacaspase 5, putative 0.0044 0.0216 0.1059
Schistosoma mansoni thyroid hormone receptor 0.002 0.0042 0.0042
Trypanosoma brucei ISWI complex protein 0.0015 0.0004 0.0017
Loa Loa (eye worm) matrix metalloproteinase 0.0068 0.0395 0.181
Mycobacterium ulcerans succinate dehydrogenase iron-sulfur subunit 0.0027 0.0096 0.0071
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0045 0.0228 0.0233
Schistosoma mansoni alpha-glucosidase 0.0136 0.0891 0.0908
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0009 0.0043
Echinococcus multilocularis CREB binding protein 0.0016 0.0016 0.0016
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0227 0.0489
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0009 0.0009
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0016 0.0016
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.0896 0.0913
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0015 0.0075
Schistosoma mansoni ap endonuclease 0.0018 0.0028 0.0029
Trypanosoma cruzi succinate dehydrogenase iron-sulfur subunit 0.0027 0.0096 0.0473
Brugia malayi mbt repeat family protein 0.0046 0.0234 0.1072
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0152 0.0303
Plasmodium vivax metacaspase 1, putative 0.0044 0.0216 0.828
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0028 0.0131
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0152 0.0743
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0193 0.0168
Toxoplasma gondii succinate dehydrogenase [ubiquinone] iron-sulfur protein 0.005 0.0259 0.3466
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0033 0.014 0.0143
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0163 0.08
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.4095 1
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0038 0.1169
Mycobacterium leprae PROBABLE HYDROLASE 0.0083 0.0504 0.0457
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0051 0.0251
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0234 0.0238
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0281 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0195 0.041
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0042 0.0042
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0021 0.0052 0.0053
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0234 0.1072
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0028 0.007
Toxoplasma gondii hypothetical protein 0.0047 0.0241 0.3212
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0009 0.0009
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0216 0.0462
Loa Loa (eye worm) doublecortin family protein 0.002 0.0038 0.0175
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0051 0.0251
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.0244 0.1196
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0121 0.0591
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0042 0.0191
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0193 0.0947
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0016 0.0016
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.028 0.1947 0.1926
Schistosoma mansoni rab6-interacting 0.002 0.0038 0.0039
Trypanosoma cruzi succinate dehydrogenase iron-sulfur subunit 0.0032 0.0129 0.063
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0044 0.0216 0.2869
Echinococcus multilocularis succinate dehydrogenase (ubiquinone) iron sulfur 0.005 0.0259 0.0264
Plasmodium vivax glutathione reductase, putative 0.0045 0.0227 0.8703
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.015 0.0153
Loa Loa (eye worm) hypothetical protein 0.0031 0.0121 0.0554
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0021 0.0051 0.0251
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0046 0.0047
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0216 0.0462
Brugia malayi Matrixin family protein 0.0068 0.0395 0.181
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0163 0.0166
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0282 0.1963 0.9006
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.0244 0.1196
Schistosoma mansoni patched 1 0.0041 0.0195 0.0199
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0195 0.0199
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0033 0.014 0.0274
Schistosoma mansoni CREB-binding protein 2 0.0106 0.0673 0.0686
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0021 0.0052 0.0053
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0042 0.0037
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0312 0.1527
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0051 0.0984
Trichomonas vaginalis DNA helicase recq, putative 0.004 0.0187 0.0391
Echinococcus granulosus CREB binding protein 0.0016 0.0016 0.0016
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0216 0.0462
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0033 0.014 0.0342
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0023 0.0023
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0268 0.1315
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0021 0.0051 0.1692
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.4095 1
Schistosoma mansoni hypothetical protein 0.0026 0.0088 0.009
Echinococcus multilocularis cpg binding protein 0.0061 0.0345 0.0351
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0032 0.0132 0.4926
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0059 0.0268
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0051 0.0984
Loa Loa (eye worm) hypothetical protein 0.0053 0.0281 0.1288
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0163 0.2136
Schistosoma mansoni cpg binding protein 0.0056 0.0308 0.0313
Brugia malayi jmjC domain containing protein 0.0058 0.0322 0.1478
Loa Loa (eye worm) cytochrome P450 0.0021 0.0052 0.0237
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0152 0.0155
Echinococcus multilocularis caspase 0.0116 0.0745 0.0759
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0268 0.1315
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0021 0.0052 0.0053
Mycobacterium tuberculosis Probable succinate dehydrogenase (iron-sulphur protein subunit) SdhB (succinic dehydrogenase) (fumarate reductase) (fumarate deh 0.0027 0.0096 0.01
Trypanosoma brucei metacaspase 0.0044 0.0216 0.1059
Brugia malayi Hemopexin family protein 0.0097 0.0604 0.2769
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0034 0.0158
Toxoplasma gondii flavoprotein subunit of succinate dehydrogenase 0.0021 0.0049 0.0558
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0191
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0009 0.004
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0028 0.0786
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0074 0.0438 0.2144
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0028 0.014
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0172 0.0421
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0152 0.0371
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.1025 0.1061
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0268 0.1315
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0605 0.0617
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0048 0.0235
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0359 0.0366
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0175
Plasmodium falciparum glutathione reductase 0.0045 0.0227 0.8703
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0025 0.0026
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0227 0.3024
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0268 0.1315
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0191
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0268 0.059
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0045 0.0228 0.0557
Brugia malayi Bromodomain containing protein 0.0081 0.0489 0.2245
Brugia malayi polk-prov protein 0.0031 0.0121 0.0554
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.028 0.1947 0.2014
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.0244 0.1196
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0033 0.014 0.0686
Echinococcus granulosus CREB binding protein 0.0068 0.0391 0.0399
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0296 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0042 0.0191
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0268 0.0274
Trypanosoma brucei glucosidase, putative 0.0035 0.0152 0.0743
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.0052 0.0053
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0021 0.0052 0.0053
Brugia malayi CXXC zinc finger family protein 0.0056 0.0308 0.1411
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1053 0.1073
Schistosoma mansoni hypothetical protein 0.0285 0.1982 0.202
Trypanosoma brucei Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0.0021 0.0049 0.0241
Echinococcus multilocularis succinate dehydrogenase (ubiquinone) iron sulfur 0.0032 0.0129 0.0131
Brugia malayi Cytochrome P450 family protein 0.0067 0.039 0.1787
Plasmodium falciparum metacaspase-like protein 0.0044 0.0216 0.828
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0268 0.059
Trypanosoma cruzi NADH dehydrogenase, putative 0.0032 0.0132 0.0648
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.003 0.0117 0.0572
Trichomonas vaginalis DNA helicase recq, putative 0.003 0.0117 0.0217
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0038 0.0039
Leishmania major hypothetical protein, conserved 0.0027 0.0096 0.0473
Toxoplasma gondii exonuclease III APE 0.0018 0.0028 0.0272
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0009 0.0043
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0195 0.0895
Echinococcus granulosus bloom syndrome protein 0.004 0.0187 0.0191
Leishmania major DNA polymerase kappa, putative 0.0021 0.0048 0.0235
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0028 0.0029
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0009 0.004
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0042 0.0191
Mycobacterium tuberculosis Probable succinate dehydrogenase (flavoprotein subunit) SdhA (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogena 0.0021 0.0049 0.0051
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.0098 0.0172
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0042 0.0042
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0129 0.0593
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.1257 0.1282
Loa Loa (eye worm) hypothetical protein 0.0095 0.0594 0.2727
Mycobacterium ulcerans succinate dehydrogenase flavoprotein subunit 0.0021 0.0049 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.4095 1
Trichomonas vaginalis mercuric reductase, putative 0.0021 0.0051 0.0056
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0041 0.019
Plasmodium falciparum glutathione reductase 0.0021 0.0051 0.1692
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0312 0.143
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0216 0.0462
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0193 0.0405
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.1378 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0129 0.0633
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0025 0.0026
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0115
Brugia malayi follicle stimulating hormone receptor 0.0282 0.1963 0.9006
Onchocerca volvulus 0.0056 0.0308 0.2792
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0021 0.0051 0.0026
Schistosoma mansoni coup transcription factor 0.002 0.0042 0.0042
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0048 0.0244 0.1196
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0248 0.1712 0.1745
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0193 0.0197
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0009 0.0009
Trichomonas vaginalis STE family protein kinase 0.0074 0.0438 0.1006
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0152 0.0303
Echinococcus multilocularis zinc finger protein 0.0027 0.0096 0.0097
Trypanosoma brucei NADH dehydrogenase 0.0032 0.0132 0.0648
Loa Loa (eye worm) CBP-B 0.0075 0.0448 0.2057
Trypanosoma brucei succinate dehydrogenase iron-sulfur subunit, putative 0.0032 0.0129 0.063
Brugia malayi jmjC domain containing protein 0.0016 0.0009 0.004
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0216 0.0462
Loa Loa (eye worm) succinate-ubiquinone oxidoreductase 0.0021 0.0049 0.0225
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0191
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0032 0.0132 0.1707
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0336 0.0342
Leishmania major eukaryotic translation initiation factor-like 0.0033 0.014 0.0686
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.0098 0.01
Echinococcus multilocularis ubiquitin specific protease 41 0.0048 0.0244 0.0249
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0021 0.0052 0.0053
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0042 0.0042
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0009 0.0043
Schistosoma mansoni hypothetical protein 0.0015 0.0004 0.0004
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0042 0.0042
Schistosoma mansoni loxhd1 0.002 0.0038 0.0039
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0042 0.0042
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0152 0.0303
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0042 0.0042
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0045 0.0228 0.1119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0042 0.0191
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0033 0.014 0.0274
Loa Loa (eye worm) hypothetical protein 0.0085 0.0516 0.2365
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0193 0.0947
Mycobacterium ulcerans hypothetical protein 0.0154 0.1025 0.1002
Echinococcus granulosus caspase 8 0.0044 0.0216 0.022
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0021 0.0052 0.0026
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0216 0.0462
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0359 0.0366
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0322 0.0328
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.0098 0.3571
Brugia malayi succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0.0021 0.0049 0.0225
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0322 0.0328
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0045 0.0228 0.0233
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.0052 0.0592
Onchocerca volvulus Matrix metalloproteinase homolog 0.0151 0.1003 1
Brugia malayi cytochrome P450 0.0021 0.0052 0.0237
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0021 0.0052 0.0053
Echinococcus granulosus succinate dehydrogenase ubiquinone iron sulfur 0.0022 0.0058 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0042 0.0191
Loa Loa (eye worm) matrixin family protein 0.0151 0.1003 0.4603
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0312 0.0318
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0042 0.0042
Leishmania major cytochrome p450-like protein 0.0021 0.0052 0.0253
Brugia malayi Inositol-1 0.0037 0.0163 0.0749
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0042 0.0042
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0065 0.078
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0048 0.0244 0.112
Trypanosoma brucei unspecified product 0.0034 0.0145 0.0712
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0021 0.0052 0.0026
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0044 0.0216 0.0992
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0042 0.0042
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0051 0.0251
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0009 0.0009
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0129 0.0593
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0152 0.0743
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0336 0.0311
Onchocerca volvulus 0.0091 0.0564 0.5452
Giardia lamblia DINP protein human, muc B family 0.0021 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0992
Wolbachia endosymbiont of Brugia malayi succinate dehydrogenase iron-sulfur subunit 0.005 0.0259 1
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0594 0.0606
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0216 0.0462
Trypanosoma brucei metacaspase MCA3 0.0044 0.0216 0.1059
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0234 0.0238
Echinococcus granulosus FTZ F1 alpha 0.002 0.0042 0.0042
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0336 0.0348
Brugia malayi translation initiation factor 4E 0.0033 0.014 0.0642
Loa Loa (eye worm) glutathione reductase 0.0045 0.0227 0.1041
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0042 0.0191
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0336 0.0311
Brugia malayi CHE-14 protein 0.0041 0.0195 0.0895
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0021 0.0052 0.0053
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0129 0.0593
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0021 0.0052 0.0053
Onchocerca volvulus Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial homolog 0.0021 0.0049 0.0114
Wolbachia endosymbiont of Brugia malayi succinate dehydrogenase flavoprotein subunit 0.0021 0.0049 0.0894
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0048 0.0244 0.0249
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0042 0.0042
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.0069 0.2409
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0234 0.0238
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0312 0.0287
Schistosoma mansoni hypothetical protein 0.0039 0.0184 0.0188
Leishmania major succinate dehydrogenase flavoprotein, putative 0.0021 0.0049 0.0241
Brugia malayi Cytochrome P450 family protein 0.0021 0.0052 0.0237
Mycobacterium tuberculosis Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) 0.0018 0.0026 0.0027
Brugia malayi Cytochrome P450 family protein 0.0032 0.0129 0.0593
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0021 0.0052 0.0053
Loa Loa (eye worm) thioredoxin reductase 0.0045 0.0227 0.1041
Brugia malayi TAZ zinc finger family protein 0.0106 0.0673 0.3089
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0121 0.0591
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0032 0.0132 0.0107
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0281 0.0286
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0028 0.014
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0028 0.0029
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0009 0.0009
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0163 0.08
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0025 0.0026
Loa Loa (eye worm) hypothetical protein 0.0069 0.0397 0.1823
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0322 0.0328
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0594 0.2727
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0573 0.4095 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.4095 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0195 0.0895
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0042 0.0042
Echinococcus multilocularis microtubule associated protein 2 0.1352 0.9812 1
Echinococcus granulosus CREB binding protein 0.0106 0.0673 0.0686
Leishmania major succinate dehydrogenase, putative 0.0032 0.0129 0.063
Echinococcus multilocularis expressed conserved protein 0.009 0.0552 0.0563
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0042 0.0191
Loa Loa (eye worm) MBCTL1 0.0053 0.0281 0.1288
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0281 0.0286
Schistosoma mansoni alpha glucosidase 0.0035 0.0152 0.0155
Loa Loa (eye worm) hypothetical protein 0.0068 0.0395 0.181
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0009 0.0009
Brugia malayi Matrixin family protein 0.0068 0.0395 0.181
Mycobacterium tuberculosis Probable dehydrogenase 0.0092 0.0571 0.0591
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0197 0.0963
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0023 0.0023
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0336 0.0311
Echinococcus multilocularis neuropeptide receptor A26 0.045 0.3195 0.3256
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.003 0.0117 0.0572
Echinococcus granulosus succinate dehydrogenase ubiquinone iron sulfur 0.005 0.0259 0.0264
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0911 0.4461
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0083 0.0504 0.0521
Brugia malayi Matrixin family protein 0.0068 0.0395 0.181
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0021 0.0051 0.1692
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0227 0.8727
Echinococcus granulosus cpg binding protein 0.0061 0.0345 0.0351
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0028 0.0003
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0281 0.1288
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.004
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0021 0.0052 0.0053
Echinococcus granulosus microtubule associated protein 2 0.1352 0.9812 1
Leishmania major trypanothione reductase 0.0045 0.0227 0.1111
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0163 0.08
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0021 0.0052 0.0053
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0263 0.1287
Loa Loa (eye worm) hypothetical protein 0.0041 0.0194 0.0891
Schistosoma mansoni bromodomain containing protein 0.007 0.0406 0.0414
Trypanosoma cruzi metacaspase, putative 0.0044 0.0216 0.1059
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0021 0.0052 0.0026
Onchocerca volvulus Cell death protein 3 homolog 0.0085 0.0516 0.4946
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0009 0.0009
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.0954 0.4378
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0045 0.0228 0.8761
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0021 0.0051 0.0586
Loa Loa (eye worm) hypothetical protein 0.0047 0.0241 0.1104
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0021 0.0051 0.0438
Echinococcus multilocularis dual specificity mitogen activated protein 0.0074 0.0438 0.0446
Plasmodium falciparum metacaspase 1 0.0044 0.0216 0.828
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0312 0.0318
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0038 0.0039
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0098 0.1238
Brugia malayi PHD-finger family protein 0.0033 0.0134 0.0612
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0163 0.5835
Trypanosoma brucei metacaspase MCA2 0.0044 0.0216 0.1059
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0152 0.0303
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0193 0.0947
Echinococcus multilocularis caspase 2 0.0085 0.0516 0.0525
Echinococcus granulosus apoptotic protease activating factor 1 0.0041 0.0194 0.0198
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0336 0.0342
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0042 0.0042
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0038 0.0039
Trypanosoma brucei protein kinase, putative 0.0051 0.0268 0.1315
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0573 0.4095 1
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0045 0.0228 0.1119
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.004
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0044 0.0216 0.2869
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0048 0.0244 0.053
Schistosoma mansoni hypothetical protein 0.002 0.0038 0.0039
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0312 0.0322
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.0732 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0021 0.0052 0.0026
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0248 0.1712 0.1745
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.2041 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.015 0.0153
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0042 0.0042
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0322 0.0328
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.004
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0044 0.0216 0.022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.4095 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0088 0.0405
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0336 0.0342
Leishmania major metacaspase, putative 0.0044 0.0216 0.1059
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0336 0.4526
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0021 0.0052 0.0026

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 6.309573445 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 7.943282347 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 19.95262315 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (ADMET) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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